Готові списки джерел за темами / Deep Invasive Endometriosis (DIE)

Добірка наукової літератури з теми "Deep Invasive Endometriosis (DIE)"

Автор: Grafiati

Опубліковано: 1 червня 2024

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Deep Invasive Endometriosis (DIE)".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "Deep Invasive Endometriosis (DIE)":

Davydov, A. I., L. M. Mikhaleva, M. B. Khabarova, R. A. Chilova, and V. A. Lebedev. "Endometrioid cystadenoma – deep ovarian endometriosis." Voprosy ginekologii, akušerstva i perinatologii 21, no. 3 (2022): 130–37. http://dx.doi.org/10.20953/1726-1678-2022-3-130-137.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Among all endometriosis lesions of female reproductive organs, ovarian endometrioma is the most discussed nosology. Since 2014, ovarian endometrioid cysts have been classified as benign tumors (WHO Classification of Tumours of Female Reproductive Organs, 4th edition). In 2021, the 11th revision of the International Classification of Diseases (ICD-11) was amended, according to which the term “endometrioid ovarian cyst” (from 2018 to 2021 – heading GA18.3 Ovarian endometriotic cyst, section GA18 Acquired abnormalities of ovary) is no longer used, and the clinical and morphological signs of these cysts are presented in the heading GA10.B5 Deep ovarian endometriosis. In 2020, WHO updated the histological classification of female genital tumors (Female Genital Tumours WHO Classification of Tumours, 5th Edition), in which the section “endometrioid tumors” is presented only with endometrioid cystadenoma and endometrioid adenofibroma without mentioning the endometrioid cyst, but in accordance with the ICD-11, endometrioid cystadenoma is coded as “GA10.B5 Deep ovarian endometriosis”. Thus, on the one hand, ovarian endometrioma is a neoplastic process and requires appropriate approaches when choosing treatment tactics, on the other hand, cystectomy for endometrioma is accompanied by a pronounced loss of ovarian reserve. A possible consensus in this problem seems to be a minimally invasive method in the treatment of patients with ovarian endometriomas – ethanol sclerotherapy with cytological examination of the aspirate obtained from the neoplasm. The effectiveness of sclerotherapy largely depends on the choice of postoperative hormonal therapy. Today, dienogest is considered to be the most effective “anti-endometrioid” progestogen. However, there is an erroneous opinion that ethinylestradiol neutralizes the antiproliferative effect of dienogest and stimulates the growth of endometriosis. On the contrary, ethinylestradiol enhances the inhibitory effect of progestogen on the growth of ovarian endometrioma cells. Key words: endometrioid cystadenoma, ovarian endometrioma, deep ovarian endometriosis, sclerotherapy, dienogest

Knez, Jure, Andraž Dovnik, Maja Pakiž, Igor But, Milan Reljič, Vida Gavrić Lovrec, Maja Banović, and Iztok Takač. "Contemporary approach to diagnostics in women with suspected pelvic endometriosis." Acta Medico-Biotechnica 12, no. 2 (November 29, 2021): 10–20. http://dx.doi.org/10.18690/actabiomed.182.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Endometriosis is a common chronic female reproductive system disease, characterised by the presence of endometrial tissue outside the endometrium and myometrium. It can severely compromise quality of life and have an impact on fertility. Although advances in conservative medical treatment options have been made, surgery is often a necessary part of treatment for this insidious disease.Historically, it was believed that only ovarian endometriosis could be diagnosed non-invasively by an ultrasound examination, while endometriosis at other locations could not be observed. With advances in imaging techniques over the last decades, this has changed dramatically and today deep pelvic endometriosis can be diagnosed non-invasively with high sensitivity and specificity. The aim of this review is to evaluate the contribution of clinical examination, laparoscopy, and non-invasive imaging techniques, mainly transvaginal ultrasound and magnetic resonance imaging, to diagnose deep pelvic endometriosis.Evidence shows that transvaginal ultrasound with high-quality equipment in experienced hands offers high diagnostic accuracy for deep pelvic endometriosis diagnosis. Comprehensive ultrasound examination should be used as a first-line method of choice in diagnostics of women with suspected endometriosisand chronic pelvic pain.

Berlanda, Nicola, Laura Benaglia, Lara Bottelli, Chiara Torri, Andrea Busnelli, Edgardo Somigliana, and Paolo Vercellini. "The impact of IVF on deep invasive endometriosis." European Journal of Obstetrics & Gynecology and Reproductive Biology: X 4 (October 2019): 100073. http://dx.doi.org/10.1016/j.eurox.2019.100073.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Baușic, Alexandra, Ciprian Coroleucă, Cătălin Coroleucă, Diana Comandașu, Roxana Matasariu, Andrei Manu, Francesca Frîncu, Claudia Mehedințu, and Elvira Brătilă. "Transvaginal Ultrasound vs. Magnetic Resonance Imaging (MRI) Value in Endometriosis Diagnosis." Diagnostics 12, no. 7 (July 21, 2022): 1767. http://dx.doi.org/10.3390/diagnostics12071767.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

(1) Background: Endometriosis is a widespread gynecological condition that causes chronic pelvic discomfort, dysmenorrhea, infertility, and impaired quality of life in women of reproductive age. Clinical examination, transvaginal ultrasonography (TVS), and magnetic resonance imaging (MRI) are significant preoperative non-invasive diagnosis procedures for the accurate assessment of endometriosis. Although TVS is used as the primary line for diagnosis, MRI is commonly utilized to achieve a better anatomical overview of the entire pelvic organs. The aim of this systematic review article is to thoroughly summarize the research on various endometriosis diagnosis methods that are less invasive. (2) Methods: To find relevant studies, we examined electronic databases, such as MEDLINE/PubMed, Cochrane, and Google Scholar, choosing 70 papers as references. (3) Results: The findings indicate that various approaches can contribute to diagnosis in different ways, depending on the type of endometriosis. For patients suspected of having deep pelvic endometriosis, transvaginal sonography should be the first line of diagnosis. Endometriosis cysts are better diagnosed with TVS, whereas torus, uterosacral ligaments, intestine, and bladder endometriosis lesions are best diagnosed using MRI. When it comes to detecting intestine or rectal nodules, as well as rectovaginal septum nodules, MRI should be the imaging tool of choice. (4) Conclusions: When diagnosing DE (deep infiltrative endometriosis), the examiner’s experience is the most important criterion to consider. In the diagnosis of endometriosis, expert-guided TVS is more accurate than routine pelvic ultrasound, especially in the deep infiltrative form. For optimal treatment and surgical planning, accurate preoperative deep infiltrative endometriosis diagnosis is essential, especially because it requires a multidisciplinary approach.

Mabrouk, M., S. Mahgoub, A. Vashisht, and R. Seracchioli. "Innovative Cadaveric Technique: Utilising n-Butyl Cyanoacrylate (n-BCA) for Deep Endometriosis Excision Simulation in Minimal Invasive Surgery Training." Facts, Views and Vision in ObGyn 16, no. 1 (March 2024): 83–85. http://dx.doi.org/10.52054/fvvo.16.1.002.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Background: Our study aimed to create a novel technique using n-butyl cyanoacrylate (n-BCA) for minimal access simulation training on cadavers in deep endometriosis excision. Objectives: A step-by-step video demonstration of using n-BCA in cadavers to simulate deep endometriosis. This technique is integrated into training sessions using cadavers aimed at enhancing surgical proficiency for deep endometriosis procedures. Material and Methods: Video article describing using n-BCA in cadavers as a simulation model. Result: This technique has been used in a hands-on cadaveric training course, and positive feedback supports the recommendation to incorporate this technique. Conclusion: Utilizing a human cadaver model proves beneficial for enhancing understanding of deep pelvic innervation. Implementing n-BCA in these cadaver dissections demonstrates both reproducibility and safety. This approach significantly contributes to refining surgical expertise in the excision of deep infiltrating endometriosis.

Sparic, Radmila, Gernot Hudelist, and Joerg Keckstein. "Diagnosis and treatment of deep infiltrating endometriosis with bowel involvement: A case report." Srpski arhiv za celokupno lekarstvo 139, no. 7-8 (2011): 531–35. http://dx.doi.org/10.2298/sarh1108531s.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Introduction. Deep infiltrating endometriosis is a form of endometriosis penetrating deeply under the peritoneal surface causing pain and infertility. Assessment of the pelvis by laparoscopy and histological confirmation of the disease is considered the golden standard of diagnosis. Case Outline. We are presenting a patient diagnosed with deep infiltrating endometriosis by transvaginal ultrasound and treated with minimally invasive radical surgery including segmental resection of the bowel. Conclusion. Transvaginal sonography has an important role in detecting deep endometriosis of the pelvis. Fertility sparing surgery is the treatment of choice in symptomatic women wishing to retain fertility, since drugs used for endometriosis interfere with ovulation. The success of the surgery depends on the accuracy of the preoperative diagnosis. A multidisciplinary approach in managing deep endometriosis is mandatory in order to offer patients the best possible treatment using the combined skills of the colorectal and gynaecologic surgical teams. The presented case exhibits the feasibility of laparoscopic approach to severe pelvic endometriosis with bowel involvement.

Arkfeld, Christopher, Julia Gelissen, Animesh Upadhyay, and Gary Altwerger. "Deep infiltrating endometriosis with mucinous metaplasia of mullerian origin." Journal of Endometriosis and Pelvic Pain Disorders 15, no. 2 (June 2023): 91–94. http://dx.doi.org/10.1177/22840265231178332.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Background: Endometriosis is a common gynecological condition that often presents with pelvic pain and infertility, but in rare cases may masquerade as a gastrointestinal or gynecologic malignancy. Case: A 49-year-old G0 presented with abdominal pain, fevers, elevated tumor markers, and a large adnexal mass concerning for malignancy. Intra-operatively, mucinous lesions diffusely involved abdominopelvic structures. Intra-operative frozen section (IOFS) revealed invasive cancer and full cytoreductive surgery was completed. Final pathology was downgraded to atypical cystic endometriosis with mucinous metaplasia. Conclusion: Endometriosis, a nonmalignant condition, can present as pelvic masses associated with elevated tumor markers. The case presented here depicts a confounding preoperative and intraoperative picture where endometriosis was falsely identified as malignancy. Endometriosis should always remain a part of the differential diagnosis in a premenopausal patient with presumed gastrointestinal or gynecologic malignancies.

Dewanto, Agung, Muhammad Dimas Reza Rahmana, Regina Arumsari, Nurida Khasanah, Wicesa Nugraha, Vanessa Trizia, and Khoiruddin Anshori. "#125 : The Role of BDNF Receptors in the Incidence of Endometrioma Tissue Invasion Onto the Chorioallantoic Membrane." Fertility & Reproduction 05, no. 04 (December 2023): 629–30. http://dx.doi.org/10.1142/s2661318223743618.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Background and Aims: Previous studies have explored the role of neurotrophins and their receptors, especially in forming deep endometriosis, endometriosis tissue invasion, and its effects on tissue proliferation. However, these studies do not include research on the pathogenesis of endometriomas. We tried to model the invasion of endometrioma tissue to find out more about its pathogenesis by using the chorioallantoic membrane (CAM) as the host. Immunohistochemistry (IHC) to detect neurotrophin BDNF and its receptors, namely TrkB and P75, are employed and linked between their expression and the process of invasion and proliferation. Method: The endometriotic tissue samples were collected from women (n=27) who underwent hysteroscopy/laparoscopy at Dr. Sardjito Central Hospital. Peritoneal endometriosis (PE) lession, endometrioma (CC), and eutopic endometrium (EN) was analyzed with 15 tissue samples in each group. Samples were placed in a tube containing transport medium and transplanted into CAM of fertile chicken eggs for five days. Transplanted tissue was harvested, and histological preparations were made using the paraffin method. IHC staining was performed on p75, Ki67, TrkB, and BDNF staining. Invasion analysis and IHC evaluation were performed with a semi-quantitative method. Data were analyzed using IBMⓇ SPSS Statistics version 25.0. Statistical significance was accepted at P < 0.05. Results: Normal Endometrium expressed the highest expression of BDNF than peritoneal endometriosis and endometrioma (0.36± 0.38, 0.16± 0.13, 0.07± 0.07, P=0.007). The P75 expression correlated positively with Ki67 expression in PE and CC samples (P=0.012; P=0.008). Conclusion: The p75 receptor may have a role in endometriosis tissue proliferation, but this receptor does not directly influence tissue invasion into CAM. While proliferation in endometriomas positively correlates with invasion into CAM, it is not correlated with peritoneal endometriosis.

Ćorić, Mario, Marija Gregov, Marko Jakov Šarić, Mislav Mikuš, Franjo Grgić, Nikola Knežević, Petar Matošević, and Ivo Brozović. "One-stage, radical laparoscopic endometriosis excision involving three different organ systems: A case report from tertiary referral center." Journal of Endometriosis and Pelvic Pain Disorders 12, no. 3-4 (June 15, 2020): 115–19. http://dx.doi.org/10.1177/2284026520928246.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Introduction: We present a case of an extensive endometriosis involving left paracolpium and left parametrium, rectovaginal septum, urinary bladder, left interiliac region between artery and vein, left ureter and rectum, presenting as dysmenorrhoea, alternating bouts of diarrhea and constipation and hydronephrosis. Methods: Laparoscopic surgery made by a multidisciplinary team consist of gynecologic, abdominal surgeon and urologist. Results: Successfully managed deep infiltrated endometriosis. Conclusion: The aim of this report is to demonstrate benefit of one-stage, minimally invasive radical surgical procedure performed in a tertiary referral center. To the best of our knowledge, this report presents an extremely complex case because we successfully managed deep infiltrating endometriosis in three different organ systems at the same time, using minimally invasive nerve-sparing technique. A case with the same constellation has not been published yet since reported cases of extrapelvic endometriosis chiefly address one organ system involvement.

Daniilidis, Angelos, Georgios Grigoriadis, Dimitra Dalakoura, Maurizio N. D’Alterio, Stefano Angioni, and Horace Roman. "Transvaginal Ultrasound in the Diagnosis and Assessment of Endometriosis—An Overview: How, Why, and When." Diagnostics 12, no. 12 (November 23, 2022): 2912. http://dx.doi.org/10.3390/diagnostics12122912.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Endometriosis is a common gynaecological disease, causing symptoms such as pelvic pain and infertility. Accurate diagnosis and assessment are often challenging. Transvaginal ultrasound (TVS), along with magnetic resonance imaging (MRI), are the most common imaging modalities. In this narrative review, we present the evidence behind the role of TVS in the diagnosis and assessment of endometriosis. We recognize three forms of endometriosis: Ovarian endometriomas (OMAs) can be adequately assessed by transvaginal ultrasound. Superficial peritoneal endometriosis (SUP) is challenging to diagnose by either imaging modality. TVS, in the hands of appropriately trained clinicians, appears to be non-inferior to MRI in the diagnosis and assessment of deep infiltrating endometriosis (DIE). The IDEA consensus standardized the terminology and offered a structured approach in the assessment of endometriosis by ultrasound. TVS can be used in the non-invasive staging of endometriosis using the available classification systems (rASRM, #ENZIAN). Given its satisfactory overall diagnostic accuracy, wide availability, and low cost, it should be considered as the first-line imaging modality in the diagnosis and assessment of endometriosis. Modifications to the original ultrasound technique can be employed on a case-by-case basis. Improved training and future advances in ultrasound technology are likely to further increase its diagnostic performance.

Більше джерел

Дисертації з теми "Deep Invasive Endometriosis (DIE)":

Fastrez, Maxime. "Minimal-invasive management of deep infiltrating endometriosis: diagnosis and treatment." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271669.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

L’endométriose est une pathologie chronique qui provoque des douleurs pelviennes et une infertilité. On décrit trois phénotypes d’endométriose :l’endométriose péritonéale superficielle, les kystes ovariens d’endométriose (endométriomes) et l’endométriose profonde.L’examen standard pour le diagnostic de l’endométriose est, encore aujourd’hui, la laparoscopie. Nous avons étudié, de façon prospective, l’utilité d’un examen non invasif, la tomographie par émission de positrons (PET), chez les patientes avec suspicion d’endométriose. Nous n’avons pas mis en évidence d’hyperactivité métabolique sur les images de PET pré opératoires, après injection de déoxyglucose marqué au 18F (18FDG), des lésions d’endométriose ayant été confirmées par laparoscopie. Nous avons réalisé, dans un second temps, la même étude après injection d’un analogue de la somatostatine, le DOTATATE, marqué au 68Ga, qui montre une avidité pour les récepteurs à la somatostatine (SSTR) de type 2. Dans cette dernière étude, seules les lésions d’endométriose profonde se sont révélées hyperactives sur les images pré opératoires de PET. Nous avons ensuite réalisé une étude immunohistochimique rétrospective sur différents échantillons d’endométriose superficielle, d’endométriomes et d’endométriose profonde. Nos résultats ont confirmé l’expression de SSTR de type 1 et 5 par les cellules épithéliales des trois phénotypes d’endométriose. Par contre, seules les lésions d’endométriose profonde exprimaient les SSTR de type 2.Le traitement chirurgical des endométriomes et de l’endométriose superficielle est bien codifié. Par contre, la chirurgie de l’endométriose profonde reste au cœur des débats dans la littérature. Nous avons évalué notre aptitude à appliquer les techniques de chirurgie mini-invasive aux procédures complexes telles que la résection des nodules d’endométriose profonde du septum recto-vaginal (NEPSRV). Nous avons évalué la faisabilité de la laparoscopie avec assistance robotique pour une autre procédure complexe :la dissection des ganglions para-aortiques dans le cadre des cancers du col utérin localement avancés. Nous l’avons jugée faisable et sûre pour les patientes. En l’absence de bénéfice démontré de la laparoscopie avec assistance robotique sur la laparoscopie conventionnelle pour le traitement des NEPSRV, nous avons décidé d’évaluer une nouvelle stratégie opératoire mini-invasive de résection des NEPSRV. Nous avons réalisé une analyse des 10 premières patientes opérées selon cette stratégie et avons montré une amélioration significative des symptômes et de la qualité de vie des patientes. Nous avons également étudié la morbidité post opératoire. Nous avons finalement étudié l’apport de la laparoscopie guidée par la fluorescence au traitement des NEPSRV et observé des résultats prometteurs.A l’avenir, les lésions symptomatiques d’endométriose profonde exprimant les SSTR2 pourraient être sélectionnées à l’aide d’un PET au 68Ga-DOTATATE afin d’être traitées, dans le cadre d’essais cliniques, par des analogues de la somatostatine. Ces thérapies ciblées permettaient, dans ces cas, d’éviter la chirurgie. Notre stratégie opératoire mini-invasive pourraient dès lors être appliquée aux lésions n’exprimant pas les SSTR2.
Doctorat en Sciences médicales (Médecine)
info:eu-repo/semantics/nonPublished

Borrelli, Giuliano [Verfasser]. "Investigation of invasion factors in deep-infiltrating endometriosis / Giuliano Borrelli." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1079524592/34.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Philip, Charles-André. "Description, évaluation et perfectionnement d’une nouvelle technique de prise en charge de l'endométriose profonde postérieure recto-sigmoïdienne par ultrasons focalisés de haute intensité (HIFU) échoguidés par voie transrectale." Electronic Thesis or Diss., Lyon, 2020. http://www.theses.fr/2020LYSE1065.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

OBJECTIFS : Dans cette thèse nous avons décrit une nouvelle technique de prise en charge de l'endométriose profonde postérieure recto-sigmoïdienne par ultrasons focalisés de haute intensité échoguidés par voie transrectale (TR-USgHIFU), avant de rechercher les facteurs limitants de cette technique ainsi que les moyens d’améliorer sa faisabilité et son efficacité. METHODES : Nous avons tout d’abord conduit une étude clinique de phase I pour tester la faisabilité du traitement par TR-USgHIFU à l’aide de la sonde FocalOne®. Nous avons ensuite réalisé une étude sur pièces anatomiques visant à rechercher les facteurs limitants l’utilisation de la sonde FocaleOne® et à tester un autre prototype de sonde HIFU comme alternative à cette dernière. Nous avons également réalisé une étude clinique observationnelle pour mesurer l’atténuation acoustique des lésions d’endométriose recto-sigmoïdienne et de l’intestin normal. Nous avons enfin mis au point un modèle murin d’endométriose sous-cutané pour évaluer les effets anatomo-pathologiques des HIFU sur l’endométriose. RESULTATS : Nous avons inclus 23 patientes dans l’étude clinique de phase I entre juin 2015 et octobre 2019 dont 20 ont pu être traitées (faisabilité de 87%). Aucun effet indésirable grave n’a été rapporté. Nous n’avons pas observé pas de modification significative du volume des lésions à 6 mois, mais nous rapportons une amélioration significative des symptômes douloureux digestifs et gynécologiques ainsi qu’une amélioration de la qualité de vie des patientes. Les analyses sur pièces anatomiques et sur IRM démontrent le rôle du sacrum et de la charnière recto-sigmoïdienne dans les limitations mécaniques de la sonde FocalOne®. L’utilisation d’une sonde moins encombrante avec une focale plus courte semble être bénéfique pour augmenter la faisabilité du traitement. Notre étude sur 13 patientes traitées chirurgicalement d’un nodule du rectum ou du sigmoïde, a montré que l’atténuation à 3 MHz de l’endométriose digestive est de 50,2 Np/m. Cette valeur est significativement plus élevée que celle de l’intestin sain (32,8 ; p<0,001). Nous avons enfin montré que le modèle murin hétérologue sous-cutané « BALB/c-nude#Ishikawa » est fiable et performant pour l’étude des effets des HIFU sur l’endométriose profonde digestive, en raison notamment d’une atténuation acoustique remarquablement proche de celle de l’endométriose recto-sigmoïdienne. Grâce à ce modèle nous avons démontré que le traitement HIFU provoquait une nécrose de type « ischémique » au niveau de la cible. CONCLUSION : Le traitement par TR-USgHIFU dans l’endométriose recto-sigmoïdienne est faisable et sûr. Son efficacité morphologique reste à démontrer mais son efficacité clinique significative est prometteuse. Il pourrait s’agir d’une alternative minimalement invasive de choix pour remplacer le traitement chirurgical dans cette indication, en particulier pour les lésions les plus basses situées
OBJECTIVES: In this thesis we describe a new technique for the management of rectosigmoid endometriosis by transrectal ultrasound-guided high intensity focused ultrasound ultrasound (TR-USgHIFU). We also review several limiting factors of this technique before assessing several modifications to improve the feasibility and the efficacy of the procedure. METHODS: We first conducted a phase I clinical trial to test the feasibility of TR-USgHIFU treatment using the FocalOne® device. We then carried out a study on anatomical specimens to assess the limiting factors of the FocaleOne® probe and to test another HIFU probe, which has smaller transducer and which is mounted on a flexible endoscope. We also performed an observational clinical study to measure the acoustic attenuation of rectosigmoid endometriosis lesions and that of normal bowel. Finally, we have developed a murine model of subcutaneous endometriosis to assess the pathophysiological effects of HIFU on endometriosis. RESULTS: We included 23 patients in the phase I clinical trial between June 2015 and October 2019. Treatment was carried out in 20 of these patients (87% feasibility). No serious adverse events have been reported. We did not find a significant morphological effect at 6 months, but we report a significant improvement on digestive and gynecological symptoms as well as on patients’ quality of life. Studies on anatomical specimens and on MRI pictures demonstrated the role of the sacrum and the recto-sigmoid hinge in the mechanical limitations of the FocalOne® probe. The use of a smaller probe with a shorter focal could be interesting in order to increase the feasibility of the treatment. Our study on 13 patients treated surgically for rectum or sigmoid endometriosis nodule, showed that attenuation of digestive endometriosis at 3 MHz is 50.2 Np / m. This value was significantly higher than attenuation of the normal bowel (32.8; p <0.001). We finally showed that the heterologous subcutaneous murine model "BALB / c-nude # Ishikawa" was reliable and efficient to study the effects of HIFU on digestive endometriosis, as the acoustic attenuation of its nodules are remarkably close to that of endometriosis lesions. Thanks to this model, we reported that HIFU lesions are associated with a higher rate of ischemic and coagulation necrosis. CONCLUSIONS: Treatment with TR-USgHIFU in rectosigmoid endometriosis is feasible and safe. Its morphological efficacy remains to be demonstrated, but its significant clinical efficacy is promising. It could become be a minimally invasive alternative to replace surgical treatment in this indication, especially for rectal lesions

Anaf, Vincent. "Contribution to the physiopathology, symptomatology and treatment of deep infiltrating endometriosis." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211116.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

L’endométriose est définie comme la présence de tissu endométrial et de stroma en dehors de la cavité utérine. Ses localisations les plus fréquentes sont le péritoine pelvien et les ovaires. L’endométriose infiltrante est classiquement décrite comme la présence de tissu endométriotique plus de cinq millimètres sous le péritoine pelvien ou la séreuse d’un organe. Histologiquement il s’agit d’une lésion endométriotique mais qui contrairement aux lésions ovariennes ou péritonéales contient significativement plus de muscle lisse et de fibrose et est davantage associée à la douleur. Les lésions infiltrantes peuvent être responsables de dysménorrhée, dyspareunie profonde et douleurs pelviennes chroniques sévères ayant un charactère hyperalgique tel qu’on peut le retrouver dans les douleurs neuropathiques. Ces douleurs nécessitent souvent la prise de quantités importantes d’antalgiques et ont des répercussions importantes sur la vie professionnelle, quotidienne et sexuelle des femmes atteintes. L’endométriose infiltrante présente un rapport histologique étroit avec les structures nerveuses du rétropéritoine ou les nerfs des organes atteints. Dans sa localisation rectovaginale il existe une relation histologique étroite entre les lésions d’endométriose et les nerfs ainsi qu’une correlation entre l’intensité de la douleur et le nombre de structures nerveuses envahies par l’endometriose ou engaînées dans la fibrose. Ces lésions infiltrantes expriment le «nerve growth factor» (NGF), une neurotrophine qui joue un rôle clé dans la genèse de l’hyperalgie et de la douleur. Les structures nerveuses du rétropéritoine pelvien expriment quant à elles le récepteur spécifique pour la neurotrophine NGF. Le système «NGF-récepteur spécifique» peut être responsable d’un chimiotactisme tissulaire entre les tissus sécrétant du NGF et les nerfs qui expriment le récepteur pour le NGF. Le système «NGF- récepteur spécifique» au sein de la relation endométriose-nerfs pourrait rendre compte du caractère hyperalgique des lésions endométriotiques infiltrantes ainsi, qu’expliquer pourquoi les lésions nodulaires n’apparaissent que dans les sites anatomiques richement innervés (ligaments utérosacrés, lame rectovaginale, paroi du rectum ou du côlon…) et pas ailleurs. Le traitement de première intention est chirurgical. Il convient d’être suffisamment agressif sur les lésions tout en engendrant le moins de séquelles postopératoires possibles sachant que nombre de ces femmes sont stériles. En cas d’atteinte digestive basse, les modalités de l’intervention sont dictées par l’extension et le degré d’infiltration de la paroi digestive. Dans le but de réaliser dans la majorité des cas une chirurgie minimalement invasive (laparoscopique) avec des cicatrices de petites tailles, nous avons développé une stratégie de traitement basée sur le degré d’infiltration de la paroi digestive. Dans ce cadre nous avons développé une technique laparo-assistée de résection colique segmentaire et de résection antérieure du rectum.
Doctorat en sciences médicales
info:eu-repo/semantics/nonPublished

Ruge, Diane. "Deep brain stimulation-mediated and non-invasive modulation of neuronal circuits." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1471231/.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Deep brain stimulation (DBS) has emerged as an effective treatment for therapy resistant psychiatric and neurological disorders, such as dystonia. For subforms, so called task specific dystonia, interventions utilizing the effects of shift of locus of attention have been used. The mechanism of the latter nor of DBS are well understood. My work in the context of this thesis involved various methods including the use of combined DBS and functional Magnetic Resonance Imaging and cohorts with neuropsychiatric patients. However, this write-up summarizes four conceptually linked projects that explore the mechanistic relevance of cortical circuits for the aforementioned interventions. First, using electrophysiological methods, I explored the mechanisms of DBS during the early treatment phase in dystonia. Typically the time course is gradual, despite the fact that DBS instantly interacts with abnormal oscillations. The results led to the hypothesis that pre-existing high levels of plasticity had formed motor memories of dystonic movement patterns, and that even though synaptic plasticity was reduced quickly by DBS, it took time for the motor system to acquire more normal movement. Second, in long term DBS treated patients intriguingly it has been found that, in some cases (but not all), DBS can be stopped for many days without any return of symptoms. My research suggested that DBS leads to persisting functional changes in the brain and that different electrophysiological signatures are associated with the retention or the loss of achieved clinical benefit when DBS is stopped and that via the programming of DBS these can be shaped. In a subsequent study results suggested that the achieved clinical benefit might be at risk when DBS is interrupted for too long. Finally, non-invasive interventions using attention modulation unexpectedly shift cortical circuit excitation towards increased excitability irrespective of the locus of attention. This finding has several clinical implications.

Ali, Laila. "Endometriosis and the lympathic system: lymph nodes draining the uterus and deep infiltrating endometriotic lesions of the bowel." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/12638.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Endometriosis is associated with locally dysregulated immune responses and increased lymphangiogenesis. This study aimed to examine endometrial-like cells and immune cell populations in uterine-draining iliac lymph nodes throughout the menstrual cycle and lymph nodes associated with deep infiltrating endometriotic lesions of the bowel. Paraffin-embedded uterine-draining iliac lymph nodes (endometriosis = 6, control = 9) and deep infiltrating bowel endometriotic lesion-associated nodes (n = 12) were immunohistochemically stained for endometrial-like cells and a range of immune cells. In uterine-draining iliac nodes, DC-Sign+ cell numbers and CD4 antigen expression peaked during menstruation, and CD20 antigen expression significantly decreased between the proliferative and secretory phases. In deep infiltrating bowel endometriosis associated nodes, CD10+ endometrial-like cells were decreased compared to iliac nodes; CD4+ numbers, and CD4 and FoxP3 antigen expression were increased but DC-Lamp+, CD20+ and CD57+ numbers and DC-Lamp, CD79 and CD57 antigen expression were decreased. The presence of endometrial-like cells and dysregulated immune cell environment in pelvic lymph nodes indicate an important role for the lymphatic system in endometriosis. This study provides new evidence for lymphatic and immune system involvement in the development and progression of endometriosis, which may open up new venues for exploring lymphatic-based therapeutic approaches.

Ploteau, Stéphane. "Etude du lien entre l’exposition aux polluants organiques persistants et l’endométriose." Thesis, Nantes, Ecole nationale vétérinaire, 2016. http://www.theses.fr/2016ONIR087F/document.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

L’endométriose est une maladie gynécologique pour laquelle l’exposition à certains contaminants chimiques environnementaux est évoquée parmi les facteurs de risque associés. Les conclusions des études épidémiologiques existantes restent toutefois non convergentes. Leur hétérogénéité en termes de lésions décrites, de méthodologie et d’effectifs contribuent à ce constat, de même que l’étendue limitée des marqueurs d’exposition considérés dans ces études. Nous avons réalisé une étude cas-témoins appariés à partir d’une bio-collection de 113 patientes réunissant68 cas de patientes opérées d’endométriose profonde et 45 patientes témoins. Un ensemble unique de 78 polluants organiques persistants a été recherché, incluant dioxines, polychlorobiphényles, retardateurs de flamme polybromés, et pesticides organochlorés. Les niveaux d’exposition interne des sujets ont été mesurés à la fois dans les tissus adipeux pariétal et épiploïque ainsi que dans le sérum. La distribution de ces différents polluants au sein de ces trois compartiments a tout d’abord été caractérisée. Celle-ci a permis la prise en compte encore très rare de l’équilibre entre compartiments de stockage et compartiment circulant, ce rapport de concentration apparaissant comme un potentiel indicateur additionnel permettant d’affiner d’éventuels liens de causalité entre exposition chronique à des dangers chimiques et pathologie chez l’homme. Certains des contaminants ciblés sont ensuite apparus significativement associés à l’endométriose profonde, la stratification plus fine de notre population de cas indiquant un lien d’autant plus significatif en présence d’endométriome. Les mécanismes sous-jacents de cette association restent toutefois à élucider
Endometriosis is a gynecological disease for whichexposure to some environmental chemicals is evocatedamong the associated risk factors. Epidemiological studies are however globally non convergent and finally fairly conclusive. Their heterogeneity in terms of lesion localization and sub-phenotype, methodology, size and nature of the populations studied, as well as the limited number of monitored markers of exposure contribute to this situation. We realized a matched case-control study based on a biocollection of 113 patients including 68 patients suffering of deep endometriosis and 45 controls. We characterized the internal exposure levels of an extended range of around 78 persistent organic pollutants (including dioxins, polychlorobiphenyls, brominated flame retardants and organochlorine pesticides). Internal level exposures were measured in three biological compartments (omental fat, subcutaneous fat and serum). First, the distribution of these chemicals was characterized within these compartments. These extended exposure data from deep infiltrating endometriosis patients are the first ones available for France and give a new insight about the equilibrium of chemicals between storage and circulating compartments that should be further considered as a potential indicator permitting to establish a possible association between a chronic exposure to chemical hazards and human pathology. Afterwards, some of the targeted chemicals appeared significantly associated with deep endometriosis. A sub-stratification of our case population indicated a more significant relationship with the presence of endometrioma. Underlying mechanisms remain to be determined

Lamp, Julika. "Etablierung nicht invasiver Testsysteme zur Darstellung von Beeinträchtigungen und Schmerzen in einem Primatenmodell für Endometriose." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-61348.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Endometriose (EM) ist eine häufige gynäkologische Erkrankung, die bei betroffenen Frauen unter anderem mit chronischen Unterleibsschmerzen und Unfruchtbarkeit einhergeht (VALLE 2002). Bisher war es bei den zur Forschung verwendeten Modelltieren für EM (z.B. Rhesusaffe, ZONDERVAN et al. 2004; Weißbüschelaffe, EINSPANIER et al. 2006) nicht möglich festzustellen, ob bei ihnen schmerzhafte Beeinträchtigungen durch die Erkrankung bestehen. Um die Auswirkungen neuer Therapeutika auf das Wohlbefinden der Patientinnen bewerten zu können, werden Methoden benötigt, mit denen EM bedingte Beeinträchtigungen der Modelltiere dargestellt werden können. Daher war es das Ziel dieser Studie, bei einem Primatenmodell für EM, dem Weißbüschelaffen, neue nicht invasive Testsysteme zu etablieren, die zur Darstellung von EM bedingten Schmerzen und Beeinträchtigungen geeignet sind. Unter der Annahme, dass schmerzhafte Erkrankungen das Verhalten (WALLACE et al. 1990), die Beweglichkeit (FLECKNELL 1986) sowie die kognitiven Fähigkeiten (SMITH et al. 2006) der betroffenen Tiere beeinträchtigen können, wurden drei nicht invasive Testsysteme auf ihre Eignung untersucht, Schmerzen bei an EM erkrankten Weißbüschelaffen im Vergleich zu Kontrolltieren darzustellen. Zur Untersuchung des Verhaltens wurde die Videoüberwachung, für die motorischen Fähigkeiten der Futterbaum (modifiziert nach ROBERTS et al. 1993) und für die kognitiven Fähigkeiten der Wisconsin General Test Apparatus (WGTA, HARLOW 1949) sowie der Futterbaum verwendet. Im ersten Abschnitt dieser Studie wurde das Normalverhalten von neun Weißbüschelaffenpaaren per Videokamera über den gesamten Tagesverlauf von zwölf Stunden aufgezeichnet und unter anderem in Bezug auf Aktivität, soziale und eigene Körperpflege sowie Futter- und Wasseraufnahme analysiert. Der Verlauf der Tagesaktivität zeigte drei Maxima zwischen 7:00 und 8:00 Uhr, 11:00 und 12:00 Uhr sowie 14:00 und 15:00 Uhr, dabei war die ansteigende Aktivität als Futtersuchverhalten vor den Mahlzeiten zu werten. Das im ersten Abschnitt der Studie dargestellte Aktivitätsmuster wurde im zweiten Abschnitt verwendet, um die Versuche mit WGTA und Futterbaum besser in den Tagesverlauf der Tiere einzuordnen und darüber ihre Kooperativität zu steigern. Die Tiere führten die Tests immer zur gleichen Tageszeit durch, deshalb wurde somit eine optimale Vergleichbarkeit und Homogenität der Ergebnisse gewährleistet. Bei der Auswertung der Videodokumentation im zweiten Abschnitt dieser Studie zeigte sich, dass erkrankte Weibchen ihren Partner im Gegensatz zu den Kontrolltieren gar nicht pflegen (p=0,029) und die Aktivität der erkrankten Weibchen zwar deutlich, aber nicht signifikant (p=0,057) verringert war. Diese verringerte Aktivität ist möglicherweise ein Hinweis auf Schmerzen der an EM erkrankten Weibchen, während die nicht vorhandene soziale Körperpflege den partnerschaftlichen Problemen betroffener Frauen entsprechen könnte. In den ersten beiden kognitiven Tests mit dem WGTA führten die erkrankten Weibchen signifikant weniger Versuche pro Tag durch als die Kontrolltiere (p=0,006/ p=0,008). Darüber hinaus benötigten die erkrankten Tiere signifikant mehr Versuche, um den ersten Test zu verstehen (p=0,008). Diese Unterschiede zu den Kontrolltieren ließen sich in den folgenden drei Versuchsabschnitten nicht mehr nachweisen. Daraus lässt sich ableiten, dass die Weibchen mit EM sich schlecht auf neue Anforderungen einstellen und sich weniger lange auf eine gestellte Aufgabe konzentrieren können. Nach der International Primatological Society (MC CANN et al. 2007) kann eine verminderte Fähigkeit, sich auf neue Situationen einzustellen, als Anzeichen für Beeinträchtigungen gewertet werden. Bei der Auswertung der Futterbaum Testreihen, in denen sowohl kognitive als auch motorische Fähigkeiten der Tiere mit einer Art „Kletterbaum“ überprüft wurden, ergaben sich demgegenüber keine signifikanten Unterschiede zwischen der EM-Gruppe und den Kontrolltieren. Zusammenfassend eignen sich die Videodokumentation und der WGTA zur Darstellung von Beeinträchtigungen bei an EM erkrankten Weißbüschelaffen. Die beiden Testsysteme können in folgenden pharmakologischen Studien verwendet werden, um erstmals die Auswirkungen neuer Therapeutika auf das Wohlbefinden der Modelltiere zu bewerten. Zusätzlich ermöglichen die Ergebnisse dieser Studie ein Refinement (RUSSELL und BURCH 1959), da die bisher verwendeten invasiven Methoden (Laparoskopie, Laparotomie) zur Bewertung des Verhaltens der EM Läsionen unter einer Therapie ergänzt und sogar ersetzt werden könnten
Endometriosis (EM) is a common gynecological disease, which is known to cause chronic pelvic pain and infertility in women (VALLE 2002). Up to now, it was not possible to assess, whether the animal models for research (e.g. rhesus macaque, ZONDERVAN et al. 2004; common marmoset, EINSPANIER et al. 2006) suffer from pain or impairments due to the disease. Therefore, new test systems are needed to obtain pain and discomfort in animal models for EM to enable the validation of new therapeutic agents with a view to the patients well being. It was the aim of this study, to establish new non invasive test systems to investigate signs of discomfort in an animal model for EM, the marmoset monkey. Assuming that painful diseases can influence the behaviour (WALLACE et al. 1990), the mobility (FLECKNELL 1986) and the cognitive abilities (SMITH et al. 2006) of animals, three non invasive test systems were reviewed for their ability to detect EM associated pain in common marmosets. They were based on behaviour (videotaping), mobility and exploratory behaviour (food tree, modified after ROBERTS et al. 1993) and cognitive abilities (Wisconsin General Test Apparatus (HARLOW 1949) and food tree). In the first part of this study, the daily activity patterns, allo- and autogrooming as well as water and food intake of nine common marmoset couples were monitored over a 12-hour light phase by video recording. The animals showed a trimodal course of activity per day with maxima from 7:00-8:00h, 11:00-12:00h and 15:00-16:00h. These activity maxima represented foraging behaviour, as they were followed by frequent food intake phases. The knowledge of the daily activity patterns allowed to optimize the experimental conditions for the tasks with the food tree and the Wisconsin General Test Apparatus (WGTA; HARLOW 1949) in the second part of this study. As every animal solved the tasks at the same time of day, the comparability and homogeneity of the results were optimized. By analysing the video documentation in the second part of this study, the females with EM, in contrast to the control females, did not show any social grooming behaviour (p=0.029). Furthermore, their activity level was almost significantly decreased (p=0.057). This reduced activity could indicate towards pain in the diseased females, while the lack of social grooming is similar to partnership problems in diseased women. The WGTA tasks revealed, that the females with EM performed significantly less trials per day in the first two settings (p=0.006/ p=0.008) and needed more trials to solve the first setting than the control animals (p=0.008). Those differences between diseased females and control animals were not detectable in the following three settings of the WGTA tasks. These results demonstrate, that EM affected marmosets have difficulties to concentrate on cognitive tasks and to cope with new situations. According to the International Primatological Society (MC CANN et al. 2007), these difficulties to cope with new situations can be interpreted as signs of distress. The food tree, a kind of jungle gym, was used to assess the animals` cognitive abilities as well as their mobility, but there were no significant differences between the EM diseased females and the control animals. In conclusion, the videotaping and the WGTA are suitable methods to demonstrate signs for impairments due to EM in marmoset monkeys. In following pharmacological studies, both test systems will allow to evaluate the benefit of new therapeutic agents on the animal model`s well being. In addition, the results of this study can help to refine procedures by replacing invasive methods like laparotomy according to the Refinement of RUSSELL and BURCH (1959)

Daum, Douglas R. 1968. "A large scale phased array ultrasound system for non-invasive surgery of deep seated tissue." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/85261.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.
Includes bibliographical references (leaves 229-239).
by Douglas R. Daum.
Ph.D.

Pitman, Jeremy David. "Non-invasive detection of the electromyographic activity of the deep extrinsic thumb muscles using surface electrodes." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16783.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Includes bibliographical references
Motivation: Conventional surface electromyography (EMG) methods cannot be used to detect deep muscle activation. A new non-invasive superficial and deep muscle EMG (sdEMG) technique has recently been used to derive the EMG activity of Brachialis and Tibialis Posterior muscles in the upper and lower limb respectively. The aim of the present study was to apply a modified version of sdEMG to the forearm to detect EMG activity of the deep extrinsic thumb muscles Flexor Pollicis Longus (FPL), Extensor Pollicis Longus (EPL), Extensor Pollicis Brevis (EPB) and Abductor Pollicis Longus (APL) using surface electrodes. Methods: High density monopolar EMG was detected from 2 concentric rings, each consisting of 20 custom designed and manufactured silver electrodes, placed at the distal and proximal thirds of the right forearm of 15 healthy male participants. The EMG signals were recorded by a custom synthesised from open source components, EMG amplifier system interfacing with a custom designed LabVIEW® program. The participants performed 10 repetitions of isometric thumb flexion (TFl), thumb extension (TEx), thumb abduction (TAb), thumb adduction (TAd), index finger flexion (IFFl) and index finger extension (IFEx). Each isometric contraction was performed in a randomized order at a standardized effort level of 30% of the participant's maximum voluntary contraction (verified by a custom designed and built thumb dynamometer). The Independent Component Analysis (ICA) algorithm, fastICA, was used to un-mix the 40 monopolar EMG waveforms (containing EMG activity attributable to both superficial and deep muscles) into 40 constitutive components, known as the Independent Components (ICs). The activation envelope of the ICs was found using a 250ms RMS smoothing filter and normalized between 0 and 1. A contraction sequence specific predicted EMG waveform based on intramuscular measurements (from existing studies in the literature) was created for each deep muscle and correlated with the processed ICs using Pearson's Correlation Coefficient (r). The ICs were ranked according to the corresponding r value and the highest r ranked IC for each muscle was considered to represent the recovered EMG activity from that particular muscle. Finally, a per sample basis accuracy, sensitivity and specificity analysis was conducted between each deep muscle's predicted EMG and highest r ranked IC at different activation thresholds. A linear mixed-effects statistical model was used to find the overall accuracy, sensitivity and specificity values over all the thresholds for each deep muscle. Results: Overall correlations of 0.81 for FPL (D), 0.88 for EPL (D), 0.92 for EPB (D) and 0.83 for APL (D) (p<0.001 for all muscles) were found between the predicted EMG waveforms and ICs. Using an activation threshold of 3 standard deviations above a resting baseline level, statistically significant (p<0.001) accuracy, sensitivity and specificity measures were found between the predicted EMG waveforms and top r ranked ICs for each of the deep muscles. The values of the 3 statistical measures (accuracy, sensitivity, specificity) for each of the deep muscles were: FPL (0.76, 0.88, 0.70); EPL (0.87, 0.85, 0.91); EPB (0.94, 0.93, 0.94); APL (0.80, 0.87, 0.87). Conclusions: The results indicate that this is the first non-invasive detection of the EMG activity of FPL (D), EPL (D), EPB (D) and APL (D). The ability to detect movement intention as a result of activation from these muscles may be of use for robot based targeted rehabilitation of the hand or in the control of prosthetic hand devices.

Більше джерел

Книги з теми "Deep Invasive Endometriosis (DIE)":

De Nardi, Paola, and Stefano Ferrari. Deep Pelvic Endometriosis. Milano: Springer Milan, 2011. http://dx.doi.org/10.1007/978-88-470-1866-2.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Brandão, Alice, Claudio Peixoto Crispi, and Marco Aurelio Pinho Oliveira, eds. Atlas of Deep Endometriosis. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71697-8.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Nardi, Paola. Deep Pelvic Endometriosis: A Multidisciplinary Approach. Milano: Springer-Verlag Milan, 2011.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Taal, Adriaan Johannes. Integration of neural optical recording and stimulation on minimally invasive, deep-brain implantable CMOS. [New York, N.Y.?]: [publisher not identified], 2022.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Denny, Elaine, Paola De Nardi, and Stefano Ferrrari. Deep Pelvic Endometriosis: A Multidisciplinary Approach. Springer Milan, 2014.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Brandão, Alice, Claudio Peixoto Crispi, and Marco Aurelio Pinho Oliveira. Atlas of Deep Endometriosis: MRI and Laparoscopic Correlations. Springer, 2018.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Brandão, Alice, Claudio Peixoto Crispi, and Marco Aurelio Pinho Oliveira. Atlas of Deep Endometriosis: MRI and Laparoscopic Correlations. Springer, 2018.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Ming-Yuan Wei, Michael, Yanbo Pei, and Yu Gao, eds. Nanomedicine for Deep-Tissue High-Resolution Bio-Imaging and Non-Invasive Therapy. Frontiers Media SA, 2020. http://dx.doi.org/10.3389/978-2-88966-113-8.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Brunoni, Andre Russowsky, Bernardo de Sampaio Pereira Júnior, and Izio Klein. Neuromodulatory approaches for bipolar disorder: current evidences and future perspectives. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0028.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Bipolar disorder is a prevalent condition, with few therapeutic options and a high degree of refractoriness. This justifies the development of novel non-pharmacological treatment strategies, such as the non-invasive techniques of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), as well as the invasive techniques of deep brain stimulation (DBS) and vagus nerve stimulation (VNS). In this chapter, we provide a summary of the development of the techniques as well as the studies carried out with patients with bipolar disorder. Although many promising results regarding the efficacy of theses techniques were described, the total number of studies is still low, highlighting the need of further studies in larger samples as to provide a definite picture regarding the use of clinical neuromodulation in bipolar disorder.

Glannon, Walter. Psychiatric Neuroethics I. Edited by John Z. Sadler, K. W. M. Fulford, and Werdie (C W. ). van Staden. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780198732372.013.30.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Severe psychiatric disorders may be resistant to conventional pharmacological and psychotherapeutic treatments. Invasive interventions such as deep-brain stimulation (DBS) and neurosurgical ablation (lesioning) can modulate dysfunctional neural circuits implicated in these disorders. Yet these two forms of psychiatric neurosurgery are still experimental and investigational and thus their safety and efficacy have yet to be established. This chapter is an examination and discussion of the main ethical issues surrounding the experimental use of DBS and lesioning for treatment-refractory psychiatric disorders. I address questions regarding research subjects’ exposure to risk and informed consent to be enrolled in clinical trials testing these techniques for major depression and obsessive-compulsive disorder. These questions include whether or to what extent the therapeutic misconception influences decisions to enroll in these trials. I then explore similar questions about the use of DBS for schizophrenia and anorexia nervosa. Finally, I discuss the obligations of researchers conducting these studies to research subjects.

Частини книг з теми "Deep Invasive Endometriosis (DIE)":

Tamhane, Nupur, and Emad Mikhail. "Deep-Infiltrating Endometriosis." In Advances in Minimally Invasive Gynecologic Reproductive Surgery, 67–73. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780429198595-7.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Fernandes, Rodrigo, Karolina Afors, and Arnaud Wattiez. "Surgical Treatment of Deep Endometriosis." In Minimally Invasive Gynecology, 105–20. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72592-5_9.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Ceccaroni, Marcello, Giovanni Roviglione, Daniele Mautone, and Roberto Clarizia. "Anatomical Landmarks in Deep Endometriosis Surgery." In Minimally Invasive Gynecology, 45–59. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72592-5_5.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Mabrouk, Mohamed, Diego Raimondo, Alessandro Arena, and Renato Seracchioli. "Anatomically Based Surgical Dissection for Deep Endometriosis Surgery." In Endometriosis, 155–68. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780429488115-9.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Alsalem, Hanan, Jean-Jacques Tuech, Damien Forestier, Benjamin Merlot, Myriam Noailles, and Horace Roman. "Colorectal Surgery for Deep Endometriosis Infiltrating the Bowel." In Endometriosis, 177–90. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780429488115-11.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Kondo, William, Nicolas Bourdel, Monica Tessmann Zomer, and Michel Canis. "Patient Language in Endometriosis Surgery." In Minimally Invasive Gynecology, 79–90. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72592-5_7.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Rosin, Mateus Moreira Santos, and Mauricio Simões Abrão. "Endometriosis: From Diagnosis to Surgical Management." In Minimally Invasive Gynecology, 91–103. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72592-5_8.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

De Nardi, P., and S. Ferrari. "Introduction." In Deep Pelvic Endometriosis, 1–16. Milano: Springer Milan, 2011. http://dx.doi.org/10.1007/978-88-470-1866-2_1.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

De Nardi, P., and S. Ferrari. "Diagnosis." In Deep Pelvic Endometriosis, 17–45. Milano: Springer Milan, 2011. http://dx.doi.org/10.1007/978-88-470-1866-2_2.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

De Nardi, P., and S. Ferrari. "Treatment." In Deep Pelvic Endometriosis, 47–78. Milano: Springer Milan, 2011. http://dx.doi.org/10.1007/978-88-470-1866-2_3.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Тези доповідей конференцій з теми "Deep Invasive Endometriosis (DIE)":

Kasperski, Mariusz, Krzysztof Nowak, Maja Mrugała, Marcin Kalus, and Ewa Milnerowicz –. Nabzdyk. "2022-RA-1046-ESGO Frequency of bowel anastomosis leakage after modified posterior exenteration – comparison of two surgical Methods: classic surgery in patients with ovarian cancer and minimal invasive modified ‘tailored’ technique in deep infiltrating endometriosis patients." In ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.852.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Loh, M., C. Goh, and Y. Lim. "EP732 Bladder endometriosis mimicking invasive pelvic malignancy." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.785.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Figueredo, Weslley K. R., Italo F. S. da Silva, João O. B. Diniz, Aristófanes C. Silva, Anselmo C. de Paiva, Alice C. C. Brandão Salomão, and Marco A. P. de Oliveira. "Abordagem Computacional Baseada em Deep Learning para o Diagnóstico de Endometriose Profunda através de Imagens de Ressonância Magnética." In Simpósio Brasileiro de Computação Aplicada à Saúde. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/sbcas.2023.229567.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Endometriose é uma doença que atinge vários órgãos, principalmente aqueles na estrutura pélvica, e reduz consideravelmente a qualidade de vida da pessoa afetadas. A doença afeta, principalmente, mulheres em idade fértil. Pode ser identificada via exames de imagem. Neste trabalho, Propõe-se um método para identificação automática da lesão de endometriose em imagens de ressonância magnética usando técnicas de processamento de imagem e uma VGG-16 modificada, a fim de servir como auxílio no diagnóstico, na redução da necessidade da utilização de métodos invasivos para realização destes, o tempo de diagnóstico e os resultados falsos negativos. Acurácia de 83,89%, sensibilidade de 84,15%, e especificidade de 83,86% foram alcançadas.

Grammatikakis, K., A. Theodoropoulou, E. Halkia, and K. Patsouras. "457 Deep infiltrating endometriosis: neoplasm or benign condition?" In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.150.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Araujo, Sergio Eduardo Alonso, Rodrigo Moisés de Almeida Leite, Gustavo Yano Callado, Leandro Cardoso Barchi, Ana Sarah Portilho, and Bruno Zilberstein. "DEEP INTESTINAL ENDOMETRIOSIS INFILTRATING THE URETER – SURGICAL MANAGEMENT." In 71° Congresso Brasileiro de Coloproctologia. Thieme Revinter Publicações Ltda., 2023. http://dx.doi.org/10.1055/s-0044-1781255.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Balica, Adrian, Jennifer Dai, Kayla Piiwaa, Xiao Qi, Ashlee N. Green, Nancy Phillips, Susan Egan, and Ilker Hacihaliloglu. "Augmenting endometriosis analysis from ultrasound data using deep learning." In Ultrasonic Imaging and Tomography, edited by Nick Bottenus and Christian Boehm. SPIE, 2023. http://dx.doi.org/10.1117/12.2653940.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Satorres, Elena, Victor Lago, Irene Juarez, Blas Flor, Santiago Domingo, and Vicente Payá. "211 Ghost ileostomy after rectal resection in patients with deep infiltrating endometriosis." In ESGO 2024 Congress Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/ijgc-2024-esgo.495.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Shah, Aman, Amal Mehta, Michael Wang, Neil Neumann, Avideh Zakhor, and Timothy McCalmont. "Deep learning segmentation of invasive melanoma." In Digital and Computational Pathology, edited by John E. Tomaszewski and Aaron D. Ward. SPIE, 2023. http://dx.doi.org/10.1117/12.2654672.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Schacht, Stephan, Clemens Schütt, Christoph Strehse, and Sascha Kosleck. "Minimally Invasive Vertical Deep-Sea Mining." In OCEANS 2023 - MTS/IEEE U.S. Gulf Coast. IEEE, 2023. http://dx.doi.org/10.23919/oceans52994.2023.10337374.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

ten Cate, J. W., M. V. Huisman, and H. R. Buller. "DIAGNOSIS OF DEEP VENOUS THROMBOSIS: NON-INVASIVE VS INVASIVE DIAGNOSTIC PROCEDURES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642967.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

The clinical diagnosis of deep vein thrombosis (DVT) in symptomatic patients is unreliable. The need for objective diagnostic tests is widely acknowledged. Contrast venography in experienced hands is considered to be the reference method. This method is invasive, uncomfortable to the patient, not easily repeatable and expensive.For this reason several non-invasive tests have been developed and evaluated recently. Of the non-invasive tests impedance plethysmography (IPG) has been thoroughly evaluated in properly designed prospective clinical trials. Serial IPG in symptomatic outpatients is safe and effective. It was shown in longterm follow-up that anticoagulant treatment could be safely withheld in over 500 patients with repeatedly normal IPG (0.3-0.6% recurrence DVT). The specificity for proximal DVT was 92%. The feasability of IPG in symptomatic outpatients was over 95%. The safety of withholding anticoagulant treatment in symptomatic inpatients with a serial normal IPG is an unresolved issue. Preliminary results show that a similar sensitivity might be obtained in inpatients, however, the feasability was lower (87%).Doppler ultrasound has been studied extensively, however, there is a great variation in reported sensitivity for proximal DVT due to the lack of objective diagnostic criteria and the safety of withholding anticoagulant treatment in patients with serial normal Doppler tests results is not es tablished.strain gauge plethysmography has not been evaluated properly and therefore awaits further studies. 125I-fibrinogen legscanning has been shown to be sensitive for calf vein thrombosis (over 90%). In combination with IPG this method is a safe and effective alternative to venography.Radionuclide phlebography has never been evaluated in prospective clinical trials in a broad spectrum of symptomatic patients, and can therefore not be recommended for routine use.It is concluded that presently the management of patients with clinically suspected DVT should be performed with the use of serial IPG, IPG in combination with 125I—fibrinogen legscanning or contrast venog raphy.

Звіти організацій з теми "Deep Invasive Endometriosis (DIE)":

Vanhie, Arne, Ellen Caron, Eveline Vermeersch, Dorien O, Carla Tomassetti, Christel Meuleman, Pieter Mestdagh, and Thomas D'Hooghe. Circulating microRNAs as non-invasive biomarkers in endometriosis diagnosis – a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2024. http://dx.doi.org/10.37766/inplasy2024.1.0066.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Kelley, Mark. TASK 4 (FIELD TESTING) REPORT. A Non-Invasive Approach for Elucidating the Spatial Distribution of in-situ Stress in Deep Subsurface Geologic Formations Considered for CO2 Storage. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1890653.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Kelley, Mark, Odd Andersen, and Valerie Smith. TASK 5 REPORT FIELD SCALE STRESS MODELING: A Non-Invasive Approach for Elucidating the Spatial Distribution of In Situ Stress in Deep Subsurface Geologic Formations Considered for CO2 Storage. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1890654.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Kelley, Mark, Bob Hardage, Andrew Bunger, and Odd Andersen. FINAL REPORT: A Non-Invasive Approach for Elucidating the Spatial Distribution of In-Situ Stress in Deep Subsurface Geologic Formations Considered for CO<sub>2</sub> Storage. Office of Scientific and Technical Information (OSTI), December 2021. http://dx.doi.org/10.2172/1836647.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Bunger, Andrew, Mark Kelley, and Delal Gunaydin. TASK 3 REPORT LABORATORY CHARACTERIZATION OF STRESS DEPENDENT WAVESPEED: A Non-Invasive Approach for Elucidating the Spatial Distribution of In-Situ Stress in Deep Subsurface Geologic Formations Considered for CO2 Storage. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1890651.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Kelley, Mark, Bob Hardage, Valerie Smith, Allen Modroo, and Richard Dok. TASK 2 REPORT EXTRACTING STRESS DATA FROM SEISMIC DATA: A Non-Invasive Approach for Elucidating the Spatial Distribution of In Situ Stress in Deep Subsurface Geologic Formations Considered for CO2 Storage. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1890650.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Leis, Sherry, and Lloyd Morrison. Plant community trends at Tallgrass Prairie National Preserve: 1998–2018. National Park Service, October 2022. http://dx.doi.org/10.36967/2294512.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

The Heartland Inventory and Monitoring Network monitors plant communities at Tallgrass Prairie National Preserve and evaluates a variety of environmental variables that aﬀect vegetation patterns, including climate and ecological disturbances such as ﬁre and grazing. Here we report on 2002–2018 trends in management actions (ﬁre and grazing) and key plant community indicators. Temperature has increased over the past 50 years in the region. Precipitation and a standardized precipitation-evapotranspiration index included a high degree of interannual variability and did not demonstrate directional change. We documented a decline in disturbance intensity (i.e., less frequent prescribed ﬁre and lower stocking rates) since 2006. A preserve goal is to maintain 30 to 60% of the area as bare ground (soil and rock) for ideal greater prairie-chicken habitat. Bare areas have been in decline and minimally meet the goal preserve wide. Bare areas vary by pasture and year, with bare areas exceeding the threshold in earlier years and Big Pasture and Red House Pasture falling short in some recent years. Although the preserve-scale mean minimally met the objective, there was a great deal of heterogeneity across monitoring sites. Litter cover and depth were greater than ecological recommendations for the greater prairie-chicken, especially in 2018. Litter depth demonstrated a great deal of variability and included deep litter. Woody plants were targeted to remain below 5% cover. Preserve- and pasture-scale cover means were well below this threshold but are increasing. Species richness on a per site basis (alpha diversity) and preserve-wide richness (gamma diversity) showed no apparent directional change when corrected for diﬀerences in sample size. Comparison of native species composition between 2002 and 2018 revealed a 36.9% diﬀerence in the Sørensen Index, although observer error accounted for almost 2/3 of this apparent change. The preserve continues to have characteristic tallgrass prairie species, and nonnative species continue to be low. Similar to targeted invasive plant monitoring, we found the target species Kentucky bluegrass to be below park thresholds. Continued evaluation of ﬁre frequency and grazing intensity will be critical to achieving ecological goals including conserving the greater prairie-chicken. Development of a grazing plan may assist with prescribing stocking rates that are consistent with the preserve’s ecological and cultural objectives and could include alternative herbivores, such as goats or expansion of bison.