Дисертації з теми "Decoy molecules"
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Bryant, William Barton. "Caspases and caspase regulators in Lepidoptera and Diptera." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2612.
Повний текст джерелаHowle, Christopher Roy. "Decay processes of photoexcited molecules in the VUV : comparison with ion/molecule reactions." Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421712.
Повний текст джерелаRennie, Emma E. "Decay mechanisms of photoexcited molecular ions." Thesis, Heriot-Watt University, 1997. http://hdl.handle.net/10399/658.
Повний текст джерелаMendive, Tapia David. "Computational modelling of excited state decay in polyatomic molecules." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11149.
Повний текст джерелаXiong, Ting. "Modeling of Decay Rate for Molecules at an Island Surface." PDXScholar, 1995. https://pdxscholar.library.pdx.edu/open_access_etds/5198.
Повний текст джерелаBeelman, Clare Ann 1969. "The control ofmRNA decay in Saccharomyces cerevisiae." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/289588.
Повний текст джерелаTucker, Morgan Dean. "Deadenylation and mRNA decay in Saccharomyces cerevisiae." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/289856.
Повний текст джерелаVigrow, Anne. "Molecular analysis of the dry rot fungus Serpula lacrymans." Thesis, University of Abertay Dundee, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306791.
Повний текст джерелаFerraiuolo, Maria A. "The role of eIF4AIII and 4E-T in mRNA decay /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103156.
Повний текст джерелаDougherty, Julie Ann. "Decay of Beta-Globin mRNA in Erythroid Cells." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397499022.
Повний текст джерелаButh, Christian. "Non-Hermitian perturbation theory for the electronic decay of excited and ionized molecules and identification of the electronic decay processes in the Auger decay of core-ionized Xenon-Fluorides." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10236341.
Повний текст джерелаPresnyak, Vladimir. "Effects of Codon Usage on mRNA Translation and Decay." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1427387336.
Повний текст джерелаMcDowell, Helen Elizabeth. "Molecular analysis of wet rot organisms : application to conservation of maritime artifacts." Thesis, University of Abertay Dundee, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316045.
Повний текст джерелаKinney, Emma. "Decoupling of HSV1 Vhs protein mRNA decay and translation stimulation." Thesis, University of Missouri - Kansas City, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1543940.
Повний текст джерелаHerpes Simplex Virus Type 1 is a member of the alphaherpesvirinae subfamily within the family Herpesviridae. This virus has both a lytic and latent cycle. Primary infection occurs when the virus enters epithelial cells around the mucosal lining of the nose and mouth. Within the epithelial cells, the virus undergoes an active lytic infection, causing an ulcerated blister, more famously known as a 'cold sore' or 'fever blister'. Once HSV enters the nearby sensory neurons the genome is transported to the neuronal cell body where its latency associated transcripts are activated and the virus remains in a dormant latent cycle until reactivation, when the virus is transported back down the axon to the epithelial cells at or near the site of initial infection. The Virion Host Shutoff protein is a tegument protein from HSV1 and acts as a ribonuclease, degrading both cellular and viral mRNAs, making the course of viral infection more efficient. A study by Saffran, Read and Smiley uncovered an unexpected new function of Vhs: stimulation of translation from some IRESs. An IRES is a section of mRNA with a high level of secondary structure, capable of inducing cap-independent translation. In similar experiments utilizing a bicistronic reporter transcript, I sought to discover whether or not these two functions of the Vhs protein could be de-coupled. Experiments involved dually transfecting HeLa cells with different Vhs mutants across a range of Vhs plasmid concentrations and the bicistronic reporter construct. Levels of reporter activity were measured from cell lysates 36 hours after transfections and provided a measurement of the control at the level of translation. As the cellular Bip IRES element was present between the cistrons, the 3' cistron provided a measure of IRES stimulation. The Results revealed examples of Vhs mutants in which the two activities had been separated. It is unknown what role IRES stimulation could play during Herpesvirus infection, although it is interesting to note that some HSV1 genes have IRES like elements within the 5' UTR. Future experiments can be done to investigate whether or not Vhs is actively recruiting transcription initiation factors to these IRES elements.
Mazzochette, Mark Joseph. "Shedding Light on Decay Kinetics of Critical Wastewater Bacteria with Molecular Tools." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/23165.
Повний текст джерелаMaster of Science
Richards, Elliott Grant. "The Role of Decay Accelerating Factor in the Pathogenesis of Endometriosis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619689609524397.
Повний текст джерелаStewart, Beverly. "Computational chemistry applied to the excited state decay of molecular photonic devices." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538922.
Повний текст джерелаCaló, A. (Antonio). "Electron spectroscopy of atoms and molecules using synchrotron radiation, UV radiation and electron impact." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514286650.
Повний текст джерелаChen, Ying-Hsin. "UNDERSTANDING MECHANISMS THAT COUPLE TRANSLATION ELONGATION AND MRNA DECAY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522684403630693.
Повний текст джерелаWatkin, S. "Excitation and decay of stark mixed n=2 states of atomic hydrogen." Thesis, University of Stirling, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354060.
Повний текст джерелаBucci, Robert Joseph. "Molecular based identification of wood decay fungi from two field sites in Mississippi." Master's thesis, Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-06182008-141603.
Повний текст джерелаSkoglund, Lena. "Molecular Mechanisms of Frontotemporal Lobar Degeneration." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9550.
Повний текст джерелаNoah, Ramsey S. "Bimolecular recombination and complete photocurrent decay in metallophthalocyanine thin films." California State University, Long Beach, 2013.
Знайти повний текст джерелаThomas, Marshall Peter. "Novel Roles for Ribonucleic Acids in Programmed Cell Death." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094353.
Повний текст джерелаKopelke, Sören [Verfasser], and Lorenz S. [Akademischer Betreuer] Cederbaum. "Quenching of Molecular Photodissociation by Interatomic Coulombic Decay / Sören Kopelke ; Betreuer: Lorenz S. Cederbaum." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/117978300X/34.
Повний текст джерелаSerdar, Lucas D. "The Functional Relationship between the Nonsense-Mediated mRNA Decay Pathway and the Prematurely Terminating Ribosome." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1554304118763865.
Повний текст джерелаHendricks, Gabriel L. "Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/674.
Повний текст джерелаDorstyn, Loretta Esterina. "The identification and characterisation of two novel Drosophila caspases, DRONC and DECAY." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phd718.pdf.
Повний текст джерелаYang, Feng. "Endoribonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polysome-bound substrate." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111267563.
Повний текст джерелаTitle from first page of PDF file. Document formatted into pages; contains xviii, 216 p.; also includes graphics (some col.) Includes bibliographical references (p. 196-216). Available online via OhioLINK's ETD Center
Inhester, Ludger [Verfasser], Helmut [Akademischer Betreuer] Grubmüller, Jörg [Akademischer Betreuer] Enderlein, and Ulf [Akademischer Betreuer] Saalmann. "Auger decay in double core ionized molecules / Ludger Inhester. Gutachter: Helmut Grubmüller ; Jörg Enderlein ; Ulf Saalmann. Betreuer: Helmut Grubmüller." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044768398/34.
Повний текст джерелаSchnorr, Kirsten [Verfasser], and Robert [Akademischer Betreuer] Moshammer. "XUV Pump-Probe Experiments on Electron Rearrangement and Interatomic Coulombic Decay in Diatomic Molecules / Kirsten Schnorr ; Betreuer: Robert Moshammer." Heidelberg : Universitätsbibliothek Heidelberg, 2014. http://d-nb.info/1177811189/34.
Повний текст джерелаJia, Jieshuang. "Study of molecules with nonsense mutation correction capacity." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S009/document.
Повний текст джерелаNonsense mutations represent approximately 10% of mutations found in the inherited geneticdiseases. mRNAs harboring a nonsense mutation are rapidly degraded by a quality-controlmechanism called nonsense-mediated mRNA decay (NMD) to prevent the synthesis of toxic or nonfunctionaltruncated proteins. Some stratégies have been developed to correct nonsense mutations.In our lab, we study 2 of them which are (i) the NMD inhibition and (ii) the PTC-readthroughactivation which is a mechanism leading to the incorporation of an amino-acid at the PTC position. Todesign new therapeutic tools for the inherited genetic diseases, our lab tested molecules byscreening to find ones with the capacity of NMD inhibition. For each molecules selected in thescreen, we measure the efficiency of NMD inhibition and PTC-readthrough activation of thesemolecules in cell lines harboring a nonsense mutation. We have shown that amlexanox not onlyinhibits NMD but also activâtes PTC readthrough. But the efficacy of amlexanox is still low. Wewanted to find other families of molecules capable of rescuing the expression of nonsense mutationcontainingmRNA with a higher efficacy or with some specificity. In my study, I found two spécialfamilies, one is the family of apoptosis inducers and the other is the family of cytoskeleton inhibitors.I found that apoptosis inducers can inhibit NMD by activating caspase pathway and cleave NMDfactors (UPF1 and UPF2). I also found that cytoskeleton inhibitors can inhibit NMD and some of themcan activate PTC-readthrough by inducing NMD factors (UPF1 or/and UPF3X) to concentrate in Pbodiesor in other cytoplasmic foci. The efficiencies of these molecules on NMD inhibition are similaror higher than amlexanox. Apoptosis inducers and cytoskeleton inhibitors demonstrated thatmolecules which can inhibit NMD or/and activate PTC-readthrough can be found and candemonstrate a higher correction of nonsense mutation efficiency than the existing molecules(ataluren or amlexanox for example)
Perrie, W. "Polarisation correlation in the two-photon decay of metastable atomic deuterium and a test of Bell's inequality." Thesis, University of Stirling, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370538.
Повний текст джерелаGunnell, Mark K. "The Detection and Molecular Evolution of Francisella tularensis Subspecies." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5696.
Повний текст джерелаSmith, Jenna E. "Investigation of the mRNP and Transcriptome Regulated by Nonsense-Mediated RNA Decay." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1421428941.
Повний текст джерелаLopes, Josiane Millani. "Podzols of Ilha Comprida (SE, Brazil): organic matter chemistry and decay features." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/11/11140/tde-03052016-185358/.
Повний текст джерелаOs solos mais frequentes na Planície Costeira do Estado de São Paulo são os podzóis, caracterizados por podzolização com hidromorfismo forte a moderado a bem drenado com horizontes B-podzol muito bem desenvolvidos (Bh ou Bhm). O processo de podzolização inclui os efeitos da hidrologia e do enraizamento no perfil e os efeitos subsequentes da drenagem melhorada. Uma crono-hidrosequencia de podzóis foi descrita em detalhes em um barranco na costa sul da Ilha Comprida, uma ilha barreira do Holoceno, e permitiu uma subdivisão em quatro grupos distintos: perfis mal drenados, perfis com horizonte B bem drenados, perfis fortemente enraizados e perfis superpostos. A descrição morfológica e algumas observações sobre o barranco exposto foram essenciais para o agrupamento e diferenciar os perfis de podzóis. Alguns desses podzóis bem drenados possuem manchas esbranquiçadas que estão relacionadas com a seletiva decomposição da matéria orgânica (MO) por microorganismos. Tais manchas são freqüentemente associadas aos canais radiculares. Foram estudados dezessete perfis, dos quais treze apresentaram manchas de esgotamento espalhadas ao longo do perfil. A maioria destas manchas são esbranquiçadas e estão localizadas preferencialmente nos horizontes de transição entre os horizontes E e B, particularmente em condições de boa drenagem. Tais manchas possuem algumas diferenças morfológicas e puderam ser agrupadas de acordo com semelhanças na sua morfologia e da sua posição no perfil. Os grupos são: (a) manchas concêntricas de depleção da MO; (b) manchas circulares/tubularess de depleção da MO (tocas); (c) manchas pontilhadas de depleção da MO; (d) manchas fantasmas de depleção da MO; (e) manchas irregulares de depleção da MO; e (f) manchas de depleção de Fe. A composição química da matéria orgânica do solo foi estudada em detalhe por pirólise em combinação com cromatografia em fase gasosa/espectrometria de massa (Py-CG/EM). Amostras de todos os horizontes dos perfis estudados foram coletadas, bem como amostras do centro das manchas (M) e do solo adjacente (S). Os processos envolvidos na gênese de podzóis da planície costeira arenosa estão diretamente relacionados com a drenagem, a contribuição de matéria orgânica dissolvida (MOD), a contribuição de matéria orgânica derivada de raízes, a composição química da matéria orgânica e sua decomposição por microorganismos, causando uma grande variação no podzóis. Os podzóis bem drenados diferem em características dos mal drenados em composição e deposição de MO, bem como a sua decomposição, que está directamente relacionada com a actividade dos grupos de microrganismos. Eles também diferem na contribuição relativa da MO derivada de raízes e MOD. Existe uma grande variação nas características da decomposição por microorganismos entre os perfis de podzóis permanentemente expostas ao ar e spray marinho (falésias) na Ilha Comprida e os do interior (trincheiras). Há, portanto, dois processos principais que alteram a morfologia de podzóis (composição da MO): (a) mudança na drenagem e enraizamento, e (b) a exposição ao ar.
Kamelgarn, Marisa Elizabeth. "MUTATIONS OF FUS CAUSE AGGREGATION OF RNA BINDING PROTEINS, DISRUPTIONS IN PROTEIN SYNTHESIS, AND DYSREGULATION OF NONSENSE MEDIATED DECAY." UKnowledge, 2019. https://uknowledge.uky.edu/toxicology_etds/27.
Повний текст джерелаMaximowitsch, Egle [Verfasser], and Tatiana [Akademischer Betreuer] Domratcheva. "Molecular mechanisms of spectral tuning and excited-state decay in phytochrome photoreceptors / Egle Maximowitsch ; Betreuer: Tatiana Domratcheva." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1210647702/34.
Повний текст джерелаForrest, Megan E. "Regulation of Mammalian Messenger RNA Stability via the Open Reading Frame." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1579862741902687.
Повний текст джерелаGangras, Pooja. "Understanding the Role of Exon Junction Complex-dependent Nonsense Mediated mRNA Decay in Zebrafish Embryonic Development." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574765848602854.
Повний текст джерелаZagorodskikh, Sergey. "Single-photon multiple ionisation of atoms and molecules investigated by coincidence spectroscopy : Site-specific effects in acetaldehyde and carbon dioxide." Doctoral thesis, Uppsala universitet, Molekyl- och kondenserade materiens fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301128.
Повний текст джерелаByte av lokal vid disputation till Polhemssalen.
Woodward, Lauren A. "Examining the Effects of Translation on the Exon Junction Complex." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574724716785331.
Повний текст джерелаUwimpuhwe, Henriette. "Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3208.
Повний текст джерелаIncludes bibliographical references (leaves 73-83).
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory injury at the NMJ. Decay Accelerating Factor (DAF), a member of complement regulatory proteins, prevents activation of autologous components of complement pathways. The absence of DAF, in knock-out mouse models, has been shown to significantly increase the susceptibility to experimental autoimmune MG. A previous study showed that a high proportion of South African MG patients of African genetic ancestry develop immunosuppressive therapyresistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury.
Bulat, Muhammer. "Molecular cluster cations of carbon monoxide and carbon dioxide." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16246.
Повний текст джерелаThis thesis deals with the metastable decay and the surface scattering in the hyperthermal energy range of relatively weakly bound molecular cluster cations. With carbon monoxide and carbon dioxide two related model systems were chosen for a systematic size dependent study. Surface impact experiments were carried out with stainless steel and silicon surfaces. Results were obtained by a new, reflectron time-of-flight mass spectrometer (Re-TOFMS). Additional to the experimental data we present in this work a detailed description of the instrumental design considerations, numerical optimization, ion optical simulations. Hence each ion optical component like electron guns, accelerator, deflector, mass gate and reflectron are described. Despite the compact dimensions with a total flight length of ~1.5m the developed instrument possesses a high mass resolution above m/Delta m = 3000. Additionally it offers the possibility to perform mass separation of big cluster ions with sizes n
Guedes, Ana Raquel Dias Pereira. "The role of SMG6 and PM/Sc 100 ribonucleases in messenger RNA degradation mechanisms." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17151.
Повний текст джерелаEukaryotic gene expression comprises a series of interconnected steps, from transcription to protein synthesis, in which messenger RNAs (mRNAs) are the key intermediates. While the multitude of events that take place throughout the whole process allows for the production of proteins to be controlled at many levels, ensuring maximum efficiency and fidelity, it also makes gene expression susceptible to errors. Eukaryotic cells have developed intricate mRNA quality control mechanisms that recognize and degrade aberrant transcripts. Two examples of these mechanisms are the nonsense-mediated mRNA decay (NMD), which targets mRNAs with premature translation termination codons (PTCs), and the nonstop mRNA decay (NSD), which eliminates mRNAs lacking any in-frame translation termination codons. SMG6 and PM/Scl100 are both ribonucleases which have been implicated in mRNA degradation pathways. One of the mechanisms proposed for mammalian NMD involves an endonucleolytic cleavage of transcripts in the vicinity of the PTC catalyzed by SMG6. On the other hand, the human exosome, which includes the catalytic subunit PM/Scl100, has been associated not only with mRNA surveillance mechanisms, but also with normal mRNA turnover. However, questions relative to the specificity or indispensability of these enzymes in the pathways in which they participate have not yet been answered. The present work aimed to explore the role of SMG6 and PM/Scl100 ribonucleases in the degradation of normal or NSD- and NMD-sensitive mRNAs. The results obtained point to the involvement of SMG6, not only in NMD, but also in NSD and normal mRNA turnover. Moreover, they suggest that SMG6 plays an indirect role on the degradation of NMD targets. PM/Scl100 also appears to intervene in NMD, NSD and normal mRNA turnover; however, the results herein presented suggest that the main contribution to NMD-eliciting transcripts 3’→5’ degradation may be offered by other exoribonucleases.
A expressão génica em eucariotas envolve uma série de etapas interligadas, desde a transcrição do material genético até à síntese da proteína correspondente, nas quais os RNAs mensageiros (mRNAs) são os intermediários cruciais. Embora a panóplia de eventos que ocorrem ao longo de todo o processo permita que a produção proteica seja controlada a vários níveis, também torna a expressão génica vulnerável a erros. As células eucarióticas desenvolveram mecanismos elaborados de controlo de qualidade do mRNA que reconhecem e degradam transcritos anómalos. Dois exemplos destes mecanismos são o decaimento do mRNA mediado por mutações nonsense (NMD), que detecta mRNAs com codões de terminação da tradução prematuros (PTCs), e o decaimento do mRNA nonstop (NSD), que elimina mRNAs que não possuem codões de terminação da tradução em fase na grelha de leitura. A SMG6 e a PM/Scl100 são ambas ribonucleases já implicadas em vias de degradação de mRNAs. Um dos mecanismos propostos para o NMD em mamíferos envolve a clivagem endonucleolítica dos transcritos na proximidade do PTC, catalizada pela SMG6. Por outro lado, o exossoma humano, que inclui a subunidade catalítica PM/Scl100, já foi associado não só a mecanismos de vigilância do mRNA, mas também ao turnover do mRNA. No entanto, questões relativas à especificidade ou indispensabilidade destas enzimas nos mecanismos nos quais participam ainda não têm resposta. O presente trabalho teve como objectivo explorar o papel das ribonucleases SMG6 e PM/Scl100 na degradação de mRNAs normais ou sensíveis ao NSD e ao NMD. Os resultados obtidos apontam para o envolvimento da SMG6, não só no NMD, mas também no NSD e no turnover do mRNA. Para além disso, sugerem também que a SMG6 desempenha um papel indirecto na degradação de alvos do NMD. A PM/Scl100 também parece intervir no NMD, no NSD e no turnover do mRNA; no entanto, os resultados aqui apresentados sugerem que a principal contribuição para a degradação 3’→5’ de transcritos que desencadeiam o NMD é oferecida por outras exoribonucleases.
Sweet, Thomas Jeffrey. "New Insights Into the Relationship Between Messenger RNA Translation and Degradation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1321298653.
Повний текст джерелаRåberg, Ulrika. "Fungal degradation and discolouration of Scots pine : a molecular approach /." Uppsala : Swedish University of Agricultural Sciences, 2006. http://diss-epsilon.slu.se/archive/00001268/.
Повний текст джерелаThesis documentation sheet inserted. Errata sheet inserted. Appendix reprints four papers and manuscripts co-authored with others. Includes bibliographical references. Issued also electronically via World Wide Web in PDF format; online version lacks appendix.
Hassan, Faizule. "Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1511449587326648.
Повний текст джерелаMerrikh, Christopher N. "Characterization of New Factors in the 18S Nonfunctional Ribosomal RNA Decay Pathway in S. cerevisiae: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/613.
Повний текст джерелаBeaulieu, Samuel. "Probing femtosecond and attosecond electronic and chiral dynamics : high-order harmonic generation, XUV free induction decay, photoelectron spectroscopy and Coulomb explosion." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0063/document.
Повний текст джерелаThis thesis manuscript is articulated around the investigation of the interaction between ultrashort light pulses and gas-phase atoms, polyatomic and chiral molecules. Using the toolboxes developed in attosecond and strong-field physics as well as in femtochemistry, our general goal is to reach a better understanding of subtle effects underlying ultrafast light-induced dynamics in matter.To do so, we developed cutting-edge near-infrared and mid-infrared few-cycle light sources, which were used to build a water-window soft-X-ray source based on high order harmonic generation (HHG), as well as to study new HHG channels involving highly-excited (Rydberg) states. The latter study revealed a delayed HHG emission from the ionization of Rydberg states and radiative recombination onto the electronicground state, triggering our interest in the role of Rydberg states in strong-field physics. This led us to investigate the laser-induced XUV Free Induced Decay from electronic wave packets as a new background-free 2D spectroscopic technique.More over, we have found out that strong-field interaction with a well prepared coherent superposition of electronic states led to the generation of hyper-Ramanlines concomitant with standard high-order harmonics. These spectral features were predicted in the early-days theoretical calculations of HHG but had never been reported experimentally.After these experiments in rare gas atoms, we moved to molecular targets, in whichlight-induced electronic excitation can trigger nuclear dynamics. Using simple benchmark molecules, we have studied dynamics involving the participation of both nuclear and electronic degrees of freedom: first, we studied the ultrafast non adiabatic photoisomerization of the acetylene cation into vinylidene cation, andsecond, we investigated the coherent control of electron localization during molecular photodissociation of H2+. The simplicity of these molecular targets enabled the comparison of the experimental results with state-of-the-art theoretical calculations,revealing the importance of the coupling between nuclear and electronic degrees of freedom in photoinduced molecular dynamics.The other major pillar of this thesis is the study of ionization of chiral molecules usingchiral light pulses. It has been known since the 70s that the ionization from an ensemble of randomly oriented chiral molecules, using circularly polarized light pulse,leads to a strong forward-backward asymmetry in the number of emitted photoelectrons, along the light propagation axis (Photoelectron Circular Dichroism,PECD). Prior to this thesis, PECD was widely studied at synchrotron facilities (single photonionization) and had recently been demonstrated using table-top lasers in resonant-enhanced multiphoton ionization schemes. In this thesis, we have shownthat PECD is a universal effect, i.e. that it emerges in all ionization regimes, from single photon ionization, to few-photon ionization, to above-threshold ionization, up to the tunneling ionization regime. This bridges the gap between chiral photoionizationand strong-field physics. Next, we have shown how the combination of standard femtochemistry approaches and PECD can be used to follow the dynamics of photoexcited chiral molecules using time-resolved PECD. Using similar experimental approaches, but by using pulse sequences with counter-intuitive polarization states,we have demonstrated a novel electric dipolar chiroptical effect, called Photoexcitation Circular Dichroism (PXCD), which emerges as a directional and chirosensitive electron current when multiple excited bound states of chiral molecules are coherently populated with chiral light. Last, we introduced a time-domain perspective on chiral photoionization by measuring the forward-backward asymmetry of photoionization delays in chiral molecules photoionized by chiral light pulses. Our work thus carried chiral-sensitive studies down to the femtosecond and attosecond ranges