Дисертації з теми "Dcxx"
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Hussain, Ishfaq. "Scalable Device Mobility – Mobile DCXP." Thesis, Mittuniversitetet, Avdelningen för informations- och kommunikationssystem, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-23324.
Повний текст джерелаYu, Oscar. "Improvements of Synchronous Rectification on LLC-DCX." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/85238.
Повний текст джерелаMaster of Science
This research explores issues and improvements in synchronous rectifiers used in resonant based power conversion circuits. The two issues explored hurt rectifier efficiency, and thus total power conversion circuit efficiency. Implementation issues are identified, simulated, and new solutions are proposed. Simulations are run to quantify the amount of power savings is possible.
Florentini, Carranza Edgar Alejandro. "Niveles de expresión de DCXR en tejido gonadal de alpacas macho." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/9959.
Повний текст джерелаEstudia a un marcador del potencial de fertilidad, la dicarbonilo, L-xilulosa reductasa (DCXR) cuya utilidad ha sido descrita para explicar hasta el 14% de casos de infertilidad, según lo descrito en estudios clínicos para humanos. Se evalúa la expresión del gen DCXR, mediante RT-qPCR, en epidídimos de machos de alpaca en edad fértil (n = 39) y, se determinó la correlación con parámetros de fisiología espermática evaluados en el laboratorio. Al igual que en humanos, DCXR muestra asociación estadística únicamente con la capacidad de los espermatozoides de alpaca de unirse a la zona pelúcida homóloga (prueba de Spearman, p< 0,05). No se encuentra asociación significativa (prueba de Spearman, p>0,05) con otros parámetros de fisiología espermática. El gen DCXR puede, entonces, ser utilizado en alpacas macho como un marcador del potencial de fertilidad, que junto a otros marcadores moleculares, formaría parte del panel de biomarcadores predictivos para determinar el potencial de fertilidad en alpacas.
Tesis
Akintayo, Ayodélé. "La Dicarbonyl L-xylulose réductase (DCXR) dans l'épididyme : une enzyme, plusieurs fonctions." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26208.
Повний текст джерелаThe epididymis is a complex organ involved in spermatozoa maturation and acquisition of their fertilization abilities. The epididymis is segmented in different regions with specific gene expression patterns. DCXR gene, found in many species, is highly conserved during the evolution. The DCXR protein is involved in different biological processes of which, the inositol degradation energetic pathway. DCXR is highly expressed in the epididymis of studied species (mouse, hamster, monkey, human). In human, DCXR protein is found on the spermatozoa and is important for the binding of spermatozoa to the oocyte. The lack of this protein has been correlated with idiopathic infertility cases. We hypothesized that the high sequence homology of DCXR between species is associated with functionally conserved properties of the protein in mediating sperm-oocyte binding. We further hypothesized that the DCXR protein sequence contains specific functional domains that permit its multiple biological roles. We used the murine, human and bovine models for our studies. Bovine is a model in which the fertility can be quantified, what makes it interesting for the study of protein involved in fertilization. We report here the identification of DCXR in bull epididymis. The protein is highly expressed in the epididymis but shows expression and localization differences with the human counterpart. In the bovine epididymis, we identify the gene expression of enzymes involved in the inositol degradation metabolic pathway. The recombinant DCXR protein and the epididymis fluids xylitol dehydrogenase enzymatic activity, suggest the involvement of the protein in energy production by means of the inositol degradations pathway. By point mutations induction in the human DCXR, we revealed the protein domains involved in its enzymatic properties. Preliminary experiments did not conclusively demonstrate a role for DCXR during sperm-zona pellucida binding and a pilot test to create a DCXR-null animal model was unsatisfactory. Therefore, future research should focus on elucidating the function of this protein on male reproductive function. All together our results suggest a difference in the role of DCXR depending on the species studied.
Lenormand, Pascal. "Etude de l'évolution microstructurale de précurseurs d'oxyde de zirconium à l'état de gel, xérogel, couche mince et aérosol par diffusion de rayons X." Limoges, 2001. http://www.theses.fr/2001LIMO0043.
Повний текст джерелаIn this work, we are interested in zirconia precursors synthesised by the sol gel method : gel, xerogel, thin film and aerogel. The objective is to precise the specific role of the various states of aggregation of the elementary particles constituting these precursors on the evolution of their microstructure during a low temperature thermal processing
Guichet, Pierre-Olivier. "Rôle de NKX2-2, NGN2 et DCX dans la prolifération, différenciation et migration des cellules tumorales de glioblastomes." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20143.
Повний текст джерелаGlioblastomas (GB) are the most common primary tumors of the CNS and are particularly resistant to radio/chemotherapy. They generally have a solid and infiltrative component. The latter being difficult to remove by surgery will be partly responsible for tumor recurrence. One of the major advances in the field is highlighted in the Gb of subpopulations with features of neural precursors. Cancer cells use specific gene networks to maintain their proliferation and undifferentiated state. One approach to eliminate these cancer cells would be to target transcription factors involved in the proliferation or to force their differentiation. To this end, I studied the role of NKX2.2 and NGN2 from 3 primary multipotent cultures. The results show that NKX2.2 expression in these cultures is necessary for survival, proliferation and ability to form neurospheres. Conversely, overexpression of NGN2 led to massive apoptosis, proliferation arrest with formation of neurons, some of which are electrophysiologically active. A different approach would be to target proteins involved in migration to limit the invasive component. Previous studies have shown a key role of DCX in the migration of young neurons during development. The strong expression of DCX in some Gb led me to study the regulation and the role of this gene. In vitro, the results show that DCX is expressed by a subpopulation of cells. Purification of Dcx+ cells and clonal study has shown that they behave as multipotent progenitors with limited self-renewal capacity. I also found that Dcx+ cells can revert back to a Dcx- state and that DCX is regulated by SHH and NOTCH pathways
Walters, Jamie. "Ripples Across The Internet of Things : Context Metrics as Vehicles forRelational Self-Organization." Licentiate thesis, Mittuniversitetet, Institutionen för informationsteknologi och medier, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-14426.
Повний текст джерелаLai, Pengjie. "Improvement of Sigma Voltage Regulator - A New Power Architecture." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/31412.
Повний текст джерелаMaster of Science
Coste, Sandrine. "Evolutions structurale et microstructurale de précurseurs d'oxide de tellure élaborés par voie sol gel." Limoges, 2003. http://aurore.unilim.fr/theses/nxfile/default/4be285e9-7648-43ad-aa46-b68cb7abb725/blobholder:0/2003LIMO0013.pdf.
Повний текст джерелаTellurium based glasses are very promising material for the preparation of optoelectronical devices as they present very high non linear indices. As the classical melting quenching technique is not adapted to the realisation of thin films, we have investigated the sol gel route. Gels are obtained in the tellurium isopropoxide / 2-propanol / acetic acid and tellurium isopropoxide / 2-propanol / citric acid / water systems. During gelification, chemical processes are followed by FTIR and the microstructural evolution is analysed by SAXS. The thermal evolution of the xerogels is characterised by XRD and DSC. The system tellurium isopropoxide / 2-propanol / acetic acid could allow to prepare powders. In the tellurium isopropoxide / 2-propanol / citric acid / water system, the reactivity of the alkoxide is strongly reduced and excellent quality thin films could be obtained
Yu, Oscar Nando. "High Voltage Synchronous Rectifier Design Considerations." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/103384.
Повний текст джерелаDoctor of Philosophy
High voltage power electronics are becoming increasing popular in the electronics industry with the help of wide band-gap semiconductors. While high voltage power electronics research is prevalent, a key component of high voltage power converters, the synchronous rectifier, remains unexplored. Conventional synchronous rectifiers are implemented on high current circuits where diode losses are high. However, high voltage power electronics operate at much lower current levels, necessitating changes in current synchronous rectifier methods. This research aims to identify and tackle issues that will be faced by both systems and IC designers when attempting to implement high voltage synchronous rectifiers on LLC-DCXs. While development takes planes on a LLC-DCX, the research is applicable to most resonant converters and applications utilizing drain-source synchronous rectifier technology. This dissertation focuses primarily on three areas of synchronous rectifier developments: (1) high voltage compatibility; (2) light load effects; (3) accuracy. The first issue opens the gate to high voltage synchronous rectifier research, by allowing high voltage sensing. The second issue explores issues that high voltage synchronous rectifiers can inadvertently influence on the LLC-DCX itself - a light load oscillation issue. The third issue explores novel methods of improving the sensing accuracy to further reduce losses for a single and parallel switch rectifier. In each of these areas, the underlying problem is root-caused, analyzed, and a solution proposed. The overarching goal of this dissertation is to develop a practical, low-cost, universal synchronous rectifier system that can be scaled for commercial use.
Khalaf-Nazzal, Reham. "Caractérisation ultrastructurale, morphologique, et moléculaire des cellules hétérotopiques dans un modèle d'épilepsie hippocampique, chez les souris inactivées pour le gène Dcx." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00831664.
Повний текст джерелаLandeira, Bruna Soares. "Efeitos da elimina??o de neur?nios infragranulares sobre a especifica??o de neur?nios supragranulares do c?rtex cerebral." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17023.
Повний текст джерелаCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
The cerebral cortex of mammals is histologically organized into different layers of excitatory neurons that have distinct patterns of connections with cortical or subcortical targets. During development, these cortical layers are established through an intricate combination of neuronal specification and migration in a radial pattern known as "insideout": deep-layer neurons are generated prior to upper-layer neurons. In the last few decades, several genes encoding transcription factors involved in the sequential specification of neurons destined to different cortical layers have been identified. However, the influence of early-generated neurons in the specification of subsequent neuronal cohorts remains unclear. To investigate this possible influence, we induced the selective death of cortical neurons from layer V and VI before the generation of layer II, III and IV neurons. Thus, we can evaluate the effects of ablation of early born neurons on the phenotype of late born neurons. Our data shows that one-day after ablation, layer VI neurons expressing the transcription factor TBR1 are newly generated while virtually no neuron expressing TBR1 was generated in the same age in control animals. This suggests that progenitors involved in the generation of neurons destined for superficial layers suffer interference from the selective death of neurons in deep layers, changing their specification. We also observed that while TBR1-positive neurons are located exclusively in deep cortical layers of control animals, many TBR1-positive neurons are misplaced in superficial layers of ablated animals, suggesting that the migration of cortical neurons could be controlled independently of neuronal phenotypes. Furthermore, we observed an increase in layer V neurons expressing CTIP2 and neurons expressing SATB2 and that these cells have changed their distributions. As a conclusion, our data indicate the existence of a mechanism of control exercised by the early-generated neurons in the cerebral cortex on the fate of the progenitors involved in the generation of the following cortical neurons. This mechanism could help to control the number of neurons in different layers and contribute to the establishment of different cortical areas
O c?rtex cerebral de mam?feros encontra-se histologicamente organizado em camadas de neur?nios excitat?rios que, por sua vez, apresentam distintos padr?es de conectividade com alvos corticais ou sub-corticais. Durante o desenvolvimento, estas camadas corticais s?o estabelecidas atrav?s de uma intrincada combina??o entre especifica??o neuronal e migra??o radial num padr?o conhecido como "inside-out" (de dentro para fora). Desta forma, por exemplo, neur?nios infragranulares nas camadas V e VI s?o gerados anteriormente aos neur?nios granulares da camada IV, que por sua vez s?o gerados antes dos supra-granulares das camadas II e III. Na ?ltima d?cada, foram identificados diversos genes codificando fatores de transcri??o envolvidos na especifica??o sequencial de neur?nios destinados ?s diferentes camadas corticais. No entanto, ainda pouco ? sabido sobre a influ?ncia dos neur?nios gerados previamente sobre a especifica??o das coortes neuronais subsequentes. Para investigar esta poss?vel influ?ncia, n?s utilizamos um m?todo de recombina??o g?nica (sistema Cre- Lox) para induzir a morte seletiva de neur?nios das camadas corticais V e VI antes da gera??o dos neur?nios das camadas II, III e IV. Dessa forma, pudemos avaliar os efeitos da abla??o de neur?nios infragranulares sobre o fen?tipo dos neur?nios gerados em seguida. Nossos dados mostraram que, um dia ap?s a abla??o, neur?nios da camada VI expressando o fator de transcri??o TBR1 voltaram a ser gerados enquanto praticamente nenhum neur?nio expressando TBR1 foi gerado na mesma idade em animais controle. Esse dado sugere que os progenitores envolvidos na gera??o de neur?nios destinados ?s camadas superficiais sofrem interfer?ncia da morte seletiva de neur?nios de camadas profundas, mudando sua especifica??o. Uma parte dos neur?nios TBR1 se estabeleceu na camada VI e outra migrou at? as camadas II e III, indicando que o controle dos padr?es migrat?rios pode ser independente dos fen?tipos neuronais. Al?m disso, observamos que na popula??o neuronal total tamb?m ocorreu um aumento na quantidade de neur?nios de camada V expressando CTIP2 e uma altera??o na distribui??o dessas c?lulas. O mesmo foi observado para neur?nios supragranulares expressando SATB2. Em conjunto, nossos dados indicam a exist?ncia de um mecanismo de controle exercido pelos neur?nios gerados inicialmente no c?rtex cerebral sobre o destino dos progenitores envolvidos na gera??o dos demais neur?nios corticais. Tal mecanismo poderia contribuir para o controle do n?mero de neur?nios em diferentes camadas e contribuir para o estabelecimento de diferentes ?reas corticais
Zia, Umar. "Enabling Context Awareness in Ambient Environments using Cloud Infrastructures." Thesis, Mittuniversitetet, Institutionen för informationsteknologi och medier, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-15712.
Повний текст джерелаPrasantanakorn, Chanwit. "Current Sharing Method for DC-DC Transformers." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/31112.
Повний текст джерелаMaster of Science
Petit, Ludovic. "Rôles des neurones ectopiques et normotopiques dans la genèse des crises dans les hétérotopies en bandes." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4007.
Повний текст джерелаSubcortical Band Heterotopia (SBH) is a cortical malformation formed when neocortical neurons prematurely stop their migration in the white matter, forming a heterotopic band below the normotopic cortex, and is generally associated with intractable epilepsy. Although it is clear that the band heterotopia and the overlying cortex both contribute to creating an abnormal circuit prone to generate epileptic discharges, it is less understood which part of this circuitry is the most critical. Here, we sought to identify the origin of epileptiform activity in a targeted genetic model of SBH in rats.Rats with SBH were generated by knocking‐down the Dcx gene into neocortical progenitors of rat embryos. Origin, spatial extent and laminar profile of bicuculline‐induced interictal‐like activity on neocortical slices were analyzed by using extracellular recordings from 60‐channels microelectrode arrays. Susceptibility to pentylenetetrazole‐induced seizures was assessed by electrocorticography in head‐restrained nonanaesthetized rats. We show that the band heterotopia does not constitute a primary origin for interictal‐like epileptiform activity in vitro and is dispensable for generating induced seizures in vivo. Further, we report that most interictal‐like discharges originating in the overlying cortex secondarily propagates to the band heterotopia. Importantly, we found that in vivo suppression of neuronal excitability in SBH does not alter the higher propensity of Dcx‐KD rats to display seizures. These results suggest a major role of the normotopic cortex over the band heterotopia in generating interictal epileptiform activity and seizures in brains with SBH
Martineau, Fanny. "Arrêt précoce de la migration neuronale corticale : conséquences cellulaires et comportementales." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0456.
Повний текст джерелаRadial migration is one of the key processes leading to the formation of a six-layered cortex in mammals. Understanding this mechanism is necessary to get a better grasp of cortical development. During my PhD, I studied neuronal migration of pyramidal neurons from two different points of views. The 1st part is related to fundamental biology and assesses how laminar misplacement resulting from migration failure influences neuronal maturation. The 2nd one focuses on pathology by investigating a migration disorder, subcortical band heterotopia, and associated cognitive deficits. For both projects, neuronal migration was impaired in rat through in utero knockdown (KD) of doublecortin (Dcx), a major effector of cortical migration. Misplaced neurons display an abnormal orientation, a simplified dendritic arbor, a decreased spinogenesis and morpho-functional alterations of glutamatergic synaptogenesis. Moreover, our study shows that Dcx plays a role in dendritogenesis, in shaping spine morphology and in fine-tuning glutamatergic synaptogenesis. Finally, we used Dcx-KD rats as an animal model of subcortical band heterotopia to assess how migration failure would impact cortical functions. The behavioral characterization carried out through a wide range of tests did not bring to light any major shortcoming regarding motor, somatosensory or cognitive abilities in these animals. Therefore, although Dcx-KD rats display a SBH and develop spontaneous seizures, it does not seem to recapitulate cognitive deficits found in patients
Tremblay, Marilyn. "DcEx-1 : typologie et distribution spatiale du matériel archéologique historique sur le site de l'ancien poste de traite français de Métabetchouan." Thèse, 2012. http://constellation.uqac.ca/2729/1/030325507.pdf.
Повний текст джерелаDey, Lisa [Verfasser]. "Mutationssuche und deren Analyse in den LIS1- und DCX-Genen bei Patienten mit Lissenzephalie / vorgelegt von Lisa Dey." 2006. http://d-nb.info/981989217/34.
Повний текст джерелаJohnson, Kristin Margaret. "The Relationship Between Adult Hippocampal Neurogenesis and Spatial Learning and Memory in Natural Populations of Food-storing Red Squirrels (Tamiasciurus hudsonicus)." Thesis, 2008. http://hdl.handle.net/1807/17181.
Повний текст джерела