Статті в журналах з теми "Damage-induced orthotropy"

This study proposes analytical and computational methods for the solution of the sliding frictional contact problem of an anisotropic laterally graded layer loaded by an arbitrarily shaped rigid stamp. The plane-strain orthotropy prevails in the layer which is bonded to a rigid foundation. Each of four orthotropic stiffness coefficients is exponentially varied through the lateral direction of the elastic layer. The Fourier transformations of the field variables are employed in the formulation. The gradient of a displacement component on the surface is then converted to a singular integral equation of the second kind. The singular integral equation is solved by means of the Gauss–Jacobi quadrature integration techniques, a collocation method, and a recursive integration method for the Cauchy integral considering the flat and triangular stamp profiles. The finite element method solutions of the same contact problems are performed using the augmented Lagrange method which is implemented in virtue of ANSYS design parametric language. An iterative algorithm is additionally utilized for the (incomplete) triangular stamp problem to conveniently reach the solutions for predetermined contact lengths. The convergence and comparative analyses are carried out to elucidate the trustworthiness of the analytical and computational methods proposed. Moreover, the parametric analyses infer that the contact-induced damage risks can be effectively alleviated upon tuning the degree of orthotropy and the lateral heterogeneity of the elastic layer.

Large scale underground caverns are under construction in high in-situ stress field at Houziyan hydropower station. To investigate deformation and damage of surrounding rock mass, a elastoplastic orthotropic damage model capable of describing induced orthotropic damage and post-peak behavior of hard rock is used, together with a effective approach accounting for the presence of weak planes. Then a displacement based back analysis was conducted by using the measured deformation data from extensometers. The computed displacements are in good agreement with the measured ones at most of measurement points, which confirm the validities of constitutive model and numerical simulation model. The result of simulation shows that damage of surrounding rock mass is mainly dominated by the high in-situ stress rather than the weak planes and heavy damage occur at the cavern shoulders and side walls.

A new micromechanical modelling approach for brittle damage in initially orthotropic materials is presented. The proposed strain-based energy formulation allows to derive a fully anisotropic multilinear model for microcracked materials with arbitrary oriented defects. The thermodynamics framework provides a standard procedure for the damage evolution law. The new model explicitly accounts for the interaction between primary and induced anisotropies. Moreover, the very challenging issue of opening-closure effects (unilateral behavior) is addressed in this framework.

The fatigue life of orthotropic steel decks (OSDs) is significantly affected by vehicle loads, and the local stress response of OSDs is sensitive to the transverse position of vehicle loads. However, the presence of autonomous vehicles is likely to change the transverse distribution of vehicles within the lane, thereby affecting vehicle-induced fatigue damage to OSDs. Therefore, it is necessary to evaluate the potential effect of autonomous vehicles on the fatigue life of OSDs so that appropriate strategies can be implemented to control the transverse positions of autonomous vehicles passing the bridge deck. To this end, fatigue damages of several typical fatigue details in a conventional OSD (COSD) and a lightweight composite OSD (LWCD) induced by vehicle loads were calculated based on finite element analysis, and their fatigue lives were evaluated based on Miner’s Rule, in which different transverse distribution patterns of autonomous vehicles and their proportions in the mixed traffic flow were considered. The results indicate that fatigue lives of both the COSD and the LWCD can be negatively affected by autonomous vehicles traveling across the bridge without any constraints on the transverse distribution, especially when their proportion in the mixed traffic flow exceeds 30%. Compared to the scenario without autonomous vehicles, the fatigue damage of most fatigue details in OSDs may increase by 51% to 210% in the most unfavorable case due to the presence of autonomous vehicles. Nevertheless, it is feasible to extend the fatigue life of OSDs by optimizing the transverse distribution of autonomous vehicles. Specifically, the fatigue life of most fatigue details in the COSD could be extended by more than 86% in the most favorable case when a bimodal Gaussian distribution is adopted as the transverse distribution pattern of autonomous vehicles. Moreover, both the negative and positive effects of autonomous vehicles on the fatigue life of the COSD are more significant than those of the LWCD in most cases. The results can provide references for the maintenance of OSDs under the action of autonomous vehicles.

Transverse cracking is probably the first and most dominant mode of damage in composite materials. In this paper, transverse cracking of cross-ply [02/90n]s (n = 2,3,4) laminates under uniaxial tension load was studied by means of experimental and numerical methods. In the numerical simulations, a simplified computational strategy only focusing on the damage of the resin was proposed and the mechanical response of the cracking cross-ply laminates was studied by finite element analysis of multi-scale representative volume elements (RVEs). In the RVEs, the longitudinal 0° plies were represented by macro-scale, homogeneous, orthotropic elastic solids while the 90° plies were modeled by the discrete fibers and the surrounding matrix resin in micro-scale. Based on researching the critical longitudinal mechanical strain ε x which initiates the cracks, the in-situ transverse ply strength and the stiffness degradation of the transverse plies, the simplified computational strategy proposed was proven correct. In addition, the crack initiation is sensitive to residual stress. Higher process-induced residual stress levels are dangerous to laminates, leading to early crack initiation.

The purpose of this study was to find experimentally the effects of concave and convex major cutting edge (Helical & Recon point) and chisel point on the drilling composite. Due to composite materials are natural orthotropic, so gradually these materials are substituted by some metals such as steel that are used in manufacturing automobile and aerospace and other industris. Because of increasing composites utilization in industries, it is necessary to stabilize and set standards of machining parameters. Drilling is the main machining operation in producing process for assembled the composite work piece. So the quality of drilling hole should be considered to avoid snapping mechanical structure. Tool geometry is one of the most important factors in the drilling process. If it is neglected, the thrust forced increase, and it causes damage around the hole such as delamination, large entrance and exit burr, and induced cracks. The most damaging in drilling FRP is delamination of the composites lamina that occurs when drill bit is entered and exited. In the other hand, this study used ANSYS finite element software to determine the value of stress in composite plate and use to analyze for designing the jig & fixture in this drilling process. In conclusion, with comparing delamination, the best geometry tool introduced for the lowest amount of damage.

The relatively brittle solder/IMC interface fracture process in reflowed solder joints is examined using finite element (FE) method. The interface decohesion is described using a traction-separation quadratic failure criterion along with a mixed-mode displacement formulation for the interface fracture event. Reflowed Sn-4Ag-0.5Cu (SAC405) solder ball on OSP copper pad and orthotropic FR4 substrate under ball shear push test condition at 3000 mm/sec is simulated. Unified inelastic strain constitutive model describes the strain rate-response of the SAC405 solder. Comparable simulated and measured load-displacement values during solder ball shear push test serve as validation of the damage-based FE model. Results indicate a nonlinear damage evolution at each material point of the solder/IMC interface during the ball shear push test. The normal-to-shear traction ratio at the onset of the interface fracture is 1.59 indicating significant induced bending effect due to shear tool clearance. Rapid interface crack propagation is predicted following crack initiation event with the average crack speed up to 24.6 times the applied shear tool speed. The high stress concentration along the edge of the solder/IMC interface facilitates local crack initiation and dictates the shape of the predicted dynamic crack front.

Damage induced localized failure is of vital importance to evaluate residual safety and to prevent catastrophic collapse of concrete structures. Aiming for the efficient and robust modeling of localized failure in quasi-brittle solids and structures, this paper addresses a thermodynamically consistent and numerically efficient localized damage model for concrete. The thermodynamic framework is presented in such a way that not only the continuum model for the bulk material, but also the localized model for the discontinuity, can be established in a consistent approach. For the latter, a localized Helmholtz free energy potential is postulated, mimicking the classical continuum damage model. Specifically, a localized damage variable is introduced to characterize degradation of the initially-rigid discontinuity with a well-defined reference stiffness. Consistent evolution law for the localized damage variable is derived from an appropriate traction-based failure criterion and its equivalent separation-based counterpart, e.g. the novel hyperbolic damage criterion introduced in this work. The proposed model can be regularized and in particular, upon the assumption of continuous stress field, an orthotropic damage model in the context of smeared crack methods is recovered. This coincidence not only justifies the proposed model, but also sheds new lights on other classical methods. Numerically, the proposed localized damage model is incorporated into the improved stable eXtended FEM. Compared to those plasticity-based localized models, an explicit numerical algorithm can be used to update the cohesive tractions transferred across the discontinuity with no iteration on the constitutive level. This feature, together with the well-conditioned system matrix ensured by the improved stable eXtended FEM, guarantees noticeable efficiency and robustness of the overall numerical performances. The proposed model is verified against several classical benchmark tests of concrete in both mode-I and mixed-mode failure. The numerical predictions agree well with experimental test data and those reported in the literature. Remarkably, all the numerical results are mesh-size and mesh-alignment independent, and no spurious stress locking is observed, showing validity of the proposed model in the modeling of localized failure in concrete.

The numerical prediction of impact-induced damage to composite materials and the subsequent residual strength under compression loading continue to be a challenging task. The current study proposes a calibration routine for optimizing the set of material model parameters prior to the virtual simulation of impact tests, which also simplifies the process of parameter determination. The calibration algorithm is based on the comparison of the numerical force-strain or force-displacement curves with the corresponding experimental ones to get the optimal input data, and it includes basic quasi-static material characterization tests. For the sake of simplicity, the calibration process was divided into two parts. The first part includes the in-plane loading tests (tension 0° & 90°, compression 0° & 90°, shear and open-hole tension) for calibration of orthotropic damage material model; whereas the second one consists of the mode I and mode II interlaminar fracture tests as well as the short beam shear test, and it mainly targets to the adjustment of cohesive model parameters. Given the optimal set of parameters of material models, low and high velocity impact simulations at the energy level of 30 J were carried-out to LS-DYNA software and compared with experiments. The percentage difference between numerical and experimental delamination area, after the calibration enablement, reduced from 77% and 60% to 10% and 25% for low- and high-velocity impact, respectively. Afterwards, the damaged specimens were experimentally and virtually tested to compression loading. In terms of maximum compressive load, the computational error is close to 1% for both impact conditions.

The honeycomb (HC) core of sandwich structures undergoes flexural loading and carries the normal compression and shear. The mechanical properties and deformation response of the core need to be established for the design requirements. In this respect, this article describes the development of the smallest possible representative cell (RC) models for quantifying the deformation and failure process of the Nomex polymer-based hexagonal HC core structure under the out-of-plane quasi-static loadings. While the hexagonal single and multi-cell models are suitable for the tension and compression, a six-cell model is the simplest RC model developed for shear in the transverse and ribbon direction. Hashin’s matrix and fiber damage equations are employed in simulating the failure process of the orthotropic cell walls, using the finite element (FE) analysis. The FE-calculated load–displacement curves are validated with the comparable measured responses throughout the loading to failure. The location of the fracture plane of the critical cell wall in the out-of-plane tension case is well predicted. The wrinkling of the cell walls, leading to the structural buckling of the HC core specimen in the compression test, compares well with the observed failure mechanisms. In addition, the observed localized buckling of the cell wall by the induced compressive stress during the out-of-plane shear in both the transverse and ribbon direction is explained. The mesoscale RC models of the polymer hexagonal HC core structure have adequately demonstrated the ability to predict the mechanics of deformation and the mechanisms of failure.

Ultra-high-performance fiber-reinforced cementitious composite (UHPFRC) is used in orthotropic steel deck (OSD) to form a lightweight composite deck structure (LWCD), which is expected to solve the problems of fatigue cracking of traditional steel deck and pavement damage. This paper aims to study the influence of key design parameters on longitudinal bending and transverse fatigue performance, as well as the ultimate bearing capacity calculation theory of the LWCD. A local finite-element (FE) model was built to evaluate the vehicle-induced stress ranges of six typical fatigue-prone details. In total, eight negative bending tests on steel-UHPFRC composite beams and one fatigue test on a steel-UHPFRC composite plate were conducted to investigate the longitudinal bending performance and the transverse flexural fatigue behavior of the LWCD, respectively. The results show that adding a 60-mm UHPFRC layer can significantly reduce the stress amplitude of six typical fatigue details by 44.8% to 90%. The failure mode of the longitudinal bending tests is the U-rib buckle and all UHPFRC layers exhibit multiple cracking behaviors when the specimens failed. The longitudinal cracking stresses of the specimens are between 20.0 MPa to 27.3 MPa. The reinforcement ratio and cover thickness have a great influence on the cracking stress. While the ultimate bearing capacity of specimens with different parameters has little difference. The calculation method of the ultimate bearing capacity of a steel-UHPFRC composite structure is proposed. When the strain at the bottom of the u-rib is taken as 1.2 times the design yield strain, the calculated results are in good agreement with the experimental results. No fatigue failure was observed after 66.12 million fatigue cycles under the design load, highlighting the favorable fatigue resistance of the proposed LWCD.

Stiffness anisotropy is a natural consequence of a fibrous structure of composite materials. The effect of anisotropy can be two-fold: it is highly desirable in some cases to assure a proper material response, while it might be even harmful for the applications based on “isotropic” composite materials. To provide a controllable flexibility in material architecture by corresponding fibre alignment, the methodologies for the precise non-destructive evaluation of elastic anisotropy and the fibre orientation are required. The tasks of monitoring the anisotropy and assessing the fibre fields in composites are analyzed by using the two types of ultrasonic waves suitable for regular plate-shaped composite profiles. In the plate wave approach, the effect of “dispersion of anisotropy” has been shown to make the wave velocity anisotropy to be a function of frequency. As a result, the in-plane velocity pattern measured at a certain frequency is affected by the difference in the wave structure, which activates different elasticity against the background of intrinsic material anisotropy. Phase velocity anisotropy and its frequency dependence provide a frequency variation of the beam steering angle for plate waves (dispersion of beam steering). In strongly anisotropic composite materials, the beam steering effect is shown to provide a strong focusing of ultrasonic energy (phonon focusing). For bulk shear waves, the orthotropic composite anisotropy causes the effect of acoustic birefringence. The birefringent acoustic field provides information on stiffness anisotropy which can be caused by internal stresses, texture, molecular or/and fibre orientation. On this basis, a simple experimental technique is developed and applied for mapping of fibre orientation in composite materials. Various modes of acoustic birefringence are analyzed and applied to assessing the fibre fields in injection moulding composites and to identify the fibre lay-ups in multiply materials. The birefringence pattern is also shown to be sensitive and applicable to characterizing impact- and mechanical stress-induced damage in composites.

Cancer initiating cells (CIC) are suggested to be responsible for drug resistance and cancer relapse that are associated with poor prognosis. Therefore, drugs effective for CIC could fulfill an unmet clinical need. We performed a drug screen with chemical libraries to find out new compounds which specifically eradicated CIC established in the previous report (Yamashita et al., Cancer Research, 2015). We obtained compounds with a carboxylic acid skeleton as hit compounds. Interestingly, FF1215T, one of the hit compounds, was shown to inhibit growths of CIC by decreasing intracellular pyrimidine nucleotide levels. Finally, we identified dihydroorotate dehydrogenase (DHODH), which was essential for de novo pyrimidine synthesis as the target of the hit compounds in a ligand fishing assay. FF1215T inhibited DHODH enzymatic activity with the 50% inhibitory concentration value of 9 nM, which showed greater potency than well-known DHODH inhibitors brequinar (12 nM), teriflunomide (262 nM), and vidofludimus (141 nM). Growing evidence suggests that DHODH is considered to be a promising target to overcome a differentiation blockade of acute myeloid leukemia (AML) cells (Sykes et al., Cell, 2016).Therefore, we explored the effect of FF1215T on AML growth and differentiation. FF1215T demonstrated growth inhibitory effect in multiple human AML cell lines such as U937, MOLM13, HL60, and MV4-11 with the 50% growth inhibition values of 90-170 nM. FF1215T decreased intracellular pyrimidine nucleotide levels, induced DNA damage marker γ-H2AX possibly due to the replication stress, and finally led to apoptosis in HL60 cells. Cell cycle analysis revealed that FF1215T treatment arrested HL60 and THP1 cells at S phase and increased sub-G1 population in these cells. In addition, our DHODH inhibitors induced upregulation of cell-surface CD11b and CD86, which are monocyte and macrophage differentiation markers, morphological changes, and phagocytic activities in several AML cells, indicating differentiation of AML cells toward monocyte and macrophage by DHODH inhibition. FF1215T also depleted UDP-GlcNAc, a substrate for Protein O-GlcNAcylation, and diminished global O-GlcNAcylation and O-GlcNAcylated protein expressions such as c-Myc, SOX2, and OCT4, which play important roles in maintenance and self renewal of stem cells. We also found that our DHODH inhibitors induced CD11b and CD86, and increased the ratio of macrophage-like cells in primary patient-derived AML cells and these effects were rescued by uridine supplementation (Fig). Inhibitions of colony formations of primary AML cells were also shown after 14 days of FF1215T treatment. In exploring the value of DHODH inhibitors in the clinic, we identified that our DHODH inhibitors worked to overcome the resistance of standard therapy Ara-C. Our DHODH inhibitors were effective against Ara-C-resistant models of HL60 cells as well as HL60 parental cells. Notably, our DHODH inhibitors synergistically inhibited growths of Ara-C-resistant THP1 cells and enhanced CD11b upregulation of THP1 cells when combined with Ara-C by activating conversion of Ara-C to its active form Ara-CTP. Next, we optimized the hit compounds and identified an orally available DHODH inhibitor FF14984T that achieved high and prolonged plasma concentrations in vivo. Oral administration of 10 and 30 mg/kg FF14984T once daily for 10 days exhibited significant anti-tumor effects in mice xenografted with HL60 cells. These treatments showed strong reduction of CTP in tumor and induction of DHO in tumor and plasma. When 30 mg/kg FF14984T was orally administrated to orthotropic MOLM13-xenografted mice once daily for 12 days, hCD45+ cells proportions in bone marrow were decreased whereas hCD11bhigh/hCD45+ ratio increased, indicating that FF14984T induced AML differentiation in vivo. Finally, oral administration of 30 mg/kg FF14984T once daily significantly prolonged survival of mice in U937 orthotropic models. Taken together, we developed a novel potent DHODH inhibitor FF14984T that induced cellular differentiation and anti-leukemic effects on cell lines and primary AML cells. FF14984T is possibly a promising therapeutic option for Ara-C-resistant AML patients that can also benefit from the combination therapy of FF14984T and Ara-C. Identifying the precise mechanism of AML differentiation by DHODH inhibitor and its effects on CIC are currently ongoing. Disclosures Kitazawa: FUJIFILM Corporation: Employment. Ishii:FUJIFILM Corporation: Employment. Makita-Suzuki:FUJIFILM Corporation: Employment. Saito:FUJIFILM Corporation: Employment. Takayanagi:FUJIFILM Corporation: Employment. Sugihara:FUJIFILM Corporation: Employment. Matsuda:FUJIFILM Corporation: Employment. Yamakawa:FUJIFILM Corporation: Employment. Tsutsui:FUJIFILM Corporation: Employment. Tanaka:FUJIFILM Corporation: Employment. Hatta:FUJIFILM Corporation: Research Funding. Natsume:FUJIFILM Corporation: Research Funding. Kondo:FUJIFILM Corporation: Research Funding. Hagiwara:FUJIFILM Coporation: Employment. Kiyoi:FUJIFILM Corporation: Research Funding; Astellas Pharma Inc.: Honoraria, Research Funding; Chugai Pharmaceutical Co., Ltd.: Research Funding; Kyowa Hakko Kirin Co., Ltd.: Research Funding; Zenyaku Kogyo Co., Ltd.: Research Funding; Bristol-Myers Squibb: Research Funding; Daiichi Sankyo Co., Ltd: Research Funding; Sumitomo Dainippon Pharma Co., Ltd.: Research Funding; Nippon Shinyaku Co., Ltd.: Research Funding; Otsuka Pharmaceutical Co.,Ltd.: Research Funding; Eisai Co., Ltd.: Research Funding; Takeda Pharmaceutical Co., Ltd.: Research Funding; Pfizer Japan Inc.: Honoraria; Perseus Proteomics Inc.: Research Funding.

AbstractIn this article we explore the change in elastic symmetry and anisotropy of two geological materials with stress-induced damage. Two independent uniaxial deformation experiments on two layered and natural geomaterials, a shale and a sandstone, support this analysis. Both samples were loaded along their bedding planes at a constant strain rate up to mechanical failure. During deformation, an array of ultrasonic P- and S-wave transducers were employed to monitor the evolution of the ultrasonic velocities up to and beyond sample failure. We report here the impact on elastic symmetry and anisotropy of a uniaxial load applied parallel to the bedding plane of the transversely isotropic shale and sandstone samples. Based on symmetry considerations we analyse whether this load and the resulting stress-induced damage preserve the original transverse isotropy of the rock prior to loading, or lead to orthotropy (orthorhombic symmetry). Our results show that the two transverse isotropic samples retained their transverse isotropy in the initial stages of loading/damage. However for the more anisotropic shale sample the main failure mode was splitting of the bedding planes. In contrast the sandstone sample failed along a shear plane inclined to the bedding plane. In addition, the experimental data are further analysed using continuum damage mechanics to identify the evolution of the general fourth order anisotropic damage tensor during loading. We found that the highest damage variable of the damage tensor was $$D_{11}$$ D 11 for the shale and $$D_{55}$$ D 55 for the sandstone sample. The next highest damage variables for the shale sample were related to the bedding plane ($$x_2$$ x 2 –$$x_3$$ x 3 plane) symmetry: $$D_{23}, D_{32}, D_{44}$$ D 23 , D 32 , D 44 . However the damage variables obtained for the less anisotropic and more brittle sandstone sample were harder to interpret due to the mixed mode of fracturing present.

Despite the superior properties of ceramic matrix composites (CMCs), their fabrication process generates inevitable defects with high density that significantly influence material integrity and residual useful life. Recent efforts have focused on CMC property prediction and investigation of their different inelastic mechanisms, but very limited work exists on understanding the influence of defects on inelastic responses of CMCs. Here, we introduce a three-dimensional micromechanics computational framework that includes experimentally informed material microstructure and architectural variabilities to investigate CMC response in the presence of manufacturing-induced defects. A developed microstructure generation algorithm is used to generate the representative volume elements in the micromechanics models from complex material morphology information obtained from extensive characterization studies of C/SiNC and SiC/SiNC CMCs. A fracture mechanics-informed matrix damage model is reformulated, in which the model considers the growth of porosity and microcracks in the as-received material. A progressive fiber damage model as well as Orthotropic viscoplasticity creep formulation are also utilized for the study. This methodology is implemented within the micromechanics framework to investigate the complex temperature- and time-dependent load transfer and damage mechanisms of CMCs under operation loading conditions. The developed framework explores the influence of as-received defects on the damage and creep behavior in service conditions. It also provides new insights into the effect of size, shape, distribution, and location of these defects on material response. The framework is then calibrated with unidirectional CMC minicomposite results available in the literature.