Дисертації з теми "Cyclosporin"
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Husi, Holger. "Cyclosporins and cyclosporin binding proteins : an insight into the mechanism of immunosuppression /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10937.
Повний текст джерелаJames, Jacqueline A. "Cyclosporin A and gingival overgrowth." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282191.
Повний текст джерелаFrench, Martin Thomas. "Fluorescence immunoassay for cyclosporin A." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/33279.
Повний текст джерелаGerber, Andreas. "Totalsynthese von Cyclosporin A an der Festphase /." [S.l.] : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8755.
Повний текст джерелаMereish, Kulthoum A. "Alteration of cyclosporin : a bioavailability through complexation /." Ann Arbor : University Microfilms International, 1985. http://www.gbv.de/dms/bs/toc/01641747x.pdf.
Повний текст джерелаDavid, Oliver Jean Claude. "New approaches to improve cyclosporin A monitoring." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395488.
Повний текст джерелаHutchison, Stephen Michael William. "Studies in cyclosporin nephrotoxicity in the rat." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335321.
Повний текст джерелаPowles, A. V. "Cyclosporin for psoriasis : clinical and immunopathological studies." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253658.
Повний текст джерелаSpitzfaden, Claus. "Strukturbestimmung des Cyclophilin/Cyclosporin-Komplexes mittels NMR-Spektroskopie /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10406.
Повний текст джерелаGillam, Elizabeth Maree Jeffery. "The interaction of cyclosporin A with cytochromes P450." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280968.
Повний текст джерелаWastling, Jonathan Mark. "The action of cyclosporin A on helminth parasites." Thesis, University of Aberdeen, 1990. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU031936.
Повний текст джерелаKhan, Lillian Nasreen. "Effect of cyclosporin A on the immunopathology of asthma." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409081.
Повний текст джерелаAldridge, R. D. "Modulation of delayed-type hypersensitivity reactions by cyclosporin A." Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234482.
Повний текст джерелаGudgeon, M. C. "Studies on the mechanism of action of cyclosporin A." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378279.
Повний текст джерелаDiehl, Rita. "Verträglichkeit und Effektivität Cyclosporin A-vermittelter Immunsuppression beim Schaf für die xenogene, intrazerebrale Transplantation." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-214365.
Повний текст джерелаRiether, Carsten. "Peripheral mediatory mechanisms of behaviorally conditioned immunosuppression by cyclosporin A /." [S.l.] : [s.n.], 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18085.
Повний текст джерелаZhang, Yixin. "Rational design of cyclosporin A derivatives for selective enzyme inhibition." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964279401.
Повний текст джерелаOrmrod, Douglas James. "Modulation of non-specific cellular defence mechanisms by cyclosporin A." Thesis, University of Auckland, 1990. http://hdl.handle.net/2292/3195.
Повний текст джерелаWang, Su. "Transdermal delivery of cyclosporin A by electrically enhanced permeation techniques." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq23183.pdf.
Повний текст джерелаMisseghers, Byron S. "The histologic characterization of perianal fistulas during treatment with cyclosporin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/NQ47400.pdf.
Повний текст джерелаKONDO, TATSUHEI, HIROSHI TAKAGI, and TAKESHI MORIMOTO. "Canine Pancreatic Allotransplantation with Duodenum (Pancreaticoduodenal Transplantation) Using Cyclosporin A." Nagoya University School of Medicine, 1985. http://hdl.handle.net/2237/17478.
Повний текст джерелаBaumgart, Alessandra. "Cyclosporin A und dessen möglicher Einsatz bei der Tigerschecken-Uveitis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168992.
Повний текст джерелаMcNally, P. G. "The influence of calcium channel blockers on cyclosporin A nephrotoxicity." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/34162.
Повний текст джерелаWang, Su. "Transdermal delivery of cyclosporin B by electrically enhanced permeation techniques /." St. John's, NF : [s.n.], 1997.
Знайти повний текст джерелаRichter, Sebastian. "Rapamycin vs. Cyclosporin A : Auswirkungen auf Transplantatabstossung und Tumorwachstum im Tiermodell." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1352/.
Повний текст джерелаBäuerle, Alexander Lutz [Verfasser]. "Die Therapie der membranösen Glomerulonephritis mit Cyclosporin A / Alexander Lutz Bäuerle." Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1028033567/34.
Повний текст джерелаMcLauchlan, P. E. "Host-parasite interactions : cellular immune responses and modulation by cyclosporin A." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593084.
Повний текст джерелаMyrillas, Theofilos T. "Cellular mechanisms underlying the pathogenesis of cyclosporin A-induced gingival overgrowth." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284391.
Повний текст джерелаChan, Weng C. "A study of the medicinal chemistry related to the C9-ene amino acid of cyclosporin." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381104.
Повний текст джерелаGennai, Stéphane. "Effets de la cyclosporine A sur des poumons porcins reperfusés ex vivo." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENS012/document.
Повний текст джерелаObjective Several works highlighted the role of Cyclosporine A (CsA) in the prevention of ischemia reperfusion (I/R) injuries but none on isolated lungs of big mammals. Our objective was to measure for the first time the effects of CsA in I/R injuries in an ex vivo reperfused pig lungs model, by evaluating several doses of CsA for different times of ischemia. Methods Experimentation A was performed on 4 groups of 8 pairs of lungs each: a control group and 3 groups receiving different concentrations of CsA (1, 10 or 30 μM) at the time of ischemia and at the beginning of the reperfusion, after a 2 hours ischemia. Experimentation B was performed on 3 groups of 5 pairs of lungs each. Lungs from each pair were separated just after the beginning of ischemia. The first lungs were evaluated after a 2 hours ischemia (day 0), without CsA. The second lungs were evaluated after a 24 hours ischemia (day 1), either without or with CsA (1 or 5 μM), administered when appropriate at the beginning of the reperfusion. Results CsA improved the PO2/FiO2 ratio with a dose dependent effect but increased pulmonary arterial pressure, capillary pressure, and pulmonary vascular resistances, at 10 and 30 μM but neither at 1 or 5 μM. Lungs receiving 30 μM of CsA displayed elevated concentrations in pro-inflammatory cytokines. Concentrations in RAGE (receptor for advanced glycation endproducts) in broncho-alveolar lavage decreased with CsA at day 1 compared to day 0. Conclusions During pulmonary I/R, the cellular benefits of high doses of CsA are counterbalanced by its hemodynamic effects on microvascularisation. At low doses, CsA seems to improve lung function
Saunders, R. N. "The effect of rapamycin after cyclosporin dose reduction on chronic allograft nephropathy." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29442.
Повний текст джерелаHorrocks, C. "Immunological studies into the mechanisms of action of cyclosporin A in psoriasis." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592590.
Повний текст джерелаHeys, Stephen D. "The potentiation and alleviation of cyclosporin A nephrotoxicity in the Lewis rat." Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254668.
Повний текст джерелаTakayama, Akira. "Transport of cyclosporin A in kidney epithelial cell line (LLC-PK[1])." Kyoto University, 1995. http://hdl.handle.net/2433/160728.
Повний текст джерелаKyoto University (京都大学)
0048
新制・論文博士
博士(医学)
乙第8919号
論医博第1514号
新制||医||613(附属図書館)
UT51-95-P410
(主査)教授 藤田 潤, 教授 吉田 修, 教授 乾 賢一
学位規則第4条第2項該当
Cunningham, Charles. "Aspects of the relationship between the metabolism and toxicity of cyclosporin A." Thesis, University of Aberdeen, 1985. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU356459.
Повний текст джерелаSieber, Matthias. "Modulatoren des Calcineurin-NFATc-Signalweges in humanen TH-Zellen." Phd thesis, Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4467/.
Повний текст джерелаThe Ca2+/calmodulin dependent serine/threonine phosphatase calcineurin is a key molecule in the T cell receptor dependent signalling network. Calcineurin dephosphorylates and thereby activates the transcription factors of the NFATc family that, among others, control the expression of important cytokines and cell surface molecules. The activity of Calcineurin is modulated by several endogenous proteins and is inhibited by the immunosuppressants cyclosporine A and FK506. Here, the novel low molecular weight inhibitor NCI3 was characterized in respect to its effects on T cell receptor dependent signalling. The results of this work show, that the pyrazolopyrimidine derivate NCI3 is nontoxic and permeates the cell membrane. Upon TCR stimulation NCI3 suppresses T cell proliferation and IL-2 production of primary human TH cells with IC50 values of ~4 µM by blocking the dephosphorylation and subsequent nuclear translocation of NFATc. NCI3 conse-quently inhibits calcineurin dependent NFAT- and NF-κB-, but not AP-1-controlled reporter gene expression, in micromolar concentrations (IC50 values 2 and 7 µM, respectively). In opposite to cyclosporine A and FK506, NCI3 does not interfere with the phosphatase activity of calcineurin but rather disturbs the calcineurin-NFATc interaction. A major endogenous modulator of calcineurin is the protein RCAN1, which is supposed to regulate calcineurin-NFATc signalling in a negative feedback loop. The presented data show that RCAN1 is expressed in human TH cells. The splice variant RCAN1-1 is basally expressed in resting T cells, and its expression levels are not changed by T cell receptor stimulation. Expression of RCAN1-4, on the other hand, is nearly undetectable in resting TH cells and is induced upon cell stimulation. By using calcineurin-NFATc specific inhibitors such as NCI3 it could be shown that RCAN1-4 induction is limited by this pathway. This work provides a comprehensive characterization of the novel inhibitor NCI3 and insights into the regulation of calcineurin by RCAN1 in human TH cells.
Sedighiani, Fazilat. "Tacrolimus vs. Cyclosporin als primäre immunsuppressive Therapie bei akuten rezidivierenden Abstoßungsreaktionen nach Herztransplantation." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-60184.
Повний текст джерелаMarlowe, Sharon Nalini Singh. "Azathioprine and cyclosporin A as second line treatments for severe leprosy type reactions." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424945.
Повний текст джерелаCheah, Su-Yin. "Methotrexate, cyclosporin and sulfasalazine in the treatment of rheumatoid arthritis : a systematic review." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285683.
Повний текст джерелаGerlach, Thomas [Verfasser], Markus [Akademischer Betreuer] Neurath, and Benno [Akademischer Betreuer] Weigmann. "Molekulare Analyse des Immunsuppressivums Cyclosporin A / Thomas Gerlach. Gutachter: Markus Neurath ; Benno Weigmann." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1075840473/34.
Повний текст джерелаFischer, Ricardo Guimaräes. "The ferret in periodontal research clinical features, histology, microbiology and immunosuppression (Cyclosporin-A) /." Malmö : Dept. of Periodontology, Center for Oral Health Sciences, Lund University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/28161627.html.
Повний текст джерелаMITSUYAMA, Hirohito, Fukushi KAMBE, Ryuichiro MURAKAMI, Naoki ISHIGURO, and Hisao SEO. "Analysis of Interieukin-8 Gene Promoter function in Human Osteoblast-like Cells : Regulation by Ca^<2+>-signaling and Cyclosporin A." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2782.
Повний текст джерелаÖstraat, Öyvind. "Experimental modulation and suppression of anti-allograft immune response." Malmö : Dept. of Surgery, Lund University, Malmö University Hospital, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38950482.html.
Повний текст джерелаMangels, Corinna. "Unerwünschte Arzneimittelwirkungen bei der Anwendung von Cyclosporin A (Atopica®) bei Hund und Katze." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-147364.
Повний текст джерелаHodgkinson, Brent C. "The effect of cyclosporin A (CsA) on antioxidant status in the male Wistar rat." Thesis, University of Ottawa (Canada), 2000. http://hdl.handle.net/10393/9042.
Повний текст джерелаEchtler, Silvia. "Einfluss einer auf Cyclosporin A basierenden immunsuppressiven Therapie auf den Knochenmineralstoffwechsel nach orthotoper Herztransplantation." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-172602.
Повний текст джерелаCusack, Rodney Michael. "An investigation of the interaction of metal ions with cyclic octapeptides and cyclosporin A /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16238.pdf.
Повний текст джерелаPassoth, Peter René. "Das Auftreten einer neurodermitisähnlichen Dermatitis bei Kindern nach Herztransplantation im ersten Lebensjahr unter Cyclosporin A." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965520749.
Повний текст джерелаMalinowski, Michael. "Systemisches Mycophenolatmofetil versus Cyclosporin A nach perforierender Hochrisiko-Keratoplastik Ergebnisse einer randomisierten, prospektiven klinischen Studie /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967644240.
Повний текст джерелаKAMBE, Fukushi, Hisao SEO, and Xia CAO. "Cyclosporin A (CsA)-sensitive Pathway for the Induction of ZAKI-4 Expression by Thyroid Hormone." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2778.
Повний текст джерела