Готові списки джерел за темами / Cyclodextrin Molecules

Добірка наукової літератури з теми "Cyclodextrin Molecules"

Автор: Grafiati
Опубліковано: 18 травня 2024

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Зміст

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Cyclodextrin Molecules".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "Cyclodextrin Molecules"

1

Cardoso, T., C. I. C. Galhano, M. F. Ferreira Marques та A. Moreira da Silva. "Thymoquinoneβ-Cyclodextrin Nanoparticles System: A Preliminary Study". Spectroscopy: An International Journal 27 (2012): 329–36. http://dx.doi.org/10.1155/2012/902486.

Повний текст джерела
Анотація:
Thymoquinone is a natural product, the main constituent ofNigella sativaseeds, which exhibits anti-inflammatory and anticancer activities. Among several existing molecules capable of forming an inclusion compound structure, cyclodextrins are applied in the pharmaceutical industry either to increase solubility of hydrophobic molecules or to protect molecules from inactivation or degradation.β-Cyclodextrin is currently the most common cyclodextrin in pharmaceutical formulations and probably the best studied in humans. In order to study the properties of inclusion compounds based on cyclodextrins and thymoquinone Fourier Transform Infrared (FTIR), Ultraviolet-Visible, Positron Annihilation Lifetime (PAL) Spectroscopies and calorimetric studies by Differential Scanning Calorimetry (DSC) were used. The obtained results indicate the formation of a 1 : 1 inclusion compound between cyclodextrin and thymoquinone. PALS and DSC measurements also provided evidence of the inclusion compound's activity.
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Pereva, Stiliyana, Valya Nikolova, Silvia Angelova, Tony Spassov та Todor Dudev. "Water inside β-cyclodextrin cavity: amount, stability and mechanism of binding". Beilstein Journal of Organic Chemistry 15 (17 липня 2019): 1592–600. http://dx.doi.org/10.3762/bjoc.15.163.

Повний текст джерела
Анотація:
Cyclodextrins (CDs) are native host systems with inherent ability to form inclusion complexes with various molecular entities, mostly hydrophobic substances. Host cyclodextrins are accommodative to water molecules as well and contain water in the native state. For β-cyclodextrin (β-CD), there is no consensus regarding the number of bound water molecules and the location of their coordination. A number of intriguing questions remain: (1) Which localities of the host’s macrocycle are the strongest attractors for the guest water molecules? (2) What are the stabilizing factors for the water clusters in the interior of β-CD and what type of interactions between water molecules and cavity walls or between the water molecules themselves are dominating the energetics of the β-CD hydration? (3) What is the maximum number of water molecules inside the cavity of β-CD? (4) How do the thermodynamic characteristics of β-CD hydration compare with those of its smaller α-cyclodextrin (α-CD) counterpart? In this study, we address these questions by employing a combination of experimental (DSC/TG) and theoretical (DFT) approaches.
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Brown, SE, JH Coates, CJ Easton, SF Lincoln, Y. Luo, and AKW Stephens. "Cyclodextrin Inclusion Complexes of Two Non-Steroidal Antiinflammatory Drugs and of an Analgesic Drug." Australian Journal of Chemistry 44, no. 6 (1991): 855. http://dx.doi.org/10.1071/ch9910855.

Повний текст джерела
Анотація:
U.v .-visible spectrophotometric studies of the interactions of Naproxen, Ibuprofen and Panadol with α-cyclodextrin , β-cyclodextrin, γ-cyclodextrin and dimethyl β- cyclodextrin enable the determination of stability constants of inclusion complexes when their formation gives rise to appreciable spectral changes. The magnitudes of the stability constants are discussed in terms of the relative sizes and the chemical natures of the cyclodextrins and the included molecules.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Belyakova, L. A., A. M. Varvarin, D. Yu Lyashenko, and O. V. Khora. "Designing Adsorption Centres for Biological Active Molecules on a Silica Surface." Adsorption Science & Technology 23, no. 9 (November 2005): 703–19. http://dx.doi.org/10.1260/026361705776316596.

Повний текст джерела
Анотація:
The chemical interaction between the surface of hydroxylated or aminated silicas and β-cyclodextrin, mono-tosyl-β-cyclodextrin and the bromine derivative of heptakis-[6- O-( p-tosyl-β-cyclodextrin)] has been investigated using IR spectroscopy, thermogravimetric analysis with programmed heating, pH titration, weight adsorption method, elemental analysis and quantitative chemical analysis of the surface compounds. The optimum conditions for chemical grafting of β-cyclodextrins onto the silica surface were established. The formation of supramolecular structures, viz. inclusion complexes between immobilized β-cyclodextrin and the hormone of pineal gland (melatonin), on the surface of highly dispersed silicas of 1:1 composition was demonstrated.
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Wang, Runmiao, Hui Zhou, Shirley W. I. Siu, Yong Gan, Yitao Wang, and Defang Ouyang. "Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation." Journal of Nanomaterials 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/193049.

Повний текст джерела
Анотація:
Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. Ibuprofen was used as a model drug. Binding free energy from three simulation methods was calculated as an important parameter to compare with the experimental results. Docking results from AutoDock Vina program showed that the scoring of complexation capability between ibuprofen and cyclodextrins is alpha (α), gamma (γ), beta (β), and HP-beta-cyclodextrins, which indicated similar ranking with the results from phase, solubility diagram experiments. MD simulation indicated that ibuprofen could form the stable complexes withβ-,γ-, and HP-β-cyclodextrins, but not for alpha cyclodextrin. Binding free energies from the MD simulation forβ-,γ-, and HP-β-cyclodextrins were −3.67, −0.67, and −3.87 kcal/mol, individually. The enthalpies of QM simulation forβ-,γ-, and HP-β-cyclodextrins were −17.22, −14.75, and −20.28 kcal/mol, respectively. Results from all three modeling approaches showed similar ranking between ibuprofen and four cyclodextrin molecules as the experimental data. However, MD simulation with entropy calculation had the closest value to experimental data forβand HP-beta-cyclodextrins. Thus, MD simulation with MM-PBSA method may be fit toin silicoscreen for cyclodextrin formulations.
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Székely-Szentmiklósi, Blanka, and B. Tőkés. "Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis." Acta Medica Marisiensis 59, no. 2 (April 1, 2013): 107–10. http://dx.doi.org/10.2478/amma-2013-0026.

Повний текст джерела
Анотація:
AbstractIntroduction: In the present work we evaluated the complexation role of cyclodextrins toward fluoroquinolones in an attempt to assess their potential as new formulation additives for more efficient fluoroquinolone delivery and as selectors in capillary electrophoresis.Material and method: Guest-host interactions of two second generation quinolones, ciprofloxacin and norfloxacin with four cyclodextrins, beta-cyclodextrin (β-CD), gamma-cyclodextrin (γ-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and randomly methylated beta-cyclodextrin (RAMEB), were tested by capillary electrophoresis in borate running buffer. Experimental parameters like buffer concentration, pH, organic modifier, voltage and cyclodextrin concentration have been varied for a better resolution.Results: In capillary zone electrophoresis ciprofloxacin and norfloxacin are migrating together, a difference in their migration times and thus separation occured by the addition of cyclodextrins.Conclusion: Our results suggest formation of inclusion complexes between fluoroquinolones and cyclodextrins. Differences in their affinity to host molecules resulted in separation of the two fluoroquinolones
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Sivakumar, Ponnurengam M., Shohreh Peimanfard, Ali Zarrabi, Arezoo Khosravi, and Matin Islami. "Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy." Anti-Cancer Agents in Medicinal Chemistry 20, no. 11 (July 8, 2020): 1327–39. http://dx.doi.org/10.2174/1871520619666190906160359.

Повний текст джерела
Анотація:
Background and Objective: Cyclodextrins have been of great interest as excellent candidates for fabricating versatile nano-drug delivery systems due to their commercial availability, easy functionalization, low immunogenicity, biocompatibility and safety. The possibility of reversible inclusion complex formation between cyclodextrins and various guest molecules in association with versatile exclusive properties of cyclodextrins offer a route towards the fabrication of highly sophisticated nanostructures with enormous potential for cancer treatment. Methods and Results: The current review discusses important recent advances in the fabrication and development of cyclodextrin-based nanostructures for cancer therapy. Firstly, the formation of inclusion complexes between cyclodextrin derivatives and anticancer compounds, as well as their application, are summarized. Secondly, the cyclodextrins -based nanosystems including cyclodextrin-containing polymers, cyclodextrin-based supramolecular necklaces, which consist of polyrotaxanes and polypseudorotaxanes and cyclodextrin based hydrogels accompanied by their applications in cancer treatment are highlighted. In the end, the future perspective of this field is discussed. Conclusion: Numerous investigations in this area pave the way for the flourishing of the next generation of nano-therapeutics towards enhanced cancer therapy.
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Belyakova, L. A. "Encapsulation of benzene carboxylic acids using cyclodextrins." Himia, Fizika ta Tehnologia Poverhni 12, no. 1 (March 30, 2021): 40–51. http://dx.doi.org/10.15407/hftp12.01.040.

Повний текст джерела
Анотація:
The encapsulation of medicinal substances in various polymers is a common way to increase their thermal, hydrolytic, and chemical stability. However, the bioavailability of the encapsulated drugs decreases. The solution to this important problem can be the preparation of nanocapsules of medicinal substances using complexing agents, for example, cyclodextrins. The purpose of this work is to study the possibility of encapsulation of benzoic, salicylic, and β-resorcylic acids using α- and β-cyclodextrins. The interaction of benzene carboxylic acids with cyclodextrins in aqueous solutions at 20–30 оС has been studied by spectrophotometry. The formation of complexes with a composition of 1:1 in the cyclodextrin – benzene carboxylic acid systems has been proven. The stability constants of the complexes and the main thermodynamic parameters of complex formation have been calculated. It has been shown that the nature of changes in the spectral characteristics of benzene carboxylic acids in the presence of cyclodextrins can be used to predict the possibility of aromatic organic compounds encapsulation. The determining role of the complementarity of geometric parameters of cyclodextrins and benzene carboxylic acids in the preparation of inclusion complexes with features of nanocapsules has been found. The prospects of using β-cyclodextrin for encapsulation of benzene carboxylic acids have been demonstrated. The complexes of β-cyclodextrin with benzene carboxylic acids were synthesized and studied by IR spectroscopy, X-ray analysis and derivatography. The formation of two types of complexes in the β-cyclodextrin – benzene carboxylic acid system was established. The first type of complexes is formed due to nonspecific interactions between the hydrophobic cavity of β-cyclodextrin and the benzene carboxylic acid molecule, the second type is due to specific interactions between the functional groups of molecules. Benzoic and salicylic acids form nanocapsules with β-cyclodextrin, and their hydrolytic and thermal stability increases. Complexes of the second type acquire the properties of a new compound: β-resorcylic acid loses its individuality, forming strong supramolecular structures with β-cyclodextrin.
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Welliver, Mark, and John P. McDonough. "Anesthetic Related Advances with Cyclodextrins." Scientific World JOURNAL 7 (2007): 364–71. http://dx.doi.org/10.1100/tsw.2007.83.

Повний текст джерела
Анотація:
Cyclodextrins encapsulate and electrostatically bind to lipophilic molecules. The exterior of cyclodextrins are water-soluble and maintain aqueous solubility despite encapsulation of non-aqueous soluble molecules. This unique ability to encapsulate lipophilic molecules and maintain water solubility confers numerous pharmacologic advantages for both drug delivery and removal. Cyclodextrins, a component part of supramolecular chemistry, may be in its infancy of anesthetic application but recent advances have been described as novel and revolutionary. A review of current research coupled with an understanding of cyclodextrin properties is necessary to fully appreciate the current uses and future potentials of these unique molecules.
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Braga, Susana Santos. "Cyclodextrins as Multi-Functional Ingredients in Dentistry." Pharmaceutics 15, no. 9 (August 31, 2023): 2251. http://dx.doi.org/10.3390/pharmaceutics15092251.

Повний текст джерела
Анотація:
Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Their role in each of the innovative materials is presented. Finally, the prospect of the use of cyclodextrin-based delivery systems for the oral cavity is introduced, with a focus on new cyclodextrin molecules with dual action as bone-targeting agents and osteogenic drugs, and on new cross-linked cyclodextrin particles with a high drug loading and sustained drug delivery profile for the treatment of diseases that require prolonged action, such as periodontitis. In conclusion, cyclodextrins are herein demonstrated to act as versatile and multi-action ingredients with a broad range of applications in dentistry.
Стилі APA, Harvard, Vancouver, ISO та ін.
Більше джерел

Дисертації з теми "Cyclodextrin Molecules"

1

Huang, Tian He. "Investigation of cyclodextrin formulations by combined experimental and molecular modeling techniques." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952153.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Binti, Mohtar Noratiqah. "Cyclodextrin-based formulations for pulmonary delivery of chemotherapeutic molecules." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10054726/.

Повний текст джерела
Анотація:
This study investigated cyclodextrin-based formulations for the delivery of fisetin (a flavonoid) and erlotinib (a tyrosine kinase inhibitor) to the lung. In the first part of the study, complexation of fisetin with β-cyclodextrin (β-CD) and its derivatives, namely hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD), was conducted. Complexation efficiency between fisetin and the cyclodextrins was in the order: SBE-β-CD > HP-β-CD > β-CD. Utilisation of 20%v/v ethanol during complexation with SBE-β-CD improved the solubilisation of fisetin 5.9-fold compared to using water alone. Spray-drying of the fisetin-SBE-β-CD complex from 20%v/v ethanol feed solution, produced a powder with a 2-fold increase in the fine particle fraction (FPF) compared to the spray-dried powder produced from a feed solution containing water alone, when characterised using the Next Generation Impactor (NGI). Addition of 20%w/w leucine into the powder produced from the ethanolic feed solution further improved the FPF by 2.3-fold compared to the powder without leucine. The preparation showed an unchanged cytotoxic activity of fisetin against the human lung adenocarcinoma (A549) cell line, when compared to fisetin solution. In the second part of the study, combinations of fisetin with three tyrosine kinase inhibitors (i.e. erlotinib, gefitinib, crizotinib) were evaluated for their cytotoxic activity against the A549 cell line. Combination of erlotinib and fisetin at 1: 2 molar ratio, showed the highest synergism in cell killing, when analysed using the median effect principle method. This combination was then used to form a complex with SBE-β-CD. Further improvement in the solubility of erlotinib and fisetin, was achieved with the addition of 50%v/v ethanol during complexation, compared to using water alone. The complex solution was lyophilised and reconstituted into a 3-times more concentrated preparation, prior to nebulisation into the NGI. The preparation showed a suitable aerosol size for inhalation of both drugs. In conclusion, cyclodextrin-based formulations in the form of a dry powder inhalation and nebuliser solution, showed promise for pulmonary delivery of fisetin and its combination with erlotinib, respectively, in the treatment of non-small cell lung cancer (NSCLC).
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Sala, Andrea. "Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29711.

Повний текст джерела
Анотація:
The objective of this study was to modify the physicochemical properties of two common drugs via supramolecular derivatization. Sulfasalazine is a powerful anti-inflammatory drug and fluconazole has a strong antibacterial and antifungal activity. The common feature is their very low solubility in water. Cyclodextrin inclusion complexation and co-crystallization were carried out with the aim of ultimately improving the bioavailability of both drugs. Each new crystal phase isolated was analysed using X-ray diffraction, thermal and spectroscopic techniques. Sulfasalazine presents two tautomeric forms which were isolated using different preparative methods via recrystallization from different solvents. Each form was used in combination with nine different co-formers in attempts to form co-crystals. This approach yielded negative results. Cyclodextrin inclusion complexation of sulfasalazine was studied with a variety of cyclodextrins (αCD, β-CD, γ-CD, dimethylated β-CD and permethylated β-CD). The complexation attempts yielded an inclusion complex between one of the tautomers of sulfasalazine and γ-cyclodextrin. No single crystals were obtained and hence it was impossible to resolve the crystal structure. However, it was possible to analyse the complex thermally and spectroscopically. The co-crystallization of fluconazole with biocompatible co-formers was not investigated due to the appearance of extensive previous reports on its co-crystal formation in the literature. Thus, only cyclodextrin inclusion complexation (with the same CDs listed above) was studied. Three inclusion complexes with native CDs were successfully prepared. Two crystallographically distinct complexes of β-CD with fluconazole as guest having 2:1 host-guest stoichiometry were isolated. While these two hydrated complexes had been identified recently by previous researchers and the X-ray structure of one of the crystal forms had been partially resolved, their characterization was incomplete. In the present study, significant advances on the previous work included the complete X-ray structural resolution of both crystal forms, designated TBCDFLU (triclinic) and MBCDFLU (monoclinic), as well as a systematic study of the conditions under which these individual forms could be isolated. The occurrence of these crystal forms was dependent on two variables, namely β-CD concentration in the aqueous mother liquor and the incubation temperature of the solution. Careful examination of the sensitive crystallization equilibrium indicated that, at a solution concentration of 6.52  10-2 M, pure TBCDFLU could be isolated at an incubation temperature of 45 C or lower, while pure MBCDFLU crystallized at an incubation temperature of 60 C (for both cases the incubation period is more than 48 h). MBCDFLU and TBCDFLU crystals displayed different stabilities with respect to dehydration when exposed to air and hence determination of their respective water contents was performed using thermogravimetry on fresh crystals immersed in silicone oil. From a phase solubility study, it was established that the association constant for complex formation between - CD and fluconazole in solution was very low (27.2 M-1), implying weak host-guest binding. Finally, a 1:1 inclusion complex between -CD and fluconazole was isolated and characterized by thermal and spectroscopic techniques.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Mvula, Eino Natangwe. "Preparation and solid state properties of cyclodextrin complexes of selected drug molecules." Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/17902.

Повний текст джерела
Анотація:
Includes bibliographical references.
A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis.
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Wandstrat, Michelle Marie. "MATERIALS AND MODIFICATION OF ELECTRODES FOR THE DETECTION OF BIOLOGICAL MOLECULES." Miami University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=miami1164817458.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Dutta, Ashutosh. "Exploration of diversified interactions of some significant compounds prevalent in several environments by physicochemical contrivance." Thesis, University of North Bengal, 2018. http://ir.nbu.ac.in/handle/123456789/2787.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Wahlström, Anna. "NMR studies on interactions between the amyloid β peptide and selected molecules". Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-60346.

Повний текст джерела
Анотація:
Alzheimer’s disease is an incurable neurodegenerative disorder linked to the amyloid β (Aβ) peptide, a 38-43 residue peptide. The detailed molecular disease mechanism(s) is (are) unknown, but oligomeric Aβ structures are proposed to be involved. In common for the papers in this thesis is interactions; interactions between Aβ(1-40) and selected molecules and metal ions. The purpose has been to find out more about the structural states that Aβ can adopt, in particular the β-sheet state, which probably is linked to the oligomeric structures. The methods used have been nuclear magnetic resonance (NMR), circular dichroism (CD) and fluorescence spectroscopy using Thioflavin T (ThT). Upon addition of SDS/LiDS detergent or Congo red (CR) to Aβ(1-40), the initial random coil/PII-helix state was transformed into β-sheet and, in the case of detergent, a final α-helical state. In contrast to SDS/LiDS and CR, the dimeric Affibody molecule locks monomeric Aβ(1-40) in a β-hairpin state. It was found that by truncating the flexible N-terminal end of the Affibody molecule its affinity to Aβ was improved. The aggregation of Aβ(1-40) was further studied in the presence of a β-cyclodextrin dimer by a kinetic assay using ThT. Although having a weak dissociation constant in the millimolar range, the β-cyclodextrin dimer modified the aggregation pathways of Aβ. Finally Aβ(1-40) was studied in presence of Cu2+ and Zn2+ at physiological and low pH. Cu2+ was observed to maintain its specific binding to Aβ when decreasing the pH to 5.5 while Zn2+ behaved differently. This could be of importance in the Alzheimer’s disease brain in which the environment can become acidic due to inflammation.        In conclusion the results show that Aβ(1-40) is very sensitive to its environment, responding by adopting different conformations and aggregating in aqueous solutions. The β-sheet state is induced by varying molecules with different properties, properties that govern the final Aβ state.
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 4: Manuscript. Paper 5: Manuscript.
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Brown, Susan Elizabeth. "Molecular recognition by cyclodextrins /." Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phb8798.pdf.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Cherraben, Sawsen. "Machines moléculaires à base de cyclodextrines fonctionnalisées." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS633.pdf.

Повний текст джерела
Анотація:
Le contrôle du mouvement et de sa directionnalité à l’échelle moléculaire est un défi actuel. Ce travail de thèse s’est intéressé à l’élaboration d’une famille de machines moléculaires à base de cyclodextrines (CDs). L’objectif a été d’exploiter l’asymétrie intrinsèque des CDs et de les fonctionnaliser sélectivement afin de pouvoir leur appliquer directement un stimulus. Nous pouvons dès lors contrôler leurs mouvements dans des architectures supramoléculaires. Dans une première approche, nous avons développé un commutateur pH-sensible de type pseudo-rotaxane à base de CDs sélectivement fonctionnalisées par des amines sur le col primaire. Un contrôle de l’enfilage et du désenfilage par un stimulus pH et une modulation de la cinétique de désenfilage par variation du nombre d’amines ont été obtenus. Dans une deuxième approche, nous avons conçu un système utilisant un carburant chimique pour obtenir un mouvement unidirectionnel par le transport actif d’une CD fonctionnalisée. Le point clé est l’étape de clivage de groupements protecteurs sur l’axe par la fonction catalytique portée par la CD, qui devrait avoir lieu préférentiellement par le col primaire et assurer son transport dirigé. Pour cela, un premier [2]rotaxane modèle de CDMe à trois stations a été synthétisé par une approche de post-fonctionnalisation d’un [2]rotaxane, avec des bouchons amides. Son étude a montré la formation de 3 mécano-isomères lors de la réaction de protection avec une distribution non-statistique indiquant un probable biais cinétique. Ces travaux prometteurs ouvrent des perspectives à plus long terme sur l’obtention de moteurs moléculaires à énergie chimique avec un transport actif de la CD
Controlling motion and directionality at the molecular level is a major challenge. This thesis project focused on the development of a family of cyclodextrin (CDs) based molecular machines. The objective was to exploit the inherent asymmetry of CDs and to functionalize them selectively in order to be able to apply a stimulus directly to them. Hence, controlling their movements in supramolecular architectures becomes possible. In the first approach, we developed a pH-sensitive switch of the pseudo-rotaxane type based on CDs selectively functionalized by amines on the primary rim. A remarkable control of threading and dethreading by a pH stimulus were obtained, along with a modulation of the dethreading kinetics by variation in the number of amines. In a second approach, we designed a system using a chemical fuel to obtain unidirectional motion of a functionalized CD through its active transport. The key step is the cleavage of protective groups located on the axis by the catalytic function carried by the CD, which should preferably take place through the primary rim, ensuring its directed transport. For this purpose, a first three-station [2]rotaxane CDMe model was synthesized by a post-functionalization approach of a one-station [2]rotaxane with amide stoppers. Its study showed the formation of 3 mechano-isomers during the protective reaction with a non-statistical distribution indicating a probable kinetic bias. This promising work opens up longer-term perspectives on the development of chemically fueled molecular motors with active CD transport
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Mansour, Ali Taher. "New enantioselective transformations induced by cyclodextrins : applications in the preparation of molecular building blocks of biological interest." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS186/document.

Повний текст джерела
Анотація:
Le but de ce travail était la préparation de dérivés cyclobutaniques du GABA optiquement purs et leur utilisation dans la préparation de γ/α-peptides pouvant adopter une structure tridimensionnelle bien définie. Pour cela, deux stratégies ont été développées. La première consistait en l’utilisation de la β-Cyclodextrine comme hôte supramoléculaire chirale lors de cyclizations photochimiques énantiosélectives. La tentative de cyclisation [2+2] intramoléculaire du N-allyl-N-(4-methoxyphenyl)acrylamide n’a conduit qu’à un δ-lactame issu d’une électrocyclisation 6π. L’électrocyclisation de la 1,3-dihydro-2H-azepin-2-one nous a permis d’obtenir le γ-latame bicyclique précurseur du (+)-cis-3,4CB-GABA avec un excès énantiomérique de 45%. La deuxième stratégie était basée sur une synthèse racémique du N-Boc-cis-3,4CB-GABA suivi d’une séparation des deux énantiomères par CLHP semi-préparative avec une colonne chirale. Les (-) et (+)-cis-3,4CB-GABA optiquement purs ont ainsi été obtenu à l’échelle du gramme. Ces deux énantiomères (-) et (+)-cis-3,4CB-GABA ont ensuite été utilisés pour la préparation de deux séries de peptides mixtes γ/α, diastéréoisomères [(S,S/R) et (R,R/R)] à courtes chaines contenant alternativement le cis-3,4CB-GABA et le D-Alanine. L'analyse des conformations des dipeptides des deux séries par Diffraction des Rayons X, n'a montré aucune interaction intramoléculaire mais plutôt un assemblage de liaisons d'hydrogène intermoléculaires entre les molécules du dipeptide. D'autre part, les études RMN 1D et 2D (en solution) ont montré que le tétrapeptide des séries (S,S/R) pourraient avoir une structure hélicoïdale 12/10, tandis que son analogue diastéréoisomères des séries (R,R/R), a montré, en solution, une nouvelle structure sous forme de ruban 7/9
This work revolves around the synthesis of ennatiomerically pure cyclobutane derivatives of GABA, and their use in the preparation of hybrid γ/α-peptides that could adopt a well-defined three dimensional secondary structure. In this aim we developed two strategies. The first one employed native β-Cyclodextrin as a supramolecular chiral host to achieve enantiodifferentiating photochemical cyclizations. Attempting to perform an intramolecular [2+2] cyclization of N-allyl-N-(4-methoxyphenyl)acrylamide, we only obtained a δ-lactam resulting from a 6π electrocyclization, whereas the electrocyclization of 1,3-Dihydro‑2H‑azepin-2-one allowed access to a 45% enantiomerically enriched bicyclic γ-lactam precursor of (+)-cis-3,4CB-GABA. The second strategy was based on a racemic synthesis of N-Boc-cis-3,4CB-GABA followed by a separation of the two enantiomers using a semi-preparative HPLC fitted with a chiral column. This allowed access to optically pure (-) and (+)-cis-3,4CB-GABA, on a gram scale. Furthermore, the enantiomerically pure (-) and (+)-cis-3,4CB-GABA, were used to synthesize, and fully characterize two series [the (S,S/R) and the (R,R/R)] of short diasteriomeric hybrid γ/α-peptides composed of alternating cis-3,4CB-GABA and D-Alanine. Analysis of the conformational behavior of the dipeptides from both series by X-Ray diffraction on a single crystal, showed no intramolecular interactions but rather an array of intermolecular hydrogen bonding between the dipeptide molecules. On the other hand, a series of 1D and 2D NMR experiments showed that the tetrapeptide of the (S,S/R)-series could attain a 12/10 helical structuration, whereas its diasteriomeric analog of the (R,R/R)-series, displayed evidence of an unprecedented 7/9 folding pattern in solution
Стилі APA, Harvard, Vancouver, ISO та ін.
Більше джерел

Книги з теми "Cyclodextrin Molecules"

1

Ahern, Cormac. Dendrimeric cyclodextrins for molecular inclusion. Dublin: University College Dublin, 1997.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Hartwell, Edward Y. Chemically-modified and immobilised cyclodextrins as molecular reaction vessels. Birmingham: University of Birmingham, 1994.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Mareeswaran, Paulpandian Muthu, Palaniswamy Suresh, and Seenivasan Rajagopal, eds. Photophysics of Supramolecular Architectures. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150491901220101.

Повний текст джерела
Анотація:
This reference provides collective information about the physical and photophysical changes of supramolecules after encapsulation. It covers luminescent systems involving a range of host molecules such as calixarenes, cyclodextrin, resorcinanene-crowns, pillararenes, cucurbituril, and metallacycles. Chapters also discuss the effect of the macrocyclic environment on the properties of functionalized molecules, including the variations in folding and unfolding patterns. Each chapter is supplemented with detailed references, making this an ideal resource for scholars interested in supramolecular photophysics.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

(Editor), J. L. Atwood, J. E. Davies (Editor), and T. Osa (Editor), eds. Clathrate Compounds, Molecular Inclusion Phenomena and Cyclodextrins (Advances in Inclusion Science). Springer, 1985.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Davies, J. E., T. Osa, and J. L. Atwood. Clathrate Compounds, Molecular Inclusion Phenomena, and Cyclodextrins: Proceedings of the Third International Symposium on Clathrate Compounds and Molecular Inclusion Phenomena and the Second International Symposium on Cyclodextrins, Tokyo, Japan, July 23-27 1984. Springer, 2012.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Davies, J. E., T. Osa, and J. L. Atwood. Clathrate Compounds, Molecular Inclusion Phenomena, and Cyclodextrins: Proceedings of the Third International Symposium on Clathrate Compounds and ... 23–27, 1984. Springer, 2011.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.

Частини книг з теми "Cyclodextrin Molecules"

1

Harata, K., K. Uekama, M. Otagiri, and F. Hirayama. "Crystal Structures of Cyclodextrin Complexes with Chiral Molecules." In Clathrate Compounds, Molecular Inclusion Phenomena, and Cyclodextrins, 583–94. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-009-5376-5_62.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Ribeiro-Claro, Paulo J. A., and Ana M. Amado. "Structural Rigidity Vs. Structural Disorder in α-Cyclodextrin Inclusion Compounds." In Spectroscopy of Biological Molecules: Modern Trends, 269–70. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5622-6_120.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Sanz-Garcia, T., G. Gonzalez-Gaitano, N. Iza, A. Galvez-Garcia, and G. Tardajos. "NMR Study of the Inclusion Complex Between β-Cyclodextrin and Propafenone." In Spectroscopy of Biological Molecules: New Directions, 333–34. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4479-7_149.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Konsta, A. A., and L. Apekis. "Investigation of β-Cyclodextrin Inclusion Complexes by Broad Band Dielectric Spectroscopy." In Spectroscopy of Biological Molecules: Modern Trends, 273–74. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5622-6_122.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Bügler, Jürgen H., Menno de Jong, Johan F. J. Engbersen, and David N. Reinhoudt. "Functionalized Cyclodextrin-Calix[4]Arene Host Molecules for Detection of Organic Analytes." In Sensor Technology in the Netherlands: State of the Art, 305–9. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5010-1_49.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Junquera, Elena, Oscar Pastor, and Emilio Aicart. "Encapsulation of the Salicylic Acid/Salicylate System by Hydroxypropyl-β-Cyclodextrin at 25 °C. A Fluorescence Enhancement Study in Aqueous Solutions." In Spectroscopy of Biological Molecules: Modern Trends, 397–98. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5622-6_178.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Breslow, Ronald. "Cyclodextrins." In Molecular Encapsulation, 43–69. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470664872.ch2.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Popova, E. I., I. N. Karpov, I. N. Topchieva, and O. I. Mikhalev. "Molecular Necklaces Containing Reporter Molecules." In Proceedings of the Ninth International Symposium on Cyclodextrins, 563–66. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4681-4_134.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Jicsinszky, L., H. Hashimoto, K. Mikuni, I. Bakó, and L. Szente. "Molecular Mechanics Studies on Cyclodextrin Complexes: Interaction of Crocetin with Cyclodextrins." In Proceedings of the Eighth International Symposium on Cyclodextrins, 263–66. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_57.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Tian, He, and Qiao-Chun Wang. "Cyclodextrin-Based Switches." In Molecular Switches, 301–19. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634408.ch9.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.

Тези доповідей конференцій з теми "Cyclodextrin Molecules"

1

Nozawa, Ryo, Mohammad Ferdows, Kazuhiko Murakami, and Masahiro Ota. "Effects of Cyclodextrin Solutions on Methane Hydrate Formation." In ASME/JSME 2007 Thermal Engineering Heat Transfer Summer Conference collocated with the ASME 2007 InterPACK Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ht2007-32987.

Повний текст джерела
Анотація:
In this paper, we suggest the advanced method of methane hydrate formation by cyclodextrin solutions. The structures of the methane hydrate were experimentally investigated by Raman spectroscopy. The induction time of the methane hydrate formation becomes by shorter 10–30 times and formation rate become by faster 2–4 times originated in the increased methane concentration of hydrate formation water by adding cyclodextrins. The results by the Raman spectroscopy indicate that the structure I methane hydrate is produced and methane molecules exist in both Large and Small cages.
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Mic, Mihaela, Adrian Pı̂rnău, Mircea Bogdan та Ioan Turcu. "Inclusion complex of benzocaine and β-cyclodextrin: [sup 1]H NMR and isothermal titration calorimetry studies". У PROCESSES IN ISOTOPES AND MOLECULES (PIM 2013). AIP, 2013. http://dx.doi.org/10.1063/1.4833697.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Zavodnik, I. B., E. A. Lapshina, T. V. Ilyich, A. G. Veiko, T. A. Kovalenia, and V. U. Buko. "REGULATORY, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF PLANT POLYPHENOLS AND THEIR NANOSTRUCTURED COMPLEXES." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-255-258.

Повний текст джерела
Анотація:
Flavonoids, secondary plant metabolites, demonstrate a wide range of biological and pharmacological activities. In our experiment, flavonoids and their complexes with cyclodextrins (10—100 gM) dose-dependently prevented lipid peroxidation of erythrocyte and mitochondrial membranes, inhibited oxidation of reduced glutathione, and modulated the proapoptotic process of the mitochondrial permeability transition pores formation, that depends on flavonoid lipophilicity and structures. Generation of maps of the electron density distribution in the quercetin molecule and the quercetin semiquinone radical shows that the active electronic orbitals of quercetin and its semiquinone radical are delocalized along the phenolic rings, which, in the case of a radical, increases radical stability. The quercetin-hydroxypropyl-e-cyclodextrin complex proved to be a more effective antioxidant.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Kim, Jin-Baek, Young-Gil Kwon, Hyo-Jin Yun, and Jae-Hak Choi. "Novel molecular resists based on inclusion complex of cyclodextrin." In SPIE's 27th Annual International Symposium on Microlithography, edited by Theodore H. Fedynyshyn. SPIE, 2002. http://dx.doi.org/10.1117/12.474286.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Koudoumas, E., S. Couris, P. Seta, A. Rassat, and S. Leach. "Optical Limiting Action of Methano Fullerenes and Fullerenes Incorporated in Cyclodextrins." In The European Conference on Lasers and Electro-Optics. Washington, D.C.: Optica Publishing Group, 1998. http://dx.doi.org/10.1364/cleo_europe.1998.cthh45.

Повний текст джерела
Анотація:
C60 dissolved in organic solvents is known to exhibit important nonlinear optical response leading to strong optical limiting action. However its solubility is very poor in most of the organic solvents and practically negligible in water. The fullerene molecules are indeed very hydrophobic compounds with a great tendency even in organic solvents to form aggregates. Among the main routes explored to modify their solubility and properties and in order to prevent aggregation, is their insertion in host matrices such as polymer, zeolites or complexing agents such as γ-cyclodextrins and calixarenes).
Стилі APA, Harvard, Vancouver, ISO та ін.
6

WANG, YING, and DAVID F. EATON. "Control of molecular nonlinear optical properties by inclusion complexation with cyclodextrin." In Conference on Lasers and Electro-Optics. Washington, D.C.: OSA, 1985. http://dx.doi.org/10.1364/cleo.1985.thm44.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Suharyani, Ine, Cecep Suhandi, Yayan Rizkiyan, Didi Rohadi, Muchtaridi Muchtaridi, Nasrul Wathoni та Marline Abdassah. "Molecular docking in prediction of α-mangostin/cyclodextrin inclusion complex formation". У 3RD INTERNATIONAL CONFERENCE OF BIO-BASED ECONOMY FOR APPLICATION AND UTILITY. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0120782.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Treetharnmathurot, Benjaporn, Chitchamai Ovatlarnporn, Juraithip Wungsinthaweekul, and Ruedeekorn Wiwattanapatapee. "Chemical modification and thermal stability study of β-cyclodextrin- and PAMAM-trypsin conjugates." In 2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2009. http://dx.doi.org/10.1109/nems.2009.5068732.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Srihakulung, Ornin, Luckhana Lawtrakul, Pisanu Toochinda, Waree Kongprawechnon, Apichart Intarapanich та Ryo Maezono. "Theoretical investigation of molecular calculations on inclusion complexes of plumbagin with β-cyclodextrins". У 2017 Fourth Asian Conference on Defence Technology - Japan (ACDT). IEEE, 2017. http://dx.doi.org/10.1109/acdtj.2017.8259589.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Belosludov, Rodion V., Hiroshi Mizuseki, Kyoko Ichinoseki, and Yoshiyuki Kawazoe. "Theoretical Study on Inclusion Complex of Polyaniline Covered by Cyclodextrins for Molecular Device." In 2001 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2001. http://dx.doi.org/10.7567/ssdm.2001.f-7-2.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
Також вас можуть зацікавити розширені добірки на тему "Cyclodextrin Molecules" для конкретних типів джерел:
Статті в журналах Дисертації
Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!

До бібліографії