Дисертації з теми "Current standard"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "Current standard".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Lindsey, Bradley P. Landsman Wayne R. Maydew Edward L. "A value relevance examination of the current leasing standard." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,381.
Повний текст джерелаTitle from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Kenan- Flagler Business School (Accounting)." Discipline: Business Administration; Department/School: Business School, Kenan-Flagler.
Sauvan, E. "Petit périple aux confins du modèle standard avec HERA." Habilitation à diriger des recherches, Université de la Méditerranée - Aix-Marseille II, 2009. http://tel.archives-ouvertes.fr/tel-00439880.
Повний текст джерелаRebane, Martin, and Martin Kolga. "Timberland valuation : Current theory and practice in Estonia and Sweden." Thesis, KTH, Fastigheter och byggande, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-101486.
Повний текст джерелаKachanovich, Aliaksei [Verfasser], and U. [Akademischer Betreuer] Nierste. "Flavour-changing neutral current processes beyond the Standard Model / Aliaksei Kachanovich ; Betreuer: U. Nierste." Karlsruhe : KIT-Bibliothek, 2021. http://d-nb.info/123047577X/34.
Повний текст джерелаJoyner, Kate. "Health care for intimate partner violence : current standard of care and development of protocol management." Thesis, Stellenbosch : Stellenbosch University, 2009. http://hdl.handle.net/10019.1/2515.
Повний текст джерелаENGLISH ABSTRACT: The World Health Organisation recognises intimate partner violence (IPV) to be of major consequence to women’s mental and physical health, yet in South Africa it remains a neglected area of care. Within a professional action research framework, this study implemented a previously recommended South African protocol for the screening and holistic management of IPV in women in order to test its feasibility and to adapt it for use in the primary health care (PHC) sector of the Western Cape. It also aimed to identify the current nature of care offered to female survivors of IPV. Thirdly, it aimed to learn from the process of training and supporting (nurse) researchers who were new to the action research paradigm and methodology. Successfully implementing and evaluating a complex health intervention in the current PHC scenario required a flexible methodology which could enable real engagement with, and a creative response to, the issues as they emerged. Guided by the British Medical Research Council’s framework for development and evaluation of randomised controlled trials for complex health interventions (Medical Research Council, 2000, p.3), this study was positioned within the modelling phase. Professional action research used a co-operative inquiry group process as the overarching method with the usual cycles of action, observation, reflection and planning. Altogether five co-researchers were involved in implementing the protocol and were members of the inquiry group. A number of techniques were used to observe and reflect on experience, including participant interviews, key informant interviews, focus groups with health care providers at each site, quantitative data from the medical records and protocol, field notes and academic literature.
AFRIKAANSE OPSOMMING: Die Wêreld Gesondheidsorganisasie erken dat geweldpleging in intieme verhoudings (“intimate partner violence”, of IPV) ‘n groot impak het op vroue se geestes- en fisiese gesondheid, terwyl dit ʼn verwaarloosde area van sorg in Suid-Afrika is. Binne ‘n professionele aksie-navorsingsraamwerk, implementeer hierdie studie ‘n voorheen aanbevole Suid-Afrikaanse protokol vir die sifting en holistiese hantering van IPV by vroue om die uitvoerbaarheid daarvan te toets en om dit aan te pas vir gebruik in die primêre gesondheidsorgsektor (PGS) van die Wes-Kaap. Die projek poog ook om die huidige aard van sorg wat aan vroulike oorlewendes van IPV beskikbaar is, te identifiseer. Derdens het dit ook ten doel om te leer van die proses van opleiding en ondersteuning van (verpleeg-) navorsers vir wie die aksie-navorsingsparadigma en methodologie nuut was. Suksesvolle implementering en evaluering van ‘n komplekse gesondheidsintervensie in die huidige PGS scenario vereis ‘n buigsame methodologie wat betrokkenheid met, en ‘n kreatiewe respons tot, kwessies soos wat dit ontwikkel, moontlik maak. Gelei deur die Britse Mediese Navorsingsraad se raamwerk vir die ontwikkeling en evaluering van ewekansige gekontroleerde proewe vir komplekse gesondheidsintervensies (Mediese Navorsingsraad, 2000, bl.3), was hierdie studie binne die modelleringsfase geposisioneer. Professionele aksienavorsing het ‘n gekoördineerde ondersoekgroep as die oorkoepelende metode - met die normale siklusse van aksie, waarneming, reflektering en beplanning - gebruik. Altesaam vyf mede-navorsers wat lede van die ondersoekgroep was, was betrokke in die implementering van die protokol. ‘n Aantal tegnieke is gebruik om waar te neem en te reflekteer op ervarings, insluitend deelnemersonderhoude, sleutel-informant onderhoude, fokusgroepe met gesondheidsorgverskaffers by elke fasiliteit, kwantitatiewe data van die mediese verslae en protokol, veldnotas en akademiese literatuur.
Farmer, Brooke Michael. "Wake Forest University Art Collection: Current State and Recommendations for Future Use." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd_retro/19.
Повний текст джерелаBerg, Anthon, and Felicia Svantesson. "Is your electric vehicle plotting against you? : An investigation of the ISO 15118 standard and current security implementations." Thesis, Högskolan i Halmstad, Akademin för informationsteknologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-44918.
Повний текст джерелаBerakis, Michael T. "The connection between the current penetration based national ambient air quality standard and dose can be considered questionable." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=1111.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains vii, 301 p. : ill. Includes abstract. Includes bibliographical references (p. 146-48).
Watkins, Fred P. "Independent Feature Filmmaking: the Historical Development of Current Methods." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc500788/.
Повний текст джерелаBurrage, Anna Lucy. "A study of radiative charged current interactions in ep collisions." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343862.
Повний текст джерелаShaheed, Rawaa. "3D Numerical Modelling of Secondary Current in Shallow River Bends and Confluences." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34922.
Повний текст джерелаVadnerkar, Sarang. "An Algorithm for the design of a programmable current mode filter cell." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1261601029.
Повний текст джерелаLewis, Andrew Peter. "Muscle impairment in cerebral palsy : does the current 'standard' method of simulating muscle activations during human walking produce valid results?" Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/muscle-impairment-in-cerebral-palsy(3b54bd41-f1e3-4077-b9fe-4105c22552b4).html.
Повний текст джерелаHeim, Marcus Edwin Allan. "ANALYSIS OF MOS CURRENT MODE LOGIC (MCML) AND IMPLEMENTATION OF MCML STANDARD CELL LIBRARY FOR LOW-NOISE DIGITAL CIRCUIT DESIGN." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1422.
Повний текст джерелаEygi, Zeynep Deniz. "The Standard Model Analyasis Of The Cp Violation In The Inclusive Semileptonic B-meson Decays." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12604712/index.pdf.
Повний текст джерелаviolating asymmetry and CP &ndash
violating asymmetry in the forward-backward asymmetry in these processes are examined.The dependencies of these physical parameters on the Standard Model parametres are analyzed by paying a special attention to the long distance effects. Although the branching ratios predicted for the inclusive semileptonic B- meson decays are relatively small because of CKM suppression , it has been found that there is a significant ACP and ACP(AFB) for these processes.
SILVA, MÁRCIO THELIO FERNANDES DA. "DESIGN & DEVELOPMENT OF A STANDARD FOR HIGH VOLTAGE IN DIRECT CURRENT IN THE RANGE OF 1 KV TO 50 KV." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2011. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=17889@1.
Повний текст джерелаMetrologia e qualidade estão intimamente relacionadas e constituem-se em poderoso instrumento de transformação da infraestrutura tecnológica de países e organizações. O avanço do desenvolvimento científico e tecnológico está fortemente embasado no avanço da metrologia. O Instituto Nacional de Metrologia, Normalização e Qualidade industrial (INMETRO) é o órgão máximo responsável pela conservação e manutenção das unidades de base e derivadas do Sistema Internacional de Unidades (SI) no país. A grandeza tensão em corrente contínua, até 1 kV, está disponível e rastreada a padrões nacionais na Rede Brasileira de Calibração (RBC). Contudo, para tensões maiores que 1 kV, pois ainda carece de laboratórios acreditados pelo INMETRO para prestar serviços para a indústria de equipamentos elétricos em Alta Tensão em Corrente Contínua (HVDC). Deve-se considerar, ainda, que novos investimentos na geração e transmissão em larga escala de energia mobilizam a indústria e geram demanda para ensaios em novos equipamentos que serão instalados. Para realizar esses ensaios, de forma a garantir exatidão, confiabilidade e rastreabilidade, é necessária uma estrutura metrológica em Alta Tensão, ou seja, é preciso criar padrões e incentivar a acreditação de laboratórios. Nesse sentido o objetivo desta dissertação foi à construção de um protótipo de Divisor para Alta Tensão (DVAT) do tipo resistivo de alta impedância, para medição da grandeza tensão em corrente contínua acima de 1 kV. O padrão foi construído para ser utilizado na faixa de 1 kV a 50 kV e será calibrado em baixa tensão rastreado à RBC. Em alta tensão será o elo na cadeia de rastreabilidade entre o padrão do INMETRO e os divisores dos laboratórios industriais e também na calibração de padrões de trabalho para HVDC na faixa de 1 kV a 250 kV.
Metrology and quality are closely related and constitute a powerful tool for transforming the technological infrastructure of countries and organizations. The advancement of scientific and technological development is strongly grounded in the advancement of metrology. The National Institute of Metrology, Standardization and Industrial Quality (INMETRO) is the highest organism responsible by the conservation and maintenance of base and derived units of the International System of Units (SI) in the country. The quantity voltage, up to 1 kV, is traced to national standards in the Brazilian Calibration Network (RBC), but for voltages above 1 kV there is no laboratory in the country accredited by INMETRO to provide services for the electrical equipment industry in HVDC. It should also be considered that new investments in generation and transmission of large scale energy mobilize the industry and generates demand for testing of new equipment. To perform these tests, so as to ensure reliability, accuracy and traceability, a metrology structure is needed in high voltage, so it is necessary to create standards and encourage the accreditation of laboratories. In this sense the main purpose of this dissertation was to build a prototype for a standard High Voltage Divider (DVAT) of the high impedance resistive type for measuring the quantity voltage above 1 kV. The standard was designed for use in the range of 1kV to 50 kV and will be calibrated in low voltages and traceable to the RBC. In the high voltage range, it will be the link in the chain of traceability between INMETRO standards and the dividers of industrial laboratories, and also to calibrate other working standards for HVDC, especially in the range of 1 kV to 250 kV.
Tayarani-Binazir, Kayhan Ashley. "Behavioural investigation into whether L-DOPA, the current 'gold standard' pharmacotherapy for Parkinson's disease, can be improved by optimising its treatment strategies." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/behavioural-investigation-into-whether-ldopa-the-current-gold-standard-pharmacotherapy-for-parkinsons-disease-can-be-improved-by-optimising-its-treatment-strategies(0b62fd27-f368-4ff3-aeb3-e28ef5deb0cb).html.
Повний текст джерелаO'Reid, Esmerelda. "The impact of monetary compensation as a form of land restitution on the current life-styles of Paarl residents." Thesis, Peninsula Technikon, 2002. http://hdl.handle.net/20.500.11838/1655.
Повний текст джерелаRestitution is a constitutionally mandated programme aimed at redressing the injustices of the apartheid era. Land rights are being addressed via a legal administrative process in order to make some form of reparation. The mission of the Commission on the Restitution on Land Rights is to have persons or communities, in the Western Cape province, who were dispossessed of property after 19 June 1913 as a result of past racially discriminatory laws or practices, restored to such property or receive just and equitable redress. The restitution process is the first programme in South Africa that aims to restore people to the land from where they were dispossessed. The processes and procedures involved are very complex, which could result in slow delivery. The research attempts to determine the impact of monetary compensation as a form of land restitution on the current life-styles of Paarl residents. The research will focus on financially settled claims. The reason for selecting Paarl as a case study was because of the demographics and diversity of the region. This study also includes the history of forced removals in South Africa as well as the local international restitution processes. The study has a descriptive approach. Primary data will be collected by means of questionnaires based on the living standard measurement. The questionnaires will focus on the life-styles of people prior to dispossession and their life-styles after receiving their restitution awards. This study may provide a positive or a negative critique on the restitution process. The study attempted to determine whether restitution provides a better quality of life to the disadvantaged, displaced people of our country and provides an indicator for future similar endeavours.
Reid, Esmeralda O. "The impact of monetary compensation as a form of land restitution on the current life-styles of Paarl residents." Thesis, Peninsula Technikon, 2002. http://hdl.handle.net/20.500.11838/1666.
Повний текст джерелаRestitution is a constitutionally mandated programme aimed at redressing the injustices of the apartheid era. Land rights are being addressed via a legal administrative process in order to make some form of reparation. The mission of the Commission on the Restitution on Land Rights is to have persons or communities, in the Western Cape province, who were dispossessed of property after 19 June 1913 as a result of past racially discriminatory laws or practices, restored to such property or receive just and equitable redress. The restitution process is the first programme in South Africa that aims to restore people to the land from where they were dispossessed. The processes and procedures involved are very complex, which could result in slow delivery. The research attempts to determine the impact of monetary compensation as a form of land restitution on the current life-styles of Paarl residents. The research will focus on financially settled claims. The reason for selecting Paarl as a case study was because of the demographics and diversity of the region. This study also includes the history of forced removals in South Africa as well as the local international restititution processes. The study has a descriptive approach. Primary data will be collected by means of questionnaires based on the living standard measurement. The questionnaires will focus on the life-styles of people prior to dispossession and their life-styles after receiving their restitution awards. This study may provide a positive or a negative critique on the restitution process. The study attempted to determine whether restitution provides a better quality of life to the disadvantaged, displaced people of our country and provides an indicator for future similar endeavours.
OLIVEIRA, YURI DOS REIS. "DEVELOPMENT OF ALGORITHMS FOR ESTIMATING PARAMETERS OF HIGH VOLTAGE DIRECT AND ALTERNATING CURRENT TESTS IN ACCORDANCE WITH THE STANDARD ABNT NBR IEC 60060-1: 2013." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2017. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30269@1.
Повний текст джерелаCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
Os ensaios dielétricos em equipamentos para alta tensão em corrente alternada (ATCA) e corrente contínua (ATCC) requerem medições de grandezas elétricas, e as análises de desempenho dos equipamentos ensaiados são diretamente dependentes dos resultados obtidos por tais medições. Atualmente, para garantir a confiabilidade dos resultados dos ensaios, é necessário que a forma de onda da tensão aplicada ao equipamento esteja dentro dos níveis de distorção exigidos por norma. Para que ensaios possam ser realizados de forma normalizada, todos os parâmetros descritos na norma ABNT NBR IEC 60060-1:2013 devem ser monitorados durante os ensaios em ATCA e ATCC. Normalmente um Sistema de Medição para Alta Tensão (SMAT) é formado por um divisor de tensão, um cabo de transmissão e um multímetro de bancada, permitindo assim uma análise quantitativa da tensão de ensaio por meio da medição do valor eficaz e/ou do valor médio. Entretanto, esse SMAT é inadequado para o monitoramento de todos os parâmetros normalizados, restringindo sua aplicação a uma análise puramente quantitativa da tensão de ensaio. Deste modo, o objetivo desta dissertação foi o desenvolvimento e validação de algoritmos de medição que fossem capazes de estimar todos os parâmetros normalizados. Sua validação foi realizada mediante ensaios experimentais em alta e baixa tensão, assim como pelo processamento das formas de onda digitais padrão pertencentes ao rascunho da norma IEC 61083-4. Os resultados obtidos foram positivos e dentro de limites aceitáveis, possibilitando a implantação desses algoritmos de medição nos laboratórios de ensaios (AT1, AT2, AT3, LabUAT) do CEPEL.
Dielectric tests on equipment with high voltage alternating current (HVAC) and direct current (HVDC) require measurements of electrical quantities, and the performance analysis of the tested equipment is directly dependent on the results obtained by those measurements. Currently, to ensure the reliability of the test results, the voltage waveforms applied to the equipment must be within the distortion levels required by standard. For tests to be performed in a standardized way, all parameters described in ABNT NBR IEC 60060-1: 2013 must be monitored during the HVAC and HVDC tests. Normally, a High Voltage Measurement System is formed by a voltage divider, a transmission cable and a multimeter, allowing a quantitative analysis of the test voltage by measuring the RMS value and/or mean value. However, this High Voltage Measurement System is inadequate for the monitoring all standard parameters, restricting its application to a purely quantitative analysis of the test voltage. Therefore, the objective of this dissertation was the development and validation of measurement algorithms that are able to estimate all the normalized parameters. Its validation was carried out through experimental tests in high and low voltage, as well as by the processing of the standard digital waveforms belonging to the draft of the standard IEC 61083-4. The results were positive and within acceptable limits, allowing the implementation of these measurement algorithms in CEPEL test (AT1, AT2, AT3, LabUAT) laboratories.
Bateebe, Irene. "Investigation of Probable Pollution from Automobile Exhaust Gases in Kampala City, Uganda : To Assess the current automobile exhaust gas emission levels and characterize the emissions from different automobile types." Thesis, KTH, Energiteknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-92013.
Повний текст джерелаDiop, Mor Sokhna. "Simulation numérique CEM du test BCI (Bulk Current Injection) de la norme aéronautique DO 160." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAT045/document.
Повний текст джерелаThis work presents a modeling/simulation approach of BCI (Bulk Current Injection) test under constraint RTCA - DO 160. This qualification test of equipment is very constraining in terms of cost and deadline. During the test, there are also many disparities for which it is difficult to identify sources (and control them) with a physical test setup. The simulation is of interest in the study of phenomena (which can have negative impacts on test results) but also the repeatability of tests.First, a method of modeling for the probe/cables coupling is established which takes into account the variation with frequency of the RF transformer (current probe) of the magnetic ferrite core and the linear parameters of cables (skin/ proximity effects). Two models are proposed in this work:- A generic model which is made up solely of passive elements RLC and elaborated (with SPICE software) from the measurement of S-parameters. It shows the coupling zone between probe and cables (secondary winding).- A magnetic macro-model developed with the Flux2D software. Its geometrical parameters are defined from dimensions of the probe (inner/outer diameter, length) and cables (diameters / length). Physical parameters of the current probe, particularly the complex magnetic permeability of the ferrite core, are obtained from measurement of the S-parameter at the input port of the probe and post-treatment extraction.Frequency domain validations were performed with a good correlation between simulations and measurements in the BCI band ([10 kHz - 400 MHz]).These results led to the development of a complete virtual BCI test (with PAM-CEM / CRIPTE software), which take into account an aeronautic complex harness and a DUT (Device Under Test which is modeled at Ampère laboratory). It consists of disturbance generator, harness model (consisting of shielding twisted cables, no shielding cables, etc.) and DUT (Device Under Test) in the band [10 kHz - 400 MHz].The good correlation between simulations and measurements suggests a use by the aircraft manufacturers or equipment manufacturers for parametric studies about BCI test (uncertainties related to cable positions, pigtail, cable length, DUT position with respect to the ground plane, ...) and /or for virtualization in a pre-qualification phase of the equipment.Keywords: EMC (ElectroMagnetic Compatibility), BCI (Bulk Current Injection) test, Modeling/Simulation, DO 160 aeronautic standard
Marusiak, David. "MOS CURRENT MODE LOGIC (MCML) ANALYSIS FOR QUIET DIGITAL CIRCUITRY AND CREATION OF A STANDARD CELL LIBRARY FOR REDUCING THE DEVELOPMENT TIME OF MIXED-SIGNAL CHIPS." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1363.
Повний текст джерелаNdou, Fulufhelo Clyde. "The legal protection afforded to the consumer under current South African law with emphasis on the legal position in specific credit agreements contained in standard-form contracts." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1003203.
Повний текст джерелаDragana, Naumović Vuković. "Prilog savremenom etaloniranju strujnih mernih transformatora." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107383&source=NDLTD&language=en.
Повний текст джерелаThe dissertation presents the concept, its realisation and verification of the new methodof simultaneous comparison of the current transformers by two different measuringapparatus. It is shown by searching the literature, that this method has not been usedbefore. In this dissertation different measuring methods for testing and calibration ofcurrent transformers, with their different measuring capabilities are presented. Most ofthem have been used in recent practice. Furthermore, the experimental verification ofnew simultaneous calibration method is presented. For this reason some measuringapparatus based on different measuring methods were used. Conducted research andexperimental results confirmed a number of advantages of this calibration method.Detailed analysis of the components of the uncertainty of measurements shown thatusing simultaneous method uncertainty of measurements have been improvedcomparing to method with two individual calibration by different apparatus. In that casesome of the measuring uncertainty components can be neglected. The most significantis component caused by variation of referent current and component caused by variationof burden. The research has also showed that simultaneous method can be used forcalibration of measuring apparatus for current transformer accuracy testing and theirinter-comparisons. The ways of calibration of apparatus for current transformer accuracytesting are considered and presented, through concrete examples realized in practice.A high-accuracy comparison of two NRC (National Research Council Canada)calibration systems were carried out by new simultaneous method. One measuringsystem is developed at Electrical Engineering institute Nicola Tesla, Belgrade.Accordingly the advantage of simultaneous method applied at the primary metrology ofcurrent transformer is verified.
Niemiec, Łukasz. "Určení nejistot při stanovení průtoků ve vodních tocích pomocí měření hydrometrickou vrtulí." Doctoral thesis, Vysoké učení technické v Brně. Fakulta stavební, 2013. http://www.nusl.cz/ntk/nusl-233793.
Повний текст джерелаCosta, Verdera Helena. "Towards the development of a gene therapy for Pompe disease : Characterization of the immune phenotype in Pompe disease and comparison of the therapeutic potential of gene therapy with the current standard of care." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS516.
Повний текст джерелаPompe disease is a lysosomal storage disease caused by mutations on the enzyme acid α-glucosidase (GAA), responsible for degrading lysosomal glycogen. GAA deficiency causes the accumulation of glycogen in multiple tissues, particularly in muscles and central nervous system, leading to a complex neuromuscular disease with high morbidity and mortality. In addition to the known symptoms, our studies in Pompe disease patients and mice show that GAA deficiency affects the activation and function of immune cells, particularly of T cells, leading to a higher activation of effector cells and impaired induction and suppressive function of regulatory T cells (Tregs). Moreover, Pompe disease mice present tissue inflammation at early stages of the disease, altogether suggesting that alterations in the immune system could contribute to the disease pathophysiology. These findings could open new venues to investigate strategies that delay the progression of the disease. In a second set of experiments we show that liver-directed gene therapy with a secretable GAA transgene results in superior disease rescue in an immunodefficient Pompe disease mouse model, when compared to the current enzyme replacement therapy. Because Tregs play an essential role in liver-directed gene therapy, by inducing immune tolerance towards hepatic transgenes, future studies will have to evaluate the potential impact of immune alterations associated to Pompe disease on the efficacy of liver-targeted gene transfer
La enfermedad de Pompe es una enfermedad lisosomal (lysosomal storage disease, LSD) causada por mutaciones en la enzima α-glucosidasa ácida (GAA), que hidroliza el glucógeno en glucosa en los lisosomas. La disfunción de esta enzima causa la acumulación de glucógeno en múltiples tejidos, principalmente en células musculares y neuronas. Como resultado, los pacientes desarrollan hipertrofia cardíaca, debilidad muscular, insuficiencia respiratoria, alteraciones cognitivas y muerte prematura por paro cardiorrespiratorio. Actualmente la enfermedad de Pompe se trata con terapia de reemplazo enzimático (Enzyme replacement therapy, ERT) con GAA recombinante humana (rhGAA). Este tratamiento ha demostrado corregir la patología cardíaca y extender la esperanza de vida de los pacientes. Sin embargo, la eficacia de la ERT en los músculos respiratorios y esqueléticos es parcial, y nula en el sistema nervioso central (SNC). Además, la proteína rhGAA es altamente inmunogénica, por lo que el tratamiento no es efectivo en ciertos pacientes. Otros inconvenientes son el elevado coste de la ERT y la necesidad de infusiones continuadas a lo largo de la vida del paciente. En este estudio mostramos que la terapia génica dirigida al hígado mediante vectores adeno-asociados (AAV) expresando una versión modificada de la GAA revierte de forma significativa la enfermedad a nivel de la musculatura esquelética y del SNC, en un modelo animal de la enfermedad de Pompe. Además, mostramos que este tratamiento es superior en eficacia al tratamiento estándar por ERT, incluso a dosis reducidas de vector AAV. Con tal de comprender mejor los mecanismos de acción de estos dos tratamientos, hemos llevado a cabo un estudio farmacocinético de los niveles de GAA en circulación y en múltiples tejidos en los dos casos. Dicho estudio muestra que niveles reducidos pero constantes de GAA en circulación proporcionados por el hígado permiten una mayor acumulación de GAA en los tejidos en comparación a la ERT, mejorando así la eficacia del tratamiento. Debido a que las reacciones inmunes contra el vector AAV y el transgén son un obstáculo importante en la aplicación clínica de la terapia génica, y a que alteraciones en los lisosomas han demostrado tener un impacto sobre el sistema inmune en diferentes modelos, también hemos estudiado el sistema inmune en el caso de la enfermedad de Pompe. Mediante estos estudios, hemos observado que la acumulación de glucógeno en los lisosomas de células inmunes está asociada a una mayor activación de estas células, tanto en pacientes como en ratones con enfermedad de Pompe, y particularmente en las células T. Además, ratones con enfermedad de Pompe presentan inflamación en los tejidos ya en las primeras etapas de la enfermedad. Por otra parte, mostramos que el mayor estado de activación de las células T podría deberse a alteraciones en el metabolismo de estas células, como resultado de las alteraciones lisosómicas. Finalmente, los ratones con enfermedad de Pompe presentan un defecto en la inducción de células T reguladoras Foxp3+ (Tregs), y estas células tienen un menor potencial inhibidor en comparación con Tregs de ratones sanos. Alteraciones en el sistema inmunitario podrían contribuir a la fisiopatología de la enfermedad. Por lo tanto, estos hallazgos podrían abrir nuevos caminos para investigar estrategias que retrasen la progresión de la enfermedad. Además, las Tregs juegan un papel esencial en la terapia génica dirigida al hígado, mediante la inducción de tolerancia inmune hacia transgenes expresados por hepatocitos. Por lo tanto, futuros estudios deberán evaluar el impacto de las alteraciones inmunitarias asociadas a la enfermedad de Pompe sobre la eficacia de la terapia génica
La malaltia de Pompe és una malaltia lisosomal (lysosomal storage disease, LSD) deguda a mutacions en l'enzim α-glucosidasa àcida (GAA), que hidrolitza el glicogen en glucosa als lisosomes. La disfunció d'aquest enzim causa l'acumulació de glicogen en múltiples teixits, principalment en cèl·lules musculars i neurones. Com a resultat, els pacients presenten hipertròfia cardíaca, debilitat muscular, insuficiència respiratòria, alteracions cognitives i mort prematura per aturada cardiorespiratòria. Actualment, la malaltia de Pompe és tractada amb teràpia de reemplaçament enzimàtic (Enzyme replacement therapy, ERT) amb GAA recombinant humana (rhGAA). Aquest tractament ha demostrat corregir la patologia cardíaca i estendre l'esperança de vida dels pacients. No obstant, l'eficàcia de l'ERT en els músculs respiratoris i esquelètics és parcial, i nul·la en el sistema nerviós central (SNC). A més, la proteïna rhGAA és altament immunogènica, de manera que el tractament no és efectiu en certs pacients. Altres inconvenients són l'elevat cost de l'ERT i la necessitat d'infusions continuades al llarg de la vida del pacient. En aquest estudi mostrem que la teràpia gènica dirigida al fetge mitjançant vectors adeno-associats (AAV) expressant una versió modificada de la GAA millora de forma significativa la malaltia a nivell de la musculatura esquelètica i del SNC, en un model animal de la malaltia de Pompe. A més, mostrem que aquest tractament és superior en eficàcia al tractament estàndard per ERT, fins i tot a dosis reduïdes de vector AAV. Per tal de comprendre millor els mecanismes d'acció d'aquests dos tractaments, hem dut a terme un estudi farmacocinètic dels nivells de GAA en circulació i en múltiples teixits en ambdós casos. Aquest estudi mostra que nivells reduïts però constants de GAA en circulació proporcionats pel fetge permeten una major acumulació de la GAA en els teixits en comparació a la ERT, millorant així l'eficàcia del tractament. Degut a que les reaccions immunes contra el vector AAV i el transgèn són un obstacle important en l'aplicació clínica de la teràpia gènica, i a que alteracions en els lisosomes han demostrat tenir un impacte sobre el sistema immune en differents models, també hem avaluat el sistema immune en el cas de la malaltia de Pompe. Mitjançant aquests estudis, hem observat que l'acumulació de glicogen en els lisosomes de les cèl·lules immunes està associada a una major activació d'aquestes cèl·lules en pacients i ratolins amb malaltia de Pompe, particularment en les cèl·lules T. A més, ratolins amb malaltia de Pompe presenten inflamació dels teixits ja en les primeres etapes de la malaltia. D’altra banda, hem observat que el major estat d'activació de les cèl·lules T podria ser degut a alteracions en el metabolisme d'aquestes cèl·lules, com a resultat de les alteracions lisosomals. Finalment, els ratolins amb malaltia de Pompe presenten un defecte en la inducció de cèl·lules T reguladores Foxp3+ (Tregs), i aquestes cèl·lules tenen un menor potencial inhibidor en comparació amb les Tregs de ratolins sans. Alteracions en el sistema immunitari podrien contribuir a la fisiopatologia de la malaltia. Per tant, aquestes observacions podrien obrir nous camins a l’hora d’investigar estratègies que retardin la progressió de la malaltia. A més, les Tregs juguen un paper essencial en la teràpia gènica dirigida al fetge, mitjançant la inducció de tolerància immune cap a transgens expressats per hepatòcits. Per tant, futurs estudis hauran d'avaluar l'impacte de les alteracions immunitàries associades a la malaltia de Pompe sobre l'eficàcia del tractament per teràpia gènica
Pop, Ioan Mihai. "Sauts quantiques de phase dans des chaînes de jonctions Josephson." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00586075.
Повний текст джерелаKochebina, Olga. "Study of Rare Charm Decays with the LHCb Detector at CERN." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112208/document.
Повний текст джерелаRare charm decays proceed mostly through the c -> u Flavor Changing Neutral Current (FCNC), which is possible only at loop level in the Standard Model (SM). In charmed decays, FCNCs are subject to a very efficient GIM suppression, leading to very rare processes. Consequently, rare charm decays are good tools to probe to New Physics (NP) beyond the SM. NP particles could become detectable by causing observables such as branching ratios and CP or angular asymmetries to deviate from the SM predictions. The main subject of this thesis is the measurement of the branching ratio of the D0 -> K-π+ ρ/ω (->µ+µ-) mode. It will be precious in the future, in particular as a normalization mode in the study of all: D0 -> h-h’+ µ+µ- decays D0 -> K-π+µ+µ-, D0 -> π+π-µ+µ-, D0 -> K+K-µ+µ- and D0 -> K+π-µ+µ-. Using 2/fb of 2012 LHCb data we find: B(D0 -> K-π+ ρ/ω (->µ+µ-)) = (4.37± 0.12(stat.) ±0.53(syst.)) ×10^-6. This is the first measurement of this mode. We also determined sensitivities to total and partial branching fractions and asymmetries in D0 -> h-h’+ µ+µ- decays with future LHCb datasets. In addition, the systematic uncertainties affecting the searches for the 3-body decays, D+(s) -> π+µ+µ- and D+(s) -> π-µ+µ+, carried out by LHCb based on the data collected in 2011 (1/fb). Finally, the results of the tests of front-end electronic board for the Upgrade of LHCb are presented
Shaheen, Matloob H. "Neutral currents beyond the standard model." Thesis, Durham University, 1988. http://etheses.dur.ac.uk/6334/.
Повний текст джерелаFey, Thomas. "Charakterisierung von organischen Solarzellen an einem neu aufgebauten Laser-basierten DSR-Messplatz." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-182093.
Повний текст джерелаNicol, Michelle. "Analysis of the rare decay B->K*ee at LHCb." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112354/document.
Повний текст джерелаThe high bb cross section produced by the LHC offers an excellent opportunity for thestudy of flavour changing neutral current B decays, where the effects of new physics can be probed. This thesis presents an analysis of the rare decay B->K*ee which can be used to measure the polarisation of the photon in the b -> s transition. When the dilepton mass is low, the ee pair comes predominantly from a virtual photon, and the polarisation can be accessed via an angular analysis. It is predicted to be predominantly left handed in the Standard Model, and therefore an enhanced right handed amplitude would be a sign of new physics. A first step is to measure the branching fraction in the dilepton mass range, 30 MeV to 1 GeV. This decay has not yet been observed in this region, due to its small branching ratio. The analysis involves electrons with low transverse momentum, and is thus experimentally complex in the hadronic environment at the LHC. The branching ratio is measured relative to that of B->J/Psi(ee)K*, which eliminates both certain experimental effects, and the need to determine absolute effciencies. The result is obtained with an integrated luminosity of 1 fb-1 of pp collisions, collected by LHCb during 2011 and is found to be:B(B->K*ee)30-1000MeV = (3:19+0:75-0:68(stat) +/- 0:21(syst) =/-0.15(PDG) x10-7 when using the PDG value for the B->J/Psi(ee)K* branching ratio. The last part of the thesis presents Monte Carlo studies, showing that with the inclusion of the 2012 data sample, the expected sensitivity on the fraction of right handed polarisation is approximately 0.1, which is comparable with the world average obtained with different methods
Horvat, Marko. "Formal analysis of modern security protocols in current standards." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:64d55401-82e1-4fb9-ad0b-73caf2236595.
Повний текст джерелаColl, Eric. "Motion compensated interpolation for television standards conversion." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65468.
Повний текст джерелаLee, Leebong. "Sustainability standards for biofuels : analyses of the current standards and recommendations of the future direction." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/88399.
Повний текст джерелаSome pages printed landscape. Cataloged from PDF version of thesis.
Includes bibliographical references (pages 152-156).
Past decades have seen development and expansion of biofuels industry around the world thanks to the environmental and economic contribution that biofuels have promised. As more and more people became concerned about the real benefits of biofuels in comparison to the conventional fossil-based options, the need for ensuring sustainability of biofuels has emerged, which, in turn, led to the development of numerous sustainability standards for biofuels over the last decade. This work analyzes and compares a selected set of nine standards developed by organizations with different scales and characteristics. Based on this analysis, major weaknesses and limitations of the standards are presented and possible recommendations addressing those weaknesses are provided. It was concluded that one of the major limitations of the nine standards is the lack of harmonization. Many standards deal with different feedstock, products, and scopes of supply chain among others. Therefore, it is suggested that international organizations, particularly the ISO, CEN, RSB, GBEP and FAO take the lead in providing the fundamental common grounds for harmonization of standards. In addition, the inclusion of technological sustainability area is recommended in order to properly address issues that are strongly dependent on the nature of current technologies used.
by Leebong Lee.
S.M. in Technology and Policy
Toupin, Mathieu. "Scientific Validation of Standards for Tidal Current Energy Resource Assessment." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34212.
Повний текст джерелаQuintana, Boris. "Search for radiative B decays to orbitally excited mesons at LHCb." Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAC060.
Повний текст джерелаThis document presents studies of radiative decays of B0 and Bs mesons to orbitally excited states, produced in proton collisions at the Large Hadron Collider (LHC) of CERN (European Council for Nuclear Research). It takes place in the context of the search for new physics processes beyond the standard model of particle physics. The work is based on the data collected at the LHCb experiment during the Run 1(2011-2012) and the Run 2 (2015-2018) of the LHC, which corresponds to an integrated luminosity of about 8.7 fb−1. First, an optimised selection of the final states comprising of two charged tracks and a high energy photon is put in place, regrouping a large samples of B hadron radiative decays. Then, a mass model is fit to the data distribution, allowing to statistically subtract the background contributions in the data set.A first amplitude analysis is then developed to study the hadronic structure in the Bs → K+K−γ decay mode. Resulting from this analysis is the first observation of the Bs → f2j (1525)γ mode together with a relative branching ratio measurement:B(Bs → f2j γ) = (24.1 ± 0.9 (stat) +1.6 (syst) ± 0.6 (br)) × 10−2B(Bs → φγ) −0.8It is the second radiative decay mode observed for the Bs meson. A similar analysis is performed on the B0 → K±π∓γ mode, allowing a preliminary measurement of the relative branching ratio of B0 → K2∗(1430)γ:(B0 K∗0(1430)γ)B(B0 → K∗0(892)γ) = (36.4 ± 0.4 (stat) ± 1.3(BR))%However, a detailed systematics study is needed to assess its competitivity with previous measurements of this decay mode. Making use of a similar selection strategy, a preliminary study of B K0hhγ modes is also set up during the thesis to estimate the available statistics for these modes at LHCb, which are particularly interesting to measure the photon polarisation in the b sγ transition. This work will be the starting point of an analysis comprising the future data that will be collected during the Run 3 of the LHC
Eichlerová, Gabriela. "Možnosti implementace některých standardů IPSAS do české účetní legislativy." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-162530.
Повний текст джерелаWheeling, Barbara Mary. "Contextualizing the harmonization of accounting standards for foreign currency translation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0019/NQ46943.pdf.
Повний текст джерелаDominguez, Didier. "Application de l'effet hall quantique en metrologie : conservation de l'ohm et determination de la constante de structure fine." Paris, CNAM, 1987. http://www.theses.fr/1987CNAM0084.
Повний текст джерелаNolan, Karin. "American Elementary Music Programs: Current Instructional Methods, Goals, Resources, and Content Standards by Geographic Region and Grade Level." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194200.
Повний текст джерелаBillings, Don, Mei Wei, Joseph Leung, Michio Aoyagi, Fred Shigemoto, and Rob Honeyman. "REAL-TIME INTEGRATION OF RADAR INFORMATION, AND GROUND AND RADIOSONDE METEOROLOGY WITH FLIGHT RESEARCH DATA." International Foundation for Telemetering, 1998. http://hdl.handle.net/10150/607368.
Повний текст джерелаAlthough PCM/TDM framed data is one of the most prevalent formats handled by flight test ranges, it is often required to acquire and process other types. Examples of such non-standard data types are radar position information and meteorological data from both ground based and radiosonde systems. To facilitate the process and management of such non-standard data types, a micro-processor based system was developed to acquire and transform them into a standard PCM/TDM data frame. This obviated the expense of developing additional special software and hardware to handle such non-standard data types.
Košťálová, Klára. "Vliv transakcí v cizích měnách na účetnictví podle české legislativy a Mezinárodních standardů účetního výkaznictví (IFRS/IAS)." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-113300.
Повний текст джерелаPollitt, Joanne. "Postretirement benefits other than pensions : recommendations based on a study of relevant standards, conceptual frameworks and current trends." Master's thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/9653.
Повний текст джерелаThe FASB began work in the area of postretirement benefits other than pensions (hereafter OPEB) in the early 1980's. It was to be a long, involved process, culminating in the issue of SF AS 106 in 1990. It was commented at the time that "the proposed standard on non-pension postretirement benefits has been argued to be the most significant accounting change since the adoption of depreciation and the total impact of the standard on corporate profits has been estimated at between $200 billion and a trillion dollars" (Espahbodi et al, 1991 , pp 325). It was SFAS 106 and the well-documented effects thereof that heralded the development of other international accounting standards dealing with OPEB. There is currently little guidance in South Africa as to how OPEB should be both accounted for and disclosed in financial statements. Although AC 305 has been issued, this is merely a guideline and compliance therewith is not compulsory. There is currently some confusion as to whether AC 116, dealing with pensions, applies to other postretirement benefits. In light of this, this thesis aimed to propose an acceptable method of accounting for OPEB in South Africa bearing in mind the possible reactions of management to the disclosure of an OPEB liability and the needs of users of financial statements, who in understanding the complex issues surrounding the provision of postretirement benefits will need extensive disclosures. The TASC's harmonisation process also has to be considered as a South African pronouncement should be consistent with any standards issued by the TASC. In order to achieve this objective, a literature review was conducted on the conceptual frameworks that have been issued by the FASB, TASC, TCAEW, CTCA and the AARF. This was done so as to ensure that OPEB do in fact meet the definitions of liabilities and the recognition criteria as contained in the various frameworks. The exposure drafts and accounting standard issued by these accounting bodies were then considered so as to determine whether they were in conformity with the conceptual frameworks upon which they are based and to highlight any differences between the accounting treatments and disclosures in the various countries.
Bunin, J. Christopher. "A Study of the Relationship Between Current Event Knowledge and the Ability to Construct a Mental Map of the World." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/31030.
Повний текст джерелаMaster of Science
Kňava, Miroslav. "Vyjadřování nejistoty výsledku zkoušky." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229157.
Повний текст джерелаSchulz, Fawn M. "A critical discourse analysis of current composition theory use in IRA/NCTE standards for the English language arts, Ohio middle school English language arts standards and Ohio state writing assessments." University of Findlay / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=findlay1595859435945569.
Повний текст джерелаPoláková, Simona. "Příprava perovskitových solárních článků se standardní n-i-p strukturou a jejich optimalizace." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444539.
Повний текст джерелаBotha, Johanna Catharina. "Rapid sequence intubation: a survey of current practice in the South African pre-hospital setting." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32615.
Повний текст джерелаRocha, Raquel Mafra. "Fuel hedging e o impacto cambial : uma análise sobre os custos operacionais das companhias aéreas IAG e Finnair." Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/20107.
Повний текст джерелаA indústria aérea tem se deparado com a crescente volatilidade que tem existido no mercado do petróleo, uma vez que afeta os seus custos, tendo o combustível um peso de cerca de 30% dos custos operacionais da indústria. Esta situação leva ao uso de várias estratégias de gestão do risco do combustível por parte das companhias aéreas, com o objetivo de redução dos custos do combustível e eliminação da volatilidade dos preços de mercado. Face a situação atual nos mercados, este trabalho visa analisar os custos operacionais de duas companhias aéreas, a IAG e a Finnair. Tem o objetivo de estudar a evolução das receitas e dos custos que as organizações incorreram com as atuais estratégias de hedging do combustível e da taxa de câmbio para assim poder comparar os resultados obtidos pelas diferentes estratégias utilizadas e identificar qual das duas foi a mais eficiente. Iniciamos o estudo através de uma análise da estatística descritiva dos custos e receitas operacionais de cada empresa, recorrendo a medidas standard da aviação. Posteriormente, recorremos a regressões lineares para estudar o impacto do preço do petróleo e como o câmbio interfere no custo unitário do combustível, utilizando variáveis de controlo nas regressões.
The Aviation industry as struggled against the increased volatility that exists in the oil market, affecting its costs, with the fuel weighing 30% in the industries operational costs. This situation leads to the adoption of several risk management strategies for fuel by aviation companies with the goal of fuel cost reduction and thus mitigating the volatility in market prices. In light of current market situation, this work aims to study the operational costs of two airlines, IAG and Finnair, the goal is to check the evolution of their costs an revenues against their hedging strategies for both fuel and currency exchange and thus comparing results achieved by both airlines and find the most efficient one. The study began with a statistical analysis of operational costs and revenue for both entities using standard aviation metrics and later integrating linear regressions to study the impact of oil (price) and currency exchange rate in the cost of fuel, control variables were also used.
info:eu-repo/semantics/publishedVersion