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Добірка наукової літератури з теми "CRPS-1"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "CRPS-1"

Vas, Lakshmi. "Complex Regional Pain Syndrome-Type 1 Presenting as deQuervain’s Stenosing Tenosynovitis." Pain Physician 1;19, no. 1;1 (January 14, 2016): E227—E234. http://dx.doi.org/10.36076/ppj/2016.19.e227.

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Aim: To report the presentation of complex regional pain syndrome-1 (CRPS-1) as deQuervain’s stenosing tenosynovitis (DQST). Case report: A 24-year-old woman presented with 3-year history of clinical diagnostic criteria (CDC) of CRPS-1. Conservative and surgical treatment for this as DQST had failed to relieve her. We diagnosed the problem as CRPS-1with CDC as inflammatory manifestations of a mechanical tendinoses of all her 5 digital tendons caused by movement of the fingers and hand tethered by agonist (flexor)/ antagonist (extensor) muscles in co-contraction. Ultrasound guided dry needling (USGDN) relaxed the muscles, replacing the abnormal agonist/antagonist co-contraction with normal agonist/antagonist coordination. Resolution of tendinoses reversed the inflammation causing the CDC. Six months later she leads normal personal and professional life, with reduction of scores of painDetect (from 21 to 5), Patient Health Questionnaire (from 13 to 4), Disability of arm, shoulder and hand from 70.8 to 25 and reversal of muscle abnormality characteristic of CRPS1 on Musculoskeletal Ultrasonography (MSKUSG). Conclusion: We believe the primary pathology of CRPS-1 to be co-contraction of agonist (flexor)/antagonist(extensor) muscles of digits resulting in tendinoses akin to DQST. CDC of CRPS are actually inflammatory manifestations of tendinoses amenable to reversal by USGDN which also addresses the disability, a hallmark of CRPS. Key words: Complex regional pain syndrome-1 (CRPS-1), deQuervain’s stenosing tenosynovitis (DQST), neuropathy, co-contraction, dry needling (DN), ultrasound guided dry needling (USGDN), musculoskeletal ultrasonography (MSKUSG)

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Kalita, Jayantee. "Long-term Prednisolone in Post-stroke Complex Regional Pain Syndrome." Pain Physician 8;19, no. 8;11 (November 14, 2016): 565–74. http://dx.doi.org/10.36076/ppj/2016.19.565.

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Background: There is no study on the long-term use of prednisolone in post-stroke complex regional pain syndrome-1 (CRPS1). Objective: To evaluate the efficacy and safety of long-term low dose prednisolone in post-stroke CRPS-I. Study Design: Open-labeled randomized controlled trial. Setting: Tertiary care teaching institute. Methods: Seventy-seven out of 396 (19.4%) patients with stroke had CRPS-1 and 58 met the inclusion criteria. Their clinical details and CRPS, Visual Analogue Scale (VAS), modified Rankin Scale (mRS), and Barthel Index (BI) scores were noted. The patients were prescribed 40 mg prednisolone for 2 weeks followed by tapering in the next 2 weeks. Patients who responded were randomly assigned prednisolone 10 mg daily (group I) or no prednisolone (group II). They were followed up for the first and second month of randomization and their CRPS, VAS, mRS, and BI scores were noted. The primary outcome was improvement in CRPS score and secondary outcomes were VAS, mRS, BI scores, and severe adverse events (SAE). Results: Fifty-six of fifty-eight (96.5%) patients responded to the initial high dose prednisolone and 26 each were assigned group I and group II treatment. Group I patients had further improvement in CRPS score. Fifty percent of patients in group II had deterioration at one month and needed reinstitution of prednisolone; following which 77% of them improved in the next month. The improvement in CRPS score paralleled the VAS score but not mRS and BI scores in the first and second months in group I compared to group II. There was no SAE necessitating withdrawal of prednisolone. Limitation: The design of the study is not double blind. Conclusion: In post-stroke CRPS-I, continuation of low dose prednisolone for 2 months is safe and effective. Key words: Shoulder hand syndrome, CRPS, corticosteroid, prednisolone, stroke, Visual Analogue Scale

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Barth, Robert J., and Tom W. Bohr. "Diagnostic Conceptualization for CRPS-1: Challenges in the IASP's Diagnostic Conceptualization for CRPS-1 (Formerly Conceptualized as RSD)." Guides Newsletter 11, no. 1 (January 1, 2006): 4–8. http://dx.doi.org/10.1001/amaguidesnewsletters.2006.janfeb02.

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Abstract Complex regional pain syndrome-type 1 (CRPS-1) is a problematic diagnosis of a characteristic burning pain that is present without stimulation or movement, occurs beyond the territory of a single peripheral nerve, and is disproportionate to the inciting event. This article highlights some challenging aspects of the diagnostic formulation for CRPS-1 by the International Association for the Study of Pain (IASP) and provides recommendations to address the issues. First, the terminology, CRPS-1, was created specifically to replace the previous term, “reflex sympathetic dystrophy.” Unfortunately, no gold standard diagnostic tests exist for CRPS-1, and the concept itself has a long and continuing history of controversy, not the least factor of which is the lack of reliable diagnostic schemes. Next, IASP's criteria for CRPS-1 do not standardize the diagnostic process and depart from epidemiologic guidelines, particularly regarding continuing pain, allodynia, or hyperalgesia disproportionate to any inciting event. Further, the IASP protocol overlaps diagnostic criteria for somatoform disorders, eg, those in the American Psychiatric Association's diagnostic manual, DSM-IV-TR. Finally, according to the IASP protocol, the majority of CRPS-1 patients present with symptoms that are indistinguishable from those in the DSM-IV-TR guidelines, and the majority of CRPS-1 cases are indistinguishable from the formal definition of malingering.

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Bernateck, M. "Anti-TNF-alpha-Therapie bei anderen Indikationen." Arthritis und Rheuma 29, no. 04 (2009): 223–29. http://dx.doi.org/10.1055/s-0037-1620168.

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ZusammenfassungDas Komplexe Regionale Schmerzsyndrom (CRPS) ist eine häufige Komplikation nach Traumen oder elektiven Eingriffen zumeist an der oberen Extremität mit einer Prävalenz von etwa 30 pro 100 000. Prospektive Studien von Patienten mit distaler Radiusfraktur ermittel-ten eine Inzidenz von mehr als 20 Prozent dieser Komplikation. Aktuell unterscheiden die Diagnose-Kriterien zwischen CRPS ohne (CRPS Typ 1) und CRPS mit Nervenläsion (CRPS Typ 2). Zytokine, wie z. B. Tumor-Nekrose-Faktor alpha (TNF-alpha) scheinen eine wichtige Rolle bei der Mediation von mechanischer Hyperalgesie und der Ödembildung in der akuten Phase des CRPS Typ 1 zu spielen. Die Erkenntnis dieser Zusammenhänge führte zu ersten erfolgreichen Einsätzen von Anti-TNF-alpha-Inhibitoren bei Patienten mit CRPS Typ 1.

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Tuinhout, Mirjam, and Jan Willem. "Multidisciplinaire Richtlijn CRPS-type 1." PodoSophia 23, no. 3 (May 2015): 18–20. http://dx.doi.org/10.1007/s12481-015-0051-z.

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Meier, Budak, and Brunner. "Komplexes regionales Schmerzsyndrom Typ 1 (CRPS 1)." Praxis 100, no. 4 (February 1, 2011): 191–200. http://dx.doi.org/10.1024/1661-8157/a000461.

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Devos, A., F. Claessens, P. Alen, J. Winderickx, W. Heyns, W. Rombauts, and B. Peeters. "Identification of a Functional Androgen-Response Element in the Exon 1-Coding Sequence of the Cystatin-Related Protein Gene crp2." Molecular Endocrinology 11, no. 8 (July 1, 1997): 1033–43. http://dx.doi.org/10.1210/mend.11.8.9961.

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Abstract Two hormone-responsive segments, one in the region of the promoter and one in intron 1, are identified in two homologous androgen-regulated and differentially expressed rat genes encoding the cystatin-related proteins (CRPs). Footprint analysis with the androgen receptor (AR) DNA-binding domain on the promoter-containing fragments reveals an AR-binding site downstream of the transcription start point in the crp2 gene (ARBSd/crp2,+ 40/+63). It displays an androgen response element-like sequence motif 5′-AGAAGAaaaTGTACA-3′ and overlaps with the ATG translation start codon. A double-stranded oligonucleotide containing this sequence forms a DNA-protein complex with the full-length AR synthesized by vaccinia, as seen in band shift assays. Additional AR-binding sites, ARBSu/crp1 and ARBSu/crp2, occur 5′ upstream of the transcription start point and are located at an identical position (−142/−120) in crp1 and crp2. The AR affinity for these two slightly different sequence motifs is relatively weak. The biological function of all three AR-binding sites as transcription control elements has been studied. The ARBSd/crp2 element clearly shows androgen-response element characteristics. The contribution of the common upstream element to the androgen-dependent control of reporter gene transcription is less clear. The transcription of a reporter gene construct containing the crp2 footprint fragment crp2F (−273/+88) is hormonally regulated as determined by transfection into the human breast cancer cell line T-47D. Androgens, but also glucocorticoids, efficiently stimulate steroid-dependent transcription of the chloramphenicol acetyltransferase gene. Mutation of the 5′-TGTACA-3′ sequence in ARBSd/crp2 destroys the AR binding and abolishes the androgen-dependent synthesis of chloramphenicol acetyltransferase. A large fragment derived from intron 1 of the crp1 and crp2 gene can also provide the androgen-dependent transcription of chimeric constructs in T-47D cells. However, the induction measured is less than the one observed with crp2F (−273/+88), and this activity seems to reside in several subfragments that each display a low but consistent androgen responsiveness.

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PUCHALSKI, P., and A. ZYLUK. "Complex Regional Pain Syndrome Type 1 after Fractures of the Distal Radius: A Prospective Study of the Role of Psychological Factors." Journal of Hand Surgery 30, no. 6 (December 2005): 574–80. http://dx.doi.org/10.1016/j.jhsb.2005.06.023.

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A prospective study was designed to investigate the question “Do patients who develop Complex Regional Pain Syndrome Type 1 (CRPS Type 1) after fracture of the distal radius display different psychological behaviour patterns and/or are more depressive than those who recover uneventfully after this fracture?” Sixty-two patients of mean age 56 years with displaced distal radius fractures were operated on by closed reduction and percutaneous fixation with K-wires. All these patients were examined psychologically on the day after the operation. A series of standardized, self-administered questionnaires was used to assess personality and depression. Fifty of the 62 patients were reassessed at 2 months for symptoms and signs of CRPS Type 1 and a diagnosis of this condition made on clinical grounds. Nine patients (18%) were diagnosed as having CRPS Type 1. There were no significant differences in scores on any of the personality and depression scales between CRPS Type 1 and non-CRPS Type 1 patients. Therefore, patients who eventually developed CRPS Type 1 after radial forearm fracture had neither a unique psychological pattern nor displayed more symptoms of depression than those who recovered uneventfully.

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van Eijs, Frank, José Geurts, Maarten van Kleef, Catharina G. Faber, Roberto S. Perez, Alfons G. H. Kessels, and Jan Van Zundert. "Predictors of Pain Relieving Response to Sympathetic Blockade in Complex Regional Pain Syndrome Type 1." Anesthesiology 116, no. 1 (January 1, 2012): 113–21. http://dx.doi.org/10.1097/aln.0b013e31823da45f.

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Background Sympathetic blockade with local anesthetics is used frequently in the management of complex regional pain syndrome type 1(CRPS-1), with variable degrees of success in pain relief. The current study investigated which signs or symptoms of CRPS-1 could be predictive of outcome. The incidence of side effects and complications of sympathetic blockade also were determined prospectively. Methods A prospective observational study was done of 49 patients with CRPS-1 in one extremity only and for less than 1-yr duration who had severe pain and persistent functional impairment with no response to standard treatment with medication and physical therapy. Results Fifteen (31%) patients had good or moderate response. The response rate was not different in patient groups with cold or warm type CRPS-1 or in those with more or less than 1.5°C differential increase in skin temperature after sympathetic blockade. Allodynia and hypoesthesia were negative predictors for treatment success in CRPS-1. There were no symptoms or signs of CRPS-1 that positively predicted treatment success. A majority of patients (84%) experienced transient side effects such as headache, dysphagia, increased pain, backache, nausea, blurred vision, groin pain, hoarseness, and hematoma at the puncture site. No major complications were reported. Conclusions The presence of allodynia and hypoesthesia are negative predictors for treatment success. The selection of sympathetic blockade as treatment for CRPS-1 should be balanced carefully between potential success and side effect ratio. The procedure is as likely to cause a transient increase in pain as a decrease in pain. Patients should be informed accordingly.

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Helyes, Zsuzsanna, Valéria Tékus, Nikolett Szentes, Krisztina Pohóczky, Bálint Botz, Tamás Kiss, Ágnes Kemény, et al. "Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms." Proceedings of the National Academy of Sciences 116, no. 26 (June 10, 2019): 13067–76. http://dx.doi.org/10.1073/pnas.1820168116.

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Neuroimmune interactions may contribute to severe pain and regional inflammatory and autonomic signs in complex regional pain syndrome (CRPS), a posttraumatic pain disorder. Here, we investigated peripheral and central immune mechanisms in a translational passive transfer trauma mouse model of CRPS. Small plantar skin–muscle incision was performed in female C57BL/6 mice treated daily with purified serum immunoglobulin G (IgG) from patients with longstanding CRPS or healthy volunteers followed by assessment of paw edema, hyperalgesia, inflammation, and central glial activation. CRPS IgG significantly increased and prolonged swelling and induced stable hyperalgesia of the incised paw compared with IgG from healthy controls. After a short-lasting paw inflammatory response in all groups, CRPS IgG-injected mice displayed sustained, profound microglia and astrocyte activation in the dorsal horn of the spinal cord and pain-related brain regions, indicating central sensitization. Genetic deletion of interleukin-1 (IL-1) using IL-1αβ knockout (KO) mice and perioperative IL-1 receptor type 1 (IL-1R1) blockade with the drug anakinra, but not treatment with the glucocorticoid prednisolone, prevented these changes. Anakinra treatment also reversed the established sensitization phenotype when initiated 8 days after incision. Furthermore, with the generation of an IL-1β floxed(fl/fl)mouse line, we demonstrated that CRPS IgG-induced changes are in part mediated by microglia-derived IL-1β, suggesting that both peripheral and central inflammatory mechanisms contribute to the transferred disease phenotype. These results indicate that persistent CRPS is often contributed to by autoantibodies and highlight a potential therapeutic use for clinically licensed antagonists, such as anakinra, to prevent or treat CRPS via blocking IL-1 actions.

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Більше джерел

Дисертації з теми "CRPS-1"

Johannesson, Caroline. "Bakomliggande historia av stress och psykiatrisk komorbiditet hos barn och ungdomar med CRPS typ-1." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68271.

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Bakgrund: Komplext regionalt smärtsyndrom (Complex Regional Pain Syndrome, CRPS) är ettrelativt ovanligt smärttillstånd. CRPSkan drabba såväl vuxna som barn och ungdomar, men de bakomliggande uppkomstmekanismerna är i dagsläget fortfarande okända.Kombinationen av svåra kroniska smärtor med karaktäristiska autonoma,sensoriska, trofiska och motoriska abnormaliteter kan i många fall leda till en svår invalidisering. Syfte: Syftet med denna studien är att kartlägga förekomsten av en bakomliggande historia av stress,samt psykiatrisk komorbiditet hos barn och ungdomar med CRPS typ-1. Vi vill även belysaviktiga faktorer som kan påverka utfallet och prognosen hos dessa patienter. Metod: En retrospektiv journalstudie där 78 barn och ungdomar inkluderades. Samtliga patienter har varit i åldrarna mellan 8-18 år och har diagnostiseratsmed CRPS typ-1. För bedömning av bakomliggande historia av stress har ett semi-strukturerat anamnesformulär använts. Bedömning avseende psykiatrisk komorbiditet har skett genom en psykiatrisk screeningutförd av en psykolog. Resultat: Av alla patienter hade 96% en bakomliggande historia av stress. Avseende enskilda stressorer fannvimot vad vi förväntat, att antalet stressorer snarast verkar vararelaterat till ett bättre utfall. Dock förekommerhär en stor osäkerhet med anledning av ett stort bortfall.Psykiatrisk komorbiditet förekommer hos 62%av patienterna. Det förekom även signifikanta skillnader mellan enskilda psykiatriskaåkommor och utfallet. Slutligen sågs signifikanta skillnader avseende kön, duration, NRS, spridning och åldersfördelning korrelerat till utfallet. Slutsats: Bakomliggande historia av stress utgör en predisponerande faktor för utvecklingen av CRPS typ-1.Psykiatrisk komorbiditet förekommer i en hög utsträckning och dessa patienter har signifikant svårare för att bli smärtfria.Flickor drabbasi en betydligt högre grad av CRPS typ-1 än pojkar och har svårare för att bli smärtfria. Inga patienter över 15 århar i denna studieblivit smärtfria. Längre duration, högre självskattning av NRS och spridning av tillståndet,är alla faktorer som ledertill en minskad smärtfrihet hosdessa patienter.

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Lemper, Cassandra [Verfasser]. "Mechanismus des sympathisch unterhaltenen Schmerzes bei CRPS - Korrelation zur Expression von alpha-1 Adrenozeptoren in der Haut / Cassandra Lemper." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1240831951/34.

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Kennedy, Amber L. "Pedagogical considerations for a culturally responsive reading program for Indigenous students: Reflections from a critical participatory action research study." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/225973/1/Amber_Kennedy_Thesis.pdf.

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Active student engagement in reading is a major concern of many state, national and international governments. Aboriginal and Torres Strait Islander students on average are well behind Australian standards, due to many factors, including a lack of early reading success. This study investigated what constitutes a culturally responsive reading program for Indigenous children from a critical participatory action research perspective. Culturally responsive pedagogical practices, together with the support of a critical friend with knowledge of local language and culture, contributed to student reading gains (between one and four reading levels in the 5-week data collection period).

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Yang, Jie. "Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1." Doctoral thesis, Uppsala universitet, Institutionen för kemi - BMC, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330489.

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In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. The concept was applied to 2-oxo-1,2-dihydroquinoline-8-carboxylic acid (DQ) and acetazolamide (AZM) for development of high affinity binders targeting human C-reactive protein (CRP) and human carbonic anhydrase (HCA) II and IX respectively. In addition, peptididic macrocycles were developed as inhibitors of lysine specific demethylase 1 (LSD1). CRP is a well-known biomarker of inflammation in humans and binders recognizing it are therefore of large interest as medical diagnostics. Until now, phosphocholine (PCh) and derivatives are the only known small molecule binders for CRP, but they have low μM affinity and bind CRP in a Ca2+ dependent manner. The small molecule DQ was designed as a CRP binder that is structurally unrelated to PCh. Its polypeptide conjugate, 4-C25l22-DQ, was demonstrated as a strong, Ca2+ independent binder for CRP, and had an affinity approximately three orders of magnitude higher than DQ itself. HCA IX is a protein that is interesting for diagnosis of cancer. AZM is a small molecule inhibitor of HCAs with a dissociation constant of 38 nM for HCA II and 3 nM for HCA IX. Interestingly, polypeptide conjugate 4-C10L17-AZM displayed stronger binding to both HCA II (KD 4 nM) and HCA IX (KD 90 pM). This result provided evidence that the binder concept can be applied also for small molecules which already have high affinity for their protein receptors. LSD1 is an enzyme that regulates the methylation of Lys 4 of histone 3 via a PPI-like interaction and which is of therapeutic interest in certain cancers. Based on the structures of two peptidic ligands bound to LSD1, we sequentially prepared truncated, mono-substituted and macroyclic peptides in order to develop reversible inhibitors of LSD1. Some stapled cyclic peptides bound to LSD1 with 10-fold higher affinity than the corresponding linear parent peptide. Changing the staple into a lactam further improved the binding potency and the best lactams inhibited the enzymatic activity of LSD1 at low μM Ki values.

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Hsieh, Chen-Lin. "The Pro-cancer Function of Soluble Guanylate Cyclase Alpha-1 in Prostate Cancer Progression." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1278952517.

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Schölin, Anna. "Diabetes in Young Adults : Remission, β-cell function and markers of inflammation". Doctoral thesis, Uppsala University, Department of Medical Sciences, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3464.

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Type 1 diabetes is caused by immuno-mediated β-cell destruction leading to insulin deficiency and hyperglycaemia. The decline in β-cell function and the clinical course after diagnosis vary. Whether the process of destruction of the β-cells is associated with markers of a non-specific inflammatory response is unknown. The aims of these studies were to identify factors of importance for clinical remission (low insulin need and normoglycaemia) and long-term β-cell function and estimate the degree of non-inflammatory response in type 1 diabetes in young adults. Clinical remission and β-cell function eight years after diagnosis were assessed and related to clinical, biochemical and immunological variables at diagnosis, including islet autoantibodies [ICA, GADA, IA-2A]. Markers of low-grade inflammation in plasma [CRP and IL-6] were estimated and the concentrations were related β-cell function [plasma C-peptide], glycaemic control and autoimmunity at diagnosis and the first year thereafter. The results showed that clinical remission occurred in about half of the patients with newly diagnosed type 1 diabetes. Preserved β-cell function eight years after diagnosis was observed in 16% of the patients classified at diagnosis as having autoimmune type 1 diabetes. Duration of remission was dependent on BMI, degree of metabolic derangement and presence of GADA at diagnosis. BMI at diagnosis was also of importance for preserved β-cell function after eight years of the disease, as were the amount of islet antibodies and presence of ICA. Elevated CRP levels were noted in the majority of cases at diagnosis and both CRP and IL-6 concentrations were stable the first year after clinical diagnosis. High concentrations of CRP and IL-6 did not relate to β-cell destruction or the degree of autoimmunity. CRP concentrations were higher in islet antibody negative than in positive patients. CRP also correlated positively to BMI, C-peptide at 12 months and to increasing HbA1c between six and 12 months. In general, females had shorter remissions, lower concentrations of serum bicarbonate and higher levels and prevalence of GADA at diagnosis, compared to males. Females also had higher HbA1c and CRP values the first year after diagnosis. In summary, BMI at diagnosis is a strong predictor of duration of remission and preservation of β-cell function. Elevated CRP concentrations are correlated to factors linked rather to insulin resistance than to β-cell destruction. Females appear to have a more acute onset and a more severe course of the disease than males.

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Young, Duprane Pedaci. "From In Vitro to In Vivo: Control of C-Reactive Protein Gene Expression by Cytokines." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1201365244.

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Foster, Wednesday Douglas Tommy C. Risser Jan Mary Hale Moyé Lemuel A. "The association of HSV 1 and 2 with atherosclerosis defined by CRP level /." 2007. http://proquest.umi.com.www5.sph.uth.tmc.edu:2048/pqdweb?did=1428839641&sid=1&Fmt=2&clientId=92&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Texas Health Science Center at Houston, School of Public Health, 2007.
"December 2007." Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7222. Adviser: Zuber D. Mulla. Includes bibliographical references (leaves 157-169).

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Li, Ling. "Regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) : relevance to diabetic vasculopathy." Thèse, 2004. http://hdl.handle.net/1866/14207.

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CHU, YI-CHING, and 朱怡靜. "KRT1 as a CRP Receptor with CD32 and LOX-1 Mediates the Effect of CRP/OxLDL on Functions of Human Aortic Endothelial Cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/26528436436375327204.

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博士
國立中正大學
化學工程研究所
104
Atherosclerosis is a chronic inflammatory disease of the arteries. C-reactive protein (CRP) and oxidized low-density lipoprotein (oxLDL) play a significant role in the pro-inflammatory response observed in various types of vascular disease. CRP is capable of binding to various molecules including oxLDL and may bind to the receptor other than CD32 and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). However, how CRP/oxLDL complexes are formed, as well as their effect and corresponding receptors on endothelial cells, remains unknown. Here, we identified keratin 1 (KRT1) on endothelial cells as a novel protein for CRP binding by affinity chromatography and mass spectrometry. The interaction between KRT1 and CRP was also confirmed by the antibody blockade of KRT1 that decreased the CRP uptake and CRP-mediated reduction in nitric oxide (NO) release in human aortic endothelial cells (HAECs). Similar to CD32 and LOX-1 induced by oxdative stress, KRT1 was induced by CRP. Additionally, an increased KRT1 expression by transfection of plasmid pcDNA3.1-KRT1 enhanced but a reduced KRT1 expression by KRT1 small hairpin RNAs reversed the CRP antagonism in NO release. On the other hand, we found that the induction of NO release by CRP and oxLDL co-incubates was dependent on the ratio of CRP and oxLDL. Specifically, the concentration ratio of ~1:20 (CRP/oxLDL-1:20) resulted in the greatest inhibition of endothelial NO secretion. Pretreatment of neutralizing antibodies for CD32, LOX-1, or KRT1 abolished the effect of CRP/oxLDL-1:20 on NO production. Furthermore, we found that CD32, LOX-1, and KRT1 mediated the cellular uptake of CRP/oxLDL complexes, in which LOX-1 co-localized with KRT1, but not CD32. These results provide a novel mechanism by which the multifaceted effects of CRP/oxLDL complexes on endothelial cells can be targeted for the treatment of vasculature diseases.

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Книги з теми "CRPS-1"

Riley, Bobbie, and Navil Sethna. Pediatric Complex Regional Pain Syndrome Type 1. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0054.

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Complex regional pain syndrome type 1 (CRPS-1) is a condition that affects adolescents and children under the age of 7. It usually follows minor injury and rarely occurs spontaneously. The pain is usually out of proportion to the inciting injury. Pain, allodynia, and/or hyperalgesia are severe enough to inhibit use of the affected limb. Delay in diagnosis and self and/or iatrogenic immobilization of the affected limb may lead to worsening pain, skin hypersensitivity and discoloration, swelling, and vasomotor and dystrophic abnormalities. The diagnosis of CRPS-1 and 2 is based on symptoms. There are no diagnostic tests that can confirm the presence or absence of CRPS-1. CRPS-2 diagnosis is established by nerve conduction test and electromyography. Clinical practice neuropathic guidelines are most effective for CRPS-2 treatment. Pharmacological and interventional treatment options for CRPS-1 are limited and usually ineffective because the underlying mechanism(s) are yet to be determined.

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Walters, Jenna L. Complex Regional Pain Syndrome. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190217518.003.0025.

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Complex regional pain syndrome (CRPS) is a neuropathic pain condition classified as type 1 and type 2. The two classifications are distinguished by the presence of documented nerve injury in CRPS type 2. The symptoms of CRPS, including cold, blue, and painful extremities, are believed to occur from vasoconstriction caused by sympathetic dysfunction. Treatment in CRPS focuses on targeting neuropathic and sympathetically maintained pain. Traditional antineuropathic pain medications include membrane stabilizers and serotonin and norepinephrine reuptake inhibitors. Corticosteroids and nonsteroidals target the inflammatory process present in the initial stages of CRPS. Bone resorption has been treated with calcium-modulating drugs. Interventional therapies include sympathetic blockade of the affected extremity, spinal cord stimulation, and intrathecal drug delivery. All these therapies have been implemented in an effort to facilitate functional restoration of the affected limb. Physical and occupational therapies have demonstrated some of the most significant improvements in pain, mobility, and function.

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Gasoline/Methanol Mixtures for Materials Testing (Sae Cooperative Research Report September 1990, Crp-1). Society of Automotive Engineers, 1992.

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Gasoline/Methanol Mixtures for Materials Testing (Sae Cooperative Research Report September 1990, Crp-1). Society of Automotive Engineers Inc, 1992.

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Twisk, Jos, and Isabel Ferreira. Physical activity, physical fitness, and cardiovascular health. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199232482.003.0025.

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The incidence of morbidity and mortality related to CVD is rather low in a paediatric population. Studies investigating the relationship between physical activity, physical fitness, and cardiovascular health in children and adolescents are therefore mostly limited to CVD risk factors as outcome measures. For this reason, this chapter will focus on the association of physical activity and physical fitness with CVD risk factors in children and adolescents. These risk factors can be divided into the so-called traditional CVD risk factors; that is, lipoproteins [total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG)], blood pressure, body fatness, and diabetes, and ‘new’ CVD risk factors; that is, other lipoproteins [lipoprotein(a) (Lp(a)), apolipoprotein (apo)B, and apoA-1], coagulation and inflammation markers [fibrinogen, C-reactive protein (CRP)], homocysteine, and heart rate variability.

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Частини книг з теми "CRPS-1"

Krane, Elliot. "CRPS-1 in Children." In Encyclopedia of Pain, 818–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28753-4_944.

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van Nugteren, Koos. "Addendum: Chronisch Regionaal Pijn Syndroom Chronisch Regionaal Pijn Syndroom type 1 CRPS-1 type 1." In Orthopedische casuïstiek, 746–48. Houten: Bohn Stafleu van Loghum, 2010. http://dx.doi.org/10.1007/978-90-313-8803-5_229.

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Birklein, Frank. "Komplexes regionales Schmerzsyndrom (CRPS)." In Praktische Schmerzmedizin, 1–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-642-54670-9_43-1.

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Suresh, Santhanam, and Antoun Nader. "Complex Regional Pain Syndrome (CRPS)." In Handbook of Pediatric Chronic Pain, 265–71. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-0350-1_16.

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Chang, Richard G., and Houman Danesh. "Complex Regional Pain Syndrome (CRPS)." In Pain Management and Palliative Care, 171–77. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2462-2_24.

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Donahue, Dean M. "Surgical Techniques: Cervical Sympathectomy in the Treatment of CRPS/RSD." In Thoracic Outlet Syndrome, 225–29. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4366-6_31.

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Tolba, Reda. "Complex Regional Pain Syndrome (CRPS): Type I and Type II." In Treatment of Chronic Pain Conditions, 249–50. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6976-0_72.

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Nepali, Prerna R., and Adriana Haimovitz-Friedman. "Chemotherapeutic Agents-Induced Ceramide-Rich Platforms (CRPs) in Endothelial Cells and Their Modulation." In Methods in Molecular Biology, 215–21. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0814-2_12.

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Grönhagen-Riska, Carola, Anna-Maija Teppo, Eero Honkanen, and Risto Ikäheimo. "Alpha-1-Antitrypsin, CRP and Interleukin-6 in ANCA-positive Vasculitis." In Advances in Experimental Medicine and Biology, 337–40. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4757-9182-2_55.

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Yoshizaki, Kazuyuki. "Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases." In Advances in Experimental Medicine and Biology, 141–50. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6612-4_15.

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Тези доповідей конференцій з теми "CRPS-1"

Kang, Ki-Sig. "IAEA Coordinated Research Projects on Master Curve Technology: An Overview." In ASME 2007 Pressure Vessels and Piping Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/pvp2007-26351.

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The IAEA has sponsored a series of Coordinated Research Projects (CRPs) that have led to a focus on reactor pressure vessel (RPV) structural integrity. In the previous CRP on the application of the Master Curve (MC), three key areas were identified to need further works. These three tasks are: (1) test specimen bias, constraint, and geometry effects on the measurement and application of To values; (2) effects of loading rate up to impact loading conditions on To; and (3) potential changes in the shape of the MC for highly embrittled RPV materials. These three areas are focused on the new CRP (here below CRP-8). A new CRP is follow-on to previous successful CRPs on resolving technical issues associated with application of the MC approach. Overall objectives of CRP-8 include: 1) Better quantification of fracture toughness issues related to testing surveillance specimens for application to RPV integrity assessment, and 2) Development of approaches for addressing MC technical issues in integrity evaluation of operating RPVs. 15 organizations from 11 countries participate in the CRP and the final report will be issued in the end of 2008.

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Zhou, Yong, Xiaobin Yi, Wenxin Xing, Song Hu, Konstantin I. Maslov, and Lihong V. Wang. "Photoacoustic microscopy of complex regional pain syndrome type I (CRPS-1) after stellate ganglion blocks in vivo." In SPIE BiOS, edited by Alexander A. Oraevsky and Lihong V. Wang. SPIE, 2015. http://dx.doi.org/10.1117/12.2076691.

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Crotti, Chiara, Maria Manara, Francesca Zucchi, Davide Gatti, Maurizio Rossini, and Massimo Varenna. "THU0557 NERVE GROWTH FACTOR, SCLEROSTIN AND DKK-1 SERUM LEVELS IN COMPLEX REGIONAL PAIN SYNDROME1 (CRPS-1): A PILOT STUDY ON 41 PATIENTS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.4855.

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Nanstad, Randy K., and Marc Scibetta. "IAEA Coordinated Research Project on Master Curve Approach to Monitor Fracture Toughness of RPV Steels: Effects of Bias, Constraint, and Geometry." In ASME 2007 Pressure Vessels and Piping Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/pvp2007-26231.

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There is strong interest from the nuclear industry to use the precracked Charpy single-edge notched bend, SE(B), specimen (PCVN) to enable determination of the reference temperature, T0, with reactor pressure vessel surveillance specimens. Unfortunately, for many different ferritic steels, tests with the PCVN specimen (10×10×55 mm) have resulted in T0 temperatures up to 25°C lower than T0 values obtained using data from 25-mm thick compact specimens [1TC(T)]. This difference in T0 reference temperature has often been designated a specimen bias effect, and the primary focus for explaining this effect is loss of constraint in the PCVN specimen. The International Atomic Energy Agency has developed a three-part coordinated research project (CRP) to evaluate various issues associated with the fracture toughness Master Curve for application to light-water reactor pressure vessels. One part of the CRP is focused on the issue of test specimen geometry effects, with emphasis on the PCVN bias. Participating organizations for this part of the CRP are performing fracture toughness testing of various steels, including the reference steel JRQ (A533-B-1) often used for IAEA studies, with various types of specimens under various conditions. Additionally, many of the participants are taking part in a round robin exercise on finite element modeling of the PCVN specimen. Some preliminary results from fracture toughness tests are compared with regard to effects of specimen size and type on the reference temperature T0. In agreement with a number of published results, the results do generally show lower values of T0 from the PCVN specimen compared with the compact and larger bend specimens. They also clearly show higher apparent fracture toughness for the shallow crack compared with the deep crack configuration. Moreover, the SE(B) specimens exhibit a tendency for decreasing T0 with decreasing specimen size (thickness and/or remaining ligament). Additionally, as shown in previous CRPs, the results also exhibit a dependence on test temperature. Following completion of all testing, the results will be evaluated relative to existing proposed models with a view towards developing an understanding of the reasons for the observed differences.

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Bellocq, Pablo, Inaki Garmendia, and Vishal Sethi. "Preliminary Design Assessments of Pusher Geared Counter-Rotating Open Rotors: Part II — Impact of Low Pressure System Design on Mission Fuel Burn, Certification Noise and Emissions." In ASME Turbo Expo 2015: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/gt2015-43816.

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In this 2-part publication, the impact of the main low pressure system parameters of a counter rotating Geared Open Rotor (GOR) on mission fuel burn, certification noise and emissions is presented for a 160 PAX medium haul class aircraft. Due to their high propulsive efficiency, GORs have the potential to significantly reduce fuel consumption and emissions relative to conventional high bypass ratio turbofans. However, this novel engine architecture presents many design and operational challenges both at engine and aircraft level. The assessment of the impact of the main low pressure preliminary design parameters of GORs on mission fuel burn, certification noise and emissions is necessary at preliminary design stages in order to identify optimum design regions. These assessments may also aid the development process when compromises need to be performed as a consequence of design, operational or regulatory constraints. Part I of this two-part publication describes the main low pressure (LP) system design choices for a GOR as well as the preliminary design philosophy and simulation framework developed for the assessments. Part II presents the assessment studies. A fixed reference aircraft and mission were used to evaluate the different GOR engine designs. The results are presented in the form of 1-D or 2-D plots in which one or two design parameters are varied at the same time. The changes in mission fuel burn, certification noise and emissions are expressed as differences relative to a baseline design, due to the fact that preliminary design tools were used for the assessments. The main conclusions of the study are: • Increasing spacing between the propellers (from 0.65 to 1.3m) reduces noise significantly (∼6 EPNdB for each certification point) with a relatively small fuel burn penalty (∼0.3–0.5%) • Relative to unclipped designs, 20% clipped CRPs reduce flyover noise by at least 2.5 EPNdB and approach noise by at least 4.5 EPNdB. The corresponding fuel burn penalty is ∼2%. • Sideline and flyover noise can be reduced by increasing the diameter of the CRP and appropriately controlling CRP rotational speeds. Approach noise can be reduced by either reducing the diameters or the rotational speeds of the propellers. • Regardless of clipping, reducing the rotational speed of the rear propeller relative to the forward propeller reduces noise and, to a certain limit, also mission fuel burn. Further reductions in rotational speed would have an adverse effect on fuel burn. • For given rotational speeds of the propellers, the torque ratio of the gearbox is fixed within ±3%.

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Bellocq, Pablo, Vishal Sethi, Stefano Capodanno, Alexis Patin, and Fernando Rodriguez Lucas. "Advanced 0-D Performance Modelling of Counter Rotating Propellers for Multi-Disciplinary Preliminary Design Assessments of Open Rotors." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-27141.

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Due to their high propulsive efficiency, Counter Rotating Open Rotors (CRORs) have the potential to significantly reduce fuel consumption and emissions relative to conventional high bypass ratio turbofans. However, this novel engine architecture presents many design and operational challenges both at engine and aircraft level. The assessment of the impact of the main low pressure preliminary design and control parameters of CRORs on mission fuel burn, certification noise and emissions is necessary at preliminary design stages in order to identify optimum design regions. These assessments may also aid the development process when compromises need to be performed as a consequence of design, operational or regulatory constraints. The required preliminary design simulation tools should ideally be 0-D or 1-D (for computational purposes) and should capture the impact of the independent variation of the main low pressure system design and control variables such as: the number of blades, diameter and rotational speed of each propeller, the spacing between the propellers and the torque ratio of the gearbox or the counter rotating turbine amongst others. From a performance point of view, counter rotating propellers have historically been modelled as single propellers. Such a performance model does not provide the required flexibility for a detailed design and control study. This paper presents a novel 0-D performance model for Counter Rotating Propellers (CRPs) based on the classical low speed performance model for individual propellers and the interactions between them. This model also incorporates a compressibility correction which is applied to both propellers. The proposed model is verified with publicly available wind tunnel test data from NASA. The novel 0-D counter rotating propeller performance model is used to produce a performance model of a geared Open Rotor engine with a 10% clipped propeller. This engine model is first used to study the impact of the control of the propellers on the cruise fuel consumption. Subsequently, the engine performance model is integrated in a multi-disciplinary simulation platform to study the impact of the control of the propellers on the certification noise. The results of this case study show that 1–2% SFC savings at cruise are possible and an optimal control schedule is identified. It is also concluded that significant certification noise reductions are possible through an adequate control of the rotational speeds of the propellers.

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Ha, Su-Ji, Jin-Ho Park, Ju-Young Byun, Young-Deok Ahn, and Min-Gon Kim. "A localized surface plasmon resonance (LSPR) immunosensor for CRP detection using 4-chloro-1-naphtol (4-CN) precipitation." In International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2017, edited by Jaebum Choo and Seung-Han Park. SPIE, 2017. http://dx.doi.org/10.1117/12.2271397.

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Viehrig, Hans-Werner, and Enrico Lucon. "IAEA Coordinated Research Project on Master Curve Approach to Monitor Fracture Toughness of RPV Steels: Effect of Loading Rate." In ASME 2007 Pressure Vessels and Piping Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/pvp2007-26087.

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In the final evaluation for the application of the Master Curve in the IAEA Coordinated Research Project Phase 5 (CRP-5), one of the areas which was identified as needing further work concerned the effects of loading rate on the reference temperature To up to impact loading conditions. This subject represents one of the three topic areas within the current CRP-8. The effect of loading rate can be broken down into two distinct aspects: 1) the effect of loading rate on the Master Curve To values for loading rates within the specified in ASTM E1921-05 for quasi-static loading (0.1–2 MPa√m/s); 2) the effect of loading rate on To values for higher loading rates, including impact conditions using instrumented precracked Charpy (PCC) specimens. The new CRP includes both aspects, but primarily focuses on the second element of loading rate effects, i.e. loading rates above 2 MPa√m/s. These issues are investigated within the topic area #2 of CRP-8 (Loading Rate Effect). The mandatory portion of this topic area required participation in a round-robin exercise (RRE) to validate the application of the Master Curve approach to PCC specimens tested in the ductile-to-brittle transition region using an instrumented pendulum (10 tests per participant on the JRQ material). The current status of the RRE is presented in [1]. The non-mandatory portion of this topic area consists in providing Master Curve data obtained at different loading rates on various RPV steels, in order to assess the loading rate dependence of To and compare it with an empirical model proposed by Wallin. Moreover, additional topics will be addressed, such as: • comparison of results from unloading compliance and monotonic loading in the quasi-static range; • estimation of fracture toughness from Charpy V-notch data; • assessment of crack arrest properties from instrumented Charpy results; • effect of irradiation on the relationship between static and dynamic fracture toughness.

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Drace, Zoran, and Michael I. Ojovan. "Cementitious Materials for Radioactive Waste Management Within IAEA Coordinated Research Project." In ASME 2011 14th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2011. http://dx.doi.org/10.1115/icem2011-59021.

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The IAEA Coordinated Research Project (CRP) on cementitious materials for radioactive waste management was launched in 2007 [1, 2]. The objective of CRP was to investigate the behaviour and performance of cementitious materials used in radioactive waste management system with various purposes and included waste packages, wasteforms and backfills as well as investigation of interactions and interdependencies of these individual elements during long term storage and disposal. The specific research topics considered were: (i) cementitious materials for radioactive waste packaging: including radioactive waste immobilization into a solid waste form, (ii) waste backfilling and containers; (iii) emerging and alternative cementitious systems; (iv) physical-chemical processes occurring during the hydration and ageing of cement matrices and their influence on the cement matrix quality; (v) methods of production of cementitious materials for: immobilization into wasteform, backfills and containers; (vi) conditions envisaged in the disposal environment for packages (physical and chemical conditions, temperature variations, groundwater, radiation fields); (vii) testing and nondestructive monitoring techniques for quality assurance of cementitious materials; (viii) waste acceptance criteria for waste packages, waste forms and backfills; transport, long term storage and disposal requirements; and finally (ix) modelling or simulation of long term behaviours of cementations materials used for packaging, waste immobilization and backfilling, especially in the post-closure phase. The CRP has gathered overall 26 research organizations from 22 Member States aiming to share their research and practices on the use of cementitious materials [2]. The main research outcomes of the CRP were summarized in a summary report currently under preparation to be published by IAEA. The generic topical sections covered by report are: a) conventional cementitious systems; b) novel cementitious materials and technologies; c) testing and waste acceptance criteria; and d) modelling long term behaviour. These themes as well as all contributions of participating organizations were further developed in the individual reports to be presented in the IAEA publication. The CRP facilitated the exchange of information and research co-operation in resolving similar problems between different institutions and contributed towards improving waste management practices, their efficiency and general enhancement of safety.

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Hussein, Ola, Feras Alali, Ala-Eddin Al Moustafa, and Ashraf Khalil. "Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0179.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive scaffolds being investigated for their antitumor activities. Three series of 18 cyclic (tetralone-based) and two acyclic chalcone analogs, in which ring B was either substituted with nitrogen mustard or replaced by pyrrole or pyridine heterocyclic rings, were designed, synthesized and evaluated as potential therapies for CRPC. Compounds were synthesized by Claisen-Schmidt condensation reaction, purified using columnchromatography or recrystallization and characterized by 1H-NMR, 13C-NMR and LC-MS. The compounds' in-vitro cytotoxicity was evaluated against three prostate cancer cell lines (PC3, DU145, and LNCaP). Among the tested compounds, OH14, OH19 and OH22 showed potent antiproliferative activities at low micromolar levels with IC50 values ranging between 4.4 and 10 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule OH19 revealed that it significantly induces apoptosis through upregulation of Bax and downregulation of BCL-2. In addition, OH19 potently inhibits colony formation and reduces cell migration of androgen-independent PCa cell lines (PC3 and DU145). The molecular pathway analysis show that the anticancer activity of OH19 is associated with attenuation in the phosphorylation of Akt and ERK. Furthermore, OH19 inhibits blood vessel formation in the chick chorioallantoic membrane (CAM) model as compared to control. These results indicate that OH19 could serve as a potential promising lead molecule for the treatment of CRPC and thus, further in-vitro and invivo studies are warranted.

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Звіти організацій з теми "CRPS-1"

Hayes, Anne M. Assessment as a Service Not a Place: Transitioning Assessment Centers to School-Based Identification Systems. RTI Press, April 2020. http://dx.doi.org/10.3768/rtipress.2020.op.0064.2004.

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The World Health Organization and World Bank (2011) estimate that there are more than 1 billion people with disabilities in the world. To address this population’s diverse needs, the United Nations drafted their Convention on the Rights of Persons with Disabilities (CRPD) in 2006. Article 24 (Education) of the CRPD requires ratifying countries to develop an inclusive education system to address the educational needs of students with disabilities alongside their peers without disabilities. Despite substantive improvements and movement toward inclusive education, many low- and middle-income countries (LMICs) continue to struggle with accurately identifying and supporting students with disabilities, including knowing how to effectively screen, evaluate, and qualify students for additional services (Hayes, Dombrowski, Shefcyk, & Bulat, 2018a). These challenges stem from the lack of policies, practices, and qualified staff related to screening and identification. As a result, many students with less-apparent disabilities—such as children with learning disabilities—remain unidentified and do not receive the academic supports they need to succeed in school (Friend & Bursuck, 2012). This guide attempts to address the lack of appropriate, useful disability screening and identification systems and services as countries look to educate all students in inclusive settings. Specifically, this guide introduces viable options for screening and identification related to vision, hearing, and learning disabilities in inclusive classrooms in LMICs. It also provides guidance on how LMICs can transition from an assessment-center model toward a school-based identification model that better serves an inclusive education system.

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Fan, Yihua, Xiaoyin Zhao, Xiaoxu He, and Huixin Chen. Efficacy and safety of Chinese herbal compound in the treatment of acute gouty arthritis: A protocol of a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0153.

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Review question / Objective: To evaluate the efficacy and safety of Chinese herbal compound in the treatment of acute gouty arthritis. Eligibility criteria: 1.1.1 Literature type Randomized controlled trials of treating AGA with Chinese herbal compound alone, whether blind or not, was limited to Chinese literature and English literature.1.1.2 SubjectsThe time of onset, gender, and age of patients diagnosed with acute gouty arthritis were not restricted.1.1.3 Intervention measures The treatment group was treated with traditional Chinese medicine compound, which could be proprietary Chinese medicine, self-made prescription or classic prescription, and the dosage form could be traditional decoction, granule or pill, while the control group was treated with non-steroidal anti-inflammatory painkillers, and the frequency, dosage and course of use were not limited.1.1.4 Outcome indicators(1) Main outcome measures: total response rate; (2) Secondary outcome indicators: visual analog scale (VAS), TCM syndrome score, blood uric acid, ESR, CRP, and incidence of adverse reactions.

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