Добірка наукової літератури з теми "Continuous Crystallization System"
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Статті в журналах з теми "Continuous Crystallization System"
TAHARA, Kohei. "Spherical Crystallization for Pharmaceutical Continuous Manufacturing System." Hosokawa Powder Technology Foundation ANNUAL REPORT 25 (2017): 75–78. http://dx.doi.org/10.14356/hptf.15111.
Повний текст джерелаLoren, Bradley P., Michael Wleklinski, Andy Koswara, Kathryn Yammine, Yanyang Hu, Zoltan K. Nagy, David H. Thompson, and R. Graham Cooks. "Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine." Chemical Science 8, no. 6 (2017): 4363–70. http://dx.doi.org/10.1039/c7sc00905d.
Повний текст джерелаYang, Xiaochuan, David Acevedo, Adil Mohammad, Naresh Pavurala, Huiquan Wu, Alex L. Brayton, Ryan A. Shaw, et al. "Risk Considerations on Developing a Continuous Crystallization System for Carbamazepine." Organic Process Research & Development 21, no. 7 (July 8, 2017): 1021–33. http://dx.doi.org/10.1021/acs.oprd.7b00130.
Повний текст джерелаTahara, Kohei, Marcus O’Mahony, and Allan S. Myerson. "Continuous Spherical Crystallization of Albuterol Sulfate with Solvent Recycle System." Crystal Growth & Design 15, no. 10 (September 17, 2015): 5149–56. http://dx.doi.org/10.1021/acs.cgd.5b01159.
Повний текст джерелаChan, V. A., and H. M. Ang. "A laboratory continuous crystallization system for aluminium hydroxide precipitation studies." Journal of Crystal Growth 166, no. 1-4 (September 1996): 1009–14. http://dx.doi.org/10.1016/0022-0248(96)00061-9.
Повний текст джерелаŽáček, Stanislav, and Jaroslav Nývlt. "Continuous Precipitation of Lead Iodide." Collection of Czechoslovak Chemical Communications 59, no. 7 (1994): 1503–10. http://dx.doi.org/10.1135/cccc19941503.
Повний текст джерелаMack, Corin, Johannes Hoffmann, Jan Sefcik, and Joop H. ter Horst. "Phase Diagram Determination and Process Development for Continuous Antisolvent Crystallizations." Crystals 12, no. 8 (August 6, 2022): 1102. http://dx.doi.org/10.3390/cryst12081102.
Повний текст джерелаNordquist, Kyle, Tiffany Kinnibrugh, Kevin Scaab, and Andrew Bond. "Use of enhanced nucleation surfaces in a continuous flow crystallization system." Acta Crystallographica Section A Foundations and Advances 75, a1 (July 20, 2019): a55. http://dx.doi.org/10.1107/s0108767319099446.
Повний текст джерелаCui, Yuqing, Marcus O’Mahony, Juan J. Jaramillo, Torsten Stelzer, and Allan S. Myerson. "Custom-Built Miniature Continuous Crystallization System with Pressure-Driven Suspension Transfer." Organic Process Research & Development 20, no. 7 (June 27, 2016): 1276–82. http://dx.doi.org/10.1021/acs.oprd.6b00113.
Повний текст джерелаLai, Tsai-Ta C., Steven Ferguson, Laura Palmer, Bernhardt L. Trout, and Allan S. Myerson. "Continuous Crystallization and Polymorph Dynamics in the l-Glutamic Acid System." Organic Process Research & Development 18, no. 11 (July 16, 2014): 1382–90. http://dx.doi.org/10.1021/op500171n.
Повний текст джерелаДисертації з теми "Continuous Crystallization System"
Sultana, Mahmooda. "Microfluidic systems for continuous crystallization of small organic molecules." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59879.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
This thesis presents one of the first demonstrations of continuous crystallization in microfluidic devices, and illustrates their use for various applications related to crystallization of small organic molecules. Crystallization is an important process in a number of industries, including specialty chemicals, food, cosmetics, nutraceuticals and, most importantly, pharmaceuticals. Most small molecule pharmaceuticals are isolated in crystalline form, and more than ninety percent of all pharmaceutical products are formulated in particulate, mainly crystalline form. However, crystallization is not a completely understood process. The sensitivity of the process to synthesis conditions gives rise to serious reproducibility issues. The traditional batch crystallizers suffer from non-uniform process conditions across the reactor, and chaotic, poorly controlled mixing of the reagents, often resulting in polydisperse crystal size distribution and impure polymorphs. This makes it difficult to obtain reliable information on the process kinetics that can be used for scale-up, as well as to study the fundamentals of the process. Microfluidic systems offer a unique toolset for crystallization because of well-defined laminar flow profiles, enhanced heat and mass transfer, better control over the contact mode of the reagents, and optical access for in situ characterization. The better control over the synthesis conditions gives rise to the potential for controlling the crystal size, as well as the polymorphic form. In addition, low consumption of reagents makes it an attractive research tool for expensive pharmaceutical compounds. Some of the advantages of microfluidics have been demonstrated for crystallization in micro-batches, but so far not in continuous devices. Continuous crystallization is difficult to achieve in microchannels as uncontrolled nucleation, crystal growth, agglomeration and sedimentation of crystals easily clog the small channels. The interaction of crystals with channel walls may also contribute to channel plugging in these devices. This thesis has developed microfluidic devices for continuous crystallization of small organic molecules for the first time. We have decoupled nucleation and growth, the two key steps of crystallization, using reaction engineering principles, and have developed two separate continuous devices, one for each of these two processes. We have used seeded crystallization and reactor design to achieve controlled growth, as well as to suppress secondary nucleation, agglomeration and sedimentation of crystals. In addition, we have eliminated any significant interaction of crystals with channel walls by controlling the properties of channel surfaces. We have also integrated microscopy and spectroscopy tools with the device for in-situ characterization of crystal size and polymorphic form. We have illustrated the use of these devices to extract growth kinetics data for crystals of various shapes, including high aspect ratio systems such as that with acicular or plate-like habits. The reproducibility and control in our devices have allowed us to elucidate the growth mechanism and fundamentals of the growth process for difficult crystal systems. In addition, we have demonstrated that continuous microfluidic devices offer a unique advantage over the current state-of-the art technology to measure the size, size distribution and growth kinetics of high aspect ratio crystal systems more accurately. Moreover, we have demonstrated the use of microfluidic devices for understanding crystal habit modification in the presence of impurities. We take advantage of the high spatiotemporal resolution of microfluidic devices to study the evolution of crystal habit over time, and to obtain information on the kinetics of habit modification in the presence of different impurities. We have developed an understanding of the habit modification mechanism for alpha glycine in the presence of alpha amino acids. Such information may not only provide insights into impurity-crystal interactions, but also serve as a powerful tool for the design of impurities that can be deliberately added to improve the crystallization process. Furthermore, we have designed and developed a second microfluidic device for continuous supercritical crystallization for the first time. Using supercritical fluid as an antisolvent, we have demonstrated continuous spontaneous nucleation of acetaminophen. We have shown the ability to produce micron-sized crystals, which may be useful for increasing the bioavailability of drugs with lower solubility, as well as for inhalable and highly potent drugs with stringent size requirements. The developed platform can also be used as a high-throughput device for safely screening crystallization conditions in the supercritical domain. We have demonstrated such use by screening the effects of pressure and various solvents on the habit, size and polymorphic form of acetaminophen crystals.
by Mahmooda Sultana.
Ph.D.
Книги з теми "Continuous Crystallization System"
Ducruix, Arnaud, and Richard Giegé, eds. Crystallization of Nucleic Acids and Proteins. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199636792.001.0001.
Повний текст джерелаFuras, Yoni. Educating Palestine. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198856429.001.0001.
Повний текст джерелаЧастини книг з теми "Continuous Crystallization System"
Nishio, S., T. Terado, H. Iwata, and M. Takeuchi. "Effects of Urinary Macromolecules on Calcium Oxalate Crystallization Studied by Continuous Flow System and Fresh Undiluted Urine." In Urolithiasis 2, 205–7. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2556-1_65.
Повний текст джерелаKawashima, Yoshiaki. "Future Perspectives of PLGA Nanospheres for Advanced DDSs and Continuous Preparation Systems for Spherical Crystallizers." In Spherical Crystallization as a New Platform for Particle Design Engineering, 107–18. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6786-1_8.
Повний текст джерелаWang, Jiayuan, and Richard Lakerveld. "Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling." In 13th International Symposium on Process Systems Engineering (PSE 2018), 1051–56. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-444-64241-7.50170-1.
Повний текст джерелаТези доповідей конференцій з теми "Continuous Crystallization System"
Washiya, Tadahiro, Toshimitsu Tayama, Kazuhito Nakamura, Kimihiko Yano, Atsuhiro Shibata, Kazunori Nomura, Takahiro Chikazawa, Masanobu Nagata, and Toshiaki Kikuchi. "Continuous-Operation Test at Engineering Scale Uranium Crystallizer System." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75339.
Повний текст джерелаWashiya, Tadahiro, Toshiaki Kikuchi, Atsuhiro Shibata, Takahiro Chikazawa, and Shunji Homma. "Development of Crystallizer for Advanced Aqueous Reprocessing Process." In 14th International Conference on Nuclear Engineering. ASMEDC, 2006. http://dx.doi.org/10.1115/icone14-89292.
Повний текст джерелаGlebov, L., and V. Smirnov. "Periodic structures in photo-thermo-refractive glasses induced by homogeneous UV irradiation." In Bragg Gratings, Photosensitivity, and Poling in Glass Fibers and Waveguides. Washington, D.C.: Optica Publishing Group, 1997. http://dx.doi.org/10.1364/bgppf.1997.jsue.15.
Повний текст джерелаSchmalenberg, Mira, Fabian Sallamon, Christian Haas, and Norbert Kockmann. "Temperature-Controlled Minichannel Flow-Cell for Non-Invasive Particle Measurements in Solid-Liquid Flow." In ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icnmm2020-1062.
Повний текст джерелаSchmalenberg, Mira, Lukas Hohmann, and Norbert Kockmann. "Miniaturized Tubular Cooling Crystallizer With Solid-Liquid Flow for Process Development." In ASME 2018 16th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icnmm2018-7660.
Повний текст джерелаYang, Yang, and Zoltan K. Nagy. "Application of nonlinear model predictive control in continuous crystallization systems." In 2015 American Control Conference (ACC). IEEE, 2015. http://dx.doi.org/10.1109/acc.2015.7172002.
Повний текст джерелаVlassov, Anatoly S., Felix A. Akopov, Evgeny S. Lukin, Vladimir N. Mineev, and Oleg M. Traktuev. "Sacrificial Layer Composition Optimization for Immobilization of Radioactive Waste in Nuclear Reactor External Catcher." In ASME 2001 8th International Conference on Radioactive Waste Management and Environmental Remediation. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/icem2001-1326.
Повний текст джерелаVinson, J. E., and M. J. Dion. "ESD Effects on Electromigration Performance of Aluminum Metallization Systems." In ISTFA 2000. ASM International, 2000. http://dx.doi.org/10.31399/asm.cp.istfa2000p0189.
Повний текст джерелаMasalova, Irina, and Alexander Ya Malkin. "Tube Transportation of Highly Concentrated Emulsions." In ASME 2006 2nd Joint U.S.-European Fluids Engineering Summer Meeting Collocated With the 14th International Conference on Nuclear Engineering. ASMEDC, 2006. http://dx.doi.org/10.1115/fedsm2006-98342.
Повний текст джерелаMighri, Frej, Luc Nguyen, and Said Elkoun. "Development and Characterization of Conductive Materials for PEMFC Bipolar Plates." In ASME 2010 8th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2010. http://dx.doi.org/10.1115/fuelcell2010-33091.
Повний текст джерела