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1
Steers, Helen. "Comparative analysis of community structure." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401076.
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2
Gardiner, Leslie J. (Leslie Jean) Carleton University Dissertation Management Studies. "The Organizational structure of transnational banks; a comparative analysis of global operations." Ottawa, 1988.
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3
Leies, Caroline Marie. "The term structure of zero-coupon and coupon bonds : a comparative analysis /." Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-06082009-171134/.
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4
Korobkov, Denis, Zhihua Liu, and Mingshi Yue. "A comparative analysis of business corruption in Russia and China." Thesis, Uppsala University, Department of Business Studies, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126896.
Повний текст джерелаАнотація:
This paper is a comparative analysis of Russian and Chinese markets in terms of businesscorruption. This study is based on quantitative and qualitative case analysis and small surveysaccording to different criteria.The aim of this work is to find out the general feature of corruption and show main differencesand similarities on corruption practices in Russian Federation and People’s Republic of China. Along with the comparative study this paper also presents general overview on corruption fromhistorical point of view. The results of the analysis show the main characteristics of the corruption phenomenon in China and Russia according to popularity of corruptive behavior, typology of bribes, reasons forcorruptive acts, impact from different local cultures, such as “Guanxi” and “Blat”, and also thestructure of enterprises. We believe that our work may be proved useful for further researches on this subject, and alsohelp business managers to avoid disadvantages caused by lack of knowledge on corruptionphenomenon when doing business in Russia and China.
5
Gebreegziabher, Yosef Alemu. "Ethiopia’s environmental federalism: problems and prospects an analysis in comparative perspective." University of Western Cape, 2009. http://hdl.handle.net/11394/3277.
Повний текст джерелаАнотація:
Magister Legum - LLMEthiopia is a federal state located in the horn of Africa. The Constitution has assignedlegislative, executive and judicial powers to the federal and regional Governments.1The main objective of this study is, therefore, to find out whether the decentralization of governmental powers between the national and the state governments of Ethiopia is also reflected in the decentralization of functional competences concerning environment related matters. In other words, this study attempts to determine whether Ethiopia is environmentally federal state, the extent and the possible shortcomings of the environmental federal structure. With this basic aim or objective in mind, in the study attempts will be made to see how the Constitution allocates the powers regarding environment among the federal, state, and local governments. To that effect, the role of the federal, the State and the local governments regarding the setting of environmental standards, pollution control and EIA will critically be analyzed. The match or the mismatch of the role of the federal as well as the state governments with their capacity will be investigated. Comparisons with selected legal systems will also be made for the purpose of identifying the practice of other systems in specific environmental matters selected for comparisons.
6
Stauffer, Robin James. "A comparative analysis of the Army Special Forces support structure to the Infantry Division (Light) support structure." Thesis, Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA243708.
Повний текст джерелаАнотація:
Thesis (M.S. in Management)--Naval Postgraduate School, December 1990.Thesis Advisor(s): Moore, Thomas F. Second Reader: Sturm, Mark. "December 1990." Description based on title screen as viewed on March 29, 2010. DTIC Descriptor(s): Logistics Support, Battalion Level Organizations, Army Personnel, Combat Support, Infantry, Efficiency, Theses, Nodes, Planning, Command And Control Systems, Supports, Division Level Organizations, Army, Army Operations, Unconventional Warfare, Channels, Organizations. DTIC Identifier(s): Special Operations Forces, Command And Control Systems, Army Operations, Combat Services Support, Logistics Management, Special Operations Support Command, Light Infantry Divisions, Military Organizations, Theses. Author(s) subject terms: Army Special Operations Forces, ARSOF, Combat Services Support, CSS, Logistics, Special Operations Support Command, SOSCOM. Includes bibliographical references (p. 117-118). Also available in print.
7
Sinclair, K. E. "The preservation of englacial structure : A comparative analysis of basal ice and till." Thesis, University of Canterbury. Geography, 1998. http://hdl.handle.net/10092/7028.
Повний текст джерелаАнотація:
Englacial structure (sedimentary and glaciotectonic) found in the basal zone of many glaciers can, in some circumstances, be preserved in till deposits. This structure provides evidence that can be used to infer the basal zone characteristics of former glaciers, and may therefore contribute to the reconstruction of past glacial environments.
The preservation of englacial structure results from passive deposition, which occurs under restricted conditions. Some of these conditions relate to the characteristics of the basal ice, and others to the nature of the proglacial environment. Sublimation is an inherently passive process that occurs when ice is transformed directly to water vapour, without an intermediate liquid phase. This process formed the basis of an arid polar model of deposition (Shaw 1977a).
Laboratory experiments conducted on basal ice samples from the Taylor Valley,
Antarctica, show that slow melt may also deposit till passively. Melt-out till was produced by allowing the debris to consolidate vertically, with little lateral dislocation during deposition. A comparative analysis of basal ice and laboratory-generated till deposits show that lamination, folding and banding were preserved. Two conceptual models of passive deposition illustrate that sublimation and slow melt may operate concurrently and in close association in arid polar environments. Both processes may lead to the preservation of englacial structure in arid polar environments, and it may be difficult to distinguish between sublimation and melt-out tills.
8
Louw, Hanneke. "A comparative and critical analysis of the corporate governance structure of South Africa." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/11677.
Повний текст джерелаАнотація:
Bibliography: leaves 77-81.The King Reports, as well as legislative developments culminating from these reports, are aimed at enhancing corporate governance standards in South Africa and aligning them with international best practice. Notwithstanding these measures, a number of significant failures in corporate governance rocked South African business during this period, severely denting the perception of the quality and standard of corporate governance. Given the importance of international investors' confidence, a continuous review of the South African corporate governance structure is imperative. This dissertation aims at performing a comparative and critical analysis of the corporate governance structures in South Africa. The objective is to seek alternative or improved corporate governance mechanisms that will enhance the current dispensation. For this purpose, various international corporate governance models are analysed and their monitoring mechanisms identified. The possibility of utilising some of these mechanisms to enhance corporate governance in South Africa is examined. The institutional environment in South Africa (I.e. the controlled shareholder environment, inactive and illiquid markets) prevents the market model mechanisms of the US and UK from playing a greater monitoring role. Further market model mechanisms aimed at promoting the independent monitoring of management have to a large extent been incorporated into the South African corporate governance framework. However, the ongoing failures of large listed and unlisted companies, including smaller banks in South Africa, that appear to indicate poor levels of, or ineffective, corporate governance, calls for the enforcement and acceptance of the monitoring guidelines set out in the King Reports. The German and Japanese bank governance model has a limited application in South Africa. The level of bank debt financing is generally lower than equity financing, thereby restricting banks' ability to become monitors through their debt control rights.
9
Merrill, Julia Carlson. "Focus in the structure of concepts in analytic discourse." CSUSB ScholarWorks, 2007. https://scholarworks.lib.csusb.edu/etd-project/3255.
Повний текст джерелаАнотація:
The primary focus of this thesis was to find out what makes workable topic sentences different from inadequate ones. A group of topic sentences was collected from the author's eight grade students and reviewed.
10
Madigoe, Mashikane William. "Syllable structure processes in Northern Sotho : a linear and non-linear phonological analysis." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53608.
Повний текст джерелаАнотація:
Thesis (MA)--Stellenbosch University, 2004.ENGLISH ABSTRACT: This study intends to describe and explain syllable structure processes in Northern Sotho. It deals with phonological processes such as vowel deletion, semivocalization and semivowel insertion. The major aim of these processes is to restore the preferred ICVI syllable structure which has been violated by morphological processes such as passive, diminutive, the construction of absolute pronouns, etc. Two phonological models are applied with the intention to determine the one that presents the most credible explanation for the phenomenon at hand. The two models employed are, respectively, the Transformational (TG) and Feature Geometry (FG) models. It appears that Feature Geometry model yields better results in the description of syllable structure processes in Northern Sotho.
AFRIKAANSE OPSOMMING: Hierdie studie beskryf en verklaar sillabestruktuur prosesse in Noord-Sotho. Die tersaaklike fonologiese prosesse is vokaaldelesie, semivokalisasie en semivokaalinvoeging. Die doel van hierdie prosesse is om "n bepaalde voorkeursillabestruktuur IKVI te herstel wat versteur word deur morfologiese prosesse met die vorming van die passief, diminutief, die konstruksie van absolute voornaamwoorde ensovoorts. Twee fonologiese modelle word geïmplementeer ten einde te bepaal welke model die mees geloofwaardige verklarings vir die betrokke verskynsels kan bied. Die Transformasioneel-Generatiewe (TG) en Kenmerk Geometriese(KG) modelle word respektiewelik toegepas. Dit skyn asof die Kenmerk Geometriese model beter resultate lewer in die beskrywing van sillabestruktuurprosesse in Noord-Sotho.
11
Mabhudhu, Mark. "A comparative analysis of leadership and management at Jwaneng Diamond Mine." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1578.
Повний текст джерелаАнотація:
Thesis (MPhil (Information Science))--Stellenbosch University, 2008.The functions of management and leadership are not new to the business fraternity. Whilst these functions are as pervasive and ubiquitous as the corporate organizations themselves, the same cannot be said of the organizational successes emanating from these functions. These functions have been cited throughout literature as pivotal in the successful running of businesses. By the same token, they have also been cited as the major causes of failed businesses within the corporate landscape. This has been established throughout small and big organizations alike. This unfortunate phenomenon has continued to attract significant academic and business research over the years with an overall intent of establishing why it is the case. Whilst there are varied reasons for the successes and failures of most organizations, the quality of both functions of leadership and management seem to take the larger portion of the praise and/or blame. These functions are regarded as key determinants of organizational success and survival into the future. Subsequently, this has culminated in myriad theories, frameworks and approaches around management and leadership as significantly different functions which yield different results in business organizations. At the core of the debate has been that management and leadership functions are different and depending on whether an organization is managed or led determines its future success and overall sustainability. It is therefore the intention of this study to comparatively analyze both functions of management and leadership in as far as they impact organizational sustainability and success. A case study of Jwaneng Diamond Mine in Botswana is used to do this comparative study of the two functions of management and leadership within the Executive team to try and affirm some of the key factors as alluded to within the business landscape. In this comparative study it is noted that whilst management and leadership are two different functions, they are however symbiotic in nature and successful organizations tap into both functions as they develop and build sustainable businesses for the future. The Jwaneng Mine case study showed that in an executive team, it is vital to have a balance between managers (those who provide management capabilities) and leaders (those that provide leadership) if the organization is to be successful going into the future.
12
Osborne, Olga Languages & Linguistics Faculty of Arts & Social Sciences UNSW. "Comparative analysis of atypical coordinate structures in Russian and English languages in correlation with field structure of grammatical category coordination." Publisher:University of New South Wales. Languages & Linguistics, 2009. http://handle.unsw.edu.au/1959.4/43738.
Повний текст джерелаАнотація:
This dissertation examines specific features of atypical coordinate structures (from now referred to as ACS) in both English and Russian languages: those features which differentiate ACS from typical coordinate structures, but nevertheless allow them to keep the status of coordinate structures. Comparing ACS with typical coordinate structures in terms of linguistic norms, this thesis provides a view of ACS as less standard, non-normative forms of syntactic representations of coordinate relations. Most research on coordinate structures focuses either on syntax, or on semantics. This dissertation advocates the expediency of a functional-dynamic approach to ACS, applying the methods of linguistics, psycholinguistics, cognitive linguistics and social linguistics. It argues that coordination is a complex speech-thinking mechanism and that ACS should be analysed by taking into account the cognitive-pragmatic-emotive intentions of the speaker. This dissertation proposes the analysis of structure, semantics and pragmatics of ACS in correlation with their functioning in a text. For the first time the thesis provides a comprehensive comparative analysis of ACS in English and Russian languages. This analysis demonstrates that the syntactically comparable translation of the majority of ACS from English to Russian and vice versa is possible due to the same factors involved in the process of ACS formation in both languages. It also shows that the absence of the same coordinate structure of idiomatic character in the other language makes the adequate translation impossible. This dissertation argues that all types of coordinate structures have the same invariant meaning of MULTITUDE, but syntactically this meaning is represented differently by typical and atypical coordinate structures. The result of the comparative analysis is the proposal of a nucleus-peripheral structure of coordination which represents the diversity of coordinate structures. In the nucleus-peripheral structure typical coordinate structures represent the nucleus and have prototypical status, whereas ACS represent the periphery; different types of ACS are arranged at different distances from the nucleus depending on how many common properties they share with prototypical structures. The fact that this structure can be applied to both English and Russian languages advocates for the common principles of coordinate structures formation mechanism in these otherwise unrelated languages.
13
Chae, Min Seok. "Comparative analysis of Listeria monocytogenes biofilm formation and characterization of cell viability and biofilm structure." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ43148.pdf.
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14
Bhagdikar, Divyaa. "Comparative analysis of ligand binding properties of transcriptional and translational S-box riboswitches." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1593683073097626.
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15
Ozer, Gungor. "Understanding protein structure and dynamics: from comparative modeling point of view to dynamical perspectives." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39577.
Повний текст джерелаАнотація:
In this thesis, we have advanced a set of distinct bioinformatic and computational tools to address the structure and function of proteins. Using data mining of the protein data bank (PDB), we have collected statistics connecting the propensity between the protein sequence and the secondary structure. This new tool has enabled us to evaluate new structures as well as a family of structures. A comparison of the wild type staphylococcal nuclease to various mutants using the proposed tool has indicated long-range conformational deviations spatially distant from the mutation point. The energetics of protein unfolding has been studied in terms of the forces observed in molecular dynamics simulations. An adaptive integration of the steered molecular dynamics is proposed to reduce ground state dominance by the rare low energy trajectories on the estimated free energy profile. The proposed adaptive algorithm is utilized to reproduce the potential of mean force of the stretching of decaalanine in vacuum at lower computational cost. It is then used to construct the potential of mean force of this transition in solvent for the first time as to observe the hydration effect on the helix-coil transformation. Adaptive steered molecular dynamics is also implemented to obtain the free energy change during the unfolding of neuropeptide Y and to confirm that the monomeric form of neuropeptide Y adopts halical-hairpin like pancreatic-polypeptide fold.
16
Steele, Jeffrey 1972. "Representation and phonological licensing in the L2 acquisition of prosodic structure." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38520.
Повний текст джерелаАнотація:
It is widely recognized that differences in both prosodic complexity and position-sensitive contrasts exist both within and across languages. In contemporary phonological theory, these differences are often attributed to differences between heads and non-heads and the asymmetries in licensing potential that exist between such positions.In this thesis, the consequences of such differences for the second language (L2) acquisition of prosodic complexity and position-sensitive contrasts are explored. It is argued that an explanatorily adequate account of L2 syllabification must include highly-structured representations as well as a theory of licensing, which distinguishes between the licensing of a given position and the licensing of featural content in such a position. Using data drawn primarily from a number of studies that investigate the acquisition of French by native speakers of English and Mandarin, it is demonstrated that the widely-attested interlanguage (IL) syllable-structure-modification processes of deletion, epenthesis, and feature change have a common source. Specifically, all three processes result from the IL grammar's inability to license a syllable position or (some of) the featural content present in such a position in the target representation. Within Optimality theory, the framework adopted, this is formalized through the competition between Faithfulness constraints and Markedness constraints, which evaluate the wellformedness of the licensing relationships. Finally, it is argued that Prosodic Licensing and the principle of Licensing Inheritance from Harris (1997) work together to encode prosodic markedness in representation, as they create a series of head-dependent asymmetries in which heads are strong licensors vis-a-vis their dependents.
17
Abril, Ferrando Josep Francesc. "Comparative analysis of eukaryotic gene sequence features." Doctoral thesis, Universitat Pompeu Fabra, 2005. http://hdl.handle.net/10803/7108.
Повний текст джерелаАнотація:
L'incessant augment del nombre de seqüències genòmiques, juntament amb l'increment del nombre de tècniques experimentals de les que es disposa,
permetrà obtenir el catàleg complet de les funcions cel.lulars de
diferents organismes, incloent-hi la nostra espècie. Aquest catàleg
definirà els fonaments sobre els que es podrà entendre millor com els
organismes funcionen a nivell molecular. Al mateix temps es tindran més
pistes sobre els canvis que estan associats amb les malalties. Per tant,
la seqüència en brut, tal i com s'obté dels projectes de seqüenciació de
genomes, no té cap valor sense les anàlisis i la subsegüent anotació de
les característiques que defineixen aquestes funcions. Aquesta tesi
presenta la nostra contribució en tres aspectes relacionats de
l'anotació dels gens en genomes eucariotes.
Primer, la comparació a nivell de seqüència entre els genomes humà i de
ratolí es va dur a terme mitjançant un protocol semi-automàtic. El
programa de predicció de gens SGP2 es va desenvolupar a partir
d'elements d'aquest protocol. El concepte al darrera de l'SGP2 és que
les regions de similaritat obtingudes amb el programa TBLASTX, es fan
servir per augmentar la puntuació dels exons predits pel programa
geneid, amb el que s obtenen conjunts d'anotacions més acurats
d'estructures gèniques. SGP2 té una especificitat que és prou gran com
per que es puguin validar experimentalment via RT-PCR. La validació de
llocs d'splicing emprant la tècnica de la RT-PCR és un bon exemple de
com la combinació d'aproximacions computacionals i experimentals
produeix millors resultats que per separat.
S'ha dut a terme l'anàlisi descriptiva a nivell de seqüència dels llocs
d'splicing obtinguts sobre un conjunt fiable de gens ortòlegs per humà,
ratolí, rata i pollastre. S'han explorat les diferències a nivell de
nucleòtid entre llocs U2 i U12, pel conjunt d'introns ortòlegs que se'n
deriva d'aquests gens. S'ha trobat que els senyals d'splicing ortòlegs
entre humà i rossegadors, així com entre rossegadors, estan més
conservats que els llocs no relacionats. Aquesta conservació addicional
pot ser explicada però a nivell de conservació basal dels introns.
D'altra banda, s'ha detectat més conservació de l'esperada entre llocs
d'splicing ortòlegs entre mamífers i pollastre. Els resultats obtinguts
també indiquen que les classes intròniques U2 i U12 han evolucionat
independentment des de l'ancestre comú dels mamífers i les aus. Tampoc
s'ha trobat cap cas convincent d'interconversió entre aquestes dues
classes en el conjunt d'introns ortòlegs generat, ni cap cas de
substitució entre els subtipus AT-AC i GT-AG d'introns U12. Al contrari,
el pas de GT-AG a GC-AG, i viceversa, en introns U2 no sembla ser inusual.
Finalment, s'han implementat una sèrie d'eines de visualització per
integrar anotacions obtingudes pels programes de predicció de gens i per
les anàlisis comparatives sobre genomes. Una d'aquestes eines, el
gff2ps, s'ha emprat en la cartografia dels genomes humà, de la mosca del
vinagre i del mosquit de la malària, entre d'altres. El programa
gff2aplot i els filtres associats, han facilitat la tasca d'integrar
anotacions de seqüència amb els resultats d'eines per la cerca
d'homologia, com ara el BLAST. S'ha adaptat també el concepte de
pictograma a l'anàlisi comparativa de llocs d splicing ortòlegs, amb el
desenvolupament del programa compi.
El aumento incesante del número de secuencias genómicas, junto con el
incremento del número de técnicas experimentales de las que se dispone,
permitirá la obtención del catálogo completo de las funciones celulares
de los diferentes organismos, incluida nuestra especie. Este catálogo
definirá las bases sobre las que se pueda entender mejor el
funcionamiento de los organismos a nivel molecular. Al mismo tiempo, se
obtendrán más pistas sobre los cambios asociados a enfermedades. Por
tanto, la secuencia en bruto, tal y como se obtiene en los proyectos de
secuenciación masiva, no tiene ningún valor sin los análisis y la
posterior anotación de las características que definen estas funciones.
Esta tesis presenta nuestra contribución a tres aspectos relacionados de
la anotación de los genes en genomas eucariotas.
Primero, la comparación a nivel de secuencia entre el genoma humano y el
de ratón se llevó a cabo mediante un protocolo semi-automático. El
programa de predicción de genes SGP2 se desarrolló a partir de elementos
de dicho protocolo. El concepto sobre el que se fundamenta el SGP2 es
que las regiones de similaridad obtenidas con el programa TBLASTX, se
utilizan para aumentar la puntuación de los exones predichos por el
programa geneid, con lo que se obtienen conjuntos más precisos de
anotaciones de estructuras génicas. SGP2 tiene una especificidad
suficiente como para validar esas anotaciones experimentalmente vía
RT-PCR. La validación de los sitios de splicing mediante el uso de la
técnica de la RT-PCR es un buen ejemplo de cómo la combinación de
aproximaciones computacionales y experimentales produce mejores
resultados que por separado.
Se ha llevado a cabo el análisis descriptivo a nivel de secuencia de los
sitios de splicing obtenidos sobre un conjunto fiable de genes ortólogos
para humano, ratón, rata y pollo. Se han explorado las diferencias a
nivel de nucleótido entre sitios U2 y U12 para el conjunto de intrones
ortólogos derivado de esos genes. Se ha visto que las señales de
splicing ortólogas entre humanos y roedores, así como entre roedores,
están más conservadas que las no ortólogas. Esta conservación puede ser
explicada en parte a nivel de conservación basal de los intrones. Por
otro lado, se ha detectado mayor conservación de la esperada entre
sitios de splicing ortólogos entre mamíferos y pollo. Los resultados
obtenidos indican también que las clases intrónicas U2 y U12 han
evolucionado independientemente desde el ancestro común de mamíferos y
aves. Tampoco se ha hallado ningún caso convincente de interconversión
entre estas dos clases en el conjunto de intrones ortólogos generado, ni
ningún caso de substitución entre los subtipos AT-AC y GT-AG en intrones
U12. Por el contrario, el paso de GT-AG a GC-AG, y viceversa, en
intrones U2 no parece ser inusual.
Finalmente, se han implementado una serie de herramientas de
visualización para integrar anotaciones obtenidas por los programas de
predicción de genes y por los análisis comparativos sobre genomas. Una
de estas herramientas, gff2ps, se ha utilizado para cartografiar los
genomas humano, de la mosca del vinagre y del mosquito de la malaria. El
programa gff2aplot y los filtros asociados, han facilitado la tarea de
integrar anotaciones a nivel de secuencia con los resultados obtenidos
por herramientas de búsqueda de homología, como BLAST. Se ha adaptado
también el concepto de pictograma al análisis comparativo de los sitios
de splicing ortólogos, con el desarrollo del programa compi.
The constantly increasing amount of available genome sequences, along
with an increasing number of experimental techniques, will help to
produce the complete catalog of cellular functions for different
organisms, including humans. Such a catalog will define the base from
which we will better understand how organisms work at the molecular
level. At the same time it will shed light on which changes are
associated with disease. Therefore, the raw sequence from genome
sequencing projects is worthless without the complete analysis and
further annotation of the genomic features that define those functions.
This dissertation presents our contribution to three related aspects of
gene annotation on eukaryotic genomes.
First, a comparison at sequence level of human and mouse genomes was
performed by developing a semi-automatic analysis pipeline. The SGP2
gene-finding tool was developed from procedures used in this pipeline.
The concept behind SGP2 is that similarity regions obtained by TBLASTX
are used to increase the score of exons predicted by geneid, in order to
produce a more accurate set of gene structures. SGP2 provides a
specificity that is high enough for its predictions to be experimentally
verified by RT-PCR. The RT-PCR validation of predicted splice junctions
also serves as example of how combined computational and experimental
approaches will yield the best results.
Then, we performed a descriptive analysis at sequence level of the
splice site signals from a reliable set of orthologous genes for human,
mouse, rat and chicken. We have explored the differences at nucleotide
sequence level between U2 and U12 for the set of orthologous introns
derived from those genes. We found that orthologous splice signals
between human and rodents and within rodents are more conserved than
unrelated splice sites. However, additional conservation can be
explained mostly by background intron conservation. Additional
conservation over background is detectable in orthologous mammalian and
chicken splice sites. Our results also indicate that the U2 and U12
intron classes have evolved independently since the split of mammals and
birds. We found neither convincing case of interconversion between these
two classes in our sets of orthologous introns, nor any single case of
switching between AT-AC and GT-AG subtypes within U12 introns. In
contrast, switching between GT-AG and GC-AG U2 subtypes does not appear
to be unusual.
Finally, we implemented visualization tools to integrate annotation
features for gene- finding and comparative analyses. One of those tools,
gff2ps, was used to draw the whole genome maps for human, fruitfly and
mosquito. gff2aplot and the accompanying parsers facilitate the task of
integrating sequence annotations with the output of homologybased tools,
like BLAST.We have also adapted the concept of pictograms to the
comparative analysis of orthologous splice sites, by developing compi.
18
Mesher, Gene Michael. "The political economy of telecommunications in Malaysia and Singapore a stakeholders-structure, conduct, performance comparative analysis /." Diss., The University of Arizona, 1998. http://catalog.hathitrust.org/api/volumes/oclc/44047336.html.
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Chavarría, Castillo Cindy Cecilia, Jar Carlos Alfredo Casquero, and Castillo Dionel Martínez. "Smuggling: its importance in the trinational region in front of the spatial structure." Pontificia Universidad Católica del Perú. Centro de Investigación en Geografía Aplicada, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/119820.
Повний текст джерелаАнотація:
The research focuses on the contraband´s spatial interactions that arise front to spatial structure, organization and pre existing complementary links, we identified through a diachronic analysis, establishing our field of study as the geographic area we call Trinational Macro Region: southern Peru, northern Chile and western Bolivia. This activity generates spatial dynamics and flows that are developed in the context of globalization and these exploit existing comparative advantages, i.e. the status of being neighbouring countries, the strategic location with respect to South America and the rest of the world, the communication channels, the absence of the state in these regions and price differentiation between licit products and contraband ones. These dynamic and flows, these are spatialize under various strategies adopted to transport contraband, storage and distribution of products.La investigación se centra en las interacciones espaciales del contrabando que surgen frentea una estructura espacial, organización y vínculos de complementariedad preexistentes, que identificamos mediante un análisis diacrónico, estableciendo como nuestro campo de estudio el área geográfica que denominamos macrorregión trinacional: el sur del Perú, el norte de Chiley el noroeste de Boliva. Esta actividad genera dinámicas espaciales y flujos que se desarrollan en el contexto de la globalización y aprovechan las ventajas comparativas existentes, es decir, la condición de ser países fronterizos, la localización estratégica con respecto a América del Sur y el resto del mundo, las vías de comunicación, la débil presencia del Estado en estas regiones y la diferenciación de precios entre los productos lícitos y los de contrabando. Estas dinámicas y flujos se espacializan bajo diversas estrategias que adopta el contrabando para el traslado, almacenamiento y distribución de los productos.
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Akca, Ayse. "A Comparative Analysis Of The Eu And Turkey: Macroeconomic Convergence And Trade Similarity." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612458/index.pdf.
Повний текст джерелаАнотація:
The aim of this thesis is to evaluate the sufficiency of Turkey for joining the Economic and Monetary Union of the European Union (EMU) in terms of similarity and convergence. The study has been conducted in a comparative and descriptive way. First, the similarity and convergence of Turkey to some selected countries are examined with respect to her macroeconomic position. When taking EMU as a benchmark and comparing the convergence of Turkey with the convergence of some of the countries and country groups, it is found that the macroeconomic deficiencies of Turkey are not in an extent that characterizes Turkey as a totally insufficient candidate for EMU. Next, whether there are similarity and convergence in trade structures of Turkey and the European Union of 15 member states (EU15) for the period between 1995 and 2008 is inspected. The results indicated that Turkish export structure is clearly converging to the export structure of EU15 in the course of time. In general, findings of the thesis indicated that there is mostly a continuous convergence in all of the indicators considered but still Turkey does not meet all of the convergence criteria, perfectly. Therefore, as a result of the examinations, some suggestions have been made which would facilitate EMU membership of Turkey.
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Hewlett, Brian. "Spiritual but not Religious Being: Exploring Structural Antecedents for the pairing of Spiritual and Non-Religious Identities across National Boundaries." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/196058.
Повний текст джерелаАнотація:
Recent research and popular discourse offers evidence of a significant number of people in the U.S. and elsewhere in the world that self-identify as both "spiritual" and "not religious." Based on the conventional religious paradigm that has previously been supported by western scholarship, spirituality is a factor of religious involvement and such an identity combination should be rare in societies where people overwhelmingly participate in church activities. However, these new empirical data challenge this supposition. This quandary has renewed an interest among academics in understanding the relationship between spirituality and religion and in identifying mechanisms that have an impact on variance on particular combinations of the two. This dissertation explores the antecedent nature of certain combinations of structural conditions across nation states in association with substantial aggregations of "spiritual but not religious" populations in an effort to offer empirical evidence that can be used to support theoretical arguments about the cross-national variation of this population. Using fuzzy set qualitative comparative methods and data from 32 nation states, this analysis explores the necessity and sufficiency of individual demographic and economic conditions, church and state relations, and popular attitudes about church involvement in politics while examining the consistency of their presence in paths that lead to "spiritual non-religious" identification. The results suggest that in the midst of an atmosphere of attitudes that oppose the involvement of religious organizations in politics that is related to the size of the institutional religious canopy, a nation's structural economic forces may be driving the variance in religious identification that is associated with spiritual identification. However, a full understanding of this relationship can only be gained through combining tests offered in this work with future qualitative cross-national studies that also consider subjective meaning.
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Backhouse, Rene. "An analysis of the grammatical structure of small clauses in Afrikaans : a minimalist approach." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95928.
Повний текст джерелаАнотація:
Thesis (MA)--Stellenbosch University, 2014.ENGLISH ABSTRACT: The main goal of this study is to provide a grammatical analysis of small clauses in Afrikaans. A proper analysis of this phenomenon has not yet been attempted in the literature on Afrikaans syntax. However, within the framework of generative grammar, including the most recent versions of Minimalist Syntax, extensive research has been conducted on the small clause phenomenon for a wide range of other languages. In these studies, various types of small clause constructions have been identified. For the purpose of this study, a systematic analysis is given for seven of these small clause construction types, focusing specifically on the Afrikaans data. In order to establish whether the Afrikaans small clause constructions exhibit the same characteristics as those found in other languages, a taxonomy is given of their Dutch, English, West Flemish and Polish counterparts as described by, among others, Hoekstra (1988a, 1992), Bennis, Corver and Den Dikken (1998), Citko (2008) and Haegeman (2010). It is against this background that the characteristics of the different Afrikaans small clause constructions are described. In addition, an explication is given of the various proposals regarding the underlying structure of such constructions. Based on proposals by Oosthuizen (2013), it is argued that a small clause construction is a projection of a particular functional category, namely a defective light verb, sc-v. It is claimed that such a light verb analysis can provide an adequate account of the Afrikaans facts.
AFRIKAANSE OPSOMMING: Die hoofoogmerk van hierdie studie is om ’n grammatikale analise van beknopte sinne (“small clauses”) in Afrikaans te verskaf. ʼn Behoorlike analise van hierdie verskynsel is nog nie tevore aangebied in die literatuur oor Afrikaanse sintaksis nie. Binne die raamwerk van generatiewe grammatika, insluitend die mees onlangse versies van Minimalistiese Sintaksis, is daar egter uitgebreide navorsing gedoen oor die verskynsel van beknopte sinne in ʼn verskeidenheid ander tale. In die betrokke studies is verskeie tipes beknopte sin-konstruksies geïdentifiseer. Vir die doel van hierdie studie word ’n sistematiese analise gegee van sewe van hierdie konstruksie-tipes, met spesifieke fokus op die Afrikaanse data. Ten einde vas te stel of die Afrikaanse beknopte sin-konstruksies dieselfde eienskappe toon as dié in ander tale, word ’n taksonomie verskaf van die ooreenstemmende konstruksies in Nederlands, Engels, Wes-Vlaams en Pools, soos beskryf deur onder meer Hoekstra (1988a, 1992), Bennis, Corver en Den Dikken (1998), Citko (2008) en Haegeman (2010). Dit is teen hierdie agtergrond dat die eienskappe van die verskillende Afrikaanse beknopte sin-konstruksies beskryf word. Verder word ʼn uiteensetting gegee van verskeie voorstelle oor die onderliggende struktuur van sulke konstruksies. Gebaseer op voorstelle deur Oosthuizen (2013), word daar geargumenteer dat ’n beknopte sin-konstruksie ’n projeksie is van ’n spesifieke funksionele kategorie, naamlik ’n defektiewe ligte werkwoord, sc-v. Daar word aangevoer dat so ’n ligte werkwoord-analise ’n toereikende verklaring kan bied van die Afrikaanse feite.
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Nindo, Fredrick Nzabanyi. "Exploring the phylodynamics, genetic reassortment and RNA secondary structure formation patterns of orthomyxoviruses by comparative sequence analysis." Doctoral thesis, Faculty of Health Sciences, 2019. https://hdl.handle.net/11427/31729.
Повний текст джерелаАнотація:
RNA viruses are among the most virulent microorganisms that threaten the health of humans and livestock. Among the most socio-economically important of the known RNA viruses are those found in the family Orthomyxovirus. In this era of rapid low-cost genome sequencing and advancements in computational biology techniques, many previously difficult research questions relating to the molecular epidemiology and evolutionary dynamics of these viruses can now be answered with ease. Using sequence data together with associated meta-data, in chapter two of this dissertation I tested the hypothesis that the Influenza A/H1N1 2009 pandemic virus was introduced multiple times into Africa, and subsequently dispersed heterogeneously across the continent. I further tested to what degree factors such as road distances and air travel distances impacted the observed pattern of spread of this virus in Africa using a generalised linear modelbased approach. The results suggested that their were multiple simultaneous introductions of 2009 pandemic A/H1N1 into Africa, and geographical distance and human mobility through air travel played an important role towards dissemination. In chapter three, I set out to test two hypotheses: (1) that there is no difference in the frequency of reassortments among the segments that constitute influenza virus genomes; and (2) that there is epochal temporal reassortment among influenza viruses and that all geographical regions are equally likely sources of epidemiologically important influenza virus reassortant lineages. The findings suggested that surface segments are more frequently exchanges than internal genes and that North America/Asia, Oceania, and Asia could be the most likely source locations for reassortant Influenza A, B and C virus lineages respectively. In chapter four of this thesis, I explored the formation of RNA secondary structures within the genomes of orthomyxoviruses belonging to five genera: Influenza A, B and C, Infectious Salmon Anaemia Virus and Thogotovirus using in silico RNA folding predictions and additional molecular evolution and phylogenetic tests to show that structured regions may be biologically functional. The presence of some conserved structures across the five genera is likely a reflection of the biological importance of these structures, warranting further investigation regarding their role in the evolution and possible development of antiviral resistance. The studies herein demonstrate that pathogen genomics-based analytical approaches are useful both for understanding the mechanisms that drive the evolution and spread of rapidly evolving viral pathogens such as orthomyxoviruses, and for illuminating how these approaches could be leveraged to improve the management of these pathogens.
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Eloire, Damien. "Spatial and temporal patterns of plankton in European coastal waters : analysis and comparison of zooplankton time series." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20059.
Повний текст джерелаАнотація:
Le changement climatique est incontestable et affecte les océans. L'observation à long terme d'indicateurs comme le plancton peut permettre l'étude de ces changements. Le suivi du plancton dans les eaux côtières d'Europe représente une source de données importante actuellement sous-exploitée et sur laquelle cette étude est basée. Des outils analytiques ont d'abord été conçus pour résoudre des divergences taxonomiques entre les données et pour réaliser l'analyse temporelle. L'étude du plancton à L4 de 1998 à 2007 révèle de profonds changements dans la composition phytoplanctonique des blooms de printemps et d'automne, et des variations à long terme dans l'abondance des taxa dominants du zooplancton. Le phytoplancton gouverne la succession saisonnière des larves méroplanctoniques. Les changements de température de surface et de vent contrôlent les variations temporelles des communautés planctoniques. Les variations spatio-temporelles du zooplancton ont été comparées à 4 sites de 1998 à 2007 : Ston (Mer du Nord), L4 (Manche), MC (Mer Tyrrhénienne ), et C1 (Mer Adriatique). La structure des communautés est globalement stable, la saisonnalité étant la principale source de variabilité à long terme. La chlorophylle a et le vent expliquent les variations de la communauté zooplanctonique à Ston et L4 alors que c'est la température à MC et C1. Cette étude confirme l'extrême adaptabilité des communautés zooplanctoniques à un environnement variable. Elle souligne l'importance de facteurs tels que taxonomie et échelle temporelle pour l'analyse de séries, et la nécessité de maintenir les séries à long terme pour le suivi de futurs changements dans le contexte du changement climatiqueClimate change is unequivocal and dramatic changes are under way in the world's oceans. Long-term observations of indicators such as plankton can provide a better understanding of these changes. Considerable efforts have been made to monitor plankton in European coastal waters and have produced a large amount of datasets yet to be fully exploited. Analytic tools were first developed to solve taxonomic discrepancies in datasets and for temporal analyses. Time series analysis of plankton at L4 from 1988 to 2007 reveals profound changes in the composition of the spring and autumn phytoplankton blooms, and long-term variations in abundance of the dominant zooplankton taxa. Phytoplankton is driving the seasonal succession of meroplanktonic larvae. Changes in sea surface temperature and wind conditions control temporal patterns of plankton communities. Spatio-temporal patterns of zooplankton are compared at 4 sites: Ston (northern North Sea), L4 (wes tern English Channel), MC (Tyrrhenian Sea), and C1 (Adriatic Sea) from 1998 to 2007. The communities structure is on average stable and seasonal variations are the main source of long-term variability. Chlorophyll a and wind are responsible for the community patterns observed at Ston and L4 whereas temperature is the main driver at MC and C1. This study supports evidences of the extreme flexibility of zooplankton communities in adjusting to a variable environment. We highlighted the importance of factors such as taxonomy and temporal scale on time series analysis, and the necessity of maintaining long-term series to monitor future changes in the context of climate change
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Crombie, Andrea Rene. "Lysosomal integral membrane protein II, a member of the CD36 gene family : comparative analysis of structure-function relationships /." Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733079741&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.
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Benton, Steven Bryant. "The term structure of interest rates : a comparative analysis of zero-coupon bond forward rates and Eurodollar futures rates /." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-06112009-063153/.
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Mwongera, David Thuranira. "Determining the population structure and avirulence gene repertoire of the rice blast fungus Magnaporthe oryzae in Kenya by comparative genome analysis." Thesis, University of Exeter, 2018. http://hdl.handle.net/10871/33087.
Повний текст джерелаАнотація:
Rice blast disease is caused by the ascomycete fungus Magnaporthe oryzae and is of economic importance worldwide, due to its wide geographical distribution and the severe yield losses it causes on cultivated rice. Understanding the population structure of M. oryzae is key to sustainable management of blast disease. In this study, a total of 290 M. oryzae isolates were collected from rice growing regions in Kenya including Central Kenya (Mwea irrigation scheme), Western Kenya (Ahero and Maugo irrigation schemes in Ahero and Homa-Bay respectively) and Coastal Kenya (Kwale). Initially, I undertook genotyping of a subset of Kenyan isolates by DNA sequence analysis of the internal transcribed spacer regions (ITS 1 and ITS 2) of the rRNA-encoding gene unit and by DNA fingerprinting using the Pot2 repetitive DNA element. Phylogenetic analyses based on ITS sequences clustered together isolates from Western and Coastal Kenya which were distinct from Central Kenya isolates. Cluster analysis based on 80% DNA fingerprint similarity, identified five clonal lineages designated KL1, KL2, KL3, KL4 and KL5 with most isolates belonging to lineages KL2, KL3, KL4. The clustering of isolates was region specific with Western and Coastal isolates closely related to each other and distinct from Central Kenya isolates. Distribution of mating type gene loci (MAT1.1 and MAT1.2) was determined using mating type gene specific primers. My results indicate that MAT1.1 is the predominant mating type and is distributed in all the rice growing regions of Kenya. MAT1.2 isolates were identified only in Coastal Kenya. I further undertook high throughput next-generation DNA sequencing of the genomes of 27 M. oryzae isolates from sub-Saharan Africa (SSA), including Kenya, Uganda, Tanzania, Benin, Togo, Nigeria and Burkina Faso and compared them to other sequenced strains from China, India, USA, Philippines, Thailand, Korea, Japan, France and French Guiana. Single nucleotide polymorphisms (SNPs) indicated that majority of East African isolates of M. oryzae clustered separately from West African isolates. African isolates clustered with isolates from India and China, indicating that rice blast in SSA may have originated from Asia. Pathotype analysis of Kenyan isolates was undertaken using a set of monogenic differential rice varieties, collectively harbouring 24 disease resistance genes. Rice blast resistance gene Pi-z5 conferred resistance to all the isolates tested. Other resistance genes that conferred resistance to majority of isolates tested include Pi-9, Pi-12(t), Pi-ta, Pi-ta2 and Pi-z. These resistance genes are suitable candidates for introgressing into commercially grown varieties in Kenya in combinations. I also investigated the population of M. oryzae isolates to identify cognate avirulence gene loci, including novel genes not yet reported. Finally, I evaluated rice varieties grown in Kenya for resistance to indigenous rice blast isolates under laboratory conditions. Rice variety Basmati 370 was susceptible to rice blast with varieties IR2793-80-1, BW 196, NERICA 1, NERICA 4, NERICA 10, and NERICA 11 showing some disease resistance. Varieties ITA 310 and Duorado Precoce were moderately tolerant to rice blast. This information is being used to develop a durable blast resistance strategy in sub-Saharan Africa.
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Clark, Amy Elizabeth. "Spatial Structure and the Temporality of Assemblage Formation: A Comparative Study of Seven Open Air Middle Paleolithic Sites in France." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556880.
Повний текст джерелаАнотація:
The spatial arrangements of artifacts and features within archaeological sites have often been used to isolate activity areas and draw inferences about site function. This approach assumes that objects found in close proximity were used for the same task, and that artifacts are usually discarded where they were used. However, the location of artifact abandonment often has more to do with patterns of discard and use/reuse of the site throughout time than with the function or location of activities. This dissertation uses a comparative framework to address how the observed spatial structure of Middle Paleolithic sites in France sites was formed through centrifugal dispersion of lithic artifacts, i.e. the displacement of artifacts between their creation and the final location of their abandonments. Seven Middle Paleolithic sites were included in this study. The sites were excavated over large areas, from 200 to more than 2000 m². They range from small single component occupation sites to lithic raw material workshops with assemblages of more than 15,000 artifacts. The movement of artifacts is tracked through an analysis of sets of refitted lithics and through comparisons of the distributions of multiple classes of artifact across areas of the sites with differing artifact densities. Studying the distribution of lithic technological classes and tracking their movement through refitting sets provides new perspectives on the ways Paleolithic archaeological assemblages and sites were formed. The temporality of site use had a much greater impact on site structure than did activities that took place at any one point during a site's occupation. These data enabled me to assess the relative lengths and numbers of occupations for the seven sites in this study. The approach taken in this study not only provides a clearer understanding of site formation and structure than do studies that strive to isolate "activity areas," but it also provides information about the sizes of past human groups and the ways they moved among different localities on the landscape. Such insights are integral to the study of land use, mobility and economic adaptations among Paleolithic hunter-gatherers.
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Koppermann, Claudia [Verfasser], Wolfgang [Gutachter] Werr, Ulrich [Gutachter] Baumann, and Karin [Gutachter] Schnetz. "Crystal Structure of the WUSCHEL Homeodomain - Description and Comparative Structural Analysis of a Novel Homeodomain Subtype / Claudia Koppermann ; Gutachter: Wolfgang Werr, Ulrich Baumann, Karin Schnetz." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/1153121050/34.
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Naffa, Rafea, C. Maidment, G. Holmes, and G. Norris. "Strong skin, not always thick - 30: Comparative structural and molecular analysis of deer skin and cow hide." Verein für Gerberei-Chemie und -Technik e. V, 2019. https://slub.qucosa.de/id/qucosa%3A34089.
Повний текст джерелаАнотація:
Content:
A comprehensive analysis of the molecular and structural components of deer skin and cow hide was undertaken. These skins known to be strong, however they derive their strength from different combinations of molecular and structural properties. Firstly, the physical properties of deer skin and cow hide including the tensile strength, tear strength and denaturation temperature were measured. Secondly, the structure of the collagen fibrils and glycosaminoglycans was investigated using transmission electron microscopy (TEM), and small angle X-ray scattering (SAXS). Finally, the chemical composition of deer skin and cow hide such as amino acids, crosslinks and glycosaminoglycans were analysed. Our results showed that physical properties of deer skin and cow hide are derived from different combinations of several chemical components resulting in different architecture. It was found that the large and “wavy” collagen fibres in deer skin made up of collagen fibrils with small diameters. Additionally, deer skin fibrils appeared to be linked by regular arrays of filaments of large glycosaminoglycans that are distributed uniformly. Deer skin contained higher proportion of trivalent collagen crosslinks. In contrast, the collagen fibrils in cow hide were large, contained a diverse glycosaminoglycan distribution and a higher proportion of tetravalent collagen crosslinks, resulting in straight collagen fibres. This study suggests that although deer skin and cow hide are both strong, they have different structural and molecular features.
Take-Away:
Deer skin and cow hide have different structural and molecular make up which are reflected in their physical properties particularly strength.
Glycosaminoglycans are important for the organisation of collagen fibrils in deer skin and cow hide.
Deer skin and cow hide contain different ratios of collagen natural crosslinks which are essential collagen stability.
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Gujar, Purva (Purva Prakash). "Organizational structure in the hospitality industry : a comparative analysis of hotel real estate investment trusts (REITs) and hotel C-Corporations." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77122.
Повний текст джерелаАнотація:
Thesis (S.M. in Real Estate Development)--Massachusetts Institute of Technology, Program in Real Estate Development in Conjunction with the Center for Real Estate, 2012.Cataloged from department-submitted PDF version of thesis. This electronic version was submitted and approved by the author's academic department as part of an electronic thesis pilot project. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references (p. 102-108).
Current legislation has made it possible for real estate investment trusts (REITs) to earn income beyond purely passive sources such as rents from real property or interest from mortgages on real property. As a result, both the number and market capitalization of hotel REITs have substantially increased, and the difference between hotel REITs and hotel C-corporations has narrowed. However, companies such as Starwood Hotels have reverted back to the C-corporation structure. Given these organizational changes and the increasing dominance of hotel REITs, there is a need to analyze hotel REITs and hotel C-corporations in a comparative framework. Equity REITs and C-corporations have been studied extensively. However, research on various organizational forms in the hospitality industry is somewhat limited. This study attempts to fill this gap by comparing the stock market performance of publicly traded hotel REITs with hotel C-Corporations from 1993 to 2011. Furthermore, the impact of significant events such as mergers and acquisitions and legislative amendments on firms' stock price are also observed. Finally, detailed case studies of companies that underwent corporate restructuring are conducted. The research objective of this thesis is to examine (a) whether REITs are an efficient organizational structure for the lodging industry; and (b) whether the tax benefits of REITs offset the regulatory constraints they face. The study infers that REIT acquirers have an advantage in mergers and acquisitions, but in all other situations, the net benefits of REITs are not as clear. On market cap basis, the performance of hotel REITs and hotel C-Corporations was almost identical, however when equally weighted, hotel REITs outperformed their C-Corporation counterparts. In addition, the results show that the REIT returns are highly volatile. On a broad level the hospitality business has two distinct segments -- ownership of hotels and management of hotels and the degree of operating flexibility offered is one of the main factors that differentiate REITs from the C-Corporation counterparts. Therefore, this study concludes that the choice of corporate structure depends greatly on a firm's business strategy.
by Purva Gujar.
S.M.in Real Estate Development
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Ellis, Tracy. "Gastrocnemius muscle structure and function in habitually resistance-trained marathon runners and traditionally running-trained marathon runners: a comparative analysis." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25253.
Повний текст джерелаАнотація:
Background: Marathon running involves running long distances and is associated with a high prevalence of running-related injuries. The calf has been identified as one of the most commonly injured structures during running. Running training causes an overload on muscle and stimulates a physiological adaptation to create a training response. Specific adaptations in metabolic and physiological function of a muscle may be further achieved through specificity of exercise training. Resistance training programmes are commonly implemented to enhance specific muscle strength and endurance; and are effective methods of performance and injury prevention. While evidence-based guidelines for resistance training exist, it is unclear whether runners are routinely incorporating evidence-based resistance training into marathon training programmes. If runners are performing habitual resistance training, it is also unknown if the resistance training is of sufficient magnitude or intensity to induce dose-related responses in calf muscle structure or function. Aim: The aim of this study was to evaluate gastrocnemius muscle structure and function in marathon runners who performed habitual resistance training in addition to regular endurance training, compared to marathon runners who performed traditional endurance running training only. Specific Objectives: • To describe the demographic and training characteristics of habitually resistance-trained marathon runners and traditionally running-trained marathon runners. • To determine if there were differences in gastrocnemius endurance, power and flexibility between habitually resistance-trained marathon runners and traditionally running-trained marathon runners. • To evaluate if there were differences in the gastrocnemius muscle structure and architecture in habitually resistance-trained marathon runners compared to traditionally running-trained marathon runners. • To establish if there were any differences in the number of calf injuries sustained in habitually resistance-trained marathon runners and traditionally running-trained marathon runners. Methods: Healthy male runners between 20 and 50 years were included in the study. Participants were required to have completed at least one marathon in the 12-month period prior to the study. Runners forming the "traditionally running-trained" group were required to be participating in regular endurance running training only. Runners in the "habitually resistance-trained group" were required to be performing resistance training in addition to regular endurance running training. Runners with any injury at the time of recruitment or runners who reported a calf injury within the six-month period prior to the study were excluded. Participants with any medical abnormalities detected during screening were also excluded from the study. Eight marathon runners participating in habitual resistance training plus standard running training and eleven marathon runners participating in traditional running training only were recruited for this study. Runners who met the criteria attended two testing sessions at least three days apart. During the first session, informed consent was obtained and the Physical Activity Readiness Questionnaire (PAR-Q) was completed to ensure participants could safely complete physical testing. A questionnaire was completed to determine relevant training and injury history. Body mass, height and the sum of seven skinfolds were recorded. Muscle architecture measurements, including fascicle length, pennation angle, thickness and volume, were performed via imaging ultrasound. Participants were then familiarised with the physical testing procedures. In the second testing session, calf muscle flexibility and endurance were assessed; and isokinetic testing was performed for the left and right triceps surae. Results: There were no significant differences in descriptive characteristics between groups. Participants in the habitually resistance-trained group performed in an average of two hours (range 0.5-2.5 hours) of resistance training of between one to four sessions per week. Participants combined upper and lower body training in the form of circuit training, body weight training, core and proprioceptive training. Resistance training sessions were performed at a varied intensity for load (light to high) according to an estimated 1RM. Participants in the habitually resistancetrained group had completed a significantly greater number of 21.1 km races compared to the traditionally running-trained group (p < 0.05); but there were no other differences in running training or competition history between groups. There were also no significant differences in the number of reported injuries between groups. Average pennation angle was significantly increased in the habitually resistance-trained group compared to the traditional running-trained group (p < 0.05). No other significant differences in architectural measurements were identified. There were no significant differences in calf muscle flexibility, strength, power or endurance between the two groups. However, the small sample size limits the interpretation of the study findings. Conclusion: Wide variability in habitual resistance training patterns were identified. While pennation angle was significantly greater in the habitually resistance-trained group; no differences in all other architectural measurements; or calf muscle strength, power, endurance or flexibility between groups were identified. However, one of the key findings emerging from this study is the variable resistance training practices in endurance runners; and that resistance training practices were not aligned to current evidence-based guidelines for resistance training. Resistance training has a critical role in enhancing endurance running performance, injury prevention and rehabilitation. Future research should investigate the knowledge, attitudes and practices of endurance runners regarding resistance training; to facilitate the development of appropriate education interventions, and to effectively disseminate evidence-based training guidelines to lay communities.
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Woodcock, M. Ryan. "Network Analysis and Comparative Phylogenomics of MicroRNAs and their Respective Messenger RNA Targets Using Twelve Drosophila species." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/155.
Повний текст джерелаАнотація:
MicroRNAs represent a special class of small (~21–25 nucleotides) non-coding RNA molecules which exert powerful post-transcriptional control over gene expression in eukaryotes. Indeed microRNAs likely represent the most abundant class of regulators in animal gene regulatory networks. This study describes the recovery and network analyses of a suite of homologous microRNA targets recovered through two different prediction methods for whole gene regions across twelve Drosophila species. Phylogenetic criteria under an accepted tree topology were used as a reference frame to 1) make inference into microRNA-target predictions, 2) study mathematical properties of microRNA-gene regulatory networks, 3) and conduct novel phylogenetic analyses using character data derived from weighted edges of the microRNA-target networks. This study investigates the evidences of natural selection and phylogenetic signatures inherent within the microRNA regulatory networks and quantifies time and mutation necessary to rewire a microRNA regulatory network. Selective factors that appear to operate upon seed aptamers include cooperativity (redundancy) of interactions and transcript length. Topological analyses of microRNA regulatory networks recovered significant enrichment for a motif possessing a redundant link in all twelve species sampled. This would suggest that optimization of the whole interactome topology itself has been historically subject to natural selection where resilience to attack have offered selective advantage. It seems that only a modest number of microRNA–mRNA interactions exhibit conservation over Drosophila cladogenesis. The decrease in conserved microRNA-target interactions with increasing phylogenetic distance exhibited a cure typical of a saturation phenomena. Scale free properties of a network intersection of microRNA target predictions methods were found to transect taxonomic hierarchy.
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Ulker, Eser Meltem. "A Comparative Analysis Of Thesis Guidelines And Master Thesis Abstracts Written In English At Universities In Turkey And In The Usa." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614008/index.pdf.
Повний текст джерелаАнотація:
This study examines master of art (MA) theses abstracts written in English in terms of their texual structures. In order to design a comparative study, abstracts are collected from universities (i) with a guideline in Turkey (ii) without a guideline in Turkey and (iii) with a guideline in the USA. 94 abstracts, randomly selected from these three groups of universities, are analyzed according to a content criteria list
developed on the basis of Swales (1981, 1990, 2004), and Hyland&rsquos (2000) textual structure models and content instructions provided in thesis writing guidelines. The analysis of data is accomplished using MS Excel 2010 ve SPSS 16.0. The comparison between abstracts written at universities with and without a guideline in Turkey revealed a significant difference in terms of methodology and statement of the problem. Also, with regards to the order of the rhetorical elements (Introduction+Methodology+Results+Conclusion), universities with a guideline in Turkey displayed more consistency than the universities without a guideline. As for the comparison between the universities with a guideline in Turkey and the USA, the results showed that there is a significant difference between the two abstract sets in terms of their methodology, results, and conclusion parts. Besides, the texual pattern analysis showed that abstracts collected from universities with a guideline in Turkey follow a more consistent order than their counterparts in the USA. The results of the thesis have pedagogical implicatons for students, teachers, academics who prepare thesis writing guidelines, and researchers who want to make publications internationally.
35
Lavoie, Brian F. "Real options and the management of R & D investment : an analysis of comparative advantage, market structure, and industry dynamics in biotechnology /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1079743252.
Повний текст джерелаАнотація:
Thesis (Ph. D.)--Ohio State University, 2004.Title from first page of PDF file. Document formatted into pages; contains xiii, 202 p.; also includes graphics. Includes abstract and vita. Advisor: Ian M. Sheldon, Dept. of Agricultural, Environmental and Development Economics. Includes bibliographical references (p. 197-202).
36
Hsiao, I.-Chun. "A strategy for the vocational education and training structure of the beauty profession in Taiwan, with lens comparative analysis of the UK." Thesis, De Montfort University, 2016. http://hdl.handle.net/2086/13116.
Повний текст джерелаАнотація:
The aim of this study is to review Taiwan’s training structure through a lens comparative study on the UK’s training approach for beauty professionals. Due to the distinctive differences between Taiwan and the UK, the methodological approach was designed differently for each in order to meet the aim and objectives. Apart from document analysis used for both countries, auto-ethnography was conducted in the UK; while in Taiwan observations and expert interviews were employed to identify the fundamental causes of the mismatch between education and industry. A strategy was proposed, based on the strong points identified from the UK, to improve the current structure of Taiwan. Three key features are identified from the UK that could be considered to alleviate Taiwan’s fundamental problems. They are respectively: National Occupational Standards, a Professional Body and a Quality Assurance process. Three key features are new to Taiwan, so that their implementation requires time and collaborative effort from the Taiwanese government, vocational education and industry. These features were embedded in three proposed models. Three models were proposed as a holistic structure to include all relevant stakeholders. The three models are the Service, Work Placement and Nurturing models. The impact of this study on Taiwan training structure will be substantial because it is the first step to bring all relevant stakeholders to communicate and interact through setting an agreed standard and through the treatment service framework provided by the Service Model. Secondly, the Work Placement Model provides a structure for assessment in workplaces to ensure that learning takes place in the workplace and to create an opportunity of knowledge sharing, allowing the theory to meet the practice. Thirdly, an overall Nurturing model of the training for beauty professionals is developed, with a professional body to provide a platform for all stakeholders, including government. Ultimately, everyone involved in the profession would be benefited and more importantly, the broad concepts and models might be of use to other domains.
37
Olver, Sophie. "Towards a 'late rentier' structure of labour market governance in the Gulf Cooperation Council : a comparative analysis of Saudi Arabia, Kuwait and Qatar." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761034.
Повний текст джерелаАнотація:
Throughout the Gulf Cooperation Council (GCC) Member states, a number of significant policy reforms have coincided with significant changes in their socio-economic trajectories. This is especially evident within the employment domain, where a rapidly increasing labour force challenges the capacity of the regions domestic labour markets to provide employment. With increasing unemployment rates, combined with the region’s burgeoning young population, of whom some are well educated and seeking first-time employment, strain is placed on labour markets that were traditionally characterised by high levels of inactivity, a low skills base for the native population, the substantial presence of migrant labour and extensive segmentation and inequalities across wage and gender lines. The political implications for the future political stability and regime legitimacy in these states are easy to imagine and the challenges ahead are substantial. Moreover, policies aiming to sustainably increase the capacity of domestic labour markets to provide employment for the national citizenry are currently developed in a context where the Gulf States have to navigate their repositioning in the global economic architecture by diversifying their economies and reorganizing their socio-political formations towards ‘late rentier’ governance structures. Against this background, this thesis explores how GCC governments are attempting to transform their rentier based political economies, by comparatively analysing recent labour market reforms in three Gulf states, namely Saudi Arabia, Kuwait and Qatar. A mixed methodological approach has been adopted, whereby through conducting a policy analysis on key labour reforms, namely the Kafala sponsorship system and Nationalisation based policies, alongside elite semi-structured interviews with key stakeholders, this thesis has contributed to the identification of the emerging trends which characterise the post-rentier labour market governance structures in the GCC. Furthermore, due to the different development visions adopted by these three states, this thesis highlights the marked diversity within the regionally adopted policies of the Kafala system and Nationalisation based reforms and, thus, contributes to our understanding of the emerging variety of late rentier political economies in the region and their likely future developmental paths.
38
Babenko, Vitalina, O. I. Boichenko, and Yelyzaveta Koniaieva. "Efficiency of human resource management in industrial automation enterprises with prospects of innovative susceptibility." Thesis, Atlantis Press, Netherlands, 2019. http://repository.kpi.kharkov.ua/handle/KhPI-Press/42534.
Повний текст джерелаАнотація:
In modern conditions of innovative development, the most important resource of production companies and
corporations is the innovative susceptibility (IS) of personnel. The key to this is an innovative organization of the personnel management system (HRMS). Accordingly, the task of the study is to analyze the typical HRMS structures of Ukrainian enterprises in comparison with the global ones in order to form an innovative HRMS development strategy and, on this basis, to increase IS of stuff. The goal of this study is to compare the levels of HRMS development in advanced global companies and Ukrainian enterprises in the field of industrial automation. As part of this study, methodological, statistical analysis method of technical and economic characteristics of Ukrainian and world leaders of enterprises in the field of industrial automation are used. As well as, comparative analysis method to characterize the organizational management structures of enterprises;
method of expert and analytical assessments of HRMS, including analytical trend analysis to characterize the dynamics of the influence of the HRMS subsystems of industrial automation enterprises on the level of innovative susceptibility of personnel. The result of the study is to obtain an assessment of the impact of HRMS subsystems of industrial automation enterprises on the level of innovation susceptibility of personnel, as well as the formation of the potential field of innovation susceptibility of personnel based on measures to increase the innovation of organizational management systems of an enterprise.
39
Groene-Holloway, Kayla Elizabeth. "Assessing Teacher-Student Relationships among Middle School Students With Multiple Suspensions." Xavier University Leadership Studies & Human Resource Development / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=xulead1622730824502568.
Повний текст джерела
40
Derrington, Kathryn. "Comparative analysis of perceptions of metacognitive processes in traditional school leavers and mature age entry students in their first year of university education." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16443/.
Повний текст джерелаАнотація:
Within the educational psychology literature there is an abundance of research in the field of metacognition. The concentration of this research however has been in primary and secondary school contexts with little attention given to tertiary students' understanding or use of metacognition; there has been even less attention to whether age is a factor in tertiary students' perceptions of their metacognitive processes. The primary purpose of this study was to explore the perceptions of two distinct groups of first year university students, towards their understanding and usage of metacognitive processes and strategies. The two groups defined were traditional school leavers and mature age students. The findings from the exploration of these perceptions were compared to ascertain the similarities and differences in metacognitive processes between the two cohorts. The data collected for this study were obtained through a process of individual face-to-face in- depth interviews. The choice of this methodology was deliberate in order to gather rich data about the students' perceptions and experiences rather than attempt to measure their levels of metacognition against some predetermined standard. Data were collected and analyzed on the two constructs of metacognition which were identified in the literature search. These were metacognitive knowledge and metacognitive control. A range of affective variables such as self efficacy, motivation and expectancy of success, which impact on students' metacognitive abilities and processes, were also considered in the data collection and analysis. The findings indicated that age was a factor in determining some differences and similarities in students' perceptions of their own and others metacognitive processes. In certain cases the traditional school leavers' recency of experience with formal study was deemed an advantage; in others the life experience of the mature age students was perceived an advantage. In some instances the age of the student had no discernable impact on their understanding of, and ability to, utilize metacognitive strategies. These findings assist to broaden the understanding of student perceptions of metacognition in the tertiary context. The findings also make it imperative that tertiary institutions make fewer assumptions about the skills and abilities of their commencing students based on the criterion of age and offer more opportunities to assist students to understand the value of developing and improving their metacognitive processes.
41
Duszka, Christopher Damian. "School Climate in the School Choice Era: A Comparative Analysis of District-Run Public Schools and Charter Schools." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3922.
Повний текст джерелаАнотація:
Comparative analyses of district-run public schools and charter schools are limited to performance outcomes. There is a dearth of research on how the school-types vary on factors consequential to performance such as school climate. Public-private distinctions, such as in organizational autonomy, value orientations, funding structures, and management practices, could result in school climate dissimilarities between district-run public schools and charter schools.
The aim of this dissertation is to assess the influence organizational factors have on school climate and determine if school-type affects school climate. Student and staff school climate survey data from the Miami-Dade school district were utilized for this dissertation. Structural equation modeling was employed to test theoretical models of students’ and staffs’ perceptions of school climate using data from 2001-2002 through 2015-2016 academic years. Within-between effects panel regression was utilized to test the effect of school-type on school climate constructs over time using data from 2005-2006 through 2015-2016 academic years.
The structural equation results demonstrate that milieu, ecology, culture, and organizational structure influence students’ and staffs’ perceptions of their schools’ climates. Ecology has the strongest association with students’ perceptions of school climate. Job satisfaction, a part of milieu and culture, has the strongest association with staffs’ perceptions of school climate. The results indicate that the theoretical models of school climate employed by this study are sound.
The within-between effects panel regression results demonstrate that characteristics inherent to school-type have a plausible influence on students’ perceptions of school climate, but not for staff. Charter school students rated their school climates more favorably than traditional public schools, but when other factors are controlled, traditional public schools and magnet schools had more favorable ratings. Public-sector values, collective bargaining, and school district oversight may be beneficial to schools’ climates.
This dissertation underscores the impact management and funding structures have on school climate. The author recommends that the school climate concept and evaluations of schools’ organizational practices be incorporated into school improvement policies. The milieu, culture, ecology, and organizational structures of schools should be reviewed when assessing school quality.
42
Olivier-Deyris, Laurence. "Etude structurale de la glycéraldéhyde-3-phosphate déshydrogénase d'Escherichia coli." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10175.
Повний текст джерелаАнотація:
Les structures cristallographiques de la forme holo de la gapdh d'escherichia coli native et d'un mutant n313t ont ete determinees et comparees a la structure cristallographique de la gapdh de bacillus stearothermophilus (formes apo et holo). Ces gapdh, nad dependantes, catalysent la phosphorylation oxydative du d-glyceraldehyde-3-phosphate (g3p) en acide 1,3-diphosphoglycerate (1,3-dpg): g3p+nad#++hpo#2#-#4 = 1,3-dpg+nadh+h#+ elles appartiennent au groupe des gapdh glycolytiques. Alors que les autres gapdh de structure 3d connues ont ete cristallisees en presence de sulfate, analogue du phosphate substrat de la reaction, les gapdh native et mutee de e. Coli ont pu etre cristallisees en presence de citrate, avec addition de nad pour saturer les sites de fixation du coenzyme. Les donnees cristallographiques sont: pour l'enzyme native: groupe d'espace c222#1, maille a=79,14a, b=189,56a, c=122,18a, facteur r=19,7% (58328 reflexions entre 8a et 1,8a). Pour l'enzyme mutee n313t: groupe d'espace c222#1, maille a=79,8a, b=188,8a, c=122,7a, facteur r=20,6% (46779 reflexions entre 8a et 2,1a). Pour les 2 structures, l'unite asymetrique comprend 2 monomeres. Elles ont ete resolues par la methode du remplacement moleculaire, avec pour modele la gapdh de b. Stearothermophilus. La comparaison des gapdh de e. Coli et de b. Stearothermophilus montre: une grande conservation de la structure, malgre une homologie de sequence de seulement 57,6%. Des differences localisees au niveau de certaines boucles et des interfaces, et dans l'orientation relative des domaines catalytiques et de fixation du cofacteur. La comparaison des gapdh native et mutee n313t de e. Coli montre que la zone asn31-va189 pourrait etre impliquee dans la cooperativite. La modelisation des complexes enzyme-substrat montre que le cofacteur nad/nadh ne peut pas etre present en meme temps que le substrat dans l'acylenzyme, et que le site pi est trop loin du substrat pour etre la position du phosphate inorganique reactif
43
FLORENTZ, EGELE CATHERINE. "L'extremite 3'oh aminoacyable du rna du virus de la mosaique jaune du navet : relations entre structure et fonctions." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13181.
Повний текст джерелаАнотація:
Analyse structurale (structure secondaire et tertiaire) d'un fragment contenant la sequence "trna like" (extremite 3' oh possedant plusieurs caracteristiques d'un arn de transfert). Modelisation de la structure sur ecran graphique. Analyse des zones de contact entre ce fragment d'arn et la valyl-trna synthetase, a l'aide de differentes sondes structurales. Discussion sur le role de l'extremite "trna like" dans le cycle de developpement du virus (regulation de la traduction de l'information genetique portee par l'arn viral)
44
Peinnequin, André. "La nadh : ubiquinone oxydoréductase de la bactérie photosynthétique Rhodobacter capsulatus : étude et caractérisation de 5 gènes (nuo8, nuo10, nuo11, nuo12 et nuo13) homologues aux gènes mitochondriaux nd1, nd6, nd4L, nd5 et nd4." Université Joseph Fourier (Grenoble ; 1971-2015), 1994. http://www.theses.fr/1994GRE10177.
Повний текст джерелаАнотація:
Recemment, deux genes (nuo8, nuo9) de la bacterie photosynthetique rhodobacter capsulatus, codant des proteines analogues aux sous-unites nd1 et tyky de la nadh:ubiquinone oxydoreductase bovine (complexe l) ont ete clones. Une mini-banque d'adn genomique de la bacterie r. Capsulatus a ete construite dans le vecteur lamdagem-11 pour explorer les regions de l'adn adjacentes aux genes nuo8 et nuo9. Le dechiffrage de la sequence d'un fragment d'adn de 4. 915 pb, localise a portee immediate du gene nuo9, a permis de mettre en evidence 4 genes (nuo10, nuo11, nuo12, nuo13) codant des proteines hydrophobes respectivement analogues aux sous-unites nd6, nd4l, nd5 et nd4 du complexe l mitochondrial. Des souches mutantes de r. Capsulatus ont ete obtenues par insertion d'une cassette de resistance a la kanamycine dans les genes nuo8 et nuo12. Ces mutations retentissent sur le developpement de la bacterie: le developpement aerobie est fortement ralenti, le developpement photoheterotrophique necessite du co#2, les bacteries ne se developpent pas en photoautotrophie. La caracterisation polarographique et biochimique des souches mutantes montre l'absence totale d'activite nadh:ubiquinone oxydoreductase. Les spectres rpe, realises sur les membranes des souches mutantes reduites par le dithionite montrent l'absence des signatures caracteristiques des centres fe-s du complexe l de la bacterie. Ces resultats demontrent que le locus nuo de r. Capsulatus, code pour la nadh:ubiquinone oxydoreductase de la bacterie. La destruction de l'un ou l'autre des genes nuo8 et nuo12 entraine l'absence d'assemblage du complexe l dans la membrane bacterienne. Le retentissement des mutations sur le developpement bacterien est attribue a des perturbations de la balance redox
45
McGovern, Donna. "Salvinorin A: Fragment Synthesis and Modeling Studies." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1862.
Повний текст джерелаАнотація:
Salvinorin A is a non-nitrogenous, selective kappa opioid receptor agonist with potent hallucinogenic properties. Because Salvinorin A has no basic nitrogen, it does not readily adhere to the “message-address” concept of selectivity for the opioid receptors. Therefore, a better understanding of how salvinorin A and its analogs interact with the kappa opioid receptor may shed some light on how salvinorin A obtains its potency and selectivity. The structure-affinity relationships (SAFIR) of salvinorin A and its analogs along with a discussion of the selectivity of the opioid receptors, is presented. A fragment of salvinorin A, methyl-3-acetoxy-4-oxocyclohexanecarboxylate, was synthesized to determine if the B, C and D rings are or are not necessary for binding to the opioid receptors. The fragment was found not to bind to the kappa, delta or mu receptor which reinforces the importance of the B, C and D rings in the binding of salvinorin A to the kappa opioid receptor. Homology models of the kappa, delta and mu opioid receptors were constructed based on inactive bovine rhodopsin, light-activated bovine rhodopsin and the human beta-2 adrenergic receptors. The program MODELLER was also used to construct the kappa opioid receptor. Two comparative molecular field analysis (CoMFA) studies are then presented which compared three different types of alignment methods. The alignment methods employed included a receptor-docked alignment in which the salvinorin A analogs were docked into a model of the kappa opioid receptor using the program GOLD. The docked poses for this alignment were chosen based on their similarity to our postulated model of salvinorin A in the kappa opioid receptor. In our model the furan oxygen forms hydrogen bonds with Q115(2.60) and Y320(7.43), the methoxy oxygen of the C-4 position ester group may form a hydrogen bond with Y312(7.35) and the methyl group of the C-2 position acetoxy moiety forms a hydrophobic interaction with Y313(7.36). These interactions are consistent with mutagenesis studies. The other alignment methods employed were a FlexS alignment and a realignment of the receptor-docked poses using the Fit Atoms function within SYBYL. Only the receptor-docked alignment method resulted in robust and predictive CoMFA models which indicates that the analogs may bind to the kappa opioid receptor in a similar but non-identical way. In addition, information from the CoMFA models based on the receptor-docked alignment led to a postulated binding mode for a set of amine analogs of salvinorin A which were not part of the original data set. Docking studies have the positively charged C-2 position amine group interacting with E209(XL2.49) while the furan oxygen and C-4 position ester group interacts with the same residues as in our model of salvinorin A in the kappa opioid receptor. The studies presented here not only support our postulated model of salvinorin A binding to the kappa opioid receptor but may also explain the trend of the beta epimers of the amine analogs to have a higher affinity than the corresponding alpha epimers. Site-directed mutagenesis studies could provide data to support or refute the postulated models of the amines docked in the kappa opioid receptor presented here.
46
Dupin, André. "Le virus de la mosaique de l'aubergine : sequence de sa proteine capsidale et apports a la connaissance des tymovirus." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13180.
Повний текст джерела
47
Dyrmose, Morten. "Markets and how they work : a comparative analysis of fieldwork evidence on globalisation, corporate governance, institutional structure and competition in Russia, India and China, supported by a quantitative worldwide cross-section study of market anomalies." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3233.
Повний текст джерелаАнотація:
This thesis examines the efficacy of markets, using both quantitative and qualitative methods in a complementary way. Specifically, it starts (in Part II) by using the results from a quantitative analysis of initial public offering (IPO) underpricing as a barometer for corporate governance failure. This quantitative work identified Russia, China and India as extreme outliers. The data set used for this work was the cross-section sample of 45 countries developed by Loughran, Ritter & Rydqvist (2008). More broadly (in Part III), the thesis takes the lead of the quantitative evidence to examine, in a qualitative framework, possible sources of corporate governance failure in China, India and Russia. This was done categorically, under the headings of Globalisation, Corporate Governance, Institutional Structure and Competitive Strategy. Data were gathered by eldwork in China, India and Russia, and these findings were then benchmarked against findings from further fieldwork in the United Kingdom. This created a unique 56,000 word database, which was used for both cross-site and within-site analysis. This indicates how both unique attributes (e.g. rule of law, transparency, regulation, etc.), and common attributes (e.g. transition from a socialist/Marxist regime, market immaturity, asymmetric information etc.), combine to explain the different morphologies of corporate governance in these three countries. The quantitative analysis (Part II) consists of exploratory data analysis (EDA) and econometric work. The exploratory data analysis establishes, through graphical means and regression techniques, a negative correlation between IPO underpricing and globalisation (as measured by the KOF index, see Dreher, 2006). Building on this, the subsequent econometric modelling suggests that economic, demographic and institutional factors are all significant determinants of IPO underpricing. The qualitative analysis carried out in Part III of the thesis, builds on and extends the quantitative analysis of Part II. This is consistent with the multiple method approach, which combines both quantitative and qualitative analysis to achieve a synthesis of findings. The qualitative analysis uses evidence from semi-structured interviews with finance professionals and opinion makers, as well as evidence from additional primary and secondary sources, which was also made available through fieldwork contacts. This analysis emphasises the especial importance of board composition, information flows, the judicial system, the stock exchanges, and financial regulators for forms of corporate governance.
48
Schafer, Robin. "A Structural Analysis of Mutation." Department of Linguistics, University of Arizona (Tucson, AZ), 1988. http://hdl.handle.net/10150/227234.
Повний текст джерела
49
Probert, Shirley A. "A comparative and longitudinal analysis of the evolving relationship between the environment and the strategy, structure and performance of selected organisations in the British carpet industry 1959-1986 : a firms in sector perspective of organisational adaptation." Thesis, Aston University, 1989. http://publications.aston.ac.uk/10849/.
Повний текст джерелаАнотація:
Orthodox contingency theory links effective organisational performance to compatible relationships between the environment and organisation strategy and structure and assumes that organisations have the capacity to adapt as the environment changes. Recent contributions to the literature on organisation theory claim that the key to effective performance is effective adaptation which in turn requires the simultaneous reconciliation of efficiency and innovation which is afforded by an unique environment-organisation configuration. The literature on organisation theory recognises the continuing confusion caused by the fragmented and often conflicting results from cross-sectional studies. Although the case is made for longitudinal studies which comprehensively describe the evolving relationship between the environment and the organisation there is little to suggest how such studies should be executed in practice. Typically the choice is between the approaches of the historicised case study and statistical analysis of large populations which examine the relationship between environment and organisation strategy and/or structure and ignore the product-process relationship. This study combines the historicised case study and the multi-variable and ordinal scale approach of statistical analysis to construct an analytical framework which tracks and exposes the environment-organisation-performance relationship over time. The framework examines changes in the environment, strategy and structure and uniquely includes an assessment of the organisation's product-process relationship and its contribution to organisational efficiency and innovation. The analytical framework is applied to examine the evolving environment-organisation relationship of two organisations in the same industry over the same twenty-five year period to provide a sector perspective of organisational adaptation. The findings demonstrate the significance of the environment-organisation configuration to the scope and frequency of adaptation and suggest that the level of sector homogeneity may be linked to the level of product-process standardisation.
50
Hernandez, Javier. "Financial services and social structures : a comparative analysis." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10565.
Повний текст джерелаАнотація:
Although there is an increasing interest in social sciences amongst policy makers in financial services and investment organisations, not enough is known about the way financial organisations and activities interact with their social environments. In particular, there is a need for more research into the way financial activities are integrated into broader social structures. This thesis will report on a comparative study analysing the practices of financial organisations and their employees in two very different social environments: the UK and Chile. From 38 in-depth interviews with financial practitioners in London, Edinburgh and Santiago de Chile about their job trajectories and experiences, it was possible to analyse the practices of financial organisations in the UK and Chile, with an emphasis on the way they interact with global financial trends and local distributions of power and resources. A sociological account of organisational processes such as recruitment, socialisation, staff allocation, promotion and organisation of work within firms in these countries allowed for description and analysis of the way firms’ practices are related to their social (structural, symbolic and institutional) contexts. The research shows that Chile’s position in the global financial market and local distribution of resources encourage more traditional organisational practices, especially in terms of recruitment, socialisation, staff allocation and promotion, as well as activities performed and the way services are provided. In the UK, on the other hand, all of the above-mentioned processes are more technical, formally designed and competitive.