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1

Dahbi, Houssem. "Ρarametric estimatiοn fοr a class οf multidimensiοnal affine prοcesses". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR089.

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Cette thèse traite l'inférence statistique de quelques processus de diffusion affine dans \( \R^m_+ \times \R^n \), avec m,n\in\N. Cette sous-classe de diffusions, notée par \textit{AD}(m,n), est appliquée à la tarification des options sur obligations et des actions, ce qui est illustré pour les modèles de Vasicek, Cox-Ingersoll-Ross (CIR) et Heston. Dans cette thèse, nous considérons deux différents modèles: le premier lorsque \( m = 1 \) et \( n \in \mathbb{N} \) et le deuxième lorsque \( m = 2 \) et \( n = 1 \). Pour le modèle \mathit{AD}(1, n), nous introduisons, au Chapitre 2, un résultat de classification où nous distinguons trois cas différents : sous-critique, critique et surcritique. Ensuite, nous étudions la stationnarité et l'ergodicité de sa solution sous certaines hypothèses sur les paramètres du drift. Pour le problème d'estimation paramétrique, nous utilisons deux méthodes différentes : l'estimation par maximum de vraisemblance (MLE) et l'estimation des moindres carrés conditionnels (CLSE). Au Chapitre 2, nous présentons l'estimateur obtenu par la méthode MLE basée sur des observations en temps continu et nous étudions sa consistance et son comportement asymptotique dans des cas ergodiques et non-ergodiques particuliers. Au Chapitre 3, nous présentons l'estimateur obtenu par la méthode CLSE basée sur des observations en temps continu puis discret avec haute fréquence et horizon infini et nous étudions sa consistance et son comportement asymptotique dans des cas ergodiques et non-ergodiques particuliers. Il est à noter ici que nous obtenons les mêmes résultats asymptotiques que dans le cas continu sous des hypothèses supplémentaires sur le pas de discrétisation \( \Delta_N \). Au Chapitre 4, nous étudions le modèle \mathit{AD}(2, 1), également appelé modèle de double Heston. Dans un premier temps, nous introduisons sa classification suivant les cas sous-critique, critique et surcritique. Dans un second temps, nous établissons les théorèmes de stationnarité et d'ergodicité y associés. Dans la partie statistique de ce chapitre, nous étudions les estimateurs par la méthode MLE et la méthode CLSE du modèle de double Heston en se basant sur des observations en temps continu dans le cas ergodique et nous introduisons les théorèmes de consistance et de normalité asymptotique pour chaque estimateur obtenu
This thesis deals with statistical inference of some particular affine diffusion processes in the state space \R_+^m\times\R^n, where m,n\in\N. Such subclass of diffusions, denoted by \mathit{AD}(m,n), is applied to the pricing of bond and stock options, which is illustrated for the Vasicek, Cox-Ingersoll-Ross (CIR) and Heston models. In this thesis, we consider two different cases : the first one is when m=1 and n\in\N and the second one is when m=2 and n=1. For the \mathit{AD}(1,n) model, we introduce, in Chapter 2, a classification result where we distinguish three different cases : subcritical, critical and supercritical. Then, we study the stationarity and the ergodicity of its solution under some assumptions on the drift parameters. For the parameter estimation problem, we use two different methods: the maximum likelihood estimation (MLE) and the conditional least squares estimation (CLSE). In Chapter 2, we present the estimator obtained by the MLE method based on continuous time observations and we study its consistency and its asymptotic behavior in ergodic and particular non-ergodic cases. In Chapter 3, we present the estimator obtained by the CLSE method based on continuous then discrete time observations with high frequency and infinite horizon and we study its consistency and its asymptotic behavior in ergodic and particular non-ergodic cases. It is worth to note here that we obtain the same asymptotic results in both discrete and continuous sets under additional assumptions on the discretization step \Delta_N. In Chapter 4, we study the \mathit{AD}(2,1) model, called also double Heston model, we introduce first its classification with respect to subcritical, critical and supercritical case and we establish the relative stationarity and ergodicity theorems. In the statistical part of this chapter, we study the MLE and the CLSE of the ergodic double Heston model based on continuous time observations and we introduce its consistency and asymtotic normality theorems for each estimation method
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2

Merlugo, Liara. "Análise cromatográfica, constituição química em alcaloides e avaliação do potencial hipotensor de extratos vegetais obtidos de espécies de Erythrina." Universidade Federal do Pampa, 2015. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/282.

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O gênero Erythrina está presente mundialmente nas regiões tropicais e subtropicais. Estudos fitoquímicos utilizando vários órgãos dessas plantas, demostraram a presença de alcaloides, flavonoides, pterocarpanos e triterpenóides. Várias espécies são encontradas no Brasil, dentre elas Erythrina falcata e Erythrina crista-galli, conhecidas popularmente como “corticeira” e utilizadas medicinalmente devido à ação sedativa, ansiolítica, anti-inflamatória e antihipertensiva. Este trabalho objetivou estudar a composição química de extratos vegetais obtidos de folhas de E. falcata e E. crista-galli e ainda, avaliar o potencial hipotensor in vivo de extratos de E. falcata. Inicialmente, após coleta do material, as folhas foram selecionadas, submetidas à secagem e trituradas. Então, foram submetidas à extração por maceração exaustiva utilizando etanol 40% (v/v) e por infusão utilizando água a 100 °C. Para a caracterização em termos de fenólicos totais e conteúdo de flavonoides, os extratos foram quantificados por espectrofotometria. Para o ensaio cromatográfico, os extratos foram analisados por CLAE em sistema de fase reversa, com fase móvel consistindo de acetonitrila:água em eluição por gradiente e fluxo de 1,0 mL/min. Para a análise por CLUEESI- MS, a fase móvel foi composta de mistura de acetonitrila:metanol (4:1) e ácido fórmico pH 3,0, com eluição por gradiente e fluxo de 0,2 mL/min. A detecção por espectrometria de massas foi conduzida a partir das seguintes condições: N2 como nebulizante; energia de colição 4.0 eV; temperatura da fonte do eletrospray e do gás de solvatação 100°C e 120°C, respectivamente; voltagem do capilar 3000V; voltagem do cone 40V. Os espectros de massas foram obtidos na faixa de m/z 200-800. A avaliação dos efeitos hemodinâmicos foi realizadaem ratos wistar normotensos, anestesiados com uretana (1,4 mg/Kg), via canulação da artéria carótida (para a verificação da PAS, PAD e FC) e veia jugular (para administração do extratose drogas). A avaliação do potencial hipotensor da E. falcata foi investigada através da realização de uma curva crescente de administração dos extratos e os possíveis mecanismos de ação envolvidos foram analisados através da administração de diferentes drogas sendo elas: L-NAME (30 mg/kg); losartana (10 mg/Kg); hexametônio (20mg/Kg) e propranolol (5mg/kg). Os teores de fenólicos totais para E. falcata e E. crista-galli estiveram na faixa de 1,3193 – 1,4989 mgEAG/mL para os extratos obtidos por maceração e de 0,8771 – 0,9506 mgEAG/mL para as infusões. Em flavonoides totais, os conteúdos estiveram na faixa de 7,7829 – 8,1976 ER mg/g para os extratos obtidos por maceração e 9,3471 – 10,4765 ER mg/g para as infusões. Na determinação por CLUE-MS, os dados de íon molecular e fragmentos de massa indicaram a composição predominante em alcaloides, sugerindo-se os componentes erythristemine, 11β-methoxyglucoerysodine, erysothiopine, 11β- hydroxyerysodine–glicose e 11-hydroxyerysotinone-ramnosídeo. O extrato aquoso da E. falcata mostrou-se um potente hipotensor dose-dependente, causando uma queda na PAS de 23 a 35% e na PAD de 32 a 49% para ambos os extratos estudados, sem influenciar a FC, podendo este efeito estar relacionado com a via dos receptores β-adrenérgicos.
The genus Erythrina is present worldwide in tropical and subtropical regions. Phytochemical studies using various organs of these plants demonstrated the presence of alkaloids, flavonoids, pterocarpans and triterpenoids. Several species are found in Brazil, among them Erythrina falcata and Erythrina crista-galli, which are popularly known as “corticeira” and. used medicinally due to it action as sedative, anxiolytic, anti-inflammatory and antihypertensive. The present study aimed to investigate the chemical composition of extracts obtained from leaves of E. falcata and E. crista-galli, and still, to evaluate the hypotensive potential in vivo of E. falcata extracts. Initially, after collection of material plant, the leaves were selected, submitted to dryness and powdered. Then, submitted to extration by exhaustive maceration using ethanol 40% (v/v) and by infusion using water at 100 °C. For characterization in terms of phenolics and flavonoid content, the extracts were quantified by spectrophotometry. For chromatographic assay, the extracts were analysed by HPLC in reversed phase system, with a mobile phase consisting of acetonitrile:water in gradient elution and flow rate of 1.0 mL/min. For analysis by UPLC-ESI-MS, the mobile phase consisted in a mixture of acetonitrile:methanol (4:1) and 0.1% formic acid pH 3.0, with a elution by gradient and flow rate of 0.2 mL/min. The MS detection was performed following the conditions: N2 as nebulizing; collision energy 4.0 eV; temperature of electrospray source and desolvation gas 100°C and 120°C, respectively; capillary voltage 3000V; sample cone 40V. Mass spectra were recorded in the range of m/z 200-800. The evaluation of the hemodynamic effects was performed in normotensive Wistar rats, anesthetized with urethane (1.4 mg/kg) by cannulation of the carotid artery (for verification of SBP, DBP and HR) and jugular vein (for administration of the extracts and drugs). The hypotensive potential of E. falcata was investigated by conducting a growing curve administration of the extracts and the possible mechanisms involved were analyzed by administering different drugs such as: L-NAME (30 mg/kg); losartan (10 mg/kg); hexamethonium (20 mg/kg) and propranolol (5 mg/kg). The total phenolics content for E. falcata and E. crista-galli was from 1.3193 to 1.4989 mgGAE/mL for maceration and 0.8771 to 0.9506 mgGAE/mL for infusions. In total flavonoid, the content was from 7.7829 to 8.1976 mg RE/g for maceration and 9.3471 to 10.4765 RE mg/g for infusions. The molecular ions and mass fragments obtained by UPLCMS indicated the predominant composition in alkaloids, suggesting the components erythristemine, 11β-methoxyglucoerysodine, erysothiopine, 11β-hydroxyerysodine-glucose and 11-hydroxyerysotinone-rhamnoside. The aqueous extract of E. falcata showed to be a potent dose-dependent hypotensive, decreasing the SBP in 23 to 35% and DBP in 32 to 49% for both extracts, without influence in HR, and this effect may be due to the route of β- adrenergic receptors.
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3

Silva, Gabriela Ribeiro. "Estudo de alcaloides dos frutos de Passiflora alata e de Passiflora edulis por SBSE, CLAE-Flu e identificação por CLUE-EM." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-17082015-143533/.

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O maracujá, nome popular atribuído ao fruto das diversas espécies do gênero Passiflora, da família Passifloraceae, é amplamente comercializado e consumido no mundo, sendo o Brasil um dos maiores produtores do fruto. Alguns estudos apontam possível toxicidade relacionada às espécies de Passiflora, principalmente P. incarnata. No entanto, há pouco conhecimento acerca das espécies P. edulis e P. alata, sobretudo em relação à polpa e sementes. Os extratos da polpa e das sementes dos frutos dessas duas espécies de \"maracujá\", Passiflora alata e Passiflora edulis, foram estudados com o objetivo de identificar alcaloides harmânicos, pelo preparo das amostras por extração por sorção em barra magnética recoberta com polidimetilsiloxano (SBSE-PDMS) e SBSE recoberta com polietilenoglicol silicone (SBSE-EG Silicone) e análise por cromatografia líquida de alta eficiência com detector por fluorescência (CLAE-Flu) e cromatografia líquida de ultra eficiência acoplada à espectrometria de massas sequencial (CLUE-EM/EM). A análise dos alcaloides harmana e harmina nos extratos da polpa de P. alata foi feita por meio do método de adição de padrão e mostrou menor quantidade destes alcaloides, em comparação com os resultados da análise dos extratos da polpa dos frutos de P. edulis, no trabalho de Pereira e colaboradores. As análises CLUE-EM e CLUE-EM/EM possibilitaram a identificação dos alcaloides nos extratos: nas sementes de P. alata, os alcaloides harmana, harmina, harmol, harmalol e harmalina foram identificados, enquanto que na polpa, harmana e harmina tiveram a confirmação da sua presença. Nos extratos da polpa dos frutos de P. edulis observou-se os alcaloides harmana, harmina e harmalina. E nas sementes de P. edulis harmina foi encontrada, porém há indícios da presença de harmana. A literatura sobre as barras de SBSE-EG Silicone Twister&®; não relata nenhum estudo relacionado ao seu uso para extração e concentração de alcaloides harmânicos nos extratos de P. alata e P. edulis. Por isso foi proposto inicialmente a aplicação do planejamento fatorial fracionário para otimização do método de extração, utilizando os padrões comerciais dos alcaloides harmana e harmina. O planejamento experimental revelou as variáveis principais e seus níveis de importância, e a partir destes resultados foi realizado o estudo cinético dos tempos de extração e de dessorção das barras de SBSE-EG Silicone. Porém, os resultados mostraram que as barras de SBSE-EG Silicone não são adequadas para a extração dos alcaloides harmana e harmina, uma vez que a recuperação obtida foi baixa, na ordem de 30%.
\"Maracujá\" is the popular name given to the fruit of several species of Passiflora genus, from Passifloraceae family, it is widely commercialized and consumed around the world, and Brazil is one of the largest producers of this fruit. Some studies pointed out the possible toxicity related to Passiflora species, mainly P. incarnata. Although, there is a lack of knowledge about the P. edulis and P. alata species, especially with regards to the pulp and seeds. The extracts of pulp and seeds from the \"maracujá\" species Passiflora alata and Passiflora edulis, were studied in order to identify harman alkaloids. The samples were prepared by extraction with sorptive stir bar coated with polydimethylsiloxane (SBSE-PDMS) and SBSE coated with polyethylene glycol silicon (SBSE-EG Silicone). The samples were analyzed by high performance liquid chromatography with fluorescence detector (HPLC-Flu), and ultra-high pressure liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). Harmane and harmine alkaloids in P. alata pulp extracts were analyzed using the standard addition method and the results showed a lower amount of these alkaloids, compared with the test results for the extracts from the P. edulis pulp in the work of Pereira et al. UHPLC-MS and UHPLC-MS/MS analysis enabled to identify the alkaloids amount present in the extracts. In the P. alata seeds extract the following alkaloids were identified harmane, harmine, harmol, harmalol and harmaline, while in the pulp extract, harmane and harmine were confirmed. In the extracts of P. edulis pulp the alkaloids identified were harmane, harmine and harmaline. And in the P. edulis seeds extract the harmine alkaloid was found, some indications of the presence of harmana were observed. The literature about SBSE-EG Silicone Twister® bars reports no study related to their use for extraction and concentration of harman alkaloids in P. alata and P. edulis. Thus, it was initially proposed the application of fractional factorial design to optimize the extraction method using commercial standards of harmane and harmine alkaloids. The experimental design revealed the main variables and their importance levels, and from these results kinetic studies were performed for the extraction and desorption times of SBSE-EG Silicone bars. However, the results showed SBSE-EG Silicone bars are not suitable for the extraction of harmane and harmine alkaloids, since the recovery obtained was low, on the order of 30%.
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Brou, Philip Edmond III. "Close encounters." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1413285876.

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Jennings, LaShay. "Close Reading." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/3450.

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Gagnon, Donald P. "Close to home." Master's thesis, University of Central Florida, 1994. http://digital.library.ucf.edu/cdm/ref/collection/RTD/id/24547.

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7

O'Connor, Patricia. "Very close relationships." Thesis, Royal Holloway, University of London, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320140.

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Risha, Zachary Joseph. "Interactive Close Reading." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/77914.

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Over the past two decades, the readership of poetry has declined to the point that the art form is seldom engaged with by the public. I argue that reading poetry requires a skillset that must be learned, practiced, and refined. While close reading is traditionally trained in college classrooms, such spaces cannot reach broad audiences. To address this dearth, I have developed a web app that applies interactive learning strategies, through a series of exercises, to cultivate expert reading practices in novice users. Close Reading will guide users through poems by Robert Frost. With each poem, users will progress through exercises grounded in the practices of expert readers. For instance, users will block poems into sections to allow a chunking of the material, slowing down novice reading speeds. Another exercise cognitively models the act of reading by displaying the sequential thoughts of a reader making sense of a work. Furthermore, Socratic questioning will attempt to stimulate an internal dialogue to foster focus and interpretation. These exercises will build on one another and attempt to replicate pedagogical processes observed in the classroom. Performing these pedagogical exercises will provide a resource for developing the skillset necessary for poetry appreciation. This ambitious digital humanities project experiments with a new venue for pedagogy and poetry, promoting an engagement with the public frequently neglected in academic work.
Master of Arts
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9

Bright, Cayleigh. "Close to home." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/7765.

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Located in the college novel tradition, Close to Home explores a number of the themes common to the sub-genre, specifically the ennui of university students from a wealthy background. The story's characters have an excess of money, privilege and leisure time, which leads to boredom and ultimate tragedy. The protagonist, Faye, epitomises the stereotype of a spoiled Cape Town girl- a personality that turns out to have a lot in common with the magnetic but ultimately dangerous characters of some of the best-known college novels.
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Chiaradia, Mariza Campagnolli. "Desenvolvimento, validação e aplicação de metodos para analise multrirresidual de agrotoxicos em suco de laranja e tangerina utilizando CLAE-DAD, CL-EM-EM E CLUE-DAD." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250537.

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Orientador: Isabel Cristina Sales Fontes Jardim
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica
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Resumo: O Brasil é o maior produtor mundial de citrus e o principal exportador de suco. Dentre as espécies cultivadas no Brasil, há a predominância de laranjas Pera e tangerinas Murcote. Porém, os agricultores brasileiros tem enfrentado a incidência de várias pragas agrícolas na cultura de citrus, de forma que, para manter a produção e a qualidade, tem sido necessário aplicar agrotóxicos de forma constante e cada vez maior. Por outro lado, devido ao risco resultante da exposição dos consumidores aos resíduos de agrotóxicos presentes nos alimentos, agencias governamentais reguladoras tem estabelecido limites máximos de resíduos (LMR) para todos os agrotóxicos. Neste contexto, três métodos para a determinação de resíduos dos principais agrotóxicos (aldicarbe, difenoconazol, diflubenzurom, diurom, imidacloprido e tiofanato metílico) aplicados no cultivo de laranjas Pera e tangerinas Murcote foram desenvolvidos e validados. Vários métodos de preparo de amostras foram avaliados e o método QuEChERS foi o que se mostrou mais eficiente, rápido e simples. Foram utilizadas diferentes técnicas cromatográficas para a validação do método: cromatografia líquida de alta eficiência com detecção por arranjo de diodos (CLAE-DAD), cromatografia líquida acoplada a espectrometria de massas em série (CL-EM-EM) e cromatografia líquida de ultra eficiência com detecção por arranjo de diodos (CLUE-DAD). Os parâmetros analíticos mostraram que o método proposto extrai de maneira satisfatória os agrotóxicos das matrizes, permitindo sua detecção por todas as técnicas analíticas utilizadas. Entretanto, devido a complexidade da matriz estudada foi necessário fazer a calibração na matriz. As recuperações obtidas foram de 79 a 124% com CLAE-DAD, de 83 a 119% com CL-EM-EM e de 78 a 113% com CLUEDAD, com coeficientes de variação menores que 15% para todas as tecnicas cromatograficas. Os limites de quantificacao obtidos mostraram que os métodos podem ser utilizados para a detecção dos agrotóxicos em concentrações abaixo dos LMR estabelecidos pela legislação brasileira e dos EUA. Com a CLUE-DAD obtiveram-se os menores tempos de análise, 7 min, e a CL-EM-EM foi a técnica cromatografica mais seletiva e com a melhor detectabilidade (4 mg L) utilizada neste trabalho. O método foi aplicado a amostras coletadas no comercio da cidade de Campinas-SP e o agrotóxico encontrado com maior frequência foi o imidacloprido, mas em concentrações abaixo dos LMR
Abstract: Brazil is the world's largest producer of oranges and the largest exporter of juice. Among the species grown in Brazil, there is a predominance of Pera oranges and Murcote tangerines. Brazilian agriculturist have faced several diseases during orange and tangerine cultivation that demand constant and even expensive applications of pesticides to mantain production and quality. On the other hand, because of potential health risk to the consumers, resulting from acute and/or chronic dietary exposure, government regulatory agencies have established maximum residue limits (MLR) for all the pesticides. Thus, this work developed and validated three methods to determine the main pesticides applied to Pera orange and Murcote tangerine cultivation in Brazil: aldicarb, difenoconazole, diflubenzuron, diuron, imidacloprid and thiophanate-methyl. Several sample preparation methods were evaluated and the QuEChERS method was the more suitable, rapid and simplest extraction method for the matrices studied. The methods were validated using different chromatographic techniques: high performance liquid chromatography ¿ diode array detection (HPLC-DAD), liquid chromatography ¿ tandem mass spectrometry (LC-MSMS) and ultra-performance liquid chromatography ¿ diode array detection (UPLC-DAD). The analytical parameters demonstrate that the proposed methodologies satisfactorily extract the pesticides from the matrices, allowing detection using all the quantification techniques employed. Because of the complexity of the matrices studied, it was necessary to employ matrix-matched calibration. When using HPLC-DAD recoveries of 79 to 124% were obtained, with LC-MS-MS the recoveries were 83 to 119% and when using UPLC they were 78 to 113%, with coefficients of variation below to 15% for all chromatographic techniques. These limits of quantification show that the methods developed can be used to detect these pesticides at concentrations below the MRL established by Brazilian and USA legislation. UPLC-DAD had a more rapid analysis time, 7 min, and LC-MS-MS had the best selectivity and detectivity (4 mg L). The methods were applied to samples collected in markets of Campinas city, and the pesticide most frequently found was imidacloprid, with concentrations well below the listed MRL
Doutorado
Quimica Analitica
Doutor em Ciências
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Santos, Marí Castro. "Estudo de Determinação Cromatográfica e Avaliação das Atividades Antifúngica e Anti-hipertensiva de Extratos Obtidos de Cuphea Glutinosa Cham. & Schltdl (lythraceae)." Universidade Federal do Pampa, 2014. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/235.

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O gênero Cuphea, popularmente conhecido no Brasil por “sete-sangrias”, tem seu uso medicinal reconhecido devido aos efeitos diurético, hipotensor e cardioprotetor. No sul do Brasil, em região característica do bioma Pampa, foi encontrada a espécie Cuphea glutinosa Cham. & Schltdl. Embora o uso popular, esta espécie é pouco descrita na literatura. O presente trabalho tem como objetivos o estudo da composição química dos extratos de C. glutinosa e a avaliação das atividades antifúngica e anti-hipertensiva. O material vegetal foi coletado na cidade de Uruguaiana (RS, Brasil), identificado e depositado em herbário. Após secagem e trituração do material vegetal, foram obtidos os extratos hidroetanólicos através de maceração exaustiva com etanol 40% (v/v) para folhas e etanol 70% (v/v) para raízes. Para a infusão, utilizou-se água a 80oC. As análises cromatográficas foram realizadas em equipamento cromatógrafo a líquido Prominence Shimadzu, em técnica por CLAE e CLUE. Utilizou-se sistema de fase reversa, eluição por gradiente com fase móvel composta por acetonitrila:metanol (4:1) e ácido fórmico 0,1% pH 3,0, coluna C18 analítica e fast, e detecção por UV-DAD e ESI-MS. Os teores de polifenóis totais e de flavonóides foram determinados por método colorimétrico, seguindo metodologia padronizada. A atividade antifúngica in vitro foi realizada utilizando o método de microdiluição em caldo, determinando-se a CIM, in-vitro, contra diferentes isolados clínicos. Para avaliação do potencial anti-hipertensivo in vivo, foram realizadas medições da pressão sanguínea pelo método de monitoramento hemodinâmico invasivo, através da inserção de cateter na artéria carótida. Os resultados de teor de fenólicos totais indicaram predominância destes componentes em extratos obtidos de folhas e por maceração, conforme os valores obtidos: 1,8501 mg EAG/mL (folhas) e 0,8467 mg EAG/mL (raízes) para infusão, e 3,7284 mgEAG/mL (folhas) e 2,6266 mg EAG/mL (raízes) para maceração. Quanto ao teor de flavonóides, os resultados quantitativos foram: 7,0959 mg/g (folhas) e 0,5664 mg/g (raízes) para a infusão, e 7,9511 mg/g (folhas) e 0,5994 mg/g (raízes) para maceração. Na análise cromatográfica, os extratos obtidos das folhas de C. glutinosa apresentaram picos cromatográficos bem separados, em perfil reprodutível. Na determinação por CLUE-MS, os dados de íon molecular e fragmentos de massa indicaram a composição predominante em flavonóides, sugerindo-se os componentes quercetina-3-O-glicosídeo, quercetina-3- arabinosídeo, quercetina-3-glicuronídeo, isoramnetina e quercetina-5-O-β-glicopiranosídeo. Para o potencial antifúngico, os extratos das folhas e raízes apresentaram atividade in vitro contra Candida parapsilosis, Candida tropicalis e Trichosporon asahii, com CIM variando na faixa de 1,9-62,5 μg/mL. Nos testes hemodinâmicos realizados, os extratos das folhas não apresentaram efeito significativo sobre a pressão arterial. A identificação dos componentes em C. glutinosa, derivados de quercetina, torna promissora novas investigações a fim de aprofundar o conhecimento a respeito desta espécie, em especial na busca de respostas para a relatada ação anti-hipertensiva.
The Cuphea genus, popularly known in Brazil as "sete-sangrias", is used traditionally due the diuretic, hypotensive and cardioprotective effects. In southern Brazil, in characteristic region of Pampa biome, it was found the species Cuphea glutinosa Cham. & Schltdl. Although used popularly, this species is few reported in the literature. The present work aimed to study the chemical composition of extracts from C. glutinosa and to evaluate the antifungal and anti -hypertensive activities. The plant material was collected in the city of Uruguaiana (RS, Brazil), identified and deposited in a herbarium. After dryness and milling, the hydroethanolic extracts were obtained through exhaustive maceration using ethanol 40% (v/v) for leaves and ethanol 70% (v/v) for roots. The infusions were prepared using water at 80 °C. The chromatographic analyses were performed in liquid chromatography Prominence Shimadzu, for HPLC and UPLC assays. The method was conducted using reverse phase system, gradient elution with mobile phase composed by acetonitrile:methanol (4:1) and formic acid 0.1% pH 3.0, C18 analytical and fast column, and detection by UV-DAD and MS. The polyphenols and flavonoids contents were determined by colorimetric method. The in vitro antifungal activity was conducted by using the broth microdilution method, determining the MIC against different clinical isolates. For evaluation of in vivo anti-hypertensive potential, the blood pressure was measured by the method of invasive hemodynamic monitoring, through of insertion the catheter into the carotid artery. The results of phenolic content indicated the high concentration of these compounds in leaves extracts obtained by maceration: 1.8501 mgEAG/mL (leaves) and 0.8467 mgEAG/mL (roots) for infusion, and 3.7284 mgEAG/mL (leaves) and 2.6266 mgEAG/mL (roots) for maceration. For flavonoids, the contents were: 7.0959 mg/g (leaves) and 0.5664 mg/g (roots) for infusion, and 7.9511 mg/g (leaves) and 0.5994mg/g (roots) for maceration. In the chromatographic analyses, the leaf extracts from C. glutinosa presented chromatographic peaks well separated and reproducible. In the determination by UPLC-MS, the molecular ion and mass fragments indicated the predominant composition in flavonoids, suggesting the compounds quercetin-3- O-glucoside, quercetin-3-arabinoside, quercetin-3-glucuronide, isorhamnetin and quercetin-5- O-β-glucopiranoside. For the antifungal potential, the leaf and roots extracts presented activity against Candida parapsilosis, Candida tropicalis e Trichosporon asahii, with MIC values ranging 1,9-62,5 μg/mL. In the hemodynamic tests performed, the leaves extracts did not present significant effect in the arterial pressure, although a tendency in pressure reduction could be observed. The identification of quercetin derivatives in C. glutinosa becomes promisor further investigations about this species, mainly in respect to the anti-hypertensive action.
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12

Neubauer, Catherine E. "How close is close enough? : temporal matching between visual and tactile signaling." Honors in the Major Thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1121.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.
Bachelors
Sciences
Psychology
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13

Almeida, Érika Vieira de. "Desenvolvimento e validação de metodologia para radiofármacos de Tecnécio- 99m empregando cromatografia líquida de alta eficiência (CLAE)." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-24092009-142057/.

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Radiofármacos são compostos, sem ação farmacológica, que têm na sua composição um radioisótopo e são utilizados em Medicina Nuclear para diagnóstico e terapia de várias doenças. No presente trabalho, foi feito o desenvolvimento e a validação de método analítico para análise dos radiofármacos SAH-99mTc, EC-99mTc, ECD-99mTc e Sestamibi-99mTc e algumas matérias-primas por cromatografia líquida de alta eficiência (CLAE). As análises foram realizadas em equipamento CLAE Shimadzu, modelo LC-20AT Prominence. Algumas impurezas foram identificadas pela adição de substância de referência. A validação do método foi realizada segundo os critérios da norma RE no 899/ 2003 da Agência Nacional de Vigilância Sanitária ANVISA. Os resultados dos ensaios de robustez dos métodos demonstraram que são necessários o controle das condições de fluxo, volume de amostra, pH da fase móvel e temperatura do forno. As curvas analíticas foram lineares nas faixas de concentrações analisadas, com coeficientes de correlações lineares (r2) maiores que 0,9995. Os resultados de precisão, exatidão e recuperação apresentaram valores na faixa de 0,07- 4,78%, 95,38- 106,50% e 94,40- 100,95%, respectivamente. Os limites de deteção (LD) e os limites de quantificação (LQ) variaram de 0,27 a 5,77 g mL-1 e 0,90 a 19,23 g mL-1, respectivamente. Os valores encontrados para SAH, EC, ECD e MIBI nos RL (reagente liofilizado) foram 8,95; 0,485; 0,986 e 0,974 mg L-1, respectivamente. A pureza radioquímica média para SAH-99mTc, EC-99mTc, ECD-99mTc e Sestamibi-99mTc foi (97,28 ± 0,09)%, (98,96 ± 0,03)%, (98,96 ± 0,03)% e (98,07 ± 0,01)%, respectivamente. Todos os parâmetros recomendados pela ANVISA foram avaliados e os resultados estão abaixo dos limites estabelecidos.
Radiopharmaceuticals are compounds, with no pharmacological action, which have a radioisotope in their composition and are used in Nuclear Medicine for diagnosis and therapy of several diseases. In this work, the development and validation of an analytical method for 99mTc-HSA, 99mTc-EC, 99mTc-ECD and 99mTc-Sestamibi radiopharmaceuticals and for some raw materials were carried out by high performance liquid chromatography (HPLC). The analyses were performed in a Shimadzu HPLC equipment, LC-20AT Prominence model. Some impurities were identified by the addition of a reference standard substance. Validation of the method was carried out according to the criteria defined in RE n. 899/2003 of the National Sanitary Agency (ANVISA). The results for robustness of the method showed that it is necessary to control flow rate conditions, sample volume, pH of the mobile phase and temperature of the oven. The analytical curves were linear in the concentration ranges, with linear correlation coefficients (r2) above 0.9995. The results for precision, accuracy and recovery showed values in the range of 0.07-4.78%, 95.38-106.50% and 94.40-100.95%, respectively. The detection limits (DL) and quantification limits (QL) varied from 0.27 to 5.77 g mL-1 and 0.90 to 19.23 g mL-1, respectively. The values for HAS, EC, ECD and MIBI in the lyophilized reagents (LR) were 8.95; 0.485; 0.986 and 0.974 mg L-1, respectively. The mean radiochemical purity for 99mTc-HSA, 99mTc-EC, 99mTc-ECD and 99mTc-Sestamibi was (97.28 ± 0.09)%, (98.96 ± 0.03)%, (98.96 ± 0.03)% and (98.07 ± 0.01)%, respectively. All the parameters recommended by ANVISA were evaluated and the results are below the established limits.
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Subiabre, González Juan Pablo. "Historias de trabajadores : experiencias de precariedad en Chile 2002-2013." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/136868.

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Tesis para optar al grado de Magíster en Gestión de Personas y Dinámica Organizacional
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Mediante este trabajo de investigación se busca generar un entendimiento sobre cómo las y los trabajadores de organizaciones Chilenas contemporáneas experimentan su identidad en el espacio de trabajo, buscando indagar sobre las motivaciones, anhelos y carencias que éstos vivencian en su cotidianidad. El interés en esta temática surge de la constatación de que el espacio de trabajo no sólo está acotado a las tareas funcionales que conforman el quehacer productivo, sino que también es un espacio social inter‐subjetivo en el cual juegan un rol fundamental los sentimientos, emociones, símbolos y significados que los miembros de la organización elaboran en su interior. A través del análisis crítico de historias escritas por trabajadores Chilenos se busca ahondar en cómo se vive la experiencia del trabajo desde la óptica de los propios individuos, según Sotteau‐Léomat, comprendiendo “el sentido que dan a sus actos, las lógicas que organizan sus vidas cotidianas, sus sistemas de vinculación con los otros, sus relaciones con las instituciones, y también los principios del ser y de hacer que sustentan sus prácticas y dan cuenta de sus visiones de mundo y su búsqueda de identidad social” (como se cita en Correa, 1999, pág. 2). Se considera el análisis como crítico en la medida que permite centrar la investigación en los individuos “comunes y corrientes”, alejándose de aquellos relatos sobre personas u organizaciones que resultan grandilocuentes y triunfalistas, los que si bien pueden ser muy inspiradores, resultan casos excepcionales en la práctica. El componente crítico también incorpora las dimensiones emocionales y afectivas que se suceden en el trabajo, reconociendo a los trabajadores como seres sensitivos y complejos. La exploración de las dinámicas organizacionales se realiza a través del uso de historias escritas o cuentos que fueron recopilados, seleccionados y premiados por el Comité Editorial del concurso literario “Mi Vida, Mi Trabajo”, promovido por el Ministerio del Trabajo del Gobierno de Chile. Este concurso es de carácter nacional, comienza el año 2002 y se encuentra plenamente vigente en la actualidad, convocando cada año a miles de trabajadores que envían sus escritos. Los finalistas, aparte de ser galardonados con lugares o menciones honrosas, son publicados anualmente en un libro homónimo, que se encuentra disponible en todas las bibliotecas municipales del país y que constituye la muestra para esta investigación. Se trabaja a través de una epistemología interpretativa y haciendo uso de modos narrativos de análisis de datos (Bolivar, 2002), lo que busca lograr un entendimiento fenomenológico de la identidad en el espacio de trabajo en Chile, centrándose en las subjetividades de los trabajadores y en la inter‐subjetividad de quienes componen la organización. Dicho de otra manera, con el objetivo de buscar entendimiento sobre la realidad del trabajo en Chile que experimentan la mayoría de los trabajadores “de a pie”, la exploración de las dinámicas organizacionales se realiza valorizando cada dato/historia como un fenómeno individual y único, lo que da cuenta de una organización‐en‐lamente particular y que permite, en el agregado, obtener una visión del sistema. A través del análisis se presta especial atención a aquellas características que se reiteran, que resultan coherentes con otros indicadores y que hablan de dimensiones poco conocidas o marginadas de la visión contemporánea sobre el trabajo en nuestro país. Esto va aparejado con el análisis que se hace sobre el contexto político, económico, social y normativo en el que están enmarcadas las historias que componen la muestra, las cuales fueron escritas entre el año 2002 y el 2013. El calce entre las temáticas recurrentes que emergen a través de las historias y el análisis de los cambios que ha experimentado el país durante las últimas décadas, dan como resultado un foco centrado en la temática de la Precariedad Laboral, y particularmente, una especial atención sobre las diversas formas en que la precariedad puede estar presente en los espacios de trabajo. Cabe aclarar que, lejos de buscarse el cuantificar la situación de precariedad laboral en Chile o de establecer una clasificación en base a indicadores objetivos, mediante esta investigación se pretende posibilitar la búsqueda de sentidos a partir de aquellas experiencias, es decir, se busca comprender cómo el individuo habita su propia historia laboral en los planos afectivos, emocionales y sociales, y cómo esta experiencia está mediada por aquellas formas de precariedad. Como resultado de este análisis interpretativo de los cuentos, emerge un ordenamiento original de Precariedad Laboral que permite clasificar las 75 historias ‐contenidas en 12 libros– en 5 dimensiones distintivas; Condiciones Laborales, Accidentabilidad, Ruralidad, Grupos Vulnerables y Precariedad Emocional. Luego de describir las características principales de cada una de estas dimensiones, se da paso al análisis en detalle de una historia representativa que refleja los principales atributos de cada categoría. El trabajo se estructura de la siguiente manera: En la primera sección se establecen antecedentes que permiten contextualizar las historias, entregando un panorama que permite entender los cambios políticos, económicos y normativos que se han producido en las últimas décadas y que constituyen la situación laboral actual en Chile y el entorno en el que se desenvuelven las historias. En la segunda sección se establece un marco teórico que explica en qué consiste la investigación narrativa como postura epistemológica, introduciendo algunos conceptos útiles para el entendimiento de sus potencialidades y limitaciones, ahondando en el uso de narrativas para el estudio de las organizaciones y el cómo a través de la exploración de las subjetividades de los trabajadores en rol se puede construir una imagen que dé cuenta de la realidad del sistema. En la tercera sección se fundamenta la metodología a emplear para el análisis de las historias, se explica cómo se realizó este análisis en particular y se reflexiona sobre los alcances y limitaciones de ella. Finalmente, en la cuarta sección se desarrolla el análisis de las historias en dos niveles distintivos; en el primero, se hace un recorrido general de las 75 historias que conforman la visión del mundo del trabajo contemporáneo en Chile, dando paso a un ordenamiento sobre dimensiones de Precariedad Laboral; en el segundo nivel, y con mayor grado de profundidad, se exploran historias escogidas que dan cuenta de una dimensión particular de precariedad y que resultan representativas de los conflictos que vivencian ciertos grupos de trabajadores.
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15

Paiva, Marcelo Vitor de. "Otimiza??o e valida??o de m?todos anal?ticos para a determina??o simult?nea de tuberculost?ticos (4-FDC) por CLAE/DAD e CLUE/ DAD." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13477.

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Tuberculosis is a serious disease, but curable in practically 100% of new cases, since complied the principles of modern chemotherapy. Isoniazid (ISN), Rifampicin (RIF), Pyrazinamide (PYR) and Chloride Ethambutol (ETA) are considered first line drugs in the treatment of tuberculosis, by combining the highest level of efficiency with acceptable degree of toxicity. Concerning USP 33 - NF28 (2010) the chromatography analysis to 3 of 4 drugs (ISN, PYR and RIF) last in average 15 minutes and 10 minutes more to obtain the 4th drug (ETA) using a column and mobile phase mixture different, becoming its industrial application unfavorable. Thus, many studies have being carried out to minimize this problem. An alternative would use the UFLC, which is based with the same principles of HPLC, however it uses stationary phases with particles smaller than 2 ?m. Therefore, this study goals to develop and validate new analytical methods to determine simultaneously the drugs by HPLC/DAD and UFLC/DAD. For this, a analytical screening was carried out, which verified that is necessary a gradient of mobile phase system A (acetate buffer:methanol 94:6 v/v) and B (acetate buffer:acetonitrile 55:45 v/v). Furthermore, to the development and optimization of the method in HPLC and UFLC, with achievement of the values of system suitability into the criteria limits required for both techniques, the validations have began. Standard solutions and tablets test solutions were prepared and injected into HPLC and UFLC, containing 0.008 mg/mL ISN, 0.043 mg/mL PYR, 0.030 mg.mL-1 ETA and 0.016 mg/mL RIF. The validation of analytical methods for HPLC and UFLC was carried out with the determination of specificity/selectivity, analytical curve, linearity, precision, limits of detection and quantification, accuracy and robustness. The methods were adequate for determination of 4 drugs separately without interfered with the others. Precise, due to the fact of the methods demonstrated since with the days variation, besides the repeatability, the values were into the level required by the regular agency. Linear (R> 0,99), once the methods were capable to demonstrate results directly proportional to the concentration of the analyte sample, within of specified range. Accurate, once the methods were capable to present values of variation coefficient and recovery percentage into the required limits (98 to 102%). The methods showed LOD and LOQ very low showing the high sensitivity of the methods for the four drugs. The robustness of the methods were evaluate, facing the temperature and flow changes, where they showed robustness just with the preview conditions established of temperature and flow, abrupt changes may influence with the results of methods
A tuberculose ? uma doen?a grave, por?m cur?vel em praticamente 100% dos casos novos, desde que obedecidos os princ?pios da moderna quimioterapia. S?o considerados f?rmacos de 1? linha no tratamento ? tuberculose: isoniazida, pirazinamida, etambutol e rifampicina. De acordo com USP 33 - NF28 (2010) as an?lises cromatogr?ficas para 3 dos 4 f?rmacos (isoniazida, pirazinamida e rifampicina) duram em m?dia 15 minutos e mais 10 minutos para a obten??o do 4? f?rmaco (etambutol) utilizando outra coluna, com outra mistura de fase m?vel, tornando esta aplica??o na pr?tica industrial desfavor?vel. Uma das alternativas ? utilizar o CLUE, o qual baseia-se nos mesmos princ?pios da CLAE, por?m utiliza fases estacion?rias com part?culas menores que 2 ?m. Dessa forma pretende-se com o presente estudo desenvolver e validar novos m?todos anal?ticos para determina??o simult?nea de tuberculost?ticos por CLAE/DAD e CLUE/DAD. Para isto, foi realizado um screening anal?tico, o qual verificou que ? necess?rio um gradiente de sistema de fase m?vel A (tamp?o acetato:metanol 94:6 v/v) e B (tamp?o acetato:acetonitrila 55:45 v/v). Posteriormente, ao desenvolvimento e otimiza??o do m?todo em CLAE e CLUE com a obten??o dos valores de adequabilidade do sistema dentro dos limites de aceita??es vigente para ambos as t?cnicas, as valida??es deram-se in?cio. Solu??es padr?es e solu??es testes dos comprimidos foram preparadas e injetadas no CLAE e CLUE, contendo isoniazida, pirazinamida, etambutol e rifampicina nas concentra??es de 0,008, 0,043, 0,030 e 0,016 mg.mL-1, respectivamente. A valida??o dos m?todos anal?ticos foram realizadas para: especificidade / seletividade, intervalos da curva anal?tica, linearidade, limite de detec??o, limite de quantifica??o, exatid?o, precis?o (repetibilidade, precis?o intermedi?ria) e robustez. Os m?todos foram adequados para determina??o dos 4 f?rmacos separadamente sem interfer?ncia nos demais. Precisos, devido ao fato de que os m?todos demonstraram que mesmo com varia??o de dias, al?m da repetibilidade, os valores ficaram dentro da faixa preconizada na legisla??o vigente. Lineares (R > 0,99), ou seja, os m?todos foram capazes de demonstrar que os resultados obtidos eram diretamente proporcionais ? concentra??o do analito na amostra, dentro de um intervalo especificado. Exatos, uma vez que os m?todos foram capazes de apresentar valores de coeficiente de varia??o e porcentagem de recupera??o dentro dos limites exigidos (98 a 102%). Os m?todos mostraram LD e LQ com n?veis baixos demonstrando que os m?todos possuem elevada sensibilidade aos quarto f?rmacos. A robustez foi avaliada frente ?s altera??es de temperatura e fluxo, onde os m?todos demonstraram-se robustos apenas nas condi??es previamente estabelecidas de temperatura e fluxo, altera??es bruscas podem acarretar influ?ncia nos resultados dos m?todos
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16

Moore, Catherine Venable. "Close Correspondences, Near Transmissions." The University of Montana, 2008. http://etd.lib.umt.edu/theses/available/etd-06202008-120648/.

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17

Dreifuss, Daniel. "El Psicólogo: clase 2." Universidad Peruana de Ciencias Aplicadas - UPC, 2006. http://hdl.handle.net/10757/272418.

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18

Baracco, Monsante Carlos A. "Temas Complementarios: clase 13." Universidad Peruana de Ciencias Aplicadas - UPC, 2008. http://hdl.handle.net/10757/272530.

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19

Marketing, Universidad Peruana de Ciencias Aplicadas Facultad de Administración y. "Retail Clase 2 Profesor." Universidad Peruana de Ciencias Aplicadas - UPC, 2008. http://hdl.handle.net/10757/272538.

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Baracco, Monsante Carlos A. "El Posicionamiento: clase 6." Universidad Peruana de Ciencias Aplicadas - UPC, 2008. http://hdl.handle.net/10757/272548.

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21

Witness, Weekend Lifestyle. "Close to their spirit." Witness Weekend, Lifestyle, 2013. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000736.

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22

McCormack, Meghan E. "Close to the Source." ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/1372.

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Abstract Close to the Source is comprised of a series of nonfiction vignettes about the artisan, agricultural, and culinary methods of Italy. In Close to the Source the human relationship with nature, food, and art is reexamined while a series of rich characters help bring the material to life. Through interviews, research, and first-hand experiences, the author attempts to archive fading artisan and food-related techniques and rituals. In the process, a cultural critique about the importance of the practical arts in contemporary times emerges. The thesis contains four sections: Terra/Land; Art and Artisans; Pane/Bread; and Compagnia/Company.
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23

Noli, Lazo Edgar Armando. "Deformidad dentofacial clase III." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/15670.

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Publicación a texto completo no autorizada por el autor
Una deformidad se define como una forma o postura anormal de una parte del cuerpo debido a fuerzas mecánicas no disruptivas; surge con mayor frecuencia durante la vida fetal tardía debido a fuerzas mecánicas, afectando a menudo el sistema músculo-esquelético. Las deformidades dentofaciales pueden presentarse en forma aislada y afectar sólo la mandíbula, o bien, extenderse a múltiples estructuras craneofaciales, ser unilaterales o bilaterales, o expresarse en el plano facial vertical, horizontal o transversal. El caso clínico que se muestra, presenta a un paciente de sexo masculino con una deformidad dentofacial clase III producto de una proyección horizontal de la mandíbula, tratado en el servicio de cirugía oral y maxilofacial del HNAL y servicio de ortodoncia de la Clínica de Post Grado de la UNMSM, se realiza una revisión teórica de la patología, fase pr quirúrgica, fase post quirúrgica y seguimiento de 1 año post quirúrgico. El objetivo de este trabajo es describir las características clínicas de una deformidad dentofacial clase III y presentar el manejo ortodóntico quirúrgico de acuerdo al protocolo establecido de las instituciones participantes.
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24

Vargas, Orbegoso Ernesto. "Prólogo de una clase." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/338652.

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Анотація:
Ganador (Mención Honrosa), género Comics. "XIX Juegos Florales 2014", realizado del 27 de Junio de 2014 al 14 de Julio de 2014. Universidad Peruana de Ciencias Aplicadas - UPC. Lima, Perú.
Seudónimo: kensei
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25

Plank, Carly Ann. "Close Quarters: Part One." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1524497585512082.

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26

Caycho, Cesar. "Clase Maestra Faber-Castell." Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/656819.

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27

Syrell, Ryan. "Adventures Close to Home." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4819.

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Анотація:
My work articulates experiences of intimacy and porosity with regard to domestic space. I think of these paintings as fields of interrelatedness which work to dismantle the perceived thresholds between things. The following text brings together the research of my studio practice and a survey of artists, writers, and filmmakers who have charted related spaces of the ordinary, domestic, and porous.
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28

Moreno-Sekula, Katica, and Baquerizo Hugo Zegarra. "Evaluación de la morfología condilar en patrones esqueléticos clase II y clase III." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/622961.

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Анотація:
Objetivo: Evaluar la morfología condilar en pacientes con patrón esquelético clase II y clase III. Materiales y métodos: Se evaluaron tomografías de 124 pacientes (18 a 30 años), los cuales fueron divididos en 2 grupos según el patrón esquelético (clase II y clase III). Se clasificaron los patrones esqueléticos midiendo el ángulo ANB de cada paciente. El diámetro antero-posterior del cóndilo mandibular derecho e izquierdo se evaluó desde una vista sagital al localizar los puntos A y P para obtener una distancia en mm. Por otro lado, el plano coronal permitió evaluar el diámetro medio-lateral donde se trazaron los puntos M y L para obtener de la misma manera una medida en mm. Resultados: Se encontraron diferencias significativas en los diámetros medio-laterales entre la clase III y clase II, siendo este mayor en aquellos pacientes clase III. Para la clase II el diámetro medio-lateral derecho presenta una media de 17.94 ±2.68 y el izquierdo de 17.67 ±2.44, mientras que para la clase III la media encontrada para el cóndilo derecho fue de 19.16 ±2.75 y del izquierdo 19.16±2.54. Conclusiones: Se encontró que el diámetro medio-lateral de los pacientes de patrón esquelético clase III es mayor que aquellos de clase II.
Objective: Evaluate condylar morphology in patients with skeletal pattern class II and class III. Materials and methods: CT scans of 124 patients (18 to 30 years) were evaluated. They were divided into 2 groups according to the skeletal pattern (class II and class III). Skeletal patterns were classified by measuring the ANB angle of each patient. The antero-posterior diameter of the right and left mandibular condyle was assessed from a sagittal view by locating points A and P to obtain a distance in mm. On the other hand, the coronal plane allowed to evaluate the medial-lateral diameter where the points M and L were drawn to obtain in the same way a measurement in mm. Results: Significant differences were found in the mid-lateral diameters between class III and class II.The measures were higher in those class III. For class II, the right mid-lateral diameter presents an average of 17.94 ± 2.68 and the left one of 17.67 ± 2.44, while for class III the average found for the right condyle was 19.16 ± 2.75 and the left one 19.16 ± 2.54. Conclusion: It was found that the medial-lateral diameter of patients with skeletal class III is higher than those of class II.
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29

Bernos, Callirgos Nicolas. "Conservando la "clase": reproducción y cambio social en dos trayectorias de clase media "tradicional"." La Colmena, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/91468.

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El presente artículo ofrece un avance parcial de los hallazgos de un proyecto de tesis en curso. Esta tesis propone una aproximación a la reproducción y el cambio social de un grupo de familias limeñas de clase media tradicional a lo largo de tres generaciones. A partir de la elaboración de historias de vida y familiares, la investigación busca desentrañar las estrategias de reproducción familiares históricamente situadas que hicieron posible el mantenimiento o la movilidad social y su transmisión de una generación a otra. En este artículo me he enfocado en narrar esquemáticamente las historias sociales de dos de las familias elegidas, tomando únicamente los testimonios de la generación mayor de ambas familias. El objetivo del artículo es exponer esquemáticamente algunos momentos de ruptura en sus trayectorias ocupacionales y su vinculación con ciertos procesos históricos y económicos, así como con los acontecimientos dentro de sus núcleos familiares y sus propios ciclos vitales. Adicionalmente, mediante la exploración de las estrategias de inversión en sus hijos (en su esfuerzo de transmitirles recursos materiales y simbólicos que les aseguren mejores condiciones y mayores oportunidades de vida), se analizarán las representaciones que los dos entrevistados tienen sobre las jerarquías sociales y el éxito en la sociedad. Lo presentado aquí representa una parte acotada de lo que vienen siendo los hallazgos del proyecto de investigación, que espera ver la luz dentro de poco.
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30

Keith, Karin. "These are the Days of Close Reading: Using Readers’ Theatre to Teach Close Reading." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/1017.

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31

Vanderwall, Donna Staab. "Continuity of sibling relationships: A descriptive profile of "close" vs. "not-close" sibling relationships." CSUSB ScholarWorks, 1989. https://scholarworks.lib.csusb.edu/etd-project/132.

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32

Alboudwarej, Hussein. "Analysis of close contact melting." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0010/MQ35012.pdf.

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33

Winzen, Stefan. "Close to regular multipartite tournaments." kostenfrei, 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974007501.

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34

Hornik, Kurt. "A CLUE for CLUster ensembles." Institut für Statistik und Mathematik, WU Vienna University of Economics and Business, 2005. http://epub.wu.ac.at/1690/1/document.pdf.

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Анотація:
Cluster ensembles are collections of individual solutions to a given clustering problem which are useful or necessary to consider in a wide range of applications. The R package clue provides an extensible computational environment for creating and analyzing cluster ensembles, with basic data structures for representing partitions and hierarchies, and facilities for computing on these, including methods for measuring proximity and obtaining consensus and "secondary" clusterings. (author's abstract)
Series: Research Report Series / Department of Statistics and Mathematics
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35

curso, Profesores del. "Clase 2: fisiología y conducta." Universidad Peruana de Ciencias Aplicadas - UPC, 2008. http://hdl.handle.net/10757/272436.

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36

Verand, Marcel. "Clase de Liderazgo y Gerencia." Universidad Peruana de Ciencias Aplicadas - UPC, 2009. http://hdl.handle.net/10757/272601.

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37

Dickson, Liam. "Topics regarding close operator algebras." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/6276/.

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In this thesis we focus on two topics. For the first we introduce a row version of Kadison and Kastler's metric on the set of C*-subalgebras of B(H). By showing C*-algebras have row length (in the sense of Pisier) of at most two we show that the row metric is equivalent to the original Kadison- Kastler metric. We then use this result to obtain universal constants for a recent perturbation result of Ino and Watatani, which states that succiently close intermediate subalgebras must occur as small unitary perturbations, by removing the dependence on the structure of inclusion. Roydor has recently proved that injective von Neumann algebras are Kadison-Kastler stable in a non-self adjoint sense, extending seminal results of Christensen. We prove a one-sided version, showing that an injective von Neumann algebra which is nearly contained in a weak*-closed non-self adjoint algebra can be embedded by a similarity close to the natural inclusion map. This theorem can then be used to extend results of Cameron et al. by demonstrating Kadison-Kastler stability of certain crossed products in the non self-adjoint setting. These crossed products can be chosen to be non-amenable.
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38

Roberts, Kristina. "Secluded and close to everything." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1334932984.

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39

Keenan, Brendan Owen. "Petals of a Rose Close." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406810012.

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40

Van, Tongeren Daryl R. "Meaning Maintenance in Close Relationships." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2391.

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The human motivation for meaning has been a longstanding topic of inquiry, and recent research has begun to investigate how individuals maintain a sense of meaning in life. Given the importance of social connectedness in human life, as well as the role of relationships in providing a sense of meaningfulness, the present investigation explored meaning maintenance within the domain of close relationships. Specifically, a theoretical model for interpersonal meaning maintenance is presented, which proposes that moral actions—particularly forgiveness—are oriented toward restoring relationship quality, and, in turn, meaning in life, in the wake of interpersonal transgressions. The tenets of this model were tested in two studies. Study 1 provided initial evidence for this model by examining dispositional characteristics that are important for one’s relationship (e.g., trait empathy, self-esteem) and provided promising results that support a more specific investigation within the domain of close relationships. Implementing a longitudinal study design, Study 2 examined interpersonal offenses committed by romantic partners over six months, as well as the degree of forgiveness offered by the hurt partner, and the subsequent effects on relationship quality and meaning in life. The results revealed that, as hypothesized, initial levels of meaning in life predicted committing fewer moral offenses against one’s partner and offering more forgiveness when suffering a transgression by one’s partner. Although transgressing against one’s partner did not reduce meaning in life, offering forgiveness increased meaning in life and life satisfaction over time. In addition, relationship satisfaction partially mediated the effects of forgiveness on meaning in life, and self-esteem was found to moderate this mediating relationship. Support for the model of interpersonal meaning maintenance was garnered in two studies. The present investigation was the first to explore how individuals maintain meaning within the domain of close relationships. Implications for the scientific study of meaning, as well as for applications in relationships, are discussed.
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41

Parker, Brandon S. "CLUE: A Cluster Evaluation Tool." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5444/.

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Modern high performance computing is dependent on parallel processing systems. Most current benchmarks reveal only the high level computational throughput metrics, which may be sufficient for single processor systems, but can lead to a misrepresentation of true system capability for parallel systems. A new benchmark is therefore proposed. CLUE (Cluster Evaluator) uses a cellular automata algorithm to evaluate the scalability of parallel processing machines. The benchmark also uses algorithmic variations to evaluate individual system components' impact on the overall serial fraction and efficiency. CLUE is not a replacement for other performance-centric benchmarks, but rather shows the scalability of a system and provides metrics to reveal where one can improve overall performance. CLUE is a new benchmark which demonstrates a better comparison among different parallel systems than existing benchmarks and can diagnose where a particular parallel system can be optimized.
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42

Sharp, L. Kathryn. "Close Reads and Guided Reading." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/4286.

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43

Tolley-Stokes, Rebecca. "Close the Online Class Divide." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/5763.

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44

Shieh, Hester F. "The CLASE Study: Endovascular Management of the Superficial Femoral Artery." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/221411.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
Objectives – The purpose of this study was to compare endovascular treatment modalities for peripheral vascular disease in the femoropopliteal arteries with respect to technical success, efficacy, and patency at mid-term follow up. Methods – A retrospective review of patients that underwent endovascular management of the femoropopliteal segment was conducted to evaluate patency. The CLASE study included five treatment arms: cryoplasty, laser, angioplasty/stent, Silverhawk atherectomy, and Viabahn endoluminal graft. Results – Between November 2004 and May 2009, 306 patients met inclusion criteria. There was a statistically significant difference in patencies among treatment groups (p=0.016), driven by laser having a significantly lower patency than the angioplasty/stent, Silverhawk atherectomy, and Viabahn endoluminal graft groups. Conclusions – Many of the expensive endovascular devices have poor patencies lasting less than six months. Angioplasty/stent is not inferior to these new devices, and may remain the standard of care.
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45

Viale, Tudela Héctor. "Organización de la clase:¿preparo mi clase para enseñar o para que el alumno aprenda?" Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/325520.

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Анотація:
Cuando preparamos y organizamos nuestra clase, no debemos pensar únicamente en qué vamos a decir o cómo lo diremos. Su organización debe trascender la preocupación del dictado. Debemos incorporar tareas para que el estudiante tenga una actitud activa durante la clase: no debemos limitarnos a desarrollar sus habilidades intelectuales, que corresponden a la situación pasiva de escuchar al profesor. Debemos procurar que el estudiante involucre, en su proceso de aprendizaje, otras habilidades que incentiven su aspecto cognitivo: con ello, el docente adquiere un rol de mediador, entregándole protagonismo al estudiante. Debemos buscar un equilibrio entre el profesor, el alumno y las tareas o actividades diseñadas. En este artículo, reflexionaremos sobre las ventajas de tener un buen diseño de clase, en el cual ya no se busque enseñar solo contenidos, sino enseñar a aprender; ya no será la asignatura, sino el alumno, el centro del sistema de enseñanza-aprendizaje; ya no será una formación solo basada en conocimientos, sino una formación integral que abarque diversas competencias transversales.
hviale@upc.edu.pe
When we prepare and organize a class, we must not only think about what we say or how to say it. Class organization must transcend the concerns of the dictation. We must incorporate tasks so the students can have an active attitude in class: we must not only develop their intellectual abilities, which correspond to the passive situation of listening to the teacher. We must ensure that in the learning process the student involves other skills that stimulate their cognitive aspect: with this in mind, the teacher takes on a mediating role, giving prominence to the student. We must seek a balance between teacher, student and the tasks or activities designed. In this article, we will reflect on the advantages of having a good class design, which no longer look only at the content that is taught, but it concentrates on teaching how to learn; it no longer the course but
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46

Botelho, Fernanda Alves. "Desenvolvimento e validação de metodologia analítica para a determinação de tuberculostáticos de dose fixa combinada (FDC) e suas substâncias relacionadas." reponame:Repositório Institucional da FIOCRUZ, 2013. https://www.arca.fiocruz.br/handle/icict/13447.

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Анотація:
Made available in DSpace on 2016-04-04T12:26:00Z (GMT). No. of bitstreams: 2 2.pdf: 3729000 bytes, checksum: 78661b59dc7c742033ca6ce5a153cc47 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2013
Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil.
O crescimento do número de casos de tuberculose no Brasil fez com que o Governo Federal desenvolvesse uma política nacional de controle da tuberculose que possibilitasse melhorar e prolongar a qualidade de vida dos indivíduos infectados. Esta política inclui, entre várias outras iniciativas, o aumento na adesão de pacientes com um tratamento terapêutico adequado utilizando Formulações de Doses Fixas Combinadas (FDC), contendo os fármacos aos quais o bacilo de Koch é mais sensível. Um dos pontos críticos para o desenvolvimento de tuberculostáticos é o desenvolvimento de metodologias analíticas para seu controle que sejam viáveis, eficazes e robustas, uma vez que a rifampicina um dos insumos farmacêuticos ativos (IFAs) da associação apresenta características peculiares como a sua baixa estabilidade em solução, o que pode levar à formação de muitos produtos de degradação. O presente estudo tem por objetivo otimizar e validar uma metodologia analítica que seja adequada à rotina de um laboratório de controle de qualidade para a determinação dos fármacos isoniazida e rifampicina (ambos IFAs da formulação) e suas substâncias relacionadas, associados em comprimidos de dose fixa combinada para serem utilizados no tratamento dos casos da tuberculose e serem distribuídos pelo Sistema Único de Saúde. Para tanto, foi otimizada e validada uma metodologia analítica utilizando a técnica de cromatografia líquida de alta eficiência (CLAE) capaz de determinar não só o teor dos insumos farmacêuticos ativos (IFAs) presentes na formulação, mas também de quantificar as suas substâncias relacionadas. Um estudo de estabilidade de longa e acelerada durações também foi conduzido e a metodologia analítica otimizada e validada foi usada para avaliação dos comprimidos, mostrando sua capacidade de detectar o esperado decaimento do teor dos IFAs e o aumento no teor de suas substâncias relacionadas. Posteriormente, houve a transferência do método para a técnica de cromatografia líquida de ultraeficiência (CLUE), visando uma análise cromatográfica em tempo mais curto e uma maior sensibilidade do método. Essa metodologia utilizando a técnica de CLUE também foi validada.
As the number of tuberculosis (TB) cases in Brazil is rising, the brazilian Government implemented a national policy for TB control that would enable to improve and endure the quality of life in infected individuals. This policy includes, among many actions, the increase of the patient’s adhesion by a therapeutic treatment using suitable formulations of Fixed Dose Combination (FDC) including drugs to which M. tuberculosis is more sensitive. One critical point for FDC formulation development is the establishment of viable, effective and robust analytical methods for its quality control, since rifampicin – one of the formulation’s active pharmaceutical ingredient (API) – has particular characteristics such as its low stability in aqueous solution, which can lead to formation of many degradation products. This study aims to optimize and validate an analytical methodology for the determination of isoniazid and rifampicin (both APIs in the formulation) and their related substances en tablets with fixed dose. This medicines will be distributed by the national health system for the treatment of tuberculosis patients. Therefore, an analytical method was optimized and validated using the technique of high performance liquid chromatography (HPLC) that can evaluate not only the dosage of APIs in the formulation, but also to determine their related substances. A stability study of accelerated and long durations was also conducted and the optimized analytical method was used to evaluate the tablet, showing its ability to detect the expected reduction of API dosage and the increase in the amount of its related products. Later, an upgrade of the optimized and validated method to ultra-high performance liquid chromatography (UPLC) was succefully performed, with the reduced chromatographic analysis time and increased sensitivity. This UPLC methodology has also been validated.
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47

Nellsjö, Jonas. "Close Air Support i moderna operationer." Thesis, Försvarshögskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-1438.

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De svenska insatsförbanden anpassas för de konflikter som är normgivande idag. Konceptuellt innebärdetta att doktriner och metoder måste utvecklas för att möta utvecklingen på dagens stridsfält. Denkonceptuella utvecklingen är förhållandevis billig jämfört med den tekniska, vilket innebär attförmågeutvecklingen mer anpassas till de materiella förutsättningarna som råder. Plattformar för CloseAir Support symboliserades under 80- och 90-talet av tungt beväpnade och särskilt anpassade flygplanoch helikoptrar som verkade i nära anslutning till markförbandens strid. Idag representeras dessaplattformar av andra flygsystem som sedan tidigare är utvecklade utifrån andra kravprofiler. Dennaobservation ligger till grund för undersökningen och formulerar därmed uppsatsens problem.Har innebörden av konceptet Close Air Support på senare tid förändrats och på så vis öppnat förandra typer av flygsystem att utöva detta koncept?Uppsatsens syfte är att undersöka hur Close Air Support tillämpats under tre moderna operationer föratt därmed finna orsaker till hur konceptet utvecklats till vad det representerar idag. Dessutom syftaruppsatsen till att klarlägga begreppets innebörd och därmed bidra med kunskap inom konceptet förClose Air Support.Undersökningen analyserar Close Air Support historiska ursprung och teorierna bakom kombineradevapen. Denna analys lägger grunden till den fallstudie som omfattar tre militära operationergenomförda efter 1990. Studien fokuseras mot samordning, plattformar och operativ och taktisk effekt.Avslutande diskussion påvisar att samordning av Close Air Support tillämpats olika under de studeradeoperationerna. De förutsättningar som råder för dagens konflikter möjliggör att användningsområdenför olika vapensystem kan utökas. Detta är en av förklaringarna till varför andra typer avstridsflygsystem idag utnyttjas för Close Air Support. Studien har visat att CAS som koncept inteförändrats. Däremot har Close Air Support tillämpats olika beroende på de operativa förutsättningarnasom rådde inför respektive operationUppsatsen föreslår tre områden inom ämnet som kan vara föremål för djupare analys.
The Swedish Armed Forces are transforming to be able to conduct military operations in today’sstandard conflicts. To meet the demands that the new type of conflict represents the transformationrequires a development of new doctrines and tactical manuals. .Developments of new weapon systems are proportionately much more expensive than conceptualdevelopments. The armed forces’ combat capability must be adapted to existing military technologicalconditions. During the 1980s and 1990s Close Air Support aircrafts were represented by heavily armedand armoured fixed- and rotary-wing aircrafts which carried out CAS missions in close proximity tofriendly forces. These CAS platforms are today, more or less, represented by traditional fighter andstriker aircrafts. This observation will form the basis of this research and thereby formulate thescientific question.Has the significance of Close Air Support been changed and is it therefore made it possible to useother combat aircrafts for Close Air Support missions?The purpose of this thesis is to examine how Close Air Support has been put in practise in threemodern operations and to ascertain how this has developed the concept to what it is today.Furthermore the thesis will also clarify the significance of the concept and thereby contribute withknowledge to the concept of Close Air Support.The research will analyze the concept’s historical origin and the theory behind combined arms. Thisanalysis will form the basis for the following case studies, which comprise three military operationscarried out after 1990. The research will focus on coordination, platforms and operational and tacticaleffects.The final discussion will show that coordination of CAS has been executed differently during the threestudied operations. Today’s conflicts make it possible to use weapon systems in an extended role. Thiswill explain why different combat aircraft could be used in a CAS role. The research shows that theCAS concept hasn’t changed. However, CAS has been performed in different ways depending on theoperational circumstances within each operation.The thesis suggests three new research areas within the subject that could be appropriate for furtherexaminations.
Avdelning: ALB - Slutet Mag 3 C-upps. Hylla: Upps. ChP 06-08
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48

Ooi, Jinnie. "Anxiety-related cognitions in close relationships." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/59248/.

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Анотація:
Etiological models of anxiety have increasingly emphasized the role of information processing biases, and there is evidence that children, as well as adults exhibit these biases. However, to date, little is known about the origins of these biases. This thesis aims to explore whether interpretation bias and fear beliefs might be acquired from significant others in close relationships (i.e., parents, friends and romantic partners). It also considers a range of developmental stages to identify potential sources of influence that may play a role in the acquisition and/or maintenance of information processing biases across development. The thesis aims are realised across four studies that explore shared anxiety-related cognitions in distinct close relationships. The main findings of this thesis are summarized as follows. First, there is some evidence that individuals in close relationships exhibit similar patterns of anxiety-related cognitions, namely in close friends in middle childhood, as well as in parents and their young adult children. Second, there is some indication that anxietyrelated cognitions might be acquired via the verbal information pathway from significant others in close relationships, such as from parents, close friends, and romantic partners. Third, factors such as the difference in anxiety levels between individuals in close relationships, relationship closeness, and attachment do not appear to moderate the transmission of anxiety-related cognitions in close relationships. Finally, results showed a significant relationship between anxiety-related cognitions and anxiety in middle childhood and young adulthood, but not in early childhood, indicating that interpretation bias may initially develop during the preschool years and may not show an association with anxiety until middle childhood. Taken together, these results indicate that anxiety-related cognitions can be transmitted within close relationships, and that verbal information appears to be a viable pathway in which such cognitions may be transmitted.
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Luong, Trân-Quân 1979. "Layered imagery in Chuck Close portraiture." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84057.

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This thesis explores layered imagery in the portraiture of Chuck Close. Portraits that exhibit qualities of layered imagery appear as an integrated whole from a distance, but as the observer approaches the canvas, the figure of the portrait disintegrates into atomic elements that stand on their own. We present a discussion of the perceptual principles that permit the effects of layered imagery, and apply these principles to the creation of systems that emulate Close's blobby and fingerprint styles. We discuss the textural aspects of his portraits that contribute to the effect of layered imagery, and detail methods to reproduce these effects. Finally, we present novel stylised renderings inspired by Close's artwork.
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50

curso, Profesores del. "Percepción de uno mismo: clase 4." Universidad Peruana de Ciencias Aplicadas - UPC, 2008. http://hdl.handle.net/10757/272435.

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