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Статті в журналах з теми "CJRj"
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Šmajs, David, and George M. Weinstock. "The Iron- and Temperature-RegulatedcjrBC Genes of Shigella and Enteroinvasive Escherichia coli Strains Code for Colicin Js Uptake." Journal of Bacteriology 183, no. 13 (July 1, 2001): 3958–66. http://dx.doi.org/10.1128/jb.183.13.3958-3966.2001.
Повний текст джерелаАнотація:
ABSTRACT A cosmid library of DNA from colicin Js-sensitive enteroinvasiveEscherichia coli (EIEC) strain O164 was made in colicin Js-resistant strain E. coli VCS257, and colicin Js-sensitive clones were identified. Sensitivity to colicin Js was associated with the carriage of a three-gene operon upstream of and partially overlapping senB. The open reading frames were designated cjrABC (for colicin Js receptor), coding for proteins of 291, 258, and 753 amino acids, respectively. Tn7 insertions in any of them led to complete resistance to colicin Js. A near-consensus Fur box was found upstream ofcjrA, suggesting regulation of the cjroperon by iron levels. CjrA protein was homologous to iron-regulatedPseudomonas aeruginosa protein PhuW, whose function is unknown; CjrB was homologous to the TonB protein fromPseudomonas putida; and CjrC was homologous to a putative outer membrane siderophore receptor from Campylobacter jejuni. Cloning experiments showed that the cjrBand cjrC genes are sufficient for colicin Js sensitivity. Uptake of colicin Js into sensitive bacteria was dependent on the ExbB protein but not on the E. coli K-12 TonB and TolA, -B, and -Q proteins. Sensitivity to colicin Js is positively regulated by temperature via the VirB protein and negatively controlled by the iron source through the Fur protein. Among EIEC strains, two types of colicin Js-sensitive phenotypes were identified that differed in sensitivity to colicin Js by 1 order of magnitude. The difference in sensitivity to colicin Js is not due to differences between the sequences of the CjrB and CjrC proteins.
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Barbier, E., J. Carpentier, O. Simonin, A. Chaumy, W. Laine, S. Anthérieu, P. Marchetti, J. M. Lo Guidice, J. Kluza, and G. Garçon. "OS01-09 Mitochondrial dysfunction trigerred by air pollution-derived ultrafine particles chronic exposure in the lungs of Balb/cJRj mice." Toxicology Letters 384 (September 2023): S61—S62. http://dx.doi.org/10.1016/s0378-4274(23)00419-8.
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Min, Arim, Bo-eun Kwon, Hyunjeong Kim, Hyunkyung Park, Jiyoung Lee, Kyoung-Ho Pyo, and Byoung Chul Cho. "Abstract 3527: Novel bacteria strains, CJRS-10671 and CJRS-10672, enhance anti-tumor efficacy in LLC1 syngeneic model and humanized PDX mice model." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3527. http://dx.doi.org/10.1158/1538-7445.am2022-3527.
Повний текст джерелаАнотація:
Abstract Background: Immune checkpoint inhibitor has emerged as remarkable therapeutic that improves the anti-cancer effect of patients. However, response rate is low in a large proportion of patients. The overall efficacy of immune checkpoint inhibitor therapy remains unsatisfactory. Recently, live biotherapeutic products (LBPs) have emerged as potential therapeutics to overcome the limitation of immune checkpoint inhibitor. Here, we demonstrated the efficacy of CJRS-10671 and CJRS-10672 in tumor bearing mice models. Methods: To evaluate anti-tumor effects, 109 CFU/mouse CJRS-10671 was administered via oral gavage twice daily (BID) alone or in combination with anti-PD-1 (10 mg/kg, QOD, i.p.) for 10 days in a Lewis Lung Carcinoma (LLC1) syngeneic tumor model. Tumor growth was measured by calipers 3 times per week. We analyzed immune cell profiles by flow cytometry. In lung squamous cell carcinoma patient derived xenograft (PDX) model,109 CFU/mouse CJRS-10671 and CJRS-10672 were orally administered twice daily (BID) alone or in combination with pembrolizumab (10 mg/kg, Q5D, i.p.) for 35 days. Tumor growth was measured by calipers 3 times per week. We analyzed immune cell profiles and single cell RNA sequencing. Results: In LLC1 syngeneic tumor model, CJRS-10671 alone suppressed tumor growth comparable to that of immune checkpoint inhibitor (anti-PD-1 antibody) only treatment group. Combined administration of CJRS-10671 and immune checkpoint inhibitor significantly suppressed tumor growth (p<0.05). We found that combination of CJRS-10671 with anti-PD-1 antibody increased the population of CD8+IFN-γ+ cells in splenocytes and tumor-infiltrating lymphocytes (TILs).In humanized PDX model, CJRS-10671 alone significantly suppressed tumor growth compared with that of vehicle control and pembrolizumab only treatment (p<0.001). CJRS-10672 alone suppressed tumor growth compared with that of vehicle control (p<0.001) which is comparable with the efficacy of pembrolizumab alone. Combined administration of CJRS-10672 and pembrolizumab further significantly suppressed tumor growth than pembrolizumab alone (p<0.01). None of the mice in pembrolizumab showed more than 75% tumor growth inhibition cut-off (TGI-75%). Fifty percent of the mice in CJRS-10671 single treated group showed over TGI-75%. The groups of pembrolizumab combination with CJRS-10672, pembrolizumab combination with CJRS-10671, CJRS-10672 alone were observed 25%, 20%, and 11.1%, respectively (>TGI-75%).We confirmed that administration of CJRS-10671 increased population of CD8+ central memory T cells in tumor. Also, TGI (%) directly related features were mostly antigen presentation and monocyte origin cells, especially macrophage in immune-profiling analysis. Furthermore, we observed that CJRS-10671 and CJRS-10672 were associated with signaling of damage-associated molecular pattern (DAMP) and especially CJRS-10671 was related to nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling by single cell RNA sequencing analysis. Conclusion: CJRS-10671 and CJRS-10672, single administration or combination with anti-PD-1 antibody, have potential anti-tumor effect. Citation Format: Arim Min, Bo-eun Kwon, Hyunjeong Kim, Hyunkyung Park, Jiyoung Lee, Kyoung-Ho Pyo, Byoung Chul Cho. Novel bacteria strains, CJRS-10671 and CJRS-10672, enhance anti-tumor efficacy in LLC1 syngeneic model and humanized PDX mice model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3527.
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Zhu, Zhende, Xiangcheng Que, Zihao Niu, and Wenbin Lu. "Model Test Study on the Anisotropic Characteristics of Columnar Jointed Rock Mass." Symmetry 12, no. 9 (September 16, 2020): 1528. http://dx.doi.org/10.3390/sym12091528.
Повний текст джерелаАнотація:
Because of its special structure, the anisotropic properties of columnar jointed rock mass (CJRM) are complicated, which brings difficulty to engineering construction. To comprehensively study the anisotropic characteristics of CJRM, uniaxial compression tests were conducted on artificial CJRM specimens. Quadrangular, pentagonal and hexagonal prism CJRM models were introduced, and the dip direction of the columnar joints was considered. Based on the test results and the structural features of the three CJRM models, the deformation and strength characteristics of CJRM specimens were analyzed and compared. The failure modes and mechanisms of artificial specimens with different dip directions were summarized in accordance with the failure processes and final appearances. Subsequently, the anisotropic degrees of the three CJRM models in the horizontal plane were classified, and their anisotropic characteristics were described. Finally, a simple empirical expression was adopted to estimate the strength and deformation of the CJRM, and the derived equations were used in the Baihetan Hydropower Station project. The calculated values are in good agreement with the existing research results, which reflects the engineering application value of the derived empirical equations.
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Chao, Zhiming, Guotao Ma, Xiewen Hu, and Yuzhe Zhu. "Investigation of Anisotropic Permeability and Porosity of CJRM considering Different Confinement Loading Pressures." Advances in Civil Engineering 2020 (July 3, 2020): 1–12. http://dx.doi.org/10.1155/2020/4609578.
Повний текст джерелаАнотація:
An innovative method is proposed to prepare artificial columnar jointed rock masses (CJRM) with different columnar dip angles, and laboratory physical model tests are conducted to investigate anisotropic permeability and porosity characteristics of the prepared artificial CJRM. In the physical model experiment, permeability and porosity of artificial CJRM with different columnar dip angles is measured during three times cyclic loading and unloading of confinement pressure. Based on the results of the laboratory model tests, the Equivalent Continuum Media Model was applied to analyse anisotropic permeability of CJRM. The main conclusions are summarized as follows. In the first loading phase of confinement pressure, the impacts of confinement pressure on the anisotropic permeability of artificial CJRM, porosity, and the major and minor principle permeability coefficients (PPCs) are significant, while in the following stages of confinement pressure loading and unloading, the change of them is small, with stable value. Permeability of artificial CJRM gradually increases with rise of columnar dip angle, and the permeability anisotropy of artificial CJRM under low confinement pressure is higher than that under low confinement pressure.
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Min, Arim, Chun-bong Synn, Seong-san Kang, Bo-eun Kwon, Junwon Yang, Hyunkyung Park, Jieun Im, et al. "Abstract 6433: A novel bacterial strain, CJRB-101, induces anti-cancer effects by repolarization of M2 to CXCL9 and CXCL10 dual expressing M1 macrophages in humanized non-small cell lung cancer mice models." Cancer Research 83, no. 7_Supplement (April 4, 2023): 6433. http://dx.doi.org/10.1158/1538-7445.am2023-6433.
Повний текст джерелаАнотація:
Abstract Backgrounds: Live biotherapeutic products (LBPs) emerged as potential therapeutics to overcome the limitation of ICIs. This research shows that CJRB-101, a novel bacterial strain, can improve anti-tumor effects in synergy with pembrolizumab in non-small cell lung cancer (NSCLC). Objectives and Methods: Tumors from NSCLC patients (anti-PD-1 refractory and resistant) were transplanted into Hu-CD34-NSG to establish humanized patient-derived xenograft (PDX) mice models. Five models (YHIM-2003, 2004, 2009, 2010 and 2014) were treated with CJRB-101 at low (5 × 107 CFU) or high (109 CFU) doses, or with pembrolizumab (10 mg/kg, i.p., Q5D) or in combination. Tumor growth inhibition (TGI) rate was measured. Tumor microenvironment (TME) was analyzed using multiplex IHC, flow cytometry and single cell RNA sequencing. Ex-vivo assays were performed to validate in silico findings. Results: Tumor in PDX models was unresponsive to pembrolizumab alone, however, in combination with CJRB-101 effectively suppressed tumor growth. The synergy was highlighted in YHIM-2009 where TGI was 10-fold higher (56%) than pembrolizumab group (5%). Immune profiling revealed that macrophages may be responsible for the anti-tumor effects of CJRB-101. IHC showed significantly increased antigen presenting specialized DCs (CD16+CD68−CD11c+) and granzyme B+ CD8+ T cells in the tumor by CJRB-101 compared to pembrolizumab (p<0.01). This suggested that CJRB-101 induced infiltration of cytotoxic CD8 T cells into the tumor nest by enhancing antigen presenting machinery. Trajectory analysis showed that CJRB-101 induced repolarization of M2 to M1 macrophages, characterized by high expression of CXCL9/10. CXCL9+/10+ M1 macrophages were comparatively more abundant in the combination group (23.11%) than the pembrolizumab group (0.91%). CXCL9/CXCL10 expression in macrophages was higher in the CJRB-101 group compared to the pembrolizumab group (p<0.0001). The combination group (10.84%) had a higher relative abundance of CD8+ T cells compared to the pembrolizumab group (1.58%) and higher IFNγ expression in CD8+ T cells compared to the pembrolizumab group (p=0.0152), suggesting that CJRB-101 repolarized macrophages and recruited active CD8+ T cells. Co-culture assays using bone marrow-derived macrophages validated that CJRB-101 drove differentiation towards F4/80+ or MHC II+ expressing M1 macrophage (p<0.0001) and repolarized existing M2 (CD206+) to M1 (p=0.0002). Conclusion: Combination treatment of CJRB-101 with anti-PD-1 showed synergistic anti-tumor effects via repolarization of M2 to M1 macrophages, leading to activation of CD8+ T cells in TME. Especially, CXCL9+/10+ M1 macrophage playing a key role in TGI induced by CJRB-101 in NSCLC models. Findings from this study provided rationale for clinical investigation of CJRB-101. Citation Format: Arim Min, Chun-bong Synn, Seong-san Kang, Bo-eun Kwon, Junwon Yang, Hyunkyung Park, Jieun Im, Hyunjeong Kim, Sujeong Beak, Dong Kwon Kim, Jii Bum Lee, Hyeonseok Oh, Seung Min Yang, Yu Jin Han, Mi hyun Kim, Heekyung Han, Kwangmin Na, Young Taek Kim, Sungwoo Lee, Mi Ran Yun, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Ji Yun Lee, Chang Gon Kim, Min Hee Hong, Sun Min Lim, Kyoung-Ho Pyo, Byoung Chul Cho. A novel bacterial strain, CJRB-101, induces anti-cancer effects by repolarization of M2 to CXCL9 and CXCL10 dual expressing M1 macrophages in humanized non-small cell lung cancer mice models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6433.
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Kim, Jung-Hwan, Heejung Yang, and Kee K. Kim. "Camellia japonica Root Extract Increases Antioxidant Genes by Induction of NRF2 in HeLa Cells." Plants 11, no. 21 (October 29, 2022): 2914. http://dx.doi.org/10.3390/plants11212914.
Повний текст джерелаАнотація:
Camellia japonica L. (Theaceae) has been used for medicinal and cosmetic purposes in East Asian countries. Most functional components were obtained from the upper parts of the tree, such as leaves, flowers, or seeds. Here, we report a functional effect of the 80% methanolic extract of C. japonica root (CJRE) on antioxidative stress in HeLa cells. The nuclear factor erythroid-derived 2-related factor 2 (NRF2) is a key transcription factor that triggers the induction of oxidative stress-relating genes and drug detoxification. As result, CJRE showed a strong anti-radical scavenging effect in a dose-dependent manner. In addition, the induction of antioxidant response elements (ARE)-luciferase activity was maximized at CJRE 200 µg/mL. Furthermore, CJRE induced the mRNA levels of HO-1 and NQO1 by the nuclear NRF2 accumulation. As a possible mechanism of Nrf2 activation, the phosphorylation of p38 and ERK1/2 signaling might fortify the NRF2 induction as well as its stability. However, the phosphorylation of AKT is rather decreased. Taken together, CJRE may potentiate the antioxidant effects by increasing the NRF2 signaling through MAP kinase signaling and the properties of its radical scavenging activity. Thus, CJRE could apply for other medicinal and cosmetic purposes.
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Xu, Jianrong, Hao Li, Qingxiang Meng, Weiya Xu, Mingjie He, and Jiahui Yang. "A Study on Triaxial Unloading Test of Columnar-Jointed-Rock-Mass-Like Material with AW Velocity Analysis." Advances in Civil Engineering 2020 (December 24, 2020): 1–14. http://dx.doi.org/10.1155/2020/6693544.
Повний текст джерелаАнотація:
To study the strength, deformation, and failure patterns of columnar-jointed-rock-mass (CJRM) under unloading conditions, triaxial unloading tests using the CJRM-like material samples are carried out, and acoustic wave (AW) velocities are simultaneously recorded. Based on stress-strain curves and AW velocities under different initial confining pressures and unloading rates, the stress-strain characteristics, strength, and deformation parameters, failure modes, and variation of the AW velocity are analyzed. Test results show that the CJRM may exhibit intense volume expansion during the unloading process. With the increase of the unloading and its rate, the volume expansion becomes more serious and the failure mode becomes more complicated. By reducing the unloading (rate), a phenomenon of unloading relaxation is observed and the quality of CJRM is significantly improved. The AW velocity of CJRM shows a strong correlation with the volume strain, which verifies the effectiveness of applying AW velocity for assessing the rock quality. It is hoped that the research results may provide a reference for the construction and operation of the Baihetan Hydropower Project.
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Niu, Zihao, Zhende Zhu, and Xiangcheng Que. "Constitutive Model of Stress-Dependent Seepage in Columnar Jointed Rock Mass." Symmetry 12, no. 1 (January 13, 2020): 160. http://dx.doi.org/10.3390/sym12010160.
Повний текст джерелаАнотація:
Columnar jointed rock mass (CJRM) is a highly symmetrical natural fractured structure. As the rock mass of the dam foundation of the Baihetan Hydropower Station, the study of its permeability anisotropy is of great significance to engineering safety. Based on the theory of composite mechanics and Goodman’s joint superposition principle, the constitutive model of joints of CJRM is derived according to the Quadrangular prism, the Pentagonal prism and the Hexagonal prism model; combined with Singh’s research results on intermittent joint stress concentration, considering column deflection angles, the joint constitutive model of CJRM in three-dimensional space is established. For the CJRM in the Baihetan dam site area, the Quadrangular prism, the Pentagonal prism and the Hexagonal prism constitutive models were used to calculate the permeability coefficients of CJRM under different deflection angles. The permeability anisotropy characteristics of the three models were compared and verified by numerical simulation results. The results show that the calculation results of the Pentagonal prism model are in good agreement with the numerical simulation results. The variation of permeability coefficient under different confining pressures is compared, and the relationship between permeability coefficient and confining pressure is obtained, which accords with the negative exponential function and conforms to the general rule of joint seepage.
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Wang, Luxiang, Zhende Zhu, Shu Zhu, and Junyu Wu. "A Case Study on Tunnel Excavation Stability of Columnar Jointed Rock Masses with Different Dip Angles in the Baihetan Diversion Tunnel." Symmetry 15, no. 6 (June 9, 2023): 1232. http://dx.doi.org/10.3390/sym15061232.
Повний текст джерелаАнотація:
Columnar jointed rock mass (CJRM) formed by intact rock divided by special symmetrical columnar joints is a special type of rock with poor mechanical properties, strong anisotropy, and weak self-supporting ability, severely affecting the excavation safety and stability of underground tunnels. In this study, taking the Baihetan hydropower station as the engineering background, CJRM geological numerical models with different dip angles that combined well with the natural CJRM were generated based on the geological statistical parameters of the engineering site and were verified to have high rationality and accuracy. Tunnel excavation and overloading tests were carried out on these numerical models, and the results showed that the stress and displacement distributions after excavation exhibited strong anisotropic characteristics under different dip angles, and the positions where engineering safety problems are most likely to occur are the side walls, which are prone to stress-structure-controlled failure mode. The self-supporting ability at different dip angles after excavation from weak to strong are 45°, 60°, 75°, 90°, 30°, 0°, and 15°. The safety factors assessed by overloading for CJRM with dip angles of 0–90° degrees were 2.5, 2.6, 2.6, 1.8, 2.1, and 2.2, respectively, providing a valuable reference for the construction safety and support measures of CJRM excavation.
Дисертації з теми "CJRj"
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Barbier, Emeline. "Étude des mécanismes physiopathologiques impliqués dans la toxicité des particules ultrafines chez un modèle murin : une approche multi-organes." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS063.
Повний текст джерелаАнотація:
Bien qu'une diminution conséquente de la pollution atmosphérique soit constatée depuis les années 1990, cette dernière demeure un problème de santé publique majeur, à l'origine de plus de 4,2 millions de décès prématurés par an dans le monde. À l'heure actuelle, l'attention des experts se concentre sur les particules ultrafines (PM0,1 ou PUF) en raison de leur capacité à transloquer dans la circulation systémique pour atteindre les organes périphériques où elles seront alors susceptibles d'avoir un impact néfaste. Néanmoins, les connaissances en termes de mécanismes cellulaires et moléculaires impliqués dans la toxicité de ces particules restent encore très parcellaires et demeurent, le plus souvent, centrées sur leur cible principale qu'est le poumon. Ainsi, ce projet de thèse avait pour objectifs principaux d'apporter des éléments novateurs sur la toxicocinétique (i.e., distribution/persistance) et la toxicodynamique (i.e., mécanismes physiopathologiques, voies de signalisation associées) de PUF prélevées en milieu urbain, d'une part, et les effets organo-spécifiques des PUF et l'utilisation des miARN circulants comme indicateurs d'exposition chronique et/ou cumulées aux PUF dans un modèle murin, d'autre part. Afin de répondre à ces interrogations, des souris Balb/cJRj ont été exposées durant 3 mois à différentes doses de PUF prélevées dans la zone urbaine de Lille, puis des analyses ont été réalisés au sein de différents organes-cibles richement vascularisés, et par conséquent directement exposés aux PUF lors de leur phase de translocation et de distribution systémique. Les résultats obtenus ont démontré que, dans l'ensemble des organes cibles, le potentiel oxydant intrinsèque des PUF induisait indéniablement la production d'espèces pro-oxydantes et l'activation de défenses antioxydantes en quantité suffisante pour rétablir un état d'homéostasie redox mais ne parvenant pas, cependant, à éviter l'apparition d'une réponse inflammatoire au niveau pulmonaire, cardiaque et cérébral. Des approches transcriptomiques réalisés au sein des poumons, organes cibles présentant les effets délétères les plus marqués, ont suggéré la dérégulation de nombreuses voies de signalisation en relation avec les réponses oxydante et inflammatoire, qui constituent les mécanismes centraux de toxicité des PUF mais aussi avec des mécanismes de toxicité plus originaux tels que la dysfonction mitochondriale, la transition épithélio-mésenchymateuse et le remodelage tissulaire, dont la modulation a également été validée d'un point de vue fonctionnel. Ces données prometteuses pourraient à terme contribuer à une meilleure prise de décision quant à la réduction des émissions des PUF de même qu'à la réactualisation des normes réglementaires actuellement en vigueurAlthough there has been a significant reduction in air pollution since the 1990s, it remains a major public health problem, responsible for over 4.2 million premature deaths worldwide every year. At present, experts' attention is focused on ultrafine particles (PM0.1 or UFP) because of their ability to translocate into the systemic circulation and reach peripheral organs, where they are likely to have a harmful impact. Nevertheless, the knowledge of the cellular and molecular mechanisms involved in the toxicity of these particles is still very patchy, and most often remains focused on their main target, the lung. Thus, the main objectives of this thesis project were to provide innovative insights into the toxicokinetics (i.e., distribution/persistence) and toxicodynamics (i.e., pathophysiological mechanisms, associated cell signaling pathways) of UFP collected in urban environments, on the one hand, and the organospecific effects of UFP and the use of circulating miRNA as indicators of chronic and/or cumulative exposure to UFP in a mouse model, on the other hand. To answer these questions, Balb/cJRj mice were exposed for 3 months to various doses of UFP collected in the urban area of Lille, then analyzed in various target organs richly vascularized, and therefore directly exposed to UFP during their translocation and systemic distribution phase. The results showed that, in all target organs, the intrinsic oxidative potential of UFP undeniably induced the production of oxidative oxygen species and the activation of antioxidant defenses in sufficient quantities to restore a state of redox homeostasis, but were unable to prevent the onset of an inflammatory response in the lungs, heart and brain. Transcriptomic approaches carried out in the lungs, the target organ with the most marked deleterious effects, have suggested the deregulation of numerous signaling pathways in relation to oxidative and inflammatory responses, which constitute the central mechanisms of UFP toxicity, but also with more original toxicity mechanisms such as mitochondrial dysfunction, epithelial-mesenchymal transition and tissue remodeling, whose modulation has also been validated from a functional point of view. These promising data could ultimately contribute to better decision-making on the reduction of UFP emissions, as well as to the updating of current regulatory standards
Книги з теми "CJRj"
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Best of CJR: 2012-2014. Claremont, CA: Kyle Jones, 2014.
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Custom CJJ 2002 - Juvenile Delinquency @ SCF. Wadsworth, 2014.
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MD, Ira H. Kirschenbaum. The CJR Manual : Bundled Payments Program: Point-by-Point. Createspace Independent Publishing Platform, 2015.
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Kakalik, James, Terence Dunworth, Laural Hill, Daniel McCaffrey, Marian Oshiro, Nicholas Pace, and Mary Vaiana. Just, Speedy, and Inexpensive? An Evaluation of Judicial Case Management Under the CJRA. RAND Corporation, 1996. http://dx.doi.org/10.7249/rb9027.
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Dialogos sobre justiça restaurativa reflexoes entre gejur uepg e cjr oabsp. Texto e contexto editora, 2021. http://dx.doi.org/10.54176/osjn1642.
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Lambert, Simon M. Instability. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.004007.
Повний текст джерелаАнотація:
♦ The fundamental principle or essence of the shoulder is concavity compression. Stability of the shoulder is the condition in which a balanced centralizing joint reaction force (CJRF) exists to maintain concavity compression of the glenohumeral joint whatever the position of the limb and hand.♦ Instability is a symptom. It can be defined as the condition of symptomatic abnormal motion of the joint. It refers to a perturbation of concavity compression. It is not a diagnosis.♦ Instability is the result of perturbations of structural factors and non-structural factors.♦ The clinical syndrome of instability is a disturbance of one or more of these factors in isolation or together. The relative importance of each factor to the syndrome can change over time. The relationship between these factors is described by the Stanmore triangle.♦ Both structural and non-structural factors can be perturbed by arrested or incomplete development (dysplasia) or by injury (disruption).♦ The aim of treatment is the restoration of (asymptomatic) stable motion by restoration of the CJRF and so restoration of the condition of concavity compression.♦ Management follows simple principles: surgery should be undertaken within the context of a well-considered rehabilitation program largely centred around optimizing rotator cuff function.♦ Failures of management are often due to failure of or incomplete diagnosis, failure of healing, inadequate attention to patient- and pathology- specific rehabilitation programs, or insufficient attention to lifestyle considerations.♦ Disrupted anatomy is restored, preferably by anatomic operations with predictably good outcomes. Dysplastic anatomy is augmented, often by non-anatomic operations with less predictable outcomes. Revision stabilizations are generally nonanatomic, and have higher failure rates.
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Reston, James Jr. The Conviction of Richard Nixon: The Untold Story of the Frost/Nixon Interviews. RH Audio, 2007.
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The Conviction of Richard Nixon: The Untold Story of the Frost/Nixon Interviews. Harmony, 2007.
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The Conviction of Richard Nixon: The Untold Story of the Frost/Nixon Interviews. Three Rivers Press, 2008.
Знайти повний текст джерелаЧастини книг з теми "CJRj"
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Duan, Xingyi, Baoxin Wang, Ziyue Wang, Wentao Ma, Yiming Cui, Dayong Wu, Shijin Wang, et al. "CJRC: A Reliable Human-Annotated Benchmark DataSet for Chinese Judicial Reading Comprehension." In Lecture Notes in Computer Science, 439–51. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-32381-3_36.
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Cornell, Nica. "CJR." In Best New African Poets 2019 Anthology, 175. Mwanaka Media and Publishing, 2020. http://dx.doi.org/10.2307/j.ctv1b74285.134.
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"32. CJR—From New Management to Old." In Pulitzer's School, 206–11. Columbia University Press, 2003. http://dx.doi.org/10.7312/boyl13090-032.
Повний текст джерелаТези доповідей конференцій з теми "CJRj"
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Borges, Alice, Fernanda de Sousa, Maristela Holanda, Aleteia P. F. Araujo, Carla Cavalcante Koike, and Roberta B. Oliveira. "Participação Feminina na Empresa Júnior de Computação - CJR da Universidade de Brasília." In Women in Information Technology. Sociedade Brasileira de Computação, 2021. http://dx.doi.org/10.5753/wit.2021.15852.
Повний текст джерелаАнотація:
Mulheres têm pouca inserção na área de Computação. Este é um problema não apenas no Brasil, mas também em diferentes países do mundo. A falta de diversidade de gênero em cursos de Computação no ensino superior no Brasil é reportada em diferentes artigos, e isso reflete diretamente no mercado de trabalho. Uma iniciativa que tem levado os estudantes universitários a inserir-se no mercado de trabalho durante a universidade é o movimento de empresas juniores. Neste contexto, este artigo apresenta uma análise da participação feminina na CJR, uma empresa júnior do Departamento de Ciência da Computação da Universidade de Brasília (UnB). Além de descrever ações para aumentar a representativa feminina na empresa, como ação para seleção com tema de princesas e o processo de seleção ser realizado por mulheres. Após essas ações os resultados foram que a parte de liderança da empresa á ocupada por 50% de mulheres e o número de alunas passou de 2% em 2018, para 16% em 2020.
Звіти організацій з теми "CJRj"
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Bakhtaoui, Inès, Zoha Shawoo, Alpha Amadou Diallo, Ashish Barua, Ayesha Dinshaw, Ireen Twongirwe, Lameck Nkhoma, et al. How small and locally led grants can address loss and damage: early lessons from the Scottish government’s 2021 funding commitment. Stockholm Environment Institute, December 2023. http://dx.doi.org/10.51414/sei2023.061.
Повний текст джерелаАнотація:
The authors assessed and evaluated how the first GBP 1 million of Scottish government funding was disseminated and used, in the form of small grants for locally led action, and how this can inform the operationalization of both the L&D fund and L&D finance more broadly, in time for discussions at the 28th UN Climate Change Conference of Parties (COP28) on climate change. Vulnerable countries and communities already face losses and damages as a result of climate change, and they urgently need financial support to enable recovery from trauma and lost homes, lives and livelihoods. At the 26th UN Climate Change Conference of Parties in Glasgow (COP26), Scotland made history as the first Global North country to pledge bilateral finance specifically for addressing climate-related loss and damage (L&D). This report gathers 16 lessons under six overarching themes, from the dissemination of L&D funding through the Climate Justice Resilience Fund (CJRF). Included are recommendations for L&D finance, as well as for climate negotiators who will discuss how the new L&D Fund will be operationalized at COP28, beginning at the end of November in Dubai. These findings shed light on the benefits and limitations of small grants for locally led action, what trade-offs might manifest when implementing locally led approaches, and how L&D finance can be used in a manner that can reach and serve vulnerable and affected groups.