Готові списки джерел за темами / CIN (cervical intraepithelial neoplasia)

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Добірка наукової літератури з теми "CIN (cervical intraepithelial neoplasia)"

Автор: Grafiati

Опубліковано: 10 березня 2023

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Статті в журналах з теми "CIN (cervical intraepithelial neoplasia)"

Wang, Yinhai, Danny Crookes, Osama Sharaf Eldin, Shilan Wang, Peter Hamilton, and Jim Diamond. "Assisted Diagnosis of Cervical Intraepithelial Neoplasia (CIN)." IEEE Journal of Selected Topics in Signal Processing 3, no. 1 (February 2009): 112–21. http://dx.doi.org/10.1109/jstsp.2008.2011157.

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Koonings, P. P., G. d'Ablaing, J. B. Schlaerth, C. P. MorRow, and J. P. Curtin. "Cervical intraepithelial neoplasia (CIN) following cryotherapy failure." Gynecologic Oncology 40, no. 2 (February 1991): 188. http://dx.doi.org/10.1016/0090-8258(91)90200-o.

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Atkin, Niels B., and Marion C. Baker. "DNA ploidy of cervical intraepithelial neoplasia (CIN)." Cancer Genetics and Cytogenetics 94, no. 2 (April 1997): 151–52. http://dx.doi.org/10.1016/s0165-4608(96)00212-9.

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Das, Reba, Mahfuza Jebun Mouri, Ratim Mir, Shahnaj Begum, Nondita Mudi, and Enamul Kabir. "Expression of p63 in Cervical Intraepithelial Neoplasia (CIN) and Cervical Cancer." Sir Salimullah Medical College Journal 29, no. 2 (April 7, 2022): 141–46. http://dx.doi.org/10.3329/ssmcj.v29i2.58973.

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Анотація:

Background: Cervical cancer is a major public health problem worldwide. Persistent infection with High-Risk Human Papilloma Virus (HPV) has been the main cause of squamous intraepithelial neoplasia which in turn leads to invasive squamous cell carcinoma. p63 is necessary for the activation of HPV, epithelial proliferation and differentiation. It also regulates the expression of certain cell cycle regulators. It has been reported that, from CIN I to CIN III, p63 expression increases progressively from basal layer to surface. In squamous cell carcinoma, it is expressed throughout the entire thickness of the tumor. Thereby it plays a significant role in diagnosing cervical premalignant and malignant lesions. Objective: To evaluate the relationship of p63 expression with different grades of CIN & invasive SCC. Method: Total 86 paraffin embedded tissue blocks of histopathologically diagnosed cases of CIN and cervical cancer were evaluated by immunohistochemical staining for p63 expression. The study was performed in Sir Salimullah Medical College, Dhaka (from March, 2018 to February, 2020). Statistical analyses were carried out by using SPSS version 22 for Windows. A descriptive analysis was performed for all data. Observations were indicated by frequencies and percentages. Statistical significance was set at “p” value <0.05. Results: Present study showed progressive increase in p63 expression from CIN I to CIN III from basal layer to surface. In invasive squamous cell carcinoma, higher expression of p63 was noted throughout the entire thickness of the tumor. No expression was seen in cervical adenocarcinoma and small cell carcinoma. In adenosquamous carcinoma only the area showing squamous differentiation revealed positive p63 expression. Statistically significant association of p63 expression was found with parity of patients and among grades of CIN . Conclusion: The results of this current study revealed that, p63 has significant association among different grades of CIN. It is also a useful marker in confirming a poorly differentiated squamous cell carcinoma & predicting the progression of a squamous neoplastic lesion from cervical intraepithelial neoplasia to invasive squamous cell carcinoma. Moreover, it is useful to differentiate invasive squamous cell carcinoma from cervical adenocarcinoma. Sir Salimullah Med Coll J 2021; 29(2): 141-146

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ROKITA, WOJCIECH. "Topography of the cervical intraepithelial neoplasia in women." PRZEGLĄD GINEKOLOGICZNO-POŁOŻNICZY 6, no. 2 (May 23, 2006): 95–98. http://dx.doi.org/10.1066/s10014060005.

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Hasegawa, Kazuo, Ryuichiro Nisimura, Masaaki Yamasaki, Satoshi Yamaguchi, Yoshio Tenjin, Tadashi Sugishita, Tetsuya Muroya, and Hotaka Sakunaga. "Study on Photodynamictherapy for Cervical Intraepithelial Neoplasia (CIN)." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 17, Supplement (1996): 357–60. http://dx.doi.org/10.2530/jslsm1980.17.supplement_357.

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Herich, Olena, Olha Horbatiuk, Anatoliy Hryhorenko, Larysa Dudikova, Alla Kondratiuk, Anelia Shatkovska, Alla Binkovska, and Valeriy Garbuziuk. "Modern Conservative Etiopathogenetic Treatment of Cervical Intraepithelial Neoplasia (literature review)." Reports of Vinnytsia National Medical University 24, no. 2 (October 12, 2020): 332–38. http://dx.doi.org/10.31393/reports-vnmedical-2020-24(2)-23.

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Анотація:

Annotation. We used PubMed, Cochrane Library, Google Scholar databases, mostly referring to publications from the last five years (2016–2020). The long-term persistence of oncogenic types of human papilloma virus is the main etiological factor for cervical intraepithelial neoplasia (CIN). Prolonged persistence of herpes infection can also have a transformative effect on cervical epithelium. Since this pathology is most often diagnosed in women of reproductive age, the maximum preservation of reproductive function, prevention of perinatal complications requires the search for new conservative CIN treatments aimed at the complete elimination of viruses and neoplastic cells. The effectiveness of conservative antiviral therapy of CIN I, II without the use of surgical methods has been proved, especially in women who have not fulfilled their reproductive plans. In addition, antiviral therapy during pre- and postoperative periods contributes to the reduction of complications and relapses in women with severe cervical neoplasia.

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Khanam, Afroza, Zannatul Ferdous Jesmin, Fauzia Begum, N. Akhter, Mst Akter, Shamsun Nahar, AR Barua, and A. Nessa. "Prevalence of Cervical Intraepithelial Neoplasia (CIN) at Khulna Division of Bangladesh." Bangladesh Journal of Obstetrics & Gynaecology 33, no. 1 (September 22, 2019): 21–28. http://dx.doi.org/10.3329/bjog.v33i1.43270.

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Back ground: Cervical cancer is the most common genital tract cancer and the important cause of cancer death among Bangladeshi women. Information about actual number of women living with preinvasive phase of cervical cancer and their diagnosis and treatment is limited. For strengthening the programme and policy for cervical cancer prevention , the baseline prevalence of cervical intraepithelial neoplasia ( CIN) need to be assessed. Methods: This population based study aimed to determine the prevalence of CIN among women of Khulna division of Bangladesh. Data has been collected from four upazila of four districts of Khulna division. VIA and colposcopy and histopathology was used for detection of cervical pre-cancers and early cancers among 1232 women of the mentioned population. Results: Crude prevalence of CIN was 5.84 %,CIN-II 1.1% and CIN- III .73% in colposcopically directed biopsy. Ninety two participants with CIN received treatment at the Colposcopy Clinic of Obstetrics and Gynaecology department of Khulna Medical College Hospital (KMCH). Conclusion: This population based prevalence study of CIN and socio demography would have conducive effect on future cervical cancer prevention programme. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 21-28

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Mkrtchian, Liana S., Liudmila Iu Grivtsova, Valentina I. Kiseleva, Anna M. Aleshina, and Liudmila I. Krikunova. "Comprehensive treatment of cervical intraepithelial neoplasia." Gynecology 23, no. 1 (March 21, 2021): 62–67. http://dx.doi.org/10.26442/20795696.2021.1.200670.

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Aim. To study the effectiveness of the use of Neovir (sodium oxodihydroacridinyl acetates) as immunomodulatory and antiviral drug in the comprehensive treatment of various grade cervical intraepithelial neoplasia (CIN). Study design: prospective comparative study. Materials and methods. The study included 60 patients (mean age 34.78.2 years) with morphologically verified various grade CIN, who were received comprehensive treatment, including the use of Neovir (sodium oxodihydroacridinyl acetate) as the drug with immunomodulatory and antiviral activity, 250 mg/2 ml intramuscularly every 48 hours, 10 injections before (group 1) or after (group 2) multi-stage radiosurgical diagnostic and treatment procedure or only a similar surgical intervention (group 3). All patients underwent complete clinical, morphological and laboratory examination with monitoring for the presence of high-risk human papillomavirus (HPV) in the cervical scraping and the dynamics of peripheral blood lymphocyte subpopulations. Results. Dynamic follow-up showed that in a month after surgery, patients who were treated with radiosurgical resection as monotherapy (group 3) had the lowest rate of complete epithelialization of the cervical stump 30.0% vs 55.0 and 65,0% in the group 1 and group 2 respectively. In this group, the proportion of patients with persistent viral infection was 1.52 times higher than in the groups where an antiviral drug was used in combination with radiosurgical intervention 35.7% vs 17.6 and 22.2% in the group 1 and group2, respectively. In 6 months, elimination of high-risk HPV in groups with comprehensive treatment reached 94.5 in the group 1 and 94.1% in the group 2 (p0.05) vs 78.6% in the group 3. The lowest number of TNK- and NK-cells was found in the group of patients who received radiosurgical treatment as monotherapy, which correlated with the highest incidence of high-risk HPV persistence after treatment in this group. Conclusions. In patients with various grade CIN, the use of an immunomodulatory drug with antiviral activity in combination with radiosurgical intervention promotes early epithelialization of the cervix and elimination of high-risk HPV, which is confirmed by significant changes in the lymphocyte subpopulations which provide antiviral immunity.

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Vinogradova, O. P., N. A. Andreeva, O. I. Artemova, and O. V. Epifanova. "Cervical Stage II Intraepithelial Neoplasia: Antivirals Efficacy." Doctor.Ru 21, no. 1 (2022): 54–58. http://dx.doi.org/10.31550/1727-2378-2022-21-1-54-58.

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Study Objective: To assess the efficacy of an antiviral in the management of HPV-associated cervical stage II intraepithelial neoplasia (CIN II), using the analysis of the apoptotic marker levels and cytokine profile — caspase 3 and 9, interferon (INF) γ, interleukin (IL) 18. Study Design: Perspective study. Materials and Methods. We examined 126 women of reproductive age. The study included two groups: controls (40 relatively healthy fertile women without any cervical pathologies and HPV) and a group of 86 women with HPV-associated CIN II. All subjects underwent an examination; and their cytokine response and apoptotic marker level were assessed. All patients in CIN II group had the affect area excised. 43 post-excision women were followed up (sub-group A); other 43 subjects had surgery and an antiviral (sub-group B). The antiviral was administered subcutaneously once daily, 3 injections before and 3 injections after the excision. The primary efficacy criteria were absence of HPV or reduction in the viral load below significant values, and absence of pathology relapses after 6 and 12 months of the study. Study Results. In subjects with CIN II, pre-therapy caspase 3 and 9 levels were significantly higher vs controls; INF-γ was 1.8 times higher than in controls, and mean IL-18 concentration was considerably lower (p < 0.05 in both cases). In sub-groups A and B, caspase 3 and 9 concentration in 3 and 6 months after therapy also differed significantly from controls, and in 6 months, caspase 3 and 9 concentration in sub-group В was considerably lower than in sub-group А. Women in sub-groups А and В demonstrated statistically significant difference in cytokine profile: in both sub-groups, INF-γ concentration in 10 days increased, while in 12 months it almost reached its baseline value. IL-18 in sub-group B in 10 days and 12 months was significantly higher than in sub-group А. Conclusion. The results of the study demonstrate high HPV elimination and reduction in relapse probability after excision in patients with CIN II with the use of antivirals. Keywords: human papilloma virus, cervical intraepithelial neoplasia, caspase 3, caspase 9, apoptosis, cytokines, interleukin18, tumour necrosis factor α, interferon γ, cervical cancer, genetic typing, high risk of cancer.

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Більше джерел

Дисертації з теми "CIN (cervical intraepithelial neoplasia)"

ROTONDO, John Charles. "Mechanism of progression in cervical intraepithelial neoplasia." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389088.

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The cervical intraepithelial neoplasia (CIN) grade 1, 2 and 3 are the precursor lesions of cervical cancer. Due to the lack of useful study models, the molecular mechanisms involved in CIN progression are still largely unknown. The overall aim of my study was to investigate the molecular mechanisms occurring in CIN lesion progression. This goal was achieved by investigating gene expression profiles and methylation status of gene promoters in a novel study model of tumor progression, i.e. primary colonies of CIN2 and CIN3 keratinocytes derived from CIN2 and CIN3 lesions. To this purpose, the first aim of my study was to develop a rapid and simple cell culture protocol enables primary colonies of HPV16-CIN2 and HPV16-CIN3 keratinocytes to be derived from small tissue fragments of CIN2 and CIN3 lesions. The primary colonies of CIN2 and CIN3 keratinocytes were then investigated for presence epithelial and cervical markers showing cytokeratin -14, -17, -19 expression. In the second part of my study primary colonies of HPV16-CIN2 and HPV16-CIN3 keratinocytes were chosen to be investigated by microarray analysis. Differentially expressed genes were analyzed in normal cervical keratinocytes compared with HPV16-CIN2 keratinocytes and in HPV16-CIN2 keratinocytes compared with HPV16-CIN3 keratinocytes. Thirty-seven candidate genes with continuously decreasing or increasing expression during CIN progression were identified. Specifically, 23 down-expressed genes involved in antiviral immune response and differentiation and 14 over-expressed genes involved in proliferation and tumor invasiveness were identified. One of these genes, phosphoglycerate dehydrogenase, was chosen for further characterization. Quantitative reverse transcription-polymerase chain reaction and immunohistochemical analysis confirmed that expression of phosphoglycerate dehydrogenase consistently increases during progression of HPV16-CIN toward cancer. Phosphoglycerate dehydrogenase is likely to be associated with tumorigenesis and may be a potential prognostic marker for CIN progression. Finally, in the third part of my study, to verify whether down-expression of genes in CIN2 and CIN3 keratinocytes depended on DNA promoter methylation, I investigated the methylation status of RARB and IRF6 promoter, both tumor suppressor genes, in relationship with expression of their two pathway-correlated genes, p63 and c-JUN. The epigenetic analysis revealed a hypermethylation of RARB and IRF6 gene promoters in CIN2 and CIN3 keratinocytes compared to normal keratinocytes as well as a progressive hypermethylation of RARB promoter region from normal to CIN2 keratinocytes and from CIN2 to CIN3 keratinocytes. Consistently, a gradual up-regulation of p63 and c-JUN from CIN2 to CIN3 keratinocytes was detected. It is conceivable that the hypermethylation of RARB and IRF6 promoter region may cause a consequent RARB and IRF6 down-regulation and this reduction of expression could enhance c-JUN and p63 expression in CIN keratinocytes. In conclusion, in my study the molecular mechanisms occurring in CIN lesions progression were investigated. In particular, it was investigated gene expression profiles and methylation status of gene promoters in a novel study model, i.e. primary colonies of CIN2 and CIN3 keratinocytes derived from CIN2 and CIN3 lesions. Gene expression analysis revealed 37 down-expressed or over-expressed genes which may contribute to CIN progression. One of these genes, the phosphoglycerate dehydrogenase, which resulted over-expressed at both mRNA and protein level in CIN2 and CIN3 keratinocytes and in CIN2, CIN3 and cancer tissues, respectively, is likely to be associated with tumorigenesis and may be a potential prognostic marker for CIN progression. Aberrant promoter hypermethylation of RARB and IRF6 genes also may be a potential epigenetic prognostic marker for CIN progression.

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Keenan, Stephen J. "Quantitative analyses and classification of cervical intraepithelial neoplasia (CIN) using automated machine vision." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368597.

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Flynn, Sarah E. "SHAME, GUILT, AND KNOWLEDGE OF HPV IN WOMEN RECENTLY DIAGNOSED WITH HPV-RELATED CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN)." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/10.

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The current study investigated the relationships between state shame, guilt, and disease knowledge in women recently diagnosed with cervical intraepithelial neoplasia (CIN) caused by the human papillomavirus (HPV). Recent research has indicated that diagnosis of HPV can elicit negative self-directed affect, including persistent experiences of shame. Studies have also shown that knowledge of HPV is low in the general population, even though it is the most common sexually transmitted infection. It is important to understand how shame affects those with HPV because shame is related to a decline in important immune parameters that may be essential in HPV clearance. A sample of young women (ages 18-28) recently diagnosed with HPV were given measures of shame and guilt-proneness, state shame and guilt, depression, impact of diagnosis, and HPV knowledge. A comparison group of women diagnosed with infectious mononucleosis caused by the Epstein-Barr Virus (EBV) were also given these measures. It was predicted that women diagnosed with HPV would have higher levels of shame and guilt than women diagnosed with EBV. It was also predicted that disease knowledge would moderate negative affect in women with HPV, where increases in HPV knowledge would neutralize feelings of shame and guilt. The results of this study supported the first hypothesis: women with HPV experienced more shame and guilt than women with EBV. Shame largely mediated the relationship between diagnosis of HPV and depression, as well as HPV and distress, but these relationships were not significant for guilt. The hypothesis that disease knowledge would moderate feelings of shame was not supported in this study. Because of the biological and psychological consequences of shameful experiences, research should continue to measure factors that may predict shame after diagnosis of HPV.

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Nath, Rahul. "An Investigation into the prevalence of abnormal cervical smears and cervical intraepithelial neoplasia (CIN) in women with systemic lupus erythematosus (SLE)." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438963.

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Elfgren, Kristina. "Longitudinal studies of human papillomavirus infection : with special reference to screening for cervical cancer and treatment of CIN /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-673-1/.

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Wang, Y. "Computer assisted diagnesis of cervical intraepithelicel neoplasia (CIN) using histological virtual slides." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492486.

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This thesis proposes a prototype automated computer-assisted system for the diagnosis of CIN using ultra-large virtual slides (up to 120Kx80K pixels at a resolution of 0.25 !-un/pixel). The system is in two parts: the segmentation of squamous epithelium, and the subsequent diagnosis of CIN. For the segmentation of squamous epithelium, to save processing time, a multiresolution method is developed to segment ultra-large cervical virtual slides. The squamous epithelium layer is first segmented at a low resolution, and the boundaries are further fine tuned at a higher resolution. The block-based segmentation method uses robust texture features in ~ombination with a Support Vector Machine (SVM) to perform classification. Medical histology rules are finally applied to remove misclassifications. In tests using 31 virtual slides the segmentation achieves an average accuracy of more than 94.25%. For the diagnosis of CIN, so-called 'connecting lines', along the direction of possible progression of CIN in the epithelial layer, are firstly identified. Four connecting line features are developed based on morphological characteristics of nuclei. Using multicategory SVM, connecting lines are classified into Normal, CIN I, CIN II, and CIN III. The final diagnosis for a slide region is based on combining the classification of connecting lines in the region.. The robustness of the system in term of regional diagnosis is measured against slides manually classified by two pathologists. Interobserver variability is considered. Results indicate that the system offers a promising basis for a computer-assisted diagnostic tool. It main limitation is seen to be in the selection of more extensive and more varied training data.

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Carrasco, García Miguel Ángel. "Neoplasia Intraepitelial Cervical grado II y III: Estudio morfométrico de sus diferencias y relación con el Virus del Papiloma Humano." Doctoral thesis, Universitat Internacional de Catalunya, 2010. http://hdl.handle.net/10803/9355.

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El propòsit del nostre treball és valorar morfomètricament les diferències existents entre la Neoplàsia Intraepitelial Cervical (CIN) grau 2 i 3, així com el tipus de Virus del Papil·loma Humà (VPH) present, estudiat mitjançant Hibridació in situ.
Hem estudiat 66 peces quirúrgiques d'exèresi del coll uterí de pacients amb diagnòstic histològic de CIN 2 i 82 de CIN 3. Hem demostrat amb el nostre estudi que la superfície afectada en el coll cervical per CIN 3 és significativament més gran que la de CIN 2, a la vegada que són lesions longitudinalment majors, amb major afectació glandular, major profunditat en l'afectació glandular i major índex mitòtic. També hem pogut demostrar que VPH 16/18 predomina en CIN 3. No hem trobat diferències significatives en quant a la presència de papil·les vasculars en ambdues lesions i tampoc hem trobat relació entre tipus de VPH i àrea afectada per CIN, així com entre tipus de VPH i edat de la pacient.
El propósito de nuestro trabajo es valorar morfométricamente las diferencias existentes entre la Neoplasia Intraepitelial Cervical (CIN) grado 2 y 3, así como el tipo de Virus del Papiloma Humano (VPH) presente, estudiado mediante Hibridación in Situ.
Hemos estudiado 66 piezas quirúrgicas de exéresis del cuello cervical de pacientes con diagnóstico histológico de CIN 2 y 82 de CIN 3. Hemos demostrado con nuestro estudio que la superficie afectada en el cuello cervical por CIN 3 es significativamente mayor que la de CIN 2, a la vez que son lesiones longitudinalmente mayores, con mayor afectación glandular, mayor profundidad en la afectación glandular y mayor índice mitótico. También hemos podido demostrar que VPH 16/18 predomina en CIN 3. No hemos encontrado diferencias significativas en cuanto a la presencia de papilas vasculares en las dos lesiones y tampoco hemos encontrado relación entre tipo de VPH y área afectada por CIN, así como entre tipo de VPH y edad de la paciente.

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Miranda, Gisele Helena Barboni. "Método para processamento e análise computacinal de imagens histopatológicas visando apoiar o diagnóstico de câncer de colo de útero." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-24012012-154506/.

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A histopatologia é considerada um dos recursos diagnósticos mais importantes na prática médica e caracteriza-se pelo estudo das alterações estruturais e morfológicas das células e dos tecidos causadas por doenças. Atualmente, o principal método utilizado no diagnóstico histopatológico de imagens microscópicas, obtidas por meio de amostras em exames convencionais, é a avaliação visual do patologista, a qual se baseia na experiência do mesmo. O uso de técnicas de processamento computacional de imagens possibilita a identificação de elementos estruturais e a determinação de características inerentes, subsidiando o estudo da organização estrutural das células e de suas variações patológicas. A utilização de métodos computacionais no auxílio ao diagnóstico visa diminuir a subjetividade do processo de avaliação e classificação realizado pelo médico. Diferentes características dos tecidos podem ser mapeadas por meio de métricas específicas que poderão ser utilizadas em sistemas de reconhecimento de padrões. Dentro desta perspectiva, o objetivo geral deste trabalho inclui a proposta, a implementação e a avaliação de um método para a identificação e a análise de estruturas histológicas, a ser utilizado para a análise de lesões neoplásicas do colo do útero (NICs) a partir de amostras histopatológicas. Este trabalho foi desenvolvido em colaboração com uma equipe de patologistas, especialistas do domínio. As imagens microscópicas digitalizadas foram adquiridas a partir de lâminas previamente fixadas, contendo amostras de biópsias. Para segmentação dos núcleos celulares, foi implementado um pipeline de operadores morfológicos. Métodos de segmentação baseados em cor também foram testados e comparados à abordagem morfológica. Foi proposta e implementada uma abordagem baseada em camadas para representação do tecido, adotando-se a Triangulação de Delaunay (TD) como modelo de grafo de vizinhança. A TD apresenta algumas propriedades particulares que permitem a extração de métricas específicas. Foram utilizados algoritmos de agrupamento e morfologia de grafos, adotando-se critérios de semelhança e relações de adjacência entre os triângulos da rede, a fim de se obter a fronteira entre as camadas histológicas do tecido epitelial de forma automática. As seguintes métricas foram extraídas dos agrupamentos resultantes: grau médio, entropia e taxa de ocupação dos triângulos da rede. Finalmente, foi projetado um classificador estatístico levando-se em consideração os diferentes agrupamentos que poderiam ser obtidos a partir das imagens de treinamento. Valores de acurácia, sensitividade e especificidade foram utilizadas para avaliação dos resultados obtidos. Foi implementada validação cruzada em todos os experimentos realizados e foi utilizado um total de 116 imagens. Primeiro, foi avaliado a acurácia da metodologia proposta na determinação correta da presença de anomalia no tecido, para isto, todas as imagens que apresentavam NICs foram agrupadas em uma mesma classe. A maior taxa de acurácia obtida neste experimento foi de 88%. Em uma segunda etapa, foram realizadas avaliações entre as seguintes classes: Normal e NIC-I; NIC-I e NIC-II, e, NIC-II e NIC-III, obtendo-se taxas de acurácia máximas de 73%, 77% e 86%, respectivamente. Além disso, foi verificada também, a acurácia na discriminação entre os três tipos de NICs e regiões normais, obtendo-se acurácia de 64%. As taxas de ocupação relativas aos agrupamentos representativos das camadas basais e superficiais, foram os atributos que levaram às maiores taxas de acurácia. Os resultados obtidos permitem verificar a adequação do método proposto na representação e análise do processo de evolução das NICs no tecido epitelial do colo uterino.
Histopathology is considered one of the most important diagnostic tools in medical routine and is characterized by the study of structural and morphological changes of the cells in biological tissues caused by diseases. Currently, the visual assessment of the pathologist is the main method used in the histopathological diagnosis of microscopic images obtained from biopsy samples. This diagnosis is usually based on the experience of the pathologist. The use of computational techniques in the processing of these images allows the identification of structural elements and the determination of inherent characteristics, supporting the study of the structural organization of tissues and their pathological changes. Also, the use of computational methods to improve diagnosis aims to reduce the subjectivity of the evaluation made by the physician. Besides, different tissue characteristics can be mapped through specific metrics that can be used in pattern recognition systems. Within this perspective, the overall objective of this work includes the proposal, the implementation and the evaluation of a methodology for the identification and analysis of histological structures. This methodology includes the specification of a method for the analysis of cervical intraepithelial neoplasias (CINs) from histopathological samples. This work was developed in collaboration with a team of pathologists. Microscopic images were acquired from blades previously stained, containing samples of biopsy examinations. For the segmentation of cell nuclei, a pipeline of morphological operators were implemented. Segmentation techniques based on color were also tested and compared to the morphological approach. For the representation of the tissue architecture an approach based on the tissue layers was proposed and implemented adopting the Delaunay Triangulation (DT) as neighborhood graph. The DT has some special properties that allow the extraction of specific metrics. Clustering algorithms and graph morphology were used in order to automatically obtain the boundary between the histological layers of the epithelial tissue. For this purpose, similarity criteria and adjacency relations between the triangles of the network were explored. The following metrics were extracted from the resulting clusters: mean degree, entropy and the occupation rate of the clusters. Finally, a statistical classifier was designed taking into account the different combinations of clusters that could be obtained from the training process. Values of accuracy, sensitivity and specificity were used to evaluate the results. All the experiments were taken in a cross-validation process (5-fold) and a total of 116 images were used. First, it was evaluated the accuracy in determining the correct presence of abnormalities in the tissue. For this, all images presenting CINs were grouped in the same class. The highest accuracy rate obtained for this evaluation was 88%. In a second step, the discrimination between the following classes were analyzed: Normal/CIN 1; CIN 1/CIN 2, and, CIN 2/CIN 3, which represents the histological grading of the CINs. In a similar way, the highest accuracy rates obtained were 73%, 77% and 86%, respectively. In addition, it was also calculated the accuracy rate in discriminating between the four classes analyzed in this work: the three types of CINs and the normal region. In this last case, it was obtained a rate of 64%.The occupation rate for the basal and superficial layers were the attributes that led to the highest accuracy rates. The results obtained shows the adequacy of the proposed method in the representation and classification of the CINs evolution in the cervical epithelial tissue.

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CAFFARINI, MIRIAM. "Mesoderm stem cells and inflammation: role in the Pathogenesis and potential therapy of selected Gynecological Deseases and primary Myopathies." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263543.

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Le cellule staminali mesenchimali (MSCs) sono un tipo specifico di cellule staminali adulte con un elevato potenziale proliferativo e differenziativo verso cellule specializzate di derivazione mesodermica. Le MSCs svolgono anche una funzione paracrina attraverso il rilascio di molteplici fattori di crescita, chemochine e citochine. Le MSCs si comportanto da sentinelle che percepiscono il microambiente e agiscono di conseguenza, passando da un fenotipo pro-infiammatorio ad uno immunosoppressivo in base ai segnali che ricevono. Nel seguente lavoro sono valutati l’esistenza e il ruolo delle MSCs nella patogenesi e nella potenziale terapia di selezionate patologie ginecologiche con una componente infiammatoria come il leiomioma uterino, la neoplasia intraepiteliale cervicale (CIN) e in miopatie primarie, quali la Distrofia Muscolare di Duchenne (DMD). Nel primo studio, sono state identificate le cellule progenitrici nel leiomioma e nel miometrio sano ed è stata investigata la correlazione tra tali cellule e l’infiammazione nell’insorgenza del leiomioma. I dati suggeriscono che una overespressione di citochine relative all’infiammazione cronica nei progenitori del leiomioma potrebbe favorire un microambiente adeguato per l’insorgenza di questa patologia. Nel secondo studio, le MSCs sono state isolate da cervici di pazienti giovani (yC-MSCs) e pazienti vecchie (oC-MSCs) e i risultati mostrano come la loro immunobiologia sia condizionata dall’età dei donatori, influenzando anche il tasso di regressione della CIN. Inoltre, nel crosstalk con le cellule HeLa, yC-MSCs svolgono maggiormente un ruolo anti-tumorale sostenendo un’infiammazione acuta. L’obiettivo del terzo studio è stato quello di trovare una corretta strategia per aumentare la produzione di distrofina nella DMD mediante terapia genica. Pertanto, i mioblasti isolati da donatori di DMD sono stati trasdotti con la proteina fluorescente verde (GFP) e un vettore lentivirale esprimente l’snRNA per indurre il salto dell’esone; i dati indicano che i mioblasti trasdotti erano abili a differenziare in senso miogenico esprimendo la distrofina funzionale.
Mesenchymal stem or stromal cells (MSCs) are a specific type of adult stem cells with an extensive proliferation and differentiation potential towards specialized cells developing from the mesoderm. MSCs are also characterized by paracrine function through the release of multiple growth factors, chemokines and cytokines. MSCs play as sentinel that feel the microenvironment and act consequently, switching from a pro-inflammatory phenotype to an immunosuppressive phenotype according to the signals they receive. In the present work the existence and the role of MSCs in the pathogenesis and potential therapy of selected gynecological diseases with an inflammatory component as uterine leiomyoma, cervical intraepithelial neoplasia (CIN), and in primary myopathies, as Duchenne Muscular Dystrophy (DMD) were evaluated. In the first study, progenitor cells were identified both in leiomyomas and normal myometrium, and the correlation between these cells and inflammation in leiomyoma onset has been investigated. The data suggest that the upregulation of cytokines related to chronic inflammation in leiomyoma progenitors could favour a microenvironment suitable for the onset of this pathology. In the second study, MSCs from cervix of young (yC-MSCs) and old patients (oC-MSCs) were isolated and results show as their immunobiology is affected by the age of donors, influencing in turn the regression rate of CIN. In addition, in the crosstalk with HeLa cells, yC-MSCs play an anti-tumoral role sustaining an acute inflammatory environment. The goal of the third study was to find a correct strategy to enhance the production of dystrophin protein in DMD through gene therapy. Therefore, myoblasts isolated from DMD donor were transduced with green fluorescent protein (GFP) and a lentiviral vector expressing the snRNA to induce exon skipping; data indicate that transduced myoblasts were able to perform myogenic differentiation expressing a functional dystrophin protein.

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Giannoudis, Athina. "Human papillomaviruses in squamous intraepithelial lesions of the cervix." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250230.

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Книги з теми "CIN (cervical intraepithelial neoplasia)"

A, Jordan Joseph, Luesley David, and Richart Ralph M. 1933-, eds. Intraepithelial neoplasia of the lower genital tract. Edinburgh: Churchill Livingstone, 1995.

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S, Cibas Edmund, and Lee Kenneth R. 1941-, eds. Pathology of early cervical neoplasia. New York: Churchill Livingstone, 1997.

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Zavaleta, Leticia Rocha. Immune response to human papillomavirus (HPV) in cervical cancer and cervical intraepithelial neoplasia. Manchester: University of Manchester, 1996.

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Weglarz, Michele C. The distribution of AgNORs in cervical biopsies: An aid to grading cervical intraepithelial neoplasia using an image analysis system. [S.l: The Author], 1991.

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Boyd, Jennifer Lorraine Roberta. Morphometric analysis as an aid in distinguishing Cervical Intraepithelial Neoplasia Grade III from Invasive Carcinoma. [S.l: The Author], 1992.

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Baron, Mary Michele. Fractal characterisation of nuclear morphology in cervical intraepithelial neoplasia (dysplasia and carcinoma in situ) in humans. Sudbury, Ont: Laurentian University, 1994.

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Lal, Mira. Women’s psychosomatic health promotion and the biopsychosociocultural nexus. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198749547.003.0008.

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Chapter 8 discusses the promotion of women's psychosomatic health by prevention or early treatment of cancer and obesity. Health providers have to consider the biological, psychological, social, and cultural factors that alter psychosomatic interactions to generate these health conditions. Primary/secondary prevention need more emphasis than tertiary prevention or treatment. The transition of normal cervical epithelium to cervical-intraepithelial neoplasia (CIN), and the progression of CIN 2/3 to cancer is preventable. Two-thirds of patients with CIN have HPV infection. Cervical screening allows astute clinical decision-making as CIN could revert back to normal epithelium. Colposcopically-directed early treatment of CIN 2/3 is a secondary preventive measure. Cervical screening has reduced cervical cancer in the West but organised screening is unavailable in low-middle income countries where cervical cancer is common. Sociocultural practices promote unsafe sex, such as when minors in these countries acquire HPV infection through marriage to an older infected male or when women/adolescents are war victims. Inebriated party-goers may acquire HPV infection through unsafe sex. HPV vaccines protect against 70% of carcinogenic HPV strains only. Serious adverse effects after vaccination are uncommon. Barrier contraception prevents HPV, and other sexually transmitted diseases. Obesity increases the risk of endometrial cancer. Type-1 endometrial cancer relates to obesity and starts at a younger age, unlike type-2. Obesity also affects fertility. Transgenerational changes in the fetus of the obese gravida can promote obese offspring. Bariatric surgery for obesity is however expensive, with a potential for complications. WHO directives thus advise on prevention of obesity, and the overweight habitus. Primary prevention of obesity through lifestyle changes should start in childhood.

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III, H. W. Jones. Cervical Intraepithelial Neoplasia (Bailliere's Clinical Obstetrics and Gynaecology). Elsevier, 1995.

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Cothran, Mary Mccaa. HUMAN PAPILLOMAVIRUS INFECTION, CIGARETTE SMOKING AND CERVICAL INTRAEPITHELIAL NEOPLASIA. 1996.

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Colposcopy and Treatment of Cervical Intraepithelial Neoplasia, A Beginners' Manual. Intl. Agency for Research on Cancer, 2003.

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Частини книг з теми "CIN (cervical intraepithelial neoplasia)"

Knowlton, Christin A., Michelle Kolton Mackay, Tod W. Speer, Robyn B. Vera, Douglas W. Arthur, David E. Wazer, Rachelle Lanciano, et al. "Cervical Intraepithelial Neoplasia (CIN)." In Encyclopedia of Radiation Oncology, 98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_320.

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Kirschner, Rolf. "CO2-Laser for Treatment Cervical Intraepithelial Neoplasia (CIN) and Human Papilloma Virus (HPV)." In Laser/Optoelektronik in der Medizin / Laser/Optoelectronics in Medicine, 121–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-93435-3_29.

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Soler, Montserrat, Rachel Masch, Rakiya Saidu, and Miriam Cremer. "Thermal Ablation Treatment for Cervical Precancer (Cervical Intraepithelial Neoplasia Grade 2 or Higher [CIN2+])." In Methods in Molecular Biology, 867–82. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1811-0_46.

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Hilgarth, M. "Correlation of Colposcopic, Cytologic, and Histological Findings in Cases of Cervical Intraepithelial Neoplasia (CIN) and Invasive Cervical Carcinoma and the Importance of Colposcopy in Cancer Control." In Colposcopy in Diagnosis and Treatment of Preneoplastic Lesions, 54–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-72761-0_13.

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Hilgarth, M., H. G. Hillemanns, and A. Göppinger. "Therapy of Cervical Intraepithelial Neoplasia." In Colposcopy in Diagnosis and Treatment of Preneoplastic Lesions, 61–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-72761-0_15.

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Schneider, A., C. Köhler, V. Chiantera, and G. F. Vercellino. "Cervical Cancer and Intraepithelial Neoplasia." In Monographs in Virology, 38–49. Basel: S. KARGER AG, 2012. http://dx.doi.org/10.1159/000335313.

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Ferenczy, Alex, and Barbara Winkler. "Cervical Intraepithelial Neoplasia and Condyloma." In Blaustein’s Pathology of the Female Genital Tract, 177–217. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4757-1942-0_7.

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Rosenblatt, Alberto, and Homero Gustavo de Campos Guidi. "Human Papillomavirus and Cervical Intraepithelial Neoplasia." In Human Papillomavirus, 149–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-70974-9_8.

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Coppleson, M. "Pretreatment Evaluation of Patients with Cervical Intraepithelial Neoplasia." In Gynecology and Obstetrics, 442–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70559-5_151.

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Crisp, W. E. "Cryosurgery in the Management of Cervical Intraepithelial Neoplasia." In Gynecology and Obstetrics, 457. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70559-5_158.

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Тези доповідей конференцій з теми "CIN (cervical intraepithelial neoplasia)"

Carbinatto, Fernanda M., Natália M. Inada, Welington Lombardi, Eduardo V. da Silva, Renata Belotto, Cristina Kurachi, and Vanderlei S. Bagnato. "Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade." In SPIE BiOS, edited by Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, et al. SPIE, 2016. http://dx.doi.org/10.1117/12.2213339.

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Sagae, S. "EP393 Liquid nitrogen cryotherapy (N2Cryo) for cervical intraepithelial neoplasia (CIN)." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.452.

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Pu, Yang, Jaidip Jagtap, Asima Pradhan, and R. R. Alfano. "Dysplastic Cervical Intraepithelial Neoplasia (CIN) Tissues Detection using Spatial Frequency Analysis." In Frontiers in Optics. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/fio.2013.jw3a.24.

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Carbinatto, Fernanda M., Natalia M. Inada, Thereza C. Fortunato, Welington Lombardi, Eduardo V. da Silva, José D. Vollet Filho, Cristina Kurachi, Sebastião Pratavieira, and Vanderlei S. Bagnato. "Evaluation of PpIX formation in Cervical Intraepithelial Neoplasia I (CIN) using widefield fluorescence images." In SPIE BiOS, edited by David Levitz, Aydogan Ozcan, and David Erickson. SPIE, 2016. http://dx.doi.org/10.1117/12.2213250.

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Sathija, P. K., S. Rajaram, V. K. Arora, B. Gupta, and N. Goel. "Evaluation of biomarkers p16ink4a/ki-67 in cervical cytology for diagnosis of cervical intraepithelial neoplasia." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685267.

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Background: Novel biomarkers, P16INK4a/Ki-67 are disease specific and identify risk of progression to cervical cancer. Aim: To test the clinical utility of biomarkers p16INK4a/Ki-67 in cervical intraepithelial neoplasia. Methodology: Experimental study was conducted over an 18 month period at a tertiary care hospital. 3500 sexually active women between 30-55 years were screened by VIA/VILI, Pap test & HPV-DNA PCR. All screen positive women (n=280) underwent colposcopy and biopsy if required. At the time of colposcopy repeat cervical smear were taken for evaluation of p16INK4a/Ki-67. Immunocytochemistry for p16INK4A and Ki-67 was done by partitioning one slide into two parts for each biomarker. For p16INK4A positivity, nuclear +/- cytoplasmic scoring and intensity score was calculated and final score obtained. For Ki-67 staining was exclusively nuclear. Staining patterns were categorized as negative, intermediate or strongly positive. Results: 86 women with abnormal cytology were evaluated with p16INK4A/Ki-67 immunocytochemistry and 20.9% (n=18) and 18.6% (n=16) were positive for each biomarker. For ASCUS (n=42) and LSIL (n=23) smears, specificity and NPV were 100% with a likelihood ratio (LR+) of 27 and 25 respectively suggesting good diagnostic accuracy. The combined sensitivity and specificity of p16INK4a/Ki-67 in detecting CIN-2+ lesion was 76.9% and 95.8% respectively with LR+ of 18.72 in high grade smears. Conclusions: p16INK4A/Ki-67 evaluation in cervical cytology are valuable biomarkers in ruling out or detecting CIN2+ in ASCUS and LSIL smears. Unnecessary intervention in large number of low grade smears can be avoided by applying these biomarkers. In high grade smears detection rate of biomarkers p16INK4A/Ki-67 was high and had a good diagnostic accuracy.

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Miranda, Gisele Helena Barboni, Edson Garcia Soares, Junior Barrera, and Joaquim Cezar Felipe. "Method to support diagnosis of cervical intraepithelial neoplasia (CIN) based on structural analysis of histological images." In 2012 25th IEEE International Symposium on Computer-Based Medical Systems (CBMS). IEEE, 2012. http://dx.doi.org/10.1109/cbms.2012.6266297.

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Reich, O., and S. Regauer. "Differentiated Cervical Intraepithelial Neoplasia (d-CIN) represents a rare HPV-independent precursor lesion of squamous cell cancer." In 64. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1757010.

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Aupayagoson, Chanyut. "An automatic segmentation of cervical intraepithelial neoplasia (CIN3) from parabasal cells." In 2014 11th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology (ECTI-CON). IEEE, 2014. http://dx.doi.org/10.1109/ecticon.2014.6839788.

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Lee, Sang-Won, Ji-Young Yoo, Jin-Ho Kang, Moon-Sik Kang, Soon-Hee Jung, YoSep Chong, Dong-Soo Cha, Kyung-Hee Han, Han-Young Choi, and Beop-Min Kim. "Diagnosis of Cervical Intraepithelial Neoplasm (CIN) Using Polarization-Sensitive Optical Coherence Tomography." In 2007 Conference on Lasers and Electro-Optics - Pacific Rim. IEEE, 2007. http://dx.doi.org/10.1109/cleopr.2007.4391525.

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Kawase, Rieko, Toshiyuki Ishiwata, Yoko Matsuda, Munehiko Onda, Kiyoshi Teduka, Kiyoko Kawahara, Toshiyuki Takeshita, and Zenya Naito. "Abstract 286: Expression and role of fibroblast growth factor receptor2 IIIc in human uterine cervical intraepithelial neoplasia (CIN) and invasive cervical cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-286.

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Звіти організацій з теми "CIN (cervical intraepithelial neoplasia)"

van de Sande, Anna, Malika Kengsakul, Margot Koeneman, Marta Jozwiak, Cornelis Gerestein, Arnold-Jan Kruse, Edith van Esch, et al. Imiquimod in cervical dysplasia: a review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0046.

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Review question / Objective: To determine the efficacy of topical imiquimod in treatment of high-grade CIN (defined as regression CIN 1 or less), and to determine the clearance rate of high-risk human papillomavirus (hr-HPV), compared to surgical treatment and placebo. Condition being studied: Women with an untreated, histologically proven, CIN2-3 lesion or women who were persistent high-risk HPV positive. Eligibility criteria: Studies that evaluated the efficacy of imiquimod treatment in intraepithelial lesions or malignancy of other organs, and studies published as conference abstract, narrative review, editorial, letter, or short communication were excluded.

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Veleva, Galabitza, Asen Nikolov, Suzana Nashar, Konstantsa Neykova, and Maria Yunakova. Perinatal Morbidity and Other Severe Adverse Pregnancy Outcomes Associated with Treatment of Cervical Intraepithelial Neoplasia. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, March 2019. http://dx.doi.org/10.7546/crabs.2019.03.16.

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