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Статті в журналах з теми "Ciment injectable"
Rajeh, Mohammad Al, Philippe Liverneaux, Juan José Hidalgo Diaz, Sybille Facca, Anne-sophie Matheron, Stéphanie Gouzou, and Nicolas Maire. "Traitements des enchondromes à la main avec un ciment phosphocalcique injectable : à propos de 8 cas." Hand Surgery and Rehabilitation 35, no. 6 (December 2016): 465. http://dx.doi.org/10.1016/j.hansur.2016.10.124.
Повний текст джерелаДисертації з теми "Ciment injectable"
Goncalves, Stéphane. "Élaboration d'un ciment phosphocalcique injectable : études physico-chimique, galénique et de biocompatibilité." Toulouse, INPT, 2001. http://www.theses.fr/2001INPT008G.
Повний текст джерелаZhang, Jingtao. "Fabrication et propriétés mécaniques de ciments phosphocalciques poreux pour la substitution osseuse." Nantes, 2012. http://archive.bu.univ-nantes.fr/pollux/show.action?id=72eab03b-1c05-4922-af95-e80c6b8c2bdd.
Повний текст джерелаThis study deals with the relations between microstructure and mechanical properties of calcium phosphate cements (CPC) based on -tricalcium phosphate (-TCP) for bone substitution. CPC with various microstructures were prepared and their mechanical properties were investigated and modelled as a function of porosity. Unreacted -TCP particles were detected in the microstructure, exhibiting a weak and microcracked interface with the surrounding apatite matrix, which provokes a decrease in Young's modulus. The coarser the microstructure, the larger the critical flaw size causing fracture. In the case of macroporous materials, the critical flaw size increases with macroporosity, probably due to subcritical crack growth and pore linking during both compressive and flexural loading. Besides, a high liquid-to-powder ratio during processing reduces the strengh reliability (Weibull modulus) of microporous CPC, due to entrapped air bubbles of variable size, acting as random critical flaws. The strength reliability of macroporous CPC is less sensitive to processing, since they are made using a calibrated porogen, and hence have a more deterministic microstructure. Finally, composite CPC were developed using different cellulose ethers, and their handling and mechanical properties were studied. Cellulose ethers significantly improve injectability, cohesion, fracture toughness and tolerance to damage. Si-HPMC hydrogel was also tried as a foaming agent to produce macroporous CPC ; they exhibit and interesting microstructure and promising properties. The knowledge gained should allow to control the microstructure and to find a better compromise between mechanical and biological behaviors
Barou, Carole. "Conception d'un ciment à base de phosphates de calcium pour la reconstruction osseuse et la libération de médicaments." Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. http://www.theses.fr/2022ENCM0019.
Повний текст джерелаThe treatment of bone is a challenge due to the difficulty that has the bone to repair itself. Several surgical situations sometimes require the application of auto- and allografts. Autologous bone grafting is the gold-standard treatment for bone reconstruction as it is the only that can provide osteoinductive growth factors, osteogenic cells and osteoconductive scaffold. These procedures present many limitations including donor site morbidity, increased operative time and providing insufficient quantity or quality. There is therefore a need to develop novel therapeutic strategies able to exploit the natural regenerative potential of bone and that can be delivered in a less invasive manner. Among the materials studied for the development of novel scaffolds, calcium phosphate cements provide many advantages due to its biological performances, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. The aim of this thesis is the development and characterization of novel calcium phosphate based cements for bone regeneration. Our goal is to develop new original processes for the development of injectable scaffolds. The major advantage of such structures lies in the perfect biocompatibility with the mechanical properties similar to those of bone
Jacquart, Sylvaine. "Substitut osseux injectable, antibactérien et résorbable : études physico-chimiques et biologiques d'un ciment composite à base d'apatite." Thesis, Toulouse, INPT, 2013. http://www.theses.fr/2013INPT0079/document.
Повний текст джерелаThe present work concerns research and development of a material for bone substitution, enabling implantation through a mini-invasive surgery, limiting post-operative infections and whose resorbability is adapted to bone regeneration kinetics. This study focused on a calcium carbonate and phosphate based cement, whose setting reaction leads to the formation of a nanocrystalline apatite, similar to bone mineral. First, the setting kinetics and the reaction products were characterised using different techniques, especially X-ray diffraction and FTIR and solid-state NMR spectroscopies. A silver salt – Ag3PO4 or AgNO3, chosen for their antibacterial properties – was then introduced in the formulation. Its effect on the setting reaction kinetics was revealed by data processing of FTIR and NMR spectra and an original reaction mechanism which involves silver and nitrates in the formation of apatite was proposed. The addition of a polysaccharide, carboxymethylcellulose (CMC), in the solid phase of the cement showed a clear improvement of the injectability of the paste, preventing the occurrence of filter-pressing phenomenon, often limiting the injectability of mineral cements. The resistance to compressive strength and elastic modulus of the composite cement were also improved together with a decrease in their porosity. Different in vitro studies were carried out in the presence of cells or bacteria and demonstrated the cytocompatibility of different cement compositions and their antibacterial properties starting at a certain silver concentration, respectively. In vivo implantation of selected compositions showed promising results concerning resorbability of a composite CaCO3 - CaP/CMC/Ag cement and the associated bone neoformation
Mellier, Charlotte. "Synthèse et caractérisation de biomatériaux phosphocalciques multiphasés dopés ou non avec des inhibiteurs de la résorption osseuse." Nantes, 2011. http://archive.bu.univ-nantes.fr/pollux/show.action?id=84f43f72-1aa0-4495-83ff-45ede0bb40e5.
Повний текст джерелаBone grafts substitutes are an alternative to autologous bone grafting procedure. Calcium phosphates cements are good candidates as they are biocompatible, osteoconductive, resorbable and injectable. However, their use is limited to healthy bone sites in small non-load bearing cavities. The first part of this thesis aims the development of a combined medical device for the local release of gallium, an osteoclastic inhibitor, in order to reinforce locally osteoporotic bone. This study is based on synthesis and characterization of calcium phosphate, CDA and ß-TCP, doped with gallium. It has been shown that the incorporation of gallium changes the structure of these materials. Then these calcium phoshates have been incorporated into a typical composition of cement and the influence of gallium on physico-chemical, mechanical and biological properties of this cement has been studied. The second part of this thesis deals with the improvement of textural and mechanical properties of two calcium phosphate cements, named TPN and TPC, by adding an organic component : blood. For both cements, the blood has led to the formation of a cohesive, moldable and sticky paste. The porosity and both mechanical and rheological properties of both cements were altered differently by blood addition. These combined systems (with gallium or blood) could address the limitations usually encountered in the use of calcium phosphate cements
Gonçalves, Luís Pedro Valente. "Ready to use injectable bone substitutes." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17462.
Повний текст джерелаIn recent years, the development and innovation of new bone substitutes has revolutionized the lives of millions of patients. The aim of this work is the development and characterization of a bioactive, injectable and ready-to-use system (also called putty or premixed cement) for bone regeneration. The solid phase is constituted by beta-tricalcium phosphate (β-TCP), FastOs® bioglass (FastOs® BG) and monocalcium phosphate monohydrate (MCPM) powders, while the liquid phase comprises glycerol (G). The synthesis of β-TCP powder was obtained by precipitation reactions followed by heat-treatment; FastOs® BG was obtained by melt-quenching. The characterization of the obtained powders was made through X-ray diffraction (XRD) and measurement of the mean particle sizes and particle size distribution. The putty was prepared by mixing the solid and liquid phases and placed in syringes with a screw cap. Regarding clinical application, injectability, setting time (ST) and mechanical strength were investigated to characterize the putty. Structural analyses of the putty were also performed by XRD, Fourier Tranform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The putty has a solid/liquid weight ratio (S/L) of 3.3, mean ST of ~25 min, ~96% of injectability and a maximum compressive strength of 6 MPa. Therefore, the putty exhibited excellent injectability results, absence of filter pressing effect and acceptable mechanical properties. The structural analysis of the hardened cements revealed the formation of monetite crystals covered by an amorphous apatitic layer after immersion in PBS and water. The results are encouraging and support the conclusion that ready-to-use injectable bone substitutes have excellent handling properties to be used clinically. In accordance with the Directive 93/42/EEC the putty is considered a class III medical device. In order to pave the way towards its commercial release and in order to meet the essential requirements set out in Annex I of the Directive 93/42/EEC, a clinical evaluation has been carried out.
Nos últimos anos, o desenvolvimento e a inovação de novos substitutos ósseos tem revolucionado a vida de milhões de doentes. O objetivo deste trabalho é o desenvolvimento e caracterização de um sistema bioativo, injectável e pronto-a-usar (putty) para regeneração óssea. A fase sólida é constituída por pós de fosfato tricálcico beta (β-TCP), biovidro FastOs (FastOs®BG) e fosfato monocálcico monohidratado (MCPM), enquanto a fase líquida é o glicerol (G). A síntese dos pós de β-TCP foi obtida por reações de precipitação seguida de tratamento térmico; os pós de FastOs®BG foram obtidos por fusão e arrefecimento em água fria (fritagem) (melt-quenching). A caracterização dos pós foi feita por difracção de raios-X (XRD) e medição dos tamanhos de partícula. O sistema injectável pronto-a-usar foi preparado através da mistura das fases sólida e líquida e colocado em seringas seladas com tampa roscada. Do ponto de vista de aplicação clínica, o sistema foi caracterizado tendo em conta a sua injectabilidade, tempo de presa (setting time, ST) e resistência mecânica. A análise estrutural do sistema também foi realizada, através de XRD, espectroscopia de infravermelho com transformada de Fourier (FTIR) e microscopia eletrónica de varrimento (SEM). O sistema injectável pronto-a-usar tem uma razão em peso sólido/líquido (S/L) de 3,3, um ST médio de ~25 min, ~96% de injectabilidade, e 6 MPa de resistência máxima à compressão. Deste modo, o sistema injetável demonstrou excelentes resultados de injectabilidade, tendo-se verificado ainda a ausência do efeito de filter pressing e propriedades mecânicas aceitáveis. A análise estrutural dos cimentos endurecidos revelou a formação de cristais de monetite recobertos por uma camada apatítica amorfa após imersão em PBS e em água. Os resultados obtidos são promissores e permitem concluir que o sistema injetável pronto-a-usar possui excelentes propriedades de manipulação do ponto de vista clínico. De acordo com a Directiva 93/42/CEE o sistema injetável é considerado um dispositivo médico de classe III. Com o objectivo de contribuir para o seu processo de lançamento comercial e seguindo os requisitos essenciais estabelecidos no anexo I da Directiva 93/42/CEE foi elaborado um relatório tendo em conta a avaliação clínica do sistema injectável.
Le, Renard Pol-Edern. "Formulations pour le traitement local de tumeurs solides par hyperthermie à médiation magnétique." Phd thesis, 2011. http://tel.archives-ouvertes.fr/tel-00580668.
Повний текст джерелаТези доповідей конференцій з теми "Ciment injectable"
Shah, Nisarg, and David J. Mooney. "Abstract B043: Enhanced T-cell immunity in vivo using injectable bioengineered scaffolds." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-b043.
Повний текст джерелаSasikala, Arathyram Ramachandra Kururp, Afeesh Rajan Unnithan, Chan Hee Park, and Cheol Sang Kim. "Abstract B041: An injectable magnetic nanogel system for filling surgical residual cavity with effective cancer immunotherapy combined hyperthermic capability." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-b041.
Повний текст джерела