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Статті в журналах з теми "CIDR1a"
1
Villalva, Alina. "Histórias de famílias de palavras: o caso de 'laranja' e 'cidra'." LaborHistórico 6, no. 3 (2020): 245–75. http://dx.doi.org/10.24206/lh.v6i3.35389.
Повний текст джерелаАнотація:
Laranja é um caso na história do léxico do Português por razões várias, nomeadamente conceptuais, etimológicas, semânticas e gramaticais. As razões conceptuais estão relacionadas com a dificuldade em saber exatamente se o nome que é dado ao fruto corresponde sempre ao mesmo fruto e se o fruto a que se dá o nome de laranja teve sempre esse nome, ou se outros nomes lhe estiveram ou estão ainda atribuídos. As razões etimológicas ligam-se à ausência de um elo na cadeia que liga o étimo remoto (Sânscrito nɑ̄raṅgɑ́h̥) à forma laranja, mesmo admitindo que a forma Árabe nɑ̄rɑ́nŷɑ assumiu um papel veicular. Quanto às razões semânticas, importa compreender o processo de polissemia que fixa laranja como nome de um projétil usado sobretudo em brincadeiras de Carnaval e como termo de cor. Acresce, por último, a necessidade de considerar a complexidade gramatical de laranja, que pode ser um nome feminino, um nome masculino ou um adjetivo, sem nunca mudar de forma.A resolução deste caso implica uma investigação em várias frentes, nomeadamente históricas, factuais e linguísticas, e sincrónicas, mas neste trabalho, dados os limites físicos, ficarão de fora os últimos cem anos. Esta investigação diz respeito à forma laranja e aos seus derivados (especialmente laranjeira, laranjal e laranjada), mas também a cidra e derivados (como cidrão, cidrada, cidreira e cidral), porque as duas se entrecruzam inevitavelmente. No final, espera-se chegar a uma narrativa coerente que conte a história destas famílias de palavras.
2
Oosthuizen, Nicky, Kristina Porter, Samir Burato та ін. "286 Effects of Presynchronization with Prostaglandin F2α and a Progestin, and Delayed Insemination on Pregnancy Rates with Sexed Semen in Replacement Beef Heifers". Journal of Animal Science 100, Supplement_3 (2022): 136. http://dx.doi.org/10.1093/jas/skac247.252.
Повний текст джерелаАнотація:
Abstract To determine effects of presynchronization and delayed fixed-time artificial insemination (TAI) on pregnancy rates (PR/AI) with sexed semen, 1,844 beef heifers were enrolled in a completely randomized design at 12 locations. Within location, heifers were randomly assigned to one of five treatments: 1 and 2), heifers administered prostaglandin F2α (PGF) on day -7, gonadotropin-releasing hormone (GnRH) and a CIDR insert on day 0, PGF at CIDR removal on day 7, and another injection of GnRH at TAI 72 hours later with conventional (CTRL72-CNV) or sexed semen (CTRL72-SEX); 3 and 4), treated the same as CTRL72 but received a CIDR insert on day -7 at PGF administration and TAI at 60 hours with conventional (CIDR60-CNV) or sexed semen (CIDR60-SEX); 5), treated the same as CIDR60 but had TAI delayed to 72 hours with sexed semen (CIDR72-SEX). Estrus expression between day 7 and TAI did not differ (P=0.92) between CIDR60 and CIDR72 heifers but was greater (P< 0.001) in CIDR60 and CIDR72 heifers compared with CTRL72 heifers. Among treatments, PR/AI differed (P< 0.001) and were greater (P≤0.003) in CTRL72-CNV and CIDR60-CNV heifers than CIDR60-SEX and CIDR72-SEX heifers. Furthermore, PR/AI were greater (P< 0.001) in CTRL72-SEX and CIDR60-SEX heifers when compared with CIDR72-SEX heifers but only tended (P=0.09) to differ between CTRL72-SEX and CIDR60-CNV heifers. No differences (P=0.33) were determined between CTRL72-CNV and CIDR60-CNV or between CTRL72-SEX and CIDR60-SEX heifers (P=0.22). In conclusion, no differences were determined between heifers presynchronized with only PGF and those presynchronized with PGF and a CIDR insert when inseminated with either conventional or sexed semen. Therefore, use of a CIDR insert for an additional 7 days was not beneficial to PR/AI when heifers were TAI at 60 hours with either conventional or sexed semen. Additionally, delaying TAI to 72 hours with sexed semen after presynchronization with both PGF and a CIDR insert has a negative impact on PR/AI.
3
Lusingu, John P. A., Anja T. R. Jensen, Lasse S. Vestergaard, et al. "Levels of Plasma Immunoglobulin G with Specificity against the Cysteine-Rich Interdomain Regions of a Semiconserved Plasmodium falciparum Erythrocyte Membrane Protein 1, VAR4, Predict Protection against Malarial Anemia and Febrile Episodes." Infection and Immunity 74, no. 5 (2006): 2867–75. http://dx.doi.org/10.1128/iai.74.5.2867-2875.2006.
Повний текст джерелаАнотація:
ABSTRACT Antibodies to variant surface antigen have been implicated as mediators of malaria immunity in studies measuring immunoglobulin G (IgG) binding to infected erythrocytes. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important target for these antibodies, but no study has directly linked the presence of PfEMP1 antibodies in children to protection. We measured plasma IgG levels to the cysteine-rich interdomain region 1α (CIDR1α) of VAR4 (VAR4-CIDR1α), a member of a semiconserved PfEMP1 subfamily, by enzyme-linked immunosorbent assay in 561 Tanzanian individuals, who were monitored clinically for 7 months. The participants resided in Mkokola (a high-transmission village where malaria is holoendemic) or Kwamasimba (a moderate-transmission village). For comparison, plasma IgG levels to two merozoite surface protein 1 (MSP1) constructs, MSP1-19 and MSP1 block 2, and a control CIDR1 domain were measured. VAR4-CIDR1α antibodies were acquired at an earlier age in Mkokola than in Kwamasimba, but after the age of 10 years the levels were comparable in the two villages. After controlling for age and other covariates, the risk of having anemia at enrollment was reduced in VAR4-CIDR1α responders for Mkokola (adjusted odds ratio [AOR], 0.49; 95% confidence interval [CI], 0.29 to 0.88; P = 0.016) and Kwamasimba (AOR, 0.33; 95% CI, 0.16 to 0.68; P = 0.003) villages. The risk of developing malaria fever was reduced among individuals with a measurable VAR4-CIDR1α response from Mkokola village (AOR, 0.51; 95% CI, 0.29 to 0.89; P = 0.018) but not in Kwamasimba. Antibody levels to the MSP1 constructs and the control CIDR1α domain were not associated with morbidity protection. These data strengthen the concept of developing vaccines based on PfEMP1.
4
Oosthuizen, Nicola, Pedro Fontes та Cliff Lamb. "130 Presynchronization with Prostaglandin F2αand prolonged exposure to exogenous progesterone impacts estrus expression and alters fertility in beef heifers". Journal of Animal Science 98, Supplement_2 (2020): 19–20. http://dx.doi.org/10.1093/jas/skz397.043.
Повний текст джерелаАнотація:
Abstract To determine the effects of 2 presynchronization strategies in conjunction with delayed fixed-time artificial insemination (TAI) on pregnancy rates to TAI (PR/AI), 1,700 Angus beef heifers at 3 locations were enrolled in a completely randomized design with a 2×2 factorial arrangement of treatments. Within location, all heifers were randomly assigned to 1 of 4 treatments: 1) PG54 (n = 434), heifers received a 25-mg injection of prostaglandin F2α (PGF) 7 d prior (d -14) to the initiation of the 7-d CO-Synch + CIDR protocol wherein they received a 100-µg injection of gonadotropin-releasing hormone (GnRH) and a CIDR insert on d -7, a 25-mg injection of PGF at CIDR removal on d 0, and a second injection of GnRH concurrently with TAI 54±2 h later; 2) PG72 (n = 426), heifers were exposed to the same treatment as PG54; however, TAI was performed 72 ± 2 h after CIDR removal; 3) PG-CIDR54 (n = 422), same as PG54 but heifers received a CIDR insert on d -14 in addition to PGF; 4) PG-CIDR72 (n = 418), same as PG-CIDR54; however, TAI was performed 72±2 h after CIDR removal. Estrus detection patches were applied to all heifers on d 0 and were evaluated for activation at TAI. Pregnancy was diagnosed between 30 and 47 d after TAI. The percentage of heifers exhibiting estrus between d 0 and TAI was greater (P < 0.001) in the PG72, PG-CIDR54, and PG-CIDR72 treatments compared to the PG54 treatment (78.11, 86.59, and 91.09 vs. 31.05%, respectively). Furthermore, estrus response was greater (P < 0.001) in PG-CIDR72 heifers when compared to PG72. Pregnancy rates to TAI differed among treatments and were greater (P < 0.05) in the PG72 and PG-CIDR54 treatments when compared to PG-CIDR72 (48.8 and 50.4 vs. 38.4%, respectively), and were greater (P = 0.034) in PG-CIDR54 vs. PG54 (43.1%). Moreover, a tendency (P = 0.097) was determined on PR/AI between PG54 and PG72. In conclusion, presynchronization strategies and prolonged exposure to exogenous progesterone have the potential to alter estrus expression and improve fertility in replacement beef heifers.
5
Oosthuizen, Nicola, Pedro Fontes та Cliff Lamb. "129 Presynchronization with Prostaglandin F2αand prolonged exposure to exogenous progesterone impacts estrus expression and alters fertility in beef heifers". Journal of Animal Science 98, Supplement_2 (2020): 41. http://dx.doi.org/10.1093/jas/skz397.094.
Повний текст джерелаАнотація:
Abstract To determine the effects of 2 presynchronization strategies in conjunction with delayed fixed-time artificial insemination (TAI) on pregnancy rates to TAI (PR/AI), 1,700 Angus beef heifers at 3 locations were enrolled in a completely randomized design with a 2×2 factorial arrangement of treatments. Within location, all heifers were randomly assigned to 1 of 4 treatments: 1) PG54 (n = 434), heifers received a 25-mg injection of prostaglandin F2α (PGF) 7 d prior (d -14) to the initiation of the 7-d CO-Synch + CIDR protocol wherein they received a 100-µg injection of gonadotropin-releasing hormone (GnRH) and a CIDR insert on d -7, a 25-mg injection of PGF at CIDR removal on d 0, and a second injection of GnRH concurrently with TAI 54±2 h later; 2) PG72 (n = 426), heifers were exposed to the same treatment as PG54; however, TAI was performed 72 ± 2 h after CIDR removal; 3) PG-CIDR54 (n = 422), same as PG54 but heifers received a CIDR insert on d -14 in addition to PGF; 4) PG-CIDR72 (n = 418), same as PG-CIDR54; however, TAI was performed 72±2 h after CIDR removal. Estrus detection patches were applied to all heifers on d 0 and were evaluated for activation at TAI. Pregnancy was diagnosed between 30 and 47 d after TAI. The percentage of heifers exhibiting estrus between d 0 and TAI was greater (P < 0.001) in the PG72, PG-CIDR54, and PG-CIDR72 treatments compared to the PG54 treatment (78.11, 86.59, and 91.09 vs. 31.05%, respectively). Furthermore, estrus response was greater (P < 0.001) in PG-CIDR72 heifers when compared to PG72. Pregnancy rates to TAI differed among treatments and were greater (P < 0.05) in the PG72 and PG-CIDR54 treatments when compared to PG-CIDR72 (48.8 and 50.4 vs. 38.4%, respectively), and were greater (P = 0.034) in PG-CIDR54 vs. PG54 (43.1%). Moreover, a tendency (P = 0.097) was determined on PR/AI between PG54 and PG72. In conclusion, presynchronization strategies and prolonged exposure to exogenous progesterone have the potential to alter estrus expression and improve fertility in replacement beef heifers.
6
Moussiliou, A., L. Turner, G. Cottrell, et al. "Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants." Journal of Infectious Diseases 221, no. 12 (2020): 2010–17. http://dx.doi.org/10.1093/infdis/jiaa043.
Повний текст джерелаАнотація:
Abstract Background Plasmodium falciparum-infected erythrocytes bind to specific endothelial cell receptors via members of the PfEMP1 family exported onto the erythrocyte surface. These interactions are mediated by different types of cysteine-rich interdomain region (CIDR) domains found in the N-terminal region of all PfEMP1. CIDRα1 domains bind endothelial protein C receptor (EPCR), CIDRα2–6 domains bind CD36, whereas the receptor specificity of CIDRβ/γ/δ domains is unknown. Methods In this study, we investigated the level of immunoglobulin (Ig)G targeting the different types of PfEMP1 CIDR during the first year of life. We used plasma collected longitudinally from children of pregnant women who had been followed closely through pregnancy. Results Antibodies to CIDRα1 domains were more frequent in cord blood compared with antibodies to CIDRα2–6 domains. Higher IgG levels to EPCR-binding CIDRα1 variants positively correlated with the timing of first infections. Antibodies to all PfEMP1 types declined at similar rates to the point of disappearance over the first 6 months of life. At 12 months, children had acquired antibody to all types of CIDR domains, mostly in children with documented P falciparum infections. Conclusions These observations agree with the notion that the timing and phenotype of first P falciparum infections in life are influenced by the immune status of the mother.
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Reyes, Raphael, Louise Turner, Isaac Ssewanyana, et al. "Probing the naturally acquired immune response to malaria for broadly reactive antibodies targeting P. falciparum antigens linked with severe disease." Journal of Immunology 206, no. 1_Supplement (2021): 59.13. http://dx.doi.org/10.4049/jimmunol.206.supp.59.13.
Повний текст джерелаАнотація:
Abstract Severe malaria is caused by the adhesion of Plasmodium falciparum-infected erythrocytes to host receptors on vascular endothelium. Specifically, binding of the parasite variant surface antigen domain CIDRa1 to host endothelial protein C receptor (EPCR) is strongly associated with severe disease. In malaria-endemic regions, children quickly develop immunity against severe malaria, indicative of the development of an effective immune response against CIDRa1 domains. Indeed, serum IgG from naturally immune individuals exhibited reactivity against a diverse panel of CIDRa1 variants. In an effort to analyze CIDRa1 antibody responses at a monoclonal level, we isolated CIDRa1-specific memory B cells from malaria-experienced individuals living in Uganda and expressed the corresponding monoclonal antibodies (mAbs). Our approach has yielded anti-CIDRa1 mAbs ranging in breadth from variant-specific to reactive with the full spectrum of CIDRa1 domain variants, irrespective of their extensive sequence diversity. The broadest antibodies can be separated into two categories, those that bind outside the EPCR binding site and display exceptional breadth with modest inhibition of EPCR binding and those that target the EPCR binding site and show potent EPCR-binding inhibition. Two EPCR-binding site-targeting mAbs isolated from two different donors showed signs of convergent evolution. Our results demonstrate that natural P. falciparum infection can induce a broad and inhibitory antibody response against CIDRa1. Current experiments are aimed at understanding the structural basis of antibody-mediated inhibition of CIDRa1-EPCR binding to inform the design of a vaccine that protects against severe malaria.
8
Filho, Ramiro Oliveira, Rafael R. Paiva, Gabriela Dalmaso de Melo, et al. "PSV-3 Ovarian dynamics of brahman cows submitted to five-day or twelve-day progesterone-based estrus synchronization protocol." Journal of Animal Science 99, Supplement_3 (2021): 310–11. http://dx.doi.org/10.1093/jas/skab235.570.
Повний текст джерелаАнотація:
Abstract The aim of this study was to investigate the ovarian response of Brahman cows submitted to two different estrus synchronization protocols and to determine the estrus response and ovulation time. A total of 153 Brahman cows were randomly assigned to receive one of the following estrus synchronization protocols: 1) CIDR insert and an injection of prostaglandin F2α (25 mg, PGF) on Day -5 and CIDR removal with PGF on Day 0 (CIDR5; n = 77); 2) CIDR insert on Day -12 and an injection of PGF on Day -12, Day -5 and Day 0 upon CIDR removal (CIDR12; n = 76). Estrotect breeding indicator patches were placed on Day 0 and cows were artificially inseminated (AI) 12h after estrus detection; cows not detected in estrus after 96h received TAI coupled with 100 µg of GnRH. Ovarian dynamics were observed during the protocol and follicular diameter were measured every 12h after AI until ovulation. Cows synchronized with CIDR12 had increased follicular diameter (CIDR5, 10.19 ± 0.51 vs. CIDR12, 13.12 ± 0.52 mm; P = 0.01) and decreased serum concentrations of progesterone (CIDR5, 1.68 ± 0.12 vs. CIDR12, 0.81 ± 0.12 ng/ml; P < 0.01) at CIDR removal. The percentage of cows exhibiting estrus did not differ between treatments (CIDR5, 66.2 vs. CIDR12, 64.5%; P = 0.25). No difference was observed in ovulation rate (CIDR5, 94.1 vs. CIDR12, 94.1%; P = 0.6). Time of estrus expression and ovulation time after CIDR removal did not differ (CIDR5, 59.9 ± 2.3 vs. CIDR12, 61.5 ± 2.3h; P = 0.71 and CIDR5, 88.1 ± 2.6 vs. CIDR12, 90.9 ± 2.6h; P = 0.75; respectively). In conclusion, extended length of CIDR with additional PGF increased follicular diameter and decreased concentrations of progesterone but did not influence estrus response and ovulation time in Brahman cows.
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Lipińska-Zubrycka, Lidia, Maciej Grochowski, Jürg Bähler, and Michał Małecki. "Pervasive mRNA uridylation in fission yeast is catalysed by both Cid1 and Cid16 terminal uridyltransferases." PLOS ONE 18, no. 5 (2023): e0285576. http://dx.doi.org/10.1371/journal.pone.0285576.
Повний текст джерелаАнотація:
Messenger RNA uridylation is pervasive and conserved among eukaryotes, but the consequences of this modification for mRNA fate are still under debate. Utilising a simple model organism to study uridylation may facilitate efforts to understand the cellular function of this process. Here we demonstrate that uridylation can be detected using simple bioinformatics approach. We utilise it to unravel widespread transcript uridylation in fission yeast and demonstrate the contribution of both Cid1 and Cid16, the only two annotated terminal uridyltransferases (TUT-ases) in this yeast. To detect uridylation in transcriptome data, we used a RNA-sequencing (RNA-seq) library preparation protocol involving initial linker ligation to fragmented RNA—an approach borrowed from small RNA sequencing that was commonly used in older RNA-seq protocols. We next explored the data to detect uridylation marks. Our analysis show that uridylation in yeast is pervasive, similarly to the one in multicellular organisms. Importantly, our results confirm the role of the cytoplasmic uridyltransferase Cid1 as the primary uridylation catalyst. However, we also observed an auxiliary role of the second uridyltransferase, Cid16. Thus both fission yeast uridyltransferases are involved in mRNA uridylation. Intriguingly, we found no physiological phenotype of the single and double deletion mutants of cid1 and cid16 and only minimal impact of uridylation on steady-state mRNA levels. Our work establishes fission yeast as a potent model to study uridylation in a simple eukaryote, and we demonstrate that it is possible to detect uridylation marks in RNA-seq data without the need for specific methodologies.
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Sulistyaningsih, Erma, Yunita Armiyanti та Rosita Dewi. "THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME". MNJ (Malang Neurology Journal) 7, № 1 (2021): 34–39. http://dx.doi.org/10.21776/ub.mnj.2021.007.01.8.
Повний текст джерелаАнотація:
Background: Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is an important protein responsible for the pathogenesis of severe malaria, including cerebral malaria. The protein is highly diverse. The CIDR1α-PfEMP1 binds endothelial protein receptor (EPCR) and may associated with the brain swelling in childhood malaria. Objective: To analyze the CIDR1α-PfEMP1 from Indonesian isolate and determine its association with cerebral malaria outcome. Methods: Fifteen blood samples of clinically mild to severe malaria-patient were collected for DNA extraction. Malaria diagnosis was conducted microscopically by Giemsa-stained thin blood smear. The CIDR1α domain was amplified by PCR using specific primer and PCR product was sequenced. The nucleotide sequences were analyzed by NCBI blast, DNASIS MAX 3 and translated into amino acid sequences using Expasy Translation Tool. Results: One out of fifteen samples was severe malaria case and infected with P. falciparum, the rest were clinically mild to moderate malaria and infected with pure P. falciparum or mixed infection of P. falciparum and P. vivax. Amplification for CIDR1α domain resulted a single band of + 550 bp from a severe sample only. Sequencing of PCR product on both strands read 524 nucleotides and BLAST analysis confirmed as CIDR1α sequence. Multiple alignment showed 74-78% nucleotide sequence similarity with reference sequences, but amino acid sequences presented 23.5% homologous. Conclusion: An identified CIDR1α domain only from severe case implicating the potential association with the severe outcome including cerebral malaria, but the highly diverse of the domain needs further studies on the interaction with the pathological-causing receptor in the host.