Дисертації з теми "Chronic obstructive pulmonary diseases (COPD)"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "Chronic obstructive pulmonary diseases (COPD)".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Noell, Guillaume. "Multi-Level Integrated Analysis of Chronic Obstructive Pulmonary Disease (COPD) heterogeneity." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667980.
Повний текст джерелаBaldrick, Francina Rose. "Diet and chronic obstructive pulmonary disease (COPD)." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527657.
Повний текст джерелаJohn, Michelle. "The extra-pulmonary effects of chronic obstructive pulmonary disease (COPD)." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14405/.
Повний текст джерелаAlhaddad, Maath. "Cardiopulmonary manifestations in chronic obstructive pulmonary disease (COPD)." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30008/.
Повний текст джерелаMcAllister, David Anthony. "Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5615.
Повний текст джерелаUbhi, Baljit Kaur. "A metabolomic study of chronic obstructive pulmonary disease (COPD) and its phenotypes." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608237.
Повний текст джерелаMcPherson, E. A. "Equine chronic obstructive pulmonary disease (COPD) : publications 1974-1985." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/28607.
Повний текст джерелаJones, Sharon Scardina. "Evaluating a Discharge Bundle for Chronic Obstructive Pulmonary Disease." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4861.
Повний текст джерелаHaddad, Donna L. "Nutritional status indicators in hospitalized patients with chronic obstructive pulmonary disease (COPD)." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=67536.
Повний текст джерелаBaril, Jacinthe. "Interaction between circulatory and respiratory exercise adaptation in chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF)." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97901.
Повний текст джерелаWadell, Karin. "Physical training in patients with chronic obstructive pulmonary disease - COPD." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-363.
Повний текст джерелаBodduluri, Sandeep. "Analysis of chronic obstructive pulmonary disease (COPD) using CT images." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/2441.
Повний текст джерелаLewis, A. "Chronic Obstructive Pulmonary Disease (COPD) : patient experiences of COPD and pulmonary rehabilitation : an applied phenomenological study." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/349087/.
Повний текст джерелаHallin, Runa. "Nutritional Depletion in Chronic Obstructive Pulmonary Disease (COPD) : Effect on Morbidity, Mortality and Physical Capacity." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9512.
Повний текст джерелаLethbridge, Mark William. "The role of T cells in chronic obstructive pulmonary disease (COPD)." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407475.
Повний текст джерелаJohnson, Lorna Claire. "Respiratory and peripheral muscle with severe chronic obstructive pulmonary disease (COPD)." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420413.
Повний текст джерелаMcGorum, Bruce C. "Studies on the aetiopathogenesis of equine chronic obstructive pulmonary disease (COPD)." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/30476.
Повний текст джерелаCollins, Peter Francis. "Nutritional screening and nutritional support in chronic obstructive pulmonary disease (COPD)." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/379646/.
Повний текст джерелаRavi, Arjun Kumar. "Macrophages, monocytes and interleukin-6 in chronic obstructive pulmonary disease." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/macrophages-monocytes-and-interleukin6-in-chronic-obstructive-pulmonary-disease(806db259-02de-4d50-8c2e-5b57cb2425c0).html.
Повний текст джерелаBhunthurat, Anurak. "The Vitamin B-6 Status of Patients with Chronic Obstructive Pulmonary Disease." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc500541/.
Повний текст джерелаPakhale, Smita. "Development and Validation of the new McGill COPD Quality of Life Questionnaire." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95663.
Повний текст джерелаIntroduction: Il y a nécessité d'avoir accès à un questionnaire de qualité de vie qui pourrait offrir les avantages d'un questionnaire générique et ceux d'un questionnaire spécifique à la MPOC. Objectif: Finaliser l'élaboration d'un nouveau questionnaire hybride le 'McGill COPD Quality of Life Questionnaire' (éléments spécifiques à la maladie complémentés d'éléments génériques issus du SF-36) et évaluer ses propriétés psychométriques (fiabilité, validité, réponse au changement) chez les sujets atteint d'une MPOC. [...]
Reavell, Colleen Frances. "Resolution of muscle wasting during an acute exacerbation of chronic obstructive pulmonary disease (COPD)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0031/MQ64435.pdf.
Повний текст джерелаArnardóttir, Ragnheiður Harpa. "Physical Training and Testing in Patients with Chronic Obstructive Pulmonary Disease (COPD)." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7632.
Повний текст джерелаThe overall aims of the studies were to investigate the effects of different training modalities on exercise capacity and health-related quality of life (HRQoL) in patients with moderate or severe COPD and, further, to explore two of the physical tests used in pulmonary rehabilitation.
In study I, the 12-minute walking distance (12MWD) did not increase on retesting in patients with exercise-induced hypoxemia (EIH) whereas 12MWD increased significantly on retesting in the non-EIH patients. In study II, we found that the incremental shuttle walking test was as good a predictor of peak exercise capacity (W peak) as peak oxygen uptake (VO2 peak) is. In study III, we investigated the effects of two different combination training programmes when training twice a week for eight weeks. One programme was mainly based on endurance training (group A) and the other on resistance training and callisthenics (group B). W peak and 12MWD increased in group A but not in group B. HRQoL, anxiety and depression were unchanged in both groups. Ratings of perceived exertion at rest were significantly lower in group A than in group B after training and during 12 months of follow-up. Twelve months post-training, 12MWD was back to baseline in group A, but significantly shorter than at baseline in group B. Thus, a short endurance training intervention delayed decline in 12MWD for at least one year. Patients with moderate and severe COPD responded to training in the same way. In study IV, both interval and continuous endurance training increased W peak, VO2 peak, peak exhaled carbon dioxide (VCO2 peak) and 12MWD. Likewise, HRQoL, dyspnoea during activities of daily life, anxiety and depression improved similarly in both groups. At a fixed, submaximal workload (isotime), the interval training reduced oxygen cost and ventilatory demand significantly more than the continuous training did.
Arnardóttir, Ragnheiður Harpa. "Physical training and testing in patients with chronic obstructive pulmonary disease (COPD) /." Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7632.
Повний текст джерелаForslund, Linus, and Emil Sjödin. "Experiences of living with Chronic Obstructive Pulmonary Disease (COPD) : A literature review." Thesis, Umeå universitet, Institutionen för omvårdnad, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161652.
Повний текст джерелаBrandén, Eva. "Chronic infection with Chlamydia pneumoniae in COPD and lung cancer." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-344-2/.
Повний текст джерелаSuh, Sooyeon. "STRESS, ANXIETY, AND HEART RATE VARIABILITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275495558.
Повний текст джерелаKren, Erin McGuire. "Physical Activity and Veteran Status in Obesity and Chronic Obstructive Pulmonary Disease." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4931.
Повний текст джерелаRittmaster, Dana. "Anthropometric, clinical and lifestyle determinants of exercise energy expenditure in patients with chronic obstructive pulmonary disease (COPD)." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82412.
Повний текст джерелаDe, Souza Melissa. "Central circulatory adaptations to low and high intensity cycling in patients with chronic obstructive pulmonary disease (COPD)." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84021.
Повний текст джерелаFarooqi, Nighat. "Nutrition and energy expenditure in women with chronic obstructive pulmonary disease." Doctoral thesis, Umeå universitet, Lungmedicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128680.
Повний текст джерелаBakgrund/Syfte Kroniskt obstruktiv lungsjukdom (KOL) är en av de stora folksjukdomarna där dödligheten ökar mest globalt sett. I Sverige är ökningen av KOL mest uttalad för kvinnor. Viktminskning är vanligt vid KOL. Låg kroppsvikt, låg andel fettfrimassa och lågt kroppsmasseindex (BMI) är dessutom riskfaktorer för ökad sjuklighet och dödlighet. Det finns därför behov av att ge anpassad kostbehandling for att motverka viktnedgång eller för att uppnå viktuppgång. För framgångsrik kostbehandlingen behövs metoder som på ett tillförlitligt sätt kan bedöma den totala energiförbrukningen, energiintag, och energibehov., Dessa metoder har ännu inte utvärderats väl hos KOL patienter. Det övergripande syftet därför med denna avhandling var att validera och öka kunskaperna om metoder som är tillförlitliga för att kunna bedöma energiförbrukning, energiintag och energibehov hos patienter med KOL. Vidare, jämfördes BMI och kliniska egenskaper mellan personer med och utan KOL in en populations-baserad studie. Metoder Viloenergiförbrukning mättes med indirekt kalorimeter hos kvinnor med KOL. Den totala energiförbrukningen mättes hos dessa kvinnor med dubbelmärktvatten metoden (DLW) (Arbete 1-3) under en 14-dagars period. Samtidigt bedömdes energiförbrukningen med två aktivitetesmätare, SenseWear Armband, mjukvaruversion 5.1 och 6.1 (SWA5 respektive SWA6), och ActiHeart (arbete 1). Energiintaget bedömdes med kostanamnes och 7-dagars matdagbok (arbete 2); energibehovet beräknades med olika viloenergiförbruknings formler och fysisk aktivitetsnivå uppskattad med en stegräknare (arbete 3). En sammanställning och en analys genomfördes av energibehovet baserad på data från flera studier som har mätt TEE med DLW hos KOL patienter (Arbete 4). BMI och kliniska egenskaper jämfördes mellan personer med och utan KOL i ett stort populationsbaserat material från Obstruktiv Lungsjukdom i Norrbotten (OLIN) studien (Arbete 5). Resultat Det fanns en stor variation in viloenergiförbrukningen och energiförbrukning mätt med DLW hos kvinnor med KOL. Energiförbrukningen mätt med aktivitetsmätare SWA5 visade hög tillförlitlighet både på grupp- och individnivå, medan SWA6 och ActiHeart metoderna underskattade energiförbrukningen. Energiintaget bedömd med kostanamnes och 7-dagars matdagbok visade en underskattning med 28% respektive 20% jämfört med DLW metoden. Det rapporterade energiintaget stämde för flertalet kvinnor bättre mot DLW metoden när energiintaget bedömdes med 7-dagars matdagbok jämfört med kostanamnes (63% mot 32%). Det beräknade energibehovet från stegräknare och från fem av sex olika RMR ekvationer låg inom en rimlig marginal (± 10%) jämfört med den uppmätta energiförbrukningen med DLW. Beräkning av energibehov baserat på tillgänglig data om energiförbrukning mätt med DLW varierade utifrån kroppsvikt och fettfrimassa hos patienter med KOL. Kvinnor hade en lägre viloenergiförbrukning och energiförbrukning per kg kroppsvikt och dag, och högre daglig viloenergiförbrukning och energiförbrukning per kg fettfrimassa och dag jämfört med män. I den populationsbaserade studien hade personer med KOL signifikant lägre BMI och högre prevalens av undervikt än personer utan KOL. Det fanns ett oberoende samband mellan KOL och lågt BMI. Färre personer med KOL var överviktiga än personer som inte hade KOL. Kvinnor med KOL hade både lägre BMI och högre andel med undervikt än män med KOL. Slutsats SenseWear Armband med programvaran 5.1 visar sig kunna beräkna den totala energiförbrukningen på ett tillförlitligt sätt hos kvinnor med KOL. Energiintaget beräknat utifrån kostanamnes och 7-dagars matdagbok underskattades. Energibehovet kan beräknas med en rimlig precision med hjälp av stegräknare och viloenergiförbrukningsformler hos dessa kvinnor. De sammanställda data om energiförbrukning mätt med DLW kan användas för att beräkna energibehov per kg- kroppsvikt och fettfri massa hos patienter med KOL i kliniskt syfte. I det populationsbaserade materialet från OLIN-studien noterades ett lägre BMI och högre prevalens av undervikt hos personer med KOL, och detsamma resultat förekom hos kvinnor med KOL jämfört med män med KOL.
Higham, Andrew James. "The role of the liver X receptor in chronic obstructive pulmonary disease." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-the-liver-x-receptor-in-chronic-obstructive-pulmonary-disease(b1916ddb-6514-4407-b657-0dede8d7fa28).html.
Повний текст джерелаJantarakupt, Peeranuch. "The experience of men who were managing symptoms of COPD." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/5814.
Повний текст джерелаThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2005" Includes bibliographical references.
Akiki, Zeina. "Biological Markers For Chronic Obstructive Pulmonary Disease And Asthma." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS081/document.
Повний текст джерелаStudying the biological markers in chronic obstructive pulmonary disease (COPD) and asthma, two chronic respiratory diseases affecting millions of individuals around the world, could improve their diagnosis, their treatment and their prevention.This thesis includes two parts. The first aimed to assess the association between a lung-specific biomarker, serum Surfactant Protein D (SP-D), and COPD, and to find cut-off points able to discriminate COPD patients from controls using SP-D levels. It was performed in a case-control study in Lebanon including COPD (n=90) and asthma patients (n=124) and controls (n=180). The second part aimed to assess the cross-sectional and longitudinal associations in adults for systemic inflammatory biomarkers (high sensitivity C reactive protein hs-CRP (n=252) and cytokines (n=283) as well as biomarkers of damage due to oxidative stress (8-Isoprostanes 8-IsoPs (n=258) from the exhaled breath condensate) and asthma outcomes.It was performed in the French longitudinal epidemiological study on the genetics and environmental factors of asthma (EGEA).Results showed that serum SP-D levels were positively associated with COPD and thresholds for SP-D levels in these patients were identified with excellent discriminant values. In EGEA, no association was found between serum hs-CRP levels and asthma control. Serum cytokine profiles (identified by principal component analysis) with high levels of interleukin (IL)-1Ra and IL-10 were associated with less asthma attacks and lower risk of poor asthma control in adults seven years later. The results of the preliminary analyses on the associations between the levels of 8-IsoPs and asthma outcomes are also presented.Overall, these results have shown the usefulness of studying the biological markers related to COPD and asthma
Machado, Stacey Jerrick. "Reducing 30-Day Readmission Rates in Chronic Obstructive Pulmonary Disease Patients." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6609.
Повний текст джерелаMantoani, Leandro Cruz. "Role of physical activity in daily life in Chronic Obstructive Pulmonary Disease (COPD)." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31402.
Повний текст джерелаShaw, I., JM Loots, L. Lategan, and BS Shaw. "Effectiveness of aerobic exercise training in improving pulmonary function in asthmatics." African Journal for Physical, Health Education, Recreation and Dance, 2009. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001698.
Повний текст джерелаHodson, Matthew. "Development of a patient reported experience measure in chronic obstructive pulmonary disease (COPD)." Thesis, University of Portsmouth, 2014. https://researchportal.port.ac.uk/portal/en/theses/development-of-a-patient-reported-experience-measure-in-chronic-obstructive-pulmonary-disease-copd(c7bf6540-155f-4245-b764-daa61ea6f73a).html.
Повний текст джерелаBrozyna, Sheree. "The role of chemokines and chemokine receptors in chronic obstructive pulmonary disease (COPD) /." Title page and abstract only, 2005. http://web4.library.adelaide.edu.au/theses/09SB/09sbb8859.pdf.
Повний текст джерелаKumar, Manish [Verfasser]. "Senescence, DNA damage and repair in chronic obstructive pulmonary disease (COPD) / Manish Kumar." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068772697/34.
Повний текст джерелаLytras, Theodoros 1987. "The Role of occupational exposures in Chronic Obstructive Pulmonary Disease." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/586017.
Повний текст джерелаIntroducció: Les exposicions ocupacionals es consideren un dels factors de risc importants per a la malaltia pulmonar obstructiva crònica (MPOC) juntament amb tabaquisme. No obstant això, l'evidència prové principalment d'estudis de mida petita i transversals i preguntes importants segueixen sense resposta, per exemple quines exposicions específiques són responsables, la magnitud del risc involucrat i com el risc varia entre homes i dones o entre fumadors i no fumadors. L'objectiu d'aquesta tesi és examinar l'associació entre exposicions ocupacionals objectivament avaluades i els canvis en els resultats relacionats amb la MPOC durant dues dècades en l'Enquesta de Salut Respiratòria de la Comunitat Europea (ECRHS), un gran estudi longitudinal multicèntric poblacional. Mètodes: La mostra de la població general amb edats compreses entre 20 i 44 anys es va seleccionar aleatòriament a l’ECRHS entre 1991 i 1993, i a els participants se’ls hi va fer seguiment dues vegades en el transcurs de 20 anys. L'historial complet de treballs durant el període de seguiment es va vincular amb la Matriu d'Ocupació-Exposició ALOHA (+), generant estimacions d'exposicions ocupacionals a 12 categories d'agents. Les espirometries es van realitzar en cada visita d'estudi. Els resultats d'interès van ser: disminució de la funció pulmonar, incidència de bronquitis crònica i incidència de MPOC després de broncodilatació. Resultats: L'exposició a pols, gasos i fums biològics i pesticides es va associar amb una major incidència de MPOC, amb un 21% de tots els casos de MPOC atribuïbles a aquests tres agents. Els pesticides es van associar amb una major incidència d’expectoració crònica, però només en les dones, i gasos i fums i dissolvents també amb expectoració crònica, però només en els homes. L'exposició a la pols mineral es va associar amb una major incidència d’expectoració crònica i l’exposició a metalls amb incidència de bronquitis crònica, en ambdós sexes. Totes les exposicions estudiades, excepte els dissolvents, es van associar amb una disminució accelerada de la relació FEV1 / CVF, (VEMS/CVF) particularment en fumadors homes. Les dones exposades a la pols d'origen biològic també van tenir majors disminucions en la capacitat vital forçada (CVF), igual que els homes exposats als pesticides. Conclusions: Una proporció important dels casos de MPOC és atribuïble a exposicions ocupacionals. L'efecte de l'ocupació en els resultats relacionats amb la MPOC és complex i depèn del tipus d'exposició, el sexe i el tabaquisme. Es requereix més investigació per proporcionar més infromació sobre les associacions observades
Sohanpal, Ratna. "Understanding the reasons for non-participation in self-management interventions amongst patients with chronic conditions : addressing and increasing opportunities for patients with advanced chronic obstructive pulmonary disease to access self-management." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/15031.
Повний текст джерелаStone, Ian. "Effects of COPD and its treatment on cardiovascular structure and function assessed through advanced imaging techniques." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/23199.
Повний текст джерелаRamis, Cabrer Daniel 1993. "From chronic obstructive pulmonary disease to lung cancer : an immunologic approach." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/667310.
Повний текст джерелаIt is well established that a subset of cancer patients debuts with immune infiltrates, which organize into aggregates in the tumor niche and its vicinity. These lymphoid structures develop in response to inflammatory stimuli through a tightly regulated process. Besides the prognostic value of TLSs, they also may represent a novel avenue for therapeutic strategies, but it is currently still in its early stages. In contrast with the immune activator role of TLSs, in certain cancers, its effect may point towards tumor progression as a consequence of highly tumor-mediated immunosuppressive conditions present in the tumor niche. Preliminary data provided by the current investigation suggests that a differential immune profile may be present between LC patients and LC patients underlying COPD. This fact could present a potential impact in the prognosis and therapy of these patients. Moreover, crucial markers targeting different signaling pathways involved with oxidative stress, apoptosis, and autophagy were found to be overexpressed in response to immunomodulators administration in the current thesis. These data puts into manifest the interest of additional immunity-related mechanisms that could be targeted in order to assist immunity against cancer.
Chatila, Wissam M. F. "MicroRNA Expression in Regulatory T Cells in Chronic Obstructive Pulmonary Disease." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/333572.
Повний текст джерелаPh.D.
COPD is characterized by an abnormal regulatory T cell (Treg) response with a shift towards a Th1 and Th17 cell responses. However, it is unclear if the function of Treg cells is impaired by smoking and in COPD. In addition, the miRNA profile of Treg cells in COPD is unknown and whether miRNA deregulation contributes to COPD immunopathogenesis. We set the objective to study Treg cell function isolated from peripheral blood of patients with COPD versus controls and to compare their miRNA profiles. We also were interested in exploring the function of some of the differentially expressed Treg cell miRNAs. We assessed the Treg cell function by observing their suppressive activity on autologous effector T cells and analyzed their miRNA expression initially by microarray analysis then conducted real time RT-PCR validation for selected miRNAs. In Silico target gene analysis for the validated miRNAs suggested that miR-199-5p is particularly relevant to Treg cell physiology so its function was investigated further using CCD-986Sk and MOLT-4 cells. We found no difference in Treg cell function between COPD and controls but we were able to identify 6 and 96 miRNAs that were differentially expressed in COPD versus control Treg cells. We confirmed that miR-199a-5p was repressed by approximately 4 fold in Treg cells of COPD patients compared to cells in healthy smokers. Importantly, miR-199a-5p had significant overrepresentation of its target genes in the Treg cell transcriptome, with many targets associated with the TGF-b activation pathway. We also confirmed the function of miR-199a5p in an in-vitro loss-of-function cell model running TaqMan® arrays of the Human TGF-b Pathway. These findings suggest that the abnormal repression of miR-199a-5p in patients with COPD compared to unaffected smokers may be involved in modulating the adaptive immune balance in favor of a Th1 and Th17 response.
Temple University--Theses
Tatari, Wisam. "Using Pharmacist-Led Tele-Consultation to Review Patients with Chronic Obstructive Pulmonary Disease." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17311.
Повний текст джерелаPang, Yu. "Human Anti-Histone 3.3 Antibodies as Potential Biotherapeutics for Chronic Obstructive Pulmonary Disease (COPD)." Master's thesis, Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/378762.
Повний текст джерелаM.S.
Chronic Obstructive Pulmonary Disease (COPD), which is characterized by limitation of pulmonary air flow, is now the third major cause of death worldwide. Barrero et al. have reported that the elevation of extracellular hyperacetylated histone H3.3 in the lungs of COPD patients is associated with cytotoxicity and disease progression. They found that extracellular hyperacetylated H3.3 was cytotoxic to lung structural cells and resistant to proteasomal degradation, and that mouse antibodies to either the C- or N- termini of H3.3 could partially reverse H3.3 toxicity in vitro. Thus, we hypothesize that human antibodies directed against H3.3 may be effective biotherapeutics useful to control progression of COPD in vivo. The discovery and development of human monoclonal antibodies (mAbs) is a fast growing field of biotherapeutics. In addition to full length mAbs, antibody fragments also have been used in antibody discovery research. We have used phage display technology in this project to discover human anti-H3.3 antibody Fab fragments. This technology utilizes genetically engineered phage particles containing genes encoding diverse Fab fragments displayed on the particles. The “Ylanthia” library from MorphoSys AG, a synthetic fully human Fab antibody phage display library with 1.3 x 1011 independent clones, was panned against purified recombinant human H3.3 immobilized on 96-well plates. Seven H3.3-binding Fab fragments with unique DNA sequences were isolated after four rounds of panning. Following their expression in E.coli and purification, Fab purities and electrophoretic mobilities were evaluated on SDS-PAGE. The concentration-dependent binding activities of all seven Fabs to human H3.3 were tested by ELISA. All seven Fabs were shown by ELISA to bind H3.3 but not histones 2A, 2B or 4. Since H3.3 is localized to the nucleus, western blotting was used to demonstrate that seven Fabs recognize purified, recombinant H3.3 and denatured natural histone(s) from nuclear extracts of human 293T cells. In order to characterize these molecules further, biological activity assays will be done to test their potential to reverse the toxic effects of H3.3 in cell culture. If these Fabs prove active in cell culture, they will be converted to IgGs and tested in animal models as potential biotherapeutics for COPD.
Temple University--Theses
Donaire, Gonzalez David. "Measure and effects of physical activity in patients with Chronic Obstructive Pulmonary Disease (COPD)." Doctoral thesis, Universitat Ramon Llull, 2015. http://hdl.handle.net/10803/347216.
Повний текст джерелаAntecedentes: La Enfermedad Pulmonar Obstructiva Crónica (EPOC) es una de las principales causas de mortalidad y discapacidad a nivel mundial. La actividad física es uno de los pocos factores modificables que desaceleran la evolución de la EPOC. Sin embargo, la dosis y las características de la actividad física responsables de la desaceleración son todavía desconocidas. En consecuencia, los objetivos de esta tesis son avanzar y perfeccionar la metodología e instrumentos para evaluar la actividad física realizada por los enfermos con EPOC, profundizar en el conocimiento sobre las características y patrones de su actividad física y determinar qué características de la actividad física mejoran el pronóstico de los enfermos con EPOC. Métodos: Han participado 177 individuos con EPOC estable seleccionados de 8 hospitales en España (94% hombre, edad media±DE 71±8 años, volumen espiratorio forzado predicho en 1 s 52±16% e índice de masa corporal 29±5 kg·m-2). La actividad física fue medida por un acelerómetro (SenseWear® Pro2 Armband) y por un cuestionario (Yale Physical Activity Survey, YPAS). Las variables sociodemográficas (edad, sexo, estado civil, nivel educativo, nivel socioeconómico, situación laboral y hábito tabáquico) y las variables clínicas (limitación al flujo aereo, hiperinsuflación pulmonar, disnea, intercambio de gases, inflamación sistémica y local, composición corporal, comorbilidades, calidad de la vida y capacidad de ejercicio), se obtuvieron utilizando instrumentos validados y siguiendo las normas internacionales. La información sobre la evolución de la enfermedad (ingresos hospitalarios y mortalidad) se obtuvo de los registros gubernamentales. Resultados: (Objetivo 1) El YPAS es una herramienta válida para la detección precoz de la inactividad de los individuos con EPOC [área bajo la curva ROC (95% IC) = 0.71 (0.63-0.79)]. (Objetivo 2) El 97% de los individuos con EPOC son capaces de realizar episodios de 10 minutos de actividad física moderada-vigorosa. Más del 50% de los individuos con EPOC cumplen con la recomendación de la Organización Mundial de la Salud sobre actividad física para las personas mayores. La cantidad de actividad física, la proporción de ésta realizada en episodios de 10 minutos y la frecuencia de estos episodios disminuyó con el aumento de la gravedad de la EPOC. (Objetivo 3) La cantidad y la intensidad de la actividad física son determinantes independientes de la evolución de la EPOC. El riesgo de hospitalización por EPOC es un 20% menor por cada 1000 pasos adicionales realizados en baja intensidad media. Sin embargo, una mayor cantidad de pasos diarios a una alta intensidad media no influye en el riesgo de hospitalización por EPOC (HR = 1.01; p = 0,919). Conclusiones: El YPAS es una herramienta válida para la detección precoz de los individuos con EPOC físicamente inactivos. Los pacientes con EPOC grave y muy grave realizan menos episodios y cantidad de actividad física, y tienen menor el ratio entre episodios y cantidad que en aquellos en estado leve y moderado. Una mayor cantidad de actividad física de baja intensidad reduce el riesgo de hospitalización por EPOC.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of worldwide mortality and disability. Physical activity is one of the few modifiable factors that decelerate COPD evolution. Nonetheless, the dose and characteristics of physical activity responsible of the deceleration are still unknown. In consequence, the aims of this thesis are to move forward and refine the methodology and instruments to evaluate the physical activity of COPD individuals, go in depth in the knowledge about the characteristics and the pattern of their physical activity, and determine which physical activity characteristics improve the prognosis of COPD patients. Methods: 177 individuals with stable COPD selected from 8 hospitals in Spain have participated (94% male, mean±SD age 71±8 years, forced expiratory volume in 1 s 52±16% predicted and body mass index 29±5 kg·m-2). Physical activity was measured with an accelerometer (SenseWear® Pro2 Armband) and with a questionnaire (Yale Physical Activity Survey, YPAS). The sociodemographic (age, sex, civil status, educational level, socioeconomic status, employment status, and tobacco habit) and clinical variables (airflow limitation, lung hyperinflation, dyspnoea, gas exchange, local and systemic inflammation, body composition, comorbidities, quality of life, and exercise capacity), were obtained using validated tools and following international standards. Information about the evolution of the disease (Hospital Admissions and Mortality) was obtained from government registries. Results: (Objective 1) The YPAS is a valid tool for the detection of COPD individuals’ inactivity [the area under the ROC curve is 0.71 (95% CI: 0.63–0.79)]. (Objective 2) The 97% of COPD individuals are able to perform 10-minutes bouts of moderate-to-vigorous physical activity. More than 50% of the COPD individuals met the World Health Organization recommendation of physical activity for the elderly. The quantity of physical activity, the percentage of activity done in bouts and the frequency of bouts decreased with increasing COPD severity. (Objective 3) The quantity and the intensity of physical activity are independent determinants of the COPD evolution. Every additional 1000 daily steps at low-average intensity reduce by 20% the risk of COPD hospitalisation. However, a greater quantity of daily steps at high-average intensity does not influence the risk of COPD hospitalisation (HR 1.01, p=0.919). Conclusion: The YPAS is a valid instrument for the early screening of COPD patients who run the risk of sedentarism. Patients with severe and very severe COPD perform fewer bouts and less quantity of physical activity, and have lower ratio between bouts and quantity than those in mild and moderate stages. Higher quantity of low-intensity physical activity reduces the risk of COPD hospitalization.
McCafferty, John. "Respiratory heat and moisture loss in health, asthma and chronic obstructive pulmonary disease (COPD)." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29259.
Повний текст джерелаLindberg, Anne. "Chronic obstructive pulmonary disease (COPD) : prevalence, incidence, decline in lung function and risk factors." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-347.
Повний текст джерела