Дисертації з теми "Chronic and acute diseases"
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Stewart, Simon. "Optimising therapeutic efficacy in acute and chronic cardiac disease states /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phs851.pdf.
Повний текст джерелаWhite, David James. "Haemophilus in acute and chronic respiratory disease." Thesis, Liverpool John Moores University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304425.
Повний текст джерелаWei, Jin. "Acute Kidney Injury and Chronic Kidney Disease." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6780.
Повний текст джерелаRota, Cinzia. "Effect of foetal and adult stem cells in acute and chronic kidney diseases." Thesis, Open University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594841.
Повний текст джерела何美美 and Mai-mai Ho. "A study on the acute and chronic effects of morphine on rat stomachs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31230611.
Повний текст джерелаBevan, Damon. "Cytokine involvement in ultraviolet (UV) B induced chronic and acute inflammation in porcine skin." Thesis, Royal Veterinary College (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300963.
Повний текст джерелаPhan, Thanh Huyen. "Development of therapeutic extracellular vesicles for the treatment of acute and chronic lung diseases." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28760.
Повний текст джерелаBrocca, Alessandra. "Characterization of molecular pathways involved in acute and acute-on-chronic liver disease." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425355.
Повний текст джерелаIntroduzione: Lo scompenso acuto in cirrosi è definito come la progressione acuta di una o più gravi complicanze della patologia epatica ed è la principale causa di ospedalizzazione nei pazienti con cirrosi. L'insufficienza epatica acuta su cronica (ACLF) è caratterizzata da uno scompenso acuto della cirrosi, da danno d'organo e da un elevato tasso di mortalità a 28 giorni. L'ACLF è caratterizzato da infiammazione sistemica e l'outcome infausto è strettamente associato con l'eccessiva risposta infiammatoria che si attiva nel paziente. L'inflammasoma è un complesso multi-proteico che attiva, mediante taglio proteolitico, citochine pro-infiammatorie come IL-1β e IL-18. Queste, hanno un ruolo nello sviluppo della patologia epatica. Le vescicole extracellulari (EVs) sono coinvolte in molti processi biologici importanti, sia fisiologici che patologici. Il processo di secrezione delle EVs da diversi tipi di cellule e la loro azione nel modulare l'avanzamento della patogenesi nella malattia epatica, non sono ancora completamente chiariti. Scopo: Lo scopo di questo studio è caratterizzare la via del segnale coinvolta nello scompenso acuto della cirrosi e dell'insufficienza epatica acuta-su-cronica attraverso: la caratterizzazione del profilo infiammatorio dei pazienti arruolati, lo studio in vitro dell'effetto citotossico nel plasma dei pazienti nelle cellule tubulari renali (RTC), lo studio dell'espressione dell'inflammasoma nelle cellule trattate e nelle cellule mononucleate del sangue periferico (PBMC) estratte dai pazienti, la caratterizzazione delle EVs estratte dal plasma dei pazienti arruolati e lo studio del loro effetto in vitro su colture di RTC. Materiali e Metodi: sono stati arruolati pazienti con cirrosi compensata, scompenso acuto in cirrosi, insufficienza epatica acuta-su-cronica e una popolazione di volontari sani come controllo. I livelli plasmatici di IL-6, IL-1β e IL-18 sono stati misurati con kit ELISA. L'effetto citotossico del plasma nelle RTC è stato testato con il kit costituito da annexina V e propidio ioduro. Il livello di espressione delle molecole dell'inflammasoma è stato determinato sia nelle cellule stimolate con il plasma, sia nei PBMC estratti dai pazienti, attraverso Real Time Poly Chain Reaction (RT-PCR). Le EVs plasmatiche sono state estratte mediante ultracentrifugazione e la loro concentrazione determinata con il Nanosight. La loro caratterizzazione è stata eseguita mediante analisi al FACS. L'effetto citotossico delle EVs sulle RTC è stato determinato mediante saggio XTT. Risultati: I livelli plasmatici delle citochine pro-infiammatorie, misurati nei primi pazienti arruolati, non mostra differenze tra i gruppi di pazienti con cirrosi compensata, scompensata e insufficienza epatica acuta-su-cronica. Anche la vitalità e la morte cellulare nelle colture stimolate con i plasma dei pazienti arruolati non hanno mostrato un profilo peculiare dei gruppi testati e non è stata riscontrata attivazione della trascrizione delle molecole dell'inflammasoma. L'espressione del Tool-like receptor 2 (TLR-2) nei PBMC si è dimostrata significativamente elevata nei pazienti con cirrosi compensata rispetto a quelli con scompenso acuto (p=0,036). Aggiungendo albumina al mezzo di coltura cellulare si è notata una riduzione dell'effetto citotossico del plasma dei pazienti nelle RTC. La concentrazione plasmatica di EVs risulta maggiore nei pazienti con insufficienza epatica acuta-su-cronica rispetto ai controlli sani. Le vescicole non esprimono i marcatori tipici piastrinici (CD41 e CD42b) e monocitari (CD14) sulla loro superficie ma esprimono il marcatore dell'epitelio attivato da piastrine (CD62E). I livelli di CD62E sono significativamente elevati nei pazienti con insufficienza eparica acuta-su-cronica rispetto ai controlli sani e ai pazienti con cirrosi compensata (p=0,0041 e p=0,0111, rispettivamente). I livelli di CD40L sono significativamente elevati in tutti i gruppi di pazienti rispetto ai controlli sani (p<0,02). Le EVs isolate dei pazienti con insufficienza epatica acuta-su-cronica hanno un effetto citotossico superiore rispetto a quelle dei controlli sani e dei pazienti con cirrosi compensata nelle RTC (p<0,0001). Le cellule incubate con le EVs da pazienti con scompenso acuto in cirrosi e insufficienza epatica acuta-su-cronica vanno incontro ad apoptosi (p<0,0001), a produzione massiccia di ROS (p<0,0001), alla perdita della capacità di internalizzare l'albumina (p<0,0001) e alla riduzione dell'espressione di Zonula Occludens-1 (ZO-1) (p=0,0166) rispetto ai soggetti sani e ai pazienti con cirrosi compensata. Non si osserva invece un cambiamento nell'espressione cellulare di megalina e PGC1α. Conclusioni: Il ruolo delle EVs nella cirrosi scompensata necessita di essere approfondito perché potrebbero rappresentare il veicolo su cui viaggiano i mediatori del danno d’organo extraepatico.
Lo, Iek-long, and 羅奕龍. "Impacts of cognitive impairment on acute exacerbations of chronic obstructive pulmonary disease among Chinese elderly patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45830770.
Повний текст джерелаChen, Roy Yu-Wei. "Biomarkers for acute exacerbation of chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57759.
Повний текст джерелаMedicine, Faculty of
Medicine, Department of
Experimental Medicine, Division of
Graduate
Harbord, Marcus William Nixon. "Investigation of acute inflammation in Crohn's disease and chronic granulomatous disease." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399572.
Повний текст джерелаReavell, Colleen Frances. "Resolution of muscle wasting during an acute exacerbation of chronic obstructive pulmonary disease (COPD)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0031/MQ64435.pdf.
Повний текст джерелаChin, Elizabeth D. "Symptom Experience and Treatment Delay during Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsn_diss/30.
Повний текст джерелаWong, May Yue Wai. "Novel anti-fibrotic agents in acute and chronic kidney disease." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22015.
Повний текст джерелаSabapathy, Surendran, and n/a. "Acute and Chronic Adaptations To Intermittent and Continuous Exercise in Chronic Obstructive Pulmonary Disease Patients." Griffith University. School of Physiotherapy and Exercise Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070115.170236.
Повний текст джерелаSabapathy, Surendran. "Acute and Chronic Adaptations To Intermittent and Continuous Exercise in Chronic Obstructive Pulmonary Disease Patients." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/366117.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Physiotherapy and Exercise Science
Full Text
McVeigh, Beverley. "An acute care program for patients with chronic obstructive pulmonary disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ62030.pdf.
Повний текст джерелаFlaherty, Helen M. "Informal Caregivers’ Experience During Acute Exacerbation of COPD in Older Adults: A Dissertation." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsn_diss/51.
Повний текст джерелаSaudny-Unterberger, Helga. "Impact of nutritional support on changes in functional status during an acute exacerbation of chronic obstructive pulmonary disease (COPD)." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23294.
Повний текст джерелаForced vital capacity (FVC % predicted) improved significantly over the study period in treated vs control subjects (+11.10 $ pm$ 4.63 vs $-$4.50 $ pm$ 2.14; p = 0.026). Nitrogen balances were calculated for 9 subjects, and all were in negative balance ($-$8.42 $ pm$ 1.74 g nitrogen/d) with no difference between groups.
Because of the high doses of methylprednisolone administered (69.6 $ pm$ 8.3 mg/d), and their known catabolic effects, we examined whether the dose affected nitrogen balance and muscle strength. Both nitrogen balance (r = $-$0.73; p = 0.025) and grip strength (r = $-$0.76; p $<$ 0.001) worsened with higher doses of steroids. The catabolic process may have resulted from elevated energy requirements, inadequate intake of protein and energy or been induced by high doses of steroids.
Hospitalized COPD patients are highly stressed and catabolic, and the means to preventing protein wasting during an acute exacerbation of their disease remains to be established. (Abstract shortened by UMI.)
Butt, Muhammad U. "AGGRESSIVE DIURESIS AND SEVERITY-ADJUSTED LENGTH OF HOSPITAL STAY IN ACUTE CONGESTIVE HEART FAILURE PATIENTS." UKnowledge, 2018. https://uknowledge.uky.edu/crd_etds/2.
Повний текст джерелаJackson, Kim Geraldine. "Acute and chronic effects of monounsaturated fatty acid intake on chylomicron metabolism." Thesis, University of Surrey, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360952.
Повний текст джерелаRogers, Andrew Vincent. "Inflammatory cell distribution in human bronchial mucosa : influence of chronic and acute disease." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440463.
Повний текст джерелаGallagher, Sean. "Reducing acute kidney injury in patients with chronic kidney disease undergoing cardiac surgery." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8669.
Повний текст джерелаFossati, S. "Acute cardiovascular effects of exposure to airborne particulate matter : a study of possible pathogenetic mechanisms." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/64549.
Повний текст джерелаFisher, Kimberly A. "Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/717.
Повний текст джерелаFisher, Kimberly A. "Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/717.
Повний текст джерелаStell, Ian Michael. "Extending the role of noninvasive ventilation in acute exacerbations of chronic obstructive pulmonary disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406692.
Повний текст джерелаFearn, Amy. "Role of the immune system during the development of acute and chronic renal disease." Thesis, University of Newcastle Upon Tyne, 2013. http://hdl.handle.net/10443/1862.
Повний текст джерелаUniacke, Mark. "The natural history of acute kidney injury and its relationship to chronic kidney disease." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/361330/.
Повний текст джерелаCorten, Lieselotte. "The use of assisted autogenic drainage in children with acute and chronic respiratory disease." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25169.
Повний текст джерелаRudomanova, Valeriia. "Unraveling the Secrets of Kidney Disease: Novel Molecular Mechanisms of Acute and Chronic Kidney Injury." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623250686588821.
Повний текст джерелаBailey, Patricia Hill. "Patients', family caregivers', and nurses' stories of acute exacerbation events of Chronic Obstructive Pulmonary Disease." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21379.
Повний текст джерелаLoschi, Michael. "CD19SFv-CAR regulatory T-cell prevent acute graft versus host disease and improve chronic graft versus host disease." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC265.
Повний текст джерелаAllo-hematopoietic stem cell transplantation is a curative option for many malignant and benign hematologic disorders. However, its beneficial effect is counterbalanced by the development of acute and chronic graft versus host disease (GVHD). The therapeutic options to reduce GVHD incidence and severity mostly rely on pan immunosuppressive drugs that expose the recipient to opportunistic infections and relapse of the original disease. Regulatory T cell (Treg) therapies have proven efficient but are limited by inter product variable suppressive capacities and number of Treg. The chimeric antigen receptor (CAR) engineering now give the opportunity to redirect Tcell and increase their function. Here, we tested CAR 4-1BB Treg targeting the human CD19 (hCD19) to suppress GVHD. In aGVHD we found that CD19SFv-CAR Treg are specifically activated through their CAR. This hyperactivation confers higher metabolic and suppressive capacities. After CAR activation, CD19SFv-CAR Treg display increased homing abilities to the gut which is the main target organ in aGVHD. CD19SFv-CAR Treg preserve the Graft versus leukemia (GvL) response and display anti-tumor activity. In cGVHD CD19SFv-CAR Treg eliminate Germinal center B-cells (GC B-cells) and improve the pulmonary function of the recipients. This study identifies the CAR-hCD19 Treg as a way to improve Treg immunotherapy efficiency by increasing Treg suppressive capacities, homing, and metabolism without altering the GvL response of the graft
Huiart, Laetitia. "Corticosteroid use and the risk of acute myocardial infarction in patients with chronic obstructive pulmonary disease." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19420.
Повний текст джерелаMirza, Mohd Tahir Beg Fatim Tahirah. "Optimising Assessment and Rehabilitation in People Hospitalised with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/76705.
Повний текст джерелаKadri, Amer N., Roop Kaw, Yasser Al-Khadra, Hasan Abumasha, Keyvan Ravakhah, Adrian V. Hernandez, and Wai Hong Wilson Tang. "The role of B-type natriuretic peptide in diagnosing acute decompensated heart failure in chronic kidney disease patients." Termedia Publishing House Ltd, 2018. http://hdl.handle.net/10757/624714.
Повний текст джерелаRevisión por pares
Kirk, Richard James Thompson. "Endothelial function response to different modes of acute and chronic exercise in both health and diseased populations." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:16454.
Повний текст джерелаMoga, Ana Maria. "Acute effect of noninvasive ventilatory support on maxium exercise capacity in patients with chronic obstructive pulmonary disease." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104757.
Повний текст джерелаContexte : La ventilation non invasive (VNI) a été utilisée pendant un test d'exercice. Toutefois, la mesure dans laquelle la VNI améliore la tolérance à l'exercice est très variable. À ce jour, aucune étude n'a examiné l'effet de la VNI sur la capacité d'effort maximale lorsqu'il est appliqué au cours d'un test d'exercice dynamique aérobie maximal. Objectif: Evaluer l'effet aigu de BiPAP (Respironics), comparativement à l'absence d'aide, sur la capacité maximale d'exercice chez les individus atteints de la maladie pulmonaire obstructive chronique (MPOC). Méthodes: Une étude croisée randomisée a été utilisée. Dix patients souffrant de MPCO stable (VEMS1 53 ± % pred.) ont effectué trois preuves d'effort supplémentaire sur une bicyclette ergométrique tout en respirant à travers une bout buccal, soit) sans le soutien de la pression(ØPS), ii) avec un soutien de 0cm H2O (PS0; IPAP & EPAP 4 cm H2O) ou iii), avec un soutien de 10cm H2O (PS10; IPAP 14 & EPAP 4 cm H2O). La fin des tests a été déterminée par les symptômes des patients, et chacun des tests a été effectué pendant un jour différent. Pendant l'exercice, nous avons mesuré la charge de travail(WLmax), la dyspnée et l'effort de la jambe (Borg), le volume pulmonaire en fin d'expiration (EELV), rythme respiratoire, la consommation d'O2 (VO2) et la production de CO2 (VCO2). Résultats: Il n'y avait aucune différence dans la charge de travail maximale du pic entre PS 10(33 ±16) et PS0 (30,5 ±13). Toutefois, la charge de travail maximum du pic était plus faible avec PS0 et PS10 de ØPS. La dyspnée pendant le pic de l'effort a été similaire à ØPS, PS0 et PS10. À isoload, elle était inférieure à ØPS par rapport à PS10 et PS0 (p < 0,01). L'effort de la jambe à l'exercice de pointe était plus élevé à ØPS de PS10 et PS0 (p < 0,05), alors qu'il n'était pas différent au isoload. Le volume courant (VT) et la ventilation minute (VE) étaient les plus élevés avec PS10 et les plus bas à ØPS, à la fois à l'exercice de pointe (p < 0,001) et isoload (p < 0,001). EELV était similaire à l'exercice de pointe avec les trois conditions. VO2 et VCO2 ont été plus grande avec PS10 et PS0 de ØPS (les deux p < 0,001), à la fois à l'exercice de pointe et isoload.Conclusion: L'utilisation du BiPAP pendant l'exercice augmente VT et VE, ce qui cause une augmentation du VO2, VCO2, et la dyspnée, qui à son tour réduit WL à l'exercice maximal chez les patients MPOC.
Van, der Schyff Nasief. "Risk factors for prolonged ventilation in patients with chronic obstructive pulmonary disease presenting with acute respiratory failure." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/12112.
Повний текст джерелаIncludes bibliographical references (leaves 35-37).
Patients with COPD presenting to the Emergency Unit with acute hypercapnic respiratory failure often require invasive mechanical ventilation and subsequent admission to the intensive care unit (ICU). These patients are at an increased risk of prolonged and complicated ventilation and often experience weaning difficulties. In addition, the impact of a previous episode of pulmonary tuberculosis that might have resulted in structural lung disease on the duration of mechanical ventilation in such patients has not previously been evaluated. Methods: All patients with COPD admitted to the Respiratory ICU at Tygerberg academic hospital from the 01st January 2004 until 31st December 2007 requiring intubation and invasive mechanical ventilation for acute hypercapnic respiratory failure were included in the study.
Centi, Justin. "Autonomic dysfunction in Parkinson's Disease: an evaluation of acute and chronic effects of cognition and daily life." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12729.
Повний текст джерелаNon-motor symptoms of Parkinson's disease (PD) have emerged as an important research topic. Autonomic dysfunction is particularly prevalent, with the most common manifestation being orthostatic hypotension (OH). While cognitive deficits have been demonstrated in PD even in the absence of dementia, there has been no investigation of the potential effects of hemodynamic disorders on cognitive performance. The main hypothesis of the present study was that PD patients with OH would be cognitively impaired relative to those without OH, especially when in the upright position. The effects of impaired postural hemodynamics on cognition were examined in 36 nondemented PD patients - 18 diagnosed with OH (PDOH) and 18 without OH (PDNOH) - and 18 healthy normotensive control participants (NC) matched for age, male:female distribution, and education. Neuropsychological measures of executive function, visuospatial performance, memory, and attention/concentration were repeated in supine and upright positions to evaluate chronic and acute hemodynamic effects, respectively. Autonomic measures, taken concurrent to neuropsychological testing, included beat-to-beat arterial pressure, electrocardiography, transcranial Doppler sonography, and respiratory function. The first study assessed cognition associated with a diagnosis of OH. The second examined the relation between changes in blood pressure and cerebral blood flow and the impact of impaired hemodynamics on cognition. The third assessed the relation between subjective autonomic complaints and measurable impairments in autonomies and cognition. As hypothesized, both PDNOH and PDOH were impaired relative to NC, regardless of posture. There were few chronic effects of OH on cognition (PDNOH vs. PDOH, supine) whereas PDOH were significantly more impaired than PDNOH when upright (acute effect). Cerebral blood flow was reduced in PDOH compared to PDNOH and NC, and this reduction was correlated with performance on cognitive tests. PDOH had more subjective autonomic and functional complaints than PD alone. The presentation of PD with comorbid OH is associated with cognitive impairment, particularly while in the upright position, in patients without dementia. The prevalence of comorbidity of OH in PD is significant. The accompanying cognitive deficiency indicates that OH should be treated as both a physiologically dangerous and neuropsychologically relevant issue in individuals with this disorder.
Olesin, Elizabeth A. "Transcriptional Regulation of Effector and Memory Responses during Acute and Chronic Lymphocytic Choriomeningitis Virus (LCMV) Infection." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/1000.
Повний текст джерелаHindricks, Janka. "Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-182270.
Повний текст джерелаde, la Puente Robles Beatriz. "Role of the sigma-1 receptor in the sensory-discriminative and affective-motivational components of acute and chronic pain." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/360581.
Повний текст джерелаEl dolor es una experiencia sensorial y emocional desagradable. Es un mecanismo muy complejo determinado por dos componentes: el componente sensorial discriminativo, que corresponde a los mecanismos neurofisiológicos de la nocicepción y que informa de las características del dolor (naturaleza, duración, intensidad,…) y el componente afectivo-motivacional, que expresa la connotación desagradable relacionada con la percepción del dolor y que conlleva consecuencias emocionales que afectan al estado de ánimo y al bienestar del individuo. En la presente Tesis Doctoral se estudian estos dos componentes que conforman el dolor, evaluando respuestas de comportamiento en dos modelos animales de dolor, un modelo de dolor agudo visceral y un modelo de dolor crónico de origen neuropático. Además, se estudia el papel del receptor sigma-1 (σ1R) en cada modelo animal de dolor, evaluando su posible implicación tanto en el componente sensorial como en el afectivo. Para ello, se pusieron en práctica dos estrategias experimentales. Por un lado, se utilizaron ratones modificados genéticamente a los que se les ha eliminado el gen del receptor del sigma-1 (ratones knock-out σ1R) y por otro lado, se realizó un tratamiento farmacológico sistémico en ratones salvajes (wild-type) con el E-52862 (S1RA), un antagonista del receptor sigma-1 altamente selectivo. El E-52862 es un compuesto que ha sido desarrollado por ESTEVE y que tras su primera evaluación en seres humanos ha demostrado un buen perfil de seguridad y tolerabilidad (estudios clínicos de Fase I). Actualmente continúa siendo evaluado en subsecuentes estudios clínicos como indicación para el dolor neuropático de diferentes etiologías (estudios de Fase II). Los resultados de esta Tesis Doctoral proporcionan nuevos conocimientos sobre el receptor sigma-1 que apoyan el desarrollo clínico del antagonista selectivo para este receptor, el E-52862, como una opción terapéutica adecuada para el tratamiento del dolor neuropático y las comorbilidades afectivas asociadas a esta patología.
Björklund, Fredrik. "Platelet reactivity and comorbidities in acute coronary syndrome." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51096.
Повний текст джерелаTsai, Ling Ling. "Novel Technologies to Measure Physical Activity and Improve Health Outcomes in People with Chronic Obstructive Pulmonary Disease." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/19974.
Повний текст джерелаDye, Andrew. "The role of Chlamydophila pneumoniae and 60KDa heat shock protein (HSP60) antibodies in acute and chronic respiratory disease." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408823.
Повний текст джерелаSteer, Alan John. "Survival, quality of life and health resource use following hospitalisation for acute exacerbations of chronic obstructive pulmonary disease." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2036.
Повний текст джерелаBourne, Simon Charles. "The effect of smoking on the severity, and mechanisms of acute exacerbations of chronic obstructive pulmonary disease (COPD)." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/67617/.
Повний текст джерелаAllahwala, Usaid. "Anatomical, haemodynamic, biochemical and imaging characteristics of the coronary collateral circulation in acute and chronic atherosclerotic disease processes." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25095.
Повний текст джерелаArmitage, Trudi. "Development of improved diagnostics for acute and persistent Chlamydia trachomatis infections." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16584/.
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