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Дисертації з теми "Cholesterol control"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 20 лютого 2023

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1

Al-Seeni, Madeha N. "Control of hepatic cholesterol esterification." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293154.

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2

Sampson, William James. "The intracellular control of cholesterol metabolism." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26913.

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The liver has a major role in the metabolism of cholesterol, being the main site of lipoprotein assembly and degradation and the only tissue where the metabolism of cholesterol to bile acids occurs. This provides the major pathway for the removal of cholesterol from the body. The results described in this thesis concern the use of specific enzyme inhibitors (58-035, Azacholesterol, Mevinolin) to determine the intracellular use of different sources of cholesterol in monolayers of rat hepatocytes. In particular, the fates of newly synthesized cholesterol from mevalonic acid and cholesterol deriv

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3

Veen, Jelske Nynke van der. "Nuclear receptors in control of cholesterol transport." [S.l. : Groningen : s.n. ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/304675490.

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4

Dunn, Stuart Antony. "Hormone-sensitive lipase and the control of lipid metabolism in the human macrophage foam cell." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311114.

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5

Sims, Helen M. "Transcriptional control of microsomal triglyceride transfer protein gene expression in the hamster." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366470.

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6

Martinic, Goran (Gary), of Western Sydney Hawkesbury University, of Science Technology and Environment College, and School of Environment and Agriculture. "Cyclodextrins as potential human anti-atherosclerotic agents." THESIS_CSTE_EAG_Martinic_G.xml, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for

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7

Witsken, Colleen. "The Effect of Parental Control Over Child-Feeding on Compliance to Dietary Recommendations to Lower Blood Cholesterol." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179758468.

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8

Dun, Alison. "Spatial and temporal control of regulated exocytosis by protein and lipid interactions." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8087.

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Cellular communication requires the transport of chemical messengers between intracellular compartments and from cell to cell. The regulated exocytosis of a secretory vesicle at the plasma membrane involves the merger of two bilayers, with markedly different lipid composition, within a millisecond time scale. The spatial and temporal control of the protein and lipid complement at these fusion sites is essential. A highly conserved family of proteins are known to drive this fusion event; SNAP-25 and syntaxin-1 (t-SNAREs) associate at the plasma membrane in a 1:1 stoichiometry to provide a bindi

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9

Kangas-Kontio, T. (Tiia). "Genetic background of HDL-cholesterol and atherosclerosis:linkage and case-control studies in the Northern Finnish population." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295812.

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Abstract Coronary heart disease (CHD), a manifestation of atherosclerosis, is the leading single cause of death in Finland. CHD is affected by numerous genetic and environmental factors, their combined effects and interactions between them. Low HDL-cholesterol (HDL-C) is an independent risk factor for atherosclerosis and the most common dyslipidemia associated with early onset CHD, but the mechanisms regulating HDL-C levels and protecting from atherosclerosis are still not completely understood. Adiponectin is a hormone that is secreted by adipose tissue and has several anti-atherosclerotic ef

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10

Kranz, Eylath. "Dietary habits and life style in the etiology of cholesterol gallstone disease a matched case control study /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=968492649.

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11

Esche, Curtis A. "The effects of streptozotocin-induced diabetes on control of serum cholesterol levels in female strain A/ST mice." Virtual Press, 1991. http://liblink.bsu.edu/uhtbin/catkey/834628.

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Diabetics often have elevated levels of serum lipids and cholesterol and increased risk of cardiovascular disease. Streptozotocin-induced diabetes was used to determine whether elevated serum cholesterol levels in diabetics are due to loss of control of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the committed step in cholesterol synthesis. Strain A/ST female mice were fed 10% corn oil diets, half with 2% cholesterol. Experimental groups were injected with 9.0 mg streptozotocin / 100g body weight. Diabetes was confirmed by weight loss, elevated blood sugars, and enlar

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12

Huwait, Etimad A. "Liver-X-receptor-mediated expression of key genes in macrophages implicated in the control of cholesterol homeostasis and atherosclerosis." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54714/.

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Atherosclerosis is a leading cause of morbidity and mortality in the western world. The deposition of lipoprotein cholesterol in the arterial wall is a critical early step in the pathogenesis of atherosclerosis. These atherogenic lipoproteins are then taken up by macrophages to transform into lipid-loaded foam cells. ATP-binding cassette transporter-Ai (ABCAi) is a membrane-bound protein that mediates efflux of cholesterol from cells, such as macrophages. Tangier disease, which arises due to mutations in the ABCAi gene, is associated with foam cells in a number of tissues and premature atheros

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13

Akenhead, Michael L. "The Influence of Cholesterol-Related Membrane Fluidity on the Shear Stress Control of Neutrophil Adhesion and Its Implications in Hypercholesterolemia." UKnowledge, 2016. http://uknowledge.uky.edu/cbme_etds/41.

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Hypercholesterolemia is a significant risk factor in the development of cardiovascular disease and is associated with chronic leukocyte adhesion in the microvasculature. While the underlying mechanisms behind this have yet to be determined, it may be possible that hypercholesterolemia impairs the fluid shear stress (FSS) inactivation of neutrophils through the rigidifying effect of cholesterol on membrane fluidity. FSS restricts surface expression of CD18 integrins through cathepsin B (ctsB) proteolysis, which minimizes neutrophil adhesivity. If hypercholesterolemia blocks FSS mechanotransduct

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14

Timby, Niklas. "Effects of feeding term infants low energy low protein formula supplemented with bovine milk fat globule membranes." Doctoral thesis, Umeå universitet, Pediatrik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88192.

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Background Observational studies have shown that early nutrition influences short- and long-term health of infants. Formula-fed infants have higher protein and energy intakes and lower intakes of several biologically active components present in human milk. Some of these are present in the milk fat globule membrane (MFGM). The aim of the present study was to examine the effects of feeding term infants an experimental low energy low protein formula supplemented with bovine milk fat globule membranes. Our hypothesis was that infants fed experimental formula (EF), compared to infants fed standard

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15

Martinic, Gary. "Cyclodextrins as potential human anti-atherosclerotic agents." Thesis, View thesis View thesis, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Анотація:

Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for

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16

Brand, Céline. "Une nouvelle cible de TGF(bêta)1 dans le contrôle de la stéroidogenèse corticosurrénalienne : StAR (protéine régulatrice du transport intramitochondrial du cholestérol)." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10137.

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La famille des facteurs de croissance transformant (tgf) est constituee d'une trentaine de peptides dimeriques qui controlent la croissance et la differenciation de nombreux types cellulaires. Tgf1 est un regulateur autocrine de la steroidogenese qui inhibe l'expression de la steroide 17-hydroxylase (p-450c17). Au cours de ce travail, j'ai identifie une nouvelle cible de tgf1 dans la voie de biosynthese des hormones corticosteroides : star (steroidogenic acute regulatory protein), une proteine mitochondriale indispensable au transfert du cholesterol de la membrane externe a la membrane interne

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17

Zheng, Hui. "Apolipoprotein A-I lipidation in primary mouse hepatocytes: Separate controls for phospholipid and cholesterol transfers." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/27101.

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The liver is the site for both apolipoprotein A-I (apoA-I) synthesis and ATP-binding cassette transporter A1 (ABCA1) expression. To investigate the function of hepatic lipidation of apoA-I by cholesterol and phospholipid, and delineate the role of hepatic ABCA1 in these lipidation pathways, I have expressed human apoA-I by adenovector-mediated gene transfer into primary mouse hepatocytes. Kinetic studies demonstrate that newly synthesized apoA-I acquires both cholesterol and phospholipid during secretion and at the cell surface. Approximately 80% of the phospholipidation, and only 40--60% of t

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18

Battle, Robert A. "Comparison of total and high-density lipoprotein cholesterol in male recreational swimmers and sedentary controls." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/104291.

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19

Nishiga, Masataka. "MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225501.

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20

Roullet, Jean-Baptiste. "Role des derives non steroliques de l'acide mevalonique dans le controle du tonus vasculaire (doctorat : structure et fonctionnement des systemes biologiques integres)." Paris 11, 1998. http://www.theses.fr/1998PA114822.

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21

Journoud, Mélanie. "The effect of plant sterols on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with type 2 diabetes compared with non-diabetic controls /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80296.

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The objective of this study was to compare the effect of phytosterols (PS) on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with or without type 2 diabetes. It was hypothesised that the response to PS would differ between both groups due to different lipid metabolism. During this randomised, double blind, crossover trial, participants consumed a controlled diet with placebo or PS for 21 days.<br>Plasma total cholesterol (TC) decreased with placebo and PS (10.9% and 9.7% in non-diabetic versus 11.6% and 13.6% in diabetic participants, p < 0.05). Plasma low-d

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22

Pereira, Patricia Helena Gilberto Rios. "Lipoproteína de alta densidade (HDL) isolada de portadores de diabete melito tipo 2 com controle glicêmico inadequado favorece o acúmulo de colesterol em macrófagos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-08032010-102308/.

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No diabete melito tipo (DM) 2, a glicoxidação da LDL favorece o acúmulo de colesterol nos macrófagos da parede arterial, enquanto que as modificações da HDL alteram o transporte reverso do colesterol e reduzem sua capacidade ateroprotetora. O objetivo deste estudo foi avaliar a concentração de colesterol livre (CL) e esterificado (CE) em macrófagos, resultante da incubação conjunta de LDL e HDL isoladas de indivíduos portadores de DM 2 (D) com controle glicêmico inadequado, ou de indivíduos controles não diabéticos (C). LDL e HDL isoladas do plasma por ultracentrifugação por gradiente descontí

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23

Padoveze, Amanda Felippe. "Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-25062009-120520/.

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Estudos anteriores em nosso laboratório demonstraram que pacientes portadores de DAC apresentam diferenças no metabolismo do CL e CE de uma nanoemulsão artificial rica em colesterol (LDE), nos quais o CL apresentou maior remoção plasmática e depósito arterial. Dando continuidade a esta linha de pesquisa, neste trabalho foram avaliadas a cinética plasmática, representada pela taxa fracional de remoção (TFR), e a captação do 3H-colesterol livre (3H - CL) e 14C - colesterol esterificado (14C - CE) da LDE por segmentos arteriais e por órgãos de coelhos normais (n=17) e coelhos submetidos à indução

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24

Neto, Oscar Giese Laverdy. "Efeitos do controle glicêmico sobre os lípides séricos e na transferência lipídica para a HDL em pacientes com diabetes mellitus tipo 2: novos achados no status do colesterol não esterificado." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-14012015-154739/.

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Introdução:Uma das causas da doença cardiovascular do diabético é a dislipidemia associada ao diabetes mellitus tipo 2 (DM2), caracterizada basicamente por hipertrigliceridemia e baixa concentração de HDL-colesterol. O bom controle da glicemia geralmente resulta em diminuição dos triglicerídeos plasmáticos, mas há controvérsia na literatura quanto aos níveis de HDL-colesterol e outros parâmetros lipídicos. As transferências lipídicas para a HDL têm importante função na sua formação e remodelamento e no seu papel antiaterogênico do transporte reverso do colesterol. A transferência de lípides en

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25

Bedford, Stephen James. "Calculus of variations and its application to liquid crystals." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a2004679-5644-485c-bd35-544448f53f6a.

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The thesis concerns the mathematical study of the calculus of variations and its application to liquid crystals. In the first chapter we examine vectorial problems in the calculus of variations with an additional pointwise constraint so that any admissible function <strong>n</strong> ε W<sup>1,1</sup>(ΩM), and M is a manifold of suitable regularity. We formulate necessary and sufficient conditions for any given state <strong>n</strong> to be a strong or weak local minimiser of I. This is achieved using a nearest point projection mapping in order to use the more classical results which apply in

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26

Potiron, Aline. "Conversion du cholestérol en coprostanol par les bactéries du microbiote intestinal humain et impact sur la cholestérolémie." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLA036/document.

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La réduction du taux de cholestérol (CH) sanguin est un point clé dans la lutte contre les maladies cardiovasculaires. L’efficacité contrastée des médicaments disponibles actuellement ainsi que l’intérêt porté autour du microbiote intestinal dans la régulation de la physiologie de l’hôte nous amènent à envisager cette voie comme alternative thérapeutique. La production de coprostanol (CO), dérivé très peu absorbé du CH, par des bactéries de ce microbiote a été corrélée positivement à une faible cholestérolémie. Les objectifs de cette thèse sont i) d’isoler et d’identifier de nouvelles souches

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27

Ben, Hassen Celine. "Cibler l'homéostasie du cholestérol cellulaire pour traiter le cancer du sein." Thesis, Tours, 2019. http://www.theses.fr/2019TOUR3809.

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Une femme sur huit sera touchée dans sa vie par le cancer du sein. Les facteurs de risque peuvent être héréditaires et environnementaux. Des études antérieures ont montré que les taux de cholestérol cellulaire peuvent jouer un rôle important dans la régulation de la progression tumorale. Pour confirmer cette hypothèse, nous avons modulé le métabolisme du cholestérol dans les cellules cancéreuses mammaires humaines MCF-7 et MDA-MB-231 en utilisant des approches génétiques : augmentation de l’élimination du cholestérol par l’expression de l’apolipoprotéine A-I (apoA-I, régulant la sortie du chol

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28

Lai, Wei-An, and 賴薇安. "Beyond cholesterol homeostatic control—how ovarian granulosa cells acquire cholesterol for active steroidogenesis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/54418390690068318798.

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博士<br>國立陽明大學<br>生理學研究所<br>101<br>Ovarian granulosa cells are the major producer of female sex steroids progesterone and estrogen. Granulosa cells synthesize progesterone from the steroid precursor cholesterol, whereas estrogen is produced through aromatase catalysis of theca cell-derived androgen. Ovarian local factor TGFbeta1 facilitates the action of pituitary hormone FSH to promote granulosa cell steroidogenesis. It is known that in non-steroidogenic cells, cellular cholesterol is under homeostatic control involving feedback inhibition of HMG-CoA reductase (key enzyme for cholesterol de nov

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29

Lee, Chia-Chun, and 李家淳. "Control over the self-assembled ordered nanostructures of phospholipids by incorporation of cholesterol." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/j6w4af.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>105<br>The interactions between cholesterol and phospholipids have been extensively studied in the aqueous systems. It has been known that the presence of cholesterol can stabilize the cell membrane by inhibiting the movement of hydrocarbon chains. In this study, instead of the self-assembly in aqueous solutions, we probed the impact of cholesterol on the ordered microphase separated structures between the hydrophilic headgroups and the hydrophobic tails of phospholipids in thin film and bulk state. Four phospholipids with varying number of double bonds on the h

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30

Moutinho, Miguel Alves da Silva de Carvalho 1986. "Control of neuronal signalling pathways by CYP46A1, an enzime involved in brain cholesterol homeostasis." Doctoral thesis, 2016. http://hdl.handle.net/10451/23976.

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Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Cholesterol is an essential molecule in central nervous system physiology and cell signalling, with a wide range of roles, such as being an essential component of cell membranes, lipid rafts and myelin sheets, or serving as a precursor for neurosteroids. The brain relies mainly on de novo cholesterol synthesis and eliminates cholesterol through its conversion to 24(S)-hydroxycholesterol (24OHC), which readily crosses the blood brain barrier into circulation. The enzyme that cat

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31

Deng-Juin and 林登圳. "The impact of health education on kidney patients’ blood pressure, FPG, creatinine, total cholesterol, and eGFR: a case control study." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/99598232903729861956.

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博士<br>中山醫學大學<br>醫學研究所<br>98<br>Background: Taiwan has the highest incidence of dialysis population. Since patients’ education has been demonstrated to be a useful tool to level down the progresses of significant to reduce the deterioration of kidney disease. In this study, researches were performed using those patients whose eGFR is lower than 60/mL/min/1.73m2 to determine the impact of health education on their disease parameters including blood pressure, fasting plasma glucose (FPG),creatinine and eGFR. Methods: This was a quasi-experimental study. A total of 223 patients, whose eGFR is lowe

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32

Kranz, Eylath [Verfasser]. "Dietary habits and life style in the etiology of cholesterol gallstone disease : a matched case control study / vorgelegt von Eylath Kranz." 2002. http://d-nb.info/968492649/34.

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33

Chang, Wei-lun, and 張瑋倫. "The Optical Properties of The Cholesteric Liquid Crystal with The Change of It’s Pitch by The Optical Control Method." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/82977472521071036428.

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碩士<br>國立臺灣科技大學<br>高分子系<br>96<br>In this study, Cholesteric liquid crystals were prepared by mixing a nematic liquid crystal (E7),a chiral compound (S811).Cholesteric liquid crystals (Ch LCs) have a helical structure, and selectively reflect light of a wavelength proportional to the helical pitch(p).Dissolving a chiral compound in a nematic LC provides a helical structure corresponding to the concentration of chiral compounds dissolved in the nematic LC. We observe what difference in helical pitch and phase transition temperature depend on the concentration of chiral compounds. Cholesteric liqu

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