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Дисертації з теми ""chirurgia epatica""

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Tuci, Francesco. "Modello predittivo dell'insufficienza epatica irreversibile dopo resezione epatica per epatocarcinoma su cirrosi: il "resection score"." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424698.

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Background and aim Liver resection is the one of the curative therapeutic options for Hepatocellular Carcinoma (HCC) on hepatic cirrhosis, with radical intent, and the best results in terms of survival rate and HCC recurrence can be achieved compared to liver transplantation. The risk of postoperative irreversible liver failure, increased by underlying cirrhosis, is one of the principal limits of liver resection. The aim of this study is to obtain a predictive score of irreversible liver failure and early death post-hepatectomy, available for clinic practice in the assessment of HCC patient

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2

Pacilé, Vincenzo <1975&gt. "Sviluppo di un modello sperimentale di insufficienza epatica acuta post- ischemica nel suino." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2804/2/vincenzo-pacil%C3%A8-Sviluppo_di_un_modello_sperimentale_di_insufficienza_epatica_acuta_post-_ischemica_nel_suino%E2%80%9D.pdf.pdf.

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Pacilé, Vincenzo <1975&gt. "Sviluppo di un modello sperimentale di insufficienza epatica acuta post- ischemica nel suino." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2804/.

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4

Bassi, Domenico. "Resezione epatica maggiore con modulazione del flusso portale nel ratto: studio emodinamico e ruolo della Serpina B3 sul danno cellulare." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424101.

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Background: The increased blood flow per gram of liver immediately after liver resection results in an increase intrahepatic shear stress that seems to be involved in the stimulation and regulation of regeneration. A portal hyperflow however causes a serious liver damage due to high intraparenchymal shear stress. This phenomenon has been studied mainly in living donor liver transplantation or cadaveric split liver and in extreme liver resections. The result is a syndrome defined Small for Size which has many similarities with liver failure after hepatectomy and it is associated with severe mor

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5

Polacco, Marina. "Survival benefit della resezione epatica nel colangiocarcinoma intraepatico avanzato: un'analisi dei dati del SEER (Surveillance, Epidemiology, and End Results)." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422807.

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Background: Liver resection (LR) is the cornerstone in the treatment of Intrahepatic Cholangiocarcinoma (I-CCA). However, it is a controversial solution for advanced lesions not only due to surgical technical aspects but also its survival benefit remains questionable. Aim of the work: The aim of this study is to verify the survival benefits of LR in advanced stages of I-CCA based on the 7th and 8th editions of American Joint Committee on Cancer (AJCC) Staging System, and to identify prognostic factors that directly influence patients’ survival after LR. Methods: A retrospective cohor

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6

D'Amico, Francesco. "Infusione sistemica e loco-regionale di N-ACETIL-CISTEINA nel prelievo di fegato: uno studio prospettico randomizzato controllato." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3427328.

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Background/Aims. Anti-oxidant agents have the potential to reduce the ischemia-reperfusion damage of organs for liver transplantation (LT). In this randomized prospective study, we tested the impact on the post-LT outcome of the infusion of N-acetilcisteina (NAC) during the liver procurement procedure. Methods. The NAC protocol scheduled: a systemic NAC infusion (30 mg/kg) one hour before the beginning of liver procurement; a loco-regional NAC infusion (300 mg through the portal vein) just before cross-clamping. Between December 2006 and December 2007, 56 grafts, assigned to adult candidates

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7

Bonsignore, Pasquale. "Sviluppo di biomarkers per la determinazione e la valutazione prognostica della ripresa funzionale epatica post trapianto, nel fegato marginale e nel non heart beating donor." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423510.

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ABSTRACT Background One of the most crucial issues in liver transplantation is the gap between the increasing number of patients waiting for a transplant and the shortage of available grafts. This limitation has led many liver transplant units to include for surgery organs defined as “marginal” or “sub-optimal” due to hepatic steatosis or sourcing from non-heart-beating donors (NHBD). In turn, the marginality of these organ donors is proportional to a high incidence of liver dysfunction after transplantation due mainly to more severe ischemia-reperfusion injury events. The use of new methods

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8

Bassanello, Marco. "Il trauma epatico: dal trattamento conservativo al trapianto di fegato Analisi di centro." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425177.

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By this study, the results of our treated hepatic trauma patients are conformed to international applicative standards. Particular technologycal aspects than interventistic radiological procedures, surgeon techniques, emergency laparoscopic approach as hepidemiologic or ethyopatogenetic aspects, "golden hour" treatment and other clinical aspects are determinant for successful management of hepatic trauma. Apart from non operative treatment in patients with not complex injuries and hemodynamic clinical stability, and conservative operative techniques that allow successful management in most cas

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9

Mirarchi, Mariateresa <1979&gt. "Resezioni epatiche eco-guidate radicali ma conservative simultanee alle resezioni colo-rettali. Un approccio sicuro al cancro colorettale avanzato." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7006/1/Tesi_Dottorato_def.pdf.

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Il cancro colorettale (CRC) rimane la prima causa di morte nei paesi occidentali.Dal 15% al 25% dei pazienti affetti da CRC presenta metastasi epatiche sincrone (CRLM) al momento della diagnosi.La resezione epatica radicale rimane l’unica terapia potenzialmente curativa in presenza di CRLM con una sopravvivenza a 5 anni compresa tra il 17% ed il 35% ed a 10 anni tra il 16% e il 23% rispettivamente. La tempistica ottimale per la resezione chirurgica in caso di presentazione sincrona di CRC è controversa.Questo studio intende dimostrare che le resezioni epatiche ecoguidate radicali ma conservat

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10

Mirarchi, Mariateresa <1979&gt. "Resezioni epatiche eco-guidate radicali ma conservative simultanee alle resezioni colo-rettali. Un approccio sicuro al cancro colorettale avanzato." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7006/.

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Il cancro colorettale (CRC) rimane la prima causa di morte nei paesi occidentali.Dal 15% al 25% dei pazienti affetti da CRC presenta metastasi epatiche sincrone (CRLM) al momento della diagnosi.La resezione epatica radicale rimane l’unica terapia potenzialmente curativa in presenza di CRLM con una sopravvivenza a 5 anni compresa tra il 17% ed il 35% ed a 10 anni tra il 16% e il 23% rispettivamente. La tempistica ottimale per la resezione chirurgica in caso di presentazione sincrona di CRC è controversa.Questo studio intende dimostrare che le resezioni epatiche ecoguidate radicali ma conservat

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11

Pace, Napoleone Carlo <1966&gt. "Valutazione delle funzioni cardio-respiratorie ed epatiche in pazienti con cuore univentricolare trattati con intervento di connessione cavo-polmonare totale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6856/1/pacenapoleone_carlo_tesi.pdf.

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L'intervento di connessione cavo-polmonare totale (TCPC) nei pazienti portatori di cuore univentricolare, a causa della particolare condizione emodinamica, determina un risentimento a carico di numerosi parenchimi. Scopo della ricerca è di valutare l'entità di questo danno ad un follow-up medio-lungo. Sono stati arruolati 115 pazienti, sottoposti ad intervento presso i centri di Cardiochirurgia Pediatrica di Bologna (52 pz) e Torino (63 pz). Il follow-up medio è stato di 125±2 mesi. I pazienti sono stati sottoposti ad indagine emodinamica (88 pz), test cardiopolmonare (75 pz) e Fibroscan ed

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12

Pace, Napoleone Carlo <1966&gt. "Valutazione delle funzioni cardio-respiratorie ed epatiche in pazienti con cuore univentricolare trattati con intervento di connessione cavo-polmonare totale." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6856/.

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L'intervento di connessione cavo-polmonare totale (TCPC) nei pazienti portatori di cuore univentricolare, a causa della particolare condizione emodinamica, determina un risentimento a carico di numerosi parenchimi. Scopo della ricerca è di valutare l'entità di questo danno ad un follow-up medio-lungo. Sono stati arruolati 115 pazienti, sottoposti ad intervento presso i centri di Cardiochirurgia Pediatrica di Bologna (52 pz) e Torino (63 pz). Il follow-up medio è stato di 125±2 mesi. I pazienti sono stati sottoposti ad indagine emodinamica (88 pz), test cardiopolmonare (75 pz) e Fibroscan ed

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13

Carraro, Amedeo. "Realizzazione multistep di neo-costrutti epatici con apporto vascolare attraverso tecniche di tissue engineering." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427502.

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INTRODUCTION: This multistep work has investigated tissue engineering of the liver as approach for treating end-stage liver diseases by different projects. Engineering of hepatic tissue based on primary hepatocytes offers new perspectives in this field. However, generation of thick, 3D liver tissue has been limited by the lack of vasculature in the engineered constructs; hepatocyte survival is transient if limited by insufficient vascular-network formation. To overcome this limitation and establish a vascularized construct, we firstly worked on designing a novel microfluidic-based bilayer dev

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14

de, Ruvo Nicola <1966&gt. "Ricerca della tolleranza clinica e recidiva di Epatite C nel trapianto di fegato: effetti a lungo termine dell'induzione con anticorpi policlonali anti-timociti." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/265/1/TESI_DOTTORATO_DE_RUVO.PDF.

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15

de, Ruvo Nicola <1966&gt. "Ricerca della tolleranza clinica e recidiva di Epatite C nel trapianto di fegato: effetti a lungo termine dell'induzione con anticorpi policlonali anti-timociti." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/265/.

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16

Gringeri, Enrico. "Un nuovo sistema di perfusione parenchimale per la preservazione del graft epatico per trapianto: valutazione sperimentale sul piccolo e grande animale." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425544.

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Background In liver transplantation one of the most important promblem which has not a solution yet is the large discrepancy between supply and demand for liver transplantation. To expand the pool of organs we should find the way to utilize marginal livers like the Non-heart-beating-donors ones and the fatty grafts. The use of these livers is associated with high incidence of post-operative primary dysfunction caused by the damage due to the Cold Storage preservation in the context of the process of ischaemia- reperfusion in extreme hypothermia (4° C). The utilization of new methods in the

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17

Saracino, Laura. "Coordinamento di Trial Clinici multicentrici finalizzati allo studio e all'ottimizzazione dell'outcome del trapianto epatico." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423830.

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Introduction. Despite being recognized a clinical application for almost thirty years, data are very scarce regarding liver transplant patients’ long term health issues. Patient survival surpasses the 10 year threshold in increasing numbers, exposing this population to risks from chronic use of immunosuppressive drugs. Methods. The Liver Transplantation Centre of Padua coordinated two spontaneous multricentric studies: a longitudinal observational retrospective multicentre (12 Italian Liver Transplant Centres,) assessing long term survival and main characteristics of the recipient population;

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18

Pierobon, Elisa Sefora/ES. "TRATTAMENTO ABLATIVO CON MICROONDE DI METASTASI EPATICHE DA TUMORE DELLA MAMMELLA: STUDIO DI FATTIBILITÀ ED EFFICACIA." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426792.

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INTRODUCTION Prognosis of patients with breast cancer liver metastases is still dismal. Some retrospective data support adjuvant surgery in selected patients. Ablative treatment in the management of breast cancer liver metastases remains controversial. MATERIAL AND METHODS We evaluated the efficacy (complete ablation and recurrence rate) and the safety (morbidity and mortality) of the microwave ablation treatment (MWA) of breast cancer liver metastases, performed in our Center from 2009 to 2016. Analysis was performed on a nodule-oriented and patient-oriented base. RESULTS Median t

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19

Scopelliti, Michele. "Nuova tecnica di autotrapianto di fegato in un modello sperimentale porcino con preservazione del graft in machine perfusion: applicazione clinica per neoplasie epatiche non resecabili tramite chirurgia convenzionale." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424160.

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A NEW LIVER AUTOTRANSPLANTATION TECHNIQUE USING SUBNORMOTHERMIC MACHINE PERFUSION FOR ORGAN PRESERVATION IN A PORCINE MODEL: CLINICAL INDICATION FOR THE TREATMENT OF UNRESECTABLE HEPATIC LESIONS WITH CONVENTIONAL SURGERY ! Abstract ! BACKGROUND: Hepatic resection is the gold standard of therapy for primary and secondary liver tumors, but few patients are eligible for this procedure because of the extent of their neoplasms. Improvements in surgical experience of liver transplantation (OLT), hepatic resection and preservation with sub-normothermic machine perfusion (MP) have prompted the de

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20

Mammano, Enzo. "Applicazione del Reverse Phase Protein Array per l'analisi del profilo fosfoprotemico nelle metastasi epatiche da carcinoma del colon-retto e identificazione di nuovi bersagli terapeutici." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425595.

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Background Hepatic metastases from colorectal cancer are still characterized by a poor prognosis as only 20% of patients can undergo surgical resection and in the other 80% chemotherapy achieves short results with a 5-years survival lower than 5%. Protein-kinases play a crucial role in determinating alterations of intracellular signal transmission that are basis for neoplastic and metastatic process. Reverse phase protein array is a technique that allow simultaneous analysis of the phosphorilation state from different specimens and consequently the activation of protein-kinases. Aim of the

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21

Ciarleglio, Francesco Antonio. "Impatto prognostico delle resezioni epatiche allargate nel trattamenti del colangiocarcinoma ilare nell'era genomica: Analisi di centro." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421597.

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Cholangiocarcinoma, which arises from intrahepatic or extrahepatic bile ducts, is a relatively uncommon malignant neoplasm; however, incidence is increasing world wide. This disease is reported to occur more frequently in Japan than in Western countries with approximately 16,000 deaths per year from biliary tract cancer in Japan. Cholangiocarcinoma has commonly been classified into 3 broad categories based on tumor location: intrahepatic, hilar, or distal. Hilar cholangiocarcinoma (Klatskin tumor) is an uncommon neoplasm arising from the biliary confluence or the right or left hepatic ducts.

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22

Violi, Paola. "Perioperative blood loss and transfusions in liver transplant: risk factors and impact on transplant outcome - a single european centre experience." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422559.

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Introduction Intraoperative blood transfusions are associated with adverse liver transplantation outcomes and lower patient survival rates. Standard recommendations and guidelines on blood transfusions in liver transplantation are lacking, and a large part of the literature tried to identify risk factors of intraoperative bleeding and blood loss. In the present study a retrospective analysis of the factors correlated to blood loss and transfusion requirements during liver transplanation was performed. Materials and Methods Pre, intra and post operative recipient variables and donor d

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23

Bertazza, Loris. "Analisi delle Cellule Tumorali Circolanti nel carcinoma gastrico e nelle metastasi epatiche da cancro del colon-retto: ruolo di Survivin e CD133 come fattori prognostici." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427460.

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Background At present the only prognostic system routinely employed for the management of gastric cancer patients is the TNM staging classification, that identifies broad risk categories with a significant prognostic variability within each stage, which makes TNM a suboptimal predictive tool on the single patient basis. Only 10-20% of patients with liver metastases from colorectal cancer is resectable with radical intent and 60-70% will develop a relapse despite apparently curative surgery. Both these classes of patients therefore would benefit from additional treatments after surgery suc

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24

f, staderini. "Sviluppo di un sistema di coagulazione a microonde per l'impiego in chirurgia epatica miniinvasiva e robotica." Doctoral thesis, 2020. http://hdl.handle.net/2158/1248543.

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During the last two decades, many surgical procedures have been evolved from traditional open surgery to less invasive or minimally invasive surgery. This limited invasiveness has motivated the development of robotic assistance platforms used during the surgical intervention to obtain better surgical outcomes. Nowadays, the da Vinci robotic system is the commercial robotic platform mostly used for modern minimally invasive surgical applications. Even in the field of minimally invasive hepatic surgery the Da Vinci Platform has been used, but not widely as in other organs such as prostate

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25

PROPOSITO, Delia. "Valutazione dei fattori di rischio nell'incidenza di trombosi dell'arteria epatica in una serie consecutiva di 687 trapianti di fegato." Doctoral thesis, 2000. http://hdl.handle.net/11573/487976.

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26

COCCIA, FEDERICA. "Obesità severa e nafld in pazienti con e senza diabete tipo 2 prima e dopo chirurgia bariatrica: studio degli indici non invasivi di steatosi e fibrosi e dei livelli plasmatici di acidi biliari come predittori di severità dell’istologia epatica." Doctoral thesis, 2020. http://hdl.handle.net/11573/1363031.

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Background Obese subjects are at high risk of nonalcoholic fatty liver disease (NAFLD) and diabetes (T2D) due to insulin resistance (IR). Since high glucose levels are as toxic as lipids for hepatic metabolism, we hypothesize that altered response to oral glucose tolerance test (OGTT) is associated to more severe NAFLD with significant/advanced liver damage. Methods and Results We studied 90 subjects with morbid obesity (73F/17M, BMI=43.2±5,9Kg/m2) undergoing bariatric surgery and intraoperative liver biopsy, and measured HbA1c, HOMA-IR (fasting Glucose x Insulin/22.5), OGTT glucose and

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