Дисертації з теми "Chemotherapy-induced mucositis"
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Mulholland, K. C. "Experimental chemotherapy-induced mucositis." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479433.
Повний текст джерелаKoning, Barbara Anna Eleonora de. "Chemotherapy induced intestinal mucositis: from bench to bed." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/10865.
Повний текст джерелаTran, Cuong Duy. "Intestinal zinc and metallothionein : role in chemotherapy-induced mucositis." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc9736.pdf.
Повний текст джерелаBowen, Joanne Marie. "Chemotherapy-induced intestinal mucositis the role of apoptosis regulators /." Click here to access, 2006. http://thesis.library.adelaide.edu.au/public/adt-SUA20060831.142913/index.html.
Повний текст джерелаIncludes author's previously published papers. "March 2006" Bibliography: leaves 168-191. Also available in a print form.
Bingham, J. M. M. "Gut mucosal architecture and barrier function in chemotherapy induced mucositis." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411063.
Повний текст джерелаWilliams, Evan, and Jacob Dale Stearley. "Physicochemical Properties of a ‘Magic Mouthwash’ for Chemotherapy Induced Oral Mucositis." The University of Arizona, 2011. http://hdl.handle.net/10150/623534.
Повний текст джерелаOBJECTIVES: To determine the solubility and stability of hydrocortisone in a ‘magic mouthwash; suspension. METHODS: A literature review was conducted to establish the most common ingredients in a ‘magic mouthwash’ suspension It was decided that the test suspension would consist of 75% commercially available diphenhydramine solution, 12.5% nystatin suspension (100,000 units/ml) , and 12.5% lidocaine solution (2% lidocaine). Powdered hydrocortisone was then added to the test suspensions at different concentrations and stored at 27C, 38C, and 48C. Aliquots were taken from each of the test samples at the time of compounding and at 4, 7, 13, 19, and 26 days to be analyzed by HPLC for degradation of hydrocortisone and percent hydrocortisone in suspension. RESULTS: At 27C, 98.5% of hydrocortisone was recovered after 26 days, versus 33.7% at 38C, and 7% at 48C. The solubility of hydrocortisone in the suspension was higher at higher temperatures, with 82% in solution at 48C, 70% at 38C, and 38% at 27C. CONCLUSION: The amount of hydrocortisone recovered deteriorated over time and at higher temperatures, and solubility of hydrocortisone in the suspension was greater at higher temperatures.
Gibson, Rachel J. "Chemotherapy-induced mucositis : mechanisms of damage, time course of events and possible preventative strategies /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phg4481.pdf.
Повний текст джерелаPoon, Sze-wan, and 潘詩尹. "An evidence-based guideline on using cryotherapy for chemotherapy-induced oral mucositis in adult cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48339192.
Повний текст джерелаpublished_or_final_version
Nursing Studies
Master
Master of Nursing
Hotama, Peggy Yulia [Verfasser]. "The role of Herpes Simplex Virus in chemotherapy-induced Mucositis in pediatric patients / Peggy Yulia Hotama." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052530168/34.
Повний текст джерелаIvester, Clifford. "15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.
Повний текст джерелаRodrigues, Andréia Catarina Dias. "Predictive factors for chemotherapy-induced oral mucositis in colorectal cancer patients: role of inflammatory related genes polymorphisms." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/9150.
Повний текст джерелаRodrigues, Andréia Catarina Dias. "Predictive factors for chemotherapy-induced oral mucositis in colorectal cancer patients: role of inflammatory related genes polymorphisms." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/9150.
Повний текст джерелаThomsen, Michael. "The Effect of a Multi-Species Probiotic Formulation to Prevent Chemotherapy-induced Diarrhoea by Rescuing Gastrointestinal Dysbiosis and Mucositis. A Feasibility Probing Study." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29447.
Повний текст джерелаLou, Yan. "Self-management of cancer treatment-related fatigue, nausea, vomiting and oral mucositis in Chinese cancer patients." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/44127/1/Yan_Lou_Thesis.pdf.
Повний текст джерелаCardani, D. "SGLT-1: A NEW THERAPEUTIC STRATEGY TO MAINTAINS INTESTINAL EPITHELIAL INTEGRITY AND BARRIER FUNCTION." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/215121.
Повний текст джерелаFreitas, Ana Paula Fragoso de. "Protein fraction of latex Calotropis procera protects against induced oral mucositis 5-Fluorouracil in hamsters through inhibition proinflammatory mediators." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9245.
Повний текст джерелаCoordenaÃÃo de AperfeiÃoamento de NÃvel Superior
Oral mucositis (OM) induced by antineoplasic drugs is an important, dose-limiting, and costly side effect of cancer therapy. Calotropis procera is a plant plant constitutively produces abundant latex that is reported to possess anti-inflammatory, bacteriolytic, insecticidal, analgesic properties. The present work aimed to describe the effect of laticifer proteins of Calotropis procera (LP) in the expression of pro-inflammatory cytokines and inducible enzymes, such as, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in the model of OM in Hamsters. OM was induced by two intraperitoneal (i.p.) administrations of 5-Fluorouracil (5-FU) on the 1st and 2nd days (60 and 40 mg/kg, respectively) in hamsters (n=5). LP (0,25; 1; 5 E 25 mg / kg) was injected i.p. 24h before and 24h after mechanical trauma of the cheek pouches. Control group received only saline. On the 10th day, the animals were sacrificed and tissues from the cheek pouches were harvested. Macroscopical and histopathological (inflammatory cell infiltration, edema, hemorrhage and the formation of ulcerations and abscess) analysis as well as immunohistochemistry for TNF-, IL-1β, iNOS and COX-2 was performed in the cheek pouch tissue. Kruskal Wallis/Dunn was used as statistical tests. P<0.05 was accepted. Ethics Committee 036/10. The LP significantly inhibited macroscopical and histopathological parameters when compared to control group with maximum effect in macroscopic scores reaching 75% and 66% of maximum effect at the histopathological evaluation. The MPO activity was also significantly inhibited by LP in 91% at the same dose (p<0,001) and also inhibited the lost weight of 5- FU induced-oral mucositis. The cheek pouches of hamsters submitted to OM showed marked immunostaining for TNF-, IL-1β, iNOS and COX-2 on inflamed conjunctive (Cj) and epithelial (Ep) tissue compared with the cheek pouches of the normal control group. LP caused considerable reduction in the immunostaining for TNF- (62%,Cj; 70%,Ep), IL-1β (87%,Cj; 80%,Ep), iNOS (82%Cj; 52%Ep) and COX-2 (70%,Cj; 100%,Ep) in the check pouches tissue when compared with the group of animals subjected to experimental mucositis that received saline instead of LP. These findings show anti-inflammatory effects of LP in 5-FU-induced OM. The protective effect could be supported by the reduction of the expression of pro-inflammatory cytokines, such as TNF- and IL-1β and the enzymes iNOS and COX-2. The protective mechanism appears to involve inhibition of the expression of iNOS, COX-2, TNF-, and IL- 1β.
Mucosite oral (MO) induzida por drogas antineoplÃsicas à um importante fator limitante da dose e efeitos colaterais da terapia do cÃncer. Calotropis procera à uma planta que produz lÃtex constitutivamente abundante que à relatado possuir propriedades antiinflamatÃrias, bactericidas, inseticidas, analgÃsicas. O presente trabalho teve como objetivo descrever o efeito das proteÃnas do lÃtex da Calotropis procera (LP) na expressÃo de citocinas prÃ-inflamatÃrias (TNF-α e IL-1) e enzimas induzÃveis, como, ciclooxigenase-2 (COX-2) e Ãxido nÃtrico sintase induzÃvel (NOSi) no modelo de MO em hamsters. A mucosite oral foi induzida por duas administraÃÃes intraperitoneal (i.p) de 5-fluorouracil (5-FU) no 1  e 2 dias nas doses de 60 e 40 mg/kg, respectivamente nos animais (n = 5). As LP (0,25; 1; 5 E 25 mg/kg) foi injetado via i.p. 24h antes e 24h apÃs o trauma mecÃnico da mucosa jugal. O grupo controle recebeu apenas soluÃÃo salina. No 10 dia, os animais foram sacrificados e os tecidos da mucosa jugal foram colhidos. Foram realizadas no tecido mucosa jugal as anÃlises macroscÃpicas e histopatolÃgicas (infiltraÃÃo de cÃlulas inflamatÃrias, edema, hemorragia e à formaÃÃo de ulceraÃÃes e abscessos), bem como a imunohistoquÃmica para TNF-α, IL-1β, NOSi e COX-2. Foram utilizados Kruskal Wallis / Dunn como testes estatÃsticos, onde P <0,05 foi aceito. O estudo foi submetido ao Comità de Ãtica sob o protocolo 036/10. Observou-se que a LP inibiu significativamente parÃmetros macroscÃpicos e histopatolÃgicos, quando comparado ao grupo controle, com efeito mÃximo nos escores macroscÃpicos atingindo 75% e 66% do efeito mÃximo na avaliaÃÃo histopatolÃgica. A atividade de Mieloperoxidase (MPO) tambÃm foi significativamente inibida por LP em 91% com a mesma dose (p <0,001) quando comparado ao grupo controle e tambÃm inibiu a perda de peso em animais submetidos a mucosite oral e tratados com LP. A mucosa jugal dos animais submetidos a MO mostrou imunomarcaÃÃo para TNF-α, IL-1β, NOSi e COX-2 na conjuntiva inflamada (Cj) e tecido epitelial (Ep) em comparaÃÃo com o tecido jugal do grupo normal. LP causou reduÃÃo considerÃvel na imunomarcaÃÃo para TNF-α (62%, Cj, 70%, Ep), IL-1β (87%, Cj, 80%, Ep), NOSi (82% Cj; Ep 52%) e COX -2 (70%, Cj, 100%, Ep) no tecido jugal quando comparado com o grupo de animais submetidos à mucosite experimental que receberam salina, em vez de LP. Esses achados demonstram efeitos anti-inflamatÃrios de LP em MO induzida por 5-FU. O efeito protetor poderia ser suportado pela reduÃÃo da expressÃo das citocinas prÃ-inflamatÃrias, como TNF-α e IL-1β e na expressÃo de enzimas COX-2 e NOSi. O mecanismo de proteÃÃo parece envolver a expressÃo inibitÃria da NOSi, COX-2, TNF-α e IL-1β.
YouLee and 李優. "Study of IL-19 in Chemotherapy-induced Intestinal Mucositis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/z5tn3t.
Повний текст джерелаBowen, Joanne M. "Chemotherapy - induced intestinal mucositis : the role of apoptosis regulators." 2006. http://hdl.handle.net/2440/37829.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2006.
Bowen, Joanne M. "Chemotherapy - induced intestinal mucositis : the role of apoptosis regulators." Thesis, 2006. http://hdl.handle.net/2440/37829.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2006.
Al-Dasooqi, Noor. "Chemotherapy-induced mucositis : the role of matrix metalloproteinases and the extracellular matrix." Thesis, 2012. http://hdl.handle.net/2440/72769.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2012
"Oral care intervention to alleviate chemotherapy-induced oral mucositis in children with cancer." 2001. http://library.cuhk.edu.hk/record=b6073393.
Повний текст джерела"November 2001."
Thesis (Ph.D.)--Chinese University of Hong Kong, 2001.
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Mode of access: World Wide Web.
Abstracts in English and Chinese.
Huang, Yi Fang, and 黃意方. "Assessment of the Gene Expression in Chemotherapy Induced Oral Mucositis by Transcriptomic Analysis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/43995807624562891492.
Повний текст джерела長庚大學
顱顏口腔醫學研究所
101
Objectives: Chemotherapy plays important role in current cancer therapy, but there are still many unsolved problems about host-therapeutics interaction. The aim of this study was to investigate the host responses after the 5-flurouracil (5-FU) administration and tried to find the target gene of 5-FU-induced oral mucositis via disease-animal model and transcriptomic analysis. Materials and Methods: We wanted to identify the target gene of 5-FU-induced oral mucositis. 5-FU-induced in oral mucositis was established by intraperitoneally administering mice with 100 mg/kg 5-FU. We evaluated the oral mucosal change under macroscopic and histological analysis first, and then transcriptomic analysis of gene expression profile was applied to identify the critical molecule associated with 5-FU-induced oral mucositis. Results: Our data showed that 5-FU-induced inflammation in the oral mucosa characterized by the erythema, hemorrhage, extensive ulcers, abscesses and inflammatory cell infiltration in oral mucosa. Network analysis of the 5-FU-affected genes by transcriptomic tool showed that the gene expression of Chitinase 3-like 4 (Chi3l4) and Bone gamma-carboxyglutamate protein, related sequence 1 (Bglap-rs1) were significant downregulated by 5-FU. Conclusion: 5-FU can down-regulate the gene expression of Chi3l4 and Bglap-rs1 then induce the oral mucositis.
Stringer, Andrea M. "Chemotherapy-induced mucositis : the role of gastrointestinal microflora and mucins in the luminal environment." 2009. http://hdl.handle.net/2440/54968.
Повний текст джерелаhttp://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1352119
Thesis (Ph.D.) - University of Adelaide, School of Medicine, 2009
Stringer, Andrea Marie. "Chemotherapy-induced mucositis : the role of gastrointestinal microflora and mucins in the luminal environment." Thesis, 2009. http://hdl.handle.net/2440/54968.
Повний текст джерелаThesis (Ph.D.) - University of Adelaide, School of Medicine, 2009
Gibson, Rachel J. (Rachel Jane). "Chemotherapy-induced mucositis : mechanisms of damage, time course of events and possible preventative strategies / Rachel J. Gibson." 2004. http://hdl.handle.net/2440/22100.
Повний текст джерелаBibliography: leaves 121-142.
xviii, 142, [19] leaves : ill. (some col.), plates (some col.) ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
Attempts to build a complete understanding of the cellular mechanisms associated with gastrointestinal mucositis through investigations of the effects throughout the gastrointestinal tract of chemotherapeutic agents Methotrexate and Irinotecan, the possible ameliorating potential of the cytokine Interleukin-11 in reducing the side effects of chemotherapy, the expression of pro- and anti-apoptopic proteins and transcription factors along the gastrointestinal tract in normal human patients and the time-course of development of oral mucositis in human patients. Suggests that the entire gastrointestinal tract follows a similar pattern of development of mucositis.
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2004
Gibson, Rachel J. (Rachel Jane). "Chemotherapy-induced mucositis : mechanisms of damage, time course of events and possible preventative strategies / Rachel J. Gibson." Thesis, 2004. http://hdl.handle.net/2440/22100.
Повний текст джерелаBibliography: leaves 121-142.
xviii, 142, [19] leaves : ill. (some col.), plates (some col.) ; 30 cm.
Attempts to build a complete understanding of the cellular mechanisms associated with gastrointestinal mucositis through investigations of the effects throughout the gastrointestinal tract of chemotherapeutic agents Methotrexate and Irinotecan, the possible ameliorating potential of the cytokine Interleukin-11 in reducing the side effects of chemotherapy, the expression of pro- and anti-apoptopic proteins and transcription factors along the gastrointestinal tract in normal human patients and the time-course of development of oral mucositis in human patients. Suggests that the entire gastrointestinal tract follows a similar pattern of development of mucositis.
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2004
Abimosleh, Suzanne Mashtoub. "Emu oil promotes intestinal repair in rat models of enteric inflammation." Thesis, 2013. http://hdl.handle.net/2440/90798.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medical Sciences, 2013
Sung, Lillian. "Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in pediatric patients: A pilot study /." 2004. http://proquest.umi.com/pqdweb?did=1188870261&sid=1&Fmt=2&clientId=12520&RQT=309&VName=PQD.
Повний текст джерелаPrisciandaro, Luca David. "Probiotic-derived factors for the treatment and prevention of 5-fluorouracil-induced intestinal mucositis." Thesis, 2013. http://hdl.handle.net/2440/96820.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Animal and Veterinary Sciences, 2013
Wardill, Hannah Rose. "Toll-like receptor 4-dependent barrier dysfunction and its impact on irinotecan-induced gut toxicity and pain." Thesis, 2016. http://hdl.handle.net/2440/106719.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2016.