Дисертації з теми "Chemistry major"
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Angell, Scott Edward. "Genomic and metagenomic approaches to natural product chemistry." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2671.
Повний текст джерелаSanchez, Richard P. Jr. "Cationic Ruthenium Catalysts for Olefin Hydrovinylation." [College Station, Tex. : Texas A&M University, 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-2929.
Повний текст джерелаLi, Chunmei. "Designing phase selective soluble polymers for applications in organic chemistry." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969/105.
Повний текст джерелаCao, Qianwen. "Mass Balance of Major, Minor and Trace Elements During AFBC Combustion of Fuels." TopSCHOLAR®, 1997. http://digitalcommons.wku.edu/theses/899.
Повний текст джерелаZavala-Ruiz, Zarixia 1977. "Structure studies of the human class II major histocompatibility complex protein HLA-DR1." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/17842.
Повний текст джерелаVita.
Includes bibliographical references (leaves 149-162).
Major Histocompatibility Complex (MHC) proteins are heterodimeric membrane glycoproteins that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In this thesis work, the structural aspects of the human class II MHC protein HLA-DR1 in complex with different peptides and also in the peptide-free form were investigated. Biochemical, crystallographic, and immunological analyses of an unusually long peptide antigen derived from HIV-gag (p24) and its interaction with HLA-DR1 and a HIV-specific CD4+ T cell clone were studied. The HIV-gag (p24) peptide binds in an unexpected conformation, with its C- terminal region making a hairpin turn that bends back over the groove. The residues at the C-terminus are critical for T-cell recognition, and disruption of the hairpin turn abrogates the immune response. The results suggest a new mode of MHC-peptide-TCR interaction. A set of viral peptide analogs designed to increase binding affinity for HLA-DR while maintaining antigenic interactions with a virus-specific T cell receptor were designed, tested and analyzed. Ultimately, a N-methyl substitution at position 7 is shown to increase binding affinity by displacement of one of three water molecules bound between the MHC and peptide. The results have implications for design of peptido-mimetic vaccines, and are discussed in the broad context of other attempts to increase protein-ligand interaction through displacement of tightly bound water molecules. The role for the P10 shelf in peptide binding site was investigated. Crystallographic studies confirm the formation of a P10 shelf that is lined with highly polymorphic residues. Biochemical studies were conducted
(cont.) on a series of peptides different at the P10 position on four HLA-DRl(P10) mutants showing that this shelf has some specificity and can be involved in the discrimination of peptides that bind to class II MHC proteins. Studies of the empty, peptide-free form of HLA-DR1 were conducted by NMR spectroscopy showing that the conformation of this empty form is not in a molten globule-like state and that in general is similar to that of the peptide-loaded form but with several differences. Preliminary characterization of the peptide-receptive and peptide-averse forms of the empty HLA-DR1 is described.
by Zarixia Zavala-Ruiz.
Ph.D.
Carven, Gregory J. (Gregory John) 1975. "Insight into the structure and function of empty class II major histocompatibility complexes." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/17736.
Повний текст джерелаVita.
Includes bibliographical references.
Class II major histocompatibility complex (MHC) proteins bind peptides and present them at the cell surface for interaction with CD4+ T cells as part of the system by which the immune system surveys the body for signs of infection. Peptide binding is known to induce conformational changes in class II MHC proteins on the basis of a variety of hydrodynamic and spectroscopic approaches, but the changes have not been clearly localized within the overall class II MHC structure. Local structural changes were mapped for HLA-DR1, a common human class II MHC variant, using a series of monoclonal antibodies which recognize the beta subunit and are specific for the empty conformation. Additional structural information was obtained using side chain-specific chemical modification and identification of modified residues by in-gel tryptic digestion and mass spectrometric peptide mapping. Together, the chemical modification studies and the mapping results illuminate aspects of the structure of the empty forms and the nature of the peptide-induced conformational change. Empty class II MHC proteins have been observed on the surface of immature dendritic cells in both humans and mice. Immature DC also secrete a protease activity that is capable of generating antigenic peptides from whole antigen. The protease activity secreted by dendritic cells is characterized and the role of empty MHC proteins in dendritic cell antigen presentation is discussed.
by Gregory J. Carven.
Ph.D.
Lim, Ah Kee. "Factors influencing career choice of bioscience and chemistry double major graduates from Malaysia." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28021.
Повний текст джерелаKorley, Robert E. C. "Characterization of a major protein of the mouse perinuclear theca." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/MQ64383.pdf.
Повний текст джерелаRishard, Mohamed Zuhair Mohamed. "Spectroscopic and theoretical investigation of selected cyclic and bicyclic molecules in their ground and excited electronic states." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2030.
Повний текст джерелаStelzhammer, Viktoria. "Major depressive disorder : molecular profiling to aid drug target discovery." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607830.
Повний текст джерелаJeffery, Stephen Paul. "Metallodithiolate ligands as building blocks for molecular constructions." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1707.
Повний текст джерелаAngell, Yu Li. "Triazole based peptidomimetics for mimicking protein-protein hot spots." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1432.
Повний текст джерелаMarti, Arbona Ricardo. "Mechanistic characterization of members of the amidohydrolase superfamily." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1055.
Повний текст джерелаLiu, Jing. "Heterocyclic small molecule peptidomimetics." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3125.
Повний текст джерелаGuo, Yuyan. "Mixed ionic and electronic conducting electrode studies for an alkali metal thermal to electric converter." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1053.
Повний текст джерелаRuiz, N. Rebecca. "Non-eyring temperature dependence of dynamic isotope effects." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1057.
Повний текст джерелаTaylor, Vanessa Claire. "Biology of the CD52 antigen, a major glycoprotein of human lymphocytes." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242883.
Повний текст джерелаAldulaijan, Sarah. "Theoretical prediction of the interaction between peptides and major histocompatibility Complex II Receptor." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/33376/.
Повний текст джерелаChance, Brandon Scott. "Layer-by-layer assembly on polyethylene films via "click" chemistry." Thesis, [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1252.
Повний текст джерелаLuo, Kai. "Spectroscopic characterization of monometallic and bimetallic model catalysts." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1709.
Повний текст джерелаPrice, Craig Justin. "Structure-activity relationships in olefin polymerization catalysts." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1678.
Повний текст джерелаVenturi, Chantal Margot. "Stratigraphy, petrography and major element mineral chemistry of the Wadi Qutabah Layered Mafic Complex, Yemen." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44059.
Повний текст джерелаSridhar, Rajesh. "Chemistry models for major gas species estimation and tar prediction in fluidized bed biomass gasification." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104564.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 133-140).
The present work deals with the process of fluidized bed biomass gasification (FBBG), which is the thermochemical conversion of solid biomass into combustible synthetic gas using a fluidized bed. Fluidized bed gasifiers encounter high tar concentrations at the gasifier outlet necessitating expensive downstream cleaning equipment. Apart from the complex chemical pathways involved, tar production is also strongly dependent on the transport processes occurring inside the gasifier. Hence, the development of a detailed model to predict the variation of tar production under different operating conditions needs to include two important considerations: a comprehensive chemical kinetic sub-model and a detailed hydrodynamic sub-model. However, due to the huge computational expense associated with such a detailed simulation coupling the complex chemistry and hydrodynamics, there is a need to develop simplified models on both fronts. The first part of this work presents a detailed discussion on the chemistry models for biomass gasification: after introducing the existing state-of-the-art reaction mechanisms (both detailed and compact), two new global chemistry models, incorporating a global primary tar cracking reaction, for air-blown gasification and steam-blown gasification conditions are developed. The major gas species and total tar concentrations predicted using the global models in reactor network simulations of the gasifiers are compared with the corresponding predictions obtained using the detailed CRECK mechanism for biomass gasification, as well as with the available experimental observations. On the hydrodynamics front, an improved reactor network model based on the two-phase theory has been developed to better capture the mixing inhomogeneities in the bubbling fluidized bed, including mass transfer considerations between the bubble and emulsion phases. Finally, the predictions of various tar class concentrations and major gas species concentrations, obtained using the improved reactor network model in conjunction with the detailed CRECK kinetic reaction mechanism, for both air-blown gasification and steam gasification, are presented. Key words: Biomass gasification, Fluidized beds, Chemical reactor network modeling, chemical kinetics, chemistry mechanism reduction, Global chemistry model
by Rajesh Sridhar.
S.M.
Chi, Xiaoliu. "Development of Methods for the Determination of Major and Minor Elements and Hydrocarbon Residues in Solid Combustion Products." TopSCHOLAR®, 1997. http://digitalcommons.wku.edu/theses/772.
Повний текст джерелаOrtiz-Acosta, Denisse. "Phase selectively soluble polymer supports to facilitate homogeneous catalysis." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2451.
Повний текст джерелаJongsma, Candice Gene. "Investigating cotranslational integration of a multi-spanning membrane protein into the endoplasmic reticulum membrane." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2894.
Повний текст джерелаMcElmurry, Blake Anthony. "A co-axially configured submillimeter spectrometer and investigations of hydrogen bound molecular complexes." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2325.
Повний текст джерелаSlaton, James Garrett. "Structure-property relationships in gas-phase protonated and metalated peptide ions." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1260.
Повний текст джерелаChristian, Chad F. "The experimental and theoretical determination of combinatorial kinetic isotope effects for mechanistic analysis." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1253.
Повний текст джерелаReinheimer, Eric Wade. "Hybrid inorganic-organic, organic charge transfer, and radical based compounds with chalcofulvalene donors and organic acceptors." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2452.
Повний текст джерелаLester, Sandy Marie. "Lipoprotein subclass analysis by immunospecific density." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3123.
Повний текст джерелаZhao, Qinliang. "Conformation and electronic configuration of complexes with multiple dimetal units." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1441.
Повний текст джерелаKurzman, Amanda Lord. "Changes in major solute chemistry as water infiltrates soils comparisons between managed agroecosystems and unmanaged vegetation /." Diss., Connect to online resource - MSU authorized users, 2006.
Знайти повний текст джерелаCordeiro, Raposo Fernando. "Chromatographic studies of major milk proteins : towards a reliable method for the assessment of milk authentication." Thesis, University of the West of England, Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275891.
Повний текст джерелаSmith, Michael Joseph 1968. "In vitro filament formation by the major sperm protein (MSP) of Caenorhabditis elegans." Thesis, The University of Arizona, 1993. http://hdl.handle.net/10150/278319.
Повний текст джерелаSrikumar, Ramakrishnan. "Topology of porin, the major outer membrane protein of Haemophilus influenzae type b." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40261.
Повний текст джерелаBased on parameters of hydrophilicity and amphiphilicity a model for Hib porin was generated. The model proposed an organization of sixteen anti-parallel $ beta$-strands that traverse the outer membrane, eight long loops that connect the $ beta$-strands on one side and short turns on the other side.
By flow cytometry, six out of a panel of nine monoclonal antibodies against Hib porin recognized amino acid sequences at the cell surface. Hib porin was purified and subjected to chemical and enzymatic digestions. The fragments were immunoblotted; N-terminal sequencing identified boundaries of fragments. C-terminal deletions of Hib porin generated in the baculovirus expression system identified C-terminal boundaries of monoclonal antibody reactivities.
To map precisely the primary sequences to which these monoclonal antibodies bound, overlapping hexapeptides for the entire sequence of Hib porin were synthesized. These studies identified two surface-exposed regions in the mature sequence of Hib porin, amino acid residues 162-172 and 318-325. In the Hib porin model, these regions correspond to loops 4 and 8, respectively. Two regions between residues 112-126 (loop 3) and residues 148-153 were buried or inaccessible at the surface of the outer membrane.
Recombinant Hib porin was expressed in Bacillus subtilis. The biophysical and immunological properties of this lipooligosaccharide-free recombinant Hib porin were compared with those of native Hib porin.
In order to examine the role of loop 3, site-directed mutagenesis of the cloned Hib porin gene was undertaken. Six or twelve amino acid deletions in loop 3, expressed in a porin deletion strain, showed significant increase in sensitivities to several anti-microbial agents as compared to wild-type Hib porin. Deletion of twelve amino acids showed more pronounced phenotypes than deletion of six amino acids. Such mutagenesis experiments provided support to the notion that loop 3 in Hib porin folds back into the pore and produces a constriction of the channel.
Loudet, Aurore. "Design of novel dyes towards the near-infrared." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2449.
Повний текст джерелаVasquez, Yolanda. "Low-temperature solution synthesis of alloys and intermetallic compounds as nanocrystals." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3130.
Повний текст джерелаHenkes, Amanda Erin. "Solution-mediated strategies for synthesizing metal oxides, borates and phosphides using nanocrystals as reactive precursors." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2674.
Повний текст джерелаChandra, Richa. "The analysis of triglyceride-rich lipoproteins in human serum for clinical studies." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1745.
Повний текст джерелаGanguly, Poulomi. "Metal salen catalyzed production of polytrimethylene carbonate." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1706.
Повний текст джерелаJin, Jiayi. "Studies of electronic communication between dimolybdenum cores joined by various bridges." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1434.
Повний текст джерелаSweet, Lucas Edward. "Synthesis, structure and magnetic properties of lanthanide cluster compounds." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3128.
Повний текст джерелаGrill, Joseph Michael. "The design of new ligands and transition metal compounds for the oxidation of organic compounds." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1746.
Повний текст джерелаMoreno, Karlos Xavier. "NMR studies of the conformation of a triazine dendrimer and the synthesis of a platinated triazine dendrimer." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2450.
Повний текст джерелаStumpo, Katherine Anne. "Size-selected 2, 5, and 10 nm gold nanoparticles for laser desorption/ionization mass spectrometry." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3127.
Повний текст джерелаTaylor, Thomas Jackson. "Synthesis and material properties of supramolecules containing fluorinated organomercurials." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1261.
Повний текст джерелаLiu, Qingsong. "Large scale total synthesis of apoptolidinone and progress towards the total synthesis of ammocidin." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1054.
Повний текст джерелаIlg, Andrea Diane. "The effect of branch density polyoxymethylene copolymers." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1258.
Повний текст джерелаFrantz, Eric Benjamin. "Synthesis, reactivity, and coordination chemistry relevant to the copolymerization of CO2 and epoxides by first row transition metal schiff base complexes." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2893.
Повний текст джерела