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Статті в журналах з теми "Central blood pressure, atherosclerosis, subclinical organ damage"
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Druzhilov, M. A., V. V. Otmakhov, Yu E. Beteleva, V. A. Korneva, and T. Yu Kuznetsova. "Subclinical vessel lesion in normotensive patients with abdominal obesity: focus on arterial stiffness." Systemic Hypertension 10, no. 2 (June 15, 2013): 46–52. http://dx.doi.org/10.26442/sg28967.
Повний текст джерелаАнотація:
Aim: assessment of arterial stiffness (AS) in patients with abdominal obesity (AO) without arterial hypertension and low cardio-vascular risk (CVR), the analysis of AS correlation with the markers of target organ remodeling, determination of threshold values AS, combined with a high probability target organ damage. Subjects and methods. 95 normotensive patients with AO were examined (mean age 44,9±5,1 years, 72 men) by following methods: lipid and glucose level, carotid artery ultrasound with intima/media thickness estimation, echocardiography, 24-hour monitoring of blood pressure (BP) with arterial stiffness assessment, obtained by the portable recorder BPLab. Results. Subclinical arterial lesion was revealed in 37,9%, mean pulse wave velocity (PWV) was 7,6±0,6 m/s, maximum PWV – 10 m/s. PWV and central BP in aorta were higher in patients with subclinical carotid atherosclerosis (8,0±0,5 m/s vs 7,5±0,6 m/s, р
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Sholy K Vareed, Don Paul Mathew, and P Suresh. "Carotid Artery Intimal Medial thickness in Diabetic and Non-Diabetic Subjects in Central Kerala." Asian Journal of Medical Radiological Research 8, no. 2 (December 31, 2020): 99–105. http://dx.doi.org/10.47009/ajmrr.2020.8.2.16.
Повний текст джерелаАнотація:
Background: Increase in intimal medial thickness (IMT) of the carotid arteries is contemplated as a guide to atherosclerotic vascular disease and subclinical organ damage and foretell cardiovascular disease. The study aimed to analyse IMT in non-diabetic and diabetic subjects. Subjects and Methods: There were 105 diabetic and 95 non-diabetic subjects in this study. Common carotid artery (CCA) IMT was calculated using a linear probe of a high-resolution ultrasound medical system. Results: Diabetic subjects (0.95 mm) showed significantly higher mean intimal medial thickness (IMT) when compared non-diabetic subjects (0.85 mm) (p <0.05). Correlation of IMT was seen with age, total cholesterol, triglycerides, HDL & LDL cholesterol and systolic blood pressure (SBP) in diabetic subjects. Total cholesterol, SBP and diastolic blood pressure (DBP) showed a correlation with IMT in the non-diabetic subjects. Age, total cholesterol, SBP, and diabetes were independent risk factors for intimal medial thickness in multivariate linear regression analysis. Conclusion: Higher intimal medial thickness was seen in diabetic subjects when compared to non-diabetic subjects. We conclude that age, total cholesterol, SBP and duration of diabetes showed a significant correlation with IMT. IMT can be considered as a screening tool in diabetic patients for the early detection of atherosclerosis.
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Mercurio, Lobasso, Barbieri, Parrella, Ciervo, Liccardo, Bonaduce, Tocchetti, De Paulis, and Rossi. "Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients." International Journal of Molecular Sciences 20, no. 9 (April 30, 2019): 2154. http://dx.doi.org/10.3390/ijms20092154.
Повний текст джерелаАнотація:
Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and clinical markers of SLE determine and correlate with arterial stiffness in SLE patients. Materials and methods: Routine blood samples, inflammatory mediators, specific antibodies, and 24 h proteinuria were measured in 43 SLE patients and 43 age and sex-matched controls using routine laboratory assays. We also assessed arterial stiffness by measuring radial artery applanation tonometry-derived augmentation index (AI), normalized AI (AIx@75), aortic pulse pressure, central systolic, diastolic and peripheral blood pressure. Results: SLE patients showed a significantly greater arterial stiffness vs. controls, as demonstrated by the significantly higher AIx@75 and aortic pulse pressure. Interestingly, regression analysis showed that age, systolic pulse pressure, inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), daily dose of glucocorticoids, and cumulative organ damage positively correlated with arterial stiffness. Conclusions: SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD.
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Maloberti, Alessandro, Francesca Farina, Marco Carbonaro, Enrico Piccinelli, Ilaria Bassi, Francesco Pansera, Guido Grassi, Giuseppe Mancia, Paola Palestini, and Cristina Giannattasio. "In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers." Blood Pressure 27, no. 5 (April 12, 2018): 262–70. http://dx.doi.org/10.1080/08037051.2018.1461010.
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Mancuso, Elettra, Maria Perticone, Rosangela Spiga, Carolina Averta, Mariangela Rubino, Teresa Vanessa Fiorentino, Sofia Miceli, et al. "Association between Serum Mg2+ Concentrations and Cardiovascular Organ Damage in a Cohort of Adult Subjects." Nutrients 12, no. 5 (April 29, 2020): 1264. http://dx.doi.org/10.3390/nu12051264.
Повний текст джерелаАнотація:
Magnesium (Mg2+) levels are associated with insulin resistance, hypertension, atherosclerosis, and type 2 diabetes (T2DM). We evaluated the clinical utility of physiological Mg2+ in assessing subclinical cardiovascular organ damage including increased carotid artery intima- media thickness (c-IMT) and left ventricular mass index (LVMI) in a cohort of well-characterized adult non-diabetic individuals. Age- and gender-adjusted correlations between Mg2+ and metabolic parameters showed that Mg2+ circulating levels were correlated negatively with body mass index (BMI), fasting glucose, and 2h-oral glucose tolerance test (OGTT) glucose. Similarly, Mg2+ levels were significantly and negatively related to c-IMT and LVMI. A multivariate regression analysis revealed that age (β = 0.440; p < 0.0001), BMI (β = 0.225; p < 0.0001), and Mg2+ concentration (β = −0.122; p < 0.01) were independently associated with c-IMT. Age (β = 0.244; p = 0.012), Mg2+ (β = −0.177; p = 0.019), and diastolic blood pressure (β = 0.184; p = 0.038) were significantly associated with LVMI in women, while age (β = 0.211; p = 0.019), Mg2+ (β = −0.171; p = 0.038) and the homeostasis model assessment index of insulin resistance (HOMA-IR) (β = −0.211; p = 0.041) were the sole variables associated with LVMI in men. In conclusion, our data support the hypothesis that the assessment of Mg2+ as part of the initial work-up might help unravel the presence of subclinical organ damage in subjects at increased risk of cardiovascular complications.
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Kim, Darae, Chi Young Shim, Geu-Ru Hong, In Jeong Cho, Hyuk-Jae Chang, Jong-Won Ha, and Namsik Chung. "IMPLICATION OF NIGHT-TIME MEAN SYSTOLIC BLOOD PRESSURE FOR PREDICTING SUBCLINICAL TARGET ORGAN DAMAGE IN HYPERTENSION: COMPARISON WITH OFFICE CENTRAL BLOOD PRESSURES." Journal of the American College of Cardiology 67, no. 13 (April 2016): 1879. http://dx.doi.org/10.1016/s0735-1097(16)31880-0.
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Wan, Jindong, Gang Liu, Siwei Xia, Sen Liu, Yi Yang, Dan Wang, Jixin Hou, Xiaozhen Dai, Peng Zhou, and Peijian Wang. "Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults." Therapeutic Advances in Chronic Disease 13 (January 2022): 204062232211350. http://dx.doi.org/10.1177/20406223221135011.
Повний текст джерелаАнотація:
Background: Hypertension-mediated organ damage (HMOD) is an emerging problem among young adults. The potential role of chronic immune-mediated inflammation in the pathogenesis of HMOD is increasingly being recognized. High-mobility group box 2 (HMGB2) is known for its role in the modulation of innate immunity and exerts signaling functions that affect various inflammatory diseases. However, the association between HMGB2 and HMOD in young adults remains unclear. Objectives: The aim of this study was to explore the association between HMGB2 and subclinical HMOD in young adults. Design: This is a cross-sectional study. Methods: Body composition, carotid ultrasound, carotid-femoral PWV (cf-PWV) measures, echocardiography, serum HMGB2 levels, and serum classic cardiometabolic risk factors were measured in 988 untreated young adults. We estimated the risk related to serum HMGB2 using multivariable-adjusted linear and logistic regression models. Then, we conducted a pathway overrepresentation analysis to examine which key biological pathways may be linked to serum HMGB2 in young adults with HMOD. Results: Among the 988 untreated young adults, we identified four distinct hypertension phenotypes: normotension (40.0%), white-coat hypertension (16.0%), masked hypertension (20.9%), and sustained hypertension (23.1%). High levels of serum HMGB2 were related to increased carotid intima-media thickness (cIMT) and left ventricular mass index (LVMI), higher cf-PWV and blood pressure, and a lower estimated glomerular filtration rate (eGFR). Linear regression analysis showed that serum HMGB2 was positively associated with cf-PWV and negatively associated with eGFR in all patients. Multivariate analysis showed that high levels of serum HMGB2 were associated with high odds of subclinical HMOD (damage in at least one organ). Biological pathway analysis indicated that patients with high serum HMGB2 levels had increased activity of pathways, related to endothelial dysfunction, inflammatory processes, and atherosclerosis. Conclusion: High serum concentrations of HMGB2 are associated with an increased risk of subclinical HMOD in untreated young adults.
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Rogowska, Anna, Łukasz Obrycki, Zbigniew Kułaga, Claudia Kowalewska, and Mieczysław Litwin. "Remodeling of Retinal Microcirculation Is Associated With Subclinical Arterial Injury in Hypertensive Children." Hypertension 77, no. 4 (April 2021): 1203–11. http://dx.doi.org/10.1161/hypertensionaha.120.16734.
Повний текст джерелаАнотація:
The aim of the study was to assess the relationship between hypertensive target organ damage and vessel density (VD), foveal thickness, thickness of retinal nerve fiber layer, ganglion cell complex, and foveal avascular zone (FAZ) using optical coherence tomography angiography in a nonselected group of hypertensive children. One hundred fifty-seven children (56 girls) in mean age 14.9±2.9 years, in whom arterial hypertension was ultimately diagnosed were included in the study. FAZ, whole, fovea, parafovea superficial VD, whole, fovea, parafovea deep VD, foveal thickness, retinal nerve fiber layer, and ganglion cell complex were taken into analysis. Both absolute and standardized values of carotid intima-media thickness correlated with the larger FAZ area ( P =0.035, r =0.17; P =0.01, r =0.2, respectively). Subjects with increased carotid intima-media thickness had significantly larger FAZ ( P =0.024), reduced fovea superficial VD ( P =0.039), and foveal thickness ( P =0.007). Left ventricular hypertrophy and increased carotid-femoral pulse wave velocity were not associated with optical coherence tomography angiography parameters. Multiple linear regression revealed that the only determinant of FAZ and foveal thickness was higher carotid intima-media thickness–SD score, and for fovea superficial VD, the only determinant was central systolic blood pressure. In conclusion, hypertensive children present with signs of remodeling of microcirculation and decreased neural layer of retina associated with hypertensive macrocirculation remodeling expressed as increased carotid intima-media thickness and elevated central systolic blood pressure.
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Iureva, T. N., and A. A. Zaika. "The concept of comorbidity of dyscirculatory encephalopathy and vascular optical neuropathy (literature review)." Acta Biomedica Scientifica 7, no. 6 (December 29, 2022): 181–93. http://dx.doi.org/10.29413/abs.2022-7.6.18.
Повний текст джерелаАнотація:
The analysis of literature data on ischemic damage to the brain and the organ of vision was carried out in order to study etiological factors, pathogenetic processes, parallel flow and mutual influence of two nosological forms: dyscirculatory encephalopathy and vascular optic neuropathy. According to the World Health Organization, there is much more people suffering from cardiovascular diseases: atherosclerosis, hypertension, diabetes mellitus and coronary heart disease. These diseases result in ischemic damage to a number of vital organs, including the central nervous system and the visual analyzer. Chronic vascular pathology of both the brain and the eye is one of the leading causes of patients’ life quality decrease of and their disability. The “triggering” causes of brain and eye damage, according to researchers, are cerebral atherosclerosis, elevating/fluctuating blood pressure, coronary heart disease, and carbohydrate metabolism disorders. Disorders of the systemic blood supply caused by these etiological factors lead to a progressive lack of oxygen supply to organs and tissues, followed by the development of intracellular and cellular hypoxia, and an ischemic intracellular cascade of biochemical disorders leading to dysfunction and sometimes cell death.In addition to direct hypoxic-ischemic damage of the nervous and visual systems cells, endothelial dysfunction contributes to the progression of these diseases, leading to a pronounced change in the wall at the level of small vessels, a change in its reactivity and a violation of the coagulation properties of blood, and as a consequence, to a gradual accumulation of ischemic and secondary degenerative changes in brain and eye cells.Knowledge of etiological factors and patterns of development of brain and eye combined ischemic damage can allow clarifying the complex of diagnostic measures, developing preventive measures, as well as prescribe pathogenetically justified treatment of existing pathology.
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Marčun Varda, Nataša, and Mirjam Močnik. "Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children." Kidney and Blood Pressure Research 47, no. 1 (October 15, 2021): 43–49. http://dx.doi.org/10.1159/000519340.
Повний текст джерелаАнотація:
<b><i>Objectives:</i></b> Chronic kidney disease (CKD) is a well-established risk factor for cardiovascular diseases. Studies in adults have demonstrated the association between mildly decreased kidney function or even normal values of markers of kidney function to pulse wave velocity (PWV), a measure of arterial stiffness and a predictor of cardiovascular events. Our study aimed to evaluate associations between markers of CKD, PWV, and central haemodynamic parameters in children and adolescents at risk of subclinical kidney damage. <b><i>Methods:</i></b> 182 children and adolescents with hypertension, obesity, or hypercholesterolaemia (risk factors for subclinical kidney damage) were included in the study. The subjects were subdivided into 4 groups comprising children and adolescents with hypertension (group 1), obesity (group 2), hypercholesterolaemia (group 3), and a group with a combination of risk factors, such as obesity-related hypertension and metabolic syndrome (group 4). The study groups were compared to a group of healthy controls (group 5). PWV was measured by applanation tonometry (SphygmoCor, SCOR-Vx, Sydney, NSW, Australia) and laboratory parameters (serum creatinine, serum cystatin C, and microalbuminuria) were collected. <b><i>Results:</i></b> Pearson’s correlation coefficient demonstrated a statistically significant correlation between PWV and serum creatinine in group of all subjects (<i>r</i> = 0.220, <i>p</i> = 0.002). Further subdivision showed the correlation was significant in group 4 (<i>r</i> = 0.370, <i>p</i> = 0.002). In group 2 a correlation between PWV and cystatin C was found (<i>r</i> = −0.535, <i>p</i> = 0.009). In multiple regression analysis of all subjects with PWV as the dependent variable, age and diastolic blood pressure were statistically significant. Correlations between markers of kidney function and central haemodynamic parameters also showed significant correlations between serum creatinine and heart rate (HR) (<i>r</i> = −0.476, <i>p</i> < 0.001) as well as associated parameters (augmentation index, standardized at HR 75/min, ejection duration, and subendocardial viability ratio). <b><i>Conclusions:</i></b> Our study demonstrated a correlation between serum creatinine and PWV in children with combined risk factors for atherosclerosis and probable subclinical kidney damage. Further prospective research is needed to confirm the findings, and thus the preventive role of PWV determination in paediatric nephrology.
Дисертації з теми "Central blood pressure, atherosclerosis, subclinical organ damage"
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Tagetti, Angela. "EARLY PREDICTION OF SUBCLINICAL VASCULAR DAMAGE IN RISKY POPULATIONS." Doctoral thesis, 2022. http://hdl.handle.net/11562/1062695.
Повний текст джерелаАнотація:
Background. Atherosclerosis is a progressive disease that starts during adoles-cence and exerts its negative effects later in life. High blood pressure is one of the principal risk factors for cardiovascular disease. Central blood pressure is the pressure that directly insists and other major arteries and is linked to target organ damage and cardiovascular events. The aim of the thesis was to assess the role of traditional and novel risk factors (central blood pressure, cBP) on children and adolescents with type I diabetes (T1D; study number 1) and in children and ado-lescents with solitary functional kidney (SFK; study n.2). Methods. Carotid intima-media thickness (cIMT), carotid distensibility coeffi-cient (cDC), and carotid-femoral pulse wave velocity (PWV), were measured in children and adolescents with T1D and SFK. Blood Pressure (BP; both central and peripheral), echocardiographic measurements, biochemical data from blood and urine sample and other cardiovascular risk factors were evaluated in multi-variate linear regressions to assess the association with the measured indices of subclinical vascular damage. Results study 1. One hundred and twenty-six children and adolescents with T1D were included. cIMT was above the 95th percentile for age and height in 61% of the population. Bivariate correlations showed that cBP but not peripheral blood pressure (pBP) were positively associated with cIMT (r = 0.285; p = 0.001). In-dependent determinants of cIMT according to the regression models were only gender, type of glucose monitoring and central systolic BP (cSBP). PWV was as-sociated with age, sex, heart rate, and cSBP; cDC with age and both cSBP, and, alternatively, peripheral BP (pBP). Neither pBP nor any of the tested metabolic parameters, including glycated hemoglobin, were associated with PWV and cIMT. Results study 2. 48 SFK children and adolescents were included. Of them 50% had increased cIMT. cBP was correlated with all vascular indices measured and with the left ventricular mass (r = 0.417; p = 0.005) but not with RWT. pBP cor-related with distensibility, with PWV and with the LVMi. Daytime systolic blood pressure was found to be associated with all vascular indices but not with echo-cardiographic ones. BMI correlated with the variables indicative of organ dam-age and with many pressure variables. No correlation was found between the vas-cular or echocardiographic indices and either estimated glomerulaf filtration rate or urinary albumin to creatinine ratio. In linear regression pBP were not associat-ed with the above-mentioned vascular variables whereas cBP was positively as-sociated with cIMT (even when we consider z-score values). To the contrary, cDC and PWV were not associated with cBP. In binary logistic regression analy-sis, cBP was a predictor for increased cIMT. Conclusions: Taken together, our data show a high prevalence of increased cIMT in children and adolescents with T1D and SFK. cBP more than pBP or other tra-ditional risk factors associates with subclinical organ damage.
Частини книг з теми "Central blood pressure, atherosclerosis, subclinical organ damage"
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Erbel, Raimund, Nils Lehmann, Andreas Stang, Sofia Churzidse, Susanne Moebus, and Karl-Heinz Jöckel. "Blood Pressure and Atherosclerosis: Subclinical Arteriosclerosis as an Early Sign of Organ Damage." In Updates in Hypertension and Cardiovascular Protection, 363–81. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-75310-2_26.
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