Дисертації з теми "Cellular signals"
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Manktelow, Emily Frances. "Structural studies of viral and cellular recoding signals." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611943.
Повний текст джерелаPapaioannou, Alexandra. "Fine-tuning UPR signals and subsequent cellular outputs." Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1B013.
Повний текст джерелаThe present thesis explores the world of ER (endoplasmic reticulum) stress biology. A global view of ER and ER stress is first provided with a transition from the basic mechanisms involved to possible clinical applications. The focus is then placed to the crucial role of the UPR in carcinogenesis that is activated in response to ER stress in the micro-environment of the tumor. After reviewing these aspects, we point to missing parts in our comprehension of how UPR signals are fine-tuned and lead to either restoration of ER and cell homeostasis or cell death. Among the UPR branches, ATF6 and IRE1 signaling become our focus of investigation because of their convergence in the regulation of the pro-survival factor XBP1s. On the one hand, we unravel mechanisms originating from the ER lumen that regulate the ATF6 activation in response to ER stress and affect its downstream cell adaptive signaling. On the other hand, we witness the existence of an auto-regulatory network of IRE1 RNase activity consisted of a tyrosine kinase-phosphatase system that targets RtcB and impacts on XBP1 mRNA splicing. Hence, through our studies we uncover an integrated signaling circuit that can fine-tune the cellular outputs of the joint ATF6 and IRE1 activation in response to ER stress
Thomson, Ty M., and Drew Endy. "Rapid Characterization of Cellular Pathways Using Time-Varying Signals." International Conference on Systems Biology, 2005. http://hdl.handle.net/1721.1/29803.
Повний текст джерелаPoster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA.
Madhavan, Shashi D. "Biomechanical signals mediate cellular mechano-transduction and gene regulation." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195234773.
Повний текст джерелаBrandman, Onn. "Feedback loops shape cellular signals in space and time /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Повний текст джерелаOsuna, José A. "The recognition of acoustical alarm signals with cellular neural networks /." [S.l.] : [s.n.], 1995. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11058.
Повний текст джерелаWong, Stephanie A. "Physical and Molecular Pathways Involved in Cellular Sensing of Mechanical Signals." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/878.
Повний текст джерелаLau, See-yan. "A study of intracellular signals of K-opioids in non-neuronal cells /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19667139.
Повний текст джерелаPark, Edward S. "Microfluidic chamber arrays for testing cellular responses to soluble-matrix and gradient signals." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39471.
Повний текст джерелаHeessen, Stijn. "Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-600-6/.
Повний текст джерелаFong, Lai-ping Iris, and 方麗萍. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971015.
Повний текст джерела劉思恩 and See-yan Lau. "A study of intracellular signals of K-opioids in non-neuronal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31214290.
Повний текст джерелаBOAVENTURA, ALBERTO MAGNO SILVEIRA. "EVALUATION OF ESTIMATION METHODS OF DIRECTION OF ARRIVAL OF SIGNALS IN CELLULAR COMMUNICATIONS SYSTEMS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 1998. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=7529@1.
Повний текст джерелаEste estudo tem por objetivo contribuir para emprego de antenas adaptativas em sistemas de comunicação sem fio. É feita uma revisão dos métodos de estimação de ângulo de chegada e de sua utilização na formação de feixe. O desempenho de alguns métodos baseados em subspace fitting é comparado através de simulação considerando quatro cenários. O primeiro supões apenas a presença de ruído. Os demais consideram os modelos típicos de espalhamento local, ou seja, espalhamento aleatório dos ângulos de chegada.
This work intends to contribute for the employment of the Adaptive Antennas in Wireless Communications. In this way, a review of methods for direction of arrival estimation and beamforming is presented. The performance of some subspace fitting direction of arrival estimation methods is evaluated by simulation considering four propagation scenarios: The first assumes only additive white Gaussian noise; The three others consider typical models for local scattering, which means a random angular spread of angle of arrival.
Ma, Leung Hang. "Characterization of calcium signals during the blastula period of zebrafish (danio rerio) embryogenesis /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202007%20MA.
Повний текст джерелаFong, Lai-ping Iris. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971015.
Повний текст джерелаLeitao, Beatriz Belchior. "The role of the SUMO pathway in the cellular responses to oxidative stress signals in human endometrium." Thesis, Imperial College London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544293.
Повний текст джерелаDumond, Mathilde. "From cellular variability to shape reproducibility : mechanics and morphogenesis of Arabidopsis thaliana sepal." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN047/document.
Повний текст джерелаDevelopmental robustness is the ability to produce similar phenotypes despite intrinsic variability.Regulation of organ shape has been widely studied, but regulation of organ shape reproducibility is yet to be elucidated.A. thaliana sepals, flower external organs, can be used to study such robustness : each plant produces more than 60 flowers, allowing variability measurement.Plant cells modulate their surrounding cell wall stiffness and anisotropy to control growth, thus my PhD aims at elucidating the role of cell wall mechanics on organ shape robustness.Cells sense their physical environment and accordingly adjust their cell wall mechanics: we studied whether the strength of this feedback influenced organ shapes. Using a model, I showed that a strong feedback lead to the formation of a pointy sepal tip; this prediction was experimentally validated by a PhD student of the team.Measurements of the cell wall mechanical properties using atomic force microscopy (AFM) showed that they were highly spatially variable. When this variability was added in the model, the organ shapes were variable. To get reproducible shapes, I increased the temporal variability of the mechanics: it smoothed the spatial variability over time. Likewise, decreasing spatial variability reduced organ shape robustness. These theoretical results suggest that spatial and temporal variability influence shape robustness.To experimentally test these results, our collaborators identified a mutant displaying less robust sepal shapes. Using AFM, I showed that the spatial variability was reduced in the mutant, confirming that mechanical spatial variability influenced shape robustness
Bhrigu, Gargi. "Sorting Signals, Domain Conformation and Interdomain Interactions in CFTR Misprocessing and Rescue." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1268659408.
Повний текст джерелаLira, Junior Mario de Andrade. "Environmental factors and plant-to-bacteria signals effects on nodulation and nodule development of pea." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38075.
Повний текст джерелаMouradi, Rand. "Wireless Signals and Male Fertility." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1318571631.
Повний текст джерелаHuang, Yun. "Integration of Extracellular and Intracellular Calcium Signals: Roles of Calcium-Sensing Receptor (CASR), Calmodulin and Stromal Interaction Molecule 1 (STIM1)." Atlanta, Ga. : Georgia State University, 2008. http://digitalarchive.gsu.edu/chemistry_diss/28/.
Повний текст джерелаTitle from title page (Digital Archive@GSU, viewed July 1, 2010) Jenny J. Yang, committee chair; Edward Brown, Giovanni Gadda, Zhi-ren Liu, committee members. Includes bibliographical references (p. 230-258).
Coronato, Nicola [Verfasser], Paul Gottlob [Akademischer Betreuer] Layer, and Bodo [Akademischer Betreuer] Laube. "Identification of cellular and molecular signals involved in neural retina specification in the developing chick embryo / Nicola Coronato ; Paul Gottlob Layer, Bodo Laube." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2017. http://d-nb.info/1137624752/34.
Повний текст джерелаKhattar, Mithun. "Modulation of TCR Signals Reprograms Immune Tolerance in Transplantation and Type-1 Diabetes." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1329231545.
Повний текст джерелаMoskalenko, Bogdan, and Богдан Дмитрович Москаленко. "Temperatures influence of nanocircuits." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50365.
Повний текст джерелаThe purpose of this article was to prove that the main element (ME) together with the inverter, ie the universal ME, is a functionally complete element base of one-electron nanochemistry. During the simulations of the element operation, it was proved that the temperature directly affects the operation of logic nanoschemas on cellular machines that use most elements. Therefore, research and modeling of their effectiveness is an urgent task.
Метою даної статті було довести, що основний елемент (МЕ) разом з інвертором, тобто універсальний МЕ, є функціонально повною елементною базою одноелектронної нанохімії. Під час симуляцій роботи елементу було доведено що температура безпосередньо впливає на роботу логічних наносхем на квантових автоматах, що використовують більшість елементів. Тому дослідження та моделювання їх ефективності - актуальне завдання.
Ruppert, Shannon Moore. "Signals Delivered By Interleukin-7 Regulate The Activities Of Bim And JunD In T Lymphocytes." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5475.
Повний текст джерелаID: 031001292; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Error in paging: p. v followed by 1 unnumbered page and then followed by p. ii-vii.; Adviser: Annette R. Khaled.; Title from PDF title page (viewed March 1, 2013).; Thesis (Ph.D.)--University of Central Florida, 2012.; Includes bibliographical references (p. 99-121).
Ph.D.
Doctorate
Molecular Biology and Microbiology
Medicine
Biomedical Sciences
Song, Hao. "Hematopoietic cell lineage switching mediated by zebrafish STAT1B." Thesis, University of Oregon, 2010. http://hdl.handle.net/1794/10913.
Повний текст джерелаA critical question for developmental biology is the mechanism by which cells make fate decisions. In the hematopoietic system, stem cells differentiate into several different cell types, but the mechanisms that affect this process are incompletely known. Understanding these mechanisms is important because abnormal regulation of hematopoiesis can result in disease. STAT1 protein plays crucial roles in mediating innate immunity by transducing interferon signals, but recent results have also related STAT1 to hematopoietic cell differentiation. Here we cloned a previously uncharacterized zebrafish co-ortholog of the human STAT1 gene we call stat1b and investigated the functions of two zebrafish Stat1 proteins in hematopoiesis. The advantage of the zebrafish model is that, due to a whole genome duplication (WGD), some human genes have two co-orthologs in zebrafish. During evolution, co-orthologs have retained or acquired similar, complimentary, or new functions. Both stat1a and stat1b encode all four characteristic domains of the human STAT1 protein. Phylogenetic and conserved synteny analyses showed that stat1b and stat1a arose as duplicates in the teleost genome duplication event, and these analyses clarified the historical origin of the entire vertebrate STAT gene family. RT-PCR demonstrated maternal expression of both stat1a and stat1b . Expression of stat1b, but not stat1a, was detected in hematopoietic domains of embryos by in situ hybridization. Morpholino knockdown of stat1b , but not stat1a, mRNA expression resulted in a decrease in expression of the myeloid cell marker genes spi and mpx and an increase in expression of the hematopoietic progenitor marker gene scl and the erythrocyte marker gene gatal. These results show that in zebrafish, Stat1b protein functions in the commitment of hematopoietic cells to a myeloid cell fate.
Committee in charge: William Cresko, Chairperson, Biology; John Postlethwait, Advisor, Biology; Judith Eisen, Member, Biology; Jan Spitsbergen, Member, Not from U of O; J. Andrew Berglund, Outside Member, Chemistry
Ogese, Monday. "Definition of antigenic determinants in drug hypersensitive patients : an integrated clinical, chemical and cellular approach to quantify and characterize the drug signals presented to T-Lymphocytes." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/18733/.
Повний текст джерелаHempel, Felix [Verfasser], and Markus [Akademischer Betreuer] Hoth. "Organic electrochemical transistors based on PEDOT : PSS for the sensing of cellular signals from confluent cell layers down to single cells / Felix Wolfgang Hempel ; Betreuer: Markus Hoth." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1212433653/34.
Повний текст джерелаHempel, Felix Wolfgang [Verfasser], and Markus [Akademischer Betreuer] Hoth. "Organic electrochemical transistors based on PEDOT : PSS for the sensing of cellular signals from confluent cell layers down to single cells / Felix Wolfgang Hempel ; Betreuer: Markus Hoth." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1212433653/34.
Повний текст джерелаLavik, Andrew R. "The Role of Inositol 1,4,5-Trisphosphate Receptor-Interacting Proteins in Regulating Inositol 1,4,5-Trisphosphate Receptor-Dependent Calcium Signals and Cell Survival." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448532307.
Повний текст джерелаRong, Yiping. "Bcl-2 Regulates Proapoptotic Calcium Signals by Interacting with the Inositol 1, 4, 5-Trisphosphate Receptor." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1228322705.
Повний текст джерелаBiver, Galadrielle. "Identification and characterization of the control of murine MSC differentiation by the ADP receptors P2Y12 and P2Y13." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209334.
Повний текст джерелаTo determine the physiological roles of P2Y receptor family, our laboratory generated different strains of P2Y knockout mice (P2Y4 ,6 and 13). In collaboration with A. Gartland ,I. And Arnett TR Orriss ( Sheffield and London University) ,it has been observed that the P2Y13R-/- mice exhibit an impaired bone tissue metabolism that leads to a reduction in the volume of the femoral trabecular bone and the number of trabeculae. This phenotype is correlated with the decrease in the number of osteoblasts at the endo-cortical bone surface .
We therefore examined whether P2Y13 R activation was involved in the osteogenic differentiation of mesenchymal stem cells (MSCs). In the first part of our work we have shown that :
Induction of the MSCs differentiation is associated with the release of ATP and its conversion to ADP (agonist of the P2Y13R). ATP release probably involves the pannexine1 while the conversion of ATP into ADP is probably due to the activity of the ecto-nucleotidase CD39L1.
ADP stimulation of P2Y13 R+/+ (but not P2Y13 R-/-) adherent bone marrow stromal cells (BMSC) increased significantly the formation of alkaline phosphatase-colony forming units (CFU-ALP), as well as the expression of osteoblastic genes such as Osterix involved in the maturation of pre-osteoblasts into osteoblasts. The number of CFU-ALP obtained from P2Y13 R-/- BMSC and the level of osteoblastic gene expression after osteogenic stimulation were also strongly reduced compared to those obtained in wild-type cell cultures. In contrast, when P2Y13 R-/- BMSCs were incubated in an adipogenic medium, the number of adipocytes generated and the level of adipogenic gene expression (PPARγ2 and Adipsin) were higher than those obtained in P2Y13 R+/+ MSC. We also observed a significant increase of the number of bone marrow adipocytes in tibia of P2Y13 R-/- mice.
The P2ry12 gene deletion (also activated by ADP) also affects the ability of BMSCs to differentiate into osteoblasts but stimulates adipogenic differentiation.
In a second part of our work ,we have shown that the pro- osteogenic action of P2Y13R is indirect. Indeed ,this receptor is not expressed by MSCs but by adherent myeloid cells present in the bone marrow cell cultures (characterized by the expression of CD11b and CD45 markers) .In addition, we observed that following receptor activation by ADP ,these myeloid cells produce BMP2 factor.
We therefor propose that the stimulation of MSCs differentiation induces CD45- adherent cells to release ATP that is converted into ADP, most probably by the up-regulated CD39L1 ectonucleotidase. This ADP stimulates P2Y12R and P2Y13R expressed by CD45+/CD11b+ myeloid cells leading to the release of the osteogenic factor BMP2. This cytokine favours the maturation of pre-osteoblasts into osteoblasts and concomitantly inhibits the maturation of pre-adipocytes.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Hennig, Katharina. "Dynamique des forces motiles et brisure de symétrie chez la cellule migrante." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAY040/document.
Повний текст джерелаDirectional cell motility during organism and tissue development, homeostasis and disease requires symmetry breaking. This process relies on the ability of single cells to establish a front-rear polarity, and can occur in absence of external cues. The initiation of migration has been attributed to the spontaneous polarization of cytoskeleton components, while the spatio- temporal evolution of cytoskeletal forces arising from continuous mechanical cell-substrate interaction has yet to be resolved. Here, we establish a one- dimensional microfabricated migration assay that mimics complex in vivo fibrillar environment while being compatible with high-resolution force measurements, quantitative microscopy, and optogenetics. Quantification of morphometric and mechanical parameters reveals a generic stick-slip behavior initiated by contractility-dependent stochastic detachment of adhesive contacts at one side of the cell, which is sufficient to drive directional cell motility in absence of pre-established cytoskeleton polarity or morphogen gradients. A theoretical model validates the crucial role of adhesion dynamics during spontaneous symmetry breaking, proposing that the examined phenomenon can emerge independently of a complex self-polarizing system
Pinidiyaarachchi, Amalka. "Digital Image Analysis of Cells : Applications in 2D, 3D and Time." Doctoral thesis, Uppsala universitet, Centrum för bildanalys, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9541.
Повний текст джерелаMasri, Bernard. "Fonction endothéliale du récepteur de l'apeline : étude de la cascade de transduction et implications physiologiques." Toulouse 3, 2004. http://www.theses.fr/2004TOU30181.
Повний текст джерелаOur team have characterized a new receptor, msr/apj, which is expressed in the endothelium of newly forming heart and blood vessels. In 1998, the endogenous ligand (named apeline) of this receptor was isolated by a Japanese laboratory. In order to understand the endothelial function of this new signaling pathway, we analyzed the various signal transduction pathways activated by apelin in CHO cells which stably express msr/apj. In these cells, apelin induces inhibition of adenylylcyclase, and activation of ERKs and p70S6 kinase. The stable expression of pertussis toxin insensitive a subunits of G proteins led us to demonstrate that ERK stimulation is ai2 dependent and Ras independent. The p70S6 kinase stimulation preferentially involves ai1, a PI3 Kinase, Akt, and mTOR. Interestingly, we observed that HUVEC (Human Umbilical Vein Endothelial Cells) endogenously express the apelin receptor. In these cells, apelin induces the activation of p70S6K and leads to their proliferation. However, these cells also express apelin which can induce an autocrine desensitization of the receptor. This desensitization can be obtained after acute pretreatment of the CHO by apelin or observed with CHO cells co-expressing the receptor and apelin. The deletion of the receptor C-terminal domain abolishes the desensitization associated with the coupling with the ai2 subunit and the ERK activation. Thus, this receptor represents a new pharmacological target for pathologies associated with a neovascularization such as the solid tumors development and ischemic retinopathy
L'Allemain, Gilles. "Mécanisme d'action des facteurs de croissance : étude des évènements précoces dans la transmission du signal mitogénique." Nice, 1986. http://www.theses.fr/1986NICE4047.
Повний текст джерелаHaugh, Jason Michael 1972. "Cellular compartmentation effects in receptor-mediated signal transduction." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85364.
Повний текст джерелаLeahy, Rachel A. "Signal Transduction and Cellular Differentiation in Airway Epithelium." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1352673026.
Повний текст джерелаJouaville, Laurence Sophie. "Modulation mitochondriale des signaux calciques intracellulaires." Bordeaux 2, 1996. http://www.theses.fr/1996BOR28441.
Повний текст джерелаGammon, Benjamin Matthew. "Signal transduction in the cellular slime mould Dictyostelium discoideum." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279872.
Повний текст джерелаNajari, Moghadam Nima. "On Multiantenna Cellular Communications: From Theory to Practice." Doctoral thesis, KTH, Teknisk informationsvetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207623.
Повний текст джерелаQC 20170523
Radnosrati, Kamiar. "On Timing-Based Localization in Cellular Radio Networks." Licentiate thesis, Linköpings universitet, Reglerteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148074.
Повний текст джерелаPat, Betty Kila. "Signal transduction pathways in renal fibrosis /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17739.pdf.
Повний текст джерелаChang, Wen-Tsan. "Molecular studies of signal transduction and development." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360212.
Повний текст джерелаMoulager, Mickael. "Intégration séquentielle des signaux métaboliques et circadiens dans le contrôle de la division cellulaire d'Ostreococcus tauri." Perpignan, 2008. http://www.theses.fr/2008PERP0874.
Повний текст джерелаCircadian clock and metabolic status are two cellular parameters controlling a lot of processes. Better understand input pathways of these two parameters are critical for knowledge of cell division regulation. In the picoeucaryote Ostreococcus tauri, these controls occur in a sequential way along G1. Molecular dissection of the metabolic control was performed
Chasseriau, Jacques. "Coopération entre Bcr-Abl et p95vav pour l'induction de la mobilité cellulaire médiée par les GTPases de la famille Rho." Poitiers, 2006. http://www.theses.fr/2006POIT2302.
Повний текст джерелаThe chimerical oncogene BCR-ABL is known to induce autonomous motility of leukemic cells. We previously showed that p210bcr-abl responsible for chronic myelogenous leukaemia activates RhoA and Rac1, while p190bcr-abl, associated with acute lymphoid leukaemia, although devoid of a DH domain activates Rac1, but not RhoA. Moreover p95vav is present in an activated state in complex with Bcr-Abl. Here, we investigated the regulation of GEF activities in the BCR-ABL complex. For that purpose, different GEF activity mutants of Vav and of BCR-ABL were constructed and stably transfected in Ba/F3 cells. We demonstrated that RhoA is exclusively activated by the DH domain of p210bcr-abl, while Rac1 activation was only due to Vav. We show that p210bcr-abl induces a specific amoeboid mobility which is due to RhoA activity, while p190bcr-abl induces a rolling type mobility associated with Rac1 activity. Finally, our results reveal a synergistic mechanism between BCR-ABL and Vav GEFs. Moreover, we demonstrated the presence of Vav2 and GTPase RhoG in the complex with Bcr-Abl. This new signaling pathway cooperates with Vav to activate Rac1 and probably Cdc42. Recently, using blood patient samples, we proved that our model of differential activation of Rho GTPases in leukemia disease is valid. We proposed a molecular study to follow up the leukemia diseases of patients
Rogers, Laura Ann. "Membranes as a hub for cellular signaling /." Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1481668281&sid=2&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаKim, Hyun Ji. "Development and signal transduction in Dictyostelium." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4ed80c6e-adc8-46d6-aeaf-c853cef7af77.
Повний текст джерелаHarding, Angus Silas. "A biochemical analysis of the MAP kinase pathway in mammalian cells /." A biochemical analysis of the MAP kinase pathway in mammalian cellsRead the abstract of the thesis, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17885.pdf.
Повний текст джерелаGrandbarbe, Luc. "Rôle de la voie de signalisation Notch dans la différenciation des cellules souches neurales." Université Louis Pasteur (Strasbourg) (1971-2008), 2002. http://www.theses.fr/2002STR13050.
Повний текст джерелаThe central nervous system comprises three major cell types: neurons, oligodendrocytes and astrocytes. All these cell-types derive from a common multipotential precursor cell, capable of self-renewing, and which is referred to as a neural stem cell. To elucidate the role of Notch signaling on the generation of neurons and glia, we made use of the in vitro neurosphère system which is clonally derived from neural stem cells through the selective action of EGF. Neurospheres prepared from Dll1lacZ mutant embryos display an increase of neurons at the expense of both oligodendrocytes and astrocytes. This mutant phenotype could be rescued when Dll1lacZ spheres were grown and/or differentiated in the presence of WT neurospheres conditioned medium. Time-dependant activation of Notch by soluble forms of ligands indicates that Notch acts in two steps. Initially, it acts on the cell fate choice by negatively regulating the neuronal fate and promoting the glial cell fate. In a second step, Notch promotes differentiation of astrocytes and inhibits differentiation of both neurons and oligodendrocytes