Дисертації з теми "Cell and Molecular Bioscience"
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Sargeant, Timothy John. "The effect of opiates on developing cerebral cortex : a thesis submitted to the Victoria University of Wellington in fulfilment of the requirements for the degree of Doctor of Philosophy in Cell and Molecular Bioscience /." ResearchArchive@Victoria e-Thesis, 2008. http://hdl.handle.net/10063/414.
Повний текст джерелаReader, Karen Lee. "A quantitative ultrastructural study of oocytes during the early stages of ovarian follicular development in Booroola and wild-type sheep : a thesis submitted to the Victoria University of Wellington in fulfilment of the requirements for the degree of Master of Science in Cell and Molecular Bioscience /." ResearchArchive@Victoria e-Thesis, 2007. http://hdl.handle.net/10063/270.
Повний текст джерелаSpeh, Michel Jonathan. "Transcriptional changes in stem cell-derived cardiomyocytes during extended cell cultures." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18781.
Повний текст джерелаPatel, Angana Heet. "Unravelingthe molecular mechanism behind metabolic reprogramming caused by alterations of the enzyme PI3-kinase." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17410.
Повний текст джерелаBabena, Omar. "Expression of the chloride channel CLCC1 is downregulated after 24 hours in LPS-primed THP-1 monocyte-like cell line." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20377.
Повний текст джерелаHolscher, Maxwell Arthur. "Molecular analysis of NK cell - target cell interactions." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287147.
Повний текст джерелаZannettino, Andrew Christopher William. "Molecular definition of stromal cell-stem cell interactions /." Title page, contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phz32.pdf.
Повний текст джерелаBair, Elisabeth Laurine. "Cell-cell and cell-matrix interactions involved in cancer invasion." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280673.
Повний текст джерелаLee, Soo Young. "Dissecting Molecular Mechanisms of Shigella flexneri Cell-to-cell Spread." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065011.
Повний текст джерелаRennel, Emma. "Molecular Mechanisms in Endothelial Cell Differentiation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4059.
Повний текст джерелаMasciarelli, Silvia. "Molecular physiology of plasma cell differentiation." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491475.
Повний текст джерелаClements, Sarah L. "Molecular studies of Guard Cell Function." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521890.
Повний текст джерелаEdwards, T. L. "The molecular cell biology of spartin." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598783.
Повний текст джерелаYaacob, Nik Soriani. "Molecular cell biology of peroxisome proliferators." Thesis, University of Surrey, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244831.
Повний текст джерелаSchnyder, T. "Molecular mechanisms of B cell activation." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1379268/.
Повний текст джерелаHalldorsson, Steinar. "Molecular determinants of phleboviral cell entry." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:56c5ef37-b023-4a8f-bdf2-8388226dc3b3.
Повний текст джерелаFeige, Peter. "Molecular Regulation of Satellite Cell Fate." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40804.
Повний текст джерелаHarrington, Elizabeth Anne. "Analysis of the molecular regulation of cell proliferation and cell death." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283286.
Повний текст джерелаLaw, Bic-fai Fian. "Molecular genetics of esophageal squamous cell carcinoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3660446X.
Повний текст джерелаKnezevich, Stevan Robert. "Molecular characterization of pediatric spindle cell tumors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/NQ48668.pdf.
Повний текст джерелаSun, Li. "Molecular cytogenetics of oral squamous cell carcinoma." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/HKUTO/record/B38627887.
Повний текст джерелаRytkönen, Anne. "Molecular studies of Neisseria - host cell interactions /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-018-4/.
Повний текст джерелаJames, John Robert. "Molecular organisation of the T cell surface." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437053.
Повний текст джерелаBrodie, Douglas William. "Molecular analysis of T cell costimulatory pathways." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249517.
Повний текст джерелаSims, Stuart. "Molecular profiling CD8+ T-cell memory inflation." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598035.
Повний текст джерелаHu, Yingchuan, and 胡穎川. "Molecular pathogenesis of oesophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241797.
Повний текст джерелаSun, Li, and 孫莉. "Molecular cytogenetics of oral squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B36544267.
Повний текст джерелаLaw, Bic-fai Fian, and 羅璧輝. "Molecular genetics of esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3660446X.
Повний текст джерелаMorrissey, Catherine. "The molecular pathology of renal cell carcinoma." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420407.
Повний текст джерелаYap, Lee Fah. "Molecular characterization of oral squamous cell carcinoma." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435716.
Повний текст джерелаLambert, Sally Ruth. "Molecular profiling of cutaneous squamous cell carcinoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/564.
Повний текст джерелаMathur, Divya Ph D. Massachusetts Institute of Technology. "Molecular control of embryonic stem cell identity." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46786.
Повний текст джерелаThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references.
Embryonic Stem (ES) cells are the in vitro derivatives of the inner cell mass of a developing embryo, and exhibit the property of pluripotency, which is the ability of a cell to give rise to all cell lineages of an organism. Therefore, these cells hold great promise in the treatment of several degenerative diseases through patientspecific cell-based therapy. Consequently, a detailed knowledge of the factors regulating ES cell identity is required in order to exploit this therapeutic potential. In order to address this subject, genome-wide location analysis (or ChIP-chip) has been used to identify downstream genes that are bound, and potentially regulated by the key pluripotency transcription factors, Oct4 and Nanog. The data from this study have also been compared and integrated with Oct4 and Nanog DNA binding data obtained in a different study using the ChIP-PET technology. In order to gain further insight into the mechanisms by which the transcription factor Nanog regulates its downstream targets, an attempt at identifying proteins interacting with Nanog has also been described. Research on ES cells has been plagued with ethical controversies since the creation of these cells requires the destruction of embryos. Recent studies have reported the reprogramming of somatic fibroblasts into an ES cell-like induced pluripotent state (iPS) by virus-mediated transduction of four transcription factors-- Oct4, Sox2, c-Myc and Klf4, thereby circumventing the use of embryos in producing pluripotent cells.In these studies, selection for the activation of the markers Oct4 or Nanog led to completely reprogrammed cells, but selection for fbx15, a downstream target of Oct4, resulted in partially reprogrammed intermediates. An unresolved issue in the field was whether these intermediates were obtained due to early drug selection in the case of fbx15 selection, or because Fbx15 expression is not relevant to pluripotency. Drug selection for fbx15 activation at later time-points, and an examination of the methylation status of the Oct4 locus of Fbx15-iPS cells suggests that the intermediates were obtained due to early drug selection and not due to selection for fbx15. Therefore, these studies have begun to elucidate a framework that governs ES cell identity, and the mechanism by which a differentiated cell can be reprogrammed into a pluripotent state.
by Divya Mathur.
Ph.D.
Noordin, Liza. "Molecular mechanisms of cell proliferation in endometriosis." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16808.
Повний текст джерелаGriffiths, Dean Stuart. "Molecular characterisation of embryonic stem cell neurogenesis." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/13958.
Повний текст джерелаLaird, Alexander. "Molecular prognostic markers in renal cell carcinoma." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17873.
Повний текст джерелаShannon, Matthew Frederick. "The molecular biology of sickle cell anaemia." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/the-molecular-biology-of-sickle-cell-anaemia(d4d29fde-2799-4f3f-b499-b5ae0f5b6782).html.
Повний текст джерелаOliveira, Marta Isabel Abreu. "Molecular interactions at the T cell surface." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7220.
Повний текст джерелаSzymanska, Katarzyna. "Molecular genetics and cell biology of ciliopathies." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/8891/.
Повний текст джерелаGodec, Jernej. "Molecular Mechanisms of CD8+ T Cell Differentiation." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493424.
Повний текст джерелаMedical Sciences
Rai, Varun. "Molecular modeling of PEM fuel cell electrochemistry /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Повний текст джерелаOliveira, Marta Isabel Abreu. "Molecular interactions at the T cell surface." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7220.
Повний текст джерелаLantela, Daniel. "CUX1 and the Cell Cycle." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119509.
Повний текст джерелаCUX1 est un facteur de transcription impliqué dans la régulation de la prolifération cellulaire. La surexpression de CUX1 est observée dans de nombreuses tumeurs humaines et lignées de cellules cancéreuses. Les cellules qui surexpriment constitutivement l'isoforme p110 de CUX1 prolifèrent plus rapidement et passent moins de temps en G1 après quiescence. Nous avons étudié trois aspects de la régulation de CUX1 au cours du cycle cellulaire. Dans la première partie de cette étude, nous avons analysé le mécanisme par lequel la surexpression de p110 CUX1 conduit à une réduction dans la durée de la phase G1. En utilisant la méthode de PCR quantitative, nous avons montré que la surexpression de p110 CUX1 a augmenté la transcription de gènes DDK (Cdc7 et Dbf4) à la sortie de quiescence. L'analyse par immuno-buvardagea révélé que les cellules p110 CUX1 montrent une phosphorylation élevée de pS5-MCM2 pendant la quiescence, ce qui indique une augmentation de l'activité de DDK. Cette phosphorylation élevée est associée à un chargement plus rapide de MCM2 sur la chromatine après entrée dans le cycle cellulaire et un raccourcissement de la phase G1 tel que mesuré par FACS. Dans un deuxième projet, nous avons étudié l'effet de la phosphorylation de CUX1 par le complexe cyclin D1/CDK4 sur la régulation du cycle cellulaire. Des test de liaison à l'AND ont révélé que la phosphorylation d'une protéine recombinante CUX1 (1125-1505) par cyclinD1-CDK4 inhibeé sa liaison à l'ADN tandis que la PKA l'active. À l'inverse, une autre protéine recombinante CUX1 (1125-1308), qui ne contient pas les domaines répression en C-terminaux, est activée par cyclinD1-CDK4 et inhibée par la PKA. L'autoradiographie et l'analyse par immuno-buvardage ont révélé que cyclinD1-CDK4 phosphoryle la sérine 1216, alors que PKA phosphoryle sur les sérines 1215 et 1216. Les analyses par FACS ont montré que les cellules exprimant un mutant p110 CUX1S1215/1216A passent moins de temps en G1, deviennent progressivement plus petites et finissent par mourir par apoptose. Ces résultats suggèrent que la phosphorylation de CUX1 par le complexe cyclinD1-CDK4 sert à contrôler la taille des cellules. Finalement, au cours de la mitose, CUX1 semble ~ 15 kDa plus grands quand on l'observe par SDS-PAGE. Nous avons vérifié si cette différence de poids moléculaire résultait de modifications post-traductionnelles telles que l'ajout d'un peptide de la famille des ubiquitines. Aucune de ces modifications n'a été identifiée, mais en utilisant la spectrométrie de masse, nous avons démontré que, durant la mitose, CUX1 est phosphorylé sur au moins douze résidus par rapport à six au cours de G2.
Banerjee, Sangeeta. "Host cell response to coronavirus infection." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts Internataional, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3025137.
Повний текст джерелаMinhas, Raman. "Cytokine-dependent hemopoietic cell linker : role in immune-cell receptor signaling." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79052.
Повний текст джерелаDelorme, Marilyne. "Downregulation of ATRX disrupts cell proliferation and cell cycle progression." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27627.
Повний текст джерела凌明達 and Ming-tat Patrick Ling. "A study of molecular and cell biology of prostate tumorigenesis in cell culture." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31223102.
Повний текст джерелаAnnunen-Rasila, J. (Johanna). "Molecular and cell phenotype changes in mitochondrial diseases." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514284427.
Повний текст джерелаSong, Yu. "On the molecular bases of dictyostelium cell death." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4052/document.
Повний текст джерелаThe protist Dictyostelium discoideum undergoes development cell death when under starvation. To investigate the molecular mechanism of Dictyostelium cell death, an in vitro system has been used. Dictyostelium cells were starved and then cell death was induced by DIF-1 or c-di-GMP. About 40h after induction, cells underwent vacuolar cell death. DIF-1 is a polyketide, produced by Dictyostelium prespore cells, which induces prestalk cell differentiation. c-di-GMP was well known not only as a second messenger produced and sensed by bacteria but also as a trigger of innate immunity in mammalian cells. Dictyostelium was recently found by another laboratory to produce and sense c-di-GMP. To analyze c-di-GMP signaling in Dictyostelium cell death, we used random mutagenesis and targeted mutagenesis. By using the knockout mutants stlB- and dmtA-, we demonstrated that endogenous or exogenous DIF-1 is required for c-di-GMP signaling in Dictyostelium. In contrast, endogenous c-di-GMP is not necessary for exogenous DIF-1 signaling. As a consequence, we improved the selection step in random mutagenesis by using c-di-GMP and a little DIF-1 as inducers, which produced several mutants. Another part of my project was to test by targeted mutagenesis some hypotheses, based on known information in Dictyostelium or other similar cell death types. Three molecules have been tested, the c-di-GMP putative receptor DDX41, the mitochondrial Ca2+ uniporter (MCU) and the Na+/K+-ATPase (IonA).In summary, during my thesis, we have demonstrated a relation between c-di-GMP signaling and DIF-1 signaling in Dictyostelium and identified several new cell death molecules by random mutagenesis
Child, Fiona Jane. "Molecular studies in primary cutaneous B-cell lymphoma." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408514.
Повний текст джерелаHobman, Tom Cunningham. "Molecular cell biology of Rubella virus structural proteins." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/30614.
Повний текст джерелаMedicine, Faculty of
Medical Genetics, Department of
Graduate