Дисертації з теми "CD155"
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Martel, André Bernard. "Targeting CD155 on Myeloid Derived Suppressor Cells to Prevent Postoperative Immunosuppression in Cancer Patients." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41151.
Повний текст джерелаMaier, Michael Klaus. "Studien zur Funktion von murinem CD155 bei der Migration von Leukozyten und der Entstehung einer humoralen Immunantwort." kostenfrei, 2007. http://d-nb.info/988269511/34.
Повний текст джерелаBaury, Béatrice. "CD155, un membre de la superfamille des immunoglobulines : homologies avec le gène Tage4 du rat, expression des formes membranaires et solubles." Nantes, 2002. http://www.theses.fr/2002NANT21VS.
Повний текст джерелаOur project focused on two members of the immunoglobulin superfamily, the rat Tage4 gene, which is overexpressed in rat and mice colon tumors, and the human CD155 gene coding for the poliovirus (PV) receptor. We have determined the structural organisation of the Tage4 gene by designing a DNA walking method to isolate the promoter region. Our results have underlined the existence of numerous homologies between Tage4 and CD155. Moreover, the product of the Tage4 gene can mediate entry into cells of the viruses, except PV, that use CD155 as a receptor. These structural and functional homologies suggest that the Tage4 gene is probably orthologous to the gene for CD155. Besides, we have shown by RT-PCR and immunohistochemistry that CD155 is overexpressed in colorectal carcinoma. As the carcinoembryonic antigen (CEA), the CD155 overexpression is an early event in colon carcinogenesis. However, unlike the CEA, the CD155 expression is not regulated by the interferon gamma nor by the nuclear receptor PPAR gamma (Peroxisome Proliferator-Activated Receptor). We have demonstrated the existence of CD155 secreted isoforms by immunoprecipitation in serum, in cerebrospinal fluid and in culture medium of polarised epithelial cell. .
Jassam, Samah Ali. "Role of CD15 and CD15s in the cellular mechanisms of cancer cell metastasis from lung to the brain." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/role-of-cd15-and-cd15s-in-the-cellular-mechanisms-of-cancer-cell-metastasis-from-lung-to-the-brain(de581581-027d-4106-9c23-9daa534d684f).html.
Повний текст джерелаZevian, Shannin Christine. "Structure-function analysis of Tetraspanin CD151." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/3022.
Повний текст джерелаRomanets, Olga. "Study of the role of measles virus receptor CD150 in viral immunopathogenesis and characterization of novel CD150 isoform." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00923189.
Повний текст джерелаMoyano, Rodríguez Yolanda 1992. "Mitosis exit regulation by Cdc5 and PP2A-Cdc55." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668051.
Повний текст джерелаEn esta tesis hemos investigado el papel de la fosfatasa PP2ACdc55 en la regulación de la citocinesis y la contribución de la quinasa Cdc5 en la salida de mitosis en la levadura de gemación. Previamente, se había sugerido un posible papel de la PP2ACdc55 en citocinesis basándose en el fenotipo elongado en ausencia de Cdc55. Sin embargo, la función de la PP2ACdc55 durante la citocinesis y sus sustratos no han sido estudiados. En esta tesis, hemos demostrado que la PP2ACdc55 regula la desfosforilación de las proteínas de IPC que regulan la citocinesis; así como, su tiempo de localización en el cuello. Además, hemos observado como la PP2ACdc55 realiza un papel en la coordinación de la contracción del anillo de actomiosina y la formación del septo. En cuanto a Cdc5, analizamos los posibles residuos de Net1 fosforilados por Cdc5 que contribuyen a la liberación de Cdc14 en la salida de mitosis.
Maurik, Andre van. "The role of CD40-CD154 interactions in allograft transplantation." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249302.
Повний текст джерелаDewitte, Antoine. "Plaquettes sanguines et insuffisance rénale aiguë : rôle du couple CD154/CD40 dans la constitution des lésions tubulaires." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0906.
Повний текст джерелаAcute kidney injury (AKI) is a common complication in critically ill patients and is associated with increased morbidity and mortality. Sepsis is the most common cause of AKI. The understanding of sepsis pathophysiology and its complications has progressed significantly in recent years but has not yet been translated into significant therapeutic advances in clinical practice. The traditional paradigm that sepsis-induced AKI is linked to renal hypoperfusion has been challenged by recent evidences showing that renal blood flow is not universally impaired during sepsis,and that AKI can develop in the presence of normal or even increased renal bloodflow. Sepsis is characterized by profound alterations of the immune response and adisproportionate inflammatory response. Inflammation and microcirculatorydysfunction are now considered as fundamental pathophysiological mechanisms atthe origin of renal injuries. Beyond haemostasis, the contribution of platelets ininflammation, tissue integrity and defence against infections has considerablywidened the spectrum of their role and made them potential physiopathologicalactors in sepsis. Platelets fulfil most of these functions through the expression ofmembrane-bound or soluble mediators. Among them, CD154 holds a peculiarposition, as platelets represent a major source of CD154 and as CD154 is a centralregulator of inflammation. Here, we provide an overview of these recentpathophysiological advances and discuss the platelets and CD154 contribution tomicrocirculatory alterations in multi-organ dysfunction in sepsis. We investigated thepro-inflammatory role of CD154 under hypoxic conditions in the renal tubularepithelium as recent data highlight the importance of hypoxia in the inflammatoryreaction. We studied the control of interleukin (IL)-6 production, a key cytokineinvolved in inflammation, by CD154 in oxygen deprivation conditions using a kidneytubular epithelial (TEC) cell line model. We also studied a murine model of kidneyinjury after ischemia/reperfusion, a model that was applied in CD154 and CD40deficient mice. We found that CD154 is a potent inducer of IL-6 secretion by TEC inhypoxia and that CD154-deficient mice regenerate earlier the tubular epithelium afterischemia/reperfusion injury. These findings may provide potential avenues for septicAKI management and therapy
Higa, Ryoko. "CD105 maintains the thermogenic program of beige adipocytes by regulating Smad2 signaling." Kyoto University, 2018. http://hdl.handle.net/2433/235056.
Повний текст джерелаAbbott, Rachel J. M. "Structural studies on CD55 and its human ligands." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491284.
Повний текст джерелаMorgan, Joanne. "The role of CD55 in the tumour environment." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275151.
Повний текст джерелаTregaskes, Clive. "Characterization of the chicken orthologues of mammalian CD154 and CD40." Thesis, University of Reading, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493816.
Повний текст джерелаBradley, Richard Grayson. "Development of cancer immunotherapeutics targeting complement regulatory protein CD55." Thesis, University of Nottingham, 2007. http://eprints.nottingham.ac.uk/10258/.
Повний текст джерелаFitzGibbon, Hannah. "CD55 as a modulator of the adaptive immune response." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438276.
Повний текст джерелаGriffiths, Meryn Ruth. "Investigation of the α3β1/CD151 complex association and function." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397105.
Повний текст джерелаBaldwin, Gouri Seetharaman. "The CD151-α3β1 axis and its role in breast cancer progression". Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3372/.
Повний текст джерелаRushworth, Stuart Anthony. "Analysis of CD40 mediated porcine endothelial cell activation by human CD154." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620387.
Повний текст джерелаO’Meara, Kellie Marcella. "Evaluation of Recombinant Salmonella Expressing CD154 for Enhanced Immune Responses in Commercial Turkeys." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1246567532.
Повний текст джерелаKölbel, Beatrice [Verfasser]. "CD15-Fokus-Score: Ein immunhistochemisch basierter Score sowie die Mitentwicklung einer morphometrischen Software („CD15-Quantifier“) zur Infektionsdiagnostik in der periprothetischen Membran / Beatrice Kölbel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1079840869/34.
Повний текст джерелаAlegretti, Ana Paula. "Expressão de proteínas reguladoras do complemento CD55/CD59 em células de sangue periférico de pacientes com lúpus eritematoso sistêmico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13674.
Повний текст джерелаCD55 and CD59 are glycosylphosphatidylinositos-anchored proteins with complement inhibitory properties, which inhibit formation of the C3 convertases and prevent the terminal polymerization of the membrane attack complex, respectively. Systemic Lupus erythematosus patients seem to have an acquired deficiency of CD55 and CD59 proteins associated with secondary autoimmune hemolytic anemia and lymphopenia. But the mechanisms remain unknown and its impact on the clinical manifestation of Systemic Lupus erythematosus needs to be more explored.
Tosello, Annie-Carole. "Implication de la molécule CD55 dans l'activation du lymphocyte T." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX22086.
Повний текст джерелаBaró, Sastre Bàrbara. "New substrates and functions of PP2A-Cdc55 phospatase in the mitotic exit." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/283260.
Повний текст джерелаBrunner-Weinzierl, Monika. "Die Rolle von CD152 (CTLA-4) bei der Begrenzung von T-Zellantworten." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=972713417.
Повний текст джерелаGao, Dingcheng. "On the pathophysiological significance of CD154-CD40 mediated leukocyte endothelial cell interaction." Doctoral thesis, [S.l.] : [s.n.], 2003. http://webdoc.sub.gwdg.de/diss/2003/gao/gao.pdf.
Повний текст джерелаSpeck, Uwe. "Beeinflussung antigenspezifischer humaner T-Zellen durch die Blockade von CD152 (CTLA-4)." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96633809X.
Повний текст джерелаMars, Leonardus Theodorus. "Role of the CD154-CD40 axis in the modulation of autoimmune reactions." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326217.
Повний текст джерелаCuss, Steven Martin. "The CD40-CD154 pathway in the development of Foxp3⁺ regulatory T cells." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610532.
Повний текст джерелаBrunner-Weinzierl, Monika. "Die Rolle von CD152 (CTLA-4) bei der Begrenzung von T-Zellantworten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13941.
Повний текст джерелаDuring adaptive immune responses a broad repertoire of effector T-cells is generated, characterized by diverse functional capabilities. Besides activation of the immune response other mechanisms are needed in order to regulate and terminate responses, thus preventing unwanted immune reactions. Here I focus on the role of CD152 (CTLA-4), a homologue of CD28, in the limitation of T-cell responses. Inhibition of T-cell-proliferation by CD152 was originally attributed to a late regulation of the T-cell proliferation. We now show that CD152 is already able to prevent the activation of T-cells and to set the threshold for their activation. We also show that CD152 inhibits T-cell activation in two ways: It inhibits the induction of the growth-factor IL-2 and it inhibits the expression of G1-kinases mandatory for the progression of the cell cycle. Until now, it has not been possible to detect individual T-cells expressing CD152 at their surface. To analyze the expression of CD152 at the surface of individual cells, we developed a sensitive staining method. Using this technique we could show that antigen-specific stimulation of T-cells leads to the expression of surface-bound CD152 only on a fraction of the activated T-cells. Isolated, activated CD152+ T-cells were inhibited in their proliferation whereas CD152- T cells were not. This also shows that CD152 is indeed able to inhibit already activated T-cells. The heterogenous expression of CD152 at the cell surface of already activated T-cells also suggests that CD152+ T-cells will differentiate differently compared to CD152-T-cells. Repeated or chronic activation of Th-cells leads to one form of apoptosis, activation-induced cell death (AICD), against which Th2-cells are resistant. Activated Th2-cells express surface CD152 at higher frequencies than Th1-cells. We show here, that CD152-crosslinking of activated T-cells directly induces resistance against AICD by a mechanism requiring PI3´kinase. This leads to the inactivation of pro-apoptotic molecules (phosphorylation of FKHRL1 and downregulation of FasL). It also leads to the induction of the survival molecule Bcl-2. Prevention of apoptosis is a central prerequisite for the generation of memory cells. Therefore, surface CD152+ T-cells might be good candidates to differentiate into memory cells. To investigate the role of CD152 during the differentiation of T-cells in vivo, the CD152 gene was conditional mutagenese of the CD152 gene was generated.
Dourado, Keina Maciiele Campos. "Papel da Endoglina/CD105 em leucemias agudas: um potencial alvo para intervenção terapêutica." Universidade Federal da Bahia, 2016. http://repositorio.ufba.br/ri/handle/ri/21386.
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CAPES
O tratamento das leucemias agudas continua sendo um grande desafio clínico devido, principalmente à heterogeneidade e alta toxicidade da terapia padrão utilizada. Dessa forma, novos alvos terapêuticos são urgentemente necessários e os anticorpos monoclonais tem surgido como uma das opções terapêuticas mais promissoras. A endoglina, também conhecida como CD105, é um receptor da superfamília do TGF-β, expresso nas células-tronco hematopoiéticas (HSC) de todos os sítios hematopoiéticos, incluindo a medula óssea, onde é descrita como um marcador para HSC de longo prazo. Apesar da expressão de CD105 ter sido relacionada a diversos tipos de tumores sólidos, principalmente devido ao papel desse receptor na angiogênese, relativamente pouco é conhecido em relação a expressão de CD105 e a sua função em neoplasias hematopoiéticas. Este estudo revelou alta expressão de endoglin na maioria dos blastos de pacientes com leucemia mieloide aguda (LMA) e leucemia linfoblástica aguda (LLA). Utilizando um modelo de xenotransplante, verificamos que as blastos CD105+ possuem uma actividade leucemogênica superior em comparação com a população de CD105-. Adicionalmente, investigamos se o bloqueio da endoglina, usando TRC105, poderia resultar em uma opção terapêutica para tratamento das leucemias agudas e descobrimos que na LMA, o TRC105 impediu o engraftment de blastos primários e inibiu a progressão da leucemia após o estabelecimento da doença, mas na LLA, o TRC105 sozinho foi ineficaz devido à uma maior secreção da forma soluvél da endoglina (sENG). No entanto, tanto na LLA quanto na LMA, TRC105 potencializou o efeito terapeutico da quimioterapia padrão e inibiu a progressão da doença, indicando que TRC105 pode representar uma nova opção terapêutica para LLA e LMA.
Successful treatment of acute leukemia remains a clinical challenge due to the toxicity and the relatively poor responses to the current standard therapy. Thus, treatments that address novel therapeutic targets are urgently needed and, for this purpose, monoclonal antibodies have been one of the most promising strategy once they are able to deliver their therapeutic effects with minimal toxicity. Endoglin, also known as CD105, is a receptor of the transforming growth factor-beta (TGF-β) superfamily that has been found expressed in hematopoietic stem cells (HSCs) from all hematopoietic sites, including the bone marrow, in which it is described as a marker for long-term HSC. CD105 is also found to be expressed in several cancers. However, because CD105 expression has been studied mostly in the context of solid tumors and angiogenesis, relatively little is known about CD105 expression and role in hematopoietic malignancies. We identified endoglin expression on the majority of blasts from patients with acute myeloid leukemia (AML) and acute B-lymphoblastic leukemia (B-ALL). Using a xenograft model, we find that CD105+ blasts are endowed with superior leukemogenic activity compared to the CD105- population. We test the effect of targeting this receptor using the monoclonal antibody TRC105, and find that in AML, TRC105 prevented the engraftment of primary AML blasts and inhibited leukemia progression following disease establishment, but in B-ALL, TRC105 alone was ineffective due to the shedding of soluble CD105. However, in both B-ALL and AML, TRC105 synergized with reduced intensity myeloablation to inhibit leukemogenesis, indicating that TRC105 may represent a novel therapeutic option for B-ALL and AML.
Degos, Clara. "Contrôle et modulation de la réponse immunitaire par Brucella abortus." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4069/document.
Повний текст джерелаBrucella is a pathogenic intracellular bacterium responsible for a disease, brucellosis. The ability of Brucella to establish a chronic infection is linked to the mechanism it uses to inhibit immune response. Among Brucella infected cells, dendritic cells (DC) and macrophages play a crucial role in the induction of an immune response. We studied the role of one receptor present at the DC, T cells, macrophages surface: CD150. This molecule participates at the T cell activation and it was shown recently that CD150 can recognize bacterial membrane proteins which lead to its own upregulation. We discovered that CD150 expression onto bone-marrow derived DC (BMDC) is increased when these cells are treated with Brucella membrane extracts, except when those extracts are coming from a mutant for Omp25(∆omp25), a Brucella membrane protein. BMDC infection with ∆omp25 leads to BMDC activation regarding co-stimulatory molecule expression, cytokines and chemokines secretion, pro-inflammatory mRNA expression and NF-κB translocation within the nucleus. In comparison with infection with the wild type strain, ∆omp25 induces a higher activation of BMDC. In absence of CD150, NF-κB translocation within the nucleus of infected-BMDC is the same between the wild type strain and ∆omp25. In vivo, CD150 controls Brucella replication in the spleen of infected mice, and Omp25 infection seems to trigger a higher inflammation in control mice. We finally demonstrate that CD150 binds Omp25. Here, we identified a new mechanism by which Brucella is able to inhibit DC activation: binding of Omp25 to CD150. This receptor plays a dual role since it is also required for controlling Brucella growth in mice
Spence, Philip James. "The role of CD154 in the life of a Foxp3⁺ regulatory T cell." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611299.
Повний текст джерелаElzatma, Essameddin. "Study of the regulatory receptor CTLA-4 (CD152) in human myeloid derived cells." Thesis, University of Essex, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548590.
Повний текст джерелаKim, Ji Hye. "microRNA regulation of CD44 and CD151 in hepatocellular carcinoma: Implications for novel therapies." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1436954441.
Повний текст джерелаVilleneuve, Julien. "CD154 et adaptation cellulaire au stress métabolique : exemple de la stéatose hépatique expérimentale." Bordeaux 2, 2008. http://www.theses.fr/2008BOR21591.
Повний текст джерелаNon Alcoholic Fatty Liver Disease (NAFLD) is a major public health concern. Its prevalence is high and its severity is related to the risk of transition towards cirrhosis and hepatocellular carcinoma. A distinctive histological feature of NAFLD is liver steatosis, resulting from the triglyceride accumulation in hepatocytes. The mechanisms underlying liver steatosis are not yet understood, however, the involvement of the endoplasmic reticulum (ER) stress is being increasingly emphasized. Excess lipid input to the hepatocyte disrupts the ER homeostasis, its loading overwhelming its processing abilities, leading to what is termed the ER stress. ER stress activates the unfolded protein response (UPR) that corresponds to the activation of specific signalization pathways, whose effectors aim at adjusting the functional capacities of the ER. ER stress and the inflammatory reaction are linked, but the underlying mechanisms remain obscure. CD154 is a key mediator of inflammation and, therefore, we studied its involvement in the mechanisms leading to liver steatosis. CD154 knock-out mice developed a steatosis when fed with an olive oil-rich diet. When studying the corresponding mechanisms, we found that CD154 amplified the UPR and, more specifically, increased the unconventional splicing of an effector of the UPR, the X-box binding protein 1. Hence, CD154 increases cell adaptation by controlling the ER homeostasis. Our work highlights a new biological function for CD154, which appears to be an important mediator in the natural history of NAFLD
Guo, Baoqiang. "CD105 expression and its effects on TGF-beta signalling, angiogenesis and cell behaviour." Thesis, University of Manchester, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502933.
Повний текст джерелаLukacik, Petra. "Complement regulation at the molecular level : crystallographic structure determination of CD55." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404175.
Повний текст джерелаRichards, Elliott Grant. "The Role of Decay Accelerating Factor in the Pathogenesis of Endometriosis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619689609524397.
Повний текст джерелаSu, Ting-Cheng. "Regulation of pheromone response in saccharomyces by Ste12-PRE interaction and TOR-Cdc55 signaling." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43645.
Повний текст джерелаBlumenthal, Antje [Verfasser]. "Charakterisierung der Tetraspanine CD9, CD81 und CD151 in einer permanenten murinen Podozytenzelllinie / Antje Blumenthal." Greifswald : Universitätsbibliothek Greifswald, 2012. http://d-nb.info/1024147320/34.
Повний текст джерелаHewitson, James Philip. "The role of the CD40/CD154 pathway in protective immune responses against Schistosoma mansoni." Thesis, University of York, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424528.
Повний текст джерелаVoss, Martin August. "An investigation into tetraspanin CD151 as novel prognostic markers in poor outcome endometrial cancer." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5228/.
Повний текст джерелаSeung, Edward. "CD40-CD154 Blockade Facilitates Induction of Allogeneic Hematopoietic Chimerism and Transplantation Tolerance: A Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/103.
Повний текст джерелаPowell, Robert. "Studies on the interaction of enteroviruses with soluble decay-accelerating factor (CD55)." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286023.
Повний текст джерелаSutavani, Ruhcha V. "CD55 costimulation induces differentiation of human T regulatory type - 1 (Tr1) cells." Thesis, University of Nottingham, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727951.
Повний текст джерелаXavier, Ruth Lopes de Freitas. "Estudo da angiog?nese pelo CD105 e FvW no carcinoma epiderm?ide oral e sua rela??o com o estadiamento cl?nico do tumor." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17100.
Повний текст джерелаCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
The purpose of this study was to assess the immunohistochemical expression of CD105 and FvW antibodies in the angiogenesis of oral epidermoid carcinoma (OEC), correlating it with the TNM clinical staging system, seeking a better understanding of its biological behavior and use as an indicator of prognosis.The sample consisted of 30 epidermoid carcinoma (EC) cases, 10 of the floor of the mouth, 10 of the retromolar region and 10 of the tongue, in addition to 10 cases of pyogenic granuloma, which made up the control group. The results showed that mean microvessel counts (MVC) were correspondingly higher in the pyogenic granuloma group (CD105 = 57.26 vessels and FvW = 39.64) than in the EC group (CD105 = 10.09 and FvW = 12.20) and that the differences were statistically significant between the groups for each of the angiogenic biomarkers (p = 0.002 for CD105 and p< 0.001 for FvW). CD105 had better positivity in the pyogenic granuloma group (mean = 57.26 vessels) and for EC, FvW had the highest expression (mean = 12.20 vessels). With respect to EC, the most affected age group was between 51 and 70 years (n = 14; 46.7%), with a representative MVC for both markers. No statistically significant difference was found between the sexes for any of the markers (p = 0.967 for CD105 and p = 0.744 for FvW). Mean CD105 levels were much higher in patients with stage T3 and T4 (17.13) and lower in those with stage N+ (6.36). Mean FvW levels were higher in the patients with stage T1 and T2 (12.23) and lower in patients with T3 and T4 (12.10), but without a statistically significant difference. In regard to anatomic location, a statistically significant difference was observed between FvW sites, with a statistically significant difference between floor of the mouth cases and those located in the retromolar region (p =0.013). Therefore, this study suggests that CD105 expression in OEC angiogenesis, in contrast to other types of malignant neoplasias, may not be correlated with prognosis and tumor aggressiveness, whereas FvW was a more effective antibody for staining this lesion
Nesta pesquisa buscou-se avaliar a express?o imunoistoqu?mica dos anticorpos CD105 e FvW na angiog?nese do Carcinoma Epiderm?ide Oral (CEO), correlacionando-o com o estadiamento cl?nico pelo sistema TNM, visando uma melhor compreens?o do seu comportamento biol?gico e utiliza??o como indicador de progn?stico. A amostra foi composta por 30 casos de CE, sendo 10 de assoalho bucal, 10 da regi?o retromolar e 10 de l?ngua, al?m de 10 casos de granuloma piog?nico, integrantes do grupo controle. Os resultados desta pesquisa mostraram que as m?dias da MVC foram correspondentemente mais elevadas no grupo do granuloma piog?nico (CD105 = 57,26 vasos e FvW = 39,64) do que no grupo do CE (CD105 = 10,09 e FvW = 12,20) e as diferen?as se revelaram estatisticamente significantes entre os grupos para cada um dos biomarcadores angiog?nicos (p=0,002 para o CD105 e p<0,001 para o FvW ). O CD105 se mostrou com melhor positividade no granuloma piog?nico (m?dia = 57,26 vasos) e, para o CE, o FvW foi o que apresentou maior marca??o (m?dia = 12,20 vasos). Com rela??o ao CE, a faixa et?ria mais acometida foi entre 51 e 70 anos (n=14; 46,7%), apresentando uma MVC representativa para ambos os marcadores. N?o se comprovou diferen?a estatisticamente significante entre os sexos para nenhum dos marcadores (p=0,967 para o CD105 e p=0,744 para o FvW). A m?dia do CD105 foi bem mais elevada entre os pacientes com estadiamento T3 e T4 (17,13) e menos elevada entre os pacientes com estadiamento N+ (6,36). Quando se avaliou o FvW, a m?dia foi mais elevada no grupo dos pacientes com T1 e T2 (12,23), sendo mais baixa nos pacientes com T3 e T4 (12,10), por?m sem diferen?a estatisticamente significante. Em rela??o ? localiza??o anat?mica, comprovou-se diferen?a estatisticamente significante entre as localiza??es assoalho bucal e retromolar (p=0,013) para o marcador FvW. Portanto, este estudo sugere que a marca??o do CD105 na angiog?nese do CEO, ao contr?rio de outros tipos de neoplasias malignas, pode n?o estar correlacionada com o progn?stico e agressividade do tumor, enquanto que o FvW se mostrou um anticorpo mais efetivo na marca??o desta les?o
Hegel, Johannes Kolja Eberhard [Verfasser]. "Untersuchung der CD152 vermittelten Regulation der Effektorfunktionen von CD8 T-Lymphozyten / Johannes Kolja Eberhard Hegel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1023094584/34.
Повний текст джерелаLiu, Donghui. "The role of CD105 in angiogenesis and its effect on cell signalling and gene expression." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493918.
Повний текст джерелаHüttner, Éder Abreu. "Expressão da endoglina (CD105) em carcinomas epidermóide de cavidade oral de pacientes adultos e idosos." Pontifícia Universidade Católica do Rio Grande do Sul, 2006. http://hdl.handle.net/10923/3677.
Повний текст джерелаSquamous cell carcinoma (SCC) is the main malignant neoplasy of the oral cavity. The higher incidence of this tumor occurs between the fourth and seventh decade of life, and it has been found a raise in the number of young adults with this pathology in several regions of the world. The aim of this study was to compare anatomopathological characteristics and endoglin expression in the groups of adults (<60 years) and elderly (>/= 60 years). In this study, 27 samples of oral SCC were analisesd. Of the total, 14 specimens were from adult patients and 13 specimens were from elderly patientsThe results showed that a low grade of malignancy, a low pattern of invasion, The clinical, the anatomopathological aspects and the patterns of neoangiogenesis, through the expression of endoglin glycoprotein (CD105) in the groups of adults and elderly, were compared. a high degree of keratinization and a low number of mitosis in the elderly group were statistically significant at (p<0,03, p<0,04, p<0,04, p<0,04, respectively). Neoangiogenesis evaluated through of endoglin expression did not show statistically significant differences in both studied groups. Based on the presented results, in can be concluded that oral SCC of elderly patients show lower grade of malignancy and some anatomopathological characteristics that suggest lower tumoral aggressiveness when compared. However, quantitative alteration of endoglin expression in the analysed groups was not detected.
O carcinoma epidermóide (CEB) é a principal neoplasia maligna da cavidade bucal. A maior incidência desse tumor ocorre entre a quarta e sétima década de vida, sendo que tem sido constatado um aumento no número de adultos jovens com esta patologia em várias regiões do mundo. O objetivo deste estudo foi comparar as características anátomo-patológicas e a expressão da endoglina (CD105) em CEBS dos grupos etários adultos (< 60 anos) e idosos (>/= 60 anos). Foram utilizadas 27 amostras de CEBs, entre as quais 14 espécimens eram oriundas de pacientes adultos e 13 espécimens de pacientes idosos. Foram comparados os aspectos clínicos, anátomopatológicos e os padrões de neoangiogênese, através da expressão da glicoproteína endoglina (CD 105) entre os grupos de adultos e idosos.Os resultados mostraram que a baixa gradação de malignidade, o baixo padrão de invasão, o alto grau de queratinização e o baixo número de mitoses no grupo de idosos foram estatisticamente significantes para (p<0,03), (p<0,04), (p<0,04), (p<0,04), respectivamente, quando comparado com o grupo de adulto a neo-angiogênese avaliada através da quantificação da expressão da endoglina não apresentou diferenças estatisticamente significante para (p<0,05) em ambos grupos estudados. Considerando os resultados apresentados neste estudo, pode-se concluir que os CEBs de pacientes idosos apresentam menor gradação de malignidade e algumas características anátomo-patológicas que sugerem menor agressividade tumoral em relação aos adultos, entretanto, não houve alteração quantitativa da expressão da endoglina entre os grupos analisados.
Rocha, Andréa Oxley da. "Avaliação imuno-histoquímica da densidade vascular intratumoral com CD105 em espécimes cirúrgicos de vesícula biliar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/12934.
Повний текст джерела