Дисертації з теми "CB7"
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Bayer, Michael J. "Neue Carborane aus CB2-, CB3- und C2B2-Organoboranen." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964277573.
Повний текст джерелаChui, Daniel. "Action of CB1 and CB2 antagonists/inverse agonists on mantle cell lymphoma." Thesis, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12279.
Повний текст джерелаEtayo, Labiano Iñigo Javier. "Heterómeros de receptores CB1, CB2 y GPR55 y su implicación en enfermedades neurodegenerativas y alcoholismo." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586086.
Повний текст джерелаCB1 and CB2 receptors are part of the mammalian endocannabinoid system, which is involved in neurologic alterations involving neuroinflammation. Considering these precedents, in this thesis project the main objectives were to demonstrate the implication of cannabinoid receptor heteromers in the regulation of neuroinflammatory processes in activated microglia, in the context of neurodegenerative diseases such as Parkinson’s or Alzheimer’s diseases. Using N9 cells and animal models of Parkinson’s and Alzheimer’s diseases, along with Bioluminescence resonance energy transfer and microscopy techniques, we could demonstrate that the action of cannabinoids on CB1R/CB2R heteromers are potentiated in activated microglia. Using advanced techniques for the study of cell signaling, we were able to prove relevant changes in the signaling of cannabinoid receptors. Whereas in resting cells we could observe negative cross-talk between CB1 and CB2 receptors, in activated microglia this phenomenon changed to a positive cross-talk. Taking in mind these results, and with further investigation, the endocannabinoid system is a promising therapeutic target in neurodegenerative and neuroinflammatory diseases. The endocannabinoid system is also implicated in some addiction processes such as alcoholism. It’s also important to note that in alcoholism the hippocampus is altered. In the second part of this Thesis, we aimed to study the effect of ethanol in the signaling of CB2R, GPR55 (which is related with the endocannabinoid system) and the heteromer CB2R/GPR55. Using transfected HEK-293T cells and primary cell cultures from rat hippocampus, along with Bioluminescence resonance energy transfer and microscopy techniques, we could determine that ethanol did not affect heteromerization. However, cell signaling analysis determined that ethanol inhibits ERK1/2 phosphorylation induced by CB2R and CB2R/GPR55 activation. Calcium signaling analysis of GPR55 resulted in a potentiation of the signal; presumably because of ethanol. We could also study CB2R and GPR55 heteromerization in prefrontal cortex of human alcoholic patients, using proximity ligation assays. Using this approach, we could determine that, compared with age-matched controls, there is an increase in the expression of heteromers. With these interesting results, it is possible to point cannabinoid receptors as therapeutic targets in alcoholism.
Julien, Boris. "Mise en évidence du rôle des récepteurs des cannabinoides CB1 et CB2 dans la fibrogénèse hépatique." Paris 11, 2005. http://www.theses.fr/2005PA11T062.
Повний текст джерелаDeveaux, Vanessa. "Mise en évidence de deux nouvelles fonctions du système endocannabinoïde dans la physiopathologie de la stéatose hépatique : propriétés stéatogènes du récepteur CB2 et profibrogéniques du récepteur CB1." Phd thesis, Université Paris-Est, 2008. http://tel.archives-ouvertes.fr/tel-00462145.
Повний текст джерелаGaertzen, Oliver. "Asymmetrische Synthese von C1-C9- und C17-C27-Fragmenten der Bryostatine und De-novo-Synthese enantiomerenreiner Glycosidderivate." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=958049645.
Повний текст джерелаGonzález, Dorasco Brenda Montserrat. "Expresión de los receptores de endocanabinoides CB1 y CB2 en leucocitos de ratones suplementados con edulcorantes comerciales." Tesis de maestría, Universidad Autónoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/105342.
Повний текст джерелаEl sobrepeso y la obesidad ocasionados por consumo excesivo de alimentos con alto contenido energético es uno de los principales problemas de salud que afectan a la sociedad actualmente. Estas patologías están ligadas a alteraciones del sistema inmunológico que inducen inflamación crónica de bajo grado, que a su vez promueve alteraciones metabólicas como la resistencia a la insulina y el desarrollo de enfermedades crónicas no transmisibles. Una consecuencia de la inflamación crónica es la liberación de moléculas de señalización que inhiben los efectos negativos de la inflamación y regresan al organismo a la homeostasis. Entre ellas, la señalización dependiente de endocanabinoides es esencial para la regulación del metabolismo energético y el funcionamiento del sistema inmunológico, principalmente por la señalización a través de los receptores específicos para endocanabinoides CB1 y CB2. Los receptores CB se localizan en múltiples tipos de células y tejidos, incluyendo el cerebro y los órganos linfoides primarios y secundarios. En años recientes, ha habido un interés mayor en analizar las consecuencias de las modificaciones dietéticas sobre el sistema inmunológico, debido a su papel como el principal sistema de defensa del organismo. Igualmente, ha habido interés en determinar la utilidad de las modificaciones nutricionales para modular funciones fisiológicas relevantes, incluyendo la producción de endocanabinoides y su señalización en diversos tejidos. El objetivo de este estudio fue analizar las diferencias en la expresión de los receptores CB1 y CB2 en el bazo y timo de ratones adultos BALB/c, machos y hembras, suplementados con edulcorantes nutritivos y no nutritivos durante 6 semanas. Nuestros resultados muestran un incremento en la expresión de receptores CB1 en el bazo de ratones hembras suplementados con sucralosa, mientras que los ratones machos del mismo grupo muestran una disminución en la expresión de este receptor, comparados con controles sin suplementación. En contraste, la expresión de CB2 se incrementó en ratones machos suplementados con sacarosa, pero no en las hembras. La expresión de CB1 en el timo mostró un descenso significativo entre los grupos de sucralosa y glucósidos de esteviol en machos, pero no se observaron diferencias en las hembras. Finalmente, la expresión de CB2 en el timo fue más variable, con la sacarosa y sucralosa causando una disminución en la expresión de CB2 en machos y la sacarosa incrementando su expresión en hembras, comparados con los controles. Nuestros resultados muestran que el consumo frecuente de edulcorantes no nutritivos tiene efectos diferenciales dependientes del sexo sobre la expresión de los receptores CB1 y CB2 en el bazo y timo, lo que puede implicar alteraciones en las funciones del sistema inmunológico.
N/A
Vakalopoulos, Alexandros. "Asymmetrische Fragmentsynthesen des Bryostatins (C1 - C16 und C19 - C27), Pederins (C10 - C17), Leucascandrolids (C1 - C9), Hennoxazols (C2 - C8) und Macrolactins (C11 - C17) neuartige Entschützungsmethoden von SEM-Ethern und Dithianen /." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=959606416.
Повний текст джерелаDos, Santos Gilson Gonçalves 1986. "Involviment of cannabinoids CB1, CB2 recepotrs and KAPT channel in the anti-hiperalgesic effect mediated by dipyrone and its bioactives metabolites = Envolvimento dos receptores canabinóides CB-1 e CB-2 e canais KATP do tecido periférico na analgesia mediada pela dipirona e seus metabólitos bioativos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313994.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: A dipirona (metamizol) é um pró-fármaco analgésico utilizado no controle da dor moderada, sendo metabolizada em dois metabolitos bioativos: 4-metil-aminoantipirina (4-MAA) e 4-aminoantipirina (4-AA). O objetivo deste estudo foi investigar a participação de receptores canabinóides periféricos, CB1, CB2 e canais de KATP sobre o efeito anti-hiperalgésico da dipirona, 4-MAA ou 4- AA. Para indução de hiperalgesia, PGE2 (100 ng/pata ) foi administrada localmente na pata traseira de ratos Wistar machos, e o limiar hiperalgésico mecânico foi quantificado por Von- Frey eletrônico, antes e três horas após a injeção. Dipirona, 4-MAA ou 4-AA foram administrados 30 minutos antes do Von Frey. Os antagonistas seletivos do receptor CB1 (AM251), CB2 (AM630) e glibenclamida, um bloqueador KATP (80 ug) ou ODQ um inibidor de cGMP (32 ?g) foram administrados 30 minutos antes da Dipirona, 4-MAA ou 4 -AA. O ODN-antisense para reduzir a expressão do receptor CB1 (30 ?g) foi administrado por via intratecal, uma vez por dia durante quatro dias consecutivos. A hiperalgesia mecânica induzida pela PGE2 foi reduzida pela dipirona, 4-MAA, e 4-AA de maneira dose-dependente. AM251 ou ODN-antisense contra o receptor neuronal CB1, mas não AM630, reduziu o efeito anti-hiperalgésico mediado por 4-AA, mas não da dipirona ou 4-MAA. Por outro lado, o efeito anti-hiperalgésico da dipirona, ou 4-MAA foi revertido por glibenclamida ou ODQ. Os resultados sugerem que a ativação de receptores neuronal CB1, mas não do receptor CB2, no tecido periférico esteja envolvido no efeito anti-hiperalgésico do metabólito 4-AA. Além disso, a dipirona e 4-MAA possui um efeito anti-hiperalgesico dependente de cGMP e consequente abertura KATP
Abstract: Dipyrone (metamizole) is an analgesic pro-drug used to control moderate pain. It is metabolized in two bioactive metabolites: 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine (4-AA). The aim of this study was to investigate the participation of peripheral CB1 and CB2 cannabinoid receptors activation on the anti-hyperalgesic effect of Dypirone, 4-MAA or 4-AA. For induction of hyperalgesia, PGE2 (100 ng) was locally administrated in hindpaw of male Wistar rats, and the mechanical nociceptive threshold was quantified by electronic von-Frey, before and 3 hours after its injection. Dypirone, 4-MAA or 4-AA was administrated 30 minutes before the von-Frey test. The selective CB1 receptor antagonist AM251, CB2 receptor antagonist AM630, cGMP inhibitor ODQ (32 ?g) or KATP blocker glibenclamide (80 ?g) was administrated 30 minutes before Dypirone, 4-MAA or 4-AA. The antisense-ODN against CB1 receptor expression (30 ?g) was intrathecally administrated once a day during four consecutive days. PGE2-induced mechanical hyperalgesia was inhibited by dypirone, 4-MAA, and 4-AA in a dose-response manner. AM251 or ODN anti-sense against neuronal CB1 receptor, but not AM630, reversed the antihyperalgesic effect mediated by 4-AA, but not by dypirone or 4-MAA. On the other hand, the anti-hyperalgesic effect of dypirone or 4-MAA was reversed by Glibenclamide or ODQ. These results suggest that the activation of neuronal CB1, but not CB2 receptor, in the peripheral tissue is involved in the anti-hyperalgesic effect of 4-aminoantipyrine. In addition, 4- methylaminontipyrine mediates anti-hyperalgesic effect by the cGMP activation and the KATP opening
Mestrado
Fisiologia
Mestre em Biologia Funcional e Molecular
Reyes, Resina Irene. "Heterómeros de receptores CB1, CB2, GPR55 y GPR18: Señalización celular, farmacología y análisis de su potencial como dianas terapéuticas de enfermedades neurodegenerativas." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586258.
Повний текст джерелаCannabinoid CB1 (CB1R) and CB2 (CB2R) receptors are GPCRs of the mammalian endocannabinoid system.Their complex pharmacology is delaying the translational success of medications targeting the endocannabinoid system. To better understand CB2R pharmacology, a novel homogeneous technique was developed to study ligand binding to CB2R in living cells, which disclosed a second affinity state of CB2R and conformational changes when CB2R interacts with another GPCR. To know how cannabinoid signaling is affected by receptor-receptor interactions, we studied whether CB1R and CB2R interact with two orphan GPCRs, namely GPR55 and GPR18. CB1R-GPR55 and CB2R-GPR18 heteromers were detected both in transfected cells and in the central nervous system, and their fingerprint was also revealed. Given the neuroprotective role of CB2R activation to prevent neuroinflammation, the presence of CB1R-CB2R and CB2R-GPR18 heteromers was studied in both resting and activated microglia. The higher number of complexes and the differential signalling found both in activated microglia and in the brain of animal models of neurodegenerative diseases, indicate that CB1R-CB2R and CB2R-GPR18 heteromers have a role in neuroprotection. Other pathologies where cannabinoid receptors have shown an important role are anxiety and depression disorders, which are related to suicide. The presence of the previously described CB2R-GPR55 heteromer was detected in human prefrontal cortex, and a higher amount of heteroreceptor complexes was found in samples from suicide victims, indicating that CB2R-GPR55 heteromers could have a role in depression. To further exploit the therapeutic potential of the cannabinoids, it is also important to understand how phytocannabinoids, such as cannabidiol and cannabigerol, two compounds found in the cannabis plant and which lack psychoactive effects, interact with CB1R and CB2R. Nanomolar concentrations of cannabidiol modulated in a negative way the affinity of the binding of agonists to CB2R as well as the signaling mediated by this receptor. Thus, it is postulated that cannabidiol is an allosteric modulator of CB2R. In contrast, cannabigerol appears to bind to the orthosteric center of CB1R and CB2R, where it acts as an agonist with functional selectivity, and modulates the signaling of the cannabinoids on CB1R-CB2R heteromers.
Mercado, Beltrán Alejandra. "Relación entre el consumo de edulcorantes no nutritivos y la expresión de los receptores CB1 y CB2 en tejido pancreático y hepático de ratones." Tesis de maestría, Universidad Autónoma del Estado de México, 2020. http://hdl.handle.net/20.500.11799/109774.
Повний текст джерелаLos receptores CB1 y CB2 del sistema endocanabinoide tienen funciones importantes en el hígado y el páncreas, ya que participan en funciones esenciales como la regulación del metabolismo celular, la liberación de insulina y la homeostasis de la glucosa. En general, las dietas de alta energía promueven la activación de los receptores CB, que cuando se estimulan crónicamente, se asocian con anomalías metabólicas e inflamación en condiciones como la obesidad y la diabetes. La ingestión de edulcorantes no nutritivos se ha expandido en poblaciones de todo el mundo con el propósito de reducir el contenido energético de la dieta y para el control de enfermedades crónicas asociadas con alteraciones del metabolismo energético; sin embargo, se desconocen los posibles efectos de estos compuestos sobre la regulación del sistema endocanabinoide a nivel hepático y pancreático. El objeto de estudio fue evaluar la presencia de cambios en la expresión de los receptores CB1 y CB2 en páncreas e hígado de animales experimentales a quienes se les suministraron edulcorantes no nutritivos comerciales (glucósidos de esteviol o sucralosa) en un período de 6 semanas. Después de la suplementación, se analizó la expresión de los receptores CB1 y CB2 de ambos tejidos mediante la técnica de western blot e inmunofluorescencia. Los resultados muestran reducciones significativas en la expresión de CB1 y CB2 en hígado, particularmente en animales machos suplementados con glucósidos de esteviol, con tendencias hacia una expresión reducida de CB1 en páncreas en el mismo grupo. Por el contrario, hubo una tendencia hacia una mayor expresión de CB1 hepático en animales hembra suplementados con sacarosa, sucralosa o glucósidos de esteviol. Estos datos apuntan a que la ingestión frecuente de edulcorantes no nutritivos específicos promueve alteraciones dependientes del sexo en la expresión de los receptores CB en el páncreas y el hígado in vivo.
Telles, Edilia Salvatierra. "Aspectos imunologicos e parasitologicos na infecção multipla por Trypanosoma cruzi (CEPA Y) e Schistosoma mansoni (CEPA BH) em camundongos (CBA X C57 B1/10) F1." [s.n.], 1990. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317081.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Mestrado
Imunologia
Mestre em Ciências Biológicas
Dunkel, Ralf. "Asymmetrische Synthese der C17-C23 und C31-C37 Segmente von Spongistatin 1, de novo Synthese von C-Glycosid-Vorläufern und [beta]-C-Glycosiden [Beta-C-Glycosiden]." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=957653050.
Повний текст джерелаDeveaux, Vanessa Lotersztajn Sophie. "Mise en évidence de deux nouvelles fonctions du système endocannabinoïde dans la physiopathologie de la stéatose hépatique propriétés stéatogènes du récepteur CB2 et profibrogéniques du récepteur CB1 /." S. l. : S. n, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0494586.pdf.
Повний текст джерелаVan, Bui Emily, and Maria Lindqvist. "Processkartläggning CBI Betonginstitutets ledningssystem." Thesis, Högskolan i Borås, Institutionen Ingenjörshögskolan, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-16590.
Повний текст джерелаProgram: Industriell ekonomi - arbetsorganisation och ledarskap
Program: Industriell ekonomi - affärsingenjör
Hill, Lesley Ann. "Corticosteroid-Binding Globulin (CBG) : deficiencies and the role of CBG in disease processes." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62186.
Повний текст джерелаMedicine, Faculty of
Obstetrics and Gynaecology, Department of
Graduate
Barros, Cristiane Oliveira de Alencar. "Revisão da correlação mini-CBR/CBR para solos do município de São Carlos - SP." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18137/tde-10072017-155009/.
Повний текст джерелаThe objective of this work is to review the relation among the results of mini-CBR and CBR tests. This will make possible the use of mini-CBR tests results in flexible pavements design, once this test is more practical, it demands smaller amount of samples, it execution is faster and it demands less physical effort, being, therefore, less expensive than CBR tests. In the development this tests, the results indicated that those relations not shown appropriate for the universe in study, therefore when it tried to relation, graphically, the results of the traditional CBR test with the one of the mini-CBR, not obtained straight line as it was of waiting and yes a cloud of points, indicating not to be correlation among the two indexes. This form, tried to develop new relations, in the molds of what had been done originally by Nogami (1972), and to correlate the values of load CBR test, for the penetrations of 2,5 and 5,0 mm, with the load values developed in the standardized mini-CBR test, for the penetrations of 2,0 and 2,5 mm, respectively, in normal and intermediate compactation energies. In this tests are foundations, the description and some researches realized are approached with the CBR and mini-CBR tests. In this tests will used, 62 soils samples from São Carlos - SP, will be submitted to CBR test, in normal and intermediate compactation energies, and the results will be compared with those ones from mini-CBR test. The samples were chosen considering theproportionality among pedologic class occurrence areas in São Carlos. Finally, to show up the attempts done to utilize of to the maximum the results obtained in the CBR and mini-CBR tests.
Jusufbegovic, Jasmin, and Johan Ottoson. "Tillämpning av CBA inom sjöfartsnäringen." Thesis, Linköping University, Department of Management and Engineering, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57966.
Повний текст джерелаKirkpatrick, David J. A. "Therapists' self-practice of CBT." Thesis, Canterbury Christ Church University, 2015. http://create.canterbury.ac.uk/13921/.
Повний текст джерелаPerez, Córdova Gynna, Saldivar Claudia Ponce, and Marin Alberto Vaivads. "Valorización de CBC Peruana S.A.C." Master's thesis, Universidad del Pacífico, 2019. http://hdl.handle.net/11354/2342.
Повний текст джерелаCalhoun, McKenzie L. "Medical Marijuana, CBD and THC." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6880.
Повний текст джерелаAshley, Diane. "CBL aids in maths/OR /." Leeds : University of Leeds, School of Computer Studies, 2003. http://www.leeds.ac.uk/cgi-bin/library/compst.pl?CAT=BSC&FILE=200304/ashley.pdf.
Повний текст джерелаBoz, Francesco. "Validazione del CBA Young form." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423391.
Повний текст джерелаProgetto di ricerca “CBA forma Giovanile: validazione di una questionario ad ampio spettro per lo screening dei fattori protettivi e predisponenti al disagio psicologico nella popolazione giovanile”. Quadro di riferimento Nello sviluppo delle ricerche del gruppo CBA è stato ideato uno strumento di indagine clinica per la popolazione giovanile: il CBA forma giovani. Il questionario nasce per colmare una lacuna che esiste in Italia per quanto riguarda gli strumenti di assessment e ricerca che siano adatti per persone tra i 14 e 25 anni (Sanavio, et al., 1992; Michelin & Sica, 1996). Il CBA forma Giovani ha lo scopo di valutare le problematiche proprie della tarda adolescenza e della giovinezza nel contesto italiano. Nella costruzione del questionario si sono ritenuti prioritari tre obiettivi: valutare il benessere psicologico e l’adattamento psicosociale del soggetto, valutare la probabilità che si verifichino condotte che potrebbero ledere il soggetto stesso o altre persone e valutare le risorse del soggetto per far fronte ad eventi avversi nella propria vita. La diagnosi dello stato di benessere e adattamento psicologico del soggetto è uno scopo prioritario per qualsiasi strumento di carattere clinico; inoltre, riferendosi ad una fascia d’età in piena evoluzione come quella della adolescenza o della giovinezza, diventa fondamentale poter raccogliere degli elementi che possano aiutare lo specialista a prevedere dei “comportamenti a rischio” da parte del soggetto. Alcool, droga, AIDS, incidenti stradali, teppismo, ecc. mettono seriamente a repentaglio la vita di moltissimi giovani o segnano invariabilmente la futura età adulta. Infine è necessario poter fare una stima della presenza delle cosiddette “strategie di coping”; le strategie di coping possono essere concettualizzate come delle risorse psicologiche che aiutano la persona ad elaborare ed affrontare le mutavoli situazioni che incontra nel corso della propria vita (Goldfried e Davison, 1976; Petter, 1999). Infatti, l’insufficiente acquisizione di tali strategie si traduce in difficoltà e problemi nel comportamento interpersonale e nella vita sociale dell’individuo. Per contro, aspettative realistiche di auto efficacia, la capacità di ristrutturare convinzioni erronee, un senso di fiducia nelle proprie capacità, abilità di problem solving, ecc., possono essere considerati dei veri e propri fattori “protettivi” della salute psicologica della persona e più in generale un indicatore di benessere e adattamento psicosociale. Descrizione del CBA-Y Il CBA-Y nella sua forma definitiva è composto da 500 item da compilare in forma checklist. Chi compila il questionario scorre i singoli item e segna la casella corrispondente a quelli che giudica possano adattarsi alla sua situazione. Questa modalità di risposta è giudicata in generale come meno invasiva perché consente l'omissione dell'item anziché forzare l'individuo a dare una risposta. Il tempo di compilazione si aggira attorno ai 30 minuti. Dal protocollo CBA-Y si ricavano tutta una serie di informazioni inerenti i singoli item marcati dall'esaminato. Inoltre è prevista la strutturazione delle riposte all'interno di 2 scale di controllo (Autoapertura, Stato Emotivo), 2 scale di benessere (Benessere, Adattamento psicosociale) e 7 scale di disagio (Uso di Droghe ed Esperienze Inusuali, Rischio Psicopatologico, Amore per il rischio e ricerca di sensazioni forti, Ansia e Instabilità Emotiva, Caratteristiche e comportamenti antisociali, irritabilità Aggressività Ostilità e Manifestazioni Psicofisiologiche). Viene inoltre calcolato il numero di item che sono stati usati per descriversi come ulteriore informazione per lo psicologo. Parallelamente è stata realizzata la forma breve dello stesso questionario, il CBA Benessere Giovanile (CBA-BG). La forma breve si differenzia dal questionario di base per la riduzione nel numero degli item che sono stati portati a 200. Dalle scale che vengono calcolate è stata eliminata quella relativa allo stato emotivo portandone il numero totale a 10. Obiettivi L’obiettivo globale della ricerca è validare il CBA forma Giovani. Il processo di validazione si articola in diversi momenti con differenti priorità. 1. Indagare le principali caratteristiche psicometriche del questionario. Si intende valutare la struttura fattoriale del questionario, la distribuzione dei punteggi nelle scale e la loro attendibilità, eventuali differenze di genere nelle risposte e eventuali differenze legate alle classi di età. 2. Validità convergente e discriminante: confronto dello strumento con altri questionari preposti allo screening psicologico della popolazione giovanile. 3. Validità di criterio: osservare i pattern di risposta al questionario di popolazioni caratterizzate dalla presenza di sintomatologie specifiche in ambito psicologico. 4. Misurare il potere predittivo del questionario verso l’insorgenza di sintomi psicopatologici nella popolazione giovanile. Partecipanti Un vasto campione rappresentativo della popolazione normale (circa 2000 partecipanti). Sottocampioni patologici per verificare la risposta del questionario se somministrato a individui critici. Un campione esterno a quello utilizzato per la raccolta dei dati normativi per testare la validità esterna del questionario. Materiali e metodo - Modulo di consenso informato - Cartella anagrafica (informazioni socio anagrafiche, anamnestiche e relative al trattamento farmacologico in corso) - Cartella clinica (informazioni relative alla diagnosi e al decorso della malattia) - CBA young form (CBA-Y) - CBA benessere giovanile (CBA-BG) - Minnesota Multiphasic Personality Inventory versione adolescenti (Butcher & Williams, 1996). I diversi partecipanti dovranno partecipare alla compilazione di uno o più questionari. Studio 1: analisi delle differenze tra la modalità di risposta "cheklist" e la modalità di risposta "vero o falso". Obiettivo. Gli obiettivi del presente lavoro sono due: valutare se la modalità checklist rispetto al vero/falso influenza i punteggi ed evidenziare eventuali differenze tra somministrazione cartacea ed elettronica. Metodo. 100 persone hanno compilato il questionario in modalità di risposta checklist e vero/falso in ordine controbilanciato. 50 persone hanno effettuato le due compilazioni in versione elettronica e 50 in versione cartacea. Per valutare le differenze tra le due modalità di risposta è stato utilizzato il test di McNemar sulle 16 sezioni del questionario e l’analisi della varianza sui punteggi ottenuti nelle 15 scale. Per valutare le differenze tra somministrazione cartacea ed elettronica è stata utilizzata l’analisi della varianza sui punteggi ottenuti nelle 15 scale. Risultati. Dal test di McNemar è emerso che il numero di item siglati “veri” è maggiore del numero di item selezionati nella checklist in tutte le sezioni del questionario esclusa la sezione “ansia di stato”. L’ANOVA ha evidenziato che i punteggi medi nelle scale del questionario sono più alti nella modalità di risposta “vero/falso” rispetto alla checklist. Non si sono riscontrate differenze tra la somministrazione cartacea e quella elettronica. Studio 2: validazione del CBA-Y. Obiettivo. Validare il questionario CBA-Y sulla popolazione italiana. Metodo. Per la validazione del CBA-Y sono stati reclutati 1732 ragazzi, 842 maschi (48,6%) e 890 femmine (51,4%) di età compresa tra 14 e 25 anni. E’ un gruppo di comunità, reclutato su base volontaria in scuole, luoghi di lavoro e altri contesti presumibilmente ‘normali’; il 92% risiede nel Nord-Italia. Ogni individuo è stato istruito circa la modalità di compilazione del questionario e ha accettato liberamente di prendere parte alla compilazione previo consenso informato. Durante la compilazione che poteva essere sia individuale sia di gruppo uno psicologo è sempre rimasto disponibile per gli eventuali chiarimenti inerenti il compito. I dati raccolti sono stati poi analizzati per ricavare i valori di soglia appartenenti a ciascuna scala del questionario suddivisi per genere e fasce d'età. L'affidabilità delle scale è stata indagata attraverso l'indice alfa di Cronbach (Cohen, 1988). La validità convergente (Campbell & Fiske, 1959) del questionario è stata analizzata mettendo in relazione il questionario con l'MMPI versione adolescenti. Risultati. Il questionario ha rivelato un buon grado di affidabilità e di validità interna. La relazione con l'MMPI si rileva coerente con quanto presente in letteratura. Studio 3: Applicazione del CBA-Y ad una popolazione clinica. Obiettivo. Indagare se il CBA-Y discrimina tra la popolazione normale e patologica. Metodo. Alla ricerca hanno preso parte 34 pazienti con diagnosi clinica in asse I e II. L'età media dell'intero campione è di 20,5 anni (range 14-26; Ds 3,66). All'interno del campione i ragazzi in trattamento sono stati divisi in 5 sottogruppi in base alla diagnosi principale: ansia, umore, personalità, disturbi dell'adolescenza e uso di sostanze. La somministrazione è avvenuta presso i servizi di Neuropsichiatria Infantile, o a domicilio dello sperimentatore su invio dello psicoterapeuta. Per indagare le differenze tra il campione normativo e il campione clinico è stato utilizzato il test t-student. Risultati. Dall'analisi dei dati emerge una buona capacità discriminante del CBA-Y nel distinguere la popolazione normale da quella clinica. Studio 4: Differenze tra i dati normativi e un campione di studenti francesi. Obiettivo. Questo studio vuole indagare come una popolazione diversa da quella italiana risponda al CBA-BG per indagarne gli aspetti di validità esterna. Metodo. La versione italiana del questionario (versione originale) è stata tradotta in francese e successivamente riportata nella lingua originaria (back traslation) in accordo con quanto suggerito nell'articolo di Brislin del 1970. Il questionario in lingua francese è stato somministrato all'interno della facoltà di psicologia di Nanterre (Paris Ouest) durante le pause tra le lezioni. Ogni studente ha compilato il questionario individualmente ed è stato preventivamente istruito a chiedere eventuali chiarimenti all'esaminatore. Hanno partecipato all'indagine 109 studenti (50 maschi; 45,9%) francesi di età compresa tra i 18 e i 24 anni. L'età media dei ragazzi era di 21,98 anni (ds=2,44) e quella delle ragazze era di 20,81 anni (sd=1,51). L'età tra i due generi si differenziava significativamente (F(1,107)=8,35; p<0,01). Tutti gli intervistati erano studenti universitari della facoltà di psicologia di Nanterre. Non vi è differenza statisticamente significativa tra il numero di ragazzi e di ragazze (χ2(1)=0.743; p=0.389). Analisi: per confermare la struttura fattoriale all'interno del campione francese sono stati utilizzati dei modelli di equazioni strutturali nella loro forma più semplice, l'analisi fattoriale confermativa (CFA). A causa delle scarsità del campione ogni scala del CBA-BG è stata valutata singolarmente in modo da ridurre la complessità del modello. Per indagare se vi fossero differenze tra le risposte del campione francese rispetto a quelle di un sottocampione appaiato estratto dai dati normativi è stata utilizzata l'analisi della varianza univariata utilizzando come fattori il genere e il gruppo (francesi e italiani). I risultati dell'analisi presi in esame sono l'interazione tra i fattori e l'effetto principale del gruppo. La prima esplicita la presenza di differenze tra le differenze di genere nei due gruppi mentre il secondo indaga l'eventuale differenza tra i gruppi. L'effetto principale del genere è irrilevante ai fini della presente ricerca. Risultati. L'analisi sul campione francese ha confermato la bontà del questionario per sette delle dieci scale analizzate. La soltanto parziale aderenza del modello ai dati originali è da attribuire alla natura stessa delle scale del CBA-BG. Esse non sono state ricavate tramite procedimenti statistici ma sono state pensate a livello teorico per indagare le differenti aree che in fase di stesura dello strumento erano state considerate utili per la pratica clinica. I due campioni presi in esame erano equivalenti sotto tutti gli aspetti salienti. Oltre che l'appaiamento per genere, età, scolarizzazione e condizione professionale essi non differivano nemmeno per le condizioni di somministrazione. Una variabile difficile da controllare in sede di analisi a cui spesso non si presta particolare attenzione durante la raccolta dei dati. L'analisi dei punteggi ottenuti nei due campioni non ha fatto emergere differenze sostanziali tra le scale del questionario. Solo la scala di benessere e il numero di item utilizzati per descriversi mostrano un punteggio significativamente minore nel campione francese rispetto a quello italiano. Possiamo concludere dicendo che i risultati di questo studio teso a generalizzare i dati ottenuti nella prima fase di validazione del questionario sono globalmente soddisfacenti.
Collins, Ronan. "'Client choice' : how some CBT therapists construct collaboration : implications for CBT and counselling psychology practice." Thesis, University of Roehampton, 2016. https://pure.roehampton.ac.uk/portal/en/studentthesis/client-choice-how-some-cbt-therapists-construct-collaboration--implications-for-cbt-and-counselling-psychology-practice(db45cd83-20bf-4c12-a917-256c04221ed1).html.
Повний текст джерелаChen, Wuyi. "The machining of hardened steel using superhard CBN tooling and CBN tipped rotary cutting tools." Thesis, University of Birmingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342395.
Повний текст джерелаBiffi, Marcelo. "Desenvolvimento do processo de retificação com alta velocidade em sede de válvulas de motores à combustão interna usando rebolo de CBN vitrificado." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18135/tde-12022016-144728/.
Повний текст джерелаThe aim of this work is to develop a high speed grinding process for super alloys using vitrified CBN wheels. For that, dressing conditions were studied in order to determine its influence on the CBN wheel performance. From the chosen parameters, the wheel wear and the ground surface quality were measured for different infeed speeds. A topographical mapping system based on acoustic emission was used to monitor the grinding process. As a result, the best dressing speed and speed ratio which generated the smallest surface roughness values could be found. The CBN wheel wear was measured and its ratio to the ground volume was evaluated. Through the mapping system, some visual patterns were obtained defining the grinding wheel behavior when dressing and grinding. Thus, the success vitrified CBN wheel application for super alloys depends basically on the wheel topography after dressing and the grinding parameters, which are dose related to the work material composition.
Rieck, Christian Marshall. "Segmentation of Medical Images Using CBR." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-8821.
Повний текст джерелаThis paper describes a case based reasoning system that is used to guide the parameters of a segmentation algorithm. Instead of using a fixed set of parameters that gives the best average result over all images, the parameteres are tuned to maximize the score for each image separately. The system's foundation is a set of 20 cases that each contains one 3D MRI image and the parameters needed for its optimal segmentation. When a new image is presented to the system a new case is generated and compared to the other cases based on image similarity. The parameters from the best matching case are then used to segment the new image. The key issue is the use of an iterative approach that lets the system adapt the parameters to suit the new image better, if necessary. Each iteration contains a segmentation and a revision of the result, and this is done until the system approves the result. The revision is based on metadata stored in each case to see if the result has the expected properties as defined by the case. The results show that combining case based reasoning and segmentation can be applied within image processing. This is valid for choosing a good set of starting parameters, and also for using case specific knowledge to guide their adaption. A set of challenges for future research is identified and discussed at length.
Jacobsson, Hampus. "Kalibrering och tillämpning utav CBD-modellen." Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58002.
Повний текст джерелаTurkington, Douglas. "Cognitive-behavioural therapy (CBT) for schizophrenia." Thesis, University of Newcastle upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271209.
Повний текст джерелаAlmström, Peter. "Three essays on transport CBA uncertainty." Licentiate thesis, KTH, Systemanalys och ekonomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-163355.
Повний текст джерелаQC 20150414
Miry, Erwan. "Similarité statistique pour le CBR textuel." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24972/24972.pdf.
Повний текст джерелаE-mails have recently become a popular mean of communication for exchanges between companies and their customers. However the increasing volume of messages makes manual processing difficult to achieve and automatic methods are foreseen as a more efficient solution. Automatic management systems help users in the processing of the messages and in the creation of a response from the messages kept in the company databases. One important question in this type of application is how to select existing e-mails to respond to a new request. The creation of new response messages requires texts pertaining to the new request topics. Finding similarity between documents is also an important task. Our goal for this research effort was to study how to detect similarity between small documents. To accomplish it, we followed a two-pronged approach: - finding similarity between words in order to augment a document’s vocabulary; - estimating similarity between documents, using all the similar words resulting from the previous step. We dedicated our work to determine the most interesting techniques to detect textual similarity between documents, and to improve those techniques using cooccurrences detection and lexical semantic similarity. During our experimentations, we tried different combinations, using cooccurrences detection and lexical similarity. We proposed techniques to augment the vocabulary of each message, based on different kind of reasoning to improve the estimation of similarity between documents. Our results indicate that the proposed augmentation techniques improve significantly the estimation of document similarity. The best results were obtained when using a combination of cooccurrences filter and cosine metric. However our experiments clearly indicate these results do not overcome the performance of similarity techniques based on tf*idf weights.
Vesali, Alireza [Verfasser], and Holger [Akademischer Betreuer] Reinecke. "Hochleistungs-/Hochgeschwindigkeitsschleifen mit laserstrukturierten CBN-Schleifscheiben." Freiburg : Universität, 2015. http://d-nb.info/112957265X/34.
Повний текст джерелаKerr, Jamie. "Allosteric modulation of the CB1 receptor." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196261.
Повний текст джерелаSato, Julio Noboru. "Crescimento homoepitaxial de GaAs por CBE." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/278462.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Fisica Gleb Wataghin
Made available in DSpace on 2018-07-21T20:30:43Z (GMT). No. of bitstreams: 1 Sato_JulioNoboru_M.pdf: 1907861 bytes, checksum: 9da572e0cf8e9f1e542ef7f2f309d976 (MD5) Previous issue date: 1996
Resumo: Apresentamos neste trabalho um estudo de crescimento homoepitaxial de GaAs que tem por objetivo calibrar o sistema CBE montado na Unicamp, auxiliando no crescimento de ligas ternárias e quaternárias. A escolha do crescimento de GaAs está baseada na sua grande importância em micro e optoeletrônica, assim como no fato de existir uma ampla referência bibliográfica sobre esta liga binária. Em nosso trabalho, mostramos que o modelo de Robertson e Donnelly pode ser usado para explicar o comportamento das taxas de crescimento obtidas. Mostramos, também, que a troca de marca do craqueador bem como a mudança da temperatura de craqueamento, influenciaram as características morfológicas, elétricas e de raio-X das amostras crescidas. Por fim, verificamos que as dopagens com silício e berílio, para as concentrações estudadas, são proporcionais a taxa de evaporação dos respectivos dopantes
Abstract: In this work we present a study on the growth of homoepitaxy of GaAs. Its goal is to calibrate the Chemical Beam Epitaxy system installed at this University, to help in the growth of ternary and quaternary alloys. The choice for GaAs growth was based on its importance for micro and optoelectronics, as well as on the existence of considerable amount of literature on this binary material. In our work we show that the model proposed by Robertson and Donnelly can be used to explain the behavior of the growth rate with respect to growth parameters. We also show that the use of two different cracker cells affected the morphological, electrical and crystallographic characteristics of the material. These characteristics were investigated as a function of the cracker cell temperature. Finally, we verified that Si and Be doping, for the doping levels considered in this study, are proportional to the evaporation rate of the sources used.
Mestrado
Física
Mestre em Física
Hagman, Sarah, and Julia Lindberg. "CBA of environmental projects within hydropower." Thesis, KTH, Energiteknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-246132.
Повний текст джерелаVattenkraften är en grundläggande pelare i det svenska energisystemet och står för en stor andel av den svenska elproduktionen på årsbasis. Vattenkraften har även hög betydelse för det svenska nätets balanseringsförmåga. Fortum är ett av de ledande energibolagen inom vattenkraft i Sverige och en viktig älv för dess kraftproduktion är Klarälven. Denna älv är dessutom fundamental för Klarälvslaxen och Klarälvsöringen och dess nödvändiga lekvandring. Under naturliga förhållanden ska den lekmogna laxen vandra uppströms Klarälven, men denna vandring försvåras av vattenkraftverken. Sedan 1930-talet har laxen transporterats uppströms Klarälven med lastbil för att nå sina lekområden, men när smolten och kelten ska vandra nedåt för att nå Vänern på nytt måste den passera de resterande åtta vattenkraftverken, vilket tillsammans med predation resulterar i en hög dödlighet. Två oberoende studier indikerar en överlevnad på 16 % respektive 30 %. För att stabilisera det vilda laxbeståndet föreslås en uppfångsanordning med nedströmstransport, där fisken fångas upp i en fälla och transporteras nedströms med lastbil. I juni 2016 beslutades det genom Energiöverenskommelsen att vattenkraften ska miljöanpassas och ett genomförande av en sådan fälla skulle möjligen kunna vara en sådan miljöanpassning. För att finna de mest lönsamma miljöanpassningarna inom vattenkraften bör samhällsekonomiska lönsamhetsbedömningar genomföras. En kostnadsnyttoanalys (CBA) är sådan bedömningsmetod där kostnader och nyttor genererade under projektets livstid ställs mot varandra. Genom projektet FRAM-KLIV har Energiforsk varit med och tagit fram ett CBA-verktyg som ska underlätta genomförandet av en sådan beräkningsanalys. CBA-verktyget användes som ram i det här examensarbetet där en kostnadsnyttoanalys gällande laxens förbättrade nedströmspassage genomfördes och utvärderades. Syftet med detta examensarbete har varit att undersöka huruvida detta CBA-verktyg skulle kunna användas i framtida prioriteringar under tillståndsprocesser för att hitta de mest lönsamma miljöanpassningarna. Dessutom skulle bakomliggande koncept och teori analyseras. Tillika skulle en utvärdering gällande lämpligheten i att värdera miljövärden i monetära termer utföras. I arbetet utformades totalt tretton scenarier, varav det första ansågs som grundscenariot och utgjorde basen för de övriga tolv, vilka skapades för att identifiera de mest kritiska parametrarna genom en känslighetsanalys. Kostnadsnyttoanalysens erhållna resultat tydde på en stor samhällsekonomisk lönsamhet och den mest kritiska parametern identifierades som människors betalningsvilja för en ökad vildlaxpopulation i Klarälven. Osäkerheten kring denna parameter var stor då den baserats på en annan projektundersökning i en annan del av landet. För att erhålla ett positivt samhällsekonomiskt resultat visade denna undersökning att det måste finnas en betalningsvilja på minst 35 kr per hushåll i Sverige. Som ett komplement till resultatet utfördes en beräkning gällande hur mycket varje smolt skulle behöva vara värd för att den samhällsekonomiska nyttan ska vara lika stor som kostnaden. Beräkningen gav ett intervall mellan 50 och 580 kr, men då använd data innehöll stora osäkerheter bör resultatet ses mer som en riktlinje och inte ett exakt resultat. En slutsats som kunde dras var att det anses lämpligt att uttrycka miljövärden i monetära värden när en samhällsekonomisk analys är nödvändig. CBA som metod anses också vara lämplig och användbar när större projekt ska analyseras eftersom den ger en bred bild över fördelningen mellan kostnader och nyttor. Metoden förser dessutom användaren med ett lättolkat och överskådligt resultat och därav skulle CBA som metod vara lämplig gällande prioritering av miljönyttor. Energiforsks CBA-verktyg kan underlätta processen i och med att det ger användaren en ram med riktlinjer för hur beräkningsprocessen ska gå till. Verktygsversionen som användes i detta examensarbete uppfyllde dock inte full tillfredsställelse vad gällde dess funktionalitet. Verktyget är visserligen fortfarande under utveckling och det är möjligt att dessa funktionsfel kommer att justeras i framtida versioner. Om dessa justeringar sker kan verktyget komma att bli fullt funktionsdugligt och vara användbart för myndigheter, företag och andra aktörer som vill utvärdera vattenkraftrelaterade miljöåtgärder eller som prioriteringsverktyg gällande miljöförbättringar inom framtida tillståndsprocesser.
Buitrago, Murcia Claudia Lorena. "Cbl proteins in platelet functional responses." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/198139.
Повний текст джерелаPh.D.
c-Cbl protein functions as an E3 ligase and scaffolding protein, where three residues, Y700, Y731, and Y774, upon phosphorylation, have been shown to initiate several signaling cascades. In this study, we investigated the role of these phospho-tyrosine residues in the platelet functional responses upon integrin engagement. We observed that c-Cbl Y700, Y731 and Y774 undergo phosphorylation upon platelet adhesion to immobilized fibrinogen, which was inhibited in the presence of PP2, a pan-src family kinase (SFK) inhibitor, suggesting that c-Cbl is phosphorylated downstream of SFKs. However, OXSI-2, a Syk inhibitor, significantly reduced c-Cbl phosphorylation at residues Y774 and Y700, without affecting Y731 phosphorylation. Interestingly, PP2 inhibited both platelet spreading on fibrinogen as well as clot retraction, whereas OXSI-2 blocked only platelet spreading, suggesting a differential role of these tyrosine residues. The physiological role of c-Cbl and Y731 was studied using platelets from c-Cbl KO and c-CblYF/YF knock-in mice. c-Cbl KO and c-Cbl YF/YF platelets had a significantly reduced spreading over immobilized fibrinogen. Furthermore, clot retraction with c-Cbl KO and c-Cbl YF/YF platelets was drastically delayed. These results indicate that c-Cbl and particularly its phosphorylated residue Y731 plays an important role in platelet outside-in signaling contributing to platelet spreading and clot retraction
Temple University--Theses
Giacometti, Simone. "CBC bound proteins and RNA fate." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS028.
Повний текст джерелаThe cap-binding complex (CBC) plays a pivotal role in post-transcriptional processing events and orchestrates a variety of metabolic pathways, through association with different interaction partners. Two CBC sub-complexes, the CBC-ARS2-PHAX (CBCAP) and the CBC-nuclear exosome targeting (NEXT) complex (CBCN), were recently shown to target capped RNA either toward export or degradation, but the mechanisms by which they can discriminate between different RNA families and route them toward different metabolic pathways still remain unclear. A major question to be answered is how and when the different CBC subcomplexes are recruited to the RNP. Here, we used an individual nucleotide-resolution UV cross-linking and immunoprecipitation (iCLIP) approach to identify the transcriptome-wide targets for 5 different components of the CBCAP and CBCN complexes, and compared results to the previously analysed NEXT-component RBM7. We report that: (i) CBP20, ARS2, PHAX and ZC3H18 bind close to the cap, while RBM7 and MTR4 bind throughout the mRNA body; (ii) CBP20, ARS2, PHAX and ZC3H18 associate with a broad set of RNA polymerase II (PolII)-derived RNAs and have only mild species preferences; (iii) binding varies with the RNA maturation stage, with the CBC being highly enriched on mature mRNA, ARS2/PHAX/ZC3H18/MTR4 less so, and RMB7 preferentially bound to pre-mRNAs; (iv) MTR4 and RBM7 show different specificities, with RBM7 being highly enriched on introns and promoter upstream transcripts (PROMPTs), while MTR4 is additionally present on mature RNAs. Although more experimental work is needed to fully support our model, we propose that CBCAP and CBCN bind overlapping sets of RNAs, indicating a competition between the proteins ZC3H18 and PHAX, and the lack of a strict RNA sorting mechanism. RNA fate may therefore be determined by additional RNA features and/or by other RNA-binding proteins, which may synergize with the cap and drive the formation of one specific CBC subcomplex instead of another. In an attempt to identify yet unknown factors that may interact with cap-bound CBCAP and CBCN, we performed a protein interaction screen leveraging affinity capture-mass spectrometry (ACMS), using ARS2 and CBP80 as bait proteins. As a complementary approach, we also employed a formaldehyde-based chemical cross-linking strategy, aimed at stabilizing weak/transient interactions. Although we failed to detect any transient interactions involving the CBC, we identified several potential CBC80 and ARS2 interactors, the majority of which are involved in pre-mRNA splicing. Additional quantitative experiments are required to validate our ACMS results and confirm the existence of such protein interactions in vivo
Durrant, Michael 1982. "Differential regulation of c-Cbl and Cbl-b ubiquitin ligases downstream of the Met receptor tyrosine kinase." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112619.
Повний текст джерелаIn this thesis work, I demonstrate a differential regulation of c-Cbl and Cbl-b downstream of the Met receptor tyrosine kinase. Cbl-b protein levels decrease in response to Met kinase activity, whereas c-Cbl levels remain stable. Cbl-b is partially degraded in a proteasome-dependant manner. This requires Cbl-b ubiquitin ligase activity and a carboxy terminal domain region located between the RING and UBA domains. I conclude that the regulation of c-Cbl and Cbl-b differs downstream of Met, and propose that negative regulation of Cbl-b by a dysregulated Met receptor may contribute to tumourigenesis.
Broussous, Sylvie. "Cystathionine β-synthase (CBS) et trisomie 21 : identification, synthèse et évaluation biologique de modulateurs de la CBS". Paris 11, 2008. http://www.theses.fr/2008PA114805.
Повний текст джерелаDown syndrome has a genetic basis: the presence in the genome of three rather than two chromosomes 21. This leads to gene dosage effects: involved genes and gene products are normal but their productions are increased. One enzyme, the Cystathionine b-Synthase (EC 4. 2. 1. 22, CBS) particularly interested us. The over expression of CBS directly disturbs the homocysteine metabolism and has special consequence: an overproduction of H2S. H2S is a well-known toxic gas but it is recently known as a neuromodulator in physiological concentrations. An overproduction of H2S was shown in the DS people’s brain. In view of all this information, the following hypothesis was advanced: a reversible inhibition of CBS activity could limit the metabolic disorders which are the origin of development of the intellectual retardation. This work consisted in carrying out significant in vitro enzymatic tests to detect, within libraries of chemicals, the presence of molecules having an inhibiting effect on the cystathionine β-synthase. More than 7000 molecules from different chemical libraries have been screened. 8 molecules belonging to three chemicals structures were able to inhibit reversibly and specifically the two enzymatic activities assays: pure recombinant human CBS and extracts from rat livers. We determined by means of dose-response curve theirs IC50 and the possible action site of molecules on the enzyme. In a second time, pharmacomodulations were realized for each family of molecules (coumarine, pyridazine and benzothiophen) in the purpose of improving the inhibitive power of « hits »
Gunn, Anthony. "The automated CBT psychologist: the development and trial of an online cbt treatment program for stuttering adolescents." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12745.
Повний текст джерелаMora, Carlos A. "Comparison of computation methods for CBM production performance." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1958.
Повний текст джерелаMarthinsen, Tor Henrik Aasness. "Conversational CBR for Improved Patient Information Acquisition." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-8803.
Повний текст джерелаIn this thesis we describe our study of two knowledge intensive Conversational Case-Based Reasoning (CCBR) systems and their methods. We look in particular at the way they have solved inferencing and question ranking. Then we continue with a description of our own design for a CCBR system, that will help patients share their experiences of side effects with drugs, with other patients. We describe how we create cases, how our question selection methods work and present an example of how the domain model will look. It is also included a simulation of how a dialogue would be for a patient. The design we have created is a good basis for implementing a knowledge intensive CCBR system. The system should work better than a normal CCBR system, because of the inferencing and question ranking methods, which should lessen the cognitive load on the user and require fewer questions answered, to reach a good solution.
Delvecchio, Manuela. "Mécanisme de régulation de l'acétyltransférase p300/CBP." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00631344.
Повний текст джерелаFujiki, Kazuhiko. "A study on CBD land value variations." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27261.
Повний текст джерелаBusiness, Sauder School of
Graduate
Yau, Arnold K. L. "Side channel analyses of CBC mode encryption." Thesis, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537515.
Повний текст джерелаPelletier, Hubert. "Mise au point d'un réacteur épitaxial CBE." Mémoire, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5944.
Повний текст джерелаTakkinen, V. M. (Veli-Matti). "Soratien kantavuuden määrittäminen laboratoriossa CBR- ja kolmiaksiaalikokeella." Bachelor's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201809182809.
Повний текст джерелаDeclining conditions in Finland’s gravel roads have been hot topic for a while. One part of gravel road maintenance is to find out loading capacity of the road. To define loading capacity, material conditions, situational features and stress state needs to be defined. Factors affecting material conditions are among other things maximum grain size, grading curve and fine content. Factors describing situational features are for example tightness, frost-melt cycle and moisture content. Stress state is defined by deformation features in field survey and laboratory tests. CBR- and Triaxial compression tests are most used laboratory tests to determine deformation features. Deformation modulus is received as a result from both tests. Modulus can be used to define loading capacity of gravel road. Objective of this thesis is to find out differences between CBR- and Triaxial compression tests and give recommendations which test to use at given situation. Thesis is performed as a literature review. In addition, author does CBR- and grading curve tests as a practical part in Geotechnical Laboratory of University of Oulu. Based on literature review, no precise boundaries can be given for method selection. Both CBR- and Triaxial compression tests are very dependent on how well specimen represents real conditions. In both tests, large grains may need to be removed to construct specimen. In this case, representativeness of the specimen declines. In CBR-test, the result is a CBR value, which is then compared to standard CBR value. In Triaxial test, the test results are stress parameters, which are used to determine cohesion and angle of friction of specimen. In CBR-test, specimen is compressed uniaxially, where as in Triaxial test specimen is compressed triaxially. Triaxial test doesn’t take into consideration twisting of stresses which becomes a problem
Klein, Fabrice. "Etudes structurales des interactions CBP-récepteurs nucléaires." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13241.
Повний текст джерелаNuclear receptors form a large family of transcription factors, whose activities are often controled by the fixation of small ligands. Binding to an agonist ligand allows the recruitment of transcriptional coactivators, like the p300/CREB‑BindingProtein (p300/CBP) or the p160/Steroid‑Receptor‑Coactivator (p160/SRC). Those coactivators possess several LxxLL motifs (L = Leucine ; X = any aminoacid), mainly responsible for the interaction with NRs. We characterized the aminoterminal (Nter) domain of CBP responsible for the interaction with NR Ligand Binding Domains (LBDs) and cocrystallized it together with the Peroxisome Proliferator‑Activated Receptor gamma LBD (lbd‑PPARg). The poor diffraction properties of the crystals did not allow us to solve the structure of this (Nter-CBP/lbd-PPARg) complex. Nuclear Magnetic Resonance (NMR) experiments demonstrate that Nter-CBP is poorly structured on its own. Its interaction with the LBDs of 3 different NRs - PPARg, Retinoid X Receptor alpha (RXRa) and Estrogen Related Receptor gamma (ERRg) – was studied by NMR. The structure of CBP in complex with any of these LBDs could not be solved, because of a strong signal attenuation of the residues implied in the interaction. Nevertheless, the aminoacids of CBP that interact with those 3 NRs could be mapped by this technique : they correspond to 2 discontinuous zones, delimited by the aminoacids (31 to 38) and (61 to 80), the latter containing the LxxLL motif. We also studied the interaction between CBP or SRCs fragments with lbd-PPARg and lbd-RXRa, in a comparative manner, by surface plasmon resonance and native electrophoresis. Our results show that CBP interacts preferentially with PPARg, whereas SRCs show a better affinity towards RXRa. We suggest that CBP might be directly recruited by PPARg/RXRa, which could play a role in the permissivity of this heterodimer
Leary, James E. "Conflict management style in selected CBA churches." Theological Research Exchange Network (TREN), 1999. http://www.tren.com.
Повний текст джерелаSuntharakumaran, Vino [Verfasser]. "Profilschleifen mit sintermetallischen CBN-Schleifscheiben / Vino Suntharakumaran." Garbsen : TEWISS - Technik und Wissen GmbH, 2020. http://d-nb.info/1205502351/34.
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