Добірка наукової літератури з теми "Cationic Amphiphilic Peptides"
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Статті в журналах з теми "Cationic Amphiphilic Peptides"
Silva Nigenda, Ezequiel, Tobias M. Postma, Mohammed Hezwani, Alin Pirvan, Susan Gannon, Carol-Anne Smith, Mathis Riehle, and Rob M. J. Liskamp. "Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides." MedChemComm 9, no. 6 (2018): 982–87. http://dx.doi.org/10.1039/c8md00113h.
Повний текст джерелаAkkarawongsa, Radeekorn, Terra B. Potocky, Emily P. English, Samuel H. Gellman та Curtis R. Brandt. "Inhibition of Herpes Simplex Virus Type 1 Infection by Cationic β-Peptides". Antimicrobial Agents and Chemotherapy 52, № 6 (7 квітня 2008): 2120–29. http://dx.doi.org/10.1128/aac.01424-07.
Повний текст джерелаSchweizer, Frank. "Cationic amphiphilic peptides with cancer-selective toxicity." European Journal of Pharmacology 625, no. 1-3 (December 2009): 190–94. http://dx.doi.org/10.1016/j.ejphar.2009.08.043.
Повний текст джерелаFindlay, Brandon, George G. Zhanel, and Frank Schweizer. "Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold." Antimicrobial Agents and Chemotherapy 54, no. 10 (August 9, 2010): 4049–58. http://dx.doi.org/10.1128/aac.00530-10.
Повний текст джерелаKaconis, Yani, Ina Kowalski, Jörg Howe, Annemarie Brauser, Walter Richter, Iosu Razquin-Olazarán, Melania Iñigo-Pestaña, et al. "Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides." Biophysical Journal 100, no. 11 (June 2011): 2652–61. http://dx.doi.org/10.1016/j.bpj.2011.04.041.
Повний текст джерелаCao, Meiwen, Yuming Wang, Xin Ge, Changhai Cao, Jing Wang, Hai Xu, Daohong Xia, Xiubo Zhao, and Jian R. Lu. "Effects of Anions on Nanostructuring of Cationic Amphiphilic Peptides." Journal of Physical Chemistry B 115, no. 41 (October 20, 2011): 11862–71. http://dx.doi.org/10.1021/jp205987w.
Повний текст джерелаWiradharma, Nikken, Ulung Khoe, Charlotte A. E. Hauser, See Voon Seow, Shuguang Zhang та Yi-Yan Yang. "Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents". Biomaterials 32, № 8 (березень 2011): 2204–12. http://dx.doi.org/10.1016/j.biomaterials.2010.11.054.
Повний текст джерелаKundu, Rajen. "Cationic Amphiphilic Peptides: Synthetic Antimicrobial Agents Inspired by Nature." ChemMedChem 15, no. 20 (September 8, 2020): 1887–96. http://dx.doi.org/10.1002/cmdc.202000301.
Повний текст джерелаRideout, Darryl C., Michael Lambert, Debra A. Kendall, Gregory R. Moe, David G. Osterman, H. P. Tao, I. Bernard Weinstein, and E. T. Kaiser. "Amphiphilic cationic peptides mediate cell adhesion to plastic surfaces." Journal of Cellular Physiology 124, no. 3 (September 1985): 365–71. http://dx.doi.org/10.1002/jcp.1041240302.
Повний текст джерелаStrandberg, Erik, Deniz Tiltak, Marco Ieronimo, Nathalie Kanithasen, Parvesh Wadhwani та Anne S. Ulrich. "Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic α-helical peptides". Pure and Applied Chemistry 79, № 4 (1 січня 2007): 717–28. http://dx.doi.org/10.1351/pac200779040717.
Повний текст джерелаДисертації з теми "Cationic Amphiphilic Peptides"
Reijmar, Brunnström Karin. "Development of lipodisks as carriers for cationic amphiphilic peptides." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-305443.
Повний текст джерелаSilva, Nigenda Ezequiel. "Synthesis of drug delivery systems based on pantothenic acid and cationic amphiphilic peptides modifications." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8917/.
Повний текст джерелаFindlay, Brandon. "Design and synthesis of cationic amphiphiles." American Society for Microbiology, 2010. http://hdl.handle.net/1993/21708.
Повний текст джерелаShyam, Radhe. "Cationic amphipathic peptoid oligomers as antimicrobial peptide mimics." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAC048/document.
Повний текст джерелаLiving organisms produce antimicrobial peptides (AMPs) to protect themselves against microbes.The growing problem of antimicrobial resistance calls for new therapeutic strategies and the natural AMPs have shown ground-breaking potential to address that issue. They show broad-spectrum activity and their main mechanism of action by bacterial cell membrane disruption implies low emergence of resistance which makes them potent candidates for replacing conventional antibiotics. Nevertheless, few hurdles are impeding their use, notably poor bioavailability profile. Some of these limitations can be overcome by developing peptidomimetics of AMPs which exhibit antibacterial activities together with enhanced therapeutic potential. Peptoids (i.e. N-alkyl glycine oligomers) adopting cationic amphipathic helical structures are mostly competent AMP mimetics. From a conformational point of view, peptoids are fundamentally more flexible than peptides primarily due to the cis/trans isomerism of N,N-disubstituted amides but studies in this area have shown that cis amide conformation can be controlled by careful choice of side-chain to set a PolyProline I-type helical structure of peptoids. In this thesis, the genesis of novel amphipathic cationic peptoids carrying cis-directing tert-butyl and/or triazolium-type side-chains and their untapped potential to act against bacteria will be discussed comprehensively. First, the solutionphase synthesis of tert-butyl-based oligomers was developed. Second, novel method of solid-phase submonomer synthesis was optimised to access 1,2,3-triazolium-based oligomers. Then, the synthesised cationic oligomers were evaluated for their antibacterial potential, followed by antibiofilm activity and cell selectivity assays. In the end, to have insights on the mode of action of amphipathic peptoids, microscopy was carried out
Ahmad, Roni Oda Reiko. "Oligo-peptides confinés à la surface de membranes d'amphiphiles cationiques." S. l. : Bordeaux 1, 2008. http://ori-oai.u-bordeaux1.fr/pdf/2008/AHMAD_RONI_2008.pdf.
Повний текст джерелаAhmad, Roni. "Oligo-peptides confinés à la surface de membranes d'amphiphiles cationiques." Thesis, Bordeaux 1, 2008. http://www.theses.fr/2008BOR13697/document.
Повний текст джерелаAbstract
(10010291), Samantha Mae Zeiders. "EXPLORING ANTIBIOTIC CONJUGATION TO CATIONIC AMPHIPHILIC POLYPROLINE HELICES." Thesis, 2021.
Знайти повний текст джерелаPathogenic bacteria present a critical threat to modern medicine. Therapeutic strategies to target and eliminate resilient bacteria are not advancing at the same rate as the emergence of bacterial resistance. An associated urgent concern regarding antibiotic resistance is the existence and proliferation of intracellular bacteria, which find refuge from bactericidal mechanisms by hiding within mammalian cells. Therefore, many once-successful antibiotics become ineffective through the development of resistance, or through failure to reach intracellular locations in therapeutic concentration. To overcome these challenges, the covalent combination of a conventional antibiotic with an antibiotic, cell-penetrating peptide was explored to develop dual-action antibiotic conjugates.
Herein, we utilized a strategy in conjugating the antibiotics by a cleavable linkage to cationic amphiphilic polyproline helices (CAPHs) to improve vancomycin and linezolid antibiotics. This approach enables the conjugate to penetrate cells and deliver two potent monomeric antimicrobial drugs. The vancomycin-CAPH conjugate, VanP14S, showed enhanced mammalian cell uptake compared to vancomycin, a poor mammalian cell-penetrating agent; and VanP14S was capable of cleaving and releasing two antibiotics under mimicked physiological conditions. Enhanced antibacterial activity was observed against a spectrum of Gram-positive and Gram-negative pathogens, including drug-resistant strains. Further investigation revealed that this conjugate’s bactericidal activity was not entirely the result of significant membrane perturbation such as a lytic mode of action. Mammalian cell toxicity and red blood cell lysis were insignificant at relevant bactericidal concentrations below 20 µM. The current results suggest an enhanced binding to the peptidoglycan of bacteria, the target of vancomycin, although more work is needed to justify this claim. Preliminary results on VanP14GAPS, a conjugate with a more rigid CAPH, convey similar activity to VanP14S; however, moderate increases in red blood cell lysis and cytotoxicity were observed.
Regarding the LnzP14 conjugate, preliminary data reveal that the conjugate has Gram-negative activity against Escherichia coli, whereas linezolid is ineffective in killing Gram-negative bacteria. This conjugate showed significant enhancement in cellular uptake compared to the CAPH, and the release of linezolid and CAPH in physiological conditions was confirmed. Overall, arming a conventional antibiotic with an antimicrobial, cell-penetrating peptide appears to be a powerful strategy in providing novel antibiotic conjugates with the propensity to overcome the limitations in treating challenging pathogens.
Maumela, Pfariso. "The study of cationic amphiphilic peptides with anti-cancer selective toxicity." Thesis, 2014. http://hdl.handle.net/10539/15330.
Повний текст джерелаThe exposure of organisms to environmental stresses and pathogens results in rapid activation of a range of defensive pathways that act as part of the innate immune system. The most common innate immunity response is the activation of cationic amphiphilic peptides in response to microbial infection. Moreover, cationic amphiphilic peptides possess desirable attributes for the pharmaceutical development of cancer-selective drugs. They selectively and rapidly kill cancer cells without killing normal mammalian cells and have a broad spectrum of mechanisms of action. The aim of this exploratory study was to screen for cationic amphiphilic peptides with anti-proliferative activity that is induced by genotoxicity. GeneFishing® technology, 2-D gel analysis and bioassays were used to identify and analyse molecules induced in response to genotoxic stress in an embryonic cell line originating from the dung beetle Euoniticellus intermedius. Bioassay results revealed that the cell line has constitutive expression of probable cationic amphiphilic proteins that are further induced by camptothecin treatment. GeneFishing® and 2-D gel analysis showed changes in gene expression at both transcriptional and translational levels, respectively. Overall, the study failed to identify the involvement or induction of cationic amphiphilic peptides in response to genotoxic stress. However, gene expression analyses revealed changes in the expression of classes of proteins involved in stress response, oxidative phosphorylation, mitochondrial maintenance, protein translation, cytoskeletal proteins and immunophilins. The results show that the cell line constitutively expresses probable cationic amphiphilic peptides which are further induced by camptothecin.
Arnt, Lachelle. "Cationic facially amphiphilic phenylene ethynylenes as host defense peptide mimics." 2005. https://scholarworks.umass.edu/dissertations/AAI3179853.
Повний текст джерела(11014752), Ambar M. Rosario. "Synthesis of a Cationic Amphiphilic Polyproline Helix (CAPH) Conjugate with Polymyxin B." Thesis, 2021.
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