Дисертації з теми "Care cascade"

The Human Immunodeficiency (HIV) epidemic in South Africa is disproportionately distributed by gender. Although women lead in the number of infections they are at an advantage when it comes to seeking and receiving care. Men's poor health seeking behaviour finds them seeking care late, testing at lower rates, defaulting from treatment and eventually having worse health outcomes. More men than women fail to enter and stay in the HIV cascade of care. The HIV cascade is a metaphor used to describe the steps that include HIV testing, initiation of antiretroviral therapy (ART), adherence, viral suppression and good health outcomes. As health care providers (HCPs) are the ones who interact directly with men in the health system their view of the factors that hinder men's movement through the HIV cascade are valuable to better understanding how men interact with the care system. In this research semi-structured interviews were held with eleven HCPs working with HIV positive patients (6 women, 5 men) across 2 health facilities and 1 non-governmental organisation (NGO) within the Klipfontein sub-district. Health care workers were found to share some of the more commonly held notions regarding the barriers men face in HIV care. However, their experiences offer some challenging ideas and the health systems appears to be realising the need to tailor HIV services to the needs of men. The experiences and perspectives of HCPs should be further explored and the findings used to influence health policies and clinical practice.

Introduction : L’Organisation mondiale de la Santé a fixé un objectif d’élimination des hépatites C et B à l’horizon 2030, visant à ce que 90% des personnes ayant une infection chronique soient diagnostiquées et 80% soient traitées. La France s’est engagée à atteindre cet objectif pour l’hépatite C d’ici 2025. Ce travail a pour but d’estimer la cascade de prise en charge de l’hépatite C chronique en France métropolitaine : 1) en 2016, afin de disposer d’un premier point pour le suivi de l’élimination ; 2) en 2011, afin d’évaluer l’impact des antiviraux à action directe (AAD) sur la cascade.Méthodes : Les effectifs des populations suivantes ont été estimés pour 2016 (18-75 ans) et 2011 (18-80 ans) : 1) ayant une hépatite C chronique ; 2) ayant connaissance de leur infection ; 3) prises en charge pour leur infection au cours de l’année ; 4) en cours de traitement antiviral au cours de l’année. Les estimations 1) et 2) reposent : pour 2016, sur une enquête transversale, avec un volet biologique, réalisée auprès d’un échantillon aléatoire de la population générale métropolitaine ; pour 2011, sur des modélisations. Les estimations 3) et 4) ont été réalisées à partir du Système national des données de santé (SNDS), en : i) construisant, pour 3), un algorithme d’identification des personnes avec au moins un recours aux soins pour une hépatite C chronique dans l’année ; ii) prenant en compte l’ensemble des traitements antiviraux contre l’hépatite C pour 4).Résultats : Entre 2011 et 2016, le nombre de personnes ayant une hépatite C chronique a diminué de 31%, passant de 192 700 à 133 500. Le nombre de personnes ayant connaissance de leur infection est resté stable : 111 300 en 2011 et 107 600 en 2016. La proportion de personnes infectées ayant connaissance de leur infection est donc passée de 58% à 81%. Entre 2011 et 2016, le nombre de personnes identifiées comme prises en charge pour leur hépatite dans l’année est passé de 28 000 (15% des personnes infectées) à 34 300 (26% des personnes infectées). Parallèlement, le nombre de personnes en cours de traitement est passé de 12 900 (7% des personnes infectées) en 2011 à 16 100 en 2016 (12% des personnes infectées.Conclusion : Ce travail a permis, pour la première fois, d’estimer la cascade de prise en charge de l’hépatite C chronique en France métropolitaine, avant et après l’introduction des AAD. Il suggère un impact important de ceux-ci sur la cascade de soins. Pour autant, l’accès aux soins et au traitement des personnes infectées restait insuffisant en 2016, notamment au regard des objectifs d’élimination
Introduction: The World Health Organization has targeted the elimination of hepatitis C and B by 2030, to ensure that 90% of people with chronic infection are diagnosed and 80% are treated. France has planned to achieve this goal for hepatitis C by 2025. This work aims to estimate the cascade of care for chronic hepatitis C in mainland France: 1) in 2016, in order to have a first point for monitoring the elimination; 2) in 2011 to assess the impact of direct-acting antivirals (DAAs) on HCV cascade of care.Methods: The numbers of the following populations were estimated for 2016 (18-75 years) and 2011 (18-80 years): 1) with chronic hepatitis C; 2) aware of their infection; 3) in care for chronic hepatitis C during the year; 4) undergoing antiviral treatment during the year. Estimates 1) and 2) were based on: for 2016, a cross-sectional survey, with a biological component, carried out on a random sample of the general metropolitan population; for 2011, on models. Estimates 3) and 4) were made from the National Health Insurance Information System (SNDS), by: i) constructing, for 3), an algorithm for identifying people in care for chronic hepatitis C in the year; ii) taking into account all antiviral treatments for 4).Results: Between 2011 and 2016, the number of people with chronic hepatitis C decreased by 31%, from 192,700 to 133,500. The number of people aware of their infection remained stable: 111,300 in 2011 and 107,600 in 2016. The proportion of chronically infected persons with knowledge of their infection has thus increased from 58% to 81%. Between 2011 and 2016, the number of people identified as being in care for their hepatitis in the year increased from 28,000 (15% of those infected) to 34,300 (26% of those infected). At the same time, the number of people being treated increased from 12,900 (7% of those infected) in 2011 to 16,100 in 2016 (12% of those infected).Conclusion: This work provides, for the first time, estimates of the cascade of care for chronic hepatitis C in mainland France, before and after the introduction of DAAs. It suggests a significant impact of DAAs on the cascade of care. However, access to care and treatment for infected people remained insufficient in 2016, especially with regard to elimination targets

Background: The incidence of tuberculosis (TB) among Inuit is over 400 times that of Canadian-born non-indigenous people. To address this, more patients will need to complete preventative treatment. Methods: First, data were extracted retrospectively for all patients with a tuberculin skin test (TST) implanted in Iqaluit, Nunavut between January 2012 and March 2016 and used to identify sources of loss from the latent TB infection (LTBI) cascade of care. Associations between demographic and clinical factors and treatment non-initiation and treatment non-completion were identified using regression models. Second, using a slightly expanded version of the retrospective dataset plus other sources, a Markov model was utilized to assess the cost-effectiveness of a novel shortened regimen for LTBI (12 weeks of once weekly isoniazid and rifapentine (3HP)) compared to the current standard of care (9 months of isoniazid monotherapy (9H)). Results: Treatment non-initiation and non-completion were the largest sources of loss of TST positive patients from the cascade of care. LTBI testing via employment screening was associated with treatment non-initiation while older age was associated with both treatment noninitiation and non-completion. In cost-effectiveness analysis, 3HP was dominant over 9H: costs were lower ($835 vs $1229 per person) and health outcomes slightly improved (20.14 vs 20.13 QALYs gained per person treated), largely due to an improved treatment completion with 3HP. Conclusions: Interventions to increase LTBI treatment initiation and completion in Iqaluit are needed. This could include the use of 3HP instead of 9H for LTBI treatment which may improve treatment completion and result in cost savings and slightly improved health outcomes.

Rationale Epilepsy is a common, chronic, neurological condition that disproportionately affects individuals living in low- and middle- income countries, including much of sub-Saharan Africa. Epilepsy is treatable, with the majority of individuals who take anti-epileptic drugs experiencing a reduction, or elimination, of seizures. Yet the number of individuals taking and adhering to medication in Africa is low and interventions aimed at improving treatment are lacking. Aims To define the epidemiology of convulsive epilepsy in rural South Africa in terms of incidence, mortality and disability-adjusted life years; to determine outpatient, out-of-pocket costs resulting from epilepsy treatment; to establish the level of adherence to anti-epileptic drugs amongst people with epilepsy; and, to determine whether the introduction of routine visits to people with epilepsy by community health workers is a cost-effective intervention for improving adherence to anti-epileptic drugs. Methods Nested within the Agincourt Health and Demographic Surveillance System, this work utilized a cohort of individuals diagnosed with convulsive epilepsy in 2008 to determine health care utilization and out-of-pocket costs due to care sought for epilepsy. Additionally, using blood samples from the cohort, anti-epileptic drug adherence was measured and, following the cohort, mortality rates were determined. Using these collected epidemiological parameters, disability-adjusted life years due to convulsive epilepsy were determined. Finally, combining the epidemiological and cost parameters, a community health worker intervention was modeled to determine its incremental cost-effectiveness ratio. Key Findings The burden of convulsive epilepsy is lower in rural South Africa than other parts of Africa, likely due to lower levels of known risk factors. Yet the burden, especially in terms of mortality, remains high, as does the treatment gap and health care utilization. Findings from the economic evaluation found the introduction of a community health worker to be highly cost-effective and would likely lower the burden of epilepsy in rural South Africa. Implications Epilepsy contributes to the burden of disease in rural South Africa, with high levels of mortality and a substantial treatment gap. The introduction of a community-health worker is likely to be one cost-effective, community based intervention that would lower the burden of epilepsy by improving adherence to anti-epileptic drugs. Implementing this intervention, based on these findings, is a justified and important next step.

L'objectif de cette thèse est de clarifier le rôle de la composante rotationnelle de la force de Lorentz dans sa capacité à imposer la topologie, et la dynamique des écoulements turbulents MHD à bas Rm, confinés par des parois rigides et électriquement isolantes. Le travail présenté ici se scinde en deux parties : D'une part une étude théorique effectuée dans un cadre faiblement inertiel, d'autre part une étude expérimentale d’écoulements turbulents pleinement développés. L’étude théorique porte sur un vortex isolé, stationnaire et axisymétrique, confiné entre deux parois rigides et électriquement isolantes, perpendiculaires à un champ magnétique uniforme. Grâce à un développement asymptotique des équations de Navier-Stokes, valable quel que soit le nombre de Hartmann, nous montrons que la dimensionnalité topologique de l’écoulement de base ne dépend que d'un seul paramètre. Ce paramètre en question compare en fait la distance sur laquelle la partie rotationnelle de la force de Lorentz est capable d'agir dans la direction du champ magnétique, avant d’être contrée par les effets visqueux. Cette étude met en lumière deux mécanismes inertiels capables d'engendrer une composante de la vitesse dans la direction du champ magnétique au premier ordre, en introduisant des recirculations dans le plan méridional : du pompage d'Ekman direct ou inverse. Un dispositif expérimental à également été construit durant ce projet, afin d’étudier la dynamique d’écoulements turbulents de métaux liquides soumis à des champs magnétiques intenses. La turbulence stationnaire engendrée par ce dispositif était forcée électriquement en imposant un courant continu à travers une matrice carrée et periodique d’électrodes d'injection. Grâce à ce dispositif, nous avons montré que les statistiques des fluctuations turbulentes étaient raisonnablement homogènes et axisymétriques, malgré un forçage inhomogène et anisotrope. Nous confirmons également, en comparant les densités d’énergie cinétique turbulentes mesurées le long des parois perpendiculaires au champ magnétique, que les processus physiques en jeu dans le domaine inertiel 3D de la turbulence MHD confinée à bas Rm sont bien la composante rotationnelle de la force de Lorentz d'une part, et les transferts inertiels d'autre part. Grâce à une étude statistique dans l'espace des échelles, nous montrons que la cinématique de la turbulence forcée dans notre expérience suit en fait une loi universelle qui ne dépend que de deux longueurs caractéristiques. Premièrement, l’échelle d'injection, dans la direction perpendiculaire au champ magnétique. Deuxièmement, le rayon d'action de la force de Lorentz avant d’être contrée par les effets inertiels, dans la direction parallèle au champ. Nous prouvons que le rapport entre cette dernière longueur caractéristique et la hauteur de l'enceinte expérimentale permet de différencier les structures turbulentes cinématiquement quasi-2D de celles qui sont cinématiquement 3D. En calculant directement le flux d’énergie cinétique turbulente perpendiculaire à travers les échelles horizontales, nous montrons que ce dernier est toujours dirigé vers les grandes échelles. Ce quel que soit la dimensionnalité des échelles en question. Autrement dit, une cascade inverse d’énergie perpendiculaire peut exister sans pour autant que les structures turbulentes associées soient quasi-2D
This thesis aims at clarifying the role of the solenoidal component of the Lorentz force in fixing the topological dimensionality, and the ensuing dynamics of low-Rm MHD turbulent flows confined between electrically insulating and no-slip Hartmann walls. The work presented here breaks down into two main parts: An analytical investigation carried out in the weakly inertial limit on the one hand, and an experimental study of fully developed turbulence on the other hand. The analytical investigation was performed on a single steady and axisymmetric electrically driven vortex confined between no-slip and electrically insulating walls perpendicular to a uniform magnetic field. Thanks to an asymptotic expansion valid for any Hartmann number, we showed that the topological dimensionality of the leading order is fully imposed by a single parameter, which compares the distance over which the Lorentz force is able to act in the direction of the magnetic field, before it is balanced out by viscous friction. This study highlights two inertial mechanisms capable of introducing a third velocity component in the direction of the field, by means of recirculations in the meridional plane: direct and/or inverse Ekman pumping. An experimental platform was designed and built from the ground up during this project, to investigate the dynamics of liquid metal turbulence subject to extreme magnetic fields. The turbulence sustained in our experiment was forced electrically by imposing a DC current through a square periodic array of electrodes. Thanks to this setup, we showed that the statistics of the turbulent fluctuations were homogeneous and axisymmetric to a satisfactory level, despite the forcing mechanism being inhomogeneous and anisotropic. By comparing the energy densities measured along the walls perpendicular to the magnetic field, we confirm that the physical processes at stake in the 3D inertial range of wall-bounded MHD turbulence at low-Rm are the solenoidal component of the Lorentz force on the one hand, and inertia on the other hand. Thanks to a statistical analysis in scale space, we show that their exists a universal law imposing the kinematics of turbulent structures in our experiment, which turns out to be fully described by only two lenghtscales. First, the forcing scale in the direction perpendicular to the magnetic field. Second, the range of action of the Lorentz force before it is balanced out by inertial transfers, in the direction parallel to the field. We prove that the ratio of this latter scale over the height of the channel in fact segregates kinematically quasi-2D from kinematically 3D turbulent structures. By computing the actual flux of perpendicular turbulent kinetic energy along perpendicular scales, we show that it always flows towards larger turbulent scales regardless of their topology. In other words, we show that the existence of an inverse cascade of perpendicular kinetic energy does not necessarily require perpendicular turbulent scales to be topologically quasi-2D in the inertial range

Trophic interactions within aquatic ecosystems are complex, with many different pathways facilitating transfer of energy and nutrients among trophic levels and many different mechanisms that influence energy and nutrient transfer. This is illustrated in the “top down” and “bottom up” regulatory effects on aquatic food webs, through which primary producer biomass and, therefore, herbivore and carnivore densities, are influenced by both nutrient availability (bottom up) and densities of consumers at higher trophic levels (top down). In an aquatic food web, planktivore presence can directly alter zooplankton density via consumption, while indirectly shaping phytoplankton biomass via reduced herbivore abundance and the release of nutrients due to excretion, egestion, and decomposition. Novel species introduced into an established food web may have important consequences. An invasive species may impact an invaded food web through competition, predation, alteration of nutrient cycling, or, potentially, through facilitation of native species or other invasives. For example, an invasive planktivore may shift zooplankton density or community composition, thereby facilitating phytoplankton blooms. Such a planktivore may also compete with and, potentially, replace native species. Moreover, an invasive species that reaches high densities within its invaded range may serve as an important nutrient sink as it consumes a high biomass of native species or a nutrient source via excretion or decomposition. Two such invasive species with the capacity to dramatically alter native food web dynamics are bighead (Hypophthalmichthys nobilis) and silver carp (H. molitrix; collectively, bigheaded carp). Bigheaded carp are large-bodied, planktivorous fishes that were introduced into the United States in the 1970s and have since spread throughout much of the Mississippi River and its tributaries. These species currently threaten the Great Lakes, where they may constitute a threat to native planktivores such as gizzard shad (Dorosoma cepedianum) and commercially important species such as walleye (Sander vitreus), although there remains a great deal of uncertainty surrounding their potential ecosystem impacts. Consumption of both zooplankton and phytoplankton has been observed in bigheaded carp, although their impact on primary producer biomass is not well understood. Although field observations suggest that condition and abundance of native planktivores, including gizzard shad and bigmouth buffalo (Ictiobus cyprinellus), as well as zooplankton density, have declined following the bigheaded carp invasion, there is little direct, experimental evidence of bigheaded carp food web impacts. Therefore, I sought to examine the effects of bigheaded carp on native ecosystems through a series of mesocosm experiments at the Southern Illinois University pond facility. My primary objectives were to 1) observe potential competition between bigheaded carp and the native gizzard shad, 2) evaluate effects of bigheaded carp predation on zooplankton and phytoplankton communities, 3) assess impacts of bigheaded carp decomposition on nitrogen and phosphorus availability, and 4) measure the rate at which bigheaded carp excrete nitrogen and phosphorus. In order to elucidate the impacts of bigheaded carp on gizzard shad growth and survival, zooplankton and phytoplankton densities, and nitrogen and phosphorus availability in the pelagic and benthic pools and to determine whether gizzard shad experience a diet shift in response to bigheaded carp presence, I performed two mesocosm experiments with three treatments: gizzard shad only, gizzard shad, bigheaded carp, and fishless control (Chapter 1). I predicted that bigheaded carp would reduce zooplankton densities but that gizzard shad, which are both detritivorous and planktivorous, would be unaffected due to their ability to use detritus as an alternative food source. Additionally, both predator release via zooplankton consumption and increased nutrient availability from bigheaded carp excretion would stimulate phytoplankton. I found that gizzard shad survival was reduced by bigheaded carp presence but that surviving gizzard shad did not experience a decline in growth in the bigheaded carp plus gizzard shad treatments. This may have been due to the ability of gizzard shad to consume detritus, as foreguts of sampled gizzard shad in Experiment 2 contained mostly detritus. Moreover, phytoplankton density declined in the presence of silver carp in Experiment 2, suggesting silver carp herbivory. In addition, nitrogen and phosphorus availability in either the pelagic or benthic pools did not appear to be impacted by bigheaded carp presence. After demonstrating experimentally the overall negative impact of bigheaded planktivory on native food webs, I focused my remaining two chapters on the effects of silver carp on nutrient availability. In Chapter 2, I outline a decomposition experiment testing for potential changes in pelagic and benthic nitrogen and phosphorus availability and, in turn, phytoplankton, zooplankton, and macroinvertebrate densities in response to silver carp decomposition. Although silver carp die offs have been reported throughout the Midwest, little is known about the magnitude of those die offs and their consequences for the ecosystem. In this study, silver carp decomposition did not appear to alter nutrient availability or densities of phytoplankton or invertebrates. However, in comparison to northern streams in which salmon spawning and decomposition provide an important nutrient subsidy, the mesocosms used in this study have relatively higher background nutrient concentrations. Thus, silver carp decomposition, at least at the densities studied, may have little importance to in-stream nutrient availability. Lastly, because I am interested in how bigheaded carp, particularly silver carp, alter nutrient dynamics in invaded food webs, it is necessary to calculate silver carp nitrogen and phosphorus excretion rates, as well as body nitrogen and phosphorus content (Chapter 3). Nutrient stoichiometry theory predicts a balance between the relative consumption of nutrients by an organism and the extent to which the organism retains nutrients in its tissues or excretes them. Thus, it is a useful tool in determining how an invasive species may alter nutrient availability via consumption and excretion. In Chapter 3, I describe the body and excretion N:P ratios for silver carp, which exhibit a lower body N:P ratio than excretion N:P, suggesting that these organisms may serve as a sink for phosphorus. Moreover, silver carp body excretion N:P ratios were higher than those reported for gizzard shad, suggesting that, in regions where silver carp may replace gizzard shad or lower gizzard shad population density via competition (Chapter 1), silver carp may alter nutrient cycling processes in aquatic ecosystems by shifting the overall available N:P ratio. Bigheaded carp may pose a significant threat to invaded ecosystems through their potential to compete with native species, reduce plankton densities, and alter nutrient availability. However, although bigheaded carp are expanding in range and approaching the Great Lakes, the full extent of their ecosystem impacts remain uncertain. Through my work on bigheaded carp food web impacts, particularly the influence of silver carp on native species and nutrient cycling processes, I have found that bigheaded carp have the capacity to negatively impact invaded ecosystems overall by reducing zooplankton, phytoplankton, and forage fish densities. Moreover, as bigheaded carp in particular continue to reach high densities as they expand in range, their capacity to alter relative nitrogen and phosphorus availabilities must be monitored to understand the extent of their influence. Due to their ability to disrupt top down and bottom up processes in freshwater ecosystems, bigheaded carp constitute a critical environmental issue in the Great Lakes area and throughout the Midwest and, thus, it is imperative to continue to experimentally assess how bigheaded carp interact with native species to the detriment or benefit of U.S. freshwater communities.

Thesis (Ph. D. in Geophysics)--Joint Program in Marine Geology and Geophysics (Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2013.
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Includes bibliographical references.
In this thesis we present results from inversion of data using dense arrays of collocated seismic and magnetotelluric stations located in the Cascadia subduction zone region of central Washington. In the migrated seismic section, we clearly image the top of the slab and oceanic Moho, as well as a velocity increase corresponding to the eclogitization of the hydrated upper crust. A deeper velocity increase is interpreted as the eclogitization of metastable gabbros, assisted by fluids released from the dehydration of upper mantle chlorite. A low velocity feature interpreted as a fluid/melt phase is present above this transition. The serpentinized wedge and continental Moho are also imaged. The magnetotelluric image further constrains the fluid/melt features, showing a rising conductive feature that forms a column up to a conductor indicative of a magma chamber feeding Mt. Rainier. This feature also explains the disruption of the continental Moho found in the migrated image. Exploration of the assumption of smoothness implicit in the standard MT inversion provides tools that enable us to generate a more accurate MT model. This final MT model clearly demonstrates the link between slab derived fluids/melting and the Mt. Rainier magma chamber.
by R. Shane McGary.
Ph.D.in Geophysics

Les neutrinos cosmiques de haute energie (> 100 GeV) offrent l'opportunite d'ouvrir une nouvelle fenetre sur l'Univers et d'apporter des indications pour resoudre certaines enigmes de la Physique des Particules et de l'Astrophysique. Leur observation necessite la conception d'un nouveau type de detecteur. Nous avons caracterise les performances que l'on peut attendre d'un telescope sous-marin a neutrinos de premiere generation compose d'environ mille photomultiplicateurs, pour la detection de cascades contenues. Le seuil du detecteur se situe vers 200 GeV, le volume effectif atteint 8.10^6 m^3 au-dela de 100 TeV. L'ouverture angulaire vaut 4 pi sr, bien que le volume effectif soit plus faible d'environ 50% a la verticale descendante. La resolution spectrale est entre 10 et 15%, et la precision angulaire environ 2degres (sur l'energie et la direction du neutrino). Le taux de bruit de fond induit par les muons atmospheriques est inferieur a 1.8 fois celui du aux neutrinos atmospheriques. Son evaluation reste limitee par la statistique de simulation. Ces resultats soulignent qu'un telescope sous-marin a neutrinos possede de grandes potentialites de decouverte, non seulement de neutrinos muoniques, mais aussi de neutrinos electroniques, et devrait ouvrir une nouvelle ere de l'astronomie.

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A city is made not only to streets, sidewalks, buildings, bridges and viaducts. The city is also built by layers of sediment from the past that blend with layers of sediments present. The city's it's art, it's sociability is written. The aim of this study is to analyze how Mossor? historiographically the narrative is built by Lu?s da C?mara Cascudo. With this objective, we divide the work into three chapters. At first, we investigate the investment that the prefecture of the Mossor? city at the beginning of the forties, under the administration of Dix-sept Rosado, held for the construction of what would be the city's culture. A culture that was linked to the creation of a library, a museum, a university, the completion of several lectures on the themes of the city, and writing the history of Mossor?. The second chapter discusses the historical conditions of possibility that made Lu?s da C?mara Cascudo of the town historian. In the last chapter, we show how Mossor? was built by Cascudo from the specific analysis of the book Notas e Documentos para a hist?ria de Mossor? (1955). We discuss the conditions for its emergence, examining the interplay of interests that enabled its production
Uma cidade n?o ? feita somente de ruas, cal?adas, pr?dios, pontes e viadutos. A urbe ? constru?da tamb?m pelas camadas de sedimentos do passado que se misturam com as camadas dos sedimentos do presente. A cidade ? arte, ? sociabilidade, ? escrita. O objetivo desse trabalho ? analisar como a cidade de Mossor? ? constru?da historiograficamente pela narrativa de Lu?s da C?mara Cascudo. Com esse objetivo, dividimos o trabalho em tr?s cap?tulos. No primeiro, investigamos os investimentos que a prefeitura de Mossor? no in?cio dos anos quarenta, sob a administra??o de Dix-sept Rosado, realizou para a constru??o do que seria a cultura da cidade. Uma cultura que estaria vinculada ? cria??o de uma biblioteca, um museu, uma universidade, ? realiza??o de v?rias palestras sobre as tem?ticas da cidade, e ? escrita da hist?ria de Mossor?. No segundo cap?tulo, abordamos as condi??es hist?ricas de possibilidade que fizeram de Lu?s da C?mara Cascudo o historiador da cidade. No ?ltimo cap?tulo, mostramos como Mossor? foi constru?da por Cascudo a partir da an?lise espec?fica do livro Notas e documentos para a Hist?ria de Mossor? (1955). Discutimos as condi??es de sua emerg?ncia, analisando o jogo de interesses que possibilitaram a sua produ??o

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência dos Alimentos.
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Os extratos aquoso, alcoólico e etéreo de dois subprodutos gerados pela indústria cafeeira (cascas e pó orgânico) foram avaliados quanto ao conteúdo de compostos fenólicos totais e atividade antioxidante, com o objetivo de observar a influência de cada solvente extrator. Para isto, os resíduos, cedidos pelas Companhias Cooxupé (Guaxupé - MG) e Garcafé (Garça - SP), foram submetidos ao método de Folin-Ciocalteau, que quantifica os fenólicos totais, ao método radicalar ABTS [2,2´- azinobis - (3-etilbenzotiazonelina-6-ácido sulfônico)] e ao sistema de co-oxidação ß-caroteno/ ácido linoléico, que medem a atividade antioxidante de cada extrato, tendo sido o último também utilizado para verificar o sinergismo entre as amostras e o antioxidante sintético BHT (butil hidroxi tolueno). Os resultados indicaram uma alta atividade antioxidante nos extratos aquosos das cascas de café; o pó orgânico apresentou capacidade antioxidante em todos os extratos, e a ordem foi: etéreo > alcoólico > aquoso. Foi observada uma correlação linear entre o conteúdo de fenólicos totais e a atividade antioxidante (R2 = 0,9897). Também foi demonstrado o sinergismo entre o extrato aquoso da casca da Companhia Cooxupé a 200 ppm e o BHT, que mostrou uma inibição da oxidação de 88%. Por ter sido a única amostra a apresentar atividade em todos os extratos, o pó orgânico de café foi submetido a um fracionamento, com o intuito de identificar quais os ácidos fenólicos responsáveis pela atividade antioxidante. Estas frações foram submetidas à análise cromatográfica, além da avaliação da atividade antioxidante e do conteúdo de fenólicos totais. Verificou-se que as frações do pó orgânico têm alto conteúdo de fenólicos, variando de 2.013,26 a 4.620,94 mg GAE (equivalentes em ácido gálico) por 100g de amostra (peso seco). As frações de ácidos fenólicos livres, ésteres solúveis e ésteres insolúveis de ácidos fenólicos foram submetidas à cromatografia gasosa, e a quantificação foi baseada nos tempos de retenção dos padrões de ácidos fenólicos. O ácido salicílico foi predominante em todas as frações, com valores acima de 90%. Apesar disto, estas altas concentrações não parecem ser as responsáveis pela atividade antioxidante total. Os resultados apresentados por estes estudos in vitro indicam a possibilidade da utilização destes subprodutos como substituintes dos antioxidantes sintéticos amplamente empregados pelas indústrias, considerando-se a atual preocupação dos consumidores com os efeitos deletérios destes compostos.

The occurrence of lipid oxidation is considerade as one of the main factors that affect the quality of meat and chicken products. This process leads to sensorial changes, to lost of nutritional value, appearance of toxic compounds and the development of free radicaIs that are associated with a variety of human disordens. As an attempt of management this process, various research were developed as a purpose to isolate bioactive compounds, obtained from plant source, that had effective antioxidant activity. This approach has consumers' preference, and also could help in the prevention of diseases. This research evaluated the effect of extracts obtained from potato peel as antioxidants in chicken meat. It was developed two raw extracts (aqueous and purificated) were prepared and injected in the chicken meat, at 0,5% concentration. The samples were stored under freezing (-18°C), analyzed monthly (TBA and pH), along with samples without extract as a contraI, in the time of eight month. An analyses of pH, thiobarbituric acid rate (TBA), antioxidant activity and phenolics were conducted to determine the antioxidant action of raw extracts. The antioxidant activity was highly significant for two raw extracts, it was finded value between 84 and 94% of the inhibition, in the test of to accelerate oxidation in the fat The purificated extract showed a greater yield in the content of the phenolics. The two extracts were effective to control lipid oxidation in the chicken meat. The sensorial quality of meat was not affected by added of the purificated extract, while, the aqueous, induced a change in the fiavour, wich was not accepted by the sensory paneI.
A ocorrência da oxidação lipídica é considerada como um dos principais fatores que afetam a qualidade da carne e dos produtos cárneos avícolas, conduzindo-os a alterações sensoriais, perda do valor nutricional, formação de constituintes tóxicos e a geração de radicais livres, os quais estão diretamente associados ao surgimento de inúmeras doenças que afetam a saúde humana. Na tentativa de controlar este processo, muitas pesquisas tem sido desenvolvidas, com o propósito do isolamento de fitoquímicos naturais, obtidos de diversos substratos vegetais, que possuam uma efetiva ação como antioxidantes, os quais, além de terem a preferência dos consumidores, também possuem a capacidade de atuarem como auxiliares na prevenção de doenças. Assim, este trabalho avaliou a ação de extratos obtidos da casca da batata inglesa como antioxidantes em cortes de frango. Elaborou-se dois extratos (aquoso e purificado), os quais foram injetados nos cortes de frango, na proporção de 0,5%. Armazenou-se as amostras sob congelamento (-18°C), analizando-as mensalmente (TBA e pH), juntamente com as amostras sem extrato (controle) durante 8 meses. Realizou-se análises de pH, TBA, atividade antioxidante e fenóis para avaliar a ação antioxidante dos extratos. A atividade antioxidante encontrada foi elevada para os dois extratos, encontrando-se valores entre 84 e 94% de inibição no teste da oxidação acelerada em banha. O extrato purificado apresentou um maior rendimento na extração de fenóis. Os dois extratos foram efetivos no controle da oxidação lipídica nos cortes de frango. A qualidade sensorial do produto não foi afetada pela incorporação do extrato purificado, entretanto, no aquoso, houve uma redução nos escores de sabor.

Orientadores: Telma Teixeira Franco, Carlos Ricardo Soccol
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: Avanços na biotecnologia, principalmente na área de tecnologia enzimática e de fragmentações, oferecem oportunidades para a utilização econômica de resíduos agroindustriais. A casca obtida durante o processamento do café por via seca tem sido pouco empregada quando comparada com volume em que é gerada. Este resíduo poderia ser mais utilizado se compostos tóxicos como cafeína e taninos fossem removidos. Fungos filamentosos são capazes de assimilar cafeína e taninos de um meio sintético líquido ou de resíduos de café. Existem poucos trabalhos sobre a detoxificação da casca de café e esta nunca foi relatada com cepas de Rhizopus delemar. A via de degradação da cafeína por este microrganismo e as enzimas envolvidas neste processo também não estão descritas na literatura. O objetivo deste trabaJho foi agregar valor a casca de café por fennentação no estado sólido com R. delemar, investigar a via de degradação da cafeína e caracterizar as enzimas envolvidas neste bioprocesso. As condições de fermentação da casca de café por R. delemar foram otimizadas e os melhores níveis de detoxificação (86% de redução da cafeína e 60% de taninos) foram obtidos em frascos de Erlenmeyer com 75% de umidade inicial, 1O6esporos/g substrato seco, pH 6,5 e 28°C. A cinética do processo fermentativo foi conduzida no biorreator de colunas com as condições otimizadas previamente e indicou que o desenvolvimento do fungo filamentoso e a sua respiração foram relacionados com a degradação de cafeína e de açúcares totais presentes na casca de café. A fase exponencial de crescimento microbiano foi encontrada entre 3 e 5 dias, quando foi detectado máximo consumo de 02 e após a máxima produção das enzimas e degradação da cafeína. Valores máximos de atividade enzimática, 1,8 e 3,3 U/g s.s. para a cafeína e a teofilina demetilase respectivamente, foram obtidos após 2 dias de fermentação em frascos de Erlenmeyer. O extrato enzimático foi estável após estocagem a 2°C e o Km estimado, a temperatura e o pH ótimos foram respectivamente 150J.1M, 30°C e pH 6,5 para a cafeína demetilase e 180J.µM, 30°C e pH 7,4 para a teofilina demetilase. Os resultados mostraram boas perspectivas para a utilização de Rhizopus sp. em processos de detoxificação da casca de café e novas oportunidades poderão surgir para a utilização deste bioproduto e para a aplicação do extrato enzimático obtido neste processo
Abstract: Advances in biotechnology, mainly in the area of enzymes and fermentation technology, offer potential opportunities for economic utilization of agro-industrial residues. The coffee husk obtained during dry processing of coffee has been poorly utilized when compared with the produced volume. Removing the toxics compound as caffeine and tannin, this residue could be more utilized. Filamentous fungi are able to assimilate caffeine and tannins from liquid synthetic media or coffee residue. There are few works about coffee husk detoxification and it was never described with strains of Rhizopus delemar. The caffeine degradation pathway and the enzymes involved in this process have not been described in the literature to. The aim of this work was to improve the nutritive value of coffee husk by solid-state fermentation with R. delemar, to investigate the caffeine degradation pathway and to charactecize enzymes involved in this bioprocess. The conditions of coffee husk fermentation by R. delemar were optimized and the best detoxification levels (86% of caffeine and 60% of tannin reduction) were obtained in Erlenmeyer t1asks with 75% initial moisture, 1O6spores/g dry substrate, at pH 6.5 and 28°C. The kinetic of fermentative process was carried out in packed bed column bioreactor using the conditions previously optimized and showed that the development of filamentous fungi and its respiration was related with caffeine degradation and total sugars presents in coffee husk. The exponential phase of microbial growth was achieved between 3 and 5 days, when was detected maximal 02 consumption and after the maximum production of enzymes and caffeine degradation. The maximum activities, 1.8 and 3.3 U/g d.s. for caffeine and the ophylline demethylase respectively, were achieved at 2 days of fermentation in Erlenrneyer :flasks. The enzymatic extracts were stable after storage at 2°C and the Km estimated, the optimum temperature and pH were respectively 150J.1M, 30°C and pH 6.5 for caffeine demethy1ase and 180J.µM, 30°C and pH 7.4 for theophylline demethy1ase. The results showed good prospects of using Rhizopus sp. for the coffee husk detoxification and would open new opportunities for the utilization of this byproduct and for enzymatic extract application
Doutorado
Desenvolvimento de Processos Químicos
Doutor em Engenharia Química

O presente trabalho considerou o potencial de utilização de subprodutos da agroindústria como casca de coco verde e bagaço de cana-de-açúcar, com o intuito de agregar valor a esses materiais, por meio da fabricação de chapas de partículas multicamadas (3 camadas: 2 camadas externas - CE e uma camada interna - CI), utilizando resina poliuretana bi-componente à base de óleo de mamona (PU-mamona). As chapas produzidas foram avaliadas por ensaios termo-físico-mecânicos: condutividade térmica, densidade aparente, perfil de densidade, absorção de água, inchamento em espessura, flexão estática, flexão dinâmica, tração perpendicular, arranchamento de parafuso, dureza Janka e abrasão, com objetivo de verificar as características do material e indicá-lo para usos específicos; microestrutural: microscopia eletrônica de varredura visando identificar características microestruturais do compósito para interpretar as propriedades físico-mecânicas do produto; durabilidade: envelhecimento natural para expor o material a condições ambientais externas e envelhecimento acelerado para exposição a condições internas. Os resíduos utilizados, o adesivo PU-mamona e os parâmetros de produção adotados mostraram-se adequados para fabricar chapas de partículas multicamadas de baixa (529 kg/m3) e média (692 kg/m3) densidade. O ensaio de condutividade térmica permitiu classificar as chapas em estudo na categoria de materiais isolantes onde os valores estiveram entre 0,14 e 0,17 W/m.K. Os perfis de densidade obtidos permitiram observar a variação da densidade ao longo da espessura das chapas e indicou diferenças entre as chapas homogêneas e multicamadas. As chapas multicamadas apresentaram melhores propriedades físico-mecânicas, em comparação com as chapas de partículas homogêneas e atenderam os requerimentos estabelecidos pelos documentos normativos nacionais e internacionais. Os resultados de envelhecimento natural e acelerado indicaram que as chapas em estudo (homogêneas e multicamadas) são sensíveis às condições de exposição externas (temperatura, umidade e radiação) e às condições extremas de exposição interna (umidade e radiação UVB).
This study considered the potential use of agro-industrial wastes like green coconut shell and sugarcane bagasse in order to add value to those materials, by mean fabrication of multilayer particleboards (3 layers: 2 external layers - EL and internal layer - IL), using castor oil-based polyurethane adhesive. The particleboards were evaluated using physic-mechanics tests: density, density profile, water absorption, thickness swelling, static flexure, dynamic flexural, perpendicular traction, screw pullout, Janka hardness and abrasion with the objective to verify the material characteristics and to indicate specific uses, microstructural: Scanning electron microscopy looking to identify microstructural characteristics of composite to interpret the physic-mechanics properties of product, durability: natural aging to expose the material to external environmental conditions and accelerated aging for exposure to indoor conditions. The residues used, the castor oil-based polyurethane adhesive and the parameters of production adopted; proved to be suitable for making multilayer particleboard of low (529 kg/m3) and medium (692 kg/m3) density. The thermal conductivity test allowed to classify the plates in the category of insulating materials with values between 0,14 e 0,17 W/m.K. The density profiles obtained made possible to observe the change of density along the thickness of the boards and showed differences between the homogeneous and multilayer sheets. The multilayer boards presented better physical and mechanical properties in comparison with the homogeneous particleboards and complied with the standards national and international. The results obtained after the natural and accelerated aging indicated that the plates being studied (homogeneous and multilayer) are sensitive to external exposure conditions (temperature, humidity and radiation) and to the extreme conditions of internal exposure (moisture and UVB radiation).

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
The aim of this study was to evaluate the effect of oat grain in relation to soybean hulls and mixtures thereof, as an energy source, the components are not part and carcass characteristics and meat quality of feedlot steers. We used 36 castrated male cattle, originated from the crossing between Charolais x Nellore, age and average final weight of 356.4 kg and 24 months, respectively. The animals were distributed in treatments, as the energy source in the concentrate fraction of the diet with oat grain, soybean hulls or mixture of oat grain and soybean hulls (1:1). The experimental design was a randomized block design with three treatments and 12 experimental units per treatment, each animal an experimental unit. With respect to fat accumulation renal, inguinal, and ruminal set of total fat, there was a significant effect (P <0.05), and the amount of fat and total renal treatments mixture of animal and soybean hulls top the oat. For the other components are not part of the carcass showed no difference between the different energy sources (P> 0.05). As for the effects of energy sources on the quantitative characteristics of the carcass, only differ with regard to the conformation (P <0.05). Since the housing steers the treatments of soybean hulls and oat were carcasses regular conformation and secondly mixing carcasses showed good conformation. The amount of fat was higher in carcasses of animals fed soybean hulls and mixing with respect to oat (P <0.05), there was an inverse relationship to muscle/fat. Regarding the cooling time of housing in the region Longissimus dorsi muscle during periods of 0, 12 and 24 hours there was no significant difference between the pH and temperature (P> 0.05). The pH of the muscle Recto femoralis, animals fed with a mixture of soybean hulls and oat (1:1) showed a lower pH at the time that the carcasses were placed (0 hour) and withdrawals (24 hours) camera cold (P <0.05). No significant values were checked for color, texture, marbling, thawing loss and cooking, organoleptic characteristics and shear force of beef from steers fed different energy sources (P> 0.05). The soybean hulls as the oat mixture between these and do not alter the main characteristics of the carcass and meat, so with different energy sources can be used in the diet of cattle, which benefit producer and refrigerator.
O objetivo do presente estudo foi avaliar o efeito do grão de aveia branca em relação à casca do grão de soja e suas misturas, como fonte energética, sobre os componentes não integrantes e as características da carcaça e qualidade da carne de novilhos terminados em confinamento. Utilizaram-se 36 bovinos machos castrados, oriundos do cruzamento entre as raças Charolês x Nelore, com idade e peso vivo médios finais de 24 meses e 356,4 kg, respectivamente. Os animais foram distribuídos nos tratamentos, conforme a fonte energética na fração concentrada da dieta, com grão de aveia branca, casca do grão de soja ou mistura do grão de aveia branca e da casca do grão de soja (na proporção 1:1). O delineamento experimental foi o de blocos ao acaso, com três tratamentos e 12 unidades experimentais por tratamento, sendo cada animal uma unidade experimental. Com relação ao acúmulo de gordura renal, inguinal, ruminal e conjunto das gorduras totais, observou-se efeito significativo (P<0,05), sendo a quantidade de gordura renal e total dos animais dos tratamentos mistura e casca do grão de soja superior à aveia branca. Para os demais componentes não integrantes da carcaça não observou-se diferença entre as diferentes fontes energéticas (P>0,05). Quanto aos efeitos das fontes energéticas sobre as características quantitativas da carcaça, apenas apresentaram diferença com relação à conformação (P<0,05). Sendo que a carcaça dos novilhos dos tratamentos casca do grão de soja e aveia branca tiveram carcaças de conformação regular e por outro lado a mistura apresentou carcaças de conformação boa. A quantidade de gordura foi maior nas carcaças dos animais dos tratamentos casca do grão de soja e mistura com relação à aveia branca (P<0,05), observou-se comportamento inverso para relação músculo/gordura. Com relação ao tempo de resfriamento da carcaça na região do músculo Longissimus dorsi, nos períodos de 0, 12 e 24 horas não ocorreu diferenças significativas entre o pH e temperatura (P>0,05). Quanto ao pH do músculo Recto femoralis, os animais alimentados com mistura de casca do grão de soja e aveia branca (1:1) apresentaram menor pH no momento que as carcaças foram colocadas (0 hora) e retiradas (24 horas) da câmera fria (P<0,05). Não foram verificados valores significativos para cor, textura, marmoreio, perdas ao descongelamento e a cocção, características organolépticas e força de cisalhamento da carne de novilhos alimentados com diferentes fontes energéticas (P>0,05). A casca do grão de soja como a aveia branca e a mistura entre essas não alteram as principais características da carcaça e da carne, portanto as fontes energéticas estudadas podem ser utilizadas na dieta de bovinos, as quais beneficiam produtor e frigorífico.

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2011
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O Brasil é atualmente o maior produtor mundial de café, representando 30% do mercado, com um volume equivalente a soma dos outros seis países de maior produção. A grande produção e também o consumo de café levam a geração de uma enorme quantidade de resíduos. Devido à importância dos diferentes compostos presentes nos resíduos de café, a obtenção de extratos a partir dessas fontes seria uma alternativa de agregação de valor de valor a um subproduto agroindustrial tão abundante. Assim, o objetivo deste estudo foi a obtenção de extratos de casca e de borra de café, utilizando tecnologia supercrítica e métodos de extração a baixa pressão, a fim de avaliar o potencial antioxidante e a composição dos extratos, e ainda fazer a determinação dos parâmetros cinéticos do processo de ESC. Os extratos obtidos pelos métodos a baixa pressão (soxhlet e ultrassom) mostraram maiores rendimentos quando comparados à extração supercrítica. O potencial antioxidante foi avaliado pelos métodos DPPH, ABTS e Folin-Ciocalteau, sendo que os melhores potenciais antioxidantes foram verificados para os extratos de casca de café obtidos à baixa pressão. A quantificação e identificação dos extratos foram avaliadas por Cromatografia Líquida de Alta Eficiência (CLAE). Os principais compostos identificados foram cafeína e ácido clorogênico.

Two codes have been developed and implemented for use on massively parallelsuper computers to simulate two-dimensional and quasigeostrophic turbulence.The codes have been found to scale well with increasing resolution and width ofthe simulations. This has allowed for the highest resolution simulations of two-dimensional and quasigeostrophic turbulence so far reported in the literature.The direct numerical simulations have focused on the statistical characteristicsof turbulent cascades of energy and enstrophy, the role of coherent vorticesand departures from universal scaling laws, theoretized more than 40 yearsago. In particular, the investigations have concerned the enstrophy and energycascade in forced and decaying two-dimensional turbulence. Furthermore, theapplicability of Charney’s hypotheses on quasigeostrophic turbulence has beentested. The results have shed light on the flow evolution at very large Reynoldsnumbers. The most important results are the robustness of the enstrophycascade in forced and decaying two-dimensional turbulence, the unexpecteddependency on an infrared Reynolds number in the spectral scaling of theenergy spectrum in the inverse energy cascade, and the validation of Charney’spredictions on the dynamics of quasigeostrophic turbulence. It has also beenshown that the scaling of the energy spectrum in the enstrophy cascade isinsensitive to intermittency in higher order statistics, but that corrections mightapply to the ”universal” Batchelor-Kraichnan constant.

FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
The fertilization of the soil, traditionally made with the use of mineral fertilizers, is one of the biggest costs of agricultural production. In this way, small and medium producers have difficulties in ensuring good soil fertility conditions. The objective of this study as to determine the combination of mineral fertilizer and organic fertilizer that gives the est answer for the growth and production of castor bean. The experiment was carried out between April and September 2014. The statistical design was randomized blocks, which were tested 25 treatments distributed in a factorial 5 x 5, with combined five doses of mineral fertilizer (0, 75, 150, 225 and 300 kg ha-1 of N + P2O5 + K2O in a ratio of 1: 1: 1) and five levels of fertilizer (0, 1.25, 2.50, 3.75 and 5.0 t ha-1 composite castor bean cake). The experiment was conducted in the municipality of CrateÃs, state of CearÃ. The soil of the region is a ultisol Yellow eutrophic, with sandy loam texture. The area was irrigated daily with a sprinkler system located dripline with 4.14 L of 1-time average flow, and the volume of water used was about 300 mm per month. It was evaluated the production weight components, number of fruit and seed weight of the primary raceme, number of racemes per plant, weight of 100 seeds, and yield, as well as the concentrations of macro and micronutrients in leaf of castor bean. The highest yield was achieved in the use of fertilizer combined with 3.75 tons ha-1 of organic fertilizer with 150.0 kg ha-1 of mineral fertilizer. The trend of castor productivity increase was observed for the organic fertilizer with 3.75 tons ha-1 of organic manure combined with mineral fertilizer to the maximum amount of 176.80 kg ha-1 of mineral fertilizer, with maximum production reached approximately 2372.0 kg ha-1. The production component that contributes most to the increase of castor bean productivity is the number of racemes per plant, which can substantially increase the amount of seed for cultivation area.
A adubaÃÃo do solo, tradicionalmente feita com a utilizaÃÃo de adubos minerais, representa um dos maiores custos da produÃÃo agrÃcola. Desta forma, os pequenos e mÃdios produtores tÃm dificuldades para assegurar as boas condiÃÃes de fertilidade do solo. O objetivo deste trabalho foi determinar a combinaÃÃo de adubo mineral e adubo orgÃnico que proporcione a melhor resposta para o crescimento e produÃÃo da mamoneira. O experimento foi realizado entre abril e setembro de 2014. O delineamento experimental adotado foi em blocos ao acaso, onde foram testados 25 tratamentos distribuÃdos em um esquema fatorial 5 x 5, sendo combinadas cinco doses de adubo mineral (0, 75, 150, 225 e 300 kg ha-1 de N+P2O5+K2O na proporÃÃo 1:1:1) e cinco doses de adubo orgÃnico (0, 1,25, 2,50, 3,75 e 5,0 toneladas ha-1 de torta de mamona composta). O experimento foi realizado no municÃpio de CrateÃs, estado do CearÃ. O solo da regiÃo à um ARGISSOLO Amarelo eutrÃfico, com textura franco arenosa. A Ãrea foi irrigada diariamente com sistema de irrigaÃÃo localizada com tubo gotejador de 4,14 L hora-1 de vazÃo mÃdia, sendo que o volume de Ãgua utilizado foi de aproximadamente 300 mm mensais. Foram avaliados os componentes de produÃÃo peso, nÃmero de frutos e peso das sementes do racemo primÃrio, nÃmero de racemos por planta, peso de 100 sementes e produtividade, bem como as concentraÃÃes dos macros e micronutrientes da folha da mamoneira. A maior produtividade foi alcanÃada na utilizaÃÃo de adubaÃÃo combinada com 3,75 toneladas ha-1 de adubo orgÃnico com 150,0 kg ha-1 de adubo mineral. A tendÃncia de aumento de produtividade da mamona foi verificada para a adubaÃÃo orgÃnica com 3,75 toneladas ha-1 de adubo orgÃnico combinada com adubo mineral atà a quantidade mÃxima de 176,80 kg ha-1 de adubo mineral, com a produÃÃo mÃxima alcanÃada de aproximadamente 2372,0 kg ha-1. O componente de produÃÃo que mais contribui para o aumento da produtividade da mamoneira à o nÃmero de racemos por planta, que pode aumentar substancialmente a quantidade de sementes por Ãrea de cultivo.

O presente trabalho propõe o uso das cinzas de dois resíduos agroindustriais - casca de arroz e bagaço de cana-de-açúcar - como fonte de sílica (SiO2) para a síntese de sílicas mesoporosas altamente ordenadas. Esta aplicação, além de agregar valor aos resíduos, busca uma alternativa ao tetraetil ortossicato, uma fonte de sílica dispendiosa, cuja obtenção resulta em danos ambientais. Amostras de cascas arroz de quatro procedências distintas foram caracterizadas por termogravimetria/ termogravimetria derivada (TG/DTG), calorimetria exploratória diferencial (DSC) e análise elementar de CHN. Com base nestes resultados, duas amostras foram selecionadas para obtenção de sílica. Outras duas amostras de bagaço de cana-de-açúcar de origens diferentes foram também caracterizadas por esta metodologia. Para melhor entender as etapas de degradação térmica da matéria orgânica, os resultados de TG/DTG foram associados aos de FT-IR e um estudo cinético por TG foi realizado. Diferentes tratamentos em meio ácido, com o objetivo de remover impurezas e reduzir o tempo necessário para calcinação dos materiais, foram realizados. O método escolhido para cada um dos materiais foi definido a partir dos testes e por avaliação de resultados de TG/DTG. As cinzas obtidas após calcinação em mufla dos materiais com e sem tratamento ácido prévio, foram caracterizadas por MEV/EDS, DRX e isotermas de adsorção/dessorção de N2. As cinzas das amostras com tratamento apresentaram maior pureza que as não tratadas e, para as obtidas a partir casca de arroz, foram amorfas e com alta área superficial BET (200-300 m2.g-1). A síntese de sílicas mesoporosas foi testada empregando-se as cinzas isoladas de amostras tratadas em meio ácido utilizando três rotas sintéticas diferentes. Em uma delas foi possível obter um material de morfologia esférica, com área superficial BET de cerca de 500 m2.g-1 e diâmetro de poro médio (BJH) de 4 nm. A caracterização por espalhamento de raios X a baixo ângulo (SAXS) revelou um ordenamento hexagonal dos poros. Um material de mesma morfologia foi obtido empregando-se silicato de sódio comercial ao invés das cinzas. Os materiais obtidos possuem potencial para diversas aplicações, destacando-se o uso no empacotamento de colunas para cromatografia líquida, encapsulação de fármacos com liberação controlada, catálise e suporte para deposição de materiais.
This work proposes the use of ashes of two agro-industrial wastes - rice husk and sugar cane bagasse - as a source of silica (SiO2) for the synthesis of highly ordered mesoporous silicas. This application, besides adding value to waste, aims an alternative to ortossicato tetraethyl, an expensive source of silica, whose obtaining causes environmental damage. Samples of rice husks from four different sources were characterized by thermogravimetry / derivative thermogravimetry (TG / DTG), differential scanning calorimetry (DSC) and elemental CHN analysis. Based on these results, two samples were selected to obtain silica. Two other samples of sugar cane bagasse from different sources were also characterized by this methodology. To better understand the steps of thermal degradation of organic matter, the results of TG / DTG were associated with FT-IR and a kinetic study was performed by TG. Different treatments in an acid medium were carried out with the aim of removing impurities and reduce the time required for calcination of the materials. The method chosen for each material was defined from the tests and from evaluation of the results of TG / DTG. The ash obtained after the calcination of materials in muffle furnace, with and without prior acid treatment, were characterized by SEM / EDS, XRD and isotherms of adsorption/desorption of N2. The treated samples ashes showed higher purity than those not treated, and for those obtained from rice hulls were amorphous and with high BET surface area (200-300 m2.g-1). The synthesis of mesoporous silicas were tested employing the isolated ash samples treated in acid medium using three different synthetic routes. In one of them it was possible to obtain a spherical morphology material with BET surface area of 500 m2.g-1 and average pore diameter (BJH) of 4 nm. The characterization by small angle X-ray scattering (SAXS) showed a hexagonal ordering of the pores. A material with the same morphology was obtained employing commercial sodium silicate instead of the ash. The synthetized materials have potential for many applications, including packaging of liquid chromatography columns, encapsulation of drugs with controlled release, catalysis and support for deposition of materials.

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Financiadora de Estudos e Projetos
The agro-industrial residues have great potential for providing silicon (Si) and other nutrients for crops. The objective of this work to assess the supply of silicon for organic waste agribusiness, and to evaluate the influence of this nutrient in the accumulation of nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg ) and sulfur (S) in maize. We analyzed the accumulation of silicon in the leaves and stems of the plant and the effect of these sources in stem diameter, the height and mass of dry corn plant, as well as the accumulation of N, P, K, Ca, Mg and S in corn leaves provided by agro-industrial residues and by levels of silicon used. The experiment was conducted in a greenhouse in a completely randomized design (4x3) + 1. We evaluated three sources organic agribusiness (bagasse ash from sugar cane filter cake rotary sugarcane and rice hulls), and for the supply of silicon also evaluated the mineral source (calcium silicate PA); three strengths of SiO2 (175 kg ha-1, 350 kg ha-1 and 700 kg ha-1) and additional treatment (control), which received no SiO2. The sources and doses of SiO2 did not affect the mass of dried corn plants. However, the addition of SiO2 dose provided an increase in the diameter of stem of the maize plant. The rice hulls was more efficient among all treatments in Si supply to the corn crop. The supply of Si favors the absorption and consequent accumulation of potassium and phosphorus from the corn plant. There was no relationship between the supply of Si and Mg and S uptake by corn plant. Finally, there was no relationship between the accumulation of Si and the reduction of leaf N in corn plants.
Os resíduos agroindustriais possuem elevado potencial para fornecimento de silício (Si) e outros nutrientes para as culturas agrícolas. Objetivou-se, com esse trabalho, avaliar o fornecimento de silício por resíduos orgânicos agroindustriais, e avaliar a influência desse nutriente no acúmulo de nitrogênio (N), fósforo (P), potássio (K), cálcio (Ca), magnésio (Mg) e enxofre(S) na planta de milho. Foi analisado o acúmulo de silício nas folhas e nos colmos da planta e o efeito dessas fontes no diâmetro do colmo, na altura e na massa da planta de milho seca, assim como o acúmulo de N, P, K, Ca, Mg e S nas folhas de milho proporcionado pelos resíduos agroindustriais e pelas doses de silício utilizadas. O experimento foi instalado em casa de vegetação no delineamento experimental inteiramente casualizado (4x3) + 1. Foram avaliadas três fontes orgânicas agroindustriais (cinza de bagaço de cana-de-açúcar, torta de filtro rotativo de cana-de-açúcar e casca-de-arroz carbonizada), e para o fornecimento de silício também avaliou-se a fonte mineral (silicato de cálcio P.A.); três dosagens de SiO2(175 Kg ha-1, 350 Kg ha-1 e 700 Kg ha1) e o tratamento adicional (testemunha), o qual não recebeu SiO2. As fontes e doses de SiO2 não influenciaram a massa das plantas secas de milho. Entretanto, o acréscimo das doses de SiO2 proporcionou o aumento no diâmetro de colmo da planta de milho. A casca-de-arroz carbonizada mostrou-se mais eficiente entre todos os tratamentos no fornecimento de Si para a cultura do milho. O fornecimento de Si favoreceu a absorção e consequente acúmulo de P e K pela planta de milho. Não se observou relação entre o fornecimento de Si e a absorção de Mg e S pela planta de milho. Por fim, não houve relação entre o acúmulo de Si e a redução do N foliar nas plantas de milho.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
The aim of this study was to evaluate carcass and meat characteristics of lambs from two genetic groups fed diets with different inclusions of soybean hulls in replacement of forage. Forty uncastrated male lambs were used, 20 from the Texel breed and 20 from Ideal breed, weaned approximately at 60 days and housed in individual pens were randomly divided into four groups according to the level of inclusion of soybean hulls in the diet: 0%, 33.5%, 66.5% and 100% of soybean hulls in replacement of sorghum silage. Lambs were slaughtered when they reached 60% of maturity body weight, 27 kg for Ideal breed animals and 32 kg for the Texel breed animals, being determined qualitative and quantitative carcass and meat. Texel lambs had higher average daily weight gain and carcass yield (P<0,05), being higher when it raises the level of soybean hulls. The genetic group did not affect the variables related to fat deposition as marbling, greasing state and subcutaneous fat thickness. The Texel breed, presented greater morphometric measurements of carcass (P<0,05) when compared with Ideal animals. The racial group did not alter the relative weight of the carcass cuts (P>0,05), however affects the tissue composition. Shoulder was the cut that best predicts the total carcass tissue composition of Texel and Ideal lambs. The genetic group affects the protein content of the meat, being superior to the animals of the Texel. The inclusion level of soybean hulls exerts influence on the moisture content of lamb meat. The race affected the pH, temperature, color, odor and cooking losses from lamb meat (P<0,05). The highest levels of soybean hulls result in changes in the texture profile, in lighter meat, with softer flavor and terderness. The race and the level of soybean hulls not affect the cholesterol content (P<0,05). Among the identified fatty acids, only conjugated linoleic acid had significant difference between the two breeds, being superior to the animals of the Texel breed.
O objetivo deste estudo foi avaliar as características da carcaça e da carne de cordeiros de dois grupos genéticos submetidos a dietas com diferentes inclusões de casca de soja em substituição ao volumoso. Foram utilizados 40 cordeiros machos não castrados, sendo 20 provenientes da raça Texel e 20 da raça Ideal, desmamados aproximadamente aos 60 dias e confinados em baias individuais, distribuídos aleatoriamente em quatro grupos de acordo com o nível de inclusão de casca de soja na dieta: 0%, 33,5%, 66,5% e 100% de casca de soja em substituição a silagem de sorgo. Os cordeiros foram abatidos quando alcançaram 60% do peso vivo a maturidade, ou seja, 27 kg para os animais da raça Ideal e 32 kg de peso vivo para os da raça Texel, sendo determinadas as características qualitativas e quantitativas da carcaça e da carne. Cordeiros da raça Texel apresentaram maior ganho médio diário de peso e rendimentos de carcaças (P<0,05), sendo superior quando se eleva o nível de casca de soja. O grupo genético não afetou as variáveis relacionadas a deposição de gordura como marmoreio, estado de engorduramento e espessura de gordura subcutânea. A raça Texel, apresentou maiores medidas morfométricas da carcaça (P<0,05) quando comparadas com animais Ideal. O grupo racial não alterou o peso relativo dos cortes da carcaça (P>0,05), entretanto afetou a composição tecidual. A paleta é o corte que melhor prediz a composição tecidual total da carcaça de cordeiros Texel e Ideal. O grupo genético afetou o teor de proteína da carne, sendo superior para os animais da raça Texel. O nível de inclusão de casca de soja exerceu influencia no teor de umidade da carne dos cordeiros. A raça afetou os valores de pH, temperatura, cor, odor e perdas ao cozimento da carne dos cordeiros (P<0,05). Os maiores níveis de casca de soja resultaram em mudanças no perfil de textura, em carne mais clara, de sabor mais fraco e com maior maciez. A raça e o nível de casca de soja não afetaram o teor de colesterol (P<0,05). Dentre os ácidos graxos identificados, somente o ácido linoléico conjugado apresentou diferença entre as raças estudadas, sendo superior para os animais da raça Texel.

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The objective of this work was to evaluate the fermentation characteristics of silage of sugarcane mixed with soybean hulls, bacterial inoculant (L. buchneri) and urea, and their combinations. In addition, intake, milk yield and composition of lactating dairy cows were evaluated. In the first experiment, eight different silages were made using the sugarcane cultivar IAC 86-2480 with the additives: Lactobacillus plantarum/Lactobacillus buchneri (strain NCIMB 40788), urea at the level of 0.5% of the original material and soybean hulls at 10 and 20% of the original fresh material. Eight treatments were tested in mini-silos: pure sugarcane (CN); sugarcane with bacterial inoculant (CNIB); sugarcane with 0.5% urea (CNUR); CNUR + IB (CNIBUR); CNUR + 10% soybean hulls (CNUR10%CS); CNUR + 20% soybean hulls (CNUR20%CS); CNIBUR + 10% CS (CNIBUR10% CS) and CNIBUR + 20% CS (CNIBUR20%CS). The experimental design was a completely randomized with 9 opening periods (1, 2, 3, 7, 15, 30, 60, 120 and 180 days post-closing) with three replicates. We evaluated total, gaseous, and effluent losses as well as the percentages of dry matter, crude protein, neutral detergent (NDF) and acid detergent fiber (ADF). There was no significant effect of bacterial innoculant or urea on silage characteristics: neither pH, dry matter content of silage or gaseous and effluent losses. Urea and bacterial inoculant increased the level of lactic acid and reduced ethanol level (P<0.05) of the silages. The addition of 10 or 20% of soy hulls, by the other side, led to an improvement of silage composition and reduced gaseous and effluent losses, but showed no effect on ethanol or lactic acid of the ensiled sugarcane. In the second experiment, we evaluate the performance of lactating cows fed sugarcane silages with and without soybean hulls or bacterial innoculant. Four lactating cows were randomly assigned to a 4x4 Latin Square design. The experimental treatments tested were: sugarcane silage with bacterial inoculant (CNIB), CNIB with 10% soybean hulls (CNIB10%CS) and CNIB with 20% CS (CNIB20%CS), and a control treatment without additive (CN) pure cane silage (CN). The four experimental periods, lasting 21 days, were splitted into 14 days of adaptation and the following seven days for data collection (milk yield and composition and live weight of the animals). Bacterial inoculant affected negatively dry matter, NDF and protein intake, whereas addition of soybean hulls increase intake of DM, NDF, milk yield and weight gain. The higher the level of soy hulls the higher gain in weight. The inclusion of soy hulls led to weight gain whereas CN or CNIB led to weight losses. It is recommended the addition of soy hulls to the sugarcane chopped material to be ensiled at levels from 10 to 20%.
Objetivou-se com este trabalho avaliar o perfil fermentativo de silagem de cana-de-açúcar aditivada com casca de soja, inoculante bacteriano Lactobacillus buchneri e uréia, em diferentes combinações, além de avaliar consumo e desempenho de vacas lactantes (quantidade e composição do leite produzido). Foram confeccionadas oito silagens diferentes, utilizando a cultivar de cana-de-açúcar IAC 86-2480. Como aditivos foram utilizados: inoculante bacteriano foi o Lactobacillus buchneri (cepa NCIMB 40788), uréia na proporção de 0,5% da matéria original e casca de soja nas proporções de 10 e 20% na matéria original. No primeiro experimento, foram utilizados mini-silos, com oito tratamentos: cana pura (CN); CN + inoculante bacteriano (CNIB); CN com 0.5% uréia (CNUR); CNUR + IB (CNIBUR); CNUR + 10% casca de soja (CNUR10%CS); CNUR + 20% de casca de soja (CNUR20%CS); CNIBUR + 10% CS (CNIBUR10% CS) and CNIBUR + 20% CS (CNIBUR20%CS). O delineamento experimental foi inteiramente casualizado, com 9 períodos de abertura dos silos experimentais (1, 2, 3, 7, 15, 30, 60, 120 e 180 dias pós-fechamento) e 3 repetições. Foram avaliadas as perdas totais, gasosas e por efluentes, além das porcentagens de matéria seca, proteína bruta, fibra em detergente neutro e fibra em detergente ácido. Não foram detectados efeitos do inoculante bacteriano ou uréia sobre as características da silagem, como pH, teor de matéria seca e perdas por efluentes ou gases. Uréia e inoculante bacteriano aumentaram o teor de ácido lático e reduziu o teor de etanol das silagens (P<0,05). A adição de casca de soja, por outro lado, melhorou a composição da silagem com redução nas perdas, mas não afetou os teores de etanol ou ácido lático da cana ensilada. No segundo experimento, foram utilizadas quatro vacas para avaliação da produção de leite e sua composição. Essas foram alimentadas com silagem de cana-de-açúcar com e sem casca de soja, em delineamento experimental quadrado latino 4x4. Os tratamentos foram silagem de cana com inoculante bacteriano (CNIB), silagem de cana com inoculante bacteriano e 10% de casca de soja (CNIB+10%CS) e silagem de cana com inoculante bacteriano e 20% de casca de soja (CNIB+20%CS). O tratamento controle foi silagem de cana pura (CN). Os quatro períodos experimentais, com duração de 21 dias, foram divididos em adaptação (14 dias) e coleta de dados de produção e composição do leite, e mudanças no peso vivo. O inoculante bacteriano afetou negativamente o consumo de matéria seca, de FDN e proteína bruta, enquanto a adição de casca de soja aumentou o consumo de matéria seca, de FDN e a produção de leite. A adição de casca de soja proporcionou ganho de peso, com o nível de 20% superando o nível de 10%. Enquanto a inclusão de casca de soja proporcionou ganho de peso, os tratamentos CN e CNIB levaram a perdas de peso. Recomenda-se a adição de casca de soja a massa a ser ensilada de cana-de-açúcar em níveis entre 10 a 20%.

La microspectroscopie Raman cohérente (CARS) est une méthode d'analyse optique sans marqueur qui permet d'identifier des liaisons moléculaires dans un milieu d'intérêt (échantillon) pour permettre de déterminer la composition chimique de ce milieu. Elle nécessite l'excitation concomitante de l'échantillon par deux ondes spectralement décalées (onde pompe et onde Stokes) afin de faire entrer en résonance les liaisons à détecter. Pour la détection de plusieurs liaisons simultanément (microspectroscopie Raman cohérente large-bande ou Multiplex-CARS), la source Stokes monochromatique est remplacée par une source laser large-bande (supercontinuum). Les travaux effectués dans le cadre de cette thèse visent à proposer de nouvelles sources de supercontinuum émettant des faisceaux optimisés en termes d'élargissement spectral et de densité spectrale de puissance pour la microspectroscopie Multiplex-CARS. Pour ce faire, les moyens de développer des continuums spectraux performants ont été explorés dans trois fibres optiques différentes: une fibre microstructurées air/silice monomode à gros cœur dopé à l'ytterbium permettant une réamplification du signal tout au long de sa propagation ; une fibre monomode conventionnelle en régime de dispersion normale pour obtenir un élargissement spectral par saturation du gain Raman ; une fibre multimode dans laquelle le faisceau spectralement élargi par saturation du gain Raman à très forte puissance subit également un auto-nettoyage spatial par effet Kerr tout au long de sa propagation, produisant en sortie un faisceau de forte brillance dont le profil d’intensité est semblable à celui du mode fondamental. Une étude spectrotemporelle complète est présentée pour ces trois sources
Coherent Raman microspectroscopy (CARS) is an optical method used to identify molecular bonds in a sample in order to analyze and determine its complete composition. It requires the simultaneous excitation of the sample by two waves (the pump wave and the Stokes wave) in order to induce resonant vibration of the bond to be detected. For multiple bonds analysis (broadband coherent Raman microspectroscopy our Multiplex-CARS), the monochromatic Stokes wave must be replaced by a broadband beam (supercontinuum). The aim of this thesis was to design supercontinuum sources optimized for Multiplex-CARS application, in particular in terms of spectral bandwidth and spectral power density. Supercontinuum generation was investigated in three different optical fibers: (i) a microstructured single mode fiber with a large Yb doped core in which the input beam was re-amplified all along its propagation; (ii) a conventional singlemode fiber pumped in the normal dispersion regime in which spectral broadening was achieved by means of Raman gain saturation; (iii) a conventional graded-index multimode fiber in which the beam spectrally broadened by Raman gain saturation at very high power also experienced spatial self-cleaning by Kerr effect, resulting in a high brillance output beam with an,intensity profile close to that of the fundamental mode. A complete spectrotemporal study is achieved for each of these three sources

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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
We studied the effect of substitution of 0, 33, 66 and 100% of ground corn (GC) by soybean hulls (SH) in diet’s concentrate portion of 144 Nellore heifers of 24 to 30 months of age and 263.40 + 13.90 kg of body weight in beginning of feedlot and slaughtered at different weights (<340, 340-370, 370-400 and >400 kg). There was no significant interaction between levels of substitution of GC by SH and slaughter weight classes being these effects studied separately. Diets were composed of 90 % concentrate and 10 % corn silage. The experimental period was 112 days, including the period of adaptation. The dry matter intake was not altered by substitution of GC by SH with mean values of 2.51 % of body weight. The substitution level of GC by SH resulted in a linear increase in NDF intake (1.08, 2.03, 2.92 and 3.78 kg/day) and reduced consumption of NDT (5.78, 5 16, 5.03 and 5.12 kg/day) with the addition of 0, 33, 66 and 100 % of GC by SH substitution, respectively. The average daily weight gain decreased linearly (1.24, 1.11, 1.02 and 0.89 kg / day), while feed conversion increased (6.20, 7.08, 7.77 and 8.67 kg DM intake/kg ADG) for the levels of 0, 33, 66 and 100% SH in the diet, respectively. The body condition score was not influenced by levels of substitution of GC by SH presenting mean values of 3.51 points. The body measurements were not affected by treatments, both on the back as the withers, with mean values of 138.5 and 133.25 cm, respectively. Measures of thorax perimeter and body length decreased linearly with the inclusion of SH levels. The slaughter weight decreased linearly with values of 383.52, 374.71, 363.25 and 366.27 kg for levels of 0, 33, 66 and 100 % replacement of GC for SH, respectively, however the hot carcass weight or cold were not affected by the replacement of GC by SH and showed average values of 203.52 and 199.25 kg, respectively. There was no effect of dietary treatment on hot carcass yield showing mean values of 54.92 %. The conformation of the carcasses was not affected by the replacement of GC by SH, with average values of 9.16 points. The subcutaneous fat thickness and loin eye area were not affected by dietary treatments and showed mean values of 5.3 mm and 53.08 cm2, respectively. The yields of primary carcass cut (front, special needle and side cut) were not affected by SH inclusion levels and showed average values of 36.52, 51.72 and 11.55%, respectively. The objective measurements of carcass were not affected by replacement levels of GC by SH. It was found linear effect of treatments on the compactness of carcasses showing average values of 1.56, 1.57, 1.51 and 1.45 cm/kg of cold carcass, to replacing levels of 0, 33, 66 and 100% of SH, respectively. The color and texture of meat were not influenced by dietary treatments and showed average values of 3.30 and 3.19 points, respectively. The marbling of the meat was not influenced by the substitution of GC by SH presenting mean values 8.56 points, with amplitude values between 2 and 17 points. The elevation of slaughter weight resulted in increased weights of hot and cold carcass. Animals slaughtered with weight >400kg had hot carcass yield of 52.76 %, lower than the group of 370-400 kg (56.55 %). The subcutaneous fat thickness was not affected by slaughter weight in any of the expression forms of this variable, with mean values of 5.26 mm and 2.67% of the cold carcass weight. The loin eye area increased with the increase of slaughter weight, and the correlation between these variables was 0.62 (P=0.001), however, when this variable was expressed to 100 kg cold carcass this difference disappeared, with average scores of 26,72 cm2 for each 100 kg of cold carcass. The animals slaughtered with weight >400kg showed better conformation (9.79 points) compared to the other weight classes did not differ among themselves. There was a significant effect of slaughter weight on the carcasses length, arm perimeter and cushion thickness which increased 5.9, 2.3 and 3.12 cm, respectively, amounted to slaughter weight of <340 to >400 kg. Animals slaughtered with weight >400kg had higher carcass compactness compared to the other treatments (1.65 cm long/ kg of cold carcass weight). The absolute weights of primary cuts of the carcass increased with the slaughter weight, however to adjust the weights of the front and rear to 100 kg of cold carcass, this difference disappeared, with values of 36.59 and 51.99%, respectively. The color and texture of the meat were not influenced by slaughter weights showing average values of 3.28 and 3.19 points, respectively. The marbling of the meat was lower in the group of animals slaughtered weighing less than 340 kg compared to the other weight classes did not differ among themselves. It was concluded which although not influence the main carcass characteristics, the replace of ground corn by soybean hulls in high concentrate diets is not efficient because has depressing effect on the productive performance, notably weight gain and feed conversion. Feedlot Nellore heifers must not be slaughtered weighing less than 340 kg because they have lower carcass weight and less marbling of the meat.
Foram estudados os efeitos da substituição de 0, 33, 66 e 100% do milho moído (MM) por casca do grão de soja (CS), na porção concentrada da dieta, de 144 novilhas de descarte da raça Nelore com 24 a 30 meses de idade e 263,40 + 13,90 kg de peso vivo médio inicial, terminadas em confinamento e abatidas com diferentes pesos (<340; 340-370; 370-400 e >400 kg). Não foi constatada interação significativa entre os níveis de substituição do MM pela CS e classes de peso ao abate sendo estes efeitos estudados separadamente. As dietas foram constituídas de 90% de concentrado e 10% de silagem de milho. O período experimental foi de 112 dias, incluindo o período de adaptação. O consumo de matéria seca não foi alterado pelos níveis de CS na dieta com valores médios de 2,51% do peso corporal. A elevação do nível de CS em substituição ao MM resultou em aumento linear do consumo de FDN (1,08; 2,03; 2,92 e 3,78 kg/dia) e redução do consumo de NDT (5,78; 5,16; 5,03 e 5,12 kg/dia) com a inclusão de 0, 33, 66 e 100% de CS em substituição ao MM, respectivamente. O ganho de peso médio diário reduziu linearmente (1,24; 1,11; 1,02 e 0,89 kg/dia), enquanto a conversão alimentar aumentou (6,20; 7,08; 7,77 e 8,67 kg de MS ingerida/kg de GMD) para os níveis de 0, 33, 66 e 100% de CS na dieta, respectivamente. O escore de condição corporal não foi alterado pelos níveis de substituição do MM por CS apresentando valores médios de 3,51 pontos. As medidas corporais de altura não foram influenciadas pelos tratamentos, tanto na garupa quanto na cernelha, apresentando valores médios de 138,5 e 133,25 cm, respectivamente. As medidas de perímetro torácico e comprimento corporal reduziram linearmente, conforme aumentou a inclusão de CS. O peso de abate (PAB) reduziu linearmente apresentando valores de 383,52; 374,71; 363,25 e 366,27 kg para os níveis de 0, 33, 66 e 100% de substituição do MM por CS, respectivamente, entretanto os pesos de carcaça quente (PCQ) ou fria (PCF) não foram alterados pela substituição do MM por CS e apresentaram valores médios de 203,52 e 199,25 kg, respectivamente. Não foi constatado efeito dos tratamentos alimentares sobre o rendimento de carcaça quente que apresentou valores médios de 54,92%. A conformação das carcaças não foi influenciada pela substituição do MM por CS, apresentando valores médios de 9,16 pontos. A espessura de gordura subcutânea (EGS) e a área de olho de lombo (AOL) não foram influenciadas pelos tratamentos alimentares e apresentaram valores médios de 5,3 mm e 53,08 cm2, respectivamente. O rendimento dos cortes primários da carcaça dianteiro, traseiro especial e ponta de agulha não foram alterados pela inclusão de CS e apresentaram valores médios de 36,52; 51,72 e 11,55% da carcaça fria, respectivamente. As medidas objetivas da carcaça não foram influenciadas pelos níveis de substituição do MM por CS. Constatou-se efeito linear decrescente dos tratamentos sobre a compacidade das carcaças apresentando valores médios de 1,56; 1,57; 1,51e 1,45 cm/kg de carcaça fria, para os níveis de 0, 33, 66 e 100% de substituição do MM por CS, respectivamente. A cor e a textura da carne não foram influenciadas pelos tratamentos alimentares e apresentaram valores médios de 3,30 e 3,19 pontos, respectivamente. O marmoreio da carne não foi alterado pela substituição do MM por CS apresentando valores médios 8,56 pontos, com valores de amplitude entre 2 e 17 pontos. A elevação dos pesos de abate resultou em aumento dos pesos da carcaça quente e fria. Animais abatidos com peso superior à 400 kg apresentaram rendimento de carcaça quente de 52,76%, inferior ao grupo de 370-400 kg (56,55%). A EGS não foi influenciada pelos pesos de abate em nenhuma das formas de expressão desta variável, apresentando valores médios de 5,26 mm e 2,67% em relação ao peso da carcaça fria. A AOL aumentou com a elevação dos pesos de abate, sendo a correlação entre estas variáveis de 0,62 (P=0,001) entretanto quando esta variável foi ajustada para 100 kg de carcaça fria esta diferença deixou de existir, apresentando resultados médios de 26,72 cm2 para cada 100 kg de carcaça fria. Os animais abatidos com peso superior a 400 kg apresentaram melhor conformação (9,79 pontos) que os demais grupos experimentais que não diferiram entre si. Verificou-se efeito significativo dos pesos de abate sobre o comprimento das carcaças, perímetro de braço e espessura de coxão que aumentaram 5,9; 2,3 e 3,12 cm, respectivamente, quando elevou-se o peso de abate de <340 à >400 kg. Animais abatidos com peso superior à 400 kg apresentaram maior compacidade das carcaças em relação aos demais tratamentos (1,65 cm de comprimento/kg de carcaça fria). Os pesos absolutos dos cortes primários da carcaça aumentaram conforme elevou-se o peso de abate, entretanto ao ajustar os pesos do dianteiro e do traseiro em relação à 100 kg de carcaça fria, esta diferença deixou de existir, apresentando valores de 36,59 e 51,99%, respectivamente. A cor e textura da carne não foram influenciadas pelos pesos de abate apresentando valores médios de 3,28 e 3,19 pontos, respectivamente. O marmoreio da carne, foi menor no grupo de animais abatidos com peso inferior à 340 kg em comparação ás demais classes de peso que não diferiram entre si. Concluiu-se que apesar de não influenciar as principais características da carcaça, a casca de soja não é eficiente para substituir o milho moído em dietas de alta inclusão de concentrado para novilhas confinadas, pois tem efeito depressivo sobre as principais variáveis de desempenho produtivo, notadamente o ganho em peso e a conversão alimentar. Novilhas de descarte da raça Nelore terminadas em confinamento não devem ser abatidas com peso inferior à 340 kg pois apresentam menor peso de carcaça e menor grau de marmoreio da carne.

The aim of this master’s thesis was to analyze the contemporary electronic throttles and the requirements imposed on them. Then to build the mathematical model, identify parameters of the given electronic throttle, proceed the verification and on its basis to build the simulation model. There were selected suitable control and high power components to control the electronic throttle. Due to the knowledge of these parameters the simulation model was extended. For this extended simulation model was designed the position cascade controller with speed and current control loop. Using the designed controller the implementation of the electronic throttle control and the available high power and control module was realized.

Com o objetivo de avaliar a substituição da FDN do bagaço de cana-de-açúcar in natura (BIN) pela FDN da casca de soja (CS) em dietas com alta proporção de concentrado para cordeiros confinados, foram realizados três experimentos: desempenho animal (Experimento I), digestibilidade dos nutrientes no trato digestivo total (Experimento II) e comportamento ingestivo (Experimento III). O Experimento I consistiu de um arranjo fatorial, onde foram utilizados 60 cordeiros da raça Santa Inês (peso vivo de 16,4 ± 0,3 kg e idade de 67 ± 2 ) dias em um delineamento experimental de blocos casualizados com 5 tratamentos e seis repetições. Os tratamentos utilizados foram: 100C (100% de concentrado), BIN14 (95% de concentrado e 5% de BIN), BIN18 (90% de concentrado e 10% de BIN), CS14 (92% de concentrado e 8% de CS) e CS18 (88% de concentrado e 12% de CS). As dietas foram formuladas para serem isoprotéicas e os teores de BIN e CS ajustados para que os valores de FDN fossem os mesmos entre as dietas BIN14 e CS14 (14%) e entre as dietas BIN18 e CS18 (18%). As dietas contendo CS proporcionaram maior (P=0,07) ganho de peso diário do que as dietas contendo BIN e os cordeiros alimentados com a dieta 100C apresentaram menor (P=0,09) consumo de matéria seca por peso metabóico do que os alimentados com as dietas que continham alguma fonte de fibra (BIN ou CS). Não foi observada diferença (P>0,10) na conversão alimentar. Observou-se uma interação (P<0,07) (Teor x Fonte) para o rendimento de carcaça quente e fria, onde as dietas com 14% FDN apresentaram desempenhos semelhantes, porém, a CS foi superior ao BIN nas dietas contendo 18% FDN. No Experimento II, foram utilizados cinco borregos da raça Santa Inês (35,6 kg PV e com idade de 5,5 meses) em um delineamento em quadrado latino 5 x 5. Os tratamentos utilizados foram os mesmos do Experimento I. As dietas que continham alguma das fontes de fibra promoveram maiores (P<0,05) consumos de matéria seca (MS), matéria orgânica (MO) e da FDN que a dieta 100C. Além disso, foi observado efeito das fontes de fibra sobre o consumo de FDN (P<0,025) e na digestibilidade dos nutrientes (P<0,001), onde a CS promoveu maior digestibilidade da MS, MO e da FDN que o BIN. No Experimento III, foram utilizados os mesmos animais e o mesmo delineamento experimental do Experimento I. As dietas contendo alguma das fontes de fibra promoveram maiores (P<0,05) tempos de ingestão, ruminação e mastigação (minutos/dia e minutos/g de FDN) que a dieta 100C. Ao se comparar as fontes de FDN, verificou-se que o BIN proporcionou maior (P<0,0001) atividade de ruminação que a CS (minutos/dia e minutos/g de FDN). Os teores de FDN interagiram com as fontes nos tempos despendidos para ingestão (P<0,002) e na atividade de mastigação (P<0,03) em minutos/dia e minutos/g de FDN, sendo que o BIN apresentou maiores resultados que a CS em ambos os teores (14 ou 18% FDN). A CS proporcionou melhores ganhos de peso e digestibilidade aparente dos nutrientes do que o BIN, apesar dos resultados indicarem que a FDN da CS possui apenas 14% da efetividade física do BIN. Entretanto, o BIN estimulou a ruminação e mastigação de cordeiros recebendo dietas com alta proporção de concentrado.
Three trials were conduced to evaluate the replacement of sugar cane bagasse (SB) by soybean hulls (SH) as NDF source on lambs fed a high grain feedlot diet. A performance trial (Trial I) with 60 Santa Ines ram lambs (16.4 kg BW and 67 days old), was conduced on a factorial arrangement, in a complete randomized block design, with 5 treatments and six replications. The treatments were: 100C (all concentrate diet), SB14 (95% concentrate and 5% SB), SB18 (90% concentrate and 10% SB), SH14 (92% concentrate and 8% SH) and SH18 (88% concentrate and 12% SH). Diets were isoproteic, and the levels of NDF were adjusted to be 14% (SB14 and SH14) or 18% (SB18 and SH18) for both NDF sources. Animals on SH diets had higher ADG (P=0.07) than animals on SB. 100C diet decreased (P=0.09) dry matter intake (PV 0.75 ) compared to diets containing fiber sources (SB or SH). There was no difference (P>0.10) on feed conversion. An interaction (P<0.07) among NDF source and level was observed for the hot and cold carcasses yields. SH at 18% NDF had higher carcasses yields than SB at the same NDF level. On digestibilty trial (Trial II), five Santa Ines ram lambs (35.6 kg BW and 172 days old), were used in a 5 x 5 Latin square design. Experimental treatments were the same as those used on Trial I. Diets with fiber sources (SH or SB) increased (P<0.05) dry matter (DM), organic matter (OM) and NDF intakes compared to 100C diet. NDF intake (P<0.025) and nutrient digestibilities (P<0.001) were affected by fiber sources, with improved DM, OM and NDF digestibilities for SH treatments compared to SB. During the Trial I a behavioral evaluation (Trial III) was performed. Diets containing fiber sources had an increased (P<0.05) eating, ruminating and chewing times (minutes/day and minutes/g NDF) compared to 100C diet. SB increased (P<0.0001) the rumination activity in relation to SH (minutes/day and minutes/g NDF). There were interactions of NDF levels and sources for time spent feeding (P<0.002) and chewing activities (P<0.03) (minutes/day and minutes/g NDF), where higher for SB in both NDF levels (14 or 18%). SH resulted in higher weight gain and nutrient digestibilities than SB, although, the results indicate that NDF from SH has only 14% of physical effectiveness of SB. However, SB improved rumination and chewing activities when lambs were fed high grain diets.

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A exploração racional de Galinhas da Angola (Numida melagris galeata) pode ser um negócio rentável e sua viabilidade econômica está intimamente ligada ao manejo adequado e capacidade empreendedora do produtor, já que é uma ave extremamente apreciada pelo sabor característico e peculiar de sua carne. Objetivou-se com este estudo avaliar a viabilidade e oportunidade de mercado na criação de Galinhas da Angola como parte do setor avícola. A coleta de dados ocorreu ao longo do ano de 2014 e meados de 2015 em dois municípios do estado do Ceará (Maracanaú e Cascavel), que se destacam no cenário nacional, na exploração comercial e industrial dessas aves. Verificou-se que ao atingirem 100 (cem) dias de idade quando apresentam no mínimo, 1,5kg/ave, são abatidas, atingindo uma média de abates de 3.000 galinhas angolas/mês, da linhagem Francesa, sendo o Kg comercializado (em setembro/2014) pelo valor de RS 16,00. O público consumidor que mais aprecia a carne é a classe média. Toda a produção é escoada na Grande Fortaleza e municípios vizinhos, tendo como público alvo, os restaurantes (70%), frigoríficos (28%) e pessoas que adquirem individualmente as aves já abatidas, direto com os produtores (2%). Observou-se que o pequeno produtor que recebe 160 pintos, no final da produção de cada lote, poderá lucrar até R$ 400,00/ciclo de criação, com valor recebido de R$ 2,50/ave, onde poderá lucrar até R$ 800,00/mês quando são entregues dois lotes sem nenhum custo já que toda a despesa com manejo alimentar e sanitário é custeado pelo produtor distribuidor. A exploração de Galinhas da Angola caracteriza-se por ser uma atividade economicamente viável, devido à rusticidade dos animais, minimizando os custos com manejo sanitário e uso de medicamentos. O sistema semi-intensivo de produção é o mais indicado para a criação comercial, por permitir uma maior qualidade vida às aves, pré- requisito que permite um sabor característico a carne, fugindo assim dos padrões dos frangos e galinhas criadas em total confinamento. A criação de Galinhas da Angola mostra-se viável, devido sua boa aceitação pelo mercado consumidor que busca cada vez mais alimentos alternativos e de qualidade, e por garantir uma diversificação e renda extra aos sistemas de produção dos municípios de Maracanaú e Cascavel.
The rational exploitation of chickens Angola (Numida melagris galeata) can be a profitable business and their economic viability is closely linked to adequate management and entrepreneurial capacity of the producer, as is a bird greatly appreciated by the characteristic and peculiar flavor of their meat. The objective of this study was to evaluate the feasibility and market opportunity in creating chickens Angola as part of the poultry sector. Data collection took place during the year 2014 and mid-2015 in two cities in the state of Ceara (Maracanau and Cascavel), which stand out on the national scene, in the commercial and industrial exploitation of these birds. It was found that on reaching one hundred (100) days of age when they present at least 1.5 kg / bird is slaughtered, reaching an average of 3,000 Angolans slaughter chickens / month, the French lineage, being marketed Kg (in September / 2014) in the amount of RS 16.00. The consumer audience that appreciates more the flesh is the middle class. The entire production is sold in the Fortaleza Grande and neighboring municipalities, with the target audience, restaurants (70%), refrigerators (28%) and people who individually have already slaughtered birds, direct with producers (2%). It was observed that the small producer who receives 160 chicks at the end of each production batch, it may profit to R $ 400.00 / creation cycle with value received from R $ 2.50 / bird where you can earn up to R $ 800.00 / month when they are delivered two lots at no cost since all spending on food and health management is funded by the distributor producer. The exploitation of chickens Angola is characterized for being an economically viable activity, due to the rusticity of animals, minimizing the costs of health management and use of medications. The semi-intensive production system is the most suitable for business creation by enabling a higher quality life to the birds, prerequisite that allows a characteristic meat flavor, thus escaping the standards of chickens and hens in virtual confinement. The creation of chickens Angola proves feasible, due to its good acceptance by the market seeking more and more alternative and quality food, and ensuring diversification and extra income to production systems in the municipalities of Maracanau and Cascavel.

O presente trabalho teve como objetivo estudar a viabilidade da utilização de cinzas de resíduos agroindustriais (bagaço de cana-de-açúcar, cama de frango e casca de arroz) como aditivos minerais substitutos ao cimento Portland, na produção de compósitos fibrosos e concreto leve. As cinzas foram obtidas através da queima e moagem controlada dos resíduos, e tiveram suas características químicas e físicas analisadas. Além do \"compósito referência\" (0% de substituição), os compósitos fibrosos foram produzidos com teores de substituição de cimento Portland de 10%, 15% e 20%, e os concretos leves foram produzidos com 10% de substituição. Foram realizados ensaios físicos e mecânicos nos compósitos fibrosos e concreto leve. Os resultados mostraram que as cinzas de casca de arroz apresentaram propriedades pozolânicas e que podem ser empregadas para a produção dos compósitos fibrosos e concretos leve. No estudo com compósitos fibrosos, os resultados físicos e mecânicos em sua maioria indicaram que a cinza de casca de arroz apresentou os melhores resultados. Como não apresentaram propriedades pozolânicas, as cinzas de bagaço de cana-de-açúcar e cama de frango, mesmo apresentando bons resultados, podem ser utilizadas como \"micro-fillers\". No estudo com concreto leve, a cinza de casca de arroz também se apresentou como melhor substituto para o cimento Portland por apresentar os melhores resultados nos ensaios realizados.
This research examines the viability of the use of waste agro industrials ashes (sugar cane bagasse, poultry litter and rice husk) and mineral additives substitutes to Portland cement in the production of composite fiber and lightweight concrete. The ashes were obtained through controlled burns and milling waste, and had their chemical and physical characteristics analyzed. Besides the \"composite reference\" (0% substitution), the fiber composites were produced with levels of replacement of Portland cement, 10%, 15% and 20%, and lightweight concrete were produced with 10% of replacement. Were tested on physical and mechanical fiber composites and lightweight concrete. The results showed that the ashes of rice husk had pozolanic properties and can be used for the production of fiber composite and lightweight concrete. In the study with fiber composites, the results physical and mechanical mostly indicated that the rice husk ash showed the best results. As there had pozolanics properties, the ashes of sugar cane bagasse and poultry litter, even showing good results, can be used as \"micro-fillers\". In the study with lightweight concrete, the ash of rice husk is also presented as a better replacement for Portland cement by presenting the best results in tests.

Introduction: Au Nigeria, la couverture de la détection et du traitement de la tuberculose pharmaco-résistante (TPR) est toujours faible malgré la mise en place de services gratuits depuis 2011. Le pays se classe au sixième rang mondial avec une proportion de cas de patients résistants aux médicaments de 4,3% et de 15% dans les cas d’une réinitialisation au traitement. Le pays a aussi un fardeau élevé pour la tuberculose, la TPR, et le VIH, avec une prévalence de 219 et 11 pour 100 000 habitants pour la tuberculose et la TPR et de 1,28 pour 1 000 habitants pour le VIH. Sans traitement, la mortalité due à la tuberculose est d'environ 70% en dix ans, augmentant avec la coïnfection par le VIH, et la résistance aux médicaments; et descendant en dessous de 5% avec traitement. Les taux de survie de la tuberculose pharmaco-résistante sont plus faibles et le traitement est plus long, plus coûteux et plus toxique. Cela peut poser des défis différents à la fois pour les patients et les systèmes de santé comparativement à la tuberculose de la forme commune. Cependant, la réponse au traitement et la survie sont influencées par la détection précoce et à l'initiation rapide au traitement, idéalement dans les quatre semaines suivant le diagnostic, en particulier avec la coïnfection par le VIH. Les caractéristiques sociodémographiques interagissent souvent de manière complexe avec des facteurs systémiques, pour accroître la vulnérabilité et les désavantages - ces interactions sont particulièrement bien examinées à travers un cadre conceptuel d'équité à l'accès à la santé, et pourrait offrir des analyses et des recommandations pertinentes pour les politiques. Cette thèse explore les barrières et les facilitateurs à l’accès au diagnostic et au traitement au niveau des patients et du système de santé au Nigéria. Méthodes: Cette thèse est une étude transformative de méthodes mixtes. Nous avons d’abord réalisé une revue systématique mixte pour identifier les obstacles et les facilitateurs influençant l’accès au diagnostic et au traitement de la TPR en Afrique subsaharienne. Nous avons par la suite mené une méta-synthèse qualitative pour examiner en profondeur les obstacles aux soins de la tuberculose auxquels se heurtent les patients, la communauté, et le système de santé. Nous avons utilisé les résultats des deux revues systématiques pour affiner notre cadre conceptuel afin d'orienter la conception et l'analyse de l'étude empirique qui a suivi. Le cadre conceptuel adapté est basé sur le cadre de Levesque. Ce cadre centré sur les patients conceptualise l’accès aux soins selon des dimensions du système de santé et des patients. Cette étude comprenait également une analyse rétrospective d’une cohorte de patients diagnostiqués en 2015 (n = 996) à l'aide de données secondaires nationales et une analyse en cascade des soins de la tuberculose pharmaco-résistante entre 2013 et 2017. Nous avons mené des analyses statistiques descriptives et analytiques. Nous avons effectué une régression logistique et d'autres tests d’association pour mesurer la relation entre les variables catégorielles. L’étude qualitative était une étude de cas qui consistait à examiner la dynamique de soins du point de vue des patients (n = 86 participants, n = 7 groupes de discussions, 5 entretiens approfondis avec des patients diagnostiqués et non traités), leurs familles (n = 19 participants, n = 1 groupe de discussion, 7entretiens approfondis ), membres de la communauté (n = 23 , n=2 groupes de discussion), agents de santé (n = 5 entretiens approfondis) et gestionnaires de programme (n = 29 entretiens approfondis) dans quatre États du Nigéria. Nous avons analysé nos données qualitatives à l'aide d'une analyse thématique. Résultats: Notre revue systématique mixte et notre méta-synthèse qualitative ont indiqué des obstacles et des facilitateurs à l’accès aux soins de la tuberculose pharmaco-résistante au niveau du système de santé et des patients. Les problèmes de fonctionnement des laboratoires et des cliniques, l’absence de connaissances et les attitudes des prestataires de soins, et la gestion de l'information étaient des obstacles à l’accès aux soins de la TPR. Les facteurs facilitateurs comprenaient des outils de diagnostic plus récents, la décentralisation des services et le coût gratuit des soins. Au niveau des patients, la perte de suivi avant ou pendant les soins en raison de la perception négative des soins dans les services publics, le genre, la famille, l’engagement professionnel ou scolaire, et le recours aux soins dans le secteur privé constituaient des obstacles. Les facilitateurs étaient la séropositivité pour VIH, la multitude de symptômes, et le soutien financier des patients. Nos résultats quantitatifs ont révélé une certaine amélioration mais des progrès insuffisants dans le diagnostic et la couverture du traitement au Nigeria entre 2013 et 2017. Notre analyse en cascade a montré des abandons significatifs entre chaque étape des soins, en commençant par les tests et en terminant par l'achèvement du traitement. En moyenne, 80% des cas estimés n'ont pas eu accès au test; 75% de ceux qui ont été testé n'ont pas été diagnostiqués; 36% des personnes diagnostiquées n'ont pas commencé le traitement et 23% d'entre elles n'ont pas terminé le traitement pour la période entre 2013-2017. En 2015, les patients et les enfants atteints de la TB qui résident au nord du Nigéria avaient une probabilité de 0,3 [IC à 95% 0,1-0,7] et 0,4[0,3-0,5] de terminer le traitement une fois la maladie diagnostiquée comparativement aux patients et aux enfants qui résident au sud du pays. Les hommes avaient une probabilité de 1,34 [IC à 95% 1,0-1,7] plus élevée de terminer le traitement après le diagnostic comparativement aux femmes. La localisation géographique et les niveaux de soins étaient associés à un traitement et / ou à un traitement rapide. Notre étude qualitative a identifié des obstacles aux soins aux niveaux individuel, familial, communautaire, et du système de santé. Certains groupes sociodémographiques de patients avaient un accès inéquitable aux soins de la TPR. Alors que les patients étaient pour la plupart traités de manière égale au niveau de l'établissement, certains patients avaient plus de difficulté à accéder aux soins en fonction de leur sexe, de leur âge, de leur profession, de leur niveau d'éducation, et de leur religion. La dynamique familiale et conjugale influencent l’accès aux soins des patients, en particulier des enfants et des femmes. Elle agissait parfois comme un obstacle aux soins. D’autres facteurs qui ont probablement entravé l’accès incluaient l’absence de considérations sur les droits d’accès et la protection des patients dans les directives de traitement et les protocoles de soins. Les patients ignoraient pour la plupart les causes de la tuberculose pharmaco-résistante et la disponibilité des soins gratuits. Le nombre d'agents de santé et les problèmes de formation, la faible performance des laboratoires et des cliniques sont des obstacles aux soins de la tuberculose au niveau du système de santé. Les principaux facilitateurs à l’accès aux soins comprenaient le soutien familial, le soutien financier aux patients et le traitement gratuit. Conclusions: Malgré la gratuité des tests et des traitements de la TB pharmaco-résistante au Nigéria depuis 2011, les couvertures de diagnostic et de traitement restent constamment faibles. Les obstacles à l’accès au diagnostic et au traitement de la TB et de la TB pharmaco-résistante sont similaires. Toutefois, la TB pharmaco-résistante présente des défis particuliers en raison de la complexité des procédures de prétraitement et des toxicités résultant des médicaments eux-mêmes. Notre étude avait pour objectif de mieux comprendre les facteurs qui influencent l’accès à l'initiation au traitement de la TB pharmaco-résistante. Nos résultats montrent que les obstacles les plus importants sont l'accès aux tests et au diagnostic, malgré les progrès technologiques de diagnostic et des protocoles cliniques. Notre étude a identifié plusieurs obstacles liés aux patients et au système de santé. La plupart des patients atteints de TB pharmaco-résistante n'ont pas accès aux tests et ne sont pas diagnostiqués, souvent en raison d'un manque d'information. Les politiques et les programmes de lutte contre la tuberculose pharmaco-résistante ne sont pas toujours équitables, en particulier pour les populations vivant dans les zones rurales, les enfants, et les femmes. Les résultats de notre étude ont généré des données probantes pertinentes pour les décideurs et les partenaires internationaux pour remédier aux disparités systémiques et fournir des services plus équitables. L'élimination des obstacles à l’accès aux soins en temps opportun devrait être une priorité urgente pour améliorer le programme de lutte contre la tuberculose au Nigéria. Dans la faible détection des cas et la couverture thérapeutique, les interventions devraient viser l'équité en facilitant l’accès aux soins des populations vulnérables.
Background: Detection and treatment coverage for drug-resistant tuberculosis (DR-TB) in Nigeria are persistently low despite the implementation of free diagnostic and treatment services since 2011. Nigeria has a high burden for tuberculosis, ranking 6th globally with 4.3% drug resistance in new, and 15% in retreatment cases. The World Health Organization classifies the country as a high burden for TB, DR-TB, and HIV, with a prevalence of 219 and 11 per 100,000 population for TB and DR-TB, and 1.28 per 1,000 population HIV. Without treatment, mortality from tuberculosis is approximately 70% within ten years, increasing with HIV co-infection and drug resistance - and decreasing to below 5% with treatment. DR-TB survival rates are lower, and treatment is longer, costlier, and more toxic; this may pose different challenges to both patients and health systems than is the case for drug-sensitive (DS-) TB. However, treatment response and survival are positively impacted by early detection and treatment initiation, ideally within four weeks of diagnosis, especially with HIV co-infection. Socio-demographic characteristics often interact in complex ways with systemic factors, to increase vulnerability and disadvantage – these interactions are particularly well examined through an equity of health access framework and could offer policy-relevant analyses and recommendations. This study explores patient and health system barriers and facilitators to diagnosis and treatment for DR-TB in Nigeria. Methods: This is a sequential transformative mixed-methods study. First, a mixed-methods systematic review identified barriers and facilitators affecting diagnosis and treatment for DR-TB in sub-Saharan Africa. A subsequent qualitative meta-synthesis was used to examine in more depth the patient, community, and health system barriers to TB care. The results of the systematic reviews were used to refine our conceptual framework and to guide the design and the analysis of the subsequent empirical study. The adapted conceptual framework is based on the Levesque framework for patient-centred healthcare access, which conceptualises access to care as having health system and patient dimensions. This study also included a retrospective cohort analysis of patients diagnosed in 2015 (n= 996 ) using National secondary data, and a DR-TB care cascade analysis of the period between 2013 and 2017. We used descriptive statistics, logistic regression and other tests of association to measure the relationship between variables categorical. The qualitative phase used a case study design to examine the dynamics of care from patients' perspectives (n= 86 participants, N= 7 focus group discussions (FGD), 5 in-depth interviews (IDIs) with diagnosed and untreated patients), their relatives (n= 19 participants, N= 1 FGD, 7 IDIs ), community members (n=23 in 2 FGDs), healthcare workers (n= 5 IDIs ), and program managers (n= 29 IDIs) in four States in Nigeria. We analysed our qualitative data using thematic analysis. Results: Our mixed methods systematic review and qualitative meta-synthesis revealed barriers and facilitators to DR-TB care at the health system and patient levels. Health system laboratory and clinic operational issues, poor provider knowledge and attitudes and information management were some barriers. Facilitators included newer diagnostic tools, decentralisation of services and free cost of care. At the patient level, loss to follow-up before or during care due to negative public sector care perceptions, gender, family, work or school commitments and using private sector care were some barriers. Facilitators were HIV positivity, having more symptoms, and financial support. Our quantitative findings revealed some improvement but inadequate progress in diagnosis and treatment coverage in Nigeria between 2013 and 2017. Our cascade analysis showed significant dropouts between each stage of care, starting with testing and ending with treatment completion. On average, between 2013-2017, 80% of estimated cases did not access testing; 75% of those who test were not diagnosed; 36% of those diagnosed were not initiated on treatment and 23% of these did not finish treatment. In 2015, children and patients in Northern Nigeria had odds of 0.3 [95% CI 0.1-0.7] and 0.4 [0.3-0.5] of completing treatment once diagnosed; compared with adults and patients in Southern Nigeria; while males were shown to have a 1.34 [95% CI 1.0-1.7] times greater chance of completing treatment after diagnosis compared to females.. Geographic locations and levels of care were associated with ever receiving treatment and or timely treatment. Our qualitative data and document review identified barriers to care at individual, family, community, and health systems levels. Some patient socio-demographic groups had inequitable access. While patients were mostly treated equally at the facility level, some patients experienced more difficulty accessing care based on their gender, age, occupation, educational level and religion. Parental and spousal influences affected patients, particularly children, and women, and were sometimes barriers to care. Other factors that likely hampered access include the absence of considerations for patients’ access rights and protection in the treatment guidelines and workers manuals. Patients were mostly unaware of the causes of DR-TB disease and the availability of free care. Health worker numbers and training, clinic, and operational laboratory issues limited patients’ access at the health system level. The main facilitators to care included family support, patient financial support, and free treatment. Conclusions: Despite the provision of free DR-TB testing and treatment in Nigeria since 2011, coverage for diagnosis and treatment remain persistently low. Our literature review identified many of the same access factors affecting both DS-TB and DR-TB. However, DR-TB had peculiar challenges due to complexities in pre- treatment procedures, and in toxicities as a result of the medications themselves. This study was designed to investigate the access factors impacting DR-TB treatment initiation identified in literature. However, our findings showed that the biggest barriers to DR-TB care were essentially in access to testing and diagnosis, making any advances in diagnostic technology and treatment regimens of little benefit to DR-TB patients in Nigeria. Several patient and health system factors were shown to impede access to DR-TB care, particularly for certain groups of patients. Most DR-TB patients are not accessing testing and do not get diagnosed, often due to a lack of information. Also, DR-TB policies, structures and processes are not always equitable, especially for rural dwellers, children and women. Findings from our mixed methods study provided the additional insights needed by policymakers and implementing partners to address systemic disparities and provide more equitable services based on the population's needs. Eliminating barriers that negatively impact timely access to care should be an urgent priority for the TB program in Nigeria. In Nigeria's low case-finding and treatment coverage, interventions should target equity and ease of access, specifically for the barriers identified at the patient and health system levels.

RESUMO - Introdução: A infeção por VIH continua a ter uma prevalência e incidência elevadas em todo o mundo. Para se conseguirem melhores resultados em saúde e garantir a supressão virológica, é essencial que as pessoas infetadas mantenham uma vigilância periódica e permanente nos cuidados de saúde, desde o momento do seu diagnóstico. Objetivos: Identificar os fatores que condicionam positiva e negativamente a retenção nos cuidados de saúde das pessoas com infeção por VIH. Metodologia: Realizou-se uma revisão sistemática da literatura com resultados nas bases de dados B-On, PubMed, ScienceDirect e Google Académico. Selecionaram-se os artigos publicados entre 2011 e 2016, com metodologia observacional, realizados em países desenvolvidos e que analisaram os fatores que condicionam a retenção nos cuidados de saúde das pessoas adultas com infeção diagnosticada por VIH. Resultados: Doze artigos cumpriram os critérios de inclusão, todos estudos de coorte. De acordo com os resultados estatisticamente significativos dos estudos analisados, identificaram-se como fatores mais associados à retenção nos cuidados de saúde o sexo masculino, as idades mais velhas, a etnia caucasiana, os homens que têm sexo com homens ou o tratamento com TARc. A não retenção nos cuidados de saúde apresentou maior associação com o sexo feminino, idades mais jovens, etnia negra e categorias de transmissão heterossexual ou pela injeção intravenosa de drogas. Discussão/Conclusões: Existe alguma consistência na evidência científica de que determinadas características demográficas, sociais e clínicas influenciem a retenção nos cuidados de saúde, permitindo-se assim determinar grupos de risco e diferenciar a prestação de cuidados de saúde para prevenir perdas de acompanhamento.
ABSTRACT - Introduction: HIV infection continues to have high prevalence and incidence worldwide. In order to achieve better health outcomes and to ensure viral suppression, it is essential to maintain periodic and permanent health surveillance of infected persons, since their diagnosis. Objectives: To identify which factors affect positively and negatively retention in care for HIV infected people. Methods: A systematic review was conducted obtaining results in the B-On, PubMed, ScienceDirect and Google Scholar databases. The selected articles were published between 2011 and 2016, had observational methodology, were conducted in developed countries and analyzed the factors conditioning retention in care in the diagnosed HIV infected adult population. Results: Twelve articles met the inclusion criteria, all cohort studies. According to the statistically significant results of the studies analyzed, the factors generally associated with retention in care were male sex, older ages, white ethnicity, men who have sex with men or treatment with cART. Non-retention in health care showed primarily an association with female sex, younger ages, black ethnicity and heterosexual or intravenous injection of drugs as transmission risk factors. Discussion/Conclusions: There is some consistency in the scientific evidence that certain demographic, social, and clinical characteristics influence retention in health care, thus allowing to identify risk groups and to differentiate care delivery to prevent losses to follow-up.

Esta investigação analisa os cuidados domiciliários em instituições de solidariedade a partir de um conjunto de desenvolvimentos recentes: o aumento do número das pessoas idosas dependentes e a acção política na velhice. Situa os cuidados domiciliários como domínio emergente da política, que articula a área social e a saúde, as entidades públicas e privadas, lucrativas e não lucrativas, o trabalho formal e o informal, as pessoas idosas dependentes e os familiares cuidadores. Procurámos compreender em que medida esta política se configura tendo em conta três vertentes: as pessoas idosas dependentes; as instituições de solidariedade com serviços de apoio domiciliário; e a intervenção dos profissionais de Serviço Social coordenadores desses serviços. Analisámos as disposições e as práticas em quatro instituições com estatuto jurídico de IPSS situadas no concelho de Cascais. Estas apresentam estruturas organizativas e funcionais distintas e orientam a acção estratégica, nomeadamente, a capacidade negocial com o estado, a de criar novos recursos e a de promover a participação dos clientes, de acordo com a sua maior ou menor complexidade. Os serviços e os cuidados domiciliários dessas instituições situam-se entre a manutenção/sustentação, o alargamento relativo e substantivo e a diversidade/inovação. O processo de intervenção do Serviço Social orienta-se para a satisfação das necessidades dos clientes de acordo com os recursos disponíveis. Apesar desta tendência, identificamos numa instituição com maior complexidade processos de intervenção inovadores, cuja orientação é a de criar recursos de acordo com as necessidades identificadas. São estas instituições que estão melhor posicionadas para promover a autonomia e a qualidade na velhice.
This research intends to analyse domiciliary care in institutions of solidarity from a set of recent developments: the increase not only of elderly dependents but also of the political actions towards them. It emphasizes home care as an emerging issue of politics, which articulates the social and health areas, public entities and private profit and nonprofit, formal and informal work, the dependent elderly and family caregivers. It aims to understand the extent to which this policy is set taking into account three aspects: the elderly dependent; institutions of solidarity with home care services and the intervention of social work practicioners as coordinators of those services. This study analysed the provision and practice in four institutions with the legal status of IPSS located in the municipality of Cascais. These IPSSs have organizational structures and different operating methods and strategic action guides, including the ability to negotiate with the state to create new resources and to promote the participation of customers, according to organizational degree of complexity. Services and home care of these institutions are among the maintenance / support, and the extension on substantive and diversity / innovation. The process of social work intervention is gerared to meet the needs of customers within the resouces available, through a service led perspective. Despite this trend, we were able to identify an institution more complex, innovative intervention processes in which the tendency is to create resources in accordance with identified needs (needs led perspective). These institutions are far more positioned to promote independence and quality in the elderly.