Дисертації з теми "Cardiovascular system Diseases Victoria Risk factors"
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Heydon, Emma Elizabeth. "Telomere length and cardiovascular disease risk factors in South Asians." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708496.
Повний текст джерелаKhan, Hassan. "Markers of glycaemia and risk of cardiovascular disease." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648585.
Повний текст джерелаAppannah, Geeta. "Dietary patterns, obesity and cardiovascular risk factors in young people." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648138.
Повний текст джерелаBlack, James Alexander. "Optimising cardiovascular risk management early in the diabetes disease trajectory." Thesis, University of Cambridge, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709489.
Повний текст джерелаNg, Kuen-to, and 伍權韜. "The gender difference and association between social position and cardiovascular risk factors in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45012775.
Повний текст джерелаMoore, Vivienne M. "Fetal growth and cardiovascular risk factors in an Australian cohort /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phm824.pdf.
Повний текст джерелаAwotedu, Kofoworola Olajire. "Functional changes of the vasculature leading to some cardiovascular risk factors in HIV/AIDS patients." Thesis, Walter Sisulu University, 2013. http://hdl.handle.net/11260/d1015712.
Повний текст джерелаKavikondala, Sushma. "Intergenerational and life course influences on cardiovascular risk factors from a developing country perspective, and implications foraetiology." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4633211X.
Повний текст джерелаPennells, Lisa. "Assessing predictive ability using individual participant time to event data from multiple prospective studies : application to cardiovascular disease risk prediction." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609800.
Повний текст джерелаXu, Lin, and 徐琳. "Subclinical atherosclerosis, cardiovascular risk factors and metabolicsyndrome in older Chinese people." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4451430X.
Повний текст джерелаZilkens, Renate Ruth. "The effect of alcohol and beverage type on cardiovascular disease risk factors." University of Western Australia. School of Medicine and Pharmacology, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0053.
Повний текст джерелаCheung, Yiu-fai, and 張耀輝. "An analysis of the determinants of peripheral conduit arterial stiffness in children and teenagers in health and disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29761815.
Повний текст джерелаJohns, David James. "Dietary patterns and cardiovascular disease in severe obesity." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610554.
Повний текст джерелаKettle, Susan M. "Prevalence of cardiovascular disease risk factors in young Newfoundland and Labrador adults living in rural and urban communities." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0017/MQ54927.pdf.
Повний текст джерелаHenning, Andrea L. "Monitoring Monocyte Oxldl Phagocytosis As a Cardiovascular Disease Risk Factor Following a High-fat Meal." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc700101/.
Повний текст джерелаMashinya, Felistats. "Cardiovascular risk factors in an HIV infected rural population of Limpopo Province, South Africa." Thesis, University of Limpopo, 2016. http://hdl.handle.net/10386/1717.
Повний текст джерелаRefer to document
The Belgium Development Co-operation through VLIR-UOS, The University of Limpopo,and The Flemish Universities
Masoud, Mohamed Abdulsalam. "Validation of a recently proposed equation for the estimation of small, dense LDL particles from routine lipid measures in a population of mixed ancestry South Africans." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2490.
Повний текст джерелаCardiovascular diseases (CVD) are the leading cause of global mortality, of which over 75% occurred in low- and middle-income countries such as South Africa. The lipid profile, specifically decreased levels of high density lipoprotein cholesterol (HDL-C), elevated triglyceride levels and the presence of small-dense low density lipoprotein (sdLDL) has been reported associated with CVD. An increased number of sdLDL is also common in metabolic syndrome (MetS), visceral obesity and diabetes mellitus, the last a known risk factor for CVD. The modification of low density lipoprotein (LDL) size, or number of sdLDL particles, has been reported to significantly reduce CVD risk, but not conclusively so and needs further investigation. In this regard, sdLDL particles are seldom estimated routinely for clinical use because of financial and other limitations. Currently, an alternative approach for estimating sdLDL is to use equations derived from routine lipid measures, as has been proposed by several groups. However, there is a need for extensive evaluation of this equation across different ethnic and disease groups, especially since reports showed an inadequate performance of the equation in a Korean population. The aim of this study was to assess the performance of a recently proposed equation for the estimation of sdLDL in healthy and diabetic mixed ancestry South Africans. Furthermore, we also investigated the role of sdLDL as a cardiometabolic risk factor, as measured against known risk factors such as the glycemic and lipid profiles.
林文健 and Man-kin Lam. "A cross-sectional study of leisure-time physical activity prevalence and its association with cardiovascular biochemical risk factors inHong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970631.
Повний текст джерелаMartin, Luci A. "Negative affect, introversion and physiological markers of cardiovascular disease." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9063/.
Повний текст джерелаLink-Malcolm, Jessica. "Health message framing : motivating cardiovascular risk factor screening in young adults." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9066/.
Повний текст джерелаSmith, Jessica 1980. "Elevated waist to hip ratio and cardiovascular disease risk, assessed by the apoBapoA1 ratio, in Asian Indian immigrants." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98800.
Повний текст джерелаMaloney, Kelly Veronica. "Awareness, reported behaviour, and dietary intake of fat and fiber as risk factors for cardiovascular disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ54935.pdf.
Повний текст джерелаVu, Manh Tuan. "Feasibility, acceptability and utilization of a moblie cardiovascular risk factor profile e-platform amongst physicians and patients in HongKong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47869823.
Повний текст джерелаpublished_or_final_version
Community Medicine
Master
Master of Philosophy
黃佩儀 and Pui-yi Wong. "The relationships among habitual physical activity, daily eating habits, aerobic fitness and cardiovascular risk factors in Hong Kongmales." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3125732X.
Повний текст джерелаZhou, Haiyun, and 周海韵. "Risk factors driving ambulatory care sensitive conditions hospitalisation among elderly with chronic obstructive pulmonarydisease or heart disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47055819.
Повний текст джерелаKuinchtner, Gabriela Castro. "ASSOCIAÇÃO ENTRE RISCO CARDIOVASCULAR E CONTROLE AUTONÔMICO CARDÍACO EM PORTADORES DE HIV." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/5855.
Повний текст джерелаIntrodução: o aumento do risco de doença cardiovascular tem sido demonstrado em sujeitos com infecção por HIV. A disfunção na regulação do sistema autônomo tem sido apontada como mecanismo subjacente a morte cardíaca nesse grupo de pacientes. Este estudo objetivou analisar a associação entre risco cardiovascular e controle autonômico cardíaco em portadores de HIV. Métodos: a amostra foi composta por 25 pacientes com HIV, de ambos os sexos, em uso de antirretrovirais e com carga viral não detectável, oriundos do Ambulatório de Doenças Infecciosas do Hospital Universitário de Santa Maria (HUSM), entre agosto e dezembro de 2014. Pacientes com doença cardiovascular, metabólica, respiratória, neurológica ou renal foram excluídos. O risco cardiovascular foi avaliado pelo Escore de Framingham, utilizado para estimar a probabilidade de eventos cardiovasculares em dez anos. O controle autonômico cardíaco foi avaliado pela medida da variabilidade da frequência cardíaca, analisando-se as seguintes variáveis: 1) no domínio do tempo foram mensurados o SDNN, índice triangular (variabilidade global) e rMSSD (atividade parassimpática); 2) o domínio da frequência compreendeu os componentes de baixa frequência (LF; atividade simpática) e de alta frequência (HF; atividade parassimpática), ambos normalizados, e a relação LF/HF (balanço simpato-vagal). Resultados: a amostra (12 mulheres e 13 homens) apresentavam idade média de 48,7±10,9 anos, índice de massa corporal de 25,7±5,1 kg/m2, frequência cardíaca de 72,1±13,4 bpm, frequência respiratória de 16,3±3,8 rpm, pressão arterial sistólica de 125,2±18,7 mmHg e diastólica de 83,3±12,2 mmHg. O tempo médio de diagnóstico da doença foi de 10,2±5,0 anos, o tempo de medicação de 7,2±4,2 anos e a contagem de CD4 de 628,6±223,8 mm3 de sangue. A pontuação obtida no Escore de Framingham foi de 9,5±5,1 e o risco de eventos cardiovasculares foi de 9,5±7,9%, sendo 7 pacientes classificados como baixo risco, 14 como risco intermediário e 4 como alto risco cardiovascular. A pontuação do Escore de Framingham apresentou correlação com o tempo de medicação (r= 0,53), com o componente LFnu (r=0,45) e com a relação LF/HF (r=0,44), mas correlacionou-se inversamente com o SDNN (r=-0,43), rMSSD (r=-0,47) e com o índice triangular (r=-0,49). O risco de eventos cardiovasculares esteve correlacionado positivamente com o tempo de medicação (r=0,54), com o componente LFnu (r=0,45) e com a relação LF/HF (r=0,45), porém, apresentou correlação negativa com o SDNN (r=-0,40), rMSSD (r=-0,43) e com o índice triangular (r=-0,48). Conclusão: Pacientes portadores de HIV, classificados em diferentes faixas do Escore de Framingham, apresentam associação entre o risco cardiovascular e o aumento da atividade simpática, redução da atividade parassimpática e do balanço simpato-vagal. Isso demonstra que, mesmo em pacientes com carga viral não detectável, as disfunções autonômicas cardiovasculares podem estar associadas ao risco cardiovascular em dez anos. Estes achados apontam para a importância de avaliações rotineiras do sistema nervoso autonômico cardiovascular nesta população.
Ollila, M. M. (Meri-Maija). "The role of polycystic ovary syndrome (PCOS) and overweight/obesity in women’s metabolic and cardiovascular risk factors and related morbidities." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222592.
Повний текст джерелаTiivistelmä Munasarjojen monirakkulaoireyhtymä (polycystic ovary syndrome, PCOS) on lisääntymisikäisten naisten yleisin hormonaalinen häiriö aiheuttaen runsaasti sairastavuutta ja terveydenhuollon kustannuksia. PCOS:n diagnostisiin kriteereihin kuuluvat epäsäännöllinen kuukautiskierto, lisääntynyt miessukupuoli-hormonivaikutus sekä monirakkulaiset munasarjat. Merkittävä osa oireyhtymää sairastavista naisista on ylipainoisia tai lihavia ja oireyhtymän kanssa yhtä aikaa esiintyykin useita, ainakin osittain ylipainosta johtuvia, metabolisia häiriöitä. Lukuisista tutkimuksista huolimatta on kuitenkin epäselvää, altistaako PCOS itsessään metabolisille häiriöille sekä sydän- ja verisuonisairauksille. Väitöskirjatutkimuksen tavoitteena oli selvittää, onko PCOS itsenäinen metabolisten ja sydän- ja verisuonisairauksien riskiä lisäävä tekijä. Tutkimus pohjautui Pohjois-Suomen syntymäkohortti 1966 tutkimuksen 14-, 31- ja 46-vuotisseurantoihin. PCOS luokittelu perustui 31- ja 46-vuotiskyselyissä itse ilmoitettuihin tyypillisiin PCOS oireisiin ja/tai diagnoosiin. Tutkimuksessa havaittiin, että 14- ja 31-ikävuoden välillä tapahtuva painonnousu oli yhteydessä PCOS diagnoosiin myöhemmällä iällä. 46-vuotiaana normaalipainoisilla PCOS naisilla ei ollut suurentunut tyypin 2 diabetes riski, mutta painonnousu varhaisaikuisuudessa oli merkittävästi yhteydessä sokeriaineenvaihdunnan häiriöön PCOS naisilla. PCOS oli yhteydessä kohonneeseen verenpaineeseen 31-vuotiaana ja hypertensioon 46-vuotiaana ylipainosta riippumatta. Oireyhtymään liittyvät metaboliset häiriöt olivat tärkein sydämen autonomisen hermoston säätelyyn vaikuttava tekijää, kun taas PCOS itsessään ei vaikuttanut autonomisen hermoston toimintaan. PCOS:ään sairastavien naisten sydämen rakenne ja funktio eivät merkitsevästi poikenneet kontrolloiden vastaavista muuttujista. Kuitenkin suhteellisen nuoresta iästä huolimatta PCOS naisilla esiintyi enemmän sydäninfarkteja ja kaksi kertaa enemmän sydän- ja verisuonitapahtumia, kuin kontrolleilla. Tutkimuksen tulokset osoittavat, että vaikkakin PCOS on itsenäinen riskitekijä metabolisille häiriöille, oireyhtymään liittyvä ylipaino vaikuttaa merkittävästi metabolisten häiriöiden esiintymiseen. PCOS:n ja sydän- ja verisuonitautitapahtumien yhteyden tarkempi tutkiminen vaatii kohortin jatkoseurantaa. Painonhallinnan tukemisen tulisi olla PCOS:ää sairastavien naisten hoidon kulmakivi
Martin, Nailú Angélica Sinicato 1989. "Síndrome metabólica e composição corporal nos pacientes com lúpus eritematoso sistêmico juvenil." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312095.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Lupus Eritematoso Sistêmico (LES) e uma doença autoimune, crônica e mutissistemica, caracterizada por períodos de atividade e remissão. Anormalidades como leucopenia, anemia hemolítica, presença de auto-anticorpos como anti-DNA de fita dupla (anti-dsDNA), anti-Smith (anti-Sm) e fator antinuclear (FAN) podem ser encontradas. Quando diagnosticado ate os 16 anos de idade e denominado LESj. Devido ao elevado acometimeto cardíaco nesses pacientes e muito importante avaliar os fatores de risco para o desenvolvimento de doenças coronarianas. O presente estudo, de característica transversal, teve como objetivo avaliar a presença de SM nos pacientes com LESj e comparar com controles sem histórico de doença autoimune e cardiovasculares e avaliar a composição corporal e observar a associação com a atividade e dano da doença, uso de corticosteróides e TNF-?. Foram selecionados pacientes consecutivos com LESj acompanhados na Unidade de Reumatologia Pediátrica da UNICAMP entre 2010/2012. Manifestações clinicas, laboratoriais e medicação em uso foram avaliadas. A atividade da doença [SLE Disease Activity Index (SLEDAI)], dano cumulativo [Lupus International Collaborating Clinics (SLICC)] foi determinado para cada paciente no dia da coleta de sangue. A SM foi avaliada através do critério da IDF - International diabetes federation. A dosagem da citocina foi realizada por ELISA (Enzyme Linked Immuno Sorbent Assay). Observamos uma prevalência de SM de aproximadamente 20% dos pacientes incluídos. Observamos um numero similar de pacientes com LES <18 anos com síndrome metabólica quando comparada com ? 18 anos de idade (p = 0,202). Observamos que pacientes com LES <18 anos apresentaram mais hipertrigliceridemia e pacientes ? 18 anos apresentaram mais frequentemente hipercolesterolemia, altos níveis de LDL-C e hipertrigliceridemia, Observamos correlação do SLEDAI ajustado ao longo do tempo com a definição do IDF nos pacientes com LES ? 18 anos (r = 0,229, p = 0,033). Observamos também uma maior razão CA/CQ em pacientes com LESj quando comparado ao grupo controle (p <0,001). Observou-se correlação com o IMC e CA (r = 0,58, p <0,001) e CQ (r = 0,53, p <0,001) nos pacientes com LESj e entre IMC e peso (r = 0,86, p <0,001), altura (r = 0,26, p = 0,030), CA (r = 0,59, p <0,001) e CQ (r = 0,55, p <0,001) nos controles. Observamos uma correlação entre CA e IMC (r = 0,53, p <0,001) e o IAC (r = 0,39, p <0,001) nos pacientes com LESj. Observamos uma correlação entre o IAC e o IMC (r = 0,48, p <0,001). A analise da DXA mostrou que em pacientes com SLEj 36,8% de massa de corpo inteiro corresponde a gordura, e 42,3% esta localizada na região do tronco. Em nosso estudo observamos um aumento dos níveis séricos de TNF-? em pacientes com LESj, houve o aumento dos níveis de TNF-? em pacientes com doença ativa, alem de uma correlação positiva entre a pontuação de SLEDAI, níveis de TNF-? também se correlacionaram com a porcentagem de gordura e a massa gorda na região do tronco. De acordo com nossos resultados, os pacientes com LESj, possuem maior prevalência de SM e uma distribuição central de gordura corporal maior do que indivíduos controlem. Devido ao grande aumento do risco cardiovascular nesses pacientes e necessario a avaliacao rotineira da SM e da composição corporal
Abstract: Systemic lupus erythematosus (SLE) is a chronic, multisystemic, relapsing and remitting autoimmune disease. Abnormalities such as leukopenia, hemolytic anemia, presence of autoantibodies such as anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm) and antinuclear antibodies (ANA) can be found. When the diagnosis was made until 16 years old the patients was called childhood-onset SLE. Because of the greatest rate of cardiac involvement of these patients is very important to evaluate the risk factors to coronary diseases development The present cross-sectional study aimed to evaluate the presence of MetS in SLE patients and to compare with controls without autoimmune disease history and to evaluate the body composition and observe its association with the activity disease, laboratory data and corticosteroid treatment and TNF-?. We selected consecutive pediatric SLE patients followed at the Pediatric Rheumatology Unit of UNICAMP between 2010/2012. Clinical, laboratory, disease activity [SLE Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics / American College of Rheumatology Damage Index (SDI)] and current drug exposure were evaluated. The MetS was evaluated by IDF - International diabetes federation criteria. The measurement of cytokines was performed by ELISA (Enzyme Linked Immuno Sorbent Assay). The prevalence of MetS in approximately 20% of patients included. We observed a similar number of SLE patients <18 years with MetS compared with ? 18 years of age (p = 0.202). We found that SLE patients <18 years presented with hypertriglyceridemia and patients ? 18 years were more frequently hypercholesterolemia, high LDL-C and hypertriglyceridemia observed correlation of SLEDAI adjusted over time with the definition of the IDF in SLE patients ? 18 years (r = 0.229, p = 0.033). We also observed a higher ratio HC / WC procedures in patients with SLE compared to the control group (p <0.001). Correlation with BMI and WC (r = 0.58, p <0.001) and HC (r = 0.53, p <0.001) in patients with SLE and between BMI and weight (r = 0.86, p <0.001), height (r = 0.26, p = 0.030), WC (r = 0.59, p <0.001) and HC (r = 0.55, p <0.001) in controls. We observed a correlation between WC and BMI (r = 0.53, p <0.001) and BAI (r = 0.39, p <0.001) in patients with SLE. We observed a correlation between the BAI and BMI (r = 0.48, p <0.001). The DXA analysis showed that in patients with cSLE 36.8% by weight of the whole body matches the fat, and 42.3% is located in the trunk. In our study we observed an increase in serum levels of TNF-? in patients with cSLE, there were increased levels of TNF-? in patients with active disease, and a positive correlation between the SLEDAI score, levels of TNF-? also correlated with the percentage of fat and fat mass in the trunk region. According to our results, patients with cSLE, have a higher prevalence of MetS and a central distribution of body fat greater than control subjects. Due to the large involvement of CVD in these patients is necessary routine assessment of MetS and body composition
Mestrado
Pediatria
Mestra em Ciências
Almeida, Raitany Costa de 1977. "Hipertensão arterial sistêmica e outros fatores de risco cardiovascular em uma amostra da população de Porto Velho - RO = comparação urbana versus ribeirinha = Hypertesion and other cardiovascular risk factors in a sample of the population of Porto Velho - RO : urban area versus riverside area." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311543.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Hipertensão arterial sistêmica (HAS) é uma importante causa evitável de morbidade e mortalidade cardiovascular. Vários estudos apontam para o aumento de sua prevalência no mundo e baixo controle pressórico, mas existem poucos dados referentes as comunidades ribeirinhas. Esta pesquisa compara a prevalência, consciência, tratamento e controle de HAS entre população urbana e ribeirinha em Porto Velho, região Amazônica, assim como avalia outros fatores de risco cardiovascular. Foi conduzido um estudo transversal, fundamentado em inquérito domiciliar em indivíduos de 35 a 80 anos, recrutados entre julho e dezembro de 2013. Realizado entrevista com questionário padronizado, medidas de pressão arterial (PA), peso, altura e circunferência abdominal (CA). HAS foi definido através de indivíduos que relataram ter a doença, ou prescritos para uso de medicações anti-hipertensivas ou aqueles que tinham PA sistólica ? 140 mmHg ou PA diastólica ? 90 mmHg, na média de duas medidas usando dispositivo digital automático. Consciência foi baseada em autorrelatos, tratamento no uso de medicamento anti-hipertensivo, e controle foi definido quando indivíduos apresentavam PA menor do que 140/90 mmHg. Foi calculado índice de massa corpórea (IMC) e CA para avaliação de obesidade e obesidade abdominal. Também foi avaliado, através de autorrelatos, a taxa de diabetes, dislipidemia, tabagismo. Entre 1410 participantes, 750 (53,19%) tinham HAS e 473 (63,06%) eram cientes do diagnóstico. Daqueles que tinham consciência do diagnóstico, a maioria 404 (85.41%) recebia tratamento farmacológico, mas a taxa de controle foi baixa. As percentagens de prevalência e tratamento foram maiores na área urbana, respectivamente, (55,48% vs. 48,87%)(p=0,02) e (61,25% vs. 52,30%)(p<0,01). A consciência de HAS foi maior na área ribeirinha (61,05% vs. - 67,36%)(p<0,01), mas as taxas de controle, tanto entre todos os hipertensos quanto naqueles que faziam tratamento farmacológico, foram similares, respectivamente, (22,11% vs. 23,43%)(p=0,69) e (33,88% vs. 34,32%) (p=0,77). Não houve diferença significativa no sobrepeso (40,93% vs. 40,28%)(p=0,73); obesidade (19,10% vs 19,63%)(p=0,68) e tabagismo (18,56% vs. 16,76%)(p=0,09). Cerca de metade dos participantes apresentavam HAS. A prevalência foi mais alta nos urbanos, mas a diferença para os ribeirinhos foi pequena. Dos indivíduos hipertensos, tanto na área urbana quanto ribeirinha, menos de um quarto tinham HAS controlada
Abstract: High blood pressure (hypertension) is a major preventable cause of cardiovascular morbidity and mortality. Several studies indicate to the increase its prevalence in the world and low control rate, but there are few data on the riverside communities. This research compares the prevalence, awareness, treatment and control of hypertension between urban and riverside population in Porto Velho, the Amazon region, as well as evaluating other cardiovascular risk factors. A cross-sectional study was conducted, based on a household survey in individuals 35-80 years recruited between July and December 2013. Directed interview with standardized questionnaire, blood pressure measurements (PA), weight, height and waist circumference (WC). Hypertension was defined by individuals who reported having the disease, or prescribed for use of antihypertensive medications or those who had systolic blood pressure ? 140 mmHg or diastolic BP ? 90 mmHg, the mean of two measurements using automatic digital device. Awareness was based on self-reports, treatment in the use of antihypertensive medication, and control was defined as a BP ? 140/90 mm Hg. We calculated body mass index (BMI) and WC for assessing obesity and abdominal obesity. We also assessed through self-report, the rate of diabetes, dyslipidemia, smoking. Among 1410 participants, 750 (53.19%) had hypertension and 473 (63.06%) were aware of their diagnosis. Of those who were aware of the diagnosis, 404 (85.41%) received pharmacological treatment, but the control rate was low. The percentages of prevalence and treatment were higher in urban areas, respectively (55.48% vs. 48.87%) (p = 0:02) and (61.25% vs. 52.30%) (p <0.01). Awareness was higher in the riverside area (61.05% vs. 67.36%) (p <0.01), but control rates, both among all hypertensive patients and in those who were pharmacological treatment were similar, respectively, (22.11% vs . 23.43%) (p = 0.69) and (33.88% vs. 34.32%) (p = 0.77). - There was no significant difference in the overweight (40.93% vs. 40.28%) (p = 0.73); obesity (19.10% vs. 19.63%) (p = 0.68) and smoking (18.56% vs. 16.76%) (p = 0.09). Hypertension prevalence was higher in the urban population than in the riverside population. Of the hypertensive individuals in both areas, < 25% had controlled blood pressure
Doutorado
Clinica Medica
Doutor em Clínica Médica
Leboeuf, Charlotte. "Potential predictors and outcomes of physical activity : comparisons between physically active and inactive adolescent boys." Title page, table of contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09MPM/09mpml447.pdf.
Повний текст джерелаAl-Lage, Jéssica Guimarães. "Perfil epidemiológico, modulação autonômica cardíaca e escores de risco cirúrgico de indivíduos eletivos para cirurgia de revascularização do miocárdio /." Rio Claro, 2019. http://hdl.handle.net/11449/190800.
Повний текст джерелаResumo: Introdução: Em decorrência do número elevado de comorbidades associadas à Doença Arterial Coronariana (DAC), os modelos de previsão de risco para cirurgia cardíaca foram desenvolvidos com a finalidade de melhor caracterizar os fatores que influenciam os resultados deste procedimento. Além dos escores de risco utilizados mundialmente “European System for Cardiac Operative Risk Evaluation” (EUROSCORE II) e “Society of Thoracic Surgeons” (STS), a Variabilidade da Frequência Cardíaca (VFC) tem surgido como um novo instrumento de previsão do risco cardiovascular e cirúrgico. Objetivo: Caracterizar os pacientes eletivos para cirurgia de revascularização do miocárdio na região de Marília-SP-Brasil, quanto aos fatores de risco e controle neural do coração; Verificar se existe correlação entre os índices da VFC e os escores de risco cirúrgico EUROSCORE II e STS. Amostra: Foi composta por indivíduos de ambos os sexos, acima de 50 anos, eletivos para cirurgia de revascularização do miocárdio (Hospital Santa Casa de Misericórdia de Marília). O Grupo Controle (GC) foi composto por indivíduos de ambos os sexos, acima de 50 anos, saudáveis. Procedimentos do Estudo: Foi realizada a anamnese na qual foram avaliados os fatores de risco para doença cardiovascular. O registro do intervalos RR foi obtido na postura decúbito dorsal, por 20 minutos, em respiração espontânea. Os índices da VFC (lineares e não lineares) foram analisados, comparados com um grupo controle e correlacionados com valores ... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Introduction: Due to the high number of comorbidities associated with Coronary Artery Disease (CAD), risk prediction models for cardiac surgery were developed with the purpose of better characterizing the factors that influence the results of this procedure. In addition to the European System for Cardiac Operative Risk Evaluation (EUROSCORE II) and Society of Thoracic Surgeons (STS) worldwide, Heart Rate Variability (HRV) has emerged as a new tool for predicting cardiovascular risk and surgical. Objective: To characterize elective patients for myocardial revascularization surgery in the Marília-SP-Brazil region, regarding risk factors and neural control of the heart; To verify if there is a correlation between the HRV indices and the surgical risk scores EUROSCORE II and STS. Sample: It was composed of individuals of both sexes, over 50 years old, elective for myocardial revascularization surgery (Santa Casa de Misericórdia Hospital of Marília). The Control Group (CG) was composed of individuals of both genders, over 50 years, healthy. Study Procedures: An anamnesis was performed in which the risk factors for cardiovascular disease were evaluated. RR interval recording was obtained in the dorsal decubitus position for 20 minutes in spontaneous breathing. The HRV indices (linear and non-linear) were analyzed, compared to a control group and correlated with values obtained from EUROSCORE II and STS. The data were organized as descriptive statistics, with values of mean and stan... (Complete abstract click electronic access below)
Mestre
Pretorius, Jakobus. "Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease(NAFLD)." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71689.
Повний текст джерелаIncludes bibliography
ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) with inflammation (types 3,4). The aims of the study were 1) to analytically validate high-throughput real time polymerase chain reaction (RT-PCR) assays for three selected single nucleotide polymorphisms (SNPs), FTO rs9939609 (intron 1 T>A), TNF-α rs1800629 (-308 G>A) and PPARγ rs1801282 (Pro12Ala, 34 C>G), and 2) to perform genotype-phenotype association studies in relation to biochemical abnormalities, disease severity and age of onset. A total of 119 patients with fatty liver identified on ultrasound, including 88 histologically confirmed NAFLD patients, and 166 control individuals were genotyped for the three selected SNPs. RT-PCR validated against direct sequencing as the gold standard was used for detection of genetic variation. All three SNPs were in Hardy Weinberg equilibrium in the study population, except for a deviation in genotype distribution detected for PPARγ rs1801282 in the NAFLD patient subgroup (p<0.001). After adjustment for age and gender, the risk-associated FTO rs9939609 A-allele was detected at a significantly higher frequency in the Caucasian compared with Coloured patients (p=0.005). The opposite was detected for the risk-associated TNF-α rs1800629 A-allele, which occurred at a significantly higher frequency in the Coloured compared with Caucasian NAFLD patients (p=0.034). The onset of fatty liver disease symptoms was on average 5 years younger in the presence of each risk-associated TNF-α rs1800629 A-allele (p=0.028). When considered in the context of an inferred genotype risk score ranging from 0-6, disease onset occurred on average 3 years earlier (p=0.008) in the presence of each risk-associated FTO A-allele, TNF-α A-allele or PPARγ C-allele. After adjustment for age, gender and race, no differences in genotype distribution or allele frequencies were observed between histologically confirmed NAFLD (types 1,2) and NASH (types 3,4) patients, while the minor allele frequency for the TNF-α rs1800629 was significantly higher in the total NAFLD (types 1-4) (p=0.047) as well as NASH subgroup (NAFLD types 3,4) (p=0.030) compared with obese patients without a histologically confirmed NAFLD diagnosis. A significant correlation was furthermore observed between the number of TNF-α rs1800629 A-alleles and increasing CRP levels (p=0.029), with a favourable reduced effect in the presence of low- to moderate alcohol intake. The average waist circumference of physically active NAFLD patients was 12% lower than in physically inactive patients (p=0.004). In view of the results presented in this study, the inclusion of the selected SNPs, and in particular the pro-inflammatory TNF-α rs1800629 polymorphism, may be considered as part of a comprehensive cardiovascular risk evaluation of NAFLD patients. Ultimately, early detection of patients with fatty liver disease symptoms and effective intervention based on the underlying disease mechanism may prevent progression from NAFLD to NASH, shown to be an independent risk factor for cardiovascular diseases.
AFRIKAANSE OPSOMMING: Nie-alkoholiese lewervervetting (NALV) is die mees algemene kroniese lewersiekte in die wêreld. Die siektespektrum van NALV strek van steatose (vervette lewer tipes 1,2) tot steatohepatitis met inflammasie (NASH tipes 3,4). Die doel van die studie was 1) om analities die hoë omset polimerase kettingreaksie (RT-PKR) metode te valideer vir die geselekteerde enkel nukleotied polimorfismes (ENPs) FTO rs9939609 (intron 1 T>A), TNF-α rs1800629 (-308 G>A) en PPARγ rs1801282 (Pro12Ala, 34 C>G), en 2) om genotipe-fenotipe assosiasie studies uit te voer ten opsigte van relevante biochemiese abnormaliteite, graad van die siekte en aanvangsouderdom. ’n Totaal van 119 pasiënte met vervette lewers is geïdentifiseer met behulp van ultraklank, insluited 88 histologies-bevestigde NALV pasiënte, en 166 kontrole individue. Hierdie pasiënte is gegenotipeer vir die 3 geselekteerde ENP’s. RT-PKR gevalideer met direkte DNA volgorde bepaling as die goue standaard, is gebruik vir opsporing van genetiese variasie. Al die ENP’s was in Hardy Weinberg ekwilibrium in die studie populasie, behalwe vir ’n afwyking in genotipe verspreiding waargeneem vir PPARγ in die NALV subgroep (p<0.001). Nadat aanpassings gemaak is vir ouderdom en geslag, is die risiko-geassosieerde FTO rs9939609 A-alleel waargeneem teen ’n betekenisvol hoër frekwensie in die Kaukasiese pasiënte in vergelyking met Kleurling pasiënte (p=0.005). Die teenoorgestelde is waargeneem vir die risiko-geassosieerde TNF-α rs1800629 A-alleel wat voorgekom het teen ’n betekenisvol hoër frekwensie in die Kleurling NALV pasiënte, in vergelyking met Kaukasiese NALV pasiënte (p=0.034). Die aanvang van NALV was gemiddeld 5 jaar vroeër in die teenwoordigheid van elke risiko-geassosieerde TNF-α rs1800629 A-alleel (p=0.028). Met inagneming van ’n genotipe risiko telling tussen 0–6, het aanvang van siekte gemiddeld 3 jaar vroeër voorgekom (p=0.008) in die teenwoordigheid van elke toenemende risiko-geassosieerde FTO A-alleel, TNF-α A-alleel en PPARγ C-alleel. Nadat aanpassings gemaak is vir ouderdom, geslag en ras, is geen verskille waargeneem in genotipe verspreiding of alleel frekwensies tussen histologies bevestigde NALV (tipes 1,2) en NASH (tipes 3,4) pasiënte nie, terwyl die minor alleel telling vir die TNF-α rs1800629 betekenisvol hoër was in die totale NALV (tipes 1–4) (p=0.047) asook die NASH subgroep (NALV tipes 3,4) (p=0.03) in vergelyking met vetsugtige pasiënte sonder ’n histologies bevestigde diagnose. ‘n Statisties beteknisvolle korrelasie is verder waargeneem tussen die aantal TNF-α rs1800629 A-allele en toenemende CRP vlakke (p=0.029), met n gunstige verlaagde effek in die teenwoordigheid van lae alcohol gebruik. Die gemiddelde middellyf-omtrek van fisies aktiewe NALV pasiënte was 12% minder as fisies onaktiewe pasiente (p=0.004). Na aanleiding van die resultate van hierdie studie behoort insluiting van geselekteerde ENP’s, en in besonder die pro-inflammatoriese TNF-α rs1800629 polimorfisme, as deel van ’n omvattende kardiovaskulere risiko evaluasie oorweeg te word. Aan die einde van die dag mag vroeë identifikasie van NALV pasiente en effektieve intervensie gebasseer op die onderliggende siekte meganisme, vordering tot NASH verhoed wat getoon is om ’n onafhanklike risiko faktor vir kardiovaskulêre siekte te wees.
Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology
Rodrigues, Sara. "Avaliação da rigidez arterial e da resistência vascular periférica em pacientes recém-diagnosticados com síndrome metabólica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-24102016-115125/.
Повний текст джерелаBesides autonomic alterations, metabolic syndrome (MetS) causes vascular dysfunction related to cardiovascular events and death. Since insulin resistance is associated with sympathetic hyperactivation, we tested the hypothesis that the presence of impaired fasting glucose (IFG) is the main cause of structural and functional changes of large and small vessels via elevated sympathetic tonus in these patients. We evaluated never treated, newly diagnosed MetS (ATP-III) patients divided into: impaired fasting glucose >100mg/dL (MetS+IFG, n=35; 50±1 y) and normal fasting glucose <100mg/dL (MetS-IFG, n=24, 46±1 y). A healthy control group was also studied (C, n=17, 50±1 y). We measured the arterial stiffness (pulse wave velocity, PWV), muscle sympathetic nerve activity (MSNA, microneurography), forearm blood flow (FBF, plethysmography), mean blood pressure (MBP, oscillometric), peripheral vascular resistance (PVR=MBP/FBF) and asymmetric dimethylarginine (ADMA). MetS+IFG had higher PWV than MetS-IFG and C (8.0[7.2-8.6], 7.3[6.9-7.9] and 6.9[6.6-7.2]m/s, respectively, P=0.001), whereas SMet-GLI was similar to CS. Moreover, MetS+IFG was similar to MetS-IFG, but had higher PVR than C (P=0.008) and SMet-GLI was similar to CS. In addition, MetS+IFG had higher MSNA than MetS-IFG and C; whereas MetS-IFG had higher MSNA than C (31 +- 1; 26+- 1; 19+-1 bursts/min, P < 0.001). ADMA were similar among groups (0.62 [0.56-0.71] vs 0.67 [0.59-0.92] and 0.60 [0.54-1.43] umol/L). Among MetS risk factors, IFG was predictor of increased MSNA. Further, MSNA was associated with PWV (R=0.39; P=0.002) and PVR (R=0.30, P=0.034). In conclusion, sympathetic hyperactivation, which is enhanced in the presence of high blood glucose, is the basic mechanism that could explain, at least in part, the increase in PWV and PVR. IFG appears to be the main risk factor in the vascular function and structure damage in MetS patients
Pizzi, Oswaldo Luiz. "Velocidade da onda de pulso em adultos jovens acompanhados por 18 anos: impacto de variáveis pressóricas, antropométricas, metabólicas, inflamatórias e de função endotelial. Estudo do Rio de Janeiro." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4851.
Повний текст джерелаData on non-invasive evaluation of vascular stiffness in the young and its relationship with cardiovascular (CV) risk variables are scarce. Objective to assess the relationship between pulse wave velocity (PWV) and blood pressure (BP), anthropometric, metabolic, inflammatory and endothelial dysfunction variables in young adults. Ninety-six individuals (51 males) from The Rio de Janeiro Study cohort were studied in two evaluations, A1 and A2, with an interval of 17.69 1.58 years (16-21 years). In A 1 they were evaluated at their schools (10-15 years average 12.42 1.47 years) and in A2 they were all re-evaluated as outpatients (26-35 years - average 30.09 1.92 years). In A1 BP and body mass index (BMI) were obtained. In A2 pulse wave velocity (PWV) by Complior method, BP, BMI, waist circumference (WC), glucose, lipid profile, leptin, insulin, adiponectin, the HOMA-IR insulin resistance index, high sensitive C-Reactive protein (CRPhs) and E-selectin, Vascular Cell Adhesion Molecule 1 (VCAM-1) and Intercellular Adhesion Molecule 1 (ICAM-1) adhesion molecules were obtained. The BP and BMI variation over the time interval between the two evaluations were also obtained. Subjects were stratified according to tertile of PWV for each sex in A2. As results: 1) The groups were constituted as follows: Tertile 1: males with PWV <8.69 m/s and females with PWV <7.66 m/s; Tertile 2: males with PWV ≥ 8.69 m/s and <9.65 m/s and females with PWV ≥ 7.66 m/s and <8.31 m/s; Tertile 3: males with PWV ≥ 9.65 m/s and females with PWV ≥ 8.31 m/s 2) The group with the highest PWV tertile showed higher values of systolic BP (SBP) (p=0.005), diastolic BP (DBP) (p=0.007), mean BP (MBP) (p=0,004), DBP variation (p=0,032), MBP variation (p=0.033), BMI (p=0.046), BMI variation (p=0.020), insulin (p=0.019), HOMA-IR (p=0.021), E-Selectin (p=0.032) and lower values of adiponectin (p=0.016), besides higher prevalence of diabetes mellitus/glucose intolerance (p=0.022) and hyperinsulinemia (p=0.038); 3) There were a significant positive correlation of PWV with SBP (p<0,001), DBP (p<0,001), PP (p=0,048) and MBP (p<0,001) from A2, variation in blood pressure (SBP, DBP, and MBP) (p<0,001) between the two assessments, BMI (p=0.005) and BMI variation between the two evaluations (p<0,001), WC (p=0.001), LDL-cholesterol (0.049), and E-selectin (p<0,001) and negative correlation with HDL-cholesterol (p<0,001) and adiponectin (p<0,001); 4) In the multiple regression model, HDL-cholesterol, LDL-cholesterol and adiponectin lost statistical significance after adjustment for sex, age, BMI and MBP, only the male gender and MBP remained significantly correlated with PWV. PWV in young adults showed a significant association with CV risk variables, highlighting the male gender and MBP as important variables in its determining. The findings suggest that measurement of PWV can be useful for the identification of vascular impairment in this age group.
Bennett, Stanley Arthur. "Trends and social inequalities in cardiovascular risk factors." Phd thesis, 1996. http://hdl.handle.net/1885/143647.
Повний текст джерелаMiller, Kelli A. "The relationship of sociocultural factors and lifestyle cognitive representations to cardiovascular risk factors." 1998. http://catalog.hathitrust.org/api/volumes/oclc/166884767.html.
Повний текст джерела"Work-related stress and cardiovascular risk factors in Chinese." 2004. http://library.cuhk.edu.hk/record=b6073711.
Повний текст джерела"April 2004."
Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.
Includes bibliographical references (p. 159-175)
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Mode of access: World Wide Web.
Abstracts in English and Chinese.
Mui, Suet-Lam. "A cardiovascular disease policy model for Australia using a microsimulation approach." Phd thesis, 1999. http://hdl.handle.net/1885/147334.
Повний текст джерелаMunthali, Richard Junganiko. "Longitudinal analysis of genetic risk factors for cardiovascular disease: the birth to twenty plus cohort." Thesis, 2017. http://hdl.handle.net/10539/23491.
Повний текст джерелаNon-communicable diseases (NCDs) pose an increasing burden on public health and economic growth worldwide. The highest increase in prevalence and death rates of NCDs has been seen in low and middle-income countries (LMICs). World Health Organization (WHO) estimates that by 2030, NCDs will account for five times as many deaths as communicable diseases in LMICs and that there will be more than 2.16 billion overweight and 1.12 billion obese individuals in the world. It is also estimated that by 2020 NCDs will contribute 80 percent of the global burden of disease and the largest increase in NCD deaths will occur in Africa. Recent reports indicate that six of the ten leading natural causes of death in South Africa are NCDs. There are few studies that have used longitudinal data to understand the effects of life-course childhood adiposity on future health risks and the early life factors responsible for variations in lifecourse childhood obesity. However, it is not known whether there is a genetic basis for the variability in BMI developmental patterns over time. Lack of comprehensive longitudinal and genetic association data for obesity have made it difficult to do such studies in an African setting. It is still not clear whether the same genetic variants associated with obesity in Europeans and other populations are also associated with these traits in African populations. Understanding the genetic contribution to obesity in the black South African population may help to come up with effective interventions to deal with this emerging epidemic in Africa. The aim of this thesis was to better understand the contribution of genetics and explain the longitudinal genetic basis of childhood and adolescence obesity in black South African children. To deal with this, I firstly studied identification of distinct trajectories of BMI and then relate the established BMI trajectories to the future health risks of elevated blood pressure. Secondly, I explored the early life factors behind BMI trajectory membership, this would help to identify factors that may accelerate an individual’s progression from a normal BMI trajectory pattern membership to the one characterized with elevated BMI. Then lastly, I looked at the additive genetic effect for BMI and determine whether genetic risk of obesity in early adulthood was mediated by early life rapid growth. Results showed variation in BMI developmental patterns between boys and girls; three and four distinct sex-specific BMI trajectories were identified in boys and girls respectively. Children belonging to early onset overweight or obese BMI trajectories, characterized by elevated BMI, had an increased risk of elevated blood pressure in late adolescence, compared to their peers in the normal trajectories. Rapid conditional relative weight gain in early life was associated with increased risk of belonging to a BMI trajectory characterized by consistent elevated BMI over time. Individuals in overweight or obese trajectories had a higher chance of being overweight or obese in early adulthood. I found that a genetic risk score, based on known adult BMI Caucasian risk variants, showed significant longitudinal effects of genetic loci with BMI in childhood and adolescent and significant age-GRS interactions were observed. A higher genetic risk score predicted membership of early onset obese or overweight BMI trajectories. The genetic risk of obesity at 18 years of age was mediated by pre-adolescence and adolescence rapid weight gain. The results from this thesis emphasize the importance of studying individual’s BMI developmental patterns when studying development and progression of obesity. These findings also show that the information obtained from GWAS done in other populations can be equally relevant to African populations and this could be used in early identification of individuals at increased risk of obesity and other NCDs risk factors. Combing genetic risk score, BMI trajectories membership and weight status can be used to help improve the screening process of individuals to be targeted in coming up with targeted educational and behavior intervention programmes for obesity. These programmes should target individuals at risk at early stage in order to reduce the adverse health risk outcomes later in life.
MT 2017
Moore, Vivienne Marie. "Fetal growth and cardiovascular risk factors in an Australian cohort / Vivienne Moore." Thesis, 1997. http://hdl.handle.net/2440/19017.
Повний текст джерелаxv, 212 leaves ; 30 cm.
The present study investigates the relationships between fetal growth, as manifest in size and shape at birth, and later blood pressure and blood lipids, in an Australian cohort. Data on these outcomes for cohort members at age 8 years are available from a previous study. Birth details (body weight, placental weight, head circumference, chest circumference and length) are abstracted from hospital records. In addition, a follow up of cohort members is undertaken to collect new data pertaining to the two cardiovascular risk factors at 20 years of age. Socio-economic circumstances are characterised at birth, age 8 and age 20.
Thesis (Ph.D.)--University of Adelaide, Dept. of Public Health, 1997?
"Microalbuminuria, heavy metals and cardiovascular risk factors in Hong Kong Chinese school children." 2011. http://library.cuhk.edu.hk/record=b5894630.
Повний текст джерелаThesis (M.Phil.)--Chinese University of Hong Kong, 2011.
Includes bibliographical references (leaves 83-103).
Abstracts in English and Chinese.
Abstract --- p.I
摘要 --- p.VI
Chapter Chapter 1 --- Background --- p.1
Chapter 1.1 --- Introduction --- p.1
Chapter 1.2 --- Albuminuria --- p.3
Chapter 1.2.1 --- Definition --- p.3
Chapter 1.2.2 --- Albuminuria in adolescents/children --- p.6
Chapter 1.2.3 --- Prevalence of albuminuria in adults and adolescents --- p.8
Chapter 1.2.4 --- Pathogenesis of albuminuria --- p.10
Chapter 1.3 --- CVD and risk factors --- p.12
Chapter 1.4 --- The associations between microalbuminuria and CVD risk factors --- p.17
Chapter 1.5 --- Heavy metals --- p.18
Chapter 1.5.1 --- Definition of heavy metals --- p.18
Chapter 1.5.2 --- Adverse effects of heavy metals --- p.19
Chapter 1.5.3 --- Heavy metals exposure In Hong Kong population: the local scene --- p.28
Chapter 1.6 --- MicroRNAs --- p.29
Chapter 1.6.1 --- The discovery of microRNAs --- p.29
Chapter 1.6.2 --- The biogenesis of microRNAs --- p.30
Chapter 1.6.3 --- The function of microRNAs --- p.31
Chapter 1.7 --- Hypothesis --- p.40
Chapter Chapter 2 --- Methodology --- p.41
Chapter 2.1 --- Population --- p.41
Chapter 2.2 --- Laboratory assays --- p.42
Chapter 2.3 --- Statistical analysis --- p.44
Chapter Chapter 3 --- Results --- p.46
Chapter 3.1 --- Demographic and baseline clinical data --- p.46
Chapter 3.2 --- Microalbuminuria and cardiovascular risk factors --- p.48
Chapter 3.3 --- Microalbuminuria and heavy metals --- p.51
Chapter 3.4 --- Microalbuminuria and miRNAs --- p.54
Chapter 3.5 --- "Microalbuminuria, miRNAs, heavy metals and cardiovascular risk factors" --- p.57
Chapter 3.6 --- miRNAs and heavy metals --- p.60
Chapter Chapter 4 --- Discussion --- p.62
Chapter 4.1 --- Heavy metals and microalbuminuria --- p.62
Chapter 4.2 --- Heavy metals and CVD risk factors --- p.68
Chapter 4.3 --- Microalbuminuria and CVD risk factors --- p.75
Chapter 4.4 --- miRNAs and Heavy metals --- p.76
Chapter 4.5 --- miRNAs and microalbuminuria --- p.77
Chapter 4.6 --- Conclusion --- p.79
Acknowledgement --- p.82
References --- p.83
"Cardiovascular complications of childhood obstructive sleep apnea syndrome." 2007. http://library.cuhk.edu.hk/record=b5893248.
Повний текст джерелаThesis (M.Phil.)--Chinese University of Hong Kong, 2007.
Includes bibliographical references (leaves xxvii-lv).
Abstracts in English and Chinese.
ACKNOWLEDGEMENTS --- p.i
ABSTRACT
In English --- p.ii
In Chinese --- p.v
LIST OF TABLES --- p.vii
ABBREVIATIONS
For Units --- p.ix
For Prefixes of the international system of units --- p.ix
For Terms commonly used in the report --- p.x
STATEMENT OF WORK DONE --- p.xvi
Chapter CHAPTER 1 --- Overview of Childhood Obstructive Sleep Apnea Syndrome (OSAS)
Chapter 1.1. --- Clinical Features of Childhood OSAS --- p.1
Chapter 1.2. --- Definition of Childhood OSAS --- p.2
Chapter 1.3. --- Prevalence of Childhood OSAS --- p.3
Chapter 1.4. --- Pathophysiology --- p.4
Chapter 1.5. --- Risk Factors --- p.6
Chapter 1.6. --- Diagnosis --- p.10
Chapter 1.7. --- Treatment
Chapter 1.7.1. --- Tonsillectomy and Adenoidectomy (T&A) --- p.12
Chapter 1.7.2. --- Continuous Positive Airway Pressure (CPAP) --- p.14
Chapter 1.7.3. --- Corticosteroids --- p.15
Chapter 1.7.4. --- Leukotriene Receptor Antagonist --- p.16
Chapter 1.8. --- Complications of Childhood OSAS
Chapter 1.8.1. --- Growth Failure --- p.17
Chapter 1.8.2. --- Neurocognitive Abnormalities --- p.19
Chapter 1.8.3. --- Cardiovascular Abnormalities --- p.20
Chapter CHAPTER 2 --- Cardiovascular Complications of OSAS in Adults (Literature Review)
Chapter 2.1. --- Acute Effects of OSAS on Cardiovascular System --- p.21
Chapter 2.2. --- Chronic Effects of OSAS on Cardiovascular System --- p.23
Chapter 2.3. --- Hypertension --- p.24
Chapter 2.4. --- Heart Failure --- p.28
Chapter 2.5. --- Pulmonary Hypertension --- p.30
Chapter 2.6. --- Arrhythmias --- p.31
Chapter 2.7. --- Cardiac Ischemia and Vascular Disease --- p.33
Chapter 2.8. --- Stroke --- p.34
Chapter CHAPTER 3 --- Cardiovascular Complications of Childhood OSAS (Literature Review)
Chapter 3.1. --- Blood Pressure --- p.37
Chapter 3.2. --- Ventricular Structure and Function --- p.40
Chapter 3.3. --- Arterial Distensibility --- p.42
Chapter 3.4. --- Heart Rate Variability --- p.42
Chapter CHAPTER 4 --- Ambulatory Blood Pressure in Children with OSAS
Chapter 4.1. --- Introduction --- p.44
Chapter 4.2. --- Methods
Chapter 4.2.1. --- Subjects and Study Design --- p.46
Chapter 4.2.2. --- Polysomnography (PSG) --- p.47
Chapter 4.2.3. --- Ambulatory Blood Pressure Measurement (ABPM) --- p.49
Chapter 4.2.4. --- Statistical Analysis --- p.50
Chapter 4.3. --- Results
Chapter 4.3.1. --- Subject Characteristics --- p.52
Chapter 4.3.2. --- Blood Pressure during Wakefulness --- p.55
Chapter 4.3.3. --- Blood Pressure during Sleep --- p.57
Chapter 4.4. --- Discussion --- p.62
Chapter 4.5. --- Conclusion --- p.70
Chapter CHAPTER 5 --- Cardiac Remodeling and Dysfunction in Children with OSAS
Chapter 5.1. --- Introduction --- p.71
Chapter 5.2. --- Methods
Chapter 5.2.1. --- Subjects and Study Design --- p.72
Chapter 5.2.2. --- Polysomnography (PSG) --- p.74
Chapter 5.2.3. --- Conventional Echocardiography --- p.75
Chapter 5.2.4. --- Tissue Doppler Imaging --- p.76
Chapter 5.2.5. --- Statistical Analysis --- p.77
Chapter 5.3. --- Results
Chapter 5.3.1. --- Study Population --- p.79
Chapter 5.3.2. --- Polysomnographic Findings --- p.79
Chapter 5.3.3. --- Echocardiographic Findings
Chapter 5.3.3.1. --- Right Ventricle --- p.81
Chapter 5.3.3.2. --- Left Ventricle --- p.83
Chapter 5.3.4. --- Treatment Effect --- p.86
Chapter 5.4. --- Discussion --- p.90
Chapter 5.5. --- Conclusion --- p.95
Chapter CHAPTER 6 --- Conclusion --- p.96
APPENDIX I Hong Kong Children Sleep Questionnaire (Chinese) --- p.xvii
APPENDIX II Hong Kong Children Sleep Questionnaire (English) --- p.xxii
REFERENCES --- p.xxvii
Sengwayo, Duduzile Gladys. "The prevalence of arterial thrombosis predisposing risk parameters in a rural black community in the Limpopo province." Thesis, 2012. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000286.
Повний текст джерелаAims to assess the prevalence rates of hyperlipidaemia, hyperglycaemia, elevated homocysteine levels, elevated FVII levels and high blood pressure, as risk parameters of arterial thrombosis, in a rural black community in the Limpopo Province South Africa.
"Follow-up study of childhood obstructive sleep apnoea syndrome: a cardiovascular perspective." 2010. http://library.cuhk.edu.hk/record=b5894309.
Повний текст джерелаThesis (M.Phil.)--Chinese University of Hong Kong, 2010.
Includes bibliographical references (leaves xvi-xlviii).
Abstracts in English and Chinese.
ACKNOWLEDGEMENTS --- p.i
ABSTRACT
In English --- p.ii
In Chinese --- p.iv
LIST OF TABLES --- p.vi
LIST OF FIGURE --- p.viii
ABBREVIATIONS
For Units --- p.ix
For Prefixes of the International System of Units --- p.ix
For Terms Commonly Used --- p.X
Chapter CHAPTER 1 --- Overview of Childhood Obstructive Sleep Apnoea Syndrome (OSAS)
Chapter 1.1 --- Prevalence --- p.1
Chapter 1.2 --- Clinical Features --- p.3
Chapter 1.3 --- Definitions and Cutoffs --- p.4
Chapter 1.4 --- Pathophysiology --- p.6
Chapter 1.5 --- Risk Factors
Chapter 1.5.1 --- Gender --- p.8
Chapter 1.5.2 --- Obesity --- p.9
Chapter 1.5.3 --- Adenotonsillar Hypertrophy --- p.10
Chapter 1.5.4 --- Genetic --- p.11
Chapter 1.5.5 --- Atopic Diseases --- p.12
Chapter 1.6 --- Complications
Chapter 1.6.1 --- Neurobehavioural Deficits --- p.13
Chapter 1.6.2 --- Growth Defects --- p.14
Chapter 1.6.3 --- Metabolic Disorders --- p.16
Chapter 1.6.4 --- Systemic inflammation --- p.17
Chapter 1.6.5 --- Cardiovascular Consequences --- p.19
Chapter 1.7 --- Diagnosis --- p.20
Chapter 1.8 --- Treatment
Chapter 1.8.1 --- Surgical Treatment --- p.22
Chapter 1.8.2 --- Continuous Positive Airway Pressure (CPAP) --- p.24
Chapter 1.8.3 --- Corticosteroids --- p.24
Chapter 1.8.4 --- Leukotriene Receptor Antagonist --- p.25
Chapter 1.8.5 --- Oral Appliances --- p.26
Chapter 1.8.6 --- Weight Control --- p.27
Chapter CHAPTER 2 --- OSAS and Cardiovascular Complications in Adults
Chapter 2.1 --- Mechanism
Chapter 2.1.1 --- Acute Cardiovascular Responses --- p.28
Chapter 2.1.2 --- Chronic Cardiovascular Responses --- p.29
Chapter 2.2 --- Hypertension
Chapter 2.2.1 --- Epidemiological and Clinical Data --- p.31
Chapter 2.2.2 --- Characteristics --- p.32
Chapter 2.2.3 --- Mechanisms --- p.33
Chapter 2.2.4 --- Treatment --- p.34
Chapter 2.3 --- Heart Failure --- p.35
Chapter 2.4 --- Stroke --- p.37
Chapter 2.5 --- Cardiac Arrhythmias --- p.39
Chapter 2.6 --- Myocardial Ischemia and Vascular Disease --- p.41
Chapter 2.7 --- Pulmonary Hypertension --- p.43
Chapter CHAPTER 3 --- OSAS and cardiovascular complication in children
Chapter 3.1 --- Blood Pressure --- p.45
Chapter 3.2 --- Ventricular Hypertrophy and Dysfunctions --- p.48
Chapter 3.3 --- Heart Rate Variability --- p.50
Chapter 3.4 --- Arterial Tone --- p.51
Chapter 3.5 --- Endothelial Function --- p.51
Chapter CHAPTER 4 --- Longitudinal follow-up study of children with OSAS - a cardiovascular perspective
Chapter 4.1 --- Introduction --- p.53
Chapter 4.2 --- Methods
Chapter 4.2.1 --- Subjects and Study Design --- p.57
Chapter 4.2.2 --- Polysomnography --- p.59
Chapter 4.2.3 --- Ambulatory Blood Pressure Measurement --- p.61
Chapter 4.2.4 --- Statistical Analysis --- p.62
Chapter 4.3 --- Results
Chapter 4.3.1 --- Subject Characteristics --- p.64
Chapter 4.3.2 --- Blood Pressure During Wakefulness --- p.71
Chapter 4.3.3 --- Blood Pressure During Sleep --- p.76
Chapter 4.3.4 --- Nocturnal Blood Pressure Dipping --- p.83
Chapter 4.3.5 --- Blood Profile --- p.86
Chapter 4.4 --- Discussion --- p.87
Chapter 4.5 --- Conclusion --- p.99
Reference List --- p.xvi
"Pharmacogenetics of rosuvastatin therapy and genetic determinants of some cardiovascular risk factors in Chinese patients." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074864.
Повний текст джерелаSome novel genetic determinants of the LDL-C response to rosuvastatin treatment have been identified in this study. The responses in HDL-C and triglycerides were related more closely to the baseline levels of these lipids than to any of the polymorphisms examined. Genetic associations with baseline lipid parameters, hsCRP, uric acid and bilirubin were identified and generally correspond with some of the previous reports of studies in Chinese and other ethnic groups.
The key findings of the study are as follows: 1. The polymorphisms most highly associated with the low-density lipoprotein cholesterol (LDL-C) response were 421C>A in the ATP-binding cassette G2 (ABCG2) gene (P=9.2x10 -7), followed by 18281G>A (V257M) in the flavin-containing monooxygenase 3 (FMO3) gene (P=0.0002), 1421C>G in the lipoprotein lipase (LPL) gene (P=0.002), and rs4420638 in the apolipoprotein E/C-I/C-IV/C-II (APOE/C1/C4/C2) gene cluster (P=0.004). These genetic polymorphisms and having FH totally explained 13.6% of the variance in percentage change in LDL-C in response to rosuvastatin. The greater percentage reduction in LDL-C in patients with the ABCG2 421AA genotype compared to those with the ABCG2 421CC genotype was equivalent to at least doubling the dose of rosuvastatin. 2. Three SNPs (glucokinase regulator [ GCKR] rs1260326, apolipoprotein AS [APOA5] -1131T>C and the solute carrier organic anion transporter 1B1 [SLCO1B1] 521T>C) tended to be associated with percentage changes in high-density lipoprotein cholesterol (HDL-C) (P<0.05), but none of these reached the overall significance level. In multivariate stepwise regression analysis, baseline HDL-C (P=1.6x10 -6), having diabetes (P=0.0004) or RA (P=0.002) and the SLCO1B1 521T>C polymorphism (P=0.03) were determinants of HDL-C responses, contributing 9.9% of the variance in percentage change in HDL-C, but the genetic factors only contributed to 0.8% of the variance. 3. The triglyceride response to rosuvastatin was highly variable and was strongly related to baseline levels. The diacylglycerol acyltransferase-2 (DGAT2) rs10899113 C>T polymorphism tended to be associated with reduced triglyceride response in a gene-dose dependent manner. However, in multivariate stepwise regression analysis, baseline triglyceride level was the only factor that strongly related to the triglyceride response, explaining 14.4% of the variance. 4. This study has also analyzed relationships between on-treatment plasma hsCRP concentrations and cardiovascular risk factors and 14 single nucleotide polymorphisms in CRP and other candidate genes, which showed that central obesity, low HDL-C and CRP polymorphisms are major determinants of higher hsCRP levels in Chinese patients on treatment with rosuvastatin. 5. The association between genetic polymorphisms and lipid traits were analyzed in FH and non-FH patients separately due to their different lipid profiles. The analysis has shown that there were different genetic predictors of lipid levels in patients with and without FH and that more genetic factors appeared to affect the baseline lipid levels in patients with FH compared to non-FH patients, suggesting complex interactions between genetic and environmental factors and plasma cholesterol levels in patients with and without FH. 6. The SLC2A9 (solute carrier family 2, member 9) rs1014290 T>C was significantly associated with plasma uric acid levels in a gene-dose dependent manner (P=1.0x10-5) and the relationship was more pronounced in women or in patients without hypertension than in men or patients with hypertension. The ABCG2 421 C>A did not show a significant effect on uric acid levels. 7. The UGT1A1 (uridine diphosphate glucuronosyltransferases family, polypeptide A1) variants *28 (P=1.5x10 -9) and *6 (P=2.2x10-7) were independently associated with increased baseline bilirubin levels. Polymorphisms in SLCO1B1 did not appear to affect bilirubin levels in this study.
Hu, Miao.
Adviser: Brian Tomlinson.
Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .
Thesis (Ph.D.)--Chinese University of Hong Kong, 2010.
Includes bibliographical references (leaves 230-264).
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstract also in Chinese.
Adelekan, Adeboye Mutiu. "Establishment of screening procedures for genetic disorders and risk factors in the South African Caucasian population." Diss., 2003. http://hdl.handle.net/2263/26738.
Повний текст джерелаMotsko, Stephen Paul. "The relationship between Cox-2 inhibitors and cardiovascular risk: a retrospective analysis using the Veteran Affairs (VA) database." Thesis, 2005. http://hdl.handle.net/2152/1637.
Повний текст джерелаPalma, Anton. "Cardiovascular Disease Risk Behaviors in Human Immunodeficiency Virus-Positive Populations: Exploring a Stress-Coping Hypothesis." Thesis, 2020. https://doi.org/10.7916/d8-b7n0-n029.
Повний текст джерелаBordelois, Paula M. "Internalizing and Externalizing Behavior Problems in Childhood and Early Development of Cardiovascular and Diabetes Risk: A Life Course Perspective." Thesis, 2019. https://doi.org/10.7916/d8-71rm-m138.
Повний текст джерелаSan, Miguel Michelle M. "The relationship between Lp-PLA2 mass and activity and carotid intima media thickness (CIMT) in women." 2010. http://liblink.bsu.edu/uhtbin/catkey/1610825.
Повний текст джерелаAccess to thesis permanently restricted to Ball State community only
School of Physical Education, Sport, and Exercise Science