Дисертації з теми "Cardiovascular Disease Mortality"
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Goh, Gek Huang Louise. "Risk score for predicting cardiovascular disease mortality in Australian women." Thesis, Curtin University, 2014. http://hdl.handle.net/20.500.11937/223.
Повний текст джерелаDeniz, Nathalie. "Ethnicity and Cardiovascular Disease in theMiddle East." Thesis, Högskolan i Gävle, Avdelningen för arbets- och folkhälsovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-14691.
Повний текст джерелаSyftet med denna studie var att jämföra mellan etniska grupper om det finns en skillnad i överlevnad och behandling när det gäller hjärt-och kärlsjukdomar i Mellanöstern. För att ta reda på det har 28 artiklar valts ut efter inklusionskriterierna, både kvalitativa och kvantitativa studier. Sökningar gjordes i databaserna Medline, Pubmed, Google and Google Scholar.Resultatet visade på att det sannolikt finns skillnader i dödlighet samt sjuklighet mellan etniciteter som drabbats av hjärt- och kärlsjukdomar. Dessa kan bero på skillnader i abdominal fetma, insulin resistens vid diabetes och andra risker så som C-reaktivt protein som finns i blodplasman och i vanliga fall utsöndras vid inflammationer i kroppen och adiponectin som är ett hormon som finns i fettvävnaden vars utsöndring är sämre hos personer som har diabetes. Dock är studierna som visar på skillnader alldeles för få, det behövs fler och större undersökningar inom detta område. Denna litteratur översikt visar också att det även kan vara så att inte alla etniciteter gynnas av dagens behandlingar som finns mot hjärt- och kärlsjukdomar som t ex Betablockerare. Slutsatsen i denna studie är att mer forskning inom ämnet behövs samt fler övergripande studier gällande folkhälsan i Mellanöstern.
Wang, Xin. "Physical activity and cardiovascular disease mortality, morbidity and all-cause mortality in Chinese elderly people." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508257.
Повний текст джерелаHolmlund, Anders. "Oral health and cardiovascular disease." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8708.
Повний текст джерелаAjwani, Shilpi. "Periodontal disease in an aged population, and its role in cardiovascular mortality." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/hamma/vk/ajwani/.
Повний текст джерелаWang, Xin, and 王昕. "Physical activity and cardiovascular disease mortality, morbidity and all-cause mortality in Chinese elderly people." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508257.
Повний текст джерелаMolloy, Eamonn S. "Cardiovascular Outcomes and In-Hospital Mortality in Giant Cell Arteritis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1212093974.
Повний текст джерелаDjietror, Godwin A. Elliott Susan J. "Towards an understanding of geographic variation in cardiovascular disease mortality and morbidity in Ontario, 1986--1994 /." *McMaster only, 2003.
Знайти повний текст джерелаGuasch, Ferré Marta. "Components of the mediterranean diet on cardiovascular disease and mortality in a population at high cardiovascular risk." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/284450.
Повний текст джерелаLas enfermedades cardiovasculares (CV) son una de las primeras causas de morbi-mortalidad en todo el mundo. Estas enfermedades, en gran medida, se podrían prevenir. La Dieta Mediterránea ha sido reconocida como uno de los patrones alimentarios más saludables. Hasta el momento, existe una fuerte evidencia científica que demuestra los beneficios de la dieta Mediterránea en la prevención y el tratamiento de la enfermedad cardiovascular. Esta tesis ha sido realizada en el contexto del estudio PREDIMED, un estudio clínico paralelo, multicéntrico y aleatorizado que evalúa el efecto de la dieta mediterránea, en comparación a una dieta baja en grasa, en la prevención primaria de la enfermedad cardiovascular. El objetivo fue determinar el efecto de los frutos secos, aceite de oliva y magnesio en el riesgo cardiovascular, mortalidad por causa específica y mortalidad por todas las causas en una población Mediterráneo con alto riesgo cardiovascular. Todos los alimentos evaluados son componentes claves del patrón de dieta Mediterránea y son consumidos en altas cantidades en nuestra población. Los resultados del presente trabajo demostraron que consumir frutos secos con más frecuencia estaba inversamente relacionado con la mortalidad cardiovascular, mortalidad por cáncer y mortalidad total tras seguir a los participantes durante una media de 4.8 años. Observamos también que el aceite de oliva, concretamente la variedad extra virgen, se asociaba a un riesgo reducido de enfermedad cardiovascular y mortalidad cardiovascular después de 4.8 años de media de seguimiento. También observamos que el magnesio dietético se asociaba inversamente a la muerte cardiovascular, por cáncer y mortalidad total. En conclusión, los resultados corroboran los efectos beneficiosos de los componentes de la dieta Mediterránea en la prevención de enfermedad cardiovascular y muerte.
Cardiovascular disease (CVD) is one of the main causes of disability and death worldwide. Importantly, in a large extent, CVD are preventable. The Mediterranean Diet (MedDiet) is recognized as one of the healthier dietary patterns. To date, strong evidence exists supporting the benefits of the MedDiet for the prevention and management of CVD. This thesis has been conducted in the framework of the PREDIMED Study, a parallel-group, multicenter randomized nutrition trial evaluating the efficacy of a MedDiet compared to a low-fat control diet on the primary prevention of CVD. We aimed to asses the associations between nuts, olive oil and its varieties, and magnesium on the risk of CVD, cause-specific and all-cause mortality on an elderly Mediterranean population at high cardiovascular risk. All of these foods are key components of the MedDiet pattern and are highly consumed in our population. The results of the present work demonstrate that the frequency of nut consumption was inversely related to cardiovascular, cancer and total mortality after 4.8 years of follow-up. We found that olive oil consumption, specifically the extra-virgin variety, was associated with reduced risk of cardiovascular disease and cardiovascular mortality after 4.8 years of follow-up. We have also observed that dietary magnesium intake was inversely associated with cardiovascular, cancer and total mortality risk after 4.8 years of follow-up. In conclusion, the findings of this thesis support the healthy benefits of the components of a MedDiet on the primary prevention of cardiovascular disease and mortality.
Soveri, Inga. "Renal Dysfunction and Cardiovascular Disease." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6941.
Повний текст джерелаGunnarsson, Linus. "Exposure to respirable dust and cardiovascular disease mortality among Swedish iron foundry workers." Thesis, Örebro universitet, Institutionen för läkarutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-43015.
Повний текст джерелаHögström, Gabriel. "Cardiovascular disease and all-cause mortality : influence of fitness, fatness and genetic factors." Doctoral thesis, Umeå universitet, Geriatrik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130312.
Повний текст джерелаLuke, Baw D. "Educational attainment and cardiovascular disease related mortality a retrospective cohort evaluation of Chinese elderly population in Hong Kong /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41711373.
Повний текст джерелаOgale, Sarika S. "Mortality and cardiovascular outcomes associated with medications used in the treatment of chronic obstructive pulmonary disease /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7959.
Повний текст джерелаToss, Fredrik. "Body fat distribution, inflammation and cardiovascular disease." Doctoral thesis, Umeå universitet, Institutionen för samhällsmedicin och rehabilitering, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49833.
Повний текст джерела陸坡 and Baw D. Luke. "Educational attainment and cardiovascular disease related mortality: a retrospective cohort evaluation ofChinese elderly population in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41711373.
Повний текст джерелаGenkinger, Jeanine Marie. "Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause cancer and cardiovascular disease mortality." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080663.
Повний текст джерелаJobs, Elisabeth. "Cathepsin S as a Biomarker of Low-grade Inflammation, Insulin Resistance, and Cardiometabolic Disease Risk." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234027.
Повний текст джерелаSödergren, Anna. "Epidemiological and pathogenic aspects on cardiovascular disease in rheumatoid arthritis." Doctoral thesis, Umeå universitet, Reumatologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1906.
Повний текст джерелаWållberg, Jonsson Solveig. "On inflammation and cardiovascular disease in patients with rheumatoid arthritis." Doctoral thesis, Umeå universitet, Reumatologi, 1996. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141304.
Повний текст джерелаs. 1-54: sammanfattning, s. 55-133: 6 uppsatser
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McCarron, Peter. "Adolescent and early adult factors and cardiovascular disease mortality : results from the Glasgow University alumni cohort." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288294.
Повний текст джерелаCalvin, Catherine Mary. "Exploring longitudinal pathways from intelligence to morbidity and mortality risk." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9982.
Повний текст джерелаCampos, Alessandra Arantes da Silva. "MORTALIDADE POR DOENÇAS CARDIOVASCULARES EM MULHERES EM IDADE FÉRTIL NO ESTADO DE GOIÁS (2000-2014)." Pontifícia Universidade Católica de Goiás, 2017. http://tede2.pucgoias.edu.br:8080/handle/tede/3736.
Повний текст джерелаMade available in DSpace on 2017-08-18T14:18:52Z (GMT). No. of bitstreams: 1 ALESSANDRA ARANTES DA SILVA CAMPOS.pdf: 415649 bytes, checksum: ab4b35efcca04c630226e9335856e2fe (MD5) Previous issue date: 2017-06-26
Cardiovascular diseases are among the leading causes of death in the world and in Brazil. Women of childbearing age have been affected by these events in increasingly significant numbers, since it modifies the expected pattern of deaths in this age group. This dissertation aimed to outline the epidemiological profile of cardiovascular disease mortality in women of childbearing age, in the state of Goiás, from 2000 to 2014. It is a retrospective study with a quantitative approach. The data corresponding to the deaths of women of childbearing age, from 10 to 49 years, for cardiovascular diseases (Chapter IX of ICD-10), in the state of Goiás, were digitally accessed at the Mortality Information Service (SIM) in the period of 2000 To 2014. Cardiovascular diseases ranked third in the number of deaths in the study group. The most prevalent diseases that led to women of childbearing age were, respectively, cerebrovascular diseases, ischemic heart diseases and other forms of heart disease. Mortality declined in the group of women between the ages of 20 and 49, with a more pronounced decline in the age group of 40 to 49 years. In relation to marital status, there was a decrease in the number of deaths of married and widowed women and an increase among women in a stable union. In terms of schooling, there was a decrease in the number of deaths among women with uninformed or ignored education and without any education, whereas among women with four years or more of education there was an increase in the number of deaths. There was an increase in the number of deaths among women of brown color and fall among white women. In the majority of cases, women died, especially in the hospital environment, with deaths occurring at home in the second place. It is concluded that, over the years, women of childbearing age have presented better responses regarding the modification of risk factors for cardiovascular diseases, as well as adherence to guiding principles for the reduction of these risk factors. Although health and education policies have followed this trend, they still lack epidemiological evidence for their better targeting and implementation.
As doenças cardiovasculares estão entre as principais causas de óbito no mundo e no Brasil. As mulheres em idade fértil têm sido acometidas por esses eventos em números cada vez mais expressivos, dado que modifica o padrão esperado dos óbitos nesta faixa etária. A presente dissertação teve por objetivo delinear o perfil epidemiológico da mortalidade por doenças cardiovasculares em mulheres em idade fértil, no estado de Goiás, no período de 2000 a 2014. Trata-se de um estudo retrospectivo com abordagem quantitativa. Foram acessados digitalmente no Serviço de Informação de Mortalidade (SIM) os dados correspondentes às mortes de mulheres em idade fértil, entre 10 e 49 anos, por doenças cardiovasculares (Capítulo IX do CID-10), no estado de Goiás, no período de 2000 a 2014. As doenças cardiovasculares ocuparam a terceira colocação no número de óbitos no grupo estudado. As doenças mais prevalentes que levaram as mulheres em idade fértil a óbito foram, respectivamente, as doenças cerebrovasculares, as doenças isquêmicas do coração e outras formas de doenças do coração. Houve queda da mortalidade no grupo de mulheres entre 20 e 49 anos, com declínio mais acentuado na faixa etária de 40 a 49 anos. Em relação ao estado civil, observou-se queda no número de óbitos de mulheres casadas e viúvas e aumento entre mulheres em união estável. Em se tratando de escolaridade, houve diminuição do número de óbitos entre as mulheres com instrução não informada ou ignorada e sem nenhuma instrução, enquanto entre as mulheres com quatro anos ou mais de instrução registrou-se aumento do número de óbitos. Foram identificados aumento do número de óbitos entre mulheres de cor parda e queda entre mulheres brancas. Em sua maioria, as mulheres vieram a óbito especialmente em ambiente hospitalar, ficando em segundo lugar os óbitos em seus domicílios. Conclui-se que, ao longo dos anos, as mulheres em idade fértil têm apresentado melhores respostas quanto à modificação dos fatores de risco das doenças cardiovasculares, assim como em relação à adesão aos princípios norteadores para a diminuição destes fatores de risco. Embora as políticas de saúde e educação venham acompanhando tal tendência, ainda carecem de evidências epidemiológicas para seu melhor direcionamento e implementação.
Brückmann, Burkhard [Verfasser], and Stefan [Akademischer Betreuer] Blankenberg. "Predictive value of testosterone as marker for cardiovascular disease and overall mortality / Burkhard Brückmann ; Betreuer: Stefan Blankenberg." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1201821274/34.
Повний текст джерелаBrückmann, Burkhard Verfasser], and Stefan [Akademischer Betreuer] [Blankenberg. "Predictive value of testosterone as marker for cardiovascular disease and overall mortality / Burkhard Brückmann ; Betreuer: Stefan Blankenberg." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:18-101651.
Повний текст джерелаStrong, Victoria J. "Getting to the heart of the matter : an investigation into captive great ape mortality and cardiovascular disease." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47906/.
Повний текст джерелаLane, Deirdre Anne. "The effects of depression and anxiety on mortality, CHD incidence, and quality-of-life after myocardial infarction." Thesis, University of Birmingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368439.
Повний текст джерелаWageck, Aline André Rodrigues. "Risco cardiovascular em pacientes com transtorno de humor bipolar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164356.
Повний текст джерелаBipolar disorder (BD) is a disabling condition characterized by the presence of mood episodes associated with changes in cognition and behavior. Individuals diagnosed with BD are particularly prone to multiple metabolic conditions. In a portion of the patients affected by the disease the neuroprogression is observed, with alterations in the field of neuroimaging and of biomarkers - inflammatory cytokines, oxidative stress and neurotrophins. These factors also seem to be related to the increased cardiovascular risk (CVR) observed in this population, since cardiovascular disease (CVD) is the main cause of death in patients with BD. Even knowing this statistic, there is a paucity of scientific literature addressing cardiovascular evaluation in bipolar patients. Thus, the present thesis aims to improve the understanding of the association between neuroprogression and cardiovascular disease. To this objective, we initially conducted a literature review encompassing variables associated with staging and neuroprogression, especially aspects that refer to biomarkers, neuroimaging, cognition, functionality and response to treatment. Afterwards, a clinical study was performed to evaluate the prevalence of coronary atherosclerotic disease through the use of coronary calcium score (CCS) in outpatient bipolar type 1 patients. The patients included were diagnosed as BD type 1, all of them euthymic and signed the consent form. Calcium scores were acquired using an Aquilion 64 CXL scanner (Toshiba Medical Systems) and quantification performed using the Agatston method. In our study, patients with CCS positive were older (mean 55.2 years; p = 0.001) and had a higher mean of previous psychiatric hospitalizations (mean 4.7, p = 0.04) when compared to the CCS negative group, and there was also a positive association between CCS and number of previous psychiatric hospitalizations among the entire study sample (p<0.001). Our results suggest the association between age and higher coronary scores, as well as the relationship between coronary calcium and the number of previous psychiatric hospitalizations. It is possible that this finding is related to the fact that patients in more advanced stages of the disease have a higher inflammatory load that, together with the risk factors for CVD, would justify the increase of CVR, suggesting a possible link between neuroprogression in BD and accelerated coronary atherosclerosis.
Fiedorowicz, Jess G. "Course of illness and the development of vascular disease in individuals with bipolar disorder." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2699.
Повний текст джерелаTamakoshi, Akiko, Yutaka Inaba, Yasuhiko Wada, Takaaki Kondo, Akio Koizumi, Shogo Kikuchi, Akio Yamamoto, et al. "Fruit, vegetable and bean intake and mortality from cardiovascular disease among Japanese men and women : the JACC Study." Cambridge University Press, 2009. http://hdl.handle.net/2237/14317.
Повний текст джерелаMcSwiggan, Stephen John. "Cardiovascular events and mortality in systemic sclerosis : a study of the effect of Iloprost on these and on disease progression : the SSTEP Study (Systemic Sclerosis Trial of Events and Progression)." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/163dc6e5-b5dd-4945-9756-8dae629cff48.
Повний текст джерелаSievers, Caroline, Jens Klotsche, Lars Pieper, Harald J. Schneider, Winfried März, Hans-Ulrich Wittchen, Günter K. Stalla, and Christos Mantzoros. "Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100966.
Повний текст джерелаGaliyeva, Dinara. "Cardiovascular risk factor prevalence, mortality and cardiovascular disease incidence in patients who initiated renal replacement therapy in childhood : systematic review and analyses of two renal registries." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28837.
Повний текст джерелаBrowne, Stephen. "A study of the association of cold weather and all-cause and cause-specific mortality on the island of Ireland between 1984 and 2007." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11559.
Повний текст джерелаDerry, Christopher William. "The relationship between the hardness of potable water and cardiovascular and ischaemic heart disease mortality in South African urban areas." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/25808.
Повний текст джерелаCarstens, Nadia. "Renin-angiotensin-aldosterone system genes and the complex hypertrophic phenotype of hypertrophic cardiomyopathy." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71949.
Повний текст джерелаENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a strong independent predictor of cardiovascular morbidity and mortality, while its regression is associated with an improved clinical prognosis. It is, therefore, vital to elucidate and fully comprehend the mechanisms that contribute to LVH development and to identify markers that indicate a strong predisposition to the development of severe cardiac hypertrophy, before its occurrence. Hypertrophic cardiomyopathy (HCM) serves as a model to investigate LVH development. This primary cardiac disease is characterised by LVH in the absence of increased external loading conditions and is caused by defective sarcomeric proteins, as a result of mutations within the genes encoding these proteins. However, the hypertrophic phenotype of HCM is largely complex, as we see strong variability in the extent and distribution of LVH in HCM, even in individuals with the same disease-causing mutation from the same family; this points toward the involvement of additional genetic and environmental modifiers. Components of the renin-angiotensin-aldosterone system (RAAS) influence LVH indirectly, through their key role in blood pressure regulation, but also directly, due to the direct cellular hypertrophic effects of some RAAS components. Previous genetic association studies aimed at investigating the contribution of RAAS variants to LVH were largely centred on a subset of polymorphisms within the genes encoding the angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor genes, while the renin section and RAAS components downstream from ACE remained largely neglected. In addition, most previous studies have reported relatively small individual effects for a small subset of RAAS variants on LVH. In the present study we, therefore, employ a family-based genetic association analysis approach to investigate the contribution of the entire RAAS to this complex hypertrophic phenotype by exploring both the individual as well as the compound effects of 84 variants within 22 RAAS genes, in a cohort of 388 individuals from 27 HCM families, in which either of three HCM-founder mutations segregate. During the course of this explorative study, we identified a number of RAAS variants that had significant effects on hypertrophy in HCM, whether alone or within the context of a multi-variant haplotype. Through single variant association analyses, we identified variants within the genes encoding angiotensinogen, renin-binding protein, the mannose-6-phosphate receptor, ACE, ACE2, angiotensin receptors 1 and 2, the mineralocorticoid receptor, as well as the epithelial sodium channel and the Na+/K+-ATPase β-subunits, that contribute to hypertrophy in HCM. Using haplotype-based association analyses, we were able to identify haplotypes within the genes encoding for renin, the mannose-6-phosphate receptor, angiotensin receptor 1, the mineralocorticoid receptor, epithelial sodium channel and Na+/K+-ATPase α- and β subunits, as well as the CYP11B1/B2 locus, that contribute significantly to LVH. In addition, we found that some RAAS variants and haplotypes had statistically significantly different effects in the three HCM founder mutation groups. Finally, we used stepwise selection to identify a set of nine risk-alleles that together predicted a 127.80 g increase in left ventricular mass, as well as a 13.97 mm increase in maximum interventricular septal thickness and a 14.67 mm increase in maximum left ventricular wall thickness in the present cohort. In contrast, we show that a set of previously identified “pro-LVH” polymorphisms rather poorly predicted LVH in the present South African cohort. This is the first RAAS investigation, to our knowledge, to provide clear quantitative effects for a subset of RAAS variants indicative of a risk for LVH development that are representative of the entire pathway. Our findings suggest that the eventual hypertrophic phenotype of HCM is modulated by the compound effect of a number of RAAS modifier loci, where each polymorphism makes a modest contribution towards the eventual phenotype. Research such as that presented here provides a basis on which future studies can build improved risk profiles for LVH development within the context of HCM, and ultimately in all patients with a risk of cardiac hypertrophy.
AFRIKAANSE OPSOMMING: Linker ventrikulêre hipertrofie (LVH) is 'n sterk onafhanklike voorspeller van kardiovaskulêre morbiditeit en mortaliteit, terwyl LVH regressie verband hou met ‘n verbeterde kliniese voorspelling. Dit is dus noodsaaklik om die meganismes wat bydra to LVH ontwikkeling ten volle te verstaan en merkers wat 'n sterk geneigdheid tot die ontwikkeling van ernstige kardiale hipertrofie te identifiseer, voordat dit voorkom. Hipertrofiese kardiomiopatie (HKM) dien as 'n model om LVH ontwikkeling te ondersoek. Hierdie primêre hartsiekte word gekenmerk deur LVH en word meestal veroorsaak deur foutiewe sarkomeer proteïene as gevolg van mutasies binne die gene wat kodeer vir hierdie proteïene. Die hipertrofiese fenotipe van HKM is egter grootliks kompleks; ons sien, by voorbeeld, sterk veranderlikheid in die omvang en die verspreiding van LVH in HKM, selfs in individue met dieselfde siekte-veroorsakende mutasie binne dieselfde gesin, wat dui op die betrokkenheid van addisionele genetiese en omgewing modifiseerders. Komponente van die renien-angiotensien-aldosteroon sisteem (RAAS) beïnvloed LVH indirek, deur middel van hul belangrike rol in bloeddruk regulasie, maar ook direk, as gevolg van die direkte sellulêre hipertrofiese gevolge van sommige RAAS komponente. Vorige genetiese assosiasie studies wat daarop gemik was om die bydrae van RAAS variante LVH te ondersoek, was hoofsaaklik gesentreer op 'n groepie polimorfismes binne die gene wat kodeer vir die “angiotensin converting enzyme” (ACE) en angiotensien II tipe 1-reseptor gene, terwyl die renien gedeelte en RAAS komponente stroomaf van ACE meestal nie ondersoek was nie. Daarbenewens het die meeste vorige studies relatief klein individuele gevolge gerapporteer vir 'n klein groepie RAAS variante op LVH. In die huidige studie het ons dus 'n familie-gebaseerde genetiese assosiasie-analise benadering gebruik om die bydrae van die hele RAAS tot hierdie komplekse hipertrofiese fenotipe te ondersoek deur 'n studie van die individuele-, sowel as die saamgestelde effekte van 84 variante binne 22 RAAS gene, in 'n groep van 388 individue vanaf 27 HKM families, waarin een van drie HCM-stigter mutasies seggregeer. Gedurende die loop van hierdie studie het ons 'n aantal RAAS variante wat ‘n beduidende uitwerking op HKM hipertrofie geïdentifiseer, hetsy alleen of binne die konteks van' n multi-variant haplotipe. Deur middel van enkele variant assosiasie toetsing het ons variante geïdentifiseer binne die gene wat kodeer vir angiotensinogen, renien-bindende proteïen, die mannose-6-fosfaat reseptor, ACE, ACE2, angiotensien reseptore 1 en 2, die mineralokortikoïd reseptor, sowel as die epiteel natrium kanaal en Na+/ K+-ATPase β-subeenhede, wat bydra tot HKM hipertrofie. Deur die gebruik van haplotipe-gebaseerde assosiasie ontleding was ons in staat om haplotipes te identifiseer binne die gene wat kodeer vir renien, die mannose-6-fosfaat reseptor angiotensien reseptor 1, die mineralokortikoïd reseptor, epiteel natrium kanaal en die Na+/ K+-ATPase α-en β subeenhede, sowel as die CYP11B1/B2 lokus, wat aansienlik bydra tot LVH. Verder het ons bevind dat sommige RAAS variante en haplotipes statisties beduidende verskillende effekte gehad het in die drie HKM stigter mutasie groepe. Laastens, het ons stapsgewyse seleksie gebruik om 'n stel van nege risiko-allele wat saam' n toename van 127.80 g in linker ventrikulêre massa, sowel as 'n 13.97 mm toename in maksimum ventrikulêre septale dikte, en' n 14.67 mm verhoging in maksimum linker ventrikulêre wanddikte voorspel, te identifiseer in die huidige kohort. In teenstelling hiermee wys ons dat 'n stel van voorheen geïdentifiseerde "pro-LVH" polimorfismes swakker gevaar het as LVH-voorspellers in die huidige Suid-Afrikaanse kohort. Hierdie is die eerste RAAS ondersoek, tot ons kennis, wat ‘n duidelike kwantitatiewe gevolge vir 'n stel RAAS variante wat ‘n verhoogde risiko tot LVH ontwikkeling aandui, wat verteenwoordigend is van die hele RAAS. Ons bevindinge dui daarop dat die uiteindelike hipertrofiese fenotipe van HKM gemoduleer word deur die saamgestelde effek van 'n aantal RAAS wysiger loki, waar elke polimorfisme ' n beskeie bydrae maak tot die uiteindelike fenotipe. Navorsing soos dié wat hier aangebied word dien as 'n basis waarop toekomstige studies kan bou vir ‘n verbeterde risiko-profiel vir LVH ontwikkeling binne die konteks van die HKM, en uiteindelik in alle pasiënte met' n verhoogde risiko vir kardiale hipertrofie.
Sievers, Caroline, Jens Klotsche, Lars Pieper, Harald J. Schneider, Winfried März, Hans-Ulrich Wittchen, Günter K. Stalla, and Christos Mantzoros. "Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients." BioScientifica, 2010. https://tud.qucosa.de/id/qucosa%3A26327.
Повний текст джерелаSmolina, Ekaterina. "Examination of the epidemiology of acute myocardial infarction in England using linked hospital and mortality data." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:791b416e-140e-4ced-9703-76d76895e9f8.
Повний текст джерелаWeller, Iris M. R. "The effects of measurement error on the relation between physical activity and cardiovascular disease mortality in the Canada Fitness Survey cohort." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ41337.pdf.
Повний текст джерелаMoe, Børge. "Diabetes and Leisure Time Physical Activity in Relation to Cardiovascular Disease Risk and Mortality : Prospective data from the HUNT Study, Norway." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for samfunnsmedisin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-27183.
Повний текст джерелаDenne avhandlingen består av tre prospektive studier som undersøker hvorvidt fysisk aktivitet kan kompensere for den uheldige sammenhengen mellom diabetes og risiko for kardiovaskulær død og risiko for hjerteinfarkt. Vi har benyttet data fra Helseundersøkelsen i Nord-Trøndelag koblet til Dødsårsaksregisteret, samt informasjon om sykehusinnleggelser grunnet hjerteinfarkt ved de to sykehusene i Nord-Trøndelag. Diabetes var assosiert med nesten tre ganger så høy risiko for å dø av kardiovaskulær sykdom hos de fysisk inaktive. Personer med diabetes som rapporterte ≥ 3 timer med lett fysisk aktivitet per uke, hadde tilsvarende risiko som inaktive personer uten diabetes. Videre fant vi at den gunstige effekten av fysisk aktivitet var størst for de med alvorligst grad av diabetes, målt som medikamentell behandling. Vi fant også en økt risiko for hjerteinfarkt blant personer med diabetes, og at denne forhøyete risikoen ble kansellert blant de som rapporterte et høyt fysisk aktivitetsnivå. En normal kroppsvekt var også assosiert med lavere risiko for hjerteinfarkt, særlig i kombinasjon med fysisk aktivitet. Våre resultater tyder på at den gunstige effekten av fysisk aktivitet er innen rekkevidde for de fleste med diabetes og i enda større grad bør vektlegges som et ledd i behandlingen av personer med diabetes, i tillegg til medisinering.
Jimenez, Zaida Noemy Cabrera. "Índice de pressão tornozelo-braquial em pacientes renais crônicos incidentes em hemodiálise." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-01032012-100808/.
Повний текст джерелаCardiovascular disease is an important cause of death in patients on dialysis. Peripheral arterial disease (PAD) is a prognostic factor for cardiovascular disease. Ankle-brachial index (ABI) is a non-invasive method used for the diagnosis of PAD. The difference between ABI pre and post dialysis was not yet formally tested, and it was one objective of this study. In addition, we evaluate the ABI in predict mortality in incident patients on hemodialysis. ABI was assessed by automated oscillometric device in incident patients on hemodialysis. This study was designed to assess the applicability of ABI determination with the employment of two automated oscillometric blood pressure devices simultaneously (Omron Corp 705 CP Corp, Tokyo, Japan), comparing pre and post dialysis as well right and left side. The measurements were done by using two oscillometric devices simultaneously to measure blood pressure in upper and lower extremities. 123 patients (85 men and 35 women), age 53±19 years were enrolled. Blood pressure measurements on the right side and on the left side presented similar means (p=0,565), as well in the consecutive sessions, times 1, 2 and 3, (coefficient of variation lower than 5). We found no difference in ABI pre and post dialysis, either on the right or left side, as well in times 1, 2 and 3. In patients with history of PAD, the ABI pre vs. post dialysis was of borderline significance on the right side (p=0.088). During the follow-up period, 31 patients died. These patients were older and presented higher calcium level. Diabetes, hypertension and any other cardiovascular risk factor were not associated with mortality. Patients with either low ABI or high ABI (<0.9 and >1.3, respectively) presented higher mortality than patients with normal ABI (0.9-1.3). We concluded that ABI measured pre and post dialysis offered low variability. The ABI in patients with history of PAD should be evaluating with caution. The current method applied in this study can predict mortality among incident patients on hemodialysis
Önder, Stefan. "Adrenal incidentaloma : – A retrospective study of cardiovascular mortality and morbidity in patients with hypercortisolemia defined by the European Society of Endocrinology guidelines." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77252.
Повний текст джерелаNilsson, Lena Maria. "Sami lifestyle and health : epidemiological studies from northern Sweden." Doctoral thesis, Umeå universitet, Näringsforskning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51825.
Повний текст джерелаSyftet med denna avhandling var att beskriva livsstil och kostvanor hos samer. Det var också att undersöka hur en ”traditionell samisk” livsstil påverkar risken att insjukna av eller dö i cancer och hjärt-/kärlsjukdom i en norrländsk normalbefolkning. En majorietsbefolkning har alltså undersökts ur ett minoritetsperspektiv. Avhandlingen belyser framför allt kostvanor, fördelning av de näringsämnen som innehåller energi (kolhydrat, protein, fett) och konsumtion av kok- och bryggkaffe. Bakgrunden till undersökningarna var att samerna, till skillnad från de flesta andra urfolk i världen, kan förvänta sig ett lika långt liv som majoritetsbefolkningen. När det gäller hjärtkärlsjukdom finns inga stora etniska skillnader, men samiska män, särskilt renskötande, har lägre risk att drabbas av cancer än icke-samer. Det finns ingen entydig förklaring till samernas relativt goda hälsa, men det kan finnas ett samband med kostvanor och livsstil. Delstudie I var en intervjustudie med äldre samer och fungerade som bakgrund för de andra delstudierna. Tjugo äldre samer intervjuades om sina föräldrars livsstil och kostvanor för 50-70 år sedan. Dessutom analyserades kostdata från 81 renskötande och 226 icke-renskötande samer och 1842 matchade icke-samer för att se vilka skillnader som fanns mellan grupperna. Intervjuerna visade överraskande att fet fisk kan ha varit viktigare än renkött för samerna i södra Lappland under 1930-1950-talen. Fet fisk äts fortfarande i högre utsträckning av renskötande samer än av andra samer och icke-samer. Saker som har hög kulturell betydelse (i detta fall renkött) behöver alltså inte alltid ha lika stor betydelse ur ett objektivt, vetenskapligt perspektiv. Andra typiska särdrag hos den samiska kosten var en hög andel av fett, blod och kokkaffe och en låg andel av bröd, fibrer och odlade grönsaker. Det dagliga livet hos samerna på 1930-1950-talen präglades också mycket mer av fysisk aktivitet än vad det gör idag. De samiska männen arbetade oftast långt hemifrån, medan kvinnorna hade ansvaret hemmavid för fiske, jordbruk och trädgårdsskötsel (som introducerades under 1930-1950-talen). Kvinnorna tog även hand om hushållsarbetet och barnen. Delstudierna II-V handlade om olika aspekter av samisk kost i relation till dödlighet och sjuklighet. Till dessa användes huvudsakligen data från Västerbottens hälsoundersökningar, men i delstudie V även från MONICA-projektet, som är en del av ett multinationell forskningsprojekt om hjärt-/kärlsjukdom. Totalt ingick på så sätt data från mer än 80 000 unika individer från en allmän, till största delen icke-samisk, normalbefolkning. Delstudie II byggde på en modell liknande den som använts för att undersöka hälsoeffekter av så kallad Medelhavsdiet. En poängskala från 0-8 poäng, en så kallad ”Sami diet score”, skapades för att spegla likheter med ”traditionell samisk” kost. Den hälft av deltagarna som åt mest rött kött, fet fisk, fett, bär respektive kokkaffe, fick 1 poäng var, sammanlagt maximalt 5 poäng. Den hälft av deltagarna som åt minst grönsaker, bröd respektive fibrer fick också 1 poäng var, sammanlagt maximalt 3 poäng. Stora likheter med en ”traditionell samisk” kost, det vill säga höga ”Sami diet score” poäng, var förknippade med en svagt ökad dödlighet, särskilt hos männen. Det verkar därför osannolikt att den samiska kosten i sig förklarar den relativt goda hälsan hos samer. Denna fråga är dock mycket svår att undersöka, eftersom kostvanorna kan ha skiljt sig mellan olika samegrupper och över tid. Dessutom äter dagens västerbottningar mycket mindre av vissa livsmedel, jämfört med vad samerna gjorde förr i tiden. Det gäller till exempel fet fisk och bär. För sådana livsmedel kan det därför vara extra svårt att påvisa samband med dödlighet. Syftet med kostenkäten i Västerbottens hälsoundersökningar är inte heller att spegla en ”traditionell samisk” kost. Det finns till exempel inga frågor om renkött och vilt, utan sådant kött räknas som en del av övrigt rött kött. Det här är första gången som någon undersökt betydelsen av ett ”traditionellt samiskt” kostmönster för hälsan på detta sätt. Fler liknande undersökningar i material med mer detaljerade frågor, som bättre fångar en samisk kost, är önskvärda. Lågkolhydratdieter, som har vissa likheter med den ”traditionella samiska” kosten, är både populära och kontroversiella. Eventuella långtidseffekter för hälsan är till stor del okända. I delstudie III speglades förhållandet mellan kolhydrater och protein i kosten med hjälp av så kallade LCHP (låg-kolhydrat, hög-protein) poäng. Högsta LCHP poäng fick de deltagare som åt minst kolhydrater och mest protein. Höga LCHP poäng påverkade inte risken att dö, eller att dö i cancer eller hjärt-/kärlsjukdom, efter att statistisk hänsyn tagits till intaget av mättat fett och de vanligaste riskfaktorerna. LCHP score användes i denna studie, istället för exempelvis en LCHF (low carbohydrate, high fat) variant. På så sätt kunde betydelsen av total fettmängd och av mättat fett också vägas in i analyserna. Dessutom innehåller kolhydrater och protein samma mängd energi per gram, vilket gör det lättare att byta ut dem mot varandra i en poängskala. Fett innehåller nästan dubbelt så mycket energi per gram som proteiner och kolhydrater. Inte bara olika sorters fett, utan även olika sorters protein och kolhydrater, kan spela roll för hälsan. Det är därför mycket svårt att skilja ut effekterna av mängd och kvalitet av kolhydrater, protein och fett i kosten. I delstudierna IV och V undersöktes risken att bli sjuk i cancer eller få en akut hjärtinfarkt hos västerbottningar som dricker mer respektive mindre kok- och bryggkaffe. De som drack mycket kaffe hade varken ökad generell cancerrisk, eller ökad risk för prostata- eller tjocktarmscancer. Kvinnor som drack kokkaffe ≥ 4 ggr/dag hade minskad risk för bröstcancer jämfört med kvinnor som drack <1 gång/dag. Både totalt kaffeintag och intag av bryggkaffe var kopplade till ökad risk för bröstcancer hos yngre kvinnor och minskad risk hos äldre. Män som drack mycket kokkaffe hade ökad risk för cancer i luftvägarna. Dessa resultat visar att de som dricker olika sorters kaffe kan ha olika stor risk att drabbas av olika sorters cancer. I tidigare studier har inga starka samband hittats mellan kaffedrickande och cancer. Denna studie var den första att undersöka hur cancerriskerna ser ut hos människor som dricker olika sorters kaffe. När det gäller hjärtinfarkt, hade män som drack mycket bryggkaffe ökad risk, medan inga entydiga resultat kunde visas bland män som drack mycket kokkaffe. Tidigare studier har visat motstridiga resultat när det gäller kaffe och hjärt-/kärlsjukdom, även om kaffekonsumtion är vedertaget förknippat med en del faktorer som kan öka risken att drabbas av hjärtinfarkt, till exempel ökade halter av blodfetter. Betydelsen av kokkaffe har aldrig undersökts tidigare i en studie där uppgifter om kaffedrickande samlats in i förväg. Delstudierna II-V är alla så kallade observationsstudier. I sådana studier följer deltagarna ingen bestämd forskningsplan, utan lever sina normala liv och jämförs sedan med varandra. I observationsstudier är det mycket svårt att ta hänsyn till alla möjliga störande faktorer som kan finnas i omgivningen. Därför är det i princip omöjligt att bevisa direkta samband mellan orsak och verkan i en observationsstudie. Delstudierna II-V hade emellertid den starkaste design som en observationsstudie kan ha. De byggde på en representativ normalbefolkning (= en befolkningsbaserad kohort), där data samlats in från ett stort antal personer (> 80 000 unika individer) medan de ännu var friska (= en prospektiv kohort). Resultaten av enstaka observationsstudier har störst betydelse som underlag för att planera nya liknande, eller andra typer av mer riktade undersökningar. De är med andra ord hypotesgrundande. Om däremot flera observationsstudier visar på liknande resultat brukar man utgå från att resultaten är sanna, eller åtminstone sannolika.
(Nordsamiska) Guorahallama ulbmil lea muitalit sámi biepmu ja eallinvuogi birra ja iskat got árbevirolaš sámi borranvierut, makrobiebmama juogustus ja gáffegolaheapmi váikkuhit jámolašvuođa ja riskka oažžut borasdávdda dehe váibmo-/ suotnadávdda dábálaš davvi-ruoŧŧelaš ássiid luhtte. Guoktelogi sámi vuorrasa ledje jearahallon daid vánhemiid eallinvuogi ja borramuša birra 50-70 jagi áigi (Oassedutkan 1). Dasa lassin 397 sámi ja 1842 ruoŧŧelačča biebmandata guorahallojuvvo eahpe-paramehtarlaš iskamiid ja partialalaš unnimus kvadráhta metoda (PLS) mielde. Dát golbma čuovvovaš oassedutkama, gait kohortdutkamat, isket jápminsiva dehe borasdávdabuohccivuođa oaseváldiid luhtte Västerbottenis dearvas-vuohŧaiskkademiid hárrái (64 603-77 319 iskama) ja riskkaluoitimat leat rehkenaston Cox regrešuvnna mielde. Oassedutkamis 2 árbevirolaš sámi biebman lea speadjalaston čuokkesskála vuostá 0 rájes gitta 8 čuoggá. Dát bealli oaseváldiin geat leat eanemus rukses bierggu, buoiddes guoli, buoiddi, murjiid ja vuoššangáfe borran, lea ožžon 1 čuoggá juohke áidna biebmanelemeanta ovddas, oktiibuot eanemus 5 čuoggá. Vel 3 čuoggá dát bealli oaseváldiin lea ožžon geat lea unnimus šattuid, láibbi ja fiberiid borran, eanemus oktiibuot 3 čuoggá. Oassedutkamis 3 speadjalastá oktavuođa kolhydráhtaid ja proteiinnaid gaskkas biebmamis LCHP (vuolit-kolhydráhta, alit-proteiidna) čuoggáid bokte. Alimus LHCP čuoggát (=20) dát oasseváldit leat ožžon geat leat borran unnimus kolhydráhtaid ja eanemus proteiinnaid ja vuolimus čuoggát (=2) dát oasseváldit leat ožžon geat leat borran eanemus kolhydráhtaid ja unnimus proteiinnaid. Oassedutkamis 4 riska borasdávdabuohccivuođa ektui guorahallojuvvo brygg- ja vuoššangáffejuhkkiid luhtte. Oassedutkan 5 lei goallostuvvon dárkkástus-dutkan, gos riska fáhkkatlaš healladávdda oažžut gáffejuhkkiid luhtte rehkenasto logistihkalaš eaktuduvvon regrešuvnna bokte. Sáhttá leahkit nu ahte buoiddes guolli lea rievtti mielde leamašan deaŧaleabbo sámiide go boazobiergu lulli Lapplánddas 1930-1950-logus ja badjeolbmot ain dávjábut borret dan go iežá sámiid ja ruoŧŧelaččat. Iežá sierra erenomášvuohta sámi biebmamis lei alit oassi buoiddis, mális ja vuoššangáfes ja vuolit oassi láibbis, fiberiin ja šaddaduvvon šattuin (Oassedutkan 1). Stuora seammaláganvuođat árbevirolaš sámi biebmamiin, rievtti mielde alit Sami diet score čuoggát, ledje čatnon veahá aliduvvon jámolašvuhtii dievdduid luhtte muhto ii fal nissoniid luhtte (Oassedutkan 2). Biebman mas vuolit oassi kolhydráhtaid ja alit oassi proteiinnat, rievtti mielde alit LHCP čuoggát, ii váikkuhan riskka jápmit, maŋŋel go lea statistihkalaččat jurddašan ahte buoiddi borrat ja mat dát leat dát sajáiduvvon riskafáktorat (Oassedutkan 3). Gáffejuhkan ii lean čatnon eaneduvvon borasdávdariskii, iige eaneduvvon riskii oažžut prostata- gassačoalleborasdávdda. Nissoniin mat juhke vuoššangáfe ≥ 4 geardde/beaivái lei geahpeduvvon riska oažžut čižžeborasdávdda go nissonat mat juhke <1 geardde/beaivái. Ollesgáffe ja brygg-gáffe ledje čatnon eaneduvvon riskii oažžut čižžeborasdávddá nuorat nissoniid luhtte ja geahpeduvvon riskii vuorrasiin luhtte. Dievdduin mat juhke ollu vuoššangáfe lei eaneduvvon riska oažžut borasdávdda (Oassedutkan 4). Dievdduin mat juhke olu brygg-gáfe lei eaneduvvon riska oažžut healladávdda (Oassedutkan 5). Vuorrasit sámiid muitalusat man olu guoli sin vánhemat leat borran boazobierggu ektui 1930-1950-logus, čujuhit ahte bealit main alit kultuvrralaš mearkkašupmi eai dárbbaš seamma nanu objektivalš mearkkašumi atnit. Oassedutkamiid 2-5 bohtosat čujuhit ahte guorahallon bealit árbevirolaš sámi biebmamis ja eallinvuogis eai váikkut gárrasit dearvvašvuođa ja buohccivuođa dábálaš davviruoŧŧelaš ássiid luhtte.
(Lulesamiska) Dán guoradallama ájggom lij sáme biebmov ja viessomvuogev tsuojgodit, ja åtsådit gåk árbbedábak sáme bårråmdábe, stuoräládusebna juohkem ja káffajuhkam nuorttalándak álmmugin, bájnná jábmemav ja bårredávddabalov ja tsåhke-/ varravárredávddabalov. Guoktalågev sáme gatjádaláduvvin sijá äjgádij viessomvuoge ja biebmo birra 50-70 jage dán åvddåla (Oasseåtsålvis 1). Biebbmodáhtá 397 sámes ja 1842 láttes guoradaláduvvin parametragahtes gähttjalimij ja muhtem miere unnemus kvadráhta vuoge (PLS) viehkijn. Gålmmå tjuovvo oasseåtsådime, gájkka kohorttaåtsådime, vuolggin Västerbottena varresvuohtaåtsådimj oassálasstij jábmemårijs jali bårredávddaskihpudagájs (64 603-77 319). Ballamoarremerustallamav dahkin Cox regressionijn. Oasseåtsådibme 2 spiedjildij avtaárvojt árbbedábak sáme biebmon tjuokkesmåhtajn nållå rájes gávtse tjuoggáj. Dat lahkke oassálasstijs gudi bårrin ienemus ruoppsis biergov, buojdes guolev, buojdev, muorjijt ja máleskáfav, oattjoj avtav tjuoggáv juohkka avta bårråmoases, aktan 5 tjuoggá ienemusát. Ájn 3 tjuoggá oattjoj dat lahkke oassálasstijs mij båråj binnemus ruonudisájt, lájbijt ja fiberijt, aktan ienemusát 3 tjuoggá. Oasseåtsådibme 3 spiedjilt vidjurijt kolhydráhtaj ja proteijnaj gaskan biebmon nåv gåhtjodum LCHP (vuolle-kolhydráhta, alla-proteijna) tjuoggáj viehkijn. Alemus LCHP tjuoggájt (=20) oadtjun oassálasste gudi binnemus kolhydráhtajt ja ienemus proteinajt bårrin ja vuolemus LCHP tjuoggájt (=2) oassálasste gudi ienemus kolhydráhtajt ja binnemus proteijnajt bårrin. Oasseåtsådimen 4 åtsådaláduváj bårredávddaballo brygga- ja máleskáffajuhkkijn. Oasseåtsådibme 5 lij aktijdum guoradim-åtsådibme, gånnå káffajuhkkij tsåhkedávddaballo merustaláduváj aktijdam vihkemáhtsadime baktu. Vuordedahtek lij buojdes guolle ájnnasabbo gå boatsojbierggo sámijda oarjje Lapplándan 1930-1950-lågojn ja ájn vilá ällosáme guolev ienebut bårri gå ietjá sáme ja látte. Ietjá sierra merka sáme biebmon lij alep oasse buojdes, máles ja máleskáfas ja unnep oasse lájbes, fiberis ja sáddjidum ruonudisájs (Oasseåtsådibme 1). Árbbedábak sáme biebmo muoduk biebbmo, alep Sami diet score tjuoggáj, aktijaneduváj lasse jábmemijn sierraláhkáj ålmmåj hárráj (Oasseåtsådibme 2). Biebbmo vuolep kolhydráhttaåsijn ja alep proteijnnaåsijn, alla LCHP tjuoggáj, ittjij jábmembalov bájne, maŋŋel gå statistijkalattjat gehtjadam buojddebårråmijt ja ieme ballovidjurijt (Oasseåtsådibme 3). Káffajuhkam lij tjanádum juogu de lasse gájkkásasj bårredávddaballuj, jali lasse prostáhta- bahtatjoallebårredávddaj. Kujnajn gudi máleskáfav juhkin ≥ niellji bäjvváj lij binnep njidtjebårredávddaballo gå buohtastahttá kujnaj gudi < akti bäjvváj juhkin. Ålleskáffa ja bryggakáffa tjanáduváj lasse njidtjebårredávddaballuj nuorap kujnaj hárráj ja binnep vuorrasappoj. Ålmmåjn gudi juhkin edna máleskáfav lij lasse bårredávddaballo vuojŋŋamorgánajn (Oasseåtsådibme 4). Ålmmåjn gudi juhkin edna bryggakáfav lij lasse tsåhkedávddaballo (Oasseåtsådibme 5). Vuorrasap sámij tsuojggoma äjgádij guollebårråmis gå buohtastahttá boatsojbierggobårråmijn 1930-1950-lågo, vuosedi biele alla kultuvrak sisanos e agev dárbaha sämmi nanos objektijvak sisanov adnet. Oasseåtsådimij 2-5 båhtusa vuosedi åtsådum biele árbbedábak sámebiebmos ja viessomvuoges e varresvuodav ja skihpudagáv nuorttalándak álmmuga hárráj heva bájne.
(Sydsamiska) Dan goerehtimmien ulmie lea saemien beapmoem jïh jielemevuekiem buerkiestidh jïh dotkedh guktie aerpievuekien saemien beapmoevuekieh, makrobïepmehtimmiej juekeme jïh prïhtjhjovhkeme jaemedem jïh riskem dijpieh vaajmoe-/ jïh soeneskïemtjelassen muhteste noerhtesvöörjen sïejhmi årroji luvnie. Lea göökteluhkie saemien voeresh goerehtamme daej eejtegi jielemevuekien jïh beapmoen dïehre 50-70 jaepiej juassah (Stuhtjedotkeme 1). Dïsse lissine lea beapmoedaatam goerehtamme 397 saemijste jïh 1842 laedtijste ov-parametrihken gïehtjedimmiej jïh partiellen unnemes kvadraaten vuekien mietie (PLS). Dah golme båetien stuhtjedotkemh, gaajhkh kohortdotkemh, leah dotkeme man gaavhtan jaameme jallh mïetskeåedtjieskïemtjelassh daej luvnie gïeh meatan Västerbottenen healsoedotkemi muhteste (64 603-77 319 dotkemh) jïh riskeryøknemh dorjeme Cox regresjovnen viehkine. Stuhtjedotkemisnie 2 lea mohtedamme guktie aerpievuekien saemien beapmoe vaestede låhkoeraajterasse 0 raejeste 8 raajan. Daate bielie daejstie gïeh meatan gïeh jeenemes rööpses bearkoem, buajtehks gueliem, buejtiem, muerjieh jïh voessjemeprïhtjegem byöpmedamme, leah aktem låhkoem åådtjeme fïere guhte beapmoeelementen åvteste, jeenemes 5 låhkoeh. Dïsse lissine 3 låhkoeh åådtje daate bielie daejstie gïeh meatan gïeh unnemes kruanesaath, laejpiem jïh fiberh byöpmedamme, jeenemes 3 låhkoeh. Stuhtjedotkemisnie 3 daelie mohtede kolhydraath jïh proteinh beapmosne LHCP (vuelehks-kolhydraath, jïlle-proteine) låhkoej viehkine. Jillemes LHCP låhkoem åådtjeme (=20) dah gïeh meatan gïeh vaenemes kolhydraath jïh jeenemes proteinh byöpmedamme jïh vueliehkommes LHCP låhkoem (=2) åådtjeme dah gïeh meatan gïeh jeenemes kolhydraath jïh vaenemes proteinh byöpmedamme. Stuhtjedotkemisnie 4 riskem goerehtamme mietskeåedtjieskïemtjelassem åadtjodh brygg- jïh voessjemeprïhtjegejovhkiji luvnie. Stuhjtedotkeme 5 lïj tjetskeme-dotkeme gusnie riskem ryöknoe logistihken regresjovnen baaktoe jis maahta faahketji vaajmoedåeriesmoerh åadtjodh prïhtjhjovhkiji luvnie. Buajtehks guelie meehti vihkielåbpoe årrodh båatsoesaemide goh bovtsebearkoe åarjel Lapplaantesne 1930-1950-låhkosne jïh daamhtah båatsoesaemieh daam byöpmedieh jeenebe goh jeatjah saemieh jïh laedtieh. Jeatjah sïejhmi sjïere vuekieh saemien beapmosne lea jïlle stuhtje buejteste, maeleste jïh voessjemeprïhtjegistie jïh vuelie stuhtje laejpeste, fiberistie jïh kruanesaatijste (Stuhtjedotkeme 1). Jeenh saemien aerpievuekien beapmoe, jïlle Sami diet score låhkoeh, provhki vuesiehtidh vaenie jeananamme jaemede ålmaj gaskemsh bene ij nyjsenæjjaj gaskemsh (Stuhtjedotkeme 2). Beapmoe man vuelehks stuhtje kolhydraath jïh stoerre stuhtje proteijnh, jeenh LCHP låhkoeh, ij leah dïjpeme riskem jaemedh, dan mænggan goh lea ussjedamme statistihken muhteste man jeene buejtiem byöpmedidh jïh sijjiedahteme riskefaktovrh ussjedamme. (Stuhtjedotkeme 3). Prïhtjhjovhkeme ij leah tjoelmesovveme jeananamme mïetskeåedtjieriskese, jallh jeananamme riskese prostaate-voeresbuejtiemïetskeåedtjiem åadtjodh. Nyjsenæjjah gïeh voessjemeprïhtjegem jovhkeme ≥ 4 aejkien/biejjesne unnemes riskem utnin njammamïetskeåedtjiem åadtjodh nyjsenæjjaj muhteste gïeh jovhkeme <1 aejkien/biejjesne. Ellies prïhtjege jïh bryggeprïhtjege lea tjoelmesovveme jeananamme riskese njammamïestkeåedtjiem åadtjodh noere nyjsenæjjah luvnie jïh unniedamme riskem voeresi luvnie. Ålmah gïeh jeenh voessjemeprïhtjegem juvhkieh jeananamme riskem utnieh mïetskeåedtjiem åadtjodh girsesne (Stuhtjedotkeme 4). Ålmah gïeh jeenh bryggeprïhtjegem jovhkeme jeananamme riskem utnieh vaajmoedåeriesmoerem åadjtodh (Stuhtjedotkeme 5). Dah saemien voeresi soptsestimmieh man jeeneh gueliem daej eejtegh leah byöpmedamme bovtsebearkoem muhteste 1930-1950-låhkosne, vuesehte ahte daate bielie man vihkeles kultuvren sisvege ij eejnegen seamma objektiven sisvegem utnieh. Illeldahkh stuhtjedotkemijstie 2-5 vuesiehtieh ahte dah bielieh mejtie lea goerehtamme saemien aerpienvuekien beapmoen jïh jielemevuekien muhteste eah healsoem jïh skïemtjelassem dïjph jeenebe goh sïejme noerhtesvöörjen årrojh.
(Umesamiska) Dahte guoreteme suptseste saamien beäpmoen jah jielemevuökien biire jah giehtjedie guktie aarpievuökien saamien beäpmoeh, oajviebeäpmoeh jah kaavoeh mietete jaameke vahkake jah cancerenne jah vajmoen/ virreveättennea nuorthen allmetjeih luunie. Guökteluhke saamieih boariesh gihtjedihke lie elltie eihtegeh jielemevuökien jah beäpmoen biire dann baelie 50-70 jaapieh (Oasie 1). Jieneh beäpmoe-dataede dahkedihke lie 397 saamieiheste jah 1842 ruotseiheste dennake viehketihenne ieh parmetriske giehtjedemeh jah partiellen unnemes kvadraten vuökien miete (PLS). Dah gullme oasieh boatien kohort- luhkemeh, allkemme lie jaamemeste jall canceremeste mieteih Västerbottenen varaasgiehtjemeih luunie (64603-77319 ollu) vahkake-tsiehkesjeme dahkedihke Cox-enne regressione. Oasienne 2 vuöjnedihke leh akte laakatjenne aarpievuökien saamien beäpmoeh vuösstede akte tsiehkesjerairoe 0 – 8. Dahte bielie deistie gieh jienemes ruöpses beärrkoede, buöjteks guöliede, buöjtiede borrein jah vuossjeme kaavoede juukein, akte tsiehkie fierte beäpmoih outeste otjoin, jienemes 5 tsiehkieh.Vielie 3 tsiehkieh dahte bielie otjoin gieh unnemes jaamoede jah urhtsede, laipiede jah fiberede borrein, jienemes 3 tsiehkeh. Oasienne 3 vuöjnedihke aktevuotta gasske kolhydrateh jah proteieneh beäpmoenne LCHP-esne (vuöleke kolhydrateh, jylloeke-proteineh) tsiehkie. Jyllemes LCHP tsiehkieh (=20) dainie mietenne unnemes kolhydrateh jah ollomes proteineh borrein jah unnemes LCHP tsiehkieh (2) dainie mietenne ollomes kolhydrateh jah unnemes proteineh borrein. Oasienne 4 giehtjedihke vahkake cancerede brygg- jah vuossjeme kaavoe juukejenne. Oasie 5 tjohkenne lin kontrolle- giehtjedeme vahkake hiehke vaajmoe-narrenne kaavoe-juukejenne tsiehkiesjdihke logistiske regressionenne. Buöjteke guölieh borretdihke mahtein vieliebe buutsebeärrkoeste saamieihesne oarrjel saamien eätname 1930-1950 jaapienne jah vieliebe borretdihke buutsesaamieiheste guh jeätja saamieh jah ruotse-allmetjeh. Jeätja siejhme sierreme saamien beäpmoesne lin akte jylloeke oasie buöjtie-, viire-, jah vuossjeme kaavoeste jah akte vuöleke oasie laipie-, fibere-, joamoe jah urhtseste (Oasie 1). Ollu aktelaaka aarpievuökien saamien beäpmoeh, ollu Sami diet score tsiehkieh tjohkan lin vieliebe jaameme ollmaihenne sierrelaaka (oasie 2). Beäpmoihenne unne kolhydrateh jah ollu proteineh, ollu LCHP tsiehkie, ieh vahkake lasste jaamet, dann mingjelen guh statistiske ussjede valltedihke leh borremmiean gallane buöjtieste jah vihties vahkake faktoreiheste (oasie 3). Kaavoejuukeminne lin ieh vielebe aarpievuökien cancer-vahkake tjohkenne, jall vielebe vahkake prostate-kolorektale-cancere. Nyesenejah guh vuossjeme kaavoe juukein ≥4 aikieh/biejvie unnebe vahkake nitje-cancereb lin muhteste nyesenejanneh gieh <1 aikie/biejvie juukein. Gaihkekaavoe jah brygg-kaavoe lie tjoahkan vielebe nitje cancereb nyesenejanne jah unnebe vahkake boariesh nyesenejaihenne. Ollma guh ollu vuossjeme kaavoeb juukein cancereste gonkelmesenne vieliebe vahkake otjoin (oasie 4). Ollma guh ollu brygg-kaavoe vajmoe-narreme vieleb vahkake otjoin (oasie 5). Dah boariesh saamieh suptsestemeh man jingje guöliede elltie eihtegeh buutsebeärrkoeh borrein 1930-1950-aikie, vuösiete dahte bielie veäksekes kulture miele ieh gaihke aikie darpesjedennake veäksekes objektive miele leh. Oasie 2-5 vuösiete dah giehtjedemes dahte bielie aarpievuökien saamien beäpmoen jah jielemen vuökien ieh varaas jah skieptjeme mietete ieh nuorthen almetejeh ollu.
Pulsford, Richard Michael. "Sedentary behaviour and health." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15679.
Повний текст джерелаForés, Raurell Rosa. "Incidència d´arteriopatia perifèrica i morbi-mortalitat cardiovascular després de 5 anys de seguiment de la cohort poblacional ARTPER." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/650852.
Повний текст джерелаThis thesis was designed to improve the knowledge of peripheral arterial disease epidemiology , to study the involved factors in its onset and the cardiovascular morbidity and mortality impact in our environment. After 5 years of follow - up of a population cohort aged over 49 years (ARTPER cohort), 3 related studies were conducted. The first study evaluated the incidence of peripheral arterial disease at 5 years of follow-up of the ARTPER population cohort and the factors associated with its onset. The second study evaluated the contribution of the ankle-brachial index in the reclassification of cardiovascular risk according to Framingham and REGICOR the risk scores. The third study evaluated the evolution and the degree of control of the classics cardiovascular risk factors, after 5 years of cohort monitoring and its relation to the incidence of peripheral arterial disease. The ARTPER cohort was created between October 2006 and June 2008 to study the prevalence of peripheral arterial disease recruiting 3,786 individuals > 49 years old from 24 health centers in the metropolitan area of Barcelona and the Barcelonès Nord-Maresme. Subsequently, a telephone tracking and review of the medical history was carried out every 6 months from the inclusion of the participants until 2016. Between 2011-2012 the participants were re-examined in a second face-to-face visit to evaluate the incidence of peripheral arterial disease. The participation was 77%. As a result of this thesis the following articles have been published: Alzamora MT, Forés R, Pera G, Baena-Díez JM, Heras A, Sorribes M, Valverde M, Muñoz L, Mundet X, Torán P. Incidence of peripheral arterial disease in the ARTPER population cohort after 5 years of follow-up. BMC Cardiovasc Disord. 2016; 16: 8. FI: 1,832. Q3. Forés R, Alzamora MT, Pera G, Baena-Díez JM, Mundet-Tuduri X, Torán P. Contribution of the ankle-brachial index to improve the prediction of coronary risk: the ARTPER cohort. PLoS One. 2018; 13(1): e0191283. FI: 2,806 Q1. Forés R, Alzamora MT, Pera G, Valverde M, Angla M, Baena-Díez JM, Mundet-Tuduri X. Evolución y grado de control de los factores de riesgo cardiovascular tras 5 años de seguimiento y su relación con la incidencia de arteriopatía periférica: cohorte poblacional ARTPER. Med Clin (Barc). 2017;148(3):107–113. FI: 1,125. Q3. Concusions: The peripheral arterial disease incidence in the ARTPER cohort after 5 years of follow-up was 8.6 cases / 1,000 person-years. In people <65 years old, it is higher in men, equaling> 75 years in both sexes. Smoking, age and limitation for physical exercise are the associated factors with decreased ankle-brachial index and the appearance of peripheral arterial disease. Adding the ankle-brachial index to the REGICOR score improves the reclassification at high risk cardiovascular about 7%. An ankle-brachial index <0.9 is associated with a higher incidence of coronary and cerebrovascular events in the population cohort, with low cardiovascular risk, ARTPER. The classic cardiovascular risk factors prevalence and its treatment increase after 5 years of follow-up, but only optimal control is achieved in 7% of patients. Poorly controlled hypertension doubles the risk of having peripheral arterial disease and smoking fivefold.
Ström, Möller Christina. "The Resting Electrocardiogram and Risk for Cardiovascular Disease : A Population-Based Study in Middle-Aged Men with up to 32 Years of Follow-Up." Doctoral thesis, Uppsala University, Department of Public Health and Caring Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7210.
Повний текст джерелаThe aim was to contribute to the optimal use of the resting ECG by exploring, in middle-aged and elderly men, the development and regression of ECG abnormalities; the prognostic value of the ECG for cardiovascular disease compared to conventional risk factors; and the impact of age at baseline and follow-up time for prediction of cardiovascular disease.
It was based on the Uppsala Study of Adult Men cohort that was started in 1970. Participants were examined at ages 50, 70, 77, and 82, with annual updates on mortality and in-hospital morbidity using national registries.
The studies indicated that the prevalence of silent MI and frequency of regression of major Q/QS patterns may be higher than previously believed. Considering that persistent T wave abnormalities and ST segment depression carried twice as high a risk for future cardiovascular disease (CVD) mortality as new or reverted abnormalities, the results suggested that serial electrocardiograms (ECG) would contribute to proper risk assessment. Also, the inclusion of ischemic ECG findings significantly increased the predictive power of the Framingham score at age 70 for CVD.
While hypertension and dyslipidemia were consistent long-term risk factors for myocardial infarction at ages 50 and 70, the length of follow-up period and age at baseline affected the predictive power of ECG abnormalities, fasting insulin, BMI, and smoking.
For stroke, midlife values for blood pressure and ECG abnormalities retained prognostic value over long follow-up periods, even though they improved when re-measured in elderly participants. ApoB/apoA1 ratio, driven by apoA1, was associated with stroke in elderly but not middle-aged men. Hyperinsulinemia and diabetes mellitus were more specifically associated with ischemic stroke than with any-cause stroke.
In summary, the resting ECG carried prognostic information beyond conventional risk factors. Even though the low prevalence of ECG abnormalities at the age of 50 calls into question the role of the ECG as a screening tool, the additional risk information it carries with it justifies its regular and repeated registration above the age of 50.
Mayaud, Louis. "Prediction of mortality in septic patients with hypotension." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:55a57418-de16-4932-8a42-af56bd380056.
Повний текст джерелаSimba, Kudakwashe. "The impact of vascular calcification among dialysis dependent South African CKD patients. A five year follow up study. Cardiovascular mortality and morbidity, ethnic variation and hemodynamic correlates." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31257.
Повний текст джерелаFisher, Kimberly A. "Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/717.
Повний текст джерелаFisher, Kimberly A. "Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/717.
Повний текст джерела