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Статті в журналах з теми "Cardio-Metabolism risk"
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Chandiok, Ketaki, and Rakash Ranjan Monda. "One Carbon Metabolism and Cardio-Metabolic risk." Voice of Intellectual Man- An International Journal 7, no. 2 (2017): 135. http://dx.doi.org/10.5958/2319-4308.2017.00029.9.
Повний текст джерела
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Li, Ling-Jun, Izzuddin M. Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan, and Jie Jin Wang. "Effect of gestational diabetes and hypertensive disorders of pregnancy on postpartum cardiometabolic risk." Endocrine Connections 7, no. 3 (March 2018): 433–42. http://dx.doi.org/10.1530/ec-17-0359.
Повний текст джерелаАнотація:
Aims The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP’s individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic syndrome (MetS), abnormal glucose metabolism and hypertension (HTN)). Methods Of participants from a Singapore birth cohort, 276 mothers attending the 5-year postpartum visit were included in this study. During this visit, we collected mothers’ history of GDM and HDP in all live births in a chronicle sequence and assessed the cardio-metabolic risks based on blood pressure, anthropometry and a panel of serum biomarkers. We diagnosed MetS, abnormal glucose metabolism and HTN according to Adult Treatment Panel III 2000 and World Health Organization guidelines. Results Of 276 mothers, 157 (56.9%) had histories of GDM while 23 (8.3%) had histories of HDP. After full adjustment, we found associations of GDM episodes with postpartum abnormal glucose metabolism (single episode: relative risk (RR) 2.9 (95% CI: 1.7, 4.8); recurrent episodes (≥2): RR = 3.8 (2.1–6.8)). Also, we found association between histories of HDP and HTN (RR = 3.6 (1.5, 8.6)). Having either (RR 2.6 (1.7–3.9)) or both gestational complications (RR 2.7 (1.6–4.9)) was associated with similar risk of postpartum cardio-metabolic disease. Conclusions Mothers with GDM or HDP had a threefold increased risk of postpartum abnormal glucose metabolism or HTN, respectively. Having both GDM and HDP during past pregnancies was not associated with additional risk of postpartum cardio-metabolic diseases beyond that associated with either complication alone.
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Kashukh, Ye A., and V. T. Ivashkin. "Probiotics, metabolism and the functional condition of cardio-vascular system." Russian Journal of Gastroenterology, Hepatology, Coloproctology 26, no. 1 (August 12, 2016): 8–14. http://dx.doi.org/10.22416/1382-4376-2016-26-1-8-14.
Повний текст джерелаАнотація:
The aim of review. To characterize possible relation between microbiome and cardio-vascular system structural and functional state. Key points. Along with traditional concepts on the risk factors of atherosclerosis and cardio-vascular diseases development one should take into account data on the new pathogenic mechanisms for these diseases. According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. Probiotics, that are mainly prescribed at gastroenterological diseases, may be applied for correction of cardiovascular risk factors as well. Obtained data demonstrate that intake of certain probiotic strains may be applied as a successful treatment of atherosclerosis, systemic hypertension, metabolic syndrome and heart failure. Conclusion. Microbiome may be involved in development of cardio-vascular diseases and atherosclerosis due to metabolic symbiosis with the host. Probiotics may be applied as preventive medication for correction of metabolic disorders that result in development of cardio-vascular diseases and atherosclerosis.
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Fatunde, Olubadewa A., and Sherry-Ann Brown. "The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology." International Journal of Molecular Sciences 21, no. 2 (January 17, 2020): 604. http://dx.doi.org/10.3390/ijms21020604.
Повний текст джерелаАнотація:
As many novel cancer therapies continue to emerge, the field of Cardio-Oncology (or onco-cardiology) has become crucial to prevent, monitor and treat cancer therapy-related cardiovascular toxicity. Furthermore, given the narrow therapeutic window of most cancer therapies, drug-drug interactions are prevalent in the cancer population. Consequently, there is an increased risk of affecting drug efficacy or predisposing individual patients to adverse side effects. Here we review the role of cytochrome P450 (CYP450) enzymes in the field of Cardio-Oncology. We highlight the importance of cardiac medications in preventive Cardio-Oncology for high-risk patients or in the management of cardiotoxicities during or following cancer treatment. Common interactions between Oncology and Cardiology drugs are catalogued, emphasizing the impact of differential metabolism of each substrate drug on unpredictable drug bioavailability and consequent inter-individual variability in treatment response or development of cardiovascular toxicity. This inter-individual variability in bioavailability and subsequent response can be further enhanced by genomic variants in CYP450, or by modifications of CYP450 gene, RNA or protein expression or function in various ‘omics’ related to precision medicine. Thus, we advocate for an individualized approach to each patient by a multidisciplinary team with clinical pharmacists evaluating a treatment plan tailored to a practice of precision Cardio-Oncology. This review may increase awareness of these key concepts in the rapidly evolving field of Cardio-Oncology.
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Ronchi, Cristina L., Elisa Verrua, Emanuele Ferrante, Gwendolyn Bender, Elisa Sala, Andrea G. Lania, Martin Fassnacht, et al. "Long-term effects of radiotherapy on cardiovascular risk factors in acromegaly." European Journal of Endocrinology 164, no. 5 (May 2011): 675–84. http://dx.doi.org/10.1530/eje-10-1105.
Повний текст джерелаАнотація:
ObjectiveRadiation therapy (RT) is a useful adjuvant tool for acromegalic patients not cured by surgery and/or not responding to pharmacotherapy. However, its specific effects on cardio- and cerebrovascular morbidity are still on debate.DesignRetrospective analysis of 42 acromegalic patients cured after conventional radiotherapy (CRT, n=31) or radiosurgery by gamma-knife (GKRS, n=11) followed for a median period of 16.5 years (range: 2–40). Totally, 56 patients cured by surgery alone, with similar GH/IGF1 levels and duration of disease remission, served as control group.MethodsChanges in cardiovascular risk factors, such as body mass index, glucose metabolism, insulin resistance, blood pressure, and lipid profile (pre-defined primary end point) and occurrence of new major cardio- and cerebrovascular events (secondary end point) during follow-up.ResultsThe number of obese, hypertensive, and dyslipidemic subjects increased over time only in patients cured with RT. In contrast, the glucose response to the oral glucose tolerance test and the percentage of subjects with glucose alterations improved only in controls. As expected, the percentage of patients with pituitary failure was deeply higher among RT patients than among controls (86 vs 30%, P<0.0005). Despite these findings, a similar number of RT patients and controls developed major cardio- or cerebrovascular events (4/42 vs 3/56, P: NS). No differences were found between CRT and GKRS subgroups.ConclusionsPrevious RT seems to be associated with a worse metabolic profile in acromegalic patients studied after a long-term follow-up. Nevertheless, a direct link between RT and cardiovascular events remains to be proven.
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Rajak, Devraj, Deepali Sahu, Anushree Jain, Rubeena Khan, Basant Khare, Prateek Kumar Jain, and Bhupendra Singh Thakur. "Review on Toxicity of Antihypertensive Drugs." Asian Journal of Dental and Health Sciences 2, no. 4 (December 15, 2022): 64–68. http://dx.doi.org/10.22270/ajdhs.v2i4.28.
Повний текст джерелаАнотація:
Adverse drug reactions are common and pose a serious health problem, limiting treatment options, causing compliance issues, and even leading to therapy discontinuation. Hypertension is a chronic disease that is regarded as a major risk factor for cardiovascular disease. To achieve a target blood pressure in an individual patient, a wide range of anti-hypertensive agents are available as single or combination therapy, whereas combination therapy increases the risk of developing Adverse Drug Reaction. Hypertensive patients frequently have coexisting disease conditions such as hyperlipidemia, impaired glucose metabolism, and renal impairment, which increase the risk of Cardio Vascular morbidity and mortality. When treating hypertensive patients, comprehensive management of both hypertension and concomitant Cardio Vascular Disease risk factors is essential. Some of the rare and serious Adverse Drug Reactions that occurred in patients treated with these drugs included beta-blockers causing psoriasis, calcium channel blockers causing gingival hyperplasia, peripheral oedema, Angiotensin Converting Enzyme inhibitors causing ankle oedema, and thiazide diuretics causing hyponatremia and hyperglycemia. Asymptomatic hypertension is more common and necessitates lifelong treatment with antihypertensive agents, predisposing to Adverse Drug Events.In order to improve treatment outcomes and reduce morbidity and mortality associated with adverse drug reactions, healthcare professionals must monitor adverse drug reactions in patients taking antihypertensive drugs. Keywords: Adverse drug reactions, Hypertension, hyperlipidemia, glucose metabolism
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Kiluk, Małgorzata, Janina Lewkowicz, Dariusz Pawlak, and Anna Tankiewicz-Kwedlo. "Crosstalk between Tryptophan Metabolism via Kynurenine Pathway and Carbohydrate Metabolism in the Context of Cardio-Metabolic Risk—Review." Journal of Clinical Medicine 10, no. 11 (June 4, 2021): 2484. http://dx.doi.org/10.3390/jcm10112484.
Повний текст джерелаАнотація:
Scientific interest in tryptophan metabolism via the kynurenine pathway (KP) has increased in the last decades. Describing its metabolites helped to increase their roles in many diseases and disturbances, many of a pro-inflammatory nature. It has become increasingly evident that KP can be considered an important part of emerging mediators of diabetes mellitus and metabolic syndrome (MS), mostly stemming from chronic systemic low-grade inflammation resulting in the aggravation of cardiovascular complications. An electronic literature search of PubMed and Embase up to March 2021 was performed for papers reporting the effects of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), xanthurenic acid (XA), anthranilic acid (AA), and quinolinic acid (QA), focusing on their roles in carbohydrate metabolism and the cardiovascular system. In this review, we discussed the progress in tryptophan metabolism via KP research, focusing particular attention on the roles in carbohydrate metabolism and its complications in the cardiovascular system. We examined the association between KP and diabetes mellitus type 2 (T2D), diabetes mellitus type 1 (T1D), and cardiovascular diseases (CVD). We concluded that tryptophan metabolism via KP serves as a potential diagnostic tool in assessing cardiometabolic risk for patients with T2D.
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Cuciureanu, Tudor, Stefan Chiriac, Madalina Chiorescu, Irina Girleanu, and Anca Trifan. "Chronic hepatitis C virus infection: a new modifiable cardio-metabolic risk factor ?" Medicine and Pharmacy Reports 90, no. 3 (July 25, 2017): 251–55. http://dx.doi.org/10.15386/cjmed-793.
Повний текст джерелаАнотація:
Chronic hepatitis C infection is a systemic disease that leads to a high risk of cirrhosis and hepatic carcinoma, as well as extrahepatic related disorders, immune –related and metabolic alterations such as glucose metabolism impairment and steatosis, thus being a new cardio-metabolic risk factor. It has been shown that, due to chronic inflammation, HCV infection has a direct effect on the arterial wall, initiating endothelial dysfunction which is the first step in atherosclerotic processes with proatherogenic effects and numerous cardiovascular events. The recent data emphasize that HCV infection can induce insulin resistance in the liver and peripheral tissues through multiple mechanisms which interfere with insulin signaling, inducing the production of several proinflammatory cytokines, and modify the lipid metabolism with the result of hepatic steatosis, which is more pronounced in patients with HCV. The emergence of new direct acting, interferon-free antiviral treatment, leading to HCV cure in most cases with a satisfactory safety profile is, according to numerous studies, improving the glucose metabolism disorders and lowering the number of cardiovascular events in patients who obtained sustained viral response, thiugh further studies are needed to clarify definitively the role of HCV infection in cardiovascular and metabolic alterations, as well as the impact of viral eradication on cardiovascular outcomes.
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Kovtun, O. P., and P. B. Tsyvian. "MATERNAL NUTRITION AND THE PROBLEM OF INTRAUTERINE DISEASE PROGRAMMING IN CHILDREN." Annals of the Russian academy of medical sciences 73, no. 3 (July 9, 2018): 190–94. http://dx.doi.org/10.15690/vramn988.
Повний текст джерелаАнотація:
Environmental conditions during perinatal development such as maternal undernutrition or overnutrition can program changes in the integration among physiological systems leading to cardio-metabolic diseases. This phenomenon can be understood in the context of the phenotypic plasticity and refers to the adjustment of a phenotype in response to environmental input without genetic change. Experimental studies indicate that fetal exposure to an adverse maternal environment may alter the morphology and physiology that contribute to the development of cardio-metabolic diseases. The significance and role of genetic polymorphism, markers of chronic inflammation, oxidative stress, endothelial dysfunction, leptin synthesis disruption, rennin-angiotensin system in intrauterine cardio-metabolic disease programming are discussed. The study demonstrated that both maternal protein restriction and overnutrition alter the central and peripheral control of arterial pressure and metabolism. Breastfeeding may have beneficial effect on obesity risk later in life in genetically predisposed groups. Understanding the mechanisms which affect health outcomes in the offspring influenced by the macronutrient composition of the maternal diet during pregnancy or lactation may lead to new maternal nutrition recommendations, disease prevention strategies, and therapies that reduce the increasing incidence of cardio-metabolic diseases in children and adults.
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Podzolkov, V. I., E. A. Gladysheva, and A. E. Bragina. "Moxonidin in combined therapy of metabolic syndrome." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 13, no. 4 (August 28, 2007): 246–49. http://dx.doi.org/10.18705/1607-419x-2007-13-4-246-249.
Повний текст джерелаАнотація:
The paper presents the results of 24-weeks follow-up and treatment patients with metabolic syndrome. It shows antihypertensive effect of imidazoline-receptor agonist moxonidine and hypolipidemic effect of micronized fenofibrate in patients with metabolic syndrome. The combination demonstrate synergic action on carbohydrate and uric acid metabolism. Thus, it can significantly decrease the level of cardio-vascular risk (SCORE) in patients with metabolic syndrome.
Дисертації з теми "Cardio-Metabolism risk"
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Rigal, Eve. "Impact à long terme de la programmation nutritionnelle postnatale sur le risque cardio-métabolisme et sur la sensibilité aux lésions d'ischémie-reperfusion in vivo chez la souris." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCI017.
Повний текст джерелаАнотація:
Les troubles nutritionnels survenant pendant les périodes fœtales et postnatales peuvent être responsables d'une prédisposition aux maladies cardio-métaboliques à l'âge adulte. Le modèle de Suralimentation PostNatale (SAPN), induit par la réduction de la taille des portées, récapitule de façon pertinente les mécanismes physiopathologiques d’une programmation d’un risque cardio-métabolique accru chez l’individu, qu’il soit de sexe masculin ou féminin. Cependant, dans le domaine préclinique, la majorité des travaux a été conduit chez des rongeurs mâles de 2 à 4 mois d’âge.Chez les souris mâles, la SAPN a induit un surpoids associé à des désordres du métabolisme glucidique de façon précoce et permanente (4 à 18 mois). La fonction contractile cardiaque était diminuée par la SAPN et la sensibilité des cœurs aux lésions d’ischémie-reperfusion (I/R) induites in vivo était accrue et associée à une augmentation de la masse du tissu adipeux péricardique ainsi que de son statut inflammatoire. Chez les femelles, la SAPN à induit des altérations cardio métaboliques similaires, cependant, la sensibilité des cœurs aux lésions d’I/R induites in vivo n’a pas été impactée.Ces résultats montrent qu’une SAPN prédispose l’organisme des souris mâles et femelles aux maladies cardio-métaboliques précocement (dès 4 mois) et durablement (jusqu’à 18 mois de vie), mais qu’elle n’affecte que les mâles pour la susceptibilité aux lésions ischémiques cardiaques.Ce modèle original de SAPN constitue un modèle préclinique pertinent de syndrome métabolique tel qu’il est généralement constaté chez l’humain, et sur lequel des études physiopathologiques et thérapeutiques plus représentatives de la pathologie clinique pourraient être menéesNutritional disorders occurring during the foetal and postnatal periods may be responsible for a predisposition to cardio-metabolic diseases in adulthood. The PostNatal OverFeeding (PNOF) model, induced by litter size reduction, pertinently recapitulates the pathophysiological mechanisms of a programmed increase of cardiometabolic risk in Humans. However, most of preclinical data has been obtained in young male animals.In male mice, PNOF induced an increase in body weight associated with glucose metabolism impairment at young and older ages (4 to 18 months). Cardiac contractile function was reduced by PNOF and the sensitivity of hearts to in vivo ischemia-reperfusion (I/R) injury was increased and associated with an augmentation in pericardial adipose tissue mass and inflammatory status. In females, PNOF induced similar cardio-metabolic alterations, however, the sensitivity of hearts to I/R lesions induced in vivo was not impacted.These results show that PNOF predisposes the organism of male and female mice to cardio-metabolic diseases from the young (4 months) to the older ages (up to 18 months); however, PNOF only affects males for an increased sensitivity to ischemic cardiac lesions.This original model of PNOF could constitute a model of “natural” metabolic syndrome on which physiopathological and therapeutic studies could be carried out
Частини книг з теми "Cardio-Metabolism risk"
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Jacob, Stephan, Matthias Leschke, and Andrew J. Krentz. "Type 2 diabetes management: from a glucose-centric approach to cardio-renal risk reduction." In Cardiovascular Endocrinology and Metabolism, 221–32. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-99991-5.00013-9.
Повний текст джерелаТези доповідей конференцій з теми "Cardio-Metabolism risk"
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Kolyaskina, M. M., A. A. Kislyakova, and P. Sh Osmanova. "EMPLOYEES OPERATING AND MAINTAINING WIRED AND WIRELESS COMMUNICATION DEVICES CARDIOVASCULAR RISK DEVELOPMENT MONITORING." In The 4th «OCCUPATION and HEALTH» International Youth Forum (OHIYF-2022). FSBSI «IRIOH», 2022. http://dx.doi.org/10.31089/978-5-6042929-6-9-2022-1-124-127.
Повний текст джерелаАнотація:
Introduction: Heart disease has been the leading cause of death in the world for the past 20 years. The main pathogenetic mechanism leading to the development of coronary disease and fatal complications is atherosclerosis. The goal of study is to assess cardiovascular risks in workers operating and maintaining communication facilities based on wired and wireless technologies. Materials and methods: 50 employees operating in the field of communications based on wired and wireless technologies health state survey was carried out. Lipid metabolism parameters were assessed, the risks of cardiovascular complications were calculated by SCORE and ASCORE scales, and «Vascular age» was determined. Results: High cardiovascular risk was detected in 40% of examined patients. Elevated values of atherogenic index were already observed in middle-aged people (45-60years). Assessment of SCORE and ASCORE scales revealed a high risk of cardiovascular complications development in middle-aged and elderly people. An excess of vascular age compared to real one in 45-60 years and 61-74 years by an average of 7 (p<0.001) and 5 (p=0.026) years, respectively, was established. Conclusion: The most pronounced changes were found in people of working age (45-60 years). Thus, it is necessary to develop preventive measures aimed to cardio screening with of early signs of health disorders detection, to prevent the development of cardiovascular complications and groups at increased risk of diseases formation.