Дисертації з теми "Cardiac Functional Assessment"
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Puyol, Anton Esther. "A multimodal spatiotemporal atlas for cardiac functional assessment." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/a-multimodal-spatiotemporal-atlas-for-cardiac-functional-assessment(7c37e366-728b-4cb0-bffc-33f467c67354).html.
Повний текст джерелаFinnemore, Anna. "Quantitative assessment and functional correlates of cardiac mechanics and energetics in newborn infants." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25281.
Повний текст джерелаDreyer, Liezel Ann. "Current practices in cardiac rehabilitation : implications for scope of rehabilitation and assessment of functional capacity." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/2750.
Повний текст джерелаPepera, Garyfallia K. "Assessments of functional capacity in cardiac rehabilitation." Thesis, University of Essex, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536959.
Повний текст джерелаChan-Dewar, Fang. "Cardiac mechanics and activation delay in the assessment of exercise-induced changes in cardiac function." Thesis, Liverpool John Moores University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549431.
Повний текст джерелаBrookes, Carl I. O. "The evaluation and assessment of right ventricular function using conductance catheters." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326042.
Повний текст джерелаScott-Park, Freda Marion. "Quantitative assessment of the cardiac function in dogs using the apexcardiogram." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/29988.
Повний текст джерелаGrigorescu, Fredriksson Alexandru. "Blood flow specific assessment of ventricular function : Visualization and quantification using 4D flow CMR." Doctoral thesis, Linköpings universitet, Avdelningen för kardiovaskulär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143417.
Повний текст джерелаMcIntosh, Robert A. "Novel contractility assessments in the evaluation of cardiac function : applications to common clinical practice and cardiac device therapy." Thesis, St George's, University of London, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.754069.
Повний текст джерелаFonseca, Carissa Grace. "Assessment of left ventricular diastolic function with three dimensional cardiac magnetic resonance imaging." Thesis, University of Auckland, 2004. http://hdl.handle.net/2292/5715.
Повний текст джерелаCoats, Andrew J. S. "Doppler aortic velocimetry and the assessment of cardiac function in chronic heart failure." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305499.
Повний текст джерелаLawless, Michael. "An integrative assessment of phosphodiesterase 5 inhibition on cardiac function in heart failure." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/an-integrative-assessment-of-phosphodiesterase-5-inhibition-on-cardiac-function-in-heart-failure(5d4e804f-591d-4131-8443-9f8c1b722f5d).html.
Повний текст джерелаSwoboda, Peter Paranthaman Louis. "Assessment of subclinical cardiac changes in structure and function by cardiovascular magnetic resonance." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/12592/.
Повний текст джерелаJorstig, Stina. "On the assessment of right ventricular function using cardiac magnetic resonance imaging and echocardiography." Doctoral thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51662.
Повний текст джерелаChambers, John Boyd. "Studies on the use of Doppler ultrasound in the assessment of prosthetic cardiac valve function." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390391.
Повний текст джерелаLaFountain, Richard A. "Validation of VO2max Assessment and Magnetic Resonance Cardiac Function Measurements Utilizing an MRI Compatible Treadmill." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405431417.
Повний текст джерелаOtsuka, Naoki. "Assessment of cardiac sympathetic function with iodine-123-MIBG imaging in obstructive sleep apnea syndrome." Kyoto University, 1997. http://hdl.handle.net/2433/202173.
Повний текст джерелаCabrita, Ines Zimbarra. "The heart in Sickle Cell Disease : role of non invasive cardiac imaging by advanced echocardiography and cardiac magnetic resonance assessment of myocardial function." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24569.
Повний текст джерелаBacklund, Emma. "Assessment of ventricular morphology using echocardiography in Ornate tinamous (Nothoprocta ornata) and domestic chickens (Gallus domesticus)." Thesis, Linköpings universitet, Biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103754.
Повний текст джерелаWright, D. J. "Towards a more comprehensive, non-invasive evaluation of cardiac function in the assessment of therapeutic interventions." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399663.
Повний текст джерелаMahmod, Masliza. "Multiparametric cardiovascular magnetic resonance for the assessment of cardiac function and metabolism in hypertrophy and heart failure." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ff24c167-e00d-4c6d-9809-82203979ba7a.
Повний текст джерелаMcLure, Lindsey Elizabeth Robertson. "The role of cardiac magnetic resonance imaging in the assessment of right ventricular function in pulmonary hypertension." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6884/.
Повний текст джерелаParamasivam, Gowrishankar. "Ultrasound assessment of fetal cardiac function and risk of adverse obstetric and neonatal outcomes in term fetuses." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/48187.
Повний текст джерелаUnsworth, Bethan. "The assessment of right ventricular function during and following routine cardiac surgery and the evaluation of preserving pericardial integrity." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9048.
Повний текст джерелаAugustine, Daniel. "Cardiovascular magnetic resonance deformation imaging by feature tracking for assessment of left and right ventricular structure and function." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7872.
Повний текст джерелаAfiune, Fernanda Guedes. "Alterações cognitivas em pacientes idosos com insuficiência cardíaca." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/7524.
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Among the various diseases that affect the elderly stand out from them cardiovascular disease among them heart failure (HF). Recently seeks to check for cognitive impairment associated with physical and psychological damage commonly known in the IC. We analyzed a population of patients with heart failure in order to compare their cognitive performance with that of individuals with normal aging in paired age. It was also verified whether there was any more specific impairment of some cognitive function in these HF patients. Through neuropsychological tests it was compared to 78 elderly and 37 in the control group (mean age 68.3 ± 6.3), 41 clinical group with mean age of 68.6 ± 6.9). The subjects were matched to the level of education with a predominance of elderly people with 0-4 years of education (65.9% in the Clinical Group and 59.5% in the control group). We used 11 neuropsychological tests covering the cognitive functions: attention, language, memory, mood and executive function. The results showed significant differences mainly in executive functions which include planning capacity, organization, alternation and evocation of Previously stored information. Cognitive performance in other functions was similar between the groups. The data collected when indicating cognitive impairment in individuals with HF, suggest that new studies be performed with this population since the impairments in cognitive abilities have implications in the daily life of the individual, in their independence and quality of life, as well as in adherence to treatment.
Dentre as diversas patologias que acometem os idosos destacam-se as doenças cardiovasculares, entre elas a Insuficiência Cardíaca (IC). Recentemente, busca-se verificar a existência de prejuízos cognitivos associados a prejuízos físicos e psicológicos, comumente conhecidos na IC. Analisamos uma população de pacientes com insuficiência cardíaca com o objetivo de comparar seu desempenho cognitivo com o de indivíduos com envelhecimento normal em idade pareada. Verificou-se, ainda, se havia nesses pacientes com IC algum comprometimento mais específico de alguma função cognitiva. Foram utilizados onze testes neuropsicológicos abrangendo as funções cognitivas: atenção, linguagem, memória, humor e função executiva. A amostra foi composta de 78 idosos ao total. O grupo controle foi composto de 37 indivíduos (com idade média de 68,3 ± 6,3) e o grupo clínico de 41 indivíduos (com idade média de 68,6 ± 6,9). Os sujeitos foram pareados em relação ao nível de escolaridade, com predomínio de idosos com 0 a 4 anos de estudo (65,9% no Grupo Clínico e 59,5 % no Grupo Controle). Os resultados apontaram diferenças significativas entre os grupos, principalmente nas funções executivas, que englobam capacidade de planejamento, organização, alternância e evocação da informação anteriormente armazenada. O desempenho atentivo mostrou-se alterado no que se refere à atenção alternada, bem como no que diz respeito à velocidade de processamento, tendo o grupo clínico mostrado pior desempenho nessas habilidades. A memória de curto prazo também possui pior desempenho no grupo clínico, grupo que, ademais, apresentou dificuldades na memória de longo prazo, sofrendo interferência de prejuízos executivos nessa habilidade. Os dados colhidos ao apontarem prejuízos cognitivos nos indivíduos com IC sugerem que novos estudos sejam realizados com essa população, visto que os prejuízos nas habilidades cognitivas implicam em danos no cotidiano do indivíduo, na sua independência e na qualidade de vida, bem como na adesão ao tratamento.
Sharma, Sumeet. "Thrombotic risk assessment in end stage renal disease patients on renal replacement therapy." Thesis, University of Hertfordshire, 2015. http://hdl.handle.net/2299/17114.
Повний текст джерелаZajac, Jakub. "Assessment of Ventricular Function in Normal and Failing Hearts Using 4D Flow CMR." Doctoral thesis, Linköpings universitet, Avdelningen för kardiovaskulär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-141006.
Повний текст джерелаBarbosa, Daniel. "Automated assessment of cardiac morphology and function : An integrated B-spline framework for real-time segmentation and tracking of the left ventricle." Thesis, Lyon, INSA, 2013. http://www.theses.fr/2013ISAL0111.
Повний текст джерелаThe fundamental goal of the present thesis was the development of automatic strategies for left ventricular (LV) segmentation and tracking in RT3DE data. Given the challenging nature of RT3DE data, classical computer vision algorithms often face complications when applied to ultrasound. Furthermore, the proposed solutions were formalized and built to respect the following requirements: they should allow (nearly) fully automatic analysis and their computational burden should be low, thus enabling real-time processing for optimal online clinical use. With this in mind, we have proposed a novel segmentation framework where the latest developments in level-set-based image segmentation algorithms could be straightforwardly integrated, while avoiding the heavy computational burden often associated with level-set algorithms. Furthermore, a strong validation component was included in order to assess the performance of the proposed algorithms in realistic scenarios comprising clinical data. First, the performance of the developed tools was evaluated from a global perspective, focusing on its use in clinical daily practice. Secondly, also the spatial accuracy of the estimated left ventricular boundaries was assessed. As a final step, we aimed at the integration of the developed methods in an in-house developed software suite used for research purposes. This included user-friendly solutions for efficient daily use, namely user interactive tools to adjust the segmented left ventricular boundaries
Eißler, Christoph Marcel [Verfasser], Andreas [Gutachter] Buck, Stefan [Gutachter] Störk, Takahiro [Gutachter] Higuchi, and Constantin [Gutachter] Lapa. "Assessment of the left ventricular systolic and diastolic function in rats using electrocardiogram-gated cardiac positron emission tomography / Christoph Marcel Eißler ; Gutachter: Andreas Buck, Stefan Störk, Takahiro Higuchi, Constantin Lapa." Würzburg : Universität Würzburg, 2021. http://d-nb.info/1225684900/34.
Повний текст джерелаSofronescu, Alina G. "Identification and functional assessment of the fibroblast growth factor-16 (FGF-16) promoter in cardiac myocytes." 2006. http://hdl.handle.net/1993/20872.
Повний текст джерелаLin, Chien-Chung, and 林建仲. "Motion Analysis and Assessment of Cardiac Function for Cardiac Images." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/2uhv85.
Повний текст джерела元智大學
資訊管理學系
104
This thesis proposes a series of methods in analyzing cardiac motion sequences. It is helpful to assist the cardiologist to analyze the medical images for further diagnosis. Coronary angiogram is one of the most valid methods for diagnosing the presence of coronary artery disease. Therefore, we propose a method to select the optimum phase from the image sequence. The optimum phases were selected by evaluating the correlation coefficients with minimum inconsistency of motion in the selected data. The result of the optimum image phase selection shows that the automatically determined phases yield the optimum image quality. To achieve the purpose of providing accurate information in coronary artery images, an algorithm to extract the skeletons and borders of coronary arteries in digitalized angiograms automatically is also proposed. Based on the optimum image, we develop a combination of fragment strategy and tubular enhancement to figure out the vessel structure clearly. Cardiac wall motion plays an important role in the analysis and interpretation of various kinds of cardiac diseases. However, it is difficult to find the initial contour of cardiac boundary and produce an accurate motion flow field at motion boundaries. In this study, we propose a novel and non-iterative approach to segment the boundaries in motion images based on voting processes for catheterization angiocardiography. A voting process is first used to enforce the smoothness of motion and determine an estimation of pixel velocities, motion regions and boundaries. For the purpose of locally defining a boundary tensor field, boundary estimation is combined with intensity information from the original images. Correct velocities are computed for the pixels near boundaries, as they are reassigned to different regions. Furthermore, we propose a computer aided diagnosis/detection system for cardiac motion analysis of catheterization ventriculography. The purpose of this method is to develop a computerized system which helps physicians and radiologists to automatically predict the presence of heart disease as early as possible. The adaptive ellipse active contour model is used to refine the contours. Motion analysis of cardiac are performed according to the extracted contours to form the motion vector field by Empirical Mode Decomposition (EMD) method. The results of motion detection are displayed in the formats of motion vector fields and Doppler color display. The combination of quantitative cardiac motion analysis obtained from cardiac images enable the clinician to determine whether there exists a heart disease and therefore may need treatment. The purpose of this thesis is to make use of image information to assistant the diagnosis. Experiment results show that physicians can use the proposed solid model for process of evaluation and planning before the surgeries to promote the efficiency of diagnosis, medical treatment qualities and reduce the waste of medical resource.
Yang, Shih-Yu, and 楊詩郁. "Motion Analysis and Assessment of Cardiac Function in Catheterization Ventriculography." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/04623345291203615943.
Повний текст джерела元智大學
資訊管理學系
98
This study propose a computer-aided system to provide the motion analysis and assessment of cardiac function in catheterization ventriculography. First, we use the block matching method to segment the coarse contour of left ventricular region. Then, morphological operations were used to refine the contour. Secondly, a two step fuzzy logic system was used to identify the direction of heart motion. The Doppler ultrasonography representation was used to present a more intuitive and objective interpretation of cardiac information. Finally, some of the parameters such as Ejection Fraction and slope variation of ventricular are used to evaluate the cardiac function. Experimental results show that the proposed method can provide an effective motion analysis and assessment of cardiac function in catheterization ventriculography. Meanwhile, it can be further as the computer aided diagnosis system (CAD) for differential diagnosis in the future.
Krishnamurthy, Ramkumar. "Cardiac MRI: Improved Assessment of Left Ventricular Function, Wall Motion, and Viability." Thesis, 2013. http://hdl.handle.net/1911/71979.
Повний текст джерелаLin, Kuen-You, and 林琨祐. "Assessment of the cardiac function of zebrafish and the cardiac activities of drugs with pseudo-dynamic three-dimensional imaging." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/w2jb34.
Повний текст джерела國立交通大學
應用化學系碩博士班
102
The zebrafish (Danio rerio) possesses various attractive features including rapid development, ease of genetic manipulation and low cost of maintenance, and has become a popular animal model for the study of cardiovascular diseases and for the screening of drugs with therapeutic or adverse effects. Herein, we demonstrate a novel application of pseudo-dynamic three-dimensional (3D) cardiac imaging for precise determination of the cardiac function of zebrafish. With this technique, we particularly determined individual important parameters of the cardiac function of zebrafish larvae (including ventricular stroke volume, ejection fraction, cardiac output, heart rate, diastolic filling function and ventricular mass). We compared critically the cardiac parameters obtained with our approach with those derived with conventional 2D approximation termed “fit-to-ellipse”, and show that our 3D approach is superior in several respects. To demonstrate potential applications of our approach to pharmaceutical development, we evaluated specifically the inotropic and chronotropic response of the heart of zebrafish subject to pharmacological interventions of epinephrine, esmolol and doxazosin. Our results show that zebrafish exhibited pharmacological responses to these cardioactive drugs in a way similar to human beings do. We revealed also an impaired cardiac function of a zebrafish model of cardiomyopathy induced by a treatment of doxorubicin. Given the growing interest in the application of zebrafish in both basic and applied biomedical research, we anticipate that our approach should have widespread applications in not only pharmaceutical development but also studies of cardiac development, pathophysiology or therapies targeting human heart diseases.
Couceiro, Ricardo Jorge dos Santos. "Cardiovascular Performance Assessment for p-Health Applications." Doctoral thesis, 2015. http://hdl.handle.net/10316/26987.
Повний текст джерелаAs doenças cardiovasculares (CVDs) são atualmente a principal causa de morte no mundo e são responsáveis por mais de 7 milhões de mortes todos os anos. A mortalidade decorrente das CVDs tem vindo aumentar, principalmente devido ao crescimento da população nos países de baixo e médio rendimento, que alojam cerca de 85% da população mundial. Nos países de elevado rendimento, o acesso a melhores tecnologias de diagnostico e melhores terapêuticas, bem como estilos de vida mais saudáveis, inverteram esta tendência e a mortalidade resultante das CVDs está a decrescer. Este facto, aliado ao aumento da esperança média de vida das populações, leva a que as pessoas sejam afectadas ou morram devido a CVDs em idades mais avançadas, contribuindo para o aumento dos gastos com a saúde em todo o mundo. Uma condição que contribui largamente para este problema é a síncope, que têm um impacto económico equivalente a doenças como a asma, HIV e doença pulmonar obstrutiva crónica. Mais conhecida como “desmaio”, a síncope está associada a uma frequência elevada de quedas e de hospitalizações, e é responsável por uma menor a qualidade de vida, especialmente em populações mais idosas. Para enfrentar os encargos socioeconómicos derivados das CVDs, o paradigma da saúde tem vindo a mudar de reativo e centralizado nos hospitais para preventivo e centrado em cada individuo, com um foco especial no diagnostico precoce e em melhores estratégias de prevenção e gestão das CVDs. Assim, o desenvolvimento de novas metodologias para monitorização da função cardiovascular, capazes de serem aplicadas em sistemas de baixo custo, não invasivos e portáteis, são essenciais para a prevenção e controlo desta crescente epidemia que são as CVDs. Apesar dos recentes avanços tecnológicos, as técnicas padrão atuais para a avaliação da função cardiovascular, como a ressonância magnética cardíaca e ecocardiografia, ainda apresentam várias limitações no que diz respeito à sua aplicação em ambientes de saúde personalizada. Assim, a utilização de modalidades amplamente disponíveis e de baixo custo, como o eletrocardiograma e o fotopletismograma, para a avaliação não-invasiva, contínua e de longo prazo da função cardiovascular pode ser a chave para melhores estratégias de prevenção e gestão de doenças cardiovasculares. Mais concretamente, a extração de parâmetros cardiovasculares a partir destas modalidades pode ser crucial na predição de síncopes e prevenção de quedas. A principal contribuição da presente tese consiste no desenvolvimento de novos algoritmos para a avaliação continua, não invasiva e robusta da função cardiovascular, com base na análise do eletrocardiograma e do fotopletismograma. Visto que o fotopletismograma é facilmente afectado por ruído e artefactos de movimento, o que representa um obstáculo para a extração de parâmetros cardiovasculares, é fundamental detectar quais as secções do fotopletismograma passiveis de serem posteriormente analisadas. Assim, propomos um novo método para detecção de artefactos de movimento baseado na extração e análise de características do domínio temporal e de período. Consequentemente, propomos um novo algoritmo para a estimação do tempo de ejecção do ventrículo esquerdo, o qual está associado com a função cardíaca, bem como outros parâmetros relacionados com alterações de pressão sanguínea e de tónus vascular. Finalmente, propomos um novo algoritmo para a predição de síncopes (mais especificamente, síncope neuromediada) baseada na avaliação dos parâmetros previamente extraídos. Os métodos propostos foram validados em três bases de dados, coligidas no Departamento de Engenharia Informática da Universidade de Coimbra, no Centro Hospitalar da Universidade de Coimbra e no departamento de Eletrofisiologia do Centro Universitário do Coração, Hospital Universitário de Eppendorf, Hamburgo, Alemanha.
Cardiovascular diseases (CVDs) are currently the leading cause of death in the world and are responsible for over 17 million deaths per year. The mortality of CVDs is increasing, mainly driven by the increase of the population in low and middle income countries, which house about 85% of the world’s population. In high-income countries, the access to better diagnostic and therapeutic technologies, as well as healthier life stiles, reverses this tendency and CVD mortality is decreasing. In combination with the increase in the populations’ life expectancy, people are affected or die as a result of CVD at older ages, contributing to the rise in the health care expenditures all over the world. A condition largely contributing to this matter is syncope, which has an economic impact equivalent to conditions such as asthma, HIV, and chronic obstructive pulmonary disease. More commonly known as fainting, syncope is associated with high rate of falls and hospitalization and is responsible for reducing lifestyle quality, especially in the elderly. To face this socioeconomic burden caused by CVDs, the health care paradigm is shifting from a reactive hospital-centered to a preventive individual-centered care, with special emphasis in earlier diagnosis and better prevention and management strategies. Therefore, the development of new methodologies for monitoring the cardiovascular function, capable of being applied in low-cost, non-invasive and portable systems, are essential to prevent and control the evolving epidemic of CVDs. Despite the recent technological advances, the current standard techniques for the assessment of cardiovascular function, such as the cardiac magnetic resonance and echocardiography, still exhibit several limitations in what concerns to their application in personal health environments. Therefore, the use of widely available and cost-effective modalities such as the electrocardiogram and photoplethysmogram, for the non-invasive, continuous and long-term assessment of the cardiovascular function may be the key to provide a better prevention and management strategies of CVDs. More specifically, the extraction of cardiovascular parameters from these modalities may be crucial in the prediction of syncope events and prevention of falls. The key contribution of the present thesis is the development of new algorithms for the continuous, non-invasive and robust assessment of cardiovascular function, based on the analysis of the electrocardiogram and photoplethysmogram. Since the photoplethysmogram is easily influenced by noise and motion artifacts, which can be a serious obstacle in the extraction of cardiovascular parameters, it is essential to detect which sections of the photoplethysmogram are liable for further analysis. Therefore, we propose a new method for the detection of motion artifacts, based on the extraction and analysis of time and period domain features. Consequently, we propose a new algorithm for the assessment of the left ventricular ejection time, which is associated with the cardiac function, among other parameters related with blood pressure and vascular tones changes. Finally, we propose a new algorithm for the prediction of syncope events (more specifically, neurally mediated syncope), based on the evaluation of changes in the previously extracted cardiovascular parameters. The proposed methods were validated in three databases collected in the Department of Informatics Engineering of the University of Coimbra, in the Hospital Center of University of Coimbra and in the Department of Electrophysiology of the University Heart Center, University Hospital Eppendorf, Hamburg, Germany.
Molaee, Payman. "Assessment of left atrial structure and function in the setting of atrial fibrillation using cardiac magnetic resonance imaging." Thesis, 2012. http://hdl.handle.net/2440/76646.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2012
Lin, Shih-Hsuan, and 林士軒. "Assessment of Left Ventricular Function after Parachute Device Implantation in Patients with Ischemia Heart Failure using Cardiac CT." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/53634533161629252676.
Повний текст джерела國立陽明大學
生物醫學影像暨放射科學系
103
Background Left ventricular (LV) remodeling after (MI) is characterized by progressive LV dilatation, which if left untreated, may ultimately result in progressive systolic dysfunction, LV aneurysm formation, heart failure and death. Recently, an implantable novel percutaneous device had been developed, aiming for proper isolation of the dysfunctional region of the LV in order to reduce both LV volume and attenuate myocardial wall stress. This study aimed to evaluate whether Parachute LV partitioning system implantation improved LV diastolic function assessed by MDCT. Material and methods Twenty eight patients who had cardiac CT images before and 6 months after Parachute device implantation, and twenty eight subjects with normal cardiac CT images were included in this retrospective study. The cardiac functional indexes including left ventricle length, end-diastolic and end-systolic volume as well as systolic function and diastolic function were analyzed by off-line analysis (TeraRecon Aquarius workstation, San Mateo, Calif). The normal group is for the validation of the value of cardiac functional indexes. Result The comparison of LV structure variables between baseline, 6 months follow up groups showed a significantly decrease in LV length, LV end-systolic volume, and LV end-diastolic volume; LV systolic function indexes shows a significantly improved in LV ejection fraction (LVEF) (0.31 ± 0.10 vs. 0.35 ± 0.10, respectively, p < 0.01), but there were no significant difference in stroke volume (78.71 ± 24.82 ml vs. 78.07 ± 20.60 ml, respectively, p = NS); LV diastolic function parameters showed a significantly improved in E/Ea (21.96 ± 15.58 ml vs. 13.55 ± 9.86, respectively, p < 0.01), but no significant difference in E/A (2.23 ± 2.09 vs. 2.16 ± 1.56, respectively, p = NS). The result of normal group showed the minimum LV length, LV end-systolic volume, LV end-diastolic volume among the three groups, and LVEF, LV diastolic function parameters which were E/Ea, E/A were all in the normal range (0.73±0.08, 3.70±2.22, 1.36±0.51, respectively). Discussion and conclusion This study successfully used cardiac CT images to evaluate these cardiac functional indexes, and the results which in the normal range of normal group were ensured the accuracy of CT measurement. A significant decrease in LV structure and improvement in both systolic and diastolic function occurred after device implantation showed a potential beneficial effect of this novel device in treatment of LV aneurysm.
Eißler, Christoph Marcel. "Assessment of the left ventricular systolic and diastolic function in rats using electrocardiogram-gated cardiac positron emission tomography." Doctoral thesis, 2021. https://doi.org/10.25972/OPUS-21976.
Повний текст джерелаDie DD ist eine Störung der Herzdynamik, welche, aufgrund ihrer Beteiligung in verschiedenen Herzerkrankungen und Kardiomyopathien wie der ischämischen Kardiomyopathie, der arteriellen Hypertonie und der diabetischen Kardiomyopathie, in den letzten Jahren zunehmend in das Interessenzentrum der Herzforschung gerückt ist. Die EKG-getriggerte 18F-FDG PET ist eine Bildgebungsmethode, welche die Unterscheidung von vitalem Myokard und Narben ermöglicht und zusätzlich noch in der Lage ist, wichtige Informationen zu erheben, welche von Bedeutung für die Beurteilung von experimentelle Behandlungen zur Verbesserung der Herzfunktion und/oder des kardialen Stoffwechsels in präklinischen Tiermodellen sind. Trotz dieser Möglichkeiten wurde bisher noch nicht die Fähigkeit der EKG-getriggerten 18F-FDG PET zur Bestimmung der LV diastoischen Funktion in Kleintiermodellen untersucht. Deshalb wurde in dieser Arbeit das Potential der EKG-getriggerten 18F-FDG PET in Bezug auf die Bestimmung der LV systolischen und diastolischen Funktion in acht Kontrollratten (ZL) und sieben ZDF-Ratten, welche eine experimentelles Tiermodell für T2DM und die damit verbundenen Komplikationen einschließlich der diabetischen Kardiomyopathie sind, untersucht. Die EKG-getriggerte 18F-FDG PET wurde unter der hyperinsulinämischen euglykämischen Klemm Methode durchgeführt, die Daten in „list-mode“ Dateien gespeichert und retrospektiv rekonstruiert. Die Berechnung der LV systolischen und diastolischen Parameter erfolge aus der Zeit-Volumen-Kurve und der Zeit-Füllungs-Kurve durch das Programm HFV. Zudem wurde der Einfluss der pro Rekonstruktion verwendeten „frames“ pro kardialen Zyklus auf die LV Volumina und die linksventrikulären Funktionsparameter untersucht. Durch die hyperinsulinämische euglykämische Klemm Methode und durch Blutglukose Messungen konnte die Entwicklung eines manifesten Diabetes zum Zeitpunkt der Experimente in den ZDF Ratten nachgewiesen werden. Es konnte kein signifikanter Unterschied zwischen den systolischen Parametern der ZDF und der ZL Ratten gefunden werden. Der kardiale Auswurf war nahezu identisch in den beiden Gruppen zum Zeitpunkt der Experimente, was eine vergleichbare systolische Funktion in beiden Gruppen demonstriert. Die erhobenen Werte für die systolischen Parameter befinden sich in guter Übereinstimmung mit den Werten der Literatur von vorherigen PET, MRT und Katheter-gestützten Experimenten in diabetischen Rattenmodellen. Ein wichtiges Ergebnis dieser Arbeit ist die Erhebung von verlässlichen diastolischen Parametern durch den kombinierten Einsatz von EKG-getriggerter 18F-FDG PET und HFV. Zudem war es möglich, eine gestörte diastolische Füllung des LV in den ZDF Ratten nachzuweisen, in Abwesenheit von systolischen Funktionseinschränkungen. Eine Beeinträchtigung der diastolischen Funktion in der frühen Phase des Diabetes wurde bereits in anderen Rattenstudien mittels Echokardiografie und Katheter basierten Untersuchungen gezeigt. Dennoch ist dies hier die erste Studie, welche demonstriert, dass die Bestimmung der diastolischen Funktion auch mit Hilfe der EKG-getriggerten 18F-FDG PET durchgeführt werden kann. In Zusammenfassung lässt sich festhalten, das zusätzlich zu der Bestimmung der LV-Volumina und der LVEF durch EKG-getriggerten 18F-FDG PET auch die Bestimmung der diastolischen Funktion in gesunden und diabetischen Ratten möglich ist und dass durch EKG-getriggerten 18F-FDG PET die Identifikation einer DD in ZDF Ratten möglich ist
Azevedo, Ana Catarina Soares Feio de. "Pressure-wire based functional assessment of coronary stenoses in surgical heart valve disease patients: impact in the coronary revascularization technique." Master's thesis, 2019. http://hdl.handle.net/10316/89728.
Повний текст джерелаObjetivos: Descrever de que forma a informação obtida pela realização de avaliação funcional por guia de pressão afetou a estratégia de revascularização cirúrgica das artérias estudadas e realizar o seguimento clínico, a um ano, em termos de eventos cardio e cerebrovasculares: morte cardiovascular, enfarte agudo do miocárdio e revascularização não planeada.Métodos: Foi conduzida uma análise retrospetiva de um coorte prospetivo de 32 doentes com doença valvular cardíaca, de um grupo de 298 doentes submetidos a uma avaliação funcional de estenoses coronárias intermédias por guia de pressão no nosso centro entre outubro de 2013 e fevereiro de 2018. As características dos doentes foram retiradas de duas bases de dados. O tempo médio de seguimento clínico foi de 421 dias. Na análise dos dados usaram- se como valores de referência de FFR e IFR um cut-off de ≤0,80 e de ≤0,89, respetivamente.Resultados: Neste estudo foram incluídos 32 doentes com doença valvular cardíaca com indicação cirúrgica, tendo sido avaliadas através do FFR e/ou iFR 42 lesões coronárias. Foram integrados 23 doentes do sexo masculino e a idade média foi de 73 anos. Relativamente aos fatores de risco para doença cardiovascular, 81,3% dos doentes tinham hipertensão, 81,3% eram dislipidémicos, 31,3% tinham diabetes mellitus e 18,8% eram fumadores. A descendente anterior foi a artéria coronária mais vezes envolvida, afetando 23 (54,8%) doentes. Apenas 9 lesões foram classificadas como sendo hemodinamicamente significativas e 6 dessas foram revascularizadas. As 33 lesões restantes não tinham indicação para serem tratadas, no entanto 1 lesão foi revascularizada cirurgicamente.Conclusão: No nosso centro os cirurgiões cardíacos acreditam e atuam consoante os resultados da avaliação funcional. Após um ano de seguimento clínico não se registaram eventos cardiovasculares major nos doentes cuja avaliação funcional tinha sido negativa, confirmando a segurança da utilização do FFR e iFR nesta população com doença valvular grave.
Aims: Describe how the pressure-wire based functional assessment of intermediate coronary stenoses affected the strategy of myocardial revascularization and to perform a one-year analysis in terms of cardiovascular events: cardiovascular death, myocardial infarction and unplanned revascularization.Methods: We conducted a retrospective analysis on a prospective cohort of 32 patients with valvular heart disease out of 298 patients who underwent a pressure-wire based functional assessment of coronary stenosis between October 2013 and February 2018. The baseline data were extracted from two main databases. The median follow-up was 421 days. The cut- off values of 0.80 and 0.89 were used for FFR and iFR, respectively.Results: We included 32 patients with valvular heart disease, which of 42 coronary lesions were functionally assessed by FFR and/or IFR. There were 23 male and 9 female patients and the median age was 73 (66.0-78.0) years. Regarding risk factors for cardiovascular diseases, 81.3% of the patients had hypertension, 81.3% were dyslipidemic, 18.8% were smokers and 31.3% were diabetic. The most frequent lesion was on the left anterior descending coronary artery, affecting 23 (54.8%) patients. Only 9 lesions were classified as hemodynamically significant and 6 of them were treated, either by PCI or CABG. The 33 remaining lesions didn’t have an indication for revascularization, however, one lesion was treated with CABG. There were no major cardiovascular events within 12 months of follow-up.Conclusion: In our centre, the cardiothoracic surgeons believe and act accordingly to the functional assessment evaluation of the coronary lesions. During the follow-up time, no cardiovascular events were registered among the patients which coronary physiological measurements were negative, confirming the safe use of FFR or iFR in this population with valvular heart disease.