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Автор: Grafiati
Опубліковано: 7 липня 2024

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1

Yambe, T., S. Nanka, S. Kobayashi, N. Owada, A. Ozoe, A. Miyakawa, S. Konno, et al. "NONLINEAR ANALYSIS OF CARDIAC CONTRACTION TO EVALUATE THE CARDIAC FUNCTION." ASAIO Journal 45, no. 2 (March 1999): 146. http://dx.doi.org/10.1097/00002480-199903000-00107.

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2

Guttman, M. A., E. A. Zerhouni, and E. R. McVeigh. "Analysis of cardiac function from MR images." IEEE Computer Graphics and Applications 17, no. 1 (January 1997): 30–38. http://dx.doi.org/10.1109/38.576854.

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3

SEI, Tetsurou. "Quantitative analysis of cardiac function using cine MR." Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 106, no. 1-2 (1994): 163–71. http://dx.doi.org/10.4044/joma1947.106.1-2_163.

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4

Araki, Junichi, Hiromi Matsubara, Juichiro Shimizu, Takeshi Mikane, Satoshi Mohri, Ju Mizuno, Miyako Takaki, Tohru Ohe, Masahisa Hirakawa, and Hiroyuki Suga. "Weibull distribution function for cardiac contraction: integrative analysis." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 5 (November 1, 1999): H1940—H1945. http://dx.doi.org/10.1152/ajpheart.1999.277.5.h1940.

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The Weibull distribution is widely used to analyze the cumulative loss of performance, i.e., breakdown, of a complex system in systems engineering. We found for the first time that the difference curve of two Weibull distribution functions almost identically fitted the isovolumically contracting left ventricular (LV) pressure-time curve [P( t)] in all 345 beats (3 beats at each of 5 volumes in 23 canine hearts; r = 0.999953 ± 0.000027; mean ± SD). The first derivative of the difference curve also closely fitted the first derivative of the P( t) curve. These results suggest the possibility that the LV isovolumic P( t) curve may be characterized by two counteracting cumulative breakdown systems. Of these, the first breakdown system causes a gradual pressure rise and the second breakdown system causes a gradual pressure fall. This Weibull-function model of the heart seems to give a new systems engineering or integrative physiological view of the logic underlying LV isovolumic pressure generation.
5

ROBERTS, N., L. M. CRUZ‐ORIVE, M. BOURNE, R. J. HERFKENS, R. A. KARWOSKI, and G. H. WHITEHOUSE. "Analysis of cardiac function by MRI and stereology." Journal of Microscopy 187, no. 1 (July 1997): 31–42. http://dx.doi.org/10.1046/j.1365-2818.1997.2040764.x.

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6

Hunter, P. J., and B. H. Smaill. "The analysis of cardiac function: A continuum approach." Progress in Biophysics and Molecular Biology 52, no. 2 (January 1988): 101–64. http://dx.doi.org/10.1016/0079-6107(88)90004-1.

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7

Gajewski, K., N. Fossett, J. D. Molkentin, and R. A. Schulz. "The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila." Development 126, no. 24 (December 15, 1999): 5679–88. http://dx.doi.org/10.1242/dev.126.24.5679.

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The regulation of cardiac gene expression by GATA zinc finger transcription factors is well documented in vertebrates. However, genetic studies in mice have failed to demonstrate a function for these proteins in cardiomyocyte specification. In Drosophila, the existence of a cardiogenic GATA factor has been implicated through the analysis of a cardial cell enhancer of the muscle differentiation gene D-mef2. We show that the GATA gene pannier is expressed in the dorsal mesoderm and required for cardial cell formation while repressing a pericardial cell fate. Ectopic expression of Pannier results in cardial cell overproduction, while co-expression of Pannier and the homeodomain protein Tinman synergistically activate cardiac gene expression and induce cardial cells. The related GATA4 protein of mice likewise functions as a cardiogenic factor in Drosophila, demonstrating an evolutionarily conserved function between Pannier and GATA4 in heart development.
8

Snelling, Edward P., Roger S. Seymour, J. E. F. Green, Leith C. R. Meyer, Andrea Fuller, Anna Haw, Duncan Mitchell, et al. "A structure-function analysis of the left ventricle." Journal of Applied Physiology 121, no. 4 (October 1, 2016): 900–909. http://dx.doi.org/10.1152/japplphysiol.00435.2016.

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This study presents a structure-function analysis of the mammalian left ventricle and examines the performance of the cardiac capillary network, mitochondria, and myofibrils at rest and during simulated heavy exercise. Left ventricular external mechanical work rate was calculated from cardiac output and systemic mean arterial blood pressure in resting sheep ( Ovis aries; n = 4) and goats ( Capra hircus; n = 4) under mild sedation, followed by perfusion-fixation of the left ventricle and quantification of the cardiac capillary-tissue geometry and cardiomyocyte ultrastructure. The investigation was then extended to heavy exercise by increasing cardiac work according to published hemodynamics of sheep and goats performing sustained treadmill exercise. Left ventricular work rate averaged 0.017 W/cm3 of tissue at rest and was estimated to increase to ∼0.060 W/cm3 during heavy exercise. According to an oxygen transport model we applied to the left ventricular tissue, we predicted that oxygen consumption increases from 195 nmol O2·s−1·cm−3 of tissue at rest to ∼600 nmol O2·s−1·cm−3 during heavy exercise, which is within 90% of the oxygen demand rate and consistent with work remaining predominantly aerobic. Mitochondria represent 21-22% of cardiomyocyte volume and consume oxygen at a rate of 1,150 nmol O2·s−1·cm−3 of mitochondria at rest and ∼3,600 nmol O2·s−1·cm−3 during heavy exercise, which is within 80% of maximum in vitro rates and consistent with mitochondria operating near their functional limits. Myofibrils represent 65–66% of cardiomyocyte volume, and according to a Laplacian model of the left ventricular chamber, generate peak fiber tensions in the range of 50 to 70 kPa at rest and during heavy exercise, which is less than maximum tension of isolated cardiac tissue (120–140 kPa) and is explained by an apparent reserve capacity for tension development built into the left ventricle.
9

Cingolani, Oscar H., and David A. Kass. "Pressure-volume relation analysis of mouse ventricular function." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 6 (December 2011): H2198—H2206. http://dx.doi.org/10.1152/ajpheart.00781.2011.

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Nearly 40 years ago, the Sagawa laboratory spawned a renaissance in the use of instantaneous ventricular pressure-volume (P-V) relations to assess cardiac function. Since then, this analysis has taken hold as the most comprehensive way to quantify ventricular chamber function and energetics and cardiovascular interactions. First studied in large mammalian hearts and later in humans employing a catheter-based method, P-V analysis was translated to small rodents in the late 1990s by the Kass laboratory. Over the past decade, this approach has become a gold standard for comprehensive examination of in vivo cardiac function in mice, facilitating a new era of molecular cardiac physiology. The catheter-based method remains the most widely used approach in mice. In this brief review, we discuss this instrumentation, the theory behind its use, and how volume signals are calibrated and discuss elements of P-V analysis. The goal is to provide a convenient summary of earlier investigations and insights for users whose primary interests lie in genetic/molecular studies rather than in biomedical engineering.
10

Yuasa, Toshinori, Mihoko Kouno, Akira Kisanuki, Nami Ueya, Kenichi Nakashiki, Eiji Kuwahara, Kayoko Kubota, Naoko Mizukami, Kunitsugu Takasaki, and Chuwa Tei. "Assessment of Cardiac Function and Heart Failure by Cardiac Time Analysis (Tei Index)." Journal of Cardiac Failure 15, no. 7 (September 2009): S138. http://dx.doi.org/10.1016/j.cardfail.2009.07.219.

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11

Yambe, Tomoyuki, Shun‐suke Nanka, Shin‐ichi Kobayashi, Akira Tanaka, Naoki Owada, Makoto Yoshizawa, Ken‐ichi Abe, et al. "Detection of the Cardiac Function by Fractal Dimension Analysis." Artificial Organs 23, no. 8 (August 1999): 751–56. http://dx.doi.org/10.1046/j.1525-1594.1999.06416.x.

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12

Boudraa, A. O., J. Champier, M. Djebali, F. Behloul, and A. Beghdadi. "Analysis of dynamic nuclear cardiac images by covariance function." Computerized Medical Imaging and Graphics 23, no. 4 (July 1999): 181–91. http://dx.doi.org/10.1016/s0895-6111(99)00017-8.

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13

Berglund, J. E., E. Haldén, S. Jakobson, and J. Landelius. "Echocardiographic analysis of cardiac function during high PEEP ventilation." Intensive Care Medicine 20, no. 3 (March 1994): 174–80. http://dx.doi.org/10.1007/bf01704696.

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14

Renner, Jochen, Jens Scholz, and Berthold Bein. "Monitoring cardiac function: Echocardiography, pulse contour analysis and beyond." Best Practice & Research Clinical Anaesthesiology 27, no. 2 (June 2013): 187–200. http://dx.doi.org/10.1016/j.bpa.2013.06.005.

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15

Kao, Yi-Hsuan, Wan-Yuo Guo, Adrain Jy-Kang Liou, Ting-Yi Chen, Chau-Chiun Huang, Chih-Che Chou, and Jiing-Feng Lirng. "Transfer Function Analysis of Respiratory and Cardiac Pulsations in Human Brain Observed on Dynamic Magnetic Resonance Images." Computational and Mathematical Methods in Medicine 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/157040.

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Magnetic resonance (MR) imaging provides a noninvasive,in vivoimaging technique for studying respiratory and cardiac pulsations in human brains, because these pulsations can be recorded as flow-related enhancement on dynamic MR images. By applying independent component analysis to dynamic MR images, respiratory and cardiac pulsations were observed. Using the signal-time curves of these pulsations as reference functions, the magnitude and phase of the transfer function were calculated on a pixel-by-pixel basis. The calculated magnitude and phase represented the amplitude change and temporal delay at each pixel as compared with the reference functions. In the transfer function analysis, near constant phases were found at the respiratory and cardiac frequency bands, indicating the existence of phase delay relative to the reference functions. In analyzing the dynamic MR images using the transfer function analysis, we found the following: (1) a good delineation of temporal delay of these pulsations can be achieved; (2) respiratory pulsation exists in the ventricular and cortical cerebrospinal fluid; (3) cardiac pulsation exists in the ventricular cerebrospinal fluid and intracranial vessels; and (4) a 180-degree phase delay or inverted amplitude is observed on phase images.
16

Bechri, Ibrahim, Ali Derkaoui, Abdelkarim Shimi, and Mohammed Khatouf. "Low cardiac output syndrome after cardiac surgery: A retrospective analysis." INTERNATIONAL JOURNAL OF MEDICINE AND MEDICAL RESEARCH 9, no. 1 (April 28, 2023): 6–14. http://dx.doi.org/10.61751/ijmmr.2413-6077.2023.1.06.

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Low cardiac output syndrome is a prevalent complication observed after cardiac surgery, related to elevated rates of mortality and morbidity. The study aimed to pinpoint independent risk factors for low cardiac output through the analysis of post-cardiac surgery data. This is a single-centre, two-year retrospective study from January 2021 to December 2022, including all patients admitted to the A1 general intensive care unit for postoperative management of cardiac surgery. Variables from preoperative, intraoperative, and postoperative data were collected and evaluated with the statistical package for the social sciences, with a significance level set at p < 0.05. Overall, the median age was 44 years (22-80), with 60% being female. The prevalence of low cardiac output syndrome after cardiac surgery was 44% (n = 85). Significant risk factors for low cardiac output syndrome were identified: low preoperative left ventricular function (ejection fraction <40%), preoperative atrial fibrillation, impaired preoperative renal function, multiple valve replacement, prolonged extracorporeal circulation, and clamping time. Patients who experienced low cardiac output syndrome had longer hospital stays and a higher incidence of postoperative complications, including atrial fibrillation and kidney injury, as well as a higher mortality rate (7% versus 0%). Identification and treatment of low cardiac output syndrome can improve myocardial recovery and decrease mortality. A better understanding of its physiopathological mechanisms may help develop potential preventive strategies
17

Magder, S. "Theoretical analysis of the noncardiac limits to maximum exercise." Canadian Journal of Physiology and Pharmacology 80, no. 10 (October 1, 2002): 971–79. http://dx.doi.org/10.1139/y02-119.

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When right atrial pressure (Pra) is greater than zero (atmospheric pressure), cardiac output is determined by the intersection of two functions, cardiac function and return function, which is used here to mean the determinants of venous return. When Pra [Formula: see text] 0, flow is only determined by circuit function. The objective of this analysis was to determine the potential changes in return function that need to occur to allow the maximum cardiac output during exercise when Pra [Formula: see text] 0 or is constant. The analysis expands on the model of Green and Jackman and includes the effects of changes in circuit parameters, including venous resistance, changes in capacitance, and muscle contractions. The analysis is based on the model of the circulation proposed by Permutt and co-workers, which assumes that the systemic circulation has two lumped compliant regions in parallel with independent inflow and outflow resistances. Changes in total flow in this model can come about by changes in the distribution of flow between the regions, recruitment of unstressed vascular volume, and changes in the regional venous resistances. The data for the analysis are from previous animal studies and are normalized to a 70-kg man. The major conclusions are that, to achieve the high cardiac output that occurs at peak exercise, there need to be marked changes in the distribution of blood flow, recruitment of unstressed volume, and the venous resistance draining vascular beds. A consequence of the increase in peripheral flow is a marked increase in pressure in the veins of the working muscle. Muscle contractions are potentially a very important mechanism for transiently decreasing this pressure and preventing excessive filtration of plasma during exercise.Key words: cardiac output, venous return, muscle contractions.
18

Chang, Pan, Shengping Lei, Xiaomeng Zhang, Jing Zhang, Xihui Wang, Juan Wu, Jianbang Wang, Jianping Geng, Baoying Chen, and Jun Yu. "Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance." Cardiology Research and Practice 2020 (December 9, 2020): 1–11. http://dx.doi.org/10.1155/2020/1416945.

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Brain natriuretic peptide (BNP) is an important biological marker and regulator of cardiac function. BNP resistance is characterized by high concentrations of less functionally effective BNP and common in heart failure (HF) patients. However, the roles and consequences of BNP resistance remain poorly understood. Investigate the effects of cardiac BNP resistance and identify potential metabolic biomarkers for screening and diagnosis. Thirty patients and thirty healthy subjects were enrolled in this study. Cardiac functions were evaluated by echocardiography. The plasma levels of cyclic guanosine monophosphate (cGMP) and BNP were measured by enzyme-linked immunosorbent assay (ELISA) and the cGMP/BNP ratio is calculated to determine cardiac natriuretic peptide resistance. Liquid chromatograph tandem mass spectrometry (LC-MS) based untargeted metabolomics analysis was applied to screen metabolic changes. The cGMP/BNP ratio was markedly lower in HF patients than controls. The cGMP/BNP ratio and ejection fraction (EF) were strongly correlated (R2 = 0.676, P < 0.05 ). Importantly, metabolic profiles were substantially different between HF patients and healthy controls. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that the differentially expressed metabolites are involved in signaling pathways that regulate cardiac functions. In HF patients, BNP resistance develops in association with a reduction in heart function and metabolic remodeling. It suggests possible functional roles of BNP resistance in the regulation of cardiac metabolism.
19

Chiba, Yoshihide, Hideki Kobayashi, Toru Kanzaki, and Masayoshi Murakami. "Quantitative Analysis of Cardiac Function in Non-Immunological Hydrops fetalis." Fetal Diagnosis and Therapy 5, no. 3-4 (1990): 175–88. http://dx.doi.org/10.1159/000263590.

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20

TSUTSUMI, Masakazu, Tadashi INABA, Yutaka SAWAKI, and Masataka TOKUDA. "Finite Element Analysis of Cardiac Function in Hypertensive Heart Disease." Proceedings of The Computational Mechanics Conference 2003.16 (2003): 303–4. http://dx.doi.org/10.1299/jsmecmd.2003.16.303.

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21

Sanches, Pedro Gomes, Roel C. op ‘t Veld, Wolter de Graaf, Gustav J. Strijkers, and Holger Grüll. "Novel axolotl cardiac function analysis method using magnetic resonance imaging." PLOS ONE 12, no. 8 (August 24, 2017): e0183446. http://dx.doi.org/10.1371/journal.pone.0183446.

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22

Iulianella, Angelo, and David Lohnes. "Chimeric Analysis of Retinoic Acid Receptor Function during Cardiac Looping." Developmental Biology 247, no. 1 (July 2002): 62–75. http://dx.doi.org/10.1006/dbio.2002.0685.

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23

Zhang, Li, Xuejun Wang, Mengwen Feng, Hao Zhang, Jia Xu, Jingjing Ding, Zijie Cheng, and Lingmei Qian. "Peptidomics Analysis Reveals Peptide PDCryab1 Inhibits Doxorubicin-Induced Cardiotoxicity." Oxidative Medicine and Cellular Longevity 2020 (October 13, 2020): 1–23. http://dx.doi.org/10.1155/2020/7182428.

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Doxorubicin (DOX) is limited due to dose-dependent cardiotoxicity. Peptidomics is an emerging field of proteomics that has attracted much attention because it can be used to study the composition and content of endogenous peptides in various organisms. Endogenous peptides participate in various biological processes and are important sources of candidates for drug development. To explore peptide changes related to DOX-induced cardiotoxicity and to find peptides with cardioprotective function, we compared the expression profiles of peptides in the hearts of DOX-treated and control mice by mass spectrometry. The results showed that 236 differential peptides were identified upon DOX treatment, of which 22 were upregulated and 214 were downregulated. Next, we predicted that 31 peptides may have cardioprotective function by conducting bioinformatics analysis on the domains of each precursor protein, the predicted score of peptide biological activity, and the correlation of each peptide with cardiac events. Finally, we verified that a peptide (SPFYLRPPSF) from Cryab can inhibit cardiomyocyte apoptosis, reduce the production of reactive oxygen species, improve cardiac function, and ameliorate myocardial fibrosis in vitro and vivo. In conclusion, our results showed that the expression profiles of peptides in cardiac tissue change significantly upon DOX treatment and that these differentially expressed peptides have potential cardioprotective functions. Our study suggests a new direction for the treatment of DOX-induced cardiotoxicity.
24

Huang, Q. Q., H. Z. Feng, J. Liu, J. Du, L. B. Stull, C. S. Moravec, X. Huang, and J. P. Jin. "Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function." American Journal of Physiology-Cell Physiology 294, no. 1 (January 2008): C213—C222. http://dx.doi.org/10.1152/ajpcell.00146.2007.

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In contrast to skeletal muscles that simultaneously express multiple troponin T (TnT) isoforms, normal adult human cardiac muscle contains a single isoform of cardiac TnT. To understand the significance of myocardial TnT homogeneity, we examined the effect of TnT heterogeneity on heart function. Transgenic mouse hearts overexpressing a fast skeletal muscle TnT together with the endogenous cardiac TnT was investigated in vivo and ex vivo as an experimental system of concurrent presence of two classes of TnT in the adult cardiac muscle.This model of myocardial TnT heterogeneity produced pathogenic phenotypes: echocardiograph imaging detected age-progressive reductions of cardiac function; in vivo left ventricular pressure analysis showed decreased myocardial contractility; ex vivo analysis of isolated working heart preparations confirmed an intrinsic decrease of cardiac function in the absence of neurohumoral influence. The transgenic mice also showed chronic myocardial hypertrophy and degeneration. The dominantly negative effects of introducing a fast TnT into the cardiac thin filaments to produce two classes of Ca2+ regulatory units in the adult myocardium suggest that TnT heterogeneity decreases contractile function by disrupting the synchronized action during ventricular contraction that is normally activated as an electrophysiological syncytium.
25

Wysokinska, Ewa M., Katherine M. Duello, Dong Chen, and Joseph L. Blackshear. "Evaluation of Prosthetic Valve Function by Platelet Function Analysis and Von Willebrand Factor Indices." Blood 120, no. 21 (November 16, 2012): 1128. http://dx.doi.org/10.1182/blood.v120.21.1128.1128.

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Abstract Abstract 1128 Background Dysfunctional or mismatched prosthetic heart valves can results in high shear stress related von Willebrand factor (VWF) impairment, and clinical bleeding. This mechanism is similar to that seen in aortic stenosis patients, where gastrointestinal bleeding related to VWF multimer loss is well described (Heyde syndrome). In this study, we compared the results of VWF testing of patients with normally functioning cardiac valve prostheses, dysfunctional prosthetic valves, severe native aortic stenosis, and normal controls. Methods A total of 75 patients, 31 female and 44 male with a median age of 79.5 years were recruited to this study. Thirty patients had severe aortic stenosis (mean gradient > 40 mm Hg); 39 patients had normally functioning prosthetic valves, 21 aortic (AVR) and 18 mitral valves (MVR); and 6 patients had with dysfunctional valves (4 aortic and 2 mitral). Whole blood and plasma samples were drawn from patients and tested for platelet function analyzer-100 collagen ADP closure time (PFA-CADP), VWF antigen (VWF:Ag), VWF activity by latex immunoassay (VWF:Ltx), VWF multimer analysis and VWF multimer densitometry ratio of large vs medium to low molecular weight multimers (>15 mers/2–15 mers). Results The 6 dysfunctional prosthetic valve patients included patient-prosthesis mismatch (2) and (one each), thrombosed mechanical aortic prosthesis, torn biological aortic prosthesis, severe tissue mitral prosthetic regurgitation, and post-mitral valve repair severe mitral regurgitation. Four of six patients had clinically significant bleeding. Most aortic stenosis and all 6 prosthetic dysfunction patients had abnormal VWF multimers which is rare in normally functioning prostheses and completely absent in normal donors. VWF:Ltx/Ag was lower in AS and MVR than normal. VWF:Ltx/Ag ratio, VWF:multimer ratio and PFA-CADP were all significantly abnormal in patients with dysfunctional prosthetic valve. VWF:multimer ratios in normally functioning prostheses tended to be intermediate between normals and than those of patients with severe AS or prosthetic valve dysfunction (Table). Conclusions VWF testing including quantitative von Willebrand multimer analysis and PFA-CADP reliably separate dysfunctional from normally functioning cardiac prostheses, and should be considered in the evaluation of patients with cardiac prostheses, especially those who have clinically significant bleeding. Disclosures: No relevant conflicts of interest to declare.
26

Heinen, Charlotte, Karin Fijnvandraat, Marjolein Peters, Henriette Heijboer, Nico Blom, and Irene Kuipers. "Heart Function Disorders In Sickle Cell Disease." Blood 116, no. 21 (November 19, 2010): 4815. http://dx.doi.org/10.1182/blood.v116.21.4815.4815.

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Abstract Abstract 4815 Abstract Background: Sickle cell disease (SCD) is a hereditary anemia characterized by chronic hemolytic anemia and vaso-occlusive episodes, associated with a high susceptibility for infections and damage to all vital organs. Cardiologic effects of SCD are dilatation and hypertrophy of the left ventricle and pulmonary hypertension. The prevalence of these cardiac complications in children with SCD living in the Netherlands is unknown. The role of hemolysis in this process is still unclear. Therefore, the objectives of this study are: 1) to evaluate the prevalence of cardiac abnormalities in children with SCD living in the Netherlands, 2) to analyse the association between cardiac abnormalities and the severity of anemia and hemolysis. Methods: Cross-sectional study, including 92 children with SCD (genotype HBSS, HBSC or HBS-beta 0) treated at the Emma Children's Hospital AMC. None of the children had cardiac abnormalities unrelated to SCD. Echocardiograms and electrocardiograms were performed in a stable state. All cardiac values were corrected for BSA. Echocardiographic values 20% above or under the average of an age matched control group were considered abnormal. Laboratory hematological parameters were obtained within one year of the cardiac imaging. All statistical analyses were performed with SPSS 18 software, using Pearson correlations and T-tests. Forced-entry multivariate regression analysis was conducted with hematological parameters, age and SCD genotype as independent variables and cardiologic parameters as dependent variables. Results: The study group had a mean age of 13 years (SD 5,5) and contained 49 boys (53,3%). All children had a normal shortening fraction. Almost half of the children (39%) had a dilated left ventricular internal diameter in diastole and systole. Dilatation was inversely correlated with the Hb level. When analysed with multivariate analysis, both Hb and bilirubin were independently associated with left ventricular dilatation, suggesting that hemolysis deteriorates cardiac structure by a mechanism separate from the effect of anemia. There was no association between the left ventricular dilatation and age. Conclusion: Pediatric sickle cell patients have significant dilatation of the left ventricle, an abnormality that is significantly and independently associated with the severity of anemia and bilirubin levels, but in spite retain a normal shortening fraction. Disclosures: No relevant conflicts of interest to declare.
27

Sorensen, K., G. Levitt, D. Sebag-Montefiore, C. Bull, and I. Sullivan. "Cardiac function in Wilms' tumor survivors." Journal of Clinical Oncology 13, no. 7 (July 1995): 1546–56. http://dx.doi.org/10.1200/jco.1995.13.7.1546.

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PURPOSE To study late cardiac function in a single diagnostic group (children with Wilms' tumor) with good long-term survival; to compare patients treated with anthracyclines (doxorubicin) with patients treated without anthracyclines and with a normal child/adolescent group; and to examine the risk factors involved in late cardiac dysfunction. PATIENTS AND METHODS Echocardiographic studies were performed on 97 Wilms' tumor patients treated with anthracyclines (mean cumulative dose, 303 mg/m2) with a mean follow-up time of 7.1 years, on 39 Wilms' tumor patients treated without anthracyclines with a mean follow-up time of 8.9 years, and on 50 normal subjects. Left ventricular (LV) dimensions, end systolic wall stress (a measure of afterload), and load-dependent and -independent measures of contractility were compared between groups. Potential risk factors, including age at diagnosis, follow-up duration, sex, pubertal status, cardiac irradiation, dose-intensity, and cumulative dose of anthracyclines, were studied by multivariate analysis. RESULTS Twenty-five percent of the anthracycline-treated group showed cardiac abnormalities. All but one of these patients had increased LV afterload. Risk factors for increased afterload were anthracycline cumulative dose (P < .05) and anthracycline dose-intensity (P < .02). Wilms' tumor patients treated without anthracyclines had thickened LV walls compared with normal subjects (P < .05). CONCLUSION Total dose and dose-intensity of anthracycline were risk factors for increased LV afterload in long-term Wilms' tumor survivors treated on standard protocols. The increase in afterload accounted for reduced LV shortening, whereas contractility was rarely abnormal. The new finding that Wilms' tumor survivors who do not receive anthracyclines have mild LV hypertrophy may provide some protection against anthracycline-induced cardiotoxic effects.
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Cantinotti, Massimiliano, Pietro Marchese, Marco Scalese, Eliana Franchi, Nadia Assanta, Martin Koestenberger, Alessandra Pizzuto, et al. "Atrial Function Impairments after Pediatric Cardiac Surgery Evaluated by STE Analysis." Journal of Clinical Medicine 11, no. 9 (April 29, 2022): 2497. http://dx.doi.org/10.3390/jcm11092497.

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Background: Applications of atrial speckle tracking echocardiography (STE) strain (ε) analysis in pediatric cardiac surgery have been limited. This study aims to evaluate the feasibility of atrial STE ε analysis and the progression of atrial ε values as a function of post-operative time in children after pediatric cardiac surgery. Methods: 131 children (mean 1.69 ± 2.98; range 0.01–15.16 years) undergoing cardiac surgery were prospectively enrolled. Echocardiographic examinations were performed pre-operatively and at 3 different post-operative intervals: Time 1 (24–36 h), Time 2 (3–5 days), Time 3 (>5 days, before discharging). The right and left atrium longitudinal systolic contractile (Ct), Conduit (Cd), and Reservoir (R) ε were evaluated with a novel atrial specific software with both P- and R-Gating methods. One hundred and thirty-one age-matched normal subjects (mean 1.7 ± 3.2 years) were included as controls. Results: In all, 309 examinations were performed over the post-operative times. For each post-operative interval, all STE atrial ε parameters assessed were significantly lower compared to controls (all p < 0.0001). The lowest atrial ε values were found at Time 1, with only partial recovery thereafter (p from 0.02 to 0.04). All atrial ε values at discharge were decreased compared to the controls (all p < 0.0001). Significant correlations of the atrial ε values with cardio-pulmonary-bypass time, left and right ventricular ε values (p < 0.05), and ejection fraction (p < 0.05) were demonstrated. Conclusions: Atrial ε is highly reduced after surgery with only partial post-operative recovery in the near term. Our study additionally demonstrates that post-surgical atrial and ventricular ε responses correlated with each other.
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Kumar, Sanjay, Amit Nautiyal, Saurabh Kaushik, Jason M. Lazar, and Richard A. Grimm. "IMPACT OF CARDIAC RESYNCHRONIZATION THERAPY ON DIASTOLIC FUNCTION: A META-ANALYSIS." Journal of the American College of Cardiology 55, no. 10 (March 2010): A23.E221. http://dx.doi.org/10.1016/s0735-1097(10)60222-7.

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30

Dickstein, Marc L., Henry M. Spotnitz, Eric A. Rose, and Daniel Burkhoff. "Heart reduction surgery: An analysis of the impact on cardiac function." Journal of Thoracic and Cardiovascular Surgery 113, no. 6 (June 1997): 1032–40. http://dx.doi.org/10.1016/s0022-5223(97)70288-5.

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31

Cho, Peter W., Howard R. Levin, William E. Curtis, Joshua E. Tsitlik, Joseph M. DiNatale, David A. Kass, Timothy J. Gardner, Ralph W. Kunel, and Michael A. Acker. "Pressure-volume analysis of changes in cardiac function in chronic cardiomyoplasty." Annals of Thoracic Surgery 56, no. 1 (July 1993): 38–45. http://dx.doi.org/10.1016/0003-4975(93)90400-c.

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32

Tokodi, Marton, Sirish Shrestha, Muhammad Ashraf, Grace Casaclang-Verzosa, and Partho Sengupta. "TOPOLOGICAL DATA ANALYSIS FOR QUANTIFYING INTER-PATIENT SIMILARITIES IN CARDIAC FUNCTION." Journal of the American College of Cardiology 73, no. 9 (March 2019): 751. http://dx.doi.org/10.1016/s0735-1097(19)31359-2.

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33

Cala, Steven E., Nicholas Carruthers, Joseph Caruso, Paul Stemmer, and Xuequn Chen. "Function Based Analysis of the Cardiac Endoplasmic and Sarcoplasmic Reticulum Proteome." Biophysical Journal 112, no. 3 (February 2017): 160a—161a. http://dx.doi.org/10.1016/j.bpj.2016.11.883.

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34

Sanapo, L., O. M. Turan, S. Turan, J. Ton, M. Atlas, and A. A. Baschat. "Correlation analysis of ductus venosus velocity indices and fetal cardiac function." Ultrasound in Obstetrics & Gynecology 43, no. 5 (April 3, 2014): 515–19. http://dx.doi.org/10.1002/uog.13242.

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35

Herling, L., J. Johnson, K. Ferm-Widlund, F. Bergholm, P. Lindgren, S. E. Sonesson, G. Acharya, and M. Westgren. "Automated analysis of fetal cardiac function using color tissue Doppler imaging." Ultrasound in Obstetrics & Gynecology 52, no. 5 (October 1, 2018): 599–608. http://dx.doi.org/10.1002/uog.18812.

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36

Badilini, Fabio, Martino Vaglio, Rémi Dubois, Pierre Roussel, Nenad Sarapa, Isabelle Denjoy, Fabrice Extramiana, and Pierre Maison-Blanche. "Automatic analysis of cardiac repolarization morphology using Gaussian mesa function modeling." Journal of Electrocardiology 41, no. 6 (November 2008): 588–94. http://dx.doi.org/10.1016/j.jelectrocard.2008.07.020.

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37

Michaely, Henrik J., Kambiz Nael, Stefan O. Schoenberg, Gerhard Laub, Maximilian F. Reiser, J. Paul Finn, and Stefan G. Ruehm. "Analysis of Cardiac Function???Comparison Between 1.5 Tesla and 3.0 Tesla Cardiac Cine Magnetic Resonance Imaging." Investigative Radiology 41, no. 2 (February 2006): 133–40. http://dx.doi.org/10.1097/01.rli.0000192023.96494.af.

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38

Goel, Shom, R. John Simes, and Jane M. Beith. "Exploratory analysis of cardiac biomarkers in women with normal cardiac function receiving trastuzumab for breast cancer." Asia-Pacific Journal of Clinical Oncology 7, no. 3 (August 28, 2011): 276–80. http://dx.doi.org/10.1111/j.1743-7563.2011.01422.x.

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39

Tanaka, Yuji, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, and Takashi Inuzuka. "Cardiac sympathetic function in the patients with amyotrophic lateral sclerosis: analysis using cardiac [123I] MIBG scintigraphy." Journal of Neurology 260, no. 9 (June 20, 2013): 2380–86. http://dx.doi.org/10.1007/s00415-013-7005-0.

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40

Claros-Guzmán, Alfonso, Martín G. Rodríguez, Birmania Heredia-Rivera, and Rodolfo González-Segovia. "Three-dimensional analysis of the heart function and effect cholinergic agonists in the cockroach Gromphadorhina portentosa." Journal of Comparative Physiology A 206, no. 6 (September 21, 2020): 857–70. http://dx.doi.org/10.1007/s00359-020-01443-5.

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Abstract Many relevant aspects of mammal’s cardiac physiology have been mainly investigated in insect models such as Drosophila melanogaster and Periplaneta americana. Cardiac function has been poorly studied in the cockroach Gromphadorhina portentosa, which has some advantages for experimental purposes such as an easier culture, bigger organs and a robust physiology. On the other hand, the study of cardiac physiology in insects has been largely improved since the arrival of digital imaging technologies for recording purposes. In the present work, we introduce a methodology of video recording coupled to an isotonic transducer for a three-dimensional analysis of the heart and intracardiac valves of G. portentosa. We used this methodology for assessing the physiological responses of the cockroach heart upon the application of different cholinergic neurotransmitters (acetylcholine, nicotine and muscarine). We recorded in detail the relationship between intracardiac valves movement, hemolymph flow, diastole and systole. Acetylcholine and nicotine induced a biphasic effect on the cardiac frequency. Acetylcholine increased the diastolic opening. Nicotine at high concentration caused paralysis. Muscarine induced no major effects. These findings suggest a combined action of cholinergic agonists for a finely tuned the cardiac frequency, intracardiac valves function and cardiac cycle.
41

Lupenko, Serhii, Nadiia Lutsyk, Oleh Yasniy, and Łukasz Sobaszek. "Statistical Analysis of Human Heart Rhythm with Increased Informativeness." Acta Mechanica et Automatica 12, no. 4 (December 1, 2018): 311–15. http://dx.doi.org/10.2478/ama-2018-0047.

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Abstract The new methods of statistical analysis of heart rhythm were developed based on its generalized mathematical model in a form of random rhythm function, that allows to increase the informativeness and detailed analysis of heart rhythm in cardiovascular information systems. Three information criteria (BIC, AIC and AICc) were used to determine the cumulative distribution functions that best describe the sample and to assess the unknown parameters of distributions. The usage of the rhythm function to analyse heart rhythm allows to consider much better its time structure that is the basis to improve the accuracy of diagnosis of cardiac rhythm.
42

Atifa Rahmi, Koyuki, Husnul Khotimah, and Mohammad Saifur. "A Simple Analysis and Scoring of Zebrafish Larvae Cardiac Performance in Teratogenicity Study using Light Microscopy and ImageJ Software." International Journal of Pharmaceutical and Bio-Medical Science 04, no. 01 (January 31, 2024): 44–51. http://dx.doi.org/10.47191/ijpbms/v4-i1-07.

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Background: Zebrafish is one of the suitable model organisms for teratogenicity study. One of the organs assessed during the study is the heart. There has been an established scoring system for the cardiac morphology, but not cardiac performance. Furthermore, the assessment of cardiac function in zebrafish often use expensive instruments and complicated methods. Materials and Methods: Cardiac performance scoring method and system was proposed for zebrafish larvae aged 5 dpf. Observation was done using light microscope and the video of the observation was taken using smartphone or camera. The videos were then converted and rendered to be compatible with the ImageJ program using the measure function and time series analyzer plugin. The assessed parameters were the heart rate and rhythm, strength of heart contraction, and synchronicity between atrium and ventricle. Results: The scoring system was formulated based on the assessments towards healthy control 5 dpf zebrafish larvae and references. The score for cardiac performance ranged from 3 – 6, with score 3 representing arrhythmic, weak, and asynchronous contractions, while score 6 representing rhythmic, strong, and synchronous contraction. The scoring system was also valid to point out the difference in cardiac performance between healthy control zebrafish larvae and larvae that previously exposed to lithium as teratogenic agent (p = 0.000). Conclusions: The scoring methods and system developed in this study allowed for a non – expensive and simple assessment of cardiac performance in zebrafish larvae aged 5 dpf, especially for a teratogenicity study.
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Prieto-Carrasco, Rodrigo, Alejandro Silva-Palacios, Pedro Rojas-Morales, Omar Emiliano Aparicio-Trejo, Estefany Ingrid Medina-Reyes, Estefani Yaquelin Hernández-Cruz, Carlos Sánchez-Garibay, et al. "Unilateral Ureteral Obstruction for 28 Days in Rats Is Not Associated with Changes in Cardiac Function or Alterations in Mitochondrial Function." Biology 10, no. 7 (July 16, 2021): 671. http://dx.doi.org/10.3390/biology10070671.

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Our work evaluated cardiac function and mitochondrial bioenergetics parameters in hearts from male Wistar rats subjected to the UUO model during 28 days of progression. We measured markers of kidney damage and inflammation in plasma and renal fibrosis by histological analysis and Western blot. Cardiac function was evaluated by echocardiography and proteins involved in cardiac damage by Western blot. Oxygen consumption and transmembrane potential were monitored in cardiac mitochondria using high-resolution respirometry. We also determined the activity of ATP synthase and antioxidant enzymes such as glutathione peroxidase, glutathione reductase, and catalase. Our results show that, although renal dysfunction is established in animals subjected to ureteral obstruction, cardiac function is maintained along with mitochondrial function and antioxidant enzymes activity after 28 days of injury evolution. Our results suggest that renocardiac syndrome might develop but belatedly in obstruction-induced renal damage, opening the opportunity for treatment to prevent this condition.
44

Zhou, Ying, and Xiwei Zhang. "Analysis of Cardiac Functional Status and Factors Influencing Adverse Pregnancy Outcomes in Pregnant Women with Combined Heart Disease." Journal of Clinical and Nursing Research 8, no. 5 (June 20, 2024): 1–6. http://dx.doi.org/10.26689/jcnr.v8i5.7283.

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Objective: To investigate the cardiac function of pregnant women with complicated heart disease during pregnancy and the factors influencing the adverse pregnancy outcome. Methods: A total of 162 cases of pregnant women with complicated heart disease admitted to the Beijing Anzhen Hospital from October 2021 to December 2023 were selected to compare the occurrence of adverse pregnancy outcomes in pregnant women with complicated heart disease at different levels of cardiac function and to analyze the single and multi factors leading to adverse pregnancy outcomes in pregnant women with complicated heart disease. Results: Among 162 pregnant women with combined heart disease in pregnancy, the highest percentage of heart disease type was congenital heart disease (80/49.38%), and the lowest percentage was other (9/5.56%); the overall incidence of adverse pregnancy outcomes in pregnant women with combined heart disease in pregnancy with cardiac function grades of 3–4 cardiac function (30/68.18%) was higher than that in pregnant women with combined heart disease in cardiac function grades of 1–2 (40 /33.90%) (P = 0.000); age, marital status, hypertension, and past history of all pregnant women were not statistically significant (P > 0.05); gestational age, type of heart disease, and cardiac function grading were statistically significant (P < 0.05), and these factors were all independent risk factors for adverse pregnancy resolution in pregnant women with combined heart disease (P < 0.05). Conclusion: The overall incidence of adverse pregnancy outcomes was higher in pregnant women with heart disease than in those with heart disease grades 1–2, and the number of pregnancies, the type of heart disease, and heart function grades were all independent risk factors for adverse pregnancy outcomes in pregnant women with heart disease.
45

Lou, Bowen, Yongbai Luo, Haoxuan Zhang, Haoyu Wu, Gulinigaer Tuerhong Jiang, Hui Liu, Kejia Kan, et al. "Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis." Disease Markers 2022 (April 23, 2022): 1–12. http://dx.doi.org/10.1155/2022/7267937.

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Background. Acute myocardial infarction (AMI), as well as its long-term and short-term complications, is known to present with high morbidity and mortality. Cardiac function deterioration and ventricular remodelling after AMI are known to be correlated to worse long-term outcomes. However, the underlying mechanism remains elusive and there is a shortage of serum prediction markers. This study investigates the relationship between in-hospital Cystatin C (CysC) and cardiac function and subsequent prognosis among AMI patients. Research Design and Methods. We measured admission CysC and cardiac function parameters, including ejection fraction (EF) and pro-BNP value in 5956 patients diagnosed with AMI. Simple and multiregression analyses were performed to investigate the correlation between CysC and cardiac function in AMI patients. Major adverse cardiovascular events (MACE), cardiovascular, and all-cause mortality were documented, and 351 participants with high cystatin (≥1.09 mg/L) and 714 low cystatin (<1.09 mg/L) were investigated for survival analysis during a 48-month follow-up. Results. 5956 patients with AMI were enrolled in the initial observational analysis, and 1065 patients of the whole cohort were included in the follow-up survival analysis. The admission CysC level was found to be significantly positively correlated to the pro-BNP level ( R square = 0.2142 , 95% CI 4758 to 5265, p < 0.0001 ) and negatively correlated to the EF value ( R square = 0.0095 , 95% CI -3.503 to -1.605, p < 0.0001 ). Kaplan-Meier survival analysis revealed significantly increased MACE incidence ( HR = 2.293 , 95% CI 1.400 to 3.755, p < 0.0001 ), cardiovascular mortality ( HR = 3.016 , 95% CI 1.694 to 5.371, p = 0.0002 ), and all-cause mortality ( HR = 3.424 , 95% CI 2.010 to 5.835, p < 0.0001 ) in high-admission CysC cohort with AMI at the end of 4-year follow-up. Conclusions. Admission CysC is negatively correlated with cardiac function in AMI patients and acts as a novel predictor for MACE incidence in the whole population. Further studies are needed to investigate the specific mechanism of CysC in the cardiac function deterioration among AMI patients.
46

Io, Hiroaki, Yuuki Ro, Yoshimi Sekiguchi, Tetsutaro Shimaoka, Jiro Inuma, Yoko Hotta, Seiki Aruga, et al. "Cardiac Function and Structure in Longitudinal Analysis of Echocardiography in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 30, no. 3 (May 2010): 353–61. http://dx.doi.org/10.3747/pdi.2009.00007.

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♦ BackgroundEchocardiography is widely used for the evaluation of cardiac structures and function. The prognostic value of assessment of left cardiac atrium (LA) size in peritoneal dialysis (PD) patients is still unclear. The objective of the present study is to investigate prospectively a longitudinal monitoring of echocardiography parameters after start of PD. We also investigated a correlation study among plasma atrial natriuretic peptide (ANP) level, LA size, and cardiac function undergoing aggressive treatment.♦ MethodsCorrelation among plasma ANP, LA size, and cardiac function was prospectively analyzed by Doppler echocardiography in 32 PD patients in Juntendo University Hospital, Tokyo. Measurement of these parameters was performed at 0, 6, 12, 18, and 24 months after start of PD. All patients were treated with an angiotensin type 1 receptor blocker to control blood pressure to less than 140/90 mmHg. Other antihypertensive drugs such as diuretics and/or calcium channel blockers were added if blood pressure rose to over 140/90 mmHg. Hemoglobin and hematocrit levels were targeted at 10.0 g/dL and 30.0% respectively with recombinant human erythropoietin treatment. A diuretic was added or patients decreased their water intake if ANP was more than 43.0 pg/mL or LA diameter (LAD) more than 39 mm, and for other basic markers of volume status. Cardiac function was measured before and after drainage of PD fluid to evaluate the influence of cardiac function.♦ ResultsLAD at start of dialysis (36 ± 4.6 mm) decreased significantly to 33 ± 3.3 mm ( p < 0.05), 33 ± 3.2 mm ( p < 0.05), and 33 ± 3.6 mm ( p < 0.05) after 6, 12, and 24 months, respectively. Ejection fraction after 6 months was significantly increased compared with that at start of dialysis ( p < 0.05). Left ventricular mass index (LVMI) after 6, 12, and 24 months was significantly decreased compared with that at start of dialysis ( p < 0.05). ANP was 56 ± 39 pg/mL at start of dialysis and decreased significantly to 33 ± 19 pg/mL after 24 months ( p < 0.05). ANP was significantly correlated with LAD ( r = 0.412, p < 0.01), transmitral A wave flow velocity ( r = 0.429, p < 0.01), and LVMI ( r = 0.426, p < 0.01). Instillation of the dialysis fluid did not affect any parameters except inferior vena cava dimension.♦ ConclusionsThis study demonstrates a reduction in LA size and LVMI in PD patients followed over 24 months. Left ventricular structure, contraction, and compliance were well preserved in PD patients undergoing aggressive treatment based on measurements of plasma ANP and LAD.
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Cai, Wanwan, Yuequn Wang, Ying Luo, Luoqing Gao, Jian Zhang, Zhigang Jiang, Xiongwei Fan, et al. "asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function." International Journal of Molecular Sciences 24, no. 22 (November 15, 2023): 16364. http://dx.doi.org/10.3390/ijms242216364.

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Ankyrin repeat and suppression-of-cytokine-signaling box (Asb) proteins, a subset of ubiquitin ligase E3, include Asb5 with six ankyrin-repeat domains. Zebrafish harbor two asb5 gene isoforms, asb5a and asb5b. Currently, the effects of asb5 gene inactivation on zebrafish embryonic development and heart function are unknown. Using CRISPR/Cas9, we generated asb5a-knockout zebrafish, revealing no abnormal phenotypes at 48 h post-fertilization (hpf). In situ hybridization showed similar asb5a and asb5b expression patterns, indicating the functional redundancy of these isoforms. Morpholino interference was used to target asb5b in wild-type and asb5a-knockout zebrafish. Knocking down asb5b in the wild-type had no phenotypic impact, but simultaneous asb5b knockdown in asb5a-knockout homozygotes led to severe pericardial cavity enlargement and atrial dilation. RNA-seq and cluster analyses identified significantly enriched cardiac muscle contraction genes in the double-knockout at 48 hpf. Moreover, semi-automatic heartbeat analysis demonstrated significant changes in various heart function indicators. STRING database/Cytoscape analyses confirmed that 11 cardiac-contraction-related hub genes exhibited disrupted expression, with three modules containing these genes potentially regulating cardiac contractile function through calcium ion channels. This study reveals functional redundancy in asb5a and asb5b, with simultaneous knockout significantly impacting zebrafish early heart development and contraction, providing key insights into asb5’s mechanism.
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Hoelscher, Sarah C., Theresia Stich, Anne Diehm, Harald Lahm, Martina Dreßen, Zhong Zhang, Irina Neb, et al. "miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations." International Journal of Molecular Sciences 21, no. 3 (February 10, 2020): 1158. http://dx.doi.org/10.3390/ijms21031158.

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MicroRNAs (miRs) appear to be major, yet poorly understood players in regulatory networks guiding cardiogenesis. We sought to identify miRs with unknown functions during cardiogenesis analyzing the miR-profile of multipotent Nkx2.5 enhancer cardiac progenitor cells (NkxCE-CPCs). Besides well-known candidates such as miR-1, we found about 40 miRs that were highly enriched in NkxCE-CPCs, four of which were chosen for further analysis. Knockdown in zebrafish revealed that only miR-128a affected cardiac development and function robustly. For a detailed analysis, loss-of-function and gain-of-function experiments were performed during in vitro differentiations of transgenic murine pluripotent stem cells. MiR-128a knockdown (1) increased Isl1, Sfrp5, and Hcn4 (cardiac transcription factors) but reduced Irx4 at the onset of cardiogenesis, (2) upregulated Isl1-positive CPCs, whereas NkxCE-positive CPCs were downregulated, and (3) increased the expression of the ventricular cardiomyocyte marker Myl2 accompanied by a reduced beating frequency of early cardiomyocytes. Overexpression of miR-128a (4) diminished the expression of Isl1, Sfrp5, Nkx2.5, and Mef2c, but increased Irx4, (5) enhanced NkxCE-positive CPCs, and (6) favored nodal-like cardiomyocytes (Tnnt2+, Myh6+, Shox2+) accompanied by increased beating frequencies. In summary, we demonstrated that miR-128a plays a so-far unknown role in early heart development by affecting the timing of CPC differentiation into various cardiomyocyte subtypes.
49

Campos, J. O., J. Sundnes, R. W. dos Santos, and B. M. Rocha. "Uncertainty quantification and sensitivity analysis of left ventricular function during the full cardiac cycle." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 378, no. 2173 (May 25, 2020): 20190381. http://dx.doi.org/10.1098/rsta.2019.0381.

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Patient-specific computer simulations can be a powerful tool in clinical applications, helping in diagnostics and the development of new treatments. However, its practical use depends on the reliability of the models. The construction of cardiac simulations involves several steps with inherent uncertainties, including model parameters, the generation of personalized geometry and fibre orientation assignment, which are semi-manual processes subject to errors. Thus, it is important to quantify how these uncertainties impact model predictions. The present work performs uncertainty quantification and sensitivity analyses to assess the variability in important quantities of interest (QoI). Clinical quantities are analysed in terms of overall variability and to identify which parameters are the major contributors. The analyses are performed for simulations of the left ventricle function during the entire cardiac cycle. Uncertainties are incorporated in several model parameters, including regional wall thickness, fibre orientation, passive material parameters, active stress and the circulatory model. The results show that the QoI are very sensitive to active stress, wall thickness and fibre direction, where ejection fraction and ventricular torsion are the most impacted outputs. Thus, to improve the precision of models of cardiac mechanics, new methods should be considered to decrease uncertainties associated with geometrical reconstruction, estimation of active stress and of fibre orientation. This article is part of the theme issue ‘Uncertainty quantification in cardiac and cardiovascular modelling and simulation’.
50

Kumar, Sanjay, Saurabh Kaushik, and Richard A. Grimm. "Impact of Diastolic Function on Systolic Function in Patients Undergoing Cardiac Resynchronization Therapy: A Meta-Analysis." Journal of Cardiac Failure 14, no. 6 (August 2008): S88. http://dx.doi.org/10.1016/j.cardfail.2008.06.239.

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