Дисертації з теми "Cardiac function analysis"
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Wang, Haiyan. "Cardiac motion and function analysis using MR imaging." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/30717.
Piva, Rosa Maria Volpi. "Analysis and visualization of cardiac wall motion from magnetic resonance images." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246777.
Prakosa, Adityo. "Analysis and simulation of multimodal cardiac images to study the heart function." Phd thesis, Université Nice Sophia Antipolis, 2013. http://tel.archives-ouvertes.fr/tel-00837857.
Shi, Wenzhe. "An image segmentation and registration approach to cardiac function analysis using MRI." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10548.
Rehmani, Taha. "An In-vivo Analysis of SLMAP Function in the Postnatal Mouse Myocardium." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36666.
Vigneault, Davis Marc. "Quantification of regional cardiac function : clinically-motivated algorithm development and application to cardiac magnetic resonance and computed tomography." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:b158793e-5f68-4aad-9335-f143e5864886.
Grunert, Marcel [Verfasser]. "Computational analysis of next-generation sequencing data in cardiac function and disease / Marcel Grunert." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1029963150/34.
Ahlsson, Anders. "Atrial fibrillation in cardiac surgery." Doctoral thesis, Örebro universitet, Hälsoakademin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2442.
Cloud, Jennifer Ellen 1976. "Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29593.
Includes bibliographical references.
The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of the "activating E2F" subfamily that is important for the transcriptional activation of target genes involved in DNA replication and cell cycle control. These E2F family members are essential for cellular proliferation in vitro. This study analyzes the role of the activating E2Fs in vivo using mutant mouse models. It demonstrates that E2F3 is essential for viability in a strain dependent manner. E2f3 animals die at three distinct time points from cardiac etiologies. The embryonic and neonatal lethality of these animals is consistent with proliferation defects in the myocardium that result in hypoplastic heart walls and septa. E2f animals that survive the perinatal period eventually die from highly penetrant, late-onset congestive heart failure. This is the first evidence that proliferation regulators have an important role in adult heart failure. In addition, this study examines the relative roles of E2F1 and E2F3 in vivo. It shows that E2F1 and E2F3 have functional overlap during mouse development as well as in the maintenance of a number of adult tissues. However, E2F1 appears to have a distinct function as a tumor suppressor gene. Importantly, E2F1 and E2F3 both contribute to normal cardiac function. Furthermore, mutation of the gene for the pRB protein that negatively regulates the activating E2Fs can rescue the heart failure in the E2f3 animals. These data argue strongly that proper regulation of proliferation is critical for adult cardiac function.
by Jennifer Ellen Cloud.
Ph.D.
Kaniewska, Malwina [Verfasser]. "Noninvasive evaluation of cardiac function using Computed Tomography and Magnetic Resonance Imaging : a meta-analysis / Malwina Kaniewska." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140486861/34.
MOHAMMED, Nadiya Younis. "Study of internal jugular vein valve mechanism function: post analysis of M- mode imaging and an experimental model under cardiac monitoring." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2488097.
Introduzione: Lo studio emodinamico della vena giugulare interna (IJV) fornisce indicazioni sulla funzionalità cardiaca. La vena giugulare interna è dotata di una valvola che ha una funzione protettiva, studi recenti si sono concentrati sul comportamento dinamico della valvola e sulla sua importanza nella regolazione del flusso ematico cerebrale. Questi studi hanno mostrato che questa valvola ha la funzione di regolare il gradiente della pressione nell’asse cervello – cuore. L’assenza o l'incompetenza funzionale della valvola può anche portare al fenomeno del reflusso venoso attraverso la IJV. Tuttavia, il meccanismo dell'apertura e della chiusura della valvola non è stato ancora studiato a fondo, in particolare non sono si hanno informazioni sul suo ritmo di apertura e chiusura. Inoltre, non vi sono conoscenze sufficienti per capire se il fenomeno del reflusso venoso sia normale o possa essere associato a incompetenza della valvola e quindi indicatore di possibili stati patologici. Obiettivo dello studio: Il progetto mira ad individuare nuovi indicatori della funzione della valvola giugulare interna attraverso: 1) Studio delle immagini ecografiche della valvola acquisite in M mode; 2) Utilizzo di circuito fluidodinamico sperimentale per lo studio della relazione tra impulso pressorio a monte e a valle della vena giugulare ed il suo flusso in presenza ed assenza della valvola interna. Metodi: Un gruppo soggetti normali sono stati sottoposti ad ecografia del collo in posizione supina. La valvola vena giugulare interna è stata studiata usando le immagini acquisite sia B-mode che M-mode. Sono stati utilizzati due metodi per ricavare informazioni sui tempi di apertura e di chiusura della valvola. Il primo metodo è basato sul calcolo dell'area sottesa dalla curva che rappresenta la distanza di separazione del lembo della valvola per un intero ciclo cardiaco. Il secondo metodo vuole introdurre test logici utilizzando tre soglie di riferimento per studiare la distanza di separazione delle alette della valvola. E’ stato realizzato un circuito idraulico che imita la fluidodinamica del tratto Ventricolo – Cervello – Atrio utilizzando una pompa programmabile (Compu Flow 1000, Shelley Medical Imaging / London / Canada) che immette un fluido in un circuito ad anello avente segmenti che possono simulare la vena Giugulare con e senza valvola Risultati: Il primo metodo di studio del tempo apertura ha una buona correlazione positiva con metodo logico quando si utilizza il parametro di soglia soglia 0,5. Il tempo di apertura della valvola IJV è circa il 70% della durata di ogni ciclo cardiaco. Il modello sperimentale fornisce risultati specifici per le due diverse misure di flusso e pressione (a monte e a valle) dei fantocci. Il fenomeno del reflusso si verifica all'inizio dell'onda di flusso pulsatile in una posizione a valle per il flussi più alti. La differenza di pressione tra le due posizioni aumenta con la portata media e diminuisce crescere della portata nel fantoccio senza valvola mentre nell’altro (con valvola), la differenza di pressione ha un andamento lineare con la portata. Conclusioni: Il tempo di apertura della valvola vena giugulare interna rappresenta una nuova metrica fisiologica che può essere utilizzata per ulteriori studi più approfonditi nel campo della insufficienze del ritorno venoso cerebrale. Il modello sperimentale ha aggiunto di un nuove informazioni sulla comparsa del al reflusso venoso nei simulatori della vena giugulare interna e sulla funzione della della valvola nel mantenere un'adeguata gradiente pressorio nella IJV.
Bowers, Mark Charles 1963. "Sequential analysis of multidrug resistance protein-1 expression and function in cardiac transplant patients: A possible mechanism of therapy-resistant acute rejection." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282822.
Huang, Xueying. "Segmentation of patient-specific 3D cardiac magnetic resonance images of human right ventricle." Worcester, Mass. : Worcester Polytechnic Institute, 2008. http://www.wpi.edu/Pubs/ETD/Available/etd-030408-151600/.
Keywords: CMRI; segmentation; digital contour; right ventricle; ventricle function analysis. Includes bibliographical references (leaves 49-53 ).
Tee, Michael Weiseng. "Image analysis of cardiac computed tomography towards regional functional analysis." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:14f50b88-1af6-40b6-91b3-9e39d77fe83a.
Darwich, Rami. "Functional Analysis of KLF13 in the Heart." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34317.
Wu, Ling. "Functional Characterization of SCN5A, The Cardiac Sodium Channel Gene Associated With Cardiac Arrhythmias and Sudden Death." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1206732295.
Bernardino, Gabriel. "Computational anatomy as a driver of understanding structural and functional cardiac remodeling." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668213.
Presentamos un framework de análisis estadístico de forma para identificar remodelado cardiaco teniendo en cuenta la variabilidad natural de cada individuo. Utilizamos este framework en dos aplicaciones clínicas: triatletas e individuos nacidos pequeños-para-su-edad-gestacional (SGA). Identificamos el remodelado cardiaco en el caso de los triatletas: consistente en una dilatación del ventrículo izquierdo y un aumento de la masa miocárdica. En el ventrículo derecho (RV) la dilatación estaba concentrada en el tracto de salida. Este remodelado correlaciona con una mejor respuesta al ejercicio. En el análisis de SGA, encontramos sutiles cambios en el RV que correlacionaban con una peor respuesta al ejercicio. Estos cambios de forma fueron mayores si SGA se encontraba combinada con otros factores de riesgo cardiaco: tabaco y sobrepeso. Finalmente, presentamos una parcelación de la cavidad del RV en 3 subvolumenes para el análisis regional del RV cuando no es posible la correspondencia punto-a-punto.
Siriwittayawan, Duangduan. "Functional analysis of regulatory phosphorylation events in cardiac KATP channel subunits in ischaemia." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/10384.
Casero, Cañas Ramón. "Left ventricle functional analysis in 2D+t contrast echocardiography within an atlas-based deformable template model framework." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:b17b3670-551d-4549-8f10-d977295c1857.
Petitjean, Caroline. "Recalage non rigide d'images par approches variationnelles statistiques - Application à l'analyse et à la modélisation de la fonction myocardique en IRM." Phd thesis, Université René Descartes - Paris V, 2003. http://tel.archives-ouvertes.fr/tel-00273241.
Cette thèse se propose de démontrer que les techniques de recalage non rigide statistique constituent un cadre approprié pour l'estimation des déformations myocardiques en IRM, leur quantification à des fins diagnostiques, et leur modélisation en vue d'établir une référence numérique de normalité. Ses contributions concernent :
1. l'élaboration d'une méthode robuste non supervisée d'estimation des déplacements myocardiques à partir de séquences d'IRM de marquage. Elle permet l'obtention de mesures de mouvement fiables en tout point du myocarde, à tout instant du cycle cardiaque et sous incidence de coupe arbitraire.
2. le développement d'un outil de quantification dynamique des déformations à l'échelle du pixel et du segment myocardique, intégrant un étape de segmentation automatique du coeur par recalage d'images ciné IRM acquises conjointement aux données de marquage. Pour le coeur sain, la comparaison des mesures obtenues à des valeurs de référence issues d'une synthèse approfondie de la littérature médicale démontre une excellente corrélation. Pour des coeurs pathologiques, les expériences menées ont montré la pertinence d'une analyse quantitative multiparamétrique pour localiser et caractériser les zones atteintes.
3. la construction d'un modèle statistique (atlas) de contraction d'un coeur sain. Cet atlas fournit des modèles quantitatifs de référence locaux et segmentaires pour les paramètres de déformation. Son intégration, en tant que modèle de mouvement, au processus de recalage des données d'IRM de marquage conduit en outre à une description très compacte des déplacements myocardiques sans perte de précision notable.
Dondi, Cristiana. "Molecular and functional analysis of cardiac diversification by cell specific translatomic approaches in Drosophila Melanogaster." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAS003/document.
Cardiac cells diversification is required for the formation of a functional heart. Human heart is a multi-lineage organ that develops through progressive diversification of progenitors derived from different heart fields. This process is underlined by numerous changes in the expression of a repertory of genes that allow cells to acquire their own identity and functions. The Drosophila embryo is a relatively simple model to study the diversification of cardiac cells and their properties. The goal of this project is to identify the repertories of genes that control the formation of different types of cardiac cells. To reach this objective we applied Translation Ribosome Affinity Purification (TRAP) method followed by RNA sequencing in order to identify mRNA engaged in translation specific to two cardiac cell types (Tinman (Tin) and Labybird (Lb) expressing cells), at two different time windows. We obtained a list of enriched genes for the different types of cardiac cells and time points. In a first part, we focused our attention on the Tindatasets and found that two genes, CAP and Msp300, are involved in cardioblasts migration during the heart closure. Then we identified two other candidate genes kontiki and dGrip that seem to contribute to maintain cohesion between CBs during heartmorphogenesis. Moreover by comparing our spatial datasets, we found that for the same time point, around 60% of Tin CBs enriched genes are common with Lb CBs enriched population and within this group we identified evolutionary conserved genes such as Src42, flr and sqa known to be involved in the cytoskeleton organization and in the actinpolymerization and depolymerisation. Our premiminary analyses show that they seem to be required for correct cardiac morphogenesis. We also identified sets of genes more specific for each cardiac cell population. Indeed, Lb CBs datasets show that in early stage there is the enrichment of genes mostly involved in transcriptional regulation and RNA splicing and some of these genes (prp8 and prp38) are involved in cardiac development. In parallel, we compared our TRAP-Seq dataset in the cardiac system with the TRAP-seqon muscle cells, and identified close to 90 genes that present cardiac or muscular specific isoforms. It is known that the alternative splicing, by increasing proteins diversity, contributes to the acquisition of specific cell properties. Furthermore, some cardiomyopathies are associated to defects in the alternative splicing of genes encoding sarcomeric proteins that we found in our dataset such as Tropomyosin and Zasp52. With this project, we have identified new actors of collective cardioblast migration and a set of genes with potential role in the acquisition of individual properties of Tin and Lbcardiac cells or of specific type of muscle tissue. We hope that our data could provide new insights into the genetic control of vertebrate cardiogenesis and into etiology of cardiac diseases
Arthurs, Christopher J. "Efficient simulation of cardiac electrical propagation using adaptive high-order finite elements." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ad31f06f-c4ed-4c48-b978-1ef3b12fe7a1.
Celebi, Hatice. "Structural And Functional Analysis Of Henry James." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/597/index.pdf.
s scheme she draws in her book Narrative Fiction. The functional analysis to show the consequent changes in meaning and emphasis, on the other hand, will rely on Roland Barthes&rsquo
s theory of functions he discusses in his article &ldquo
Structural Analysis of Narratives&rdquo
. In order to explore the narrative structure of The Portrait of A Lady, this thesis will examine story, characterization, time and focalization and demonstrate the techniques Henry James uses in narration. In the functional analysis of the novel, on the other hand, the functions of the units discussed in the story and the characterization will be compared to the functions of the same units that are transferred to the adaptation of the novel to reveal how the meaning and emphasis of the novel changes.
Giardini, Francesco. "Morpho-functional investigation of cardiac remodeling in an arrhythmogenic mouse model by advanced optical methods." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1211015.
Yamamuro, Masaki. "Cardiac functional analysis with multi-detector row CT and segmental reconstruction algorithm : comparison with echocardiography, SPECT and MR imaging." Kyoto University, 2006. http://hdl.handle.net/2433/143834.
Yang, Yingyu. "Analyse automatique de la fonction cardiaque par intelligence artificielle : approche multimodale pour un dispositif d'échocardiographie portable." Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://www.theses.fr/2023COAZ4107.
According to the 2023 annual report of the World Heart Federation, cardiovascular diseases (CVD) accounted for nearly one third of all global deaths in 2021. Compared to high-income countries, more than 80% of CVD deaths occurred in low and middle-income countries. The inequitable distribution of CVD diagnosis and treatment resources still remains unresolved. In the face of this challenge, affordable point-of-care ultrasound (POCUS) devices demonstrate significant potential to improve the diagnosis of CVDs. Furthermore, by taking advantage of artificial intelligence (AI)-based tools, POCUS enables non-experts to help, thus largely improving the access to care, especially in less-served regions.The objective of this thesis is to develop robust and automatic algorithms to analyse cardiac function for POCUS devices, with a focus on echocardiography (ECHO) and electrocardiogram (ECG). Our first goal is to obtain explainable cardiac features from each single modality respectively. Our second goal is to explore a multi-modal approach by combining ECHO and ECG data.We start by presenting two novel deep learning (DL) frameworks for echocardiography segmentation and motion estimation tasks, respectively. By incorporating shape prior and motion prior into DL models, we demonstrate through extensive experiments that such prior can help improve the accuracy and generalises well on different unseen datasets. Furthermore, we are able to extract left ventricle ejection fraction (LVEF), global longitudinal strain (GLS) and other useful indices for myocardial infarction (MI) detection.Next, we propose an explainable DL model for unsupervised electrocardiogram decomposition. This model can extract interpretable information related to different ECG subwaves without manual annotation. We further apply those parameters to a linear classifier for myocardial infarction detection, which showed good generalisation across different datasets.Finally, we combine data from both modalities together for trustworthy multi-modal classification. Our approach employs decision-level fusion with uncertainty, allowing training with unpaired multi-modal data. We further evaluate the trained model using paired multi-modal data, showcasing the potential of multi-modal MI detection to surpass that from a single modality.Overall, our proposed robust and generalisable algorithms for ECHO and ECG analysis demonstrate significant potential for portable cardiac function analysis. We anticipate that our novel framework could be further validated using real-world portable devices. We envision that such advanced integrative tools may significantly contribute towards better identification of CVD patients
Jaquet, Clara. "Vers la simulation de perfusion du myocarde à partir d'image tomographique scanner." Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC1117/document.
Recent advances in medical image computing have allowed automatedsystems to closely assist physicians in patient therapy. Computationaland personalized patient models benefit diagnosis, prognosisand treatment planning, with a decreased risk for the patient,as well as potentially lower cost. HeartFlow Inc. is a successfull exampleof a company providing such a service in the cardiovascularcontext. Based on patient-specific vascular model extracted from XrayCT images, they identify functionally significant disease in largecoronary arteries. Their combined anatomical and functional analysisis nonetheless limited by the image resolution. At the downstreamscale, a functional exam called Myocardium Perfusion Imaging (MPI)highlights myocardium regions with blood flow deficit. However,MPI does not functionally relate perfusion to the upstream coronarydisease.The goal of our project is to build the functional bridge betweencoronary and myocardium, by extrapolating the functional analysisfrom large coronary toward the capillary bed. This objective requiresextension from the coronary model down to the microvasculaturecombined with a functional analysis leading to the myocardium compartment.We expand a tree generation method subjected to functional principles,named Constrained Constructive Optimization, to generate multiplecompeting vascular trees. The algorithm simulates angiogenesisunder vascular volume minimization with flow-related and geometricalconstraints, adapting the simultaneous tree growths to patientpriors. This method provides a hybrid image-based and synthetic geometricmodel, starting from segmented epicardium coronary downto synthetic arterioles, filling the left ventricle myocardium.We then build a multiscale functional analysis pipeline to allowblood flow simulation from the coronaries to the myocardium. Thisis achieved with a 1D coronary model compatible with the hybridvasculature, and a spatial blood flow distribution analysis of the terminalsegments. The latter is performed using a similar nomenclatureto MPI, to enable patient-specific comparison with functional groundtruthdata.We connected the vascular anatomy to blood flow distribution inthe myocardium on several patient datasets. This multiscale frameworkpoints out several leads to refine the vascular network generationand fluid simulation methods. This patient-specific anatomicaland functional extrapolation is a first gateway toward myocardiumperfusion from X-ray CT data. Building such personalized computational model of patient could potentially help investigating cardiovascularcomplex physio-pathology, and, finally, improve the patientcare
Patout, Maxime. "Evaluation des techniques pour la prise en charge diagnostique et thérapeutique de l'insuffisance respiratoire chronique A Randomized controlled trial on the effect of needle gauge on the pain and anxiety experienced during radial arterial puncture Long term survival following initiation of home non-invasive ventilation : a European study Neural respiratory drive predicts long-term outcome following admission for exacerbation of COPD : a post hoc analysis Neural respiratory drive and cardiac function in patients with obesity hypoventilation syndrome following initiation of non-invasive ventilation Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up a pilot randomised clinical trial Chronic ventilator service Step-down from non-invasive ventilation to continuous positive airway pressure : a better phenotyping is required AVAPS-AE versus ST mode : a randomized controlled trial in patients with obesity hypoventilation syndrome Technological advances in home non-invasive ventilation monitoring : reliability of data and effect on patient outcomes Efficacy of a home discharge care bundle after acute exacerbation of COPD Prediction of severe acute exacerbation using changes in breathing pattern of COPD patients on home noninvasive ventilation Charasteristics and outcome of patients set up on high-flow oxygen therapy at home Trial of portable continuous positive airway pressure for the management of tracheobronchomalacia." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR115.
Single-organ respiratory failure defines chronic respiratory failure. Obesity hypoventilation syndrome is the main cause of chronic respiratory failure and occurs in 4 to 5% of obese patients. Chronic respiratory failure is also the end-stage evolution of chronic obstructive pulmonary disease that has a prevalence of 6 to 8% in the adult population. The incidence of these diseases increases so does the incidence of chronic respiratory failure. In this thesis, we will evaluate novel diagnostic and therapeutic modalities that could improve the care of patients with chronic respiratory failure. Regarding diagnostic modalities, we have seen that evaluating the work of breathing with surface parasternal electromyography was an independent prognostic marker in patients with chronic obstructive pulmonary disease. We have also seen that it was a relevant tool to predict the clinicalefficacy and compliance to home non-invasive ventilation. Regarding therapeutic modalities, we have shown that the use of a semi-automatic mode of non-invasive ventilation had the same efficacy of a standard mode with a shorter length of stay for its setup. We have shown the relevance and feasibility of the use of high-flow oxygen therapy in the home setting whilst it was only used in intensive care units. Finally, we have shown the benefits of continuous positive airway pressure during exertion in patients with tracheobronchomalacia. Regarding patients’ follow-up, we have shown that the use of data from built-in software could predict the onset of a severe exacerbation of chronic obstructive pulmonary disease. However, we also show that the implementation of tele-medicine in patients with chronic respiratory failure cannot be included in daily clinical practice yet. In this thesis, we have identified novel physiological tools, novel ways to administer treatments and novel follow-up tools that can improve the management of patients with chronic respiratory failure
Lin, Chien-Chung, and 林建仲. "Motion Analysis and Assessment of Cardiac Function for Cardiac Images." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/2uhv85.
元智大學
資訊管理學系
104
This thesis proposes a series of methods in analyzing cardiac motion sequences. It is helpful to assist the cardiologist to analyze the medical images for further diagnosis. Coronary angiogram is one of the most valid methods for diagnosing the presence of coronary artery disease. Therefore, we propose a method to select the optimum phase from the image sequence. The optimum phases were selected by evaluating the correlation coefficients with minimum inconsistency of motion in the selected data. The result of the optimum image phase selection shows that the automatically determined phases yield the optimum image quality. To achieve the purpose of providing accurate information in coronary artery images, an algorithm to extract the skeletons and borders of coronary arteries in digitalized angiograms automatically is also proposed. Based on the optimum image, we develop a combination of fragment strategy and tubular enhancement to figure out the vessel structure clearly. Cardiac wall motion plays an important role in the analysis and interpretation of various kinds of cardiac diseases. However, it is difficult to find the initial contour of cardiac boundary and produce an accurate motion flow field at motion boundaries. In this study, we propose a novel and non-iterative approach to segment the boundaries in motion images based on voting processes for catheterization angiocardiography. A voting process is first used to enforce the smoothness of motion and determine an estimation of pixel velocities, motion regions and boundaries. For the purpose of locally defining a boundary tensor field, boundary estimation is combined with intensity information from the original images. Correct velocities are computed for the pixels near boundaries, as they are reassigned to different regions. Furthermore, we propose a computer aided diagnosis/detection system for cardiac motion analysis of catheterization ventriculography. The purpose of this method is to develop a computerized system which helps physicians and radiologists to automatically predict the presence of heart disease as early as possible. The adaptive ellipse active contour model is used to refine the contours. Motion analysis of cardiac are performed according to the extracted contours to form the motion vector field by Empirical Mode Decomposition (EMD) method. The results of motion detection are displayed in the formats of motion vector fields and Doppler color display. The combination of quantitative cardiac motion analysis obtained from cardiac images enable the clinician to determine whether there exists a heart disease and therefore may need treatment. The purpose of this thesis is to make use of image information to assistant the diagnosis. Experiment results show that physicians can use the proposed solid model for process of evaluation and planning before the surgeries to promote the efficiency of diagnosis, medical treatment qualities and reduce the waste of medical resource.
Yang, Shih-Yu, and 楊詩郁. "Motion Analysis and Assessment of Cardiac Function in Catheterization Ventriculography." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/04623345291203615943.
元智大學
資訊管理學系
98
This study propose a computer-aided system to provide the motion analysis and assessment of cardiac function in catheterization ventriculography. First, we use the block matching method to segment the coarse contour of left ventricular region. Then, morphological operations were used to refine the contour. Secondly, a two step fuzzy logic system was used to identify the direction of heart motion. The Doppler ultrasonography representation was used to present a more intuitive and objective interpretation of cardiac information. Finally, some of the parameters such as Ejection Fraction and slope variation of ventricular are used to evaluate the cardiac function. Experimental results show that the proposed method can provide an effective motion analysis and assessment of cardiac function in catheterization ventriculography. Meanwhile, it can be further as the computer aided diagnosis system (CAD) for differential diagnosis in the future.
Liao, Fang-Tsu, and 廖芳足. "Cardiac function analysis of angiotensin-converting enzyme-related (ACER) in Drosophila melanogaster." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69942220839949096941.
VanDusen, Nathan J. "Hand2 function within non-cardiomyocytes regulates cardiac morphogenesis and performance." Thesis, 2014. http://hdl.handle.net/1805/6170.
The heart is a complex organ that is composed of numerous cell types, which must integrate their programs for proper specification, differentiation, and cardiac morphogenesis. During cardiac development the basic helix-loop-helix transcription factor Hand2 is dynamically expressed within the endocardium and extra-cardiac lineages such as the epicardium, cardiac neural crest cells (cNCCs), and NCC derived components of the autonomic nervous system. To investigate Hand2 function within these populations we utilized multiple murine Hand2 Conditional Knockout (H2CKO) genetic models. These studies establish for the first time a functional requirement for Hand2 within the endocardium, as several distinct phenotypes including hypotrabeculation, tricuspid atresia, aberrant septation, and precocious coronary development are observed in endocardial H2CKOs. Molecular analyses reveal that endocardial Hand2 functions within the Notch signaling pathway to regulate expression of Nrg1, which encodes a crucial secreted growth factor. Furthermore, we demonstrate that Notch signaling regulates coronary angiogenesis via Hand2 mediated modulation of Vegf signaling. Hand2 is strongly expressed within midgestation NCC and endocardium derived cardiac cushion mesenchyme. To ascertain the function of Hand2 within these cells we employed the Periostin Cre (Postn-Cre), which marks cushion mesenchyme, a small subset of the epicardium, and components of the autonomic nervous system, to conditionally ablate Hand2. We find that Postn-Cre H2CKOs die shortly after birth despite a lack of cardiac structural defects. Gene expression analyses demonstrate that Postn-Cre ablates Hand2 from the adrenal medulla, causing downregulation of Dopamine Beta Hydroxylase (Dbh), a gene encoding a crucial catecholaminergic biosynthetic enzyme. Electrocardiograms demonstrate that 3-day postnatal Postn-Cre H2CKO pups exhibit significantly slower heart rates than control littermates. In conjunction with the aforementioned gene expression analyses, these results indicate that loss of Hand2 function within the adrenal medulla results in a catecholamine deficiency and subsequent heart failure.
Juric, Danijel. "A comparative serial analysis of cardiac sarcoplasmic reticulum function in rats subjected to pressure or volume overload." 2007. http://hdl.handle.net/1993/20502.
Cantor, Elliott J. F. "A comparative serial echocardiographic analysis of cardiac structure and function in rats subjected to pressure or volume overload." 2005. http://hdl.handle.net/1993/17957.
Chou, Hsiao-Hsuan, and 周曉璇. "The Analysis and Applications of Optical Flow in Cardiac Functions." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/57482256576176396762.
國立臺灣大學
電機工程研究所
84
The motion of the heart is very complicated. Understanding the wall motion of the left ventricle is especially important for analysizing the cardiac functions. Due to the development of imaging technology, it beomes easier to get the dynamic cardiac image sequence. If we can get the correct velocity information from the dynamic images, it will be helpful for the cardiac diagnosis and the heart function evalution. Optical flow is the velocity distribution of the patterns in image. With the optical flow method, we can acquire the magnitude and the direction of the velocity of each pixel in an image.We apply this method on dynamic Cardiac Magnetic Resonance Images (MRI) and Radionuclide Angiography images (RNA) , focusing on the wall motion of the left ventricle. From the optical flow we study, the complex motion pattern during the diastole and systole of a heart cycle can be observed and analyzed. In order to increase the precision, we use anisotropic diffusion and gaussian filters in space and time domain for smoothing the gray-levels in advance. A median filter is than applied on the velocity field . The velocity fields calculated from the optical flow method show many details of the heart motion. By tracing the locations of the points we interested, we can get useful physiological parameters, eg. ejection fraction(EF), peak filling rate(PFR), etc. Moreover, by calaulating the strain rate from the velocity field, one can tell the differences between the healthy and abnormal cardiac functions. Other mechanical parameters of the heart could be also derived displayed using this method noninvasively, which is not possible with traditional imaging techniques.
Bray, Mark-Anthony P. "Visualization and analysis of electrodynamic behavior during cardiac arrhythmias." 2003. http://etd.library.vanderbilt.edu/ETD-db/available/etd-03182003-110637/.
Andreopoulos, Alexander. "Statistical models of appearance for functional analysis of cardiac MRI /." 2005.
Typescript. Includes bibliographical references (leaves 160-166). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11736
Barakat, Amal Zohir Abo-Zeid. "Functional Analysis of Heat Shock Protein HSPA4." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B522-E.
von, Loesch Eckhart Thassilo. "Evaluation eines Echtzeit-Verfahrens in der kardialen Magnetresonanztomographie bei Patienten mit Herzrhytmusstörungen am Beispiel von Vorhofflimmern." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3DC8-6.