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Добірка наукової літератури з теми "Carbon Dots - Bio-medicine"

Автор: Grafiati

Опубліковано: 7 вересня 2023

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Статті в журналах з теми "Carbon Dots - Bio-medicine"

Baluta, Sylwia, Anna Lesiak, and Joanna Cabaj. "Simple and Cost-Effective Electrochemical Method for Norepinephrine Determination Based on Carbon Dots and Tyrosinase." Sensors 20, no. 16 (August 14, 2020): 4567. http://dx.doi.org/10.3390/s20164567.

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Although neurotransmitters are present in human serum at the nM level, any dysfunction of the catecholamines concentration may lead to numerous serious health problems. Due to this fact, rapid and sensitive catecholamines detection is extremely important in modern medicine. However, there is no device that would measure the concentration of these compounds in body fluids. The main goal of the present study is to design a simple as possible, cost-effective new biosensor-based system for the detection of neurotransmitters, using nontoxic reagents. The miniature Au-E biosensor was designed and constructed through the immobilization of tyrosinase on an electroactive layer of cysteamine and carbon nanoparticles covering the gold electrode. This sensing arrangement utilized the catalytic oxidation of norepinephrine (NE) to NE quinone, measured with voltammetric techniques: cyclic voltammetry and differential pulse voltammetry. The prepared bio-system exhibited good parameters: a broad linear range (1–200 μM), limit of detection equal to 196 nM, limit of quantification equal to 312 nM, and high selectivity and sensitivity. It is noteworthy that described method was successfully applied for NE determination in real samples.

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Pham, Son H., Yonghyun Choi, and Jonghoon Choi. "Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery." Pharmaceutics 12, no. 7 (July 4, 2020): 630. http://dx.doi.org/10.3390/pharmaceutics12070630.

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The new era of nanotechnology has produced advanced nanomaterials applicable to various fields of medicine, including diagnostic bio-imaging, chemotherapy, targeted drug delivery, and biosensors. Various materials are formed into nanoparticles, such as gold nanomaterials, carbon quantum dots, and liposomes. The nanomaterials have been functionalized and widely used because they are biocompatible and easy to design and prepare. This review mainly focuses on nanomaterials responsive to the external stimuli used in drug-delivery systems. To overcome the drawbacks of conventional therapeutics to a tumor, the dual- and multi-responsive behaviors of nanoparticles have been harnessed to improve efficiency from a drug delivery point of view. Issues and future research related to these nanomaterial-based stimuli sensitivities and the scope of stimuli-responsive systems for nanomedicine applications are discussed.

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Gupta, Sanju, Tyler Smith, Alexander Banaszak, and John Boeckl. "Graphene Quantum Dots Electrochemistry and Development of Ultrasensitive Enzymatic Glucose Sensor." MRS Advances 3, no. 15-16 (2018): 831–47. http://dx.doi.org/10.1557/adv.2018.324.

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AbstractGraphene quantum dots (GQDs) - zero-dimensional materials - are sheets of a few nanometers in lateral dimension and exhibit quantum confinement and edge site effects where sp2-bonded carbon nanocore surrounded with edged plane functional moieties is promising as advanced electroactive sensing platforms. In this work, GQDs are synthesized by solvothermal and hydrothermal techniques, with optimal size of 5 nm. Their potential in fundamental (direct electron transfer) and applied (enzymatic glucose biosensor) electrochemistry are demonstrated. Glucose oxidase (GOx) immobilized on glassy carbon (GC) electrodes modified with GQDs are investigated by means of cyclic voltammetry, differential pulse voltammetry, and amperometry. Well-defined quasi-reversible redox peaks observed under various electrochemical parameters helped to determine diffusion coefficient (D) and first-order electron transfer rate (kET). The cyclic voltammetry curves showed homogeneous ion transport for GQD with D ranging between 8.45 × 10−9 m2 s−1 and 3 × 10−8 m2 s−1 following GO < rGO < GQD < GQD (with FcMeOH as redox probe) < GOx/rGO < GOx/GO < HRP/GQDs < GOx/GQDs. The developed GOx-GQDs biosensor responds efficiently and linearly to the presence of glucose over concentrations ranging 10 μM and 3 mM with limit of detection 1.35 μM and sensitivity 0.00769 μA μM−1·cm−2 as compared with rGO (0.025 μA μM−1 cm−2, 4.16 μM) and GO (0.064 μA μM−1 cm−2, 4.82 μM) nanosheets. The high performance and stability of GQDs is attributed to sufficiently large surface-to-volume ratio, excellent biocompatibility, abundant hydrophilic edge site density, and partially hydrophobic planar sites that favors GOx adsorption on the electrode surface and versatile architectures to ensure rapid charge transfer and electron/ion conduction (<10 ms). We also carried out similar studies with other enzymatic protein biomolecules on electrode surfaces prepared from GQD precursors for electrochemical comparison, thus opening up potential sensing applications in medicine as well as bio-nanotechnology.

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Kumari, Manisha, Ganga Ram Chaudhary, Savita Chaudhary, Ahmad Umar, Sheikh Akbar, and Sotirios Baskoutas. "Bio-Derived Fluorescent Carbon Dots: Synthesis, Properties and Applications." Molecules 27, no. 16 (August 21, 2022): 5329. http://dx.doi.org/10.3390/molecules27165329.

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The transformation of biowaste into products with added value offers a lucrative role in nation-building. The current work describes the synthesis of highly water-soluble, luminous carbon quantum dots (CQDs) in the size range of 5–10 nm from discarded rice straw. The small spherical CQDs that were formed had outstanding optical and luminescent qualities as well as good photostabilities. By performing quantitative multi-assay tests that included antioxidant activities, in vitro stability and colloidal assay investigations as a function of different CQD concentrations, the biocompatibility of CQDs was evaluated. To clearly visualize the type of surface defects and emissive states in produced CQDs, excitation-dependent fluorescence emission experiments have also been carried out. The “waste-to-wealth” strategy that has been devised is a successful step toward the quick and accurate detection of Cu2+ ion in aqueous conditions. The fluorescence-quenching behavior has specified the concentration dependency of the developed sensor in the range of 50 μM to 10 nM, with detection limit value of 0.31 nM. The main advantage of the current research is that it offers a more environmentally friendly, economically viable and scaled-up synthesis of toxicologically screened CQDs for the quick fluorescence detection of Cu2+ ions and opens up new possibilities in wastewater management.

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Wang, Haitao, Jingran Bi, Bei-Wei Zhu, and Mingqian Tan. "Multicolorful Carbon Dots for Tumor Theranostics." Current Medicinal Chemistry 25, no. 25 (August 30, 2018): 2894–909. http://dx.doi.org/10.2174/0929867324666170316110810.

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Background: Cancer is a great threat of human health worldwide due to the uncontrollable spread of malignant cells throughout the body. Accurate diagnosis and targeted therapy approaches are critical factors for cancer treatment. Combination of therapeutic and diagnostic agents in a single nanocarrier enables to simultaneously monitor the cancer progression and tune disease therapy with minimum side effect. Objective: Carbon dots are a novel class of small fluorescence carbon nanostructures with size less than 10 nm at least in one dimension, which exhibit excellent optical properties, larger surface area to volume ratio and low toxicity. The unique properties of carbon dots make it as an ideal carrier for incorporation of cancer targeting moieties, bio-imaging agents and antineoplastic agents in one delivery system. Methods: An literature search was conducted using Web of Science to find out articles related to carbon dots and tumor theranostics. Results: Numerous applications of carbon dots in cancer theranostics have been reported during the past 10 years. This review introduces a brief history and basic fluorescent properties of carbon dots, and then discusses synthesis strategies and applications of carbon dots in biological imaging, targeted anti-cancer drug delivery, photodynamic therapy, photothermal therapy as well as gene delivery for cancer theranostics. Future directions of carbon dots in cancer theranostics are also highlighted.

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Zhao, Yafei, Lan Mu, Yongxiang Su, Liyi Shi, and Xin Feng. "Pt–Ni nanoframes functionalized with carbon dots: an emerging class of bio-nanoplatforms." Journal of Materials Chemistry B 5, no. 31 (2017): 6233–36. http://dx.doi.org/10.1039/c7tb01678f.

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Yao, Hanchun, Weiwei Zhao, Suge Zhang, Xiaofang Guo, Ying Li, and Bin Du. "Dual-functional carbon dot-labeled heavy-chain ferritin for self-targeting bio-imaging and chemo-photodynamic therapy." Journal of Materials Chemistry B 6, no. 19 (2018): 3107–15. http://dx.doi.org/10.1039/c8tb00118a.

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Kaushal, Gaytri, Baljinder Kaur, Pankaj Kumar, Meenakshi Dhiman, and Partha Khanra. "A Short Review: Synthesis Methods and Application of Biomolecule Derived Graphene Quantum-Dots." ECS Transactions 107, no. 1 (April 24, 2022): 6297–308. http://dx.doi.org/10.1149/10701.6297ecst.

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Among the carbon allotrope, graphene quantum-dots (GQDs) have been attracted tremendous attention due to unique physicochemical properties, such as high surface area, sustainable photoluminecent properties, excellent electrochemical properties, good biocompatibility, unique drag delivery capacity, etc. The major source of GQDs are carbonaceous materials and hydrocarbon based bio-resources. Interestingly, this short review focuses on synthesis methods of GQDs from biomolecules. Basically, biomolecules consisted with multiple bonded carbon with oxygen, hydrogen, and oxyhydrogen moieties. By chemical reactions it will converted into GQDs by removal of oxyhydrogen moieties by different routes of preparation and applicable for many advance applications, mainly in optoelectronics applications and biomedical applications. Moreover, the GQDs are capable for many other applications, such as energy storage and chemical sensing. However, we have focus on the bio-derived GQDs by different methods and reported applications.

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Fauziyah, Nur Aini. "A brief review of C-Dots preparation using top-down and bottom-up approaches." International Journal of Eco-Innovation in Science and Engineering 3, no. 01 (May 25, 2022): 25–29. http://dx.doi.org/10.33005/ijeise.v3i01.54.

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This review paper aimed to reveal several methods that have been used in the preparation of carbon dots (C-Dots). C-Dots were principal to be studied because they have luminous properties that can be used in photocatalyst processes, heavy metal sensors, glowing paints, and nanoparticles for biomedical applications such as bio-tagging. The methods that have been developed were also varied using the two principal approaches, i.e., top-down and bottom-up. Here, we tried to reveal the arc-discharge, laser ablation techniques for top-down approaches, while simple heating methods (simple hydrothermal methods), and microwave for bottom-up. Furthermore, the microwave method was excellent because of the vibration process which caused the carbon chains to undergo rearrangement so that the result was not much reducing the water content in the solution.

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Jacinth Gracia, Kirubaharan Daphne, Seth Sheeba Thavamani, Thomas Peter Amaladhas, Sandhanasamy Devanesan, Mukhtar Ahmed, and Maruthamuthu Murali Kannan. "Valorisation of bio-derived fluorescent carbon dots for metal sensing, DNA binding and bioimaging." Chemosphere 298 (July 2022): 134128. http://dx.doi.org/10.1016/j.chemosphere.2022.134128.

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Частини книг з теми "Carbon Dots - Bio-medicine"

Sadegh Hassani, S., M. Daraee, S. H. Navazani, and F. Rahimi. "Carbon-based Quantum Dots from Food Waste: Synthesis to Application in Food Safety." In Quantum Dots in Bioanalytical Chemistry and Medicine, 275–306. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781839169564-00275.

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Food safety is a major global concern; the development of methods for detecting contaminants in food ingredients and additives is of paramount importance. Nanotechnology shows excellent potential for improving food quality and safety. Carbon-based quantum dots (CQDs) are nanoparticles (NPs) whose unique properties – including their small size, useful optical properties, low toxicity, and chemical inertness – make them especially suitable for use in this field. Biocompatible CQDs can be produced from waste materials using green synthesis procedures and used in a variety of food safety applications, including detection (e.g., pathogenic bacteria, antibiotics, additives, colorants), bio/nano-sensing, and wastewater disinfection. In this chapter, we will discuss the synthesis, characterization, and properties of CQDs and their applications in food safety and the food industry more broadly.

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