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Статті в журналах з теми "Cancer, p53, lncRNA, non-coding RNA"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Su, Tong, Bobby Kong, Calvin Huang, Jonathan Zhu, and Colleen McHugh. "Abstract 1533: Long non-coding RNA control of cancer cell growth." Cancer Research 82, no. 12_Supplement (2022): 1533. http://dx.doi.org/10.1158/1538-7445.am2022-1533.

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Abstract Long non-coding RNAs (lncRNAs) are involved in controlling regulatory networks critical for gene expression, cellular growth, and development. Altered expression of lncRNAs are associated with tumor progression in multiple types of human cancers, but the mechanisms by which lncRNAs may control growth and proliferation in cancer cells remain unknown in most cases. Development of interventions targeting non-coding RNA regulation of cell growth would open new avenues for cancer treatment. To identify growth regulatory pathways controlled by non-coding RNAs, we used proteomics and genomic

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2

Cao, Yu, Deliang Cao, and Hongyan Ling. "The novel long non-coding RNA PANCR: A p53 activator and potential breast cancer biomarkers." Journal of Clinical Oncology 35, no. 15_suppl (2017): e23016-e23016. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23016.

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e23016 Background: Long non-coding RNAs (LncRNAs) may serve as a biomarker and potential therapeutic target of cancers. Chromosome 16q22.1 is frequently deleted in breast cancer and may contribute to breast carcinogenesis by inactivation of tumor suppressor genes. This study characterized a new LncRNA tumor suppressor in this region, named p53 activating non-coding RNA (PANCR). This LncRNA consists of 1.5kb in length. Methods: Quantitative real-time PCR was used for examine the PANCR expression in breast cancer tissues. RNA-pull down and RNA-Immunopreicitation were used to analyze PANCR target

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3

Zhao, Dongyan, Xizhen Sun, Sidan Long, and Shukun Yao. "An autophagy-related long non-coding RNA signature for patients with colorectal cancer." Physiology International 108, no. 2 (2021): 202–20. http://dx.doi.org/10.1556/2060.2021.00125.

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AbstractAimLong non-coding RNAs (lncRNAs) have been identified to regulate cancers by controlling the process of autophagy and by mediating the post-transcriptional and transcriptional regulation of autophagy-related genes. This study aimed to investigate the potential prognostic role of autophagy-associated lncRNAs in colorectal cancer (CRC) patients.MethodsLncRNA expression profiles and the corresponding clinical information of CRC patients were collected from The Cancer Genome Atlas (TCGA) database. Based on the TCGA dataset, autophagy-related lncRNAs were identified by Pearson correlation

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4

Bareja, Chanchal, Apoorva Uboveja, and Daman Saluja. "Abstract 1560: Elucidating the differential regulation of novel long non coding RNAs and their mechanism of action in p73 dependent manner." Cancer Research 82, no. 12_Supplement (2022): 1560. http://dx.doi.org/10.1158/1538-7445.am2022-1560.

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Abstract INTRODUCTION: The p53 tumor suppressor family is classically activated after DNA damage and plays a central role in cell fate decisions. Although, the p53 family activates many of the same genes in response to DNA damage, p73 plays distinct biological functions in development and metastasis. It is likely that p73 activates a unique transcriptional network which is critical for its anti-metastatic and anti-invasive action. Long non-coding RNAs (lncRNAs) are a class of mRNA-like transcripts longer than 200 nucleotides. They lack protein-coding ability and are believed to be involved in

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5

Wang, Li, Zhenhong Chen, Li An, et al. "Analysis of Long Non-Coding RNA Expression Profiles in Non-Small Cell Lung Cancer." Cellular Physiology and Biochemistry 38, no. 6 (2016): 2389–400. http://dx.doi.org/10.1159/000445591.

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Background/Aims: Long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. However, the role of lncRNA expression in human Non-small cell lung cancer (NSCLC) biology, prognosis and molecular classification remains unknown. Methods: We established the IncRNA profile in NSCLC by re-annotation of microarrays from the Gene expression omnibus database. Quantitative real-time PCR was used to determine expression of LINC00342. Results: 6066 differentially expressed IncRNAs were identified and we found a novel IncRNA, LINC00342 was significantly up-regulated in NSCLC tissues compared wit

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6

Zhou, Yaodong, and Qing Xia. "LncRNA H19 Promotes Lung Adenocarcinoma Progression via Binding to Mutant p53 R175H." Cancers 14, no. 18 (2022): 4486. http://dx.doi.org/10.3390/cancers14184486.

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Background: Accumulating data suggest that long non-coding RNA (lncRNA) H19 and p53are closely related to the prognosis of lung cancer. This study aims to analyze the association and interaction betweenH19 and mutant p53 R175H in lung adenocarcinoma (LAC). Methods: Mutant-type (Mt) p53 R175H was assessed by using RT-PCR in LAC cells and 100 cases of LAC tissue samples for association with H19 expression. Western blot, RNA-pull down, immunoprecipitation-Western blot and animal experiments were used to evaluate the interaction between H19 and mtp53. Results: Mtp53 R175H and H19 were over-express

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7

Toraih, Eman A., Aya El-Wazir, Mohammad H. Hussein, et al. "Expression of long intergenic non-coding RNA, regulator of reprogramming, and its prognostic value in patients with glioblastoma." International Journal of Biological Markers 34, no. 1 (2019): 69–79. http://dx.doi.org/10.1177/1724600818814459.

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Background: Long intergenic non-coding RNA, regulator of reprogramming ( LINC-ROR) is a newly identified cytoplasmic long non-coding RNA (lncRNA), which has been found to be dysregulated in different cancers. The present work aimed to quantify LINC-ROR expression profile and assess the tumor proteins p53 and caspase 3 expressions in glioblastoma tissue specimens compared to non-cancer tissues, and to correlate these expression levels with the available clinicopathological and survival data. Methods: LINC-ROR relative expression in 57 glioblastoma cancer tissues and 10 non-cancer tissues was qu

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8

Chen, Qiongyun, Xiaoqing Huang, Xuan Dong, Jingtong Wu, Fei Teng, and Hongzhi Xu. "Long non-coding RNA ERICH3-AS1 is an unfavorable prognostic factor for gastric cancer." PeerJ 8 (January 28, 2020): e8050. http://dx.doi.org/10.7717/peerj.8050.

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Long non-coding RNAs (lncRNAs) play important roles in gastric cancer (GC), but the mechanism is not fully clear. ERICH3-AS1 (ERICH3 antisense RNA1) is affiliated with the non-coding RNA class which has proven to be involved in the prognostic of GC, but the function of ERICH3-AS1 is still unclear. In this study, we aim to explore the potential function of ERICH3-AS1 in the development of GC and analyze the prognostic role of ERICH3-AS1 in GC. We found that the lncRNA ERICH3-AS1 was significantly up-regulated in GC tissues in the analysis of The Cancer Genome Atlas (TCGA) data; the Kaplan-Meier

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9

Lai, Xiaojia Zuo, Xintong Yang, et al. "PATH-03. FERROPTOSIS-RELATED LONG NON-CODING RNA SIGNATURES PREDICT PROGNOSIS IN PATIENTS WITH GLIOMA." Neuro-Oncology 23, Supplement_6 (2021): vi115. http://dx.doi.org/10.1093/neuonc/noab196.456.

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Abstract Ferroptosis, with iron-dependent and ROS-dependent, is a novel type of cell death in a variety of diseases and some studies confirmed that ferroptosis-related lncRNAs are involved in the occurrence and development of several cancers. However, the ferroptosis-related lncRNA in the role of gliomas is unclear. Here, we constructed a prognostic scoring model of ferroptosis-related lncRNAs in gliomas. Data were downloaded from the Chinese glioma genome atlas (CGGA), the cancer genome atlas, and FerrDb database. In this study, we found 1051 lncRNAs associated with ferroptosis by Spearman's

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10

Pal, Sonali, Manoj Garg, and Amit Kumar Pandey. "Deciphering the Mounting Complexity of the p53 Regulatory Network in Correlation to Long Non-Coding RNAs (lncRNAs) in Ovarian Cancer." Cells 9, no. 3 (2020): 527. http://dx.doi.org/10.3390/cells9030527.

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Amongst the various gynecological malignancies affecting female health globally, ovarian cancer is one of the predominant and lethal among all. The identification and functional characterization of long non-coding RNAs (lncRNAs) are made possible with the advent of RNA-seq and the advancement of computational logarithm in understanding human disease biology. LncRNAs can interact with deoxyribonucleic acid (DNA), ribonucleic acid (RNA), proteins and their combinations. Moreover, lncRNAs regulate orchestra of diverse functions including chromatin organization and transcriptional and post-transcr

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11

Di Agostino, Silvia. "The Impact of Mutant p53 in the Non-Coding RNA World." Biomolecules 10, no. 3 (2020): 472. http://dx.doi.org/10.3390/biom10030472.

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Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), micro RNAs (miRNAs), and extracellular RNAs (exRNAs) are new groups of RNAs with regulation activities that have low or no protein-coding ability. Emerging evidence suggests that deregulated expression of these non-coding RNAs is associated with the induction and progression of diverse tumors throughout epigenetic, transcriptional, and post-transcriptional modifications. A consistent number of non-coding RNAs (ncRNAs) has been shown to be regulated by p53, the most important tumor suppressor of the cells frequently mutated in human canc

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12

Chen, Zihao, Hongping Ju, Shan Yu, et al. "Prader–Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p." Clinical Science 132, no. 9 (2018): 1003–19. http://dx.doi.org/10.1042/cs20171588.

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Gastric cancer (GC) is one of the major global health problems, especially in Asia. Nowadays, long non-coding RNA (lncRNA) has gained significant attention in the current research climate such as carcinogenesis. This research desires to explore the mechanism of Prader–Willi region non-protein coding RNA 1 (PWRN1) on regulating GC process. Differentially expressed lncRNAs in GC tissues were screened out through microarray analysis. The RNA and protein expression level were detected by quantitative real-time PCR (qRT-PCR) and Western blot. Cell proliferation, apoptosis rate, metastasis abilities

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13

Zhang, Ying, Feng Yuan, Cassandra Grello, et al. "CSIG-07. GAIN-OF-FUNCTION MUTANT P53 REGULATES LONG-NONCODING RNAS IN GLIOBLASTOMA." Neuro-Oncology 24, Supplement_7 (2022): vii39—vii40. http://dx.doi.org/10.1093/neuonc/noac209.156.

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Abstract P53 is frequently mutated in most human cancers, including glioblastoma (GBM). Many p53 mutants acquire gain-of-function oncogenic effects through only partially understood mechanisms. To investigate the role of gain-of-function mutant p53 (MUT-p53) in GBM, we performed ChIP-seq of wildtype p53 (WT-p53) and MUT-p53 GBM cell lines. Among 2834 unique peaks reads in MUT-p53 cells, we found 242 long non-coding RNAs (lncRNAs) with up to 145 fold enrichment relative to WT-p53. LncRNAs regulate many molecular and cellular functions, including gene expression, cell proliferation, death, cance

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14

Lee, Yoonsung, and Young-Seuk Bae. "Long Non-Coding RNA KCNQ1OT1 Regulates Protein Kinase CK2 Via miR-760 in Senescence and Calorie Restriction." International Journal of Molecular Sciences 23, no. 3 (2022): 1888. http://dx.doi.org/10.3390/ijms23031888.

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Long non-coding RNAs (lncRNAs) play important biological roles. Here, the roles of the lncRNA KCNQ1OT1 in cellular senescence and calorie restriction were determined. KCNQ1OT1 knockdown mediated various senescence markers (increased senescence-associated β-galactosidase staining, the p53-p21Cip1/WAF1 pathway, H3K9 trimethylation, and expression of the senescence-associated secretory phenotype) and reactive oxygen species generation via CK2α downregulation in human cancer HCT116 and MCF-7 cells. Additionally, KCNQ1OT1 was downregulated during replicative senescence, and its silencing induced se

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15

Saluja, Daman, Apoorva Uboveja, Yatendra kumar Satija, and Fouzia Siraj. "Abstract 1552: Deciphering the mechanism of action of Long non-coding RNA fer1l4 in the suppression of invasion, migration and metastasis of colon cell carcinoma." Cancer Research 82, no. 12_Supplement (2022): 1552. http://dx.doi.org/10.1158/1538-7445.am2022-1552.

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Abstract Introduction: p73 transcription factor belongs to the p53 tumor suppressor family. Recent studies revealed that p73 wields its tumor suppressor properties by inhibiting metastasis. Although the literature on the p73 transcriptional circuit has chiefly concentrated on protein-coding genes, it has been progressively pointed out that p73 is also able to transcriptionally modulate non-coding RNA (ncRNA) members. These involve microRNAs (miRNAs) and many p53-regulated long non-coding RNAs (lncRNAs). Methods: Identification of p73 binding sites in the FER1L4 promoter region was made by JASP

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16

Su, Pengxiao, Fengqin Wang, Bin Qi, Ting Wang, and Shaobo Zhang. "P53 Regulation-Association Long Non-Coding RNA (LncRNA PRAL) Inhibits Cell Proliferation by Regulation of P53 in Human Lung Cancer." Medical Science Monitor 23 (April 11, 2017): 1751–58. http://dx.doi.org/10.12659/msm.900205.

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17

Wang, Yanqiang, Huiling He, Wei Li, et al. "MYH9 binds to lncRNA genePTCSC2and regulatesFOXE1in the 9q22 thyroid cancer risk locus." Proceedings of the National Academy of Sciences 114, no. 3 (2017): 474–79. http://dx.doi.org/10.1073/pnas.1619917114.

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A locus on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of papillary thyroid carcinoma (PTC). The locus also comprises the forkhead box E1 (FOXE1) gene, which is implicated in thyroid development, and a long noncoding RNA (lncRNA) gene, papillary thyroid cancer susceptibility candidate 2 (PTCSC2). How these might interact is not known. Here we report thatPTCSC2binds myosin-9 (MYH9). In a bidirectional promoter shared byFOXE1andPTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed byPTCSC2, which acts as a suppressor. RNA knockdo

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18

Zhu, Kangle, Qingqing Wang, and Lian Wang. "Analysis of Competitive Endogenous RNA Regulatory Network of Exosomal Breast Cancer Based on exoRBase." Evolutionary Bioinformatics 18 (January 2022): 117693432211132. http://dx.doi.org/10.1177/11769343221113286.

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Objective: To construct a competitive endogenous RNA (ceRNA) regulatory network derived from exosomes of human breast cancer (BC) by using the exoRbase database, to explore the possible pathogenesis of BC, and to develop new targets for future diagnosis and treatment. Methods: The exosomal gene sequencing data of BC patients and normal controls were downloaded from the exoRbase database, and the expression profiles of exosomal mRNA, long non-coding RNA (lncRNA), and circular RNA (circRNA) were analyzed by using R language. Use Targetscan and miRanda database to jointly predict and differential

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19

Watanabe, Saki, Tsukasa Oda, Yuko Kuroda, et al. "Long Non-Coding RNA NEAT1 Is Upregulated By Heat Shock Factor 1 (HSF1) and Associated with Multiple Myeloma Progression." Blood 132, Supplement 1 (2018): 1904. http://dx.doi.org/10.1182/blood-2018-99-113720.

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Abstract Background and Aims: Recent transcriptome-wide analyses have revealed an overwhelming amount of transcribed but not translated non-coding RNAs capable of influencing diverse cellular processes, such as proliferation, apoptosis, and cellular damage response. Long non-coding RNA (lnc RNA), which are commonly defined as transcripts >200 nt in length, have emerged as a class of key regulatory RNA. LncRNA are deregulated in diverse human cancers and associated with disease progression, however little is available in multiple myeloma (MM). We have previously shown that lnc RNA MALAT1 was

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20

Song, Fang, and Fengshuang Li. "Long Non-Coding RNA F11-Antisense 1 (F11-AS1) Suppresses Ovarian Cancer Biological Activity by Regulating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)." Journal of Biomaterials and Tissue Engineering 11, no. 9 (2021): 1752–59. http://dx.doi.org/10.1166/jbt.2021.2632.

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Aim: To discuss F11-AS1’s effects and mechanisms in ovarian cancer development. Methods: Evaluating F11-AS1 expression by ISH assay and F11-AS1 mRNA level in difference cell lines by RT-qPCR assay. Using MTT, flow cytometry, transwell and wound healing assay to evaluate SKOV3 cell proliferation, cell apoptosis, invasion and migration. And using WB assay to measure PTEN, p-PI3K, AKT, P53 and MMP-9 proteins expressions. Results: F11-AS1 was significantly down-regulation with stage increasing in cancer tissues (P <0.01, respectively). With F11-AS1 transfection, the SKOV3 cell proliferation rat

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21

Lu, Xiyi, Chenjun Huang, Xuezhi He, et al. "A Novel Long Non-Coding RNA, SOX21-AS1, Indicates a Poor Prognosis and Promotes Lung Adenocarcinoma Proliferation." Cellular Physiology and Biochemistry 42, no. 5 (2017): 1857–69. http://dx.doi.org/10.1159/000479543.

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Background: In recent years, long non-coding RNAs (lncRNAs) have been shown to be a novel class of regulators of cancer biological processes. Although lncRNAs are dysregulated in numerous cancer types, limited data are available on the expression profiles and potential functions of lncRNAs in lung adenocarcinoma (LUAD). This study evaluated the expression and biological roles of lncRNA SOX21 antisense RNA 1 (SOX21-AS1) in LUAD. Methods: Quantitative reverse transcription PCR (qRT-PCR) was performed to detect the expression levels of SOX21-AS1 in 68 pairs of LUAD tissues and corresponding non-t

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22

Diaz-Beya, Marina, Alfons Navarro, Anna Cordeiro, et al. "Exploring the Expression Profile of Long Non-Coding RNA (lncRNA) in Different Acute Myeloid Leukemia (AML) Subtypes: t(8;16)(p11;p13)/MYST3-Crebbp AML Harbors a Distinctive Lncrna Signature." Blood 126, no. 23 (2015): 1397. http://dx.doi.org/10.1182/blood.v126.23.1397.1397.

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Abstract Introduction: Long non-coding RNAs (lncRNAs) have recently emerged as important actors in the regulation of multiple cellular processes including cancer. Acute myeloid leukemia (AML) is a heterogeneous disease; most of the main cytogenetic AML subgroups harbor a specific gene expression profile. AML with translocation t(8;16)(p11;p13) (t(8;16) AML) is a subtype with specific clinical and biological characteristics including a distinctive gene (Camós et al, Cancer Research 2006) and microRNA (Díaz-Beyá et al, Leukemia 2013) expression profile. In this translocation, MYST3 on chromosome

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23

Tao, Zijia, Yiqiao Zhao, and Xiaonan Chen. "Role of methyltransferase-like enzyme 3 and methyltransferase-like enzyme 14 in urological cancers." PeerJ 8 (July 22, 2020): e9589. http://dx.doi.org/10.7717/peerj.9589.

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N6-methyladenosine (m6A) modifications can be found in eukaryotic messenger RNA (mRNA), long non-coding RNA (lncRNA), and microRNA (miRNA). Several studies have demonstrated a close relationship between m6A modifications and cancer cells. Methyltransferase-like enzyme 3 (METTL3) and methyltransferase-like enzyme 14 (METTL14) are two major enzymes involved in m6A modifications that play vital roles in various cancers. However, the roles and regulatory mechanisms of METTL3 and METTL14 in urological cancers are largely unknown. In this review, we summarize the current research results for METTL3

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24

Yi, Shen, Ying Xiao-jiang, Li Zhen-jun, Li Gang, Xue Wu-jin, and Jie Wei-xia. "UCA1, a long noncoding RNA, promotes the proliferation of CRC cells via p53/p21 signaling." Open Life Sciences 11, no. 1 (2016): 206–10. http://dx.doi.org/10.1515/biol-2016-0027.

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AbstractObjectiveRecently, the role of long noncoding RNAs (lncRNAs) in human colorectal cancer (CRC) has been a subject of intense focus. We set out to determine the function of one lncRNA, termed urothelial carcinoma-associated 1 (UCA1) in CRC cell proliferation and its underlying mechanisms.MethodsQuantitative real-time PCR (qRT-PCR) was applied to detect the expression level of UCA1 in 50 pairs of CRC samples compared with non-tumor colon tissues. Cell growth was determined using the Cell Counting Kit-8 (CCK-8). Western blotting was carried out to analyze the related protein expression. Fl

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25

Baytak, Esra, Qiang Gong, Burcu Akman, Hongling Yuan, Wing C. Chan, and Can Küçük. "Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1." Tumor Biology 39, no. 5 (2017): 101042831770164. http://dx.doi.org/10.1177/1010428317701648.

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Natural killer/T-cell lymphoma is a rare but aggressive neoplasm with poor prognosis. Despite previous reports that showed potential tumor suppressors, such as PRDM1 or oncogenes associated with the etiology of this malignancy, the role of long non-coding RNAs in natural killer/T-cell lymphoma pathobiology has not been addressed to date. Here, we aim to identify cancer-associated dysregulated long non-coding RNAs and signaling pathways or biological processes associated with these long non-coding RNAs in natural killer/T-cell lymphoma cases and to identify the long non-coding RNAs transcriptio

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26

Ma, Zhonghua, Peng Peng, Jing Zhou, et al. "Long Non-Coding RNA SH3PXD2A-AS1 Promotes Cell Progression Partly Through Epigenetic Silencing P57 and KLF2 in Colorectal Cancer." Cellular Physiology and Biochemistry 46, no. 6 (2018): 2197–214. http://dx.doi.org/10.1159/000489589.

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Background/Aims: Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies worldwide. Current evidence has revealed the key roles of long non-coding RNAs (IncRNAs) in multiple cancers, including CRC. In this study we identified the lncRNA SH3PXD2A-AS1 as a novel molecule associated with CRC progression by analyzing the publicly available data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) assays were performed to examine the expression levels of SH3PXD2A-AS1 in CRC tissue sampl

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27

Ren, Yanli, Jinhua Shang, Jinliang Li, et al. "The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma." Journal of Biological Chemistry 292, no. 43 (2017): 17939–49. http://dx.doi.org/10.1074/jbc.m116.773978.

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The long non-coding RNA (lncRNA) PCAT-1 resides in the chromosome 8q24 cancer-risk locus and acts as a vital oncogene during tumorigenesis and progression. However, how PCAT-1 is post-transcriptionally regulated, for example, by small ncRNAs, such as microRNAs (miRNAs) is largely unknown. Here, we report how miRNAs regulate PCAT-1 expression and also investigate the biological significance of this regulation in hepatocellular carcinoma (HCC). We found that miR-215, a P53-inducible miRNA, is a key regulator of PCAT-1 expression in HCC and identified an interaction between miR-215 and PCAT-1 in

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28

Benitez, Jose Carlos, Tania Diaz, Carme Ferrer, et al. "LincRNA-p21 as predictive response marker for preoperative chemoradiotherapy in rectal cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e15534-e15534. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15534.

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e15534 Background: Preoperative chemoradiotherapy (CRT) is a standard treatment for locally advanced rectal cancer (RC) patients (pts). Despite the benefits of CRT, its use in non-responder pts can be associated with increased toxicities and resection delay. The identification of CRT response biomarkers, such as long non-coding RNAs (lncRNA), could improve the management of these pts. LincRNA-p21 is a lncRNA involved in the p53 pathway and angiogenesis regulation that acts as prognostic marker in several tumors. We aim to study lincRNA-p21 expression in pretreatment samples from RC pts treated

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29

Салеева, Д. В., В. Ф. Михайлов, Л. В. Шуленина, et al. "Activities of regulatory RNAs that affect development of tumor cells in patients with laryngeal cancer." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 4() (November 21, 2018): 67–74. http://dx.doi.org/10.25557/0031-2991.2018.04.67-74.

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Цель. Определение прогностической значимости и роли экспрессии некодирующих РНК (длинные РНК и микроРНК), и белка кодирующих генов в патогенезе рака гортани. Методика. Исследован биопсийный материал и периферическая кровь 35 пациентов с диагнозом плоскоклеточный рак гортани (ПРГ) с классификацией от T1N0M0 до T4N1M0. Контролем служили образцы близлежащей гистологически неизмененной ткани гортани тех же больных. Для оценки экспрессии генов исследовали кровь 27 здоровых доноров. Содержание мРНК генов ( р53, CCND1, ORAOV1, hPTEN ), длинных некодирующих РНК (днРНК): NEAT1, MALAT1, ROR , а также зр

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Deng, Zhen, Jiaxing Hou, Hongbo Xu, et al. "The Prognostic Value of a lncRNA Risk Model Consists of 9 m6A Regulator-Related lncRNAs in Hepatocellular Carcinoma (HCC)." Evolutionary Bioinformatics 19 (January 2023): 117693432211420. http://dx.doi.org/10.1177/11769343221142013.

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Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Although the RNA modification N6-methyladenine (m6A) has been reported to be involved in HCC carcinogenesis, early diagnostic markers and promising personalized therapeutic targets are still lacking. In this study, we identified that 19 m6A regulators and 34 co-expressed lncRNAs were significantly upregulated in HCC samples; based on these factors, we established a prognostic signal of HCC associated with 9 lncRNAs and 19 m6A regulators using LASSO Cox regression analysis. Kaplan-Meier survival estimate revealed

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Xiang, SongTao, PeiLiang Zou, JingJing Wu та ін. "Crosstalk of NF-κB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1–Enzalutamide Combination Treatment". Cellular Physiology and Biochemistry 47, № 2 (2018): 759–73. http://dx.doi.org/10.1159/000490028.

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Background/Aims: Polyphyllin I (PPI), one of the steroidal saponins in Paris polyphylla, reportedly exhibits antitumor effects. However, the detailed mechanism underlying PPI, particularly in enhancing the effect of the androgen receptor inhibitor enzalutamide in controlling castration-resistant prostate cancer (CRPC) has not been explored. Methods: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively. Long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) expressi

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Hsieh, Pei-Fang, Cheng-Chia Yu, Pei-Ming Chu, and Pei-Ling Hsieh. "Long Non-Coding RNA MEG3 in Cellular Stemness." International Journal of Molecular Sciences 22, no. 10 (2021): 5348. http://dx.doi.org/10.3390/ijms22105348.

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Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This review focuses on the molecular mechanisms by which lncRNA MEG3 functions as a signal, scaffold, guide, and decoy for multi-lineage differentiation and even cancer progression. The role of MEG3 in various types of stem cells and cancer stem cells is discussed. Here, we provide an overview of the function

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Wang, Yaqi, Mengzhen Xue, Fangqi Xia, et al. "Long Non-Coding RNA GAS5 in Age-Related Diseases." Current Medicinal Chemistry 29, no. 16 (2022): 2863–77. http://dx.doi.org/10.2174/0929867328666211027123932.

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Abstract: Aging refers to a natural process and a universal phenomenon in all cells, tissues, organs, and the whole organism. Long non-coding RNAs (lncRNAs) are non-coding RNAs with a length of 200 nucleotides. LncRNA growth arrest-specific 5 (lncRNA GAS5) is often down-regulated in cancer. The accumulation of lncRNA GAS5 has been found to be able to inhibit cancer growth, invasion, and metastasis while enhancing the sensitivity of cells to chemotherapy drugs. LncRNA GAS5 can be a signaling protein, which is specifically transcribed under different triggering conditions. Subsequently, it is in

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Kloecker, G., C. Taylor, N. Vinayek, and D. Taylor. "Exosomal Long Non-Coding RNA (LNCRNA) in Lung Cancer." Annals of Oncology 23 (September 2012): ix76. http://dx.doi.org/10.1016/s0923-7534(20)32740-x.

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Xu, Wen, Bei Wang, Yuxuan Cai, et al. "ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis." Current Pharmaceutical Design 27, no. 23 (2021): 2722–27. http://dx.doi.org/10.2174/1381612827666210325105106.

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Background: Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways, such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers. Methods: Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms in cancer are summarized inductively. Results: ADAMTS9-AS2 aberrantly ex

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Chen, Yi-Cheng, Yu-Chi Chou, Yu-Tung Hsieh, et al. "Targeting Intra-Pulmonary P53-Dependent Long Non-Coding RNA Expression as a Therapeutic Intervention for Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage." International Journal of Molecular Sciences 22, no. 13 (2021): 6948. http://dx.doi.org/10.3390/ijms22136948.

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Diffuse alveolar hemorrhage (DAH) in systemic lupus erythematosus (SLE) is associated with significant mortality, requiring a thorough understanding of its complex mechanisms to develop novel therapeutics for disease control. Activated p53-dependent apoptosis with dysregulated long non-coding RNA (lncRNA) expression is involved in the SLE pathogenesis and correlated with clinical activity. We examined the expression of apoptosis-related p53-dependent lncRNA, including H19, HOTAIR and lincRNA-p21 in SLE-associated DAH patients. Increased lincRNA-p21 levels were detected in circulating mononucle

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Decmann, Abel, Pál Perge, Peter Istvan Turai, Attila Patócs, and Peter Igaz. "Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis." Cancers 12, no. 2 (2020): 461. http://dx.doi.org/10.3390/cancers12020461.

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Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive and there are no reliable blood-borne markers of adrenocortical malignancy, either. Several findings show the potential applicability of microRNAs as biomarkers of malignancy and prognosis, and there are some data on lncRNA as well. In this review, we present a synopsis on the potential relevance of non-

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Arun, Gayatri, Disha Aggarwal, and David L. Spector. "MALAT1 Long Non-Coding RNA: Functional Implications." Non-Coding RNA 6, no. 2 (2020): 22. http://dx.doi.org/10.3390/ncrna6020022.

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The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is one of the most well-studied lncRNAs. MALAT1 is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, Malat1 has been shown to be dispensable for normal development and viability

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Nath, Aritro, Paul Geeleher, and R. Stephanie Huang. "Long non-coding RNA transcriptome of uncharacterized samples can be accurately imputed using protein-coding genes." Briefings in Bioinformatics 21, no. 2 (2019): 637–48. http://dx.doi.org/10.1093/bib/bby129.

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Abstract Long non-coding RNAs (lncRNAs) play an important role in gene regulation and are increasingly being recognized as crucial mediators of disease pathogenesis. However, the vast majority of published transcriptome datasets lack high-quality lncRNA profiles compared to protein-coding genes (PCGs). Here we propose a framework to harnesses the correlative expression patterns between lncRNA and PCGs to impute unknown lncRNA profiles. The lncRNA expression imputation (LEXI) framework enables characterization of lncRNA transcriptome of samples lacking any lncRNA data using only their PCG profi

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Zhang, Xiao-Zhen, Hao Liu, and Su-Ren Chen. "Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations." Cancers 12, no. 5 (2020): 1245. http://dx.doi.org/10.3390/cancers12051245.

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Long non-coding RNA (lncRNA), which is a kind of noncoding RNA, is generally characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit many biological activities, including, but not limited to, cancer development. In this review, a search of the PubMed database was performed to identify relevant studies published in English. The term “lncRNA or long non-coding RNA” was combined with a range of search terms related to the core focus of the review: mechanism, structure, regulation, and cancer. The eligibility of the retrieved studies was mainly based on the abstract.

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Xu, Cheng Lin, Ben Sang, Guang Zhi Liu, et al. "SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms." Nucleic Acids Research 48, no. 6 (2020): 3089–102. http://dx.doi.org/10.1093/nar/gkaa063.

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Abstract Long non-coding RNAs (lncRNAs) have emerged as important biological tuners. Here, we reveal the role of an uncharacterized lncRNA we call SENEBLOC that is expressed by both normal and transformed cells under homeostatic conditions. SENEBLOC was shown to block the induction of cellular senescence through dual mechanisms that converge to repress the expression of p21. SENEBLOC facilitates the association of p53 with MDM2 by acting as a scaffold to promote p53 turnover and decrease p21 transactivation. Alternatively, SENEBLOC was shown to affect epigenetic silencing of the p21 gene promo

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Yang, Si-Jia, Jia-Lu Weng, Bin Wei, and Xue-Kui Du. "Long non-coding RNA DUXAP8 regulates the cell proliferation and invasion of non-small-cell lung cancer." Open Life Sciences 14, no. 1 (2019): 201–7. http://dx.doi.org/10.1515/biol-2019-0022.

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AbstractTo investigate how long non-coding RNAs DUXAP8 (LncRNA DUXAP8) influence the cell proliferation and invasion of non-small-cell lung cancer (NSCLC), we detected the expression levels of LncRNA DUXAP8 in lung cancer (LC) tissues, 4 LC-related cell lines (A549, SPC-A1, SK-MES-1 and NCI-H1299) and normal lung tissues via quantitative real-time PCR (qRT-PCR). Compared with normal lung tissue, LncRNA DUXAP8 was significantly up-regulated in NSCLC, especially in stage III / IV and diameter ≥ 3cm of lung cancer. Among 4 lung cancer cell lines, LncRNA DUXAP8 in A549 cells was the highest (P<

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Gumiela, Dorota. "The role of long non-coding RNA (lncRNA) in the development of ovarian cancer." Current Gynecologic Oncology 18, no. 2 (2020): e46-e56. http://dx.doi.org/10.15557/cgo.2020.0010.

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The aim of this study was to review research on the role of long non-coding RNA (lncRNA) in ovarian cancer. This article analyses studies on the effect of increased lncRNA expression on the size of ovarian cancer and the incidence of metastasis. The review covers a period from October 15, 2018 to August 22, 2020, and comprises 23 studies in which a total of 1,580 women with ovarian cancer participated, and an undetermined number of control groups where healthy tissue samples were collected. A review of the studies indicates that increased lncRNA expression is associated with elevated ovarian c

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Malouf, Gabriel, Jianping Zhang, Nizar M. Tannir, et al. "Charting DNA methylation of long non-coding RNA in clear-cell renal cell carcinoma." Journal of Clinical Oncology 33, no. 7_suppl (2015): 432. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.432.

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432 Background: Long non-coding RNAs (lncRNA) play a key role in regulating cell physiology through different mechanisms including the recruitment of histone-modifying enzymes. Recently, lncRNA classification of clear-cell renal cell carcinomas (cc-RCC) established four subtypes with different clinico-pathological features. However, the interplay between those lncRNA and DNA methylation patterns remains unknown. Methods: We performed a genomic analysis of GENCODE lncRNAs in cc-RCC using The Cancer Genome Atlas (TCGA) molecular RNAseq profiles of 471 primary tumors. Furthermore, we reannotated

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Liu, Xiaobing, Yaxing Hao, Wei Yu, et al. "Long Non-Coding RNA Emergence During Renal Cell Carcinoma Tumorigenesis." Cellular Physiology and Biochemistry 47, no. 2 (2018): 735–46. http://dx.doi.org/10.1159/000490026.

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Renal cell carcinoma (RCC) is the most common kidney cancer diagnosed across the globe and has steadily increased in incidence in recent decades. Techniques for diagnosing or treating RCC are limited, and confined mostly to later stages of the disease. Almost all RCC pathological types are resistant to chemotherapeutics and radiation therapy. To this effect, new markers for diagnosis and target therapy are urgently needed. Advanced genome sequencing technologies have revealed long non-coding RNAs (lncRNAs) as a novel marker, transcribed throughout the human genome. The emergence of lncRNAs is

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Sun, Yutong, and Li Ma. "New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis." Cancers 11, no. 2 (2019): 216. http://dx.doi.org/10.3390/cancers11020216.

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to regulate alternative pre-mRNA splicing and gene expression. However, Malat1 knockout mice develop and grow normally, and do not show alterations in alternative splicing. While MALAT1 was originally described as a prognostic marker of lung cancer metastasis, emerging evidence has linked this lncRNA to other cancers, such as breast cancer, prostate

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Ruan, Zhi, Hui Ma, Jing Li, Huiyong Liu, Haoruo Jia, and Feng Li. "The long non-coding RNA NEAT1 contributes to extracellular matrix degradation in degenerative human nucleus pulposus cells." Experimental Biology and Medicine 243, no. 7 (2018): 595–600. http://dx.doi.org/10.1177/1535370218760774.

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Intervertebral disc degeneration is a complex disease involving genetic and environmental factors and multiple cellular processes. The role and expression of the lncRNA NEAT1 were assessed in intervertebral disc degeneration. NEAT1 expression was assessed in degenerative and control nucleus pulposus using RT-PCR. Western blotting and RT-PCR were also used to investigate p53 and p21 levels in nucleus pulposus tissues. NEAT1 function in degenerative nucleus pulposus cells was assessed with gain- and loss-of-function experiments. ERK/MAPK signaling was also examined. NEAT1, p53, and p21 were dram

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Dehghani-Samani, Mina, Naiemeh Hassanzadeh, Hamidreza Kabiri, et al. "Correlations between Overexpression of SOX2OT Long Non-coding RNA and Susceptibility to Breast Cancer." Combinatorial Chemistry & High Throughput Screening 23, no. 9 (2020): 981–87. http://dx.doi.org/10.2174/1386207323666200514075042.

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Background and Objective: The SOX2OT lcnRNA has been recognized as a positive regulator in the transcription regulation of the SOX2 gene. Recent studies have approved the dysregulation of SOX2OT lncRNA expression patterns in some common cancer types, including esophageal, lung, and breast cancer. The objective of the present study was to investigate the correlation between overexpression of SOX2OT lcnRNA and susceptibility to breast cancer. Methods: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent breast tissue samples was performed by using qRT-PCR. To evaluat

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Wang, Lihua, Pengcheng Bu, Yiwei Ai, et al. "A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division." eLife 5 (April 14, 2016). http://dx.doi.org/10.7554/elife.14620.

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The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upst

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Naipauer, Julián, Martín E. García Solá, Daria Salyakina, et al. "A Non-Coding RNA Network Involved in KSHV Tumorigenesis." Frontiers in Oncology 11 (June 16, 2021). http://dx.doi.org/10.3389/fonc.2021.687629.

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Regulatory pathways involving non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNA), have gained great relevance due to their role in the control of gene expression modulation. Using RNA sequencing of KSHV Bac36 transfected mouse endothelial cells (mECK36) and tumors, we have analyzed the host and viral transcriptome to uncover the role lncRNA-miRNA-mRNA driven networks in KSHV tumorigenesis. The integration of the differentially expressed ncRNAs, with an exhaustive computational analysis of their experimentally supported targets, led us to dissect complex netw

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