Дисертації з теми "Cancer Clusters"
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Rattican, Debra. "Symptom Clusters in Lung Cancer Patients." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/352.
Повний текст джерелаChau, Hau-yan, and 周厚仁. "Symptom clusters among Chinese women with breast cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48422563.
Повний текст джерелаpublished_or_final_version
Public Health
Master
Master of Public Health
Maguire, Roma. "Where is the person in symptom cluster research? : the experience of symptom clusters in patients with advanced lung cancer." Thesis, University of Stirling, 2011. http://hdl.handle.net/1893/3423.
Повний текст джерелаKim, Jung-Eun Esther. "Multiple symptoms and symptom clusters in patients with cancer." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324589.
Повний текст джерелаStults, Dawn Michelle. "Human ribosomal RNA gene clusters are recombinational hotspots in cancer." Lexington, Ky. : [University of Kentucky Libraries], 2009. http://hdl.handle.net/10225/1122.
Повний текст джерелаTitle from document title page (viewed on May 6, 2009). Document formatted into pages; contains: v, 27 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 25-26).
Morrison, Eleshia JP. "Examining the Presence of Symptom Clusters in Patients with Advanced Cancer." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259769198.
Повний текст джерелаDong, Skye Tian. "Symptom Clusters in Patients with Advanced Cancer: A mixed methods investigation." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/14987.
Повний текст джерелаSkerman, Helen Mary. "Alternative analytical methods for the identification of cancer-related symptom clusters." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/34503/1/Helen_Skerman_Thesis.pdf.
Повний текст джерелаCrane, Tracy E., and Tracy E. Crane. "Symptom Clusters and Trajectories of Depression and Anxiety in Latina Breast Cancer Survivors." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621858.
Повний текст джерелаStults, Dawn Michelle. "STRUCTURAL INSTABILITY OF HUMAN RIBOSOMAL RNA GENE CLUSTERS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/68.
Повний текст джерелаLe, Boiteux Elisa. "Altération du contrôle de H3K27me3 et dérégulation transcriptionnnelle dans les gliomes : études des clusters HOX." Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAS027.
Повний текст джерелаEpigenetic alterations are a well-known signature of cancer cells. However, the causes of these defects, as well as their consequence on gene expression, remain elusive. My thesis project specifically lies in this thematic, and focuses on the causes and consequences of epigenetic alterations in gliomas. These brain tumors can be divided into two subsets, based on IDH mutation status, that are characterized by different methylation profiles. Interestingly, the mutation of IDH is also associated with a better prognosis. Our strategy, based on exhaustive molecular analyses, relies on the study of 70 glioma samples, classified according to their IDH status, and of six glioblastoma stem cell (GSC) lines.We found that most transcriptional alterations in tumor samples were DNA methylation-independent. Instead, altered histone H3 trimethylation at lysine 27 (H3K27me3) was the predominant molecular defect at deregulated genes. Our results also suggest that the presence of a bivalent chromatin signature at CpG island promoters in stem cells predisposes not only to hypermethylation, as widely documented, but more generally to all types of transcriptional alterations in transformed cells. In addition, the gene expression strength in healthy brain cells influences the choice between DNA methylation- and H3K27me3-associated silencing in glioma. Highly expressed genes were more likely to be repressed by H3K27me3 than by DNA methylation. Our findings support a model in which altered H3K27me3 dynamics, more specifically defects in the interplay between Polycomb protein complexes and the brain-specific transcriptional machinery, is the main cause of transcriptional alteration in glioma cells. Also, our study revealed that homeodomain genes, and in particular HOX genes, are characterized by an atypical defect in aggressive gliomas (IDHwt), associating a gain of expression with an aberrant gain of methylation. We determined that this alteration affect all the four HOX clusters, and that the reactivation of these genes is likely a consequence of the aberrant loss of H3K27me3 that specifically affect these clusters. This study allows to propose a model whereby global DNA hypomethylation triggers ectopic expression of numerous genes through a cascade of events, in which HOX gene alteration would have a central role.The observation that H3K27me3 is deregulated in gliomas, and particularly on HOX genes, also lead us to investigate for the role of non-coding RNA in these mechanisms. We have identified HOXA-AS2, a yet poorly characterized long non-coding RNA located at HOXA locus, that is specifically and significantly overexpressed in IDHwt gliomas. The inhibition of HOXA-AS2 in well-characterized CSG lines suggests that this transcript play a central role in the biology of these cells. Thus, it would contribute to the aggressiveness of CSG by inhibiting inflammatory pathways and promoting cell proliferation. Altogether, these works revisit the relationship between epigenetic alterations and aberrant transcription, and present the control of H3K27me3 as the main cause of transcriptionnel defects in cancer
Fukuyama, Keita. "Gene expression profiles of liver cancer cell lines reveal two hepatocyte-like and fibroblast-like clusters." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265181.
Повний текст джерелаHagihara, Takeshi. "Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer." Kyoto University, 2020. http://hdl.handle.net/2433/253210.
Повний текст джерелаJoseph, Anny-Claude. "Assessing the Impact of Incorporating Residential Histories into the Spatial Analysis of Cancer Risk." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5949.
Повний текст джерелаIvermark, Katarina. "Attacking cancer biomarker clusters from all sides : - bispecific, bivalent and polyspecific affinity proteins towards HER family receptors." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-292941.
Повний текст джерелаWeston, William Christopher. "A SPATIAL ANALYSIS OF INVASIVE BREAST CANCER CLUSTERS IN ASSOCIATION WITH ENVIRONMENTAL RISK FACTORS: ILLINOIS 1996 TO 2000." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/896.
Повний текст джерелаJurvilliers, Xavier. "Nanoparticules fonctionnalisées pour une vectorisation médicale active." Vandoeuvre-les-Nancy, INPL, 2003. http://www.theses.fr/2003INPL085N.
Повний текст джерелаThe first part of this work describes the preparation of new organic/inorganic naanohybrids which are intended to be used for the detection and the selective destruction of cancer cells. We describe the synthetic methodology for covalent attachment of folie acid (organic moiety) to gold nanoparticles (inorganic moiety) sized between 5 and 20 mn. Aminothiols spacers were used for the linking of folic acid with gold particles. The second part describes the preparation of size-controlled gold clusters by reduction of gold (+3) bromide with an alkoxide activated hydride. We have demonstrated that an appropriate choice of hydride (NaH or LiH) end / or of the solvent used for the reduction allows either the preparation of 2 nm sized spherical gold clusters or gold nanoprisms (nanowires and polygonal shapes)
Abduljawad, Suzan Fouad. "Fatigue-related Symptom Clusters and their Relationship with Depression, and Functional Status in Older Adults Hospice Patients with Cancer." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7659.
Повний текст джерелаGuajardo, Olga A. "A critical assessment of geographic clusters of breast and lung cancer incidences among residents living near the Tittabawassee River, Michigan /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1594501451&sid=11&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерелаBonaldi, Christophe. "Analyse de clusters sur le temps : application en carcinologie et en épidémiologie." Montpellier 1, 2003. http://www.theses.fr/2003MON1T017.
Повний текст джерелаDi, Puma Salvatore Davide. "Progettazione sintesi e valutazione biologica dei lipopeptidi contenenti clusters multimerici dell'epitopo immunodominante pdtrp per l'immunoterapia attiva del cancro." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1174.
Повний текст джерелаNewman, Christopher Miles. "Randomised controlled trial to evaluate a direct referral service for investigation of patients with low risk sympton clusters suggestive of colorectal cancer, as against usual care." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431949.
Повний текст джерелаSundqvist, Martina. "Stability and selection of the number of groups in unsupervised clustering : application to the classification of triple negative breast cancers." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASM026.
Повний текст джерелаIn this thesis, I treat the topic of classifying Triple Negative Breast Cancer (TNBC) tumors from a statistical point of view. After proposing a classification of TNBC based on proteins, I mainly focus on the use of cluster stability for selecting the number of groups in unsupervised clustering. Indeed, this is the method generally employed when classifying TNBC. The aim of this method is to obtain a classification that is robust, that is, easily replicable on similar data. This is measured by its sensibility to small changes, such as subsamplig of the dataset.Despite the popularity of this method, little is still known about how or when it works. For this reason, I propose two important methodological contributions, increasing the usability and interpretability of this method: (1) an R-package, clustRstab, that easily enables to estimate the stability of a clustering in different parameter settings. This package is accompanied by a simulation and an application study investigating when and how this method works. (2) A Modified version of the Adjusted Rand Index (ARI), a popular score for cluster comparisons which is a crucial step for estimating the stability of a clustering. I correct this score by basing it on a multinomial distribution hypothesis which enables it to take into account dependence between clusterings and conduct statistical inference. This Modified ARI (M ARI) is implemented in the R package texttt{aricode}.These two methods are then applied to a large cohort of TNBC tumors and the results are discussed in relation to earlier classification results of TNBC
Hassan, Sara. "Epithelial-mesenchymal plasticity in circulating tumour cells from patients with metastatic cancers and PDX models." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228621/8/Sara_Hassan_Thesis.pdf.
Повний текст джерелаGraffeo, Nathalie. "Méthodes d'analyse de la survie nette : utilisation des tables de mortalité, test de comparaison et détection d'agrégats spatiaux." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5067/document.
Повний текст джерелаIn cancer research, net survival is a key indicator of health care efficiency. This theoretical concept is the survival that would be observed in an hypothetical world where the disease under study would be the only possible cause of death. In population-based studies, where cause of death is unknown, net survival allows to compare net cancer survival between different groups by removing the effect of death from causes other than cancer. In this work, after presenting the concept and the estimation methods of net survival, we focus on three complementary issues. The first one is about the life tables used in the estimates of net survival. In France, these tables are stratified by age, sex, year and département. Other prognostic factors impact on mortality. So it would be interesting to use life tables stratified by some of these factors. We study the impact of the lack of stratification in life tables on the estimates of the effects of prognostic factors on excess mortality by simulations and real data studies. In 2012, the Pohar-Perme estimator was proposed. It is a consistent non parametric estimator of net survival. The second issue involves the building of a log-rank type test to compare distributions of net survival (estimated by the Pohar-Perme estimator) between several groups. Our third issue is to propose a method providing potential spatial clusters which could contain patients with similar net cancer survival rates. We adapt a clustering method using the test we have built as a splitting criterion. This work proposes new developments and new tools to study and improve the quality of care for cancer patients. These methods are suitable to other chronic diseases
Guo, Ling. ""Clustering categorical response" application to lung cancer problems in living scales." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-04202008-163156/.
Повний текст джерелаTitle from file title page. Jiawei Liu, Yu-sheng Hsu, committee co-chairs; Jeff Qin, committee member. Electronic text (82 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Aug. 20, 2008. Includes bibliographical references (p. 65-66).
Weber, Erich. "Biochemical, immunological and functional characterization of the human small cell lung cancer related cell surface antigens cluster-1 (N-CAM CD56), cluster-4 (CD24) and cluster-5/5A /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10735.
Повний текст джерелаGu, Jin. "Statistical partition problem for exponential populations and statistical surveillance of cancers in Louisiana." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1921.
Повний текст джерелаSerier, Asma. "Étude de l’activité anti-tumorale des entérotoxines staphylococciques codées par l’enterotoxin gene cluster." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10171.
Повний текст джерелаThe use of classical superantigens (e.g. SEA, SEB and SEC) for treatment of cancer has resulted in a low response rates due to serious toxicity in humans. However, in a recent clinical study, remarkable results in treating lung cancer were obtained using superantigens encoded by the enterotoxin gene cluster (egc) without causing any significant toxicity. The current study was performed to investigate how egc superantigens (i.e. SEG, SEI, SElM, SElN and SElO) have tumoricidal activity with low toxicity. Indeed, we first demonstrated that tumoricidal activity of egc-SEs is mediated by immune cell activation, in particular, by secretion of soluble mediators such as nitric oxide and TNF-α. Thus, the proteomic analysis of the PBMC supernatants, showed that SEs-egc enhance the expression of pro-inflammatory cytokines, chimokines and many other biomarkers. Interestingly, levels were significantly higher in supernatants of SEA-stimulated PBMC than those with egc superantigens suggesting that staphylococcal superantigens differs in their inflammatory proprerties. Our results suggest that the relative lower pro-inflammatory activity of egc toxins may explain the low toxicity of these toxins observed during the clinical trial. Finally, we showed that SElO have a direct cytostatic activity against tumor cells. These findings suggest that egc-SEs seems to be good candidates for the development of new drugs in cancer therapy
Al-Hinnawi, Abdel-Razzak. "Computer aided detection of clustered micro-calcifications in the digitised mammogram." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301076.
Повний текст джерелаMeddis, Alessandra. "Inference and validation of prognostic marker for correlated survival data with application to cancer." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASR005.
Повний текст джерелаClustered data often arises in medical research. These are characterized by correlations between observations belonging to the same cluster. Here, we discuss some extension to clustered data in different contexts: evaluating the performance of a candidate biomarker, and assessing the treatment effect in an individual patient data (IPD) meta-analysis with competing risks. The former was motivated by the IMENEO study, an IPD meta-analysis where the prognostic validity of the Circulating Tumor Cells (CTCs) was of interest. Our objective was to determine how well CTCs discriminates patients that died from the one that did not within the t-years, comparing individuals with same tumor stage. Although the covariate-specific time dependent ROC curve has been widely used for biomarker's discrimination, there is no methodology that can handle clusteres censored data. We proposed an estimator for the covariate-specific time dependent ROC curves and area under the ROC curve when clustered failure times are detected. We considered a shared frailty model for modeling the effect of the covariates and the biomarker on the outcome in order to account for the cluster effect. A simulation study was conducted and it showed negligible bias for the proposed estimator and a nonparametric one based on inverse probability censoring weighting, while a semiparametric estimator, ignoring the clustering, is markedly biased.We further considered an IPD meta-analysis with competing risks to assess the benefit of the addition of chemotherapy to radiotherapy on each competing endpoint for patients with nasopharyngeal carcinoma. Recommendations for the analysis of competing risks in the context of randomized clinical trials are well established. Surprisingly, no formal guidelines have been yet proposed to conduct an IPD meta-analysis with competing risk endpoints. To fill this gap, this work detailed: how to handle the heterogeneity between trials via a stratified regression model for competing risks and it highlights that the usual metrics of inconsistency to assess heterogeneity can readily be employed. The typical issues that arise with meta-analyses and the advantages due to the availability of patient-level characteristics were underlined. We proposed a landmark approach for the cumulative incidence function to investigate the impact of follow up on the treatment effect.The assumption of non informative cluster size was made in both the analyses. The cluster size is said to be informative when the outcome depends on the size of the cluster conditional on a set of covariates. Intuitively, a meta-analysis would meet this assumption. However, non informative cluster size is commonly assumed even though it may be not true in some situations and it leads to incorrect results. Informative cluster size (ICS) is a challenging problem and its presence has an impact on the choice of the correct methodology. We discussed more in details interpretation of results and which quantities can be estimated under which conditions. We proposed a test for ICS with censored clustered data. To our knowledge, this is the first test on the context of survival analysis. A simulation study was conducted to assess the power of the test and some illustrative examples were provided.The implementation of each of these developments are available at https://github.com/AMeddis
Sakr, Lama. "Phenotypic heterogeneity of potentially curable non-small cell lung cancer: cohort study with cluster analysis." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116984.
Повний текст джерелаContexte: La classification TNM dans le cancer bronchique non à petites cellules (CBNPC) est actuellement le meilleur outil pronostique. Cependant, une hétérogénéité significative quant à la présentation et l'évolution clinique de la maladie est observée chez les patients dont le stade est potentiellement curable. Un système de classification plus élaboré, incorporant de façon simultanée plusieurs aspects de la maladie, permettrait d'identifier certains profils distincts du CBNPC, et ainsi offrir une meilleure prédiction de l'évolution clinique. Objectifs : 1) Classifier les patients avec CPNPC en phénotypes distincts, à l'aide de l'analyse de partitionnement de données (APD)- une technique statistique multi-variée. 2) Valider la pertinence clinique de ces phénotypes en comparant l'évolution clinique de chacun. Méthodes : Une revue de données prospectives sur les patients avec CBNPC stades I- III, diagnostiqué entre Janvier 2004 et Octobre 2010, a été effectuée. L'analyse des correspondances multiples a été appliquée sur un ensemble de variables de base, et suivie d'une APD hiérarchique utilisant la méthode de Ward. Des analyses de survie ont été effectuées à l'aide de la technique Kaplan-Meier. Les paramètres de survie globale et de survie sans progression ont été comparés entre les différents phénotypes, en ayant recours au modèle à risques proportionnels de Cox. Résultats: La cohorte complète (n= 367), ainsi qu'une sous-cohorte chirurgicale (n=169), ont été analysés. Dans la cohorte complète, un modèle de partitionnement de données à 3 ou 4 groupes est illustré. Les phénotypes se distinguaient par la distribution des sexes, tabagisme, stade de la maladie, degré de différentiation- et parfois le sous-type histologique- activité métabolique de la tumeur, et l'expression du facteur de transcription thyroïdienne en analyse immunohistochimique. La sous-cohorte chirurgicale était également représentée par un modèle de partition en 3 ou 4 groupes, se démarquant par les facteurs décrits ci-haut, en plus du statut de l'EGFR et l'invasion microscopique vasculaire et de la plèvre viscérale. Les paramètres de survie globale et sans progression différaient de façon significative entre les phénotypes établis, et ce, dans les deux cohortes. L'ajustement pour l'âge n'a pas modifié les résultats de façon notable. Conclusion: L'APD permet l'identification de phénotypes distincts de CBNPC, ayant des différences importantes quant à la présentation et l'évolution clinique de la maladie.
Nguyen, Ly Thuy. "A psycho-educational intervention for symptom cluster management among cancer patients undergoing treatment in Vietnam." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/116352/1/Ly%20Thuy_Nguyen_Thesis.pdf.
Повний текст джерелаLau, Sze-hang Billy, and 劉思行. "Identification and characterization of key genes involved in the development and progression of hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39346924.
Повний текст джерелаBravi, F. "DIETARY PATTERNS AND ESOPHAGEAL CANCER: A POSTERIORI DIETARY PATTERNS IDENTIFIED THROUGH FACTOR ANALYSIS AND CLUSTER ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/215074.
Повний текст джерелаGlackin, A. J. "The synergy of gemcitabine with clusterin antisense oligonucleotides in the treatment of bladder cancer." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426981.
Повний текст джерелаSo, Kwok-Wei. "The symptom cluster of fatigue, pain and psychological distress and its impact on the quality of life in Chinese patients with breast cancer undergoing cancer treatment /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
Знайти повний текст джерелаTypescript. Includes bibliographical references (leaves 168-181). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
Sakiragaoglu, Onur. "Strategies for Knockdown of Gene Products That Promote Cancer Growth." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/366861.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
Full Text
Wells, Kristen. "The Development and Use of a Geographic Information System for Evaluating the Association between Pesticide Exposure and Prostate Cancer." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2243.
Повний текст джерелаKulasinghe, Arutha Jeevana. "Circulating tumour cells in head and neck cancers." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110534/1/Arutha%20Jeevana_Kulasinghe_Thesis.pdf.
Повний текст джерелаMaloney, Stephanie Louise. "An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/612/.
Повний текст джерелаFuziwara, Cesar Seigi. "O cluster de microRNAs miR-17-92 e seus alvos na oncogênese tiroidiana: influência de BRAFT1799A e de iodo." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-19112014-162309/.
Повний текст джерелаIodine excess blocks cell proliferation and inhibits hormone synthesis, while delays oncogenic effects of RET/PTC3 activation in thyroid follicular cells. BRAF mutation (T1799A) is the most prevalent genetic alteration in thyroid cancer, and transgenic mice model for BRAF develops thyroid cancer that progress to aggressive histotypes. High levels of microRNAs (miRNAs) of miR-17-92 cluster are associated to aggressive thyroid cancer and modulate translation of target mRNAs in oncogenic signaling pathways. In this study, we evaluated the influence of high dose iodine in miRNAs under BRAF oncogene activation, and its effects in thyroid follicular cell biology. BRAF induction induces high expression of miR-17-92 while high dose iodine blocks this effect in thyroid follicular cells. miR-19 inhibits Smad4 translation and impairs TGFb signaling transduction, effect reverted by iodine. Iodine modulates miR-17-92 expression by interfering in BRAF-induced Notch signaling activation. These results indicate that iodine protects thyroid follicular cell during BRAF induction, reverting oncogenic miR-17-92 activation and restoring protein levels of Smad4 by Notch signaling modulation.
Ronquist, Göran. "Some Characteristics of Human Prostasomes and Their Relationship to Prostate Cancer." Doctoral thesis, Uppsala universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100799.
Повний текст джерелаKuang, Da. "Nonnegative matrix factorization for clustering." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/52299.
Повний текст джерелаBulteau, François. "Ciblage in vivo des tumeurs via l'antigène Tn : Développement d'un cluster de Macrophage Galactose Lectine Human Macrophage Galactose-Type Lectin (MGL) Recognizes the Outer Core of Escherichia coli Lipooligosaccharide." Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALV048.
Повний текст джерелаAll cells, whether prokaryotic or eukaryotic, have a rich and diversified external glycosylation layer, forming the immediate dominant face in relation to their environment. They result from complex enzymatic processes linking sugars to each other and to proteins or lipids. Variations of the "glycome" can appear in certain pathologies. Cancers are the most frequent pathologies with abnormalities in these glycosylations. These alterations are almost systematic on the surface of cancer cells. Among them, the Thomsen-new antigen (Tn), an N-acetylgalactosamine (GalNAc) on a serine or threonine, is strongly expressed in 90% of mammary carcinomas as well as in cancers of the bladder, cervix, ovary, colon, stomach and prostate. The ubiquitous presence of the Tn antigen in many cancers, combined with its absence in healthy cells, makes it a target of choice for targeted therapy or synthetic anti-tumor vaccines. No antibody targeting the Tn antigen is currently available because of the difficulty in developing an antibody with such specificity. Thus, we were interested in an alternative targeting strategy, based on the use of a molecule capable of recognizing the Tn antigen. C-Type lectins are a family of proteins capable of specifically and reversibly binding to certain carbohydrates in the presence of calcium. Macrophage galactose lectin (MGL) is a C-type lectin with a high affinity for GalNac and its derivatives such as the Tn antigen. This work consisted, initially, in the use of a soluble recombinant form of MGL to validate the potential of this tool for the targeting of cancer cells. The different experiments, in vitro and in vivo, involving MGL, demonstrated the latter's ability to specifically target human tumors via the Tn antigen. The extracellular portion of MGL is therefore a very good vector candidate for the diagnosis and imaging of human tumors and potentially for drug delivery. In a second step, various strategies for the development of a bifunctional tool exploiting this lectin were explored. The goal was to create a peptide platform that could be functionalized on one hand with several lectin domains, in order to control recognition affinity, and on the other hand with functional groups that could be variable according to the application (diagnostic, therapeutic, ...). The different coupling strategies employed allowed us to attach several lectin CRDs to a peptide support, while preserving the three-dimensional and functional state of the proteins. The characterizations carried out show a significant increase in affinity directly related to the number of lectins added to the platform. This work paves the way to new customizable sugar-targeting systems
Gray, Michelle Elizabeth. "Towards Understanding the Cell Adhesion Mediated by Non-clustered Non-classical Protocadherins." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1605887233542288.
Повний текст джерелаGray, Michelle Elizabeth. "Towards Understanding the Cell Adhesion Mediated by Non-clustered Non-classical Protocadherins." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1605887233542288.
Повний текст джерелаKim, Doo Young. "Statistical Modeling of Carbon Dioxide and Cluster Analysis of Time Dependent Information: Lag Target Time Series Clustering, Multi-Factor Time Series Clustering, and Multi-Level Time Series Clustering." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6277.
Повний текст джерелаLindvall, Jenny. "Green and red fluorescent protein tagging of endogenous proteins in glioblastoma using the CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 system." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314151.
Повний текст джерелаMaster Thesis in Applied Biotechnology
Valdeolivas, Urbelz Alberto. "Approaches to explore multiplex biological networks and application to study premature aging diseases." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0106.
Повний текст джерелаGenes and proteins do not act isolated in cells but rather interact to perform their functions in signaling pathways, molecular complexes, or, more generally, biological processes. These interactions can be represented as large networks in which nodes are genes or proteins and edges represent their interactions. Various graph-theory based approaches have been developed to extract the functional knowledge contained in biological networks. Nevertheless, these methods have been mainly applied to individual networks, ignoring the diversity of biological interactions. We state here that these different types of interactions can be represented as multiplex networks, i.e. collections of networks sharing the same nodes, leading to a more accurate description of biological systems. This thesis focuses on the extension from individual to multiplex networks of some of the state-of-the-art guilt-by-association methods in computational biology, and on their application to the study of human diseases. On the application side, we concentrate on premature aging diseases, a group of rare genetic disorders that resemble some aspects of physiological aging at an early age. In this framework, we applied our algorithms to detect the modules associated to more than 70 disorders annotated with at least one premature aging related phenotype. The results revealed the landscape of perturbed molecular processes in premature aging diseases, which can be paralleled with the hallmarks of physiological aging to help identifying common and specific features