Дисертації з теми "Calvaria de rat"
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Stronski, Stefan A. Bettschen-Camin Liana. "Bisphosphonates inhibit 1,25-Dihydroxyvitamin D₃ induced osteocalcin synthesis in the rat in vivo and in the rat calvaria in vitro /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаBurim, Rafael Augusto. "Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-02092013-180120/.
Повний текст джерелаBone critical defect reconstruction is an important target in current oral surgery research. Contemporary research has been searching for osteogenesis optimization to minimize the necessity of using autogenous bone grafts procedures. Animal models have been the widespread methodology to evaluate the effect of different new substances and biomaterials in bone healing. The aim of this study was to assess the influence of systemic daily flavonoid, icariin, in the repair of calvaria critical size defects induced in Wistar rats. A round critical size defect was performed centrally in 40 rats calvaria using an 8mm trephine under sterile saline solution irrigation. After surgery, half the animals, randomly, received by gavage daily doses of 125mg/Kg-icariin (Test Group) till the euthanasia. The other half (Control Group) received the same volume of saline solution. Five animals of each group were euthanized after 7, 14, 21 and 42 days postoperatively. The rats calvaria were removed, fixed in 10% formalin for 48 hours. Calvarias were X-rayed and after decalcification they underwent histological examination with hematoxylin eosin stain under a light microscope. Defects were analyzed considering area diminishing in X-ray image, bone healing characteristics and osteogenesis in the defect region. Results showed that bone defect area in Test Group was significant smaller in all observational periods. Histological evaluation showed an increased expression in bone trabeculae neoformation in Test Group (p=0,02). Histomorphometry demonstrated significant osteogenesis in Test Group at 7 days (p=0,021), 14 days (p=0,014), 21 days (p=0,021) and 42 days (p=0,009). It was concluded that systemic icariin induced a more expressive bone healing in critical size defects in rats.
Molteni, Alexandra. "Interactions entre proteoglycannes sulfates et facteur de croissance fibroblastique-2 dans la chondro-osteogenese du condyle mandibulaire et l'osteogenese de la calotte cranienne de rat." Paris 5, 1998. http://www.theses.fr/1998PA05M106.
Повний текст джерелаAnagnostou, Fani. "Caracterisation de l'activite phosphohydrolase de l'ecto-phosphatase alcaline et son role dans la mineralisation dans les cellules de calvaria de rat foetal en culture." Paris 7, 1996. http://www.theses.fr/1996PA07GA02.
Повний текст джерелаNAAMAN, BOU-ABBOUD NADA. "Influence des biomateriaux alloplastiques, sur la reparation osseuse : etudes in vivo des potentiels osteoconducteurs et osteoinducteurs." Paris 7, 1997. http://www.theses.fr/1997PA07GA02.
Повний текст джерелаD'Aoust, Paul R. "The use of bisphosphonates to promote healing of rat calvarial wounds." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0027/MQ40754.pdf.
Повний текст джерелаMauro, Frank Armand. "Assessment of biodegradable calcium polyphosphate for bone substitute applications in the healing of the rat calvarium." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0004/MQ45973.pdf.
Повний текст джерелаRaman, Harini. "AN ORGANIC BOVINE HYDROXYAPATITE-PLGA COMPOSITES FOR BONE TISSUE ENGINEERING." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_theses/201.
Повний текст джерелаSilva, Claudia Jordão. "Efeito de eletroestimulação sobre o processo de reparo de cavidade ossea cirurgica, com ou sem enxerto osseo. Estudo histologico em calvaria de coelho." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289431.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O propósito deste trabalho foi avaliar histologicamente o processo de reparo de defeitos ósseos, criados cirurgicamente em calvária de coelho, com ou sem enxerto ósseo e submetidos ou não a eletroestimulação. Foram utilizados 18 coelhos, sendo que cada um deles recebeu duas osteotomias na calvária. Na osteotomia do osso parietal direito o fragmento removido foi imediatamente reposicionado, sendo que no parietal esquerdo o fragmento foi desprezado. Os animais dos grupos tratados receberam a eletroestimulação por uma hora, durante 21 dias. Já os animais do grupo controle foram submetidos as mesmas condições de stress, porém com o aparelho desligado. Os períodos de sacrifício foram as quatro, oito e quinze semanas, compreendendo seis animais sacrificados em cada período. A análise dos espécimes sob a microscopia óptica revelou neoformação óssea em todos os animais. Nos animais com enxerto ósseo houve uma reparação mais acentuada quando comparados com o grupo sem enxerto. A eletroestimulação parece ter alterado o processo de reparo ósseo de maneira discreta
Abstract: The purpose of this research was to histologicalIy evaluate the healing process in bone defects surgically created in calvaria of rabbits, with or without bone grafts under the action of eletrotherapy or not. It were utilized 18 rabbits with 2 perfurations in each calvaria. In the right parietal bone perforation the fragment removed was immediately grafted in its place. lu the left parietal bone the fragment was thrown away. The animais in the treated group received 1 hour of eletrotherapy dayly, during 21 days. The animals in the control group were submitted to the same stress conditions, but the stimulator was turned off. The sacrifice periods were 4, 7 and 15 weeks, with 6 sacrificed animais in each group. The analysis of the specimens under optical microscopy revealed bone formation in all animals. In the animals with the bone grafted there was a more noticeable healing when compared to the animais in the control group. With regard the electrotherapy it seems to affect the bone healing mildly
Mestrado
Cirurgia e Traumatologia Buco-Maxilo-Faciais
Mestre em Clínica Odontológica
Calvagna, Isabella [Verfasser], and Thomas [Akademischer Betreuer] Eckert. "Raising the quality of education in Europe by reducing the rate of early school leaving through international cooperation / Isabella Calvagna. Betreuer: Thomas Eckert." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1110749120/34.
Повний текст джерелаAmaral, Mauricio Bordini do. "Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-23052013-091250/.
Повний текст джерелаBiodegradable bone grafts have been widely employed on bone regeneration. The purpose of this study was to evaluate the osteoconductive potential of hydroxyapatite, mineralized bovine tendon and Bio-Oss/Geistlich in a rat critical-size calvaria defect model through non-destructive three-dimensional (3D) micro-tomographic (\'mü\'CT) imaging and histological evaluation. Two experimental biomaterials were developed: synthetic hydroxyapatite (particles size < 0,2 mm) and mineralized bovine tendon. Bio-Oss/Geistlich was employed as a control group. A critical size defect (8 mm) was created in the skull of Wistar rats (weight 200 - 300 g) and treated with the biomaterials and one group was left untreated in the control group (n = 5). After 30 days, the animals were killed and the calvaria removed for \'mü\'CT and histological analysis. No adverse reactions were noted. No bone repair was observed in untreated surgical defects. The results of micro-CT showed that BioOss showed higher volume, density and percentage of bone tissue than the other groups. In the images reconstructed in 3-D was noted in the group Bio-Oss the lowest rates of resorption, staying in larger quantities within thirty days of the defect. In the group of synthetic hydroxyapatite noticed an intense resorption of the material and a slight bone formation at the margins of the defect, leaving him with an irregular contour. The bovine tendon mineralized group presented discreet bone formation and the material was completely resorbed. In the evaluation of the presence of the material, blood vessels and osteoblastic cells within the defect obtained by histological analysis, the groups Bio-Oss and synthetic hydroxyapatite showed similar results and larger than the mineralized bovine tendon. We verified by histological analysis that the synthetic hydroxyapatite is present within the defect displaying osteoconductive properties similar to trademark BioOss. Already the mineralized bovine tendon, again, did not have good osteoconduction and is contraindicated in maintaining the bone. When comparing the two methods observed that the micro-CT has low specificity, ie, was not able to distinguish the bone tissue to Bio-Oss and high sensitivity, as quantified in a very accurate values with high resolution. Already histological analysis can accurately distinguish materials and tissues, but can not quantify them easily and accurately. Therefore, we conclude that the synthetic hydroxyapatite has great potential to be used to fill bone defects, unlike mineralized bovine tendon. When comparing the methods, we found that still are complementary and new enhancements must be made in micro-CT technique to improve their ability to distinguish different materials.
Strong, Ernest L. "Increasing knowledge about biblical faith in a local congregation /." Free full text is available to ORU patrons only; click to view, 2008. http://proquest.umi.com/pqdweb?did=1790275471&sid=1&Fmt=2&clientId=456&RQT=309&VName=PQD.
Повний текст джерелаCalderoni, Davi Reis 1982. "Avaliação do uso de placas sinterizadas de titânio com e sem recobrimento de beta-fosfato tricálcico no reparo de falhas ósseas em calvária de ratos = Evaluation of sintered titanium scaffolds with and without beta-tricalcium phosphate coating for calvarial defects repair in rats." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312994.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Introdução: A reparação de um defeito craniano é um procedimento desafiador, que requer não somente o preenchimento da falha óssea mas também estabilidade a longo prazo do material empregado e restabelecimento do contorno e simetria. Diversos tipos de materiais com diferentes características bem como diferentes métodos de produção dos implantes vêm sendo testados, sem que ainda haja um substituto ósseo considerado ideal. No presente estudo foram investigadas as propriedades de osteointegração de implantes da liga Ti6Al4V construídos por prototipagem com poros tridimensionalmente conectados considerando a influência do recobrimento dos mesmos com uma camada delgada de ?-fosfato tricálcico nestas propriedades. Método: Trinta ratos foram submetidos à criação de defeitos ósseos bilaterais na calvária, que foram preenchidos com implantes, recobertos ou não com ?-fosfato tricálcico, de modo aleatório. Os animais foram distribuídos em grupos e sacrificados 15, 45 e 90 dias após o procedimento. A integração dos implantes foi inicialmente avaliada por ensaio de compressão. A interface osso-implante foi analisada por meio de microscopia eletrônica de varredura. Resultados: A força máxima para produzir o deslocamento inicial dos implantes foi aumentando durante o período estudado, alcançando valores da ordem de 100N para ambos os tipos de implante. Foi observada integração entre o osso e a superfície dos implantes, com crescimento ósseo progressivo no interior dos poros. Não foram observadas diferenças significativas entre implantes recobertos e não recobertos por ?-fosfato tricálcico. Conclusão: Foi alcançada uma adequada osteointegração nas reconstruções cranianas utilizando implantes prototipados da liga Ti6Al4V com as características de porosidade e superfície descritas, sem influência do recobrimento cerâmico adotado. Os resultados sugerem que as características de construção utilizadas podem ser incorporadas aos implantes para reconstrução craniana para melhorar os resultados cirúrgicos
Abstract: Background: The repair of a calvarial defect is a challenging procedure, requiring not only filling of the bone gap but long term stability of the employed material and satisfactory contour and symmetry. Several types of materials with different characteristics have been studied, as well as various methods of implant production. However, to date no ideal bone substitute has been found. The osseointegration properties of porous prototyped implants with tridimensionally interconnected pores made of the Ti6Al4V alloy and the influence of a thin layer of calcium phosphate coating were investigated. Methods: Bilateral critical size calvarial defects were produced in thirty rats and filled with coated and uncoated implants in a randomized fashion. The animals were distributed in groups and kept for 15, 45 and 90 days before sacrifice. Implant mechanical integration to bone was evaluated with a push-out test. Bone-implant interface was analyzed using scanning electron microscopy. Results: The maximum force to produce initial displacement of the implants increased during the study period, reaching values around 100N for both types of implants. Intimate contact between bone and implant surface was present, with progressive bone growth into the pores. No significant differences were seen between coated and uncoated implants. Conclusion: Adequate osseointegration can be achieved in calvarial reconstructions using prototyped Ti6Al4V scaffolds with the described physical characteristics of surface and porosity. The results suggest that the proposed implant design characteristics can be incorporated into calvarial implants to improve reconstructive results.
Doutorado
Fisiopatologia Cirúrgica
Doutor em Ciências
D'Aoust, Paul R. "The use of biophosphonates to promote healing of rat calvarial wounds." 1998. http://catalog.hathitrust.org/api/volumes/oclc/48213032.html.
Повний текст джерелаChen, Min-Chia, та 陳敏嘉. "Effect of Computer-designed 3D-Printed Poly ɛ-caprolactone Scaffolds and Plasma-rich fibrin on Bone Formation in Calvarial Defects in Rats". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/4k44kf.
Повний текст джерела國防醫學院
牙醫科學研究所
106
Background: In guiding bone formation, creating an adequate space is critical due to defect complexity. In this study, a polycaprolactones (PCL) scaffold, computer designed and 3D-printed, was implanted into the critical-sized calvaria defect in rat, whereas the effect of plasma-rich fibrin (PRF) on the bone formation was also tested. Methods: Two round defects, 6 mm in diameter, were surgically created in parietal bones of 32 rats, then 4 defect groups, including defect control, PRF, PCL, and PCL-plus-PRF (PRF+PCL), were divided according to scaffold implantation and PRF delivery. Four and eight weeks after, half of the rats were sacrificed, respectively. Bone formation was assessed by dental radiography, micro-computed tomography (µ-CT), and histology. Results: By dental radiography and µ-CT, the radio-opaque row-by-row squares were observed in the defects of PCL and PCL+PRF groups. The opaque areas/volumes, as well as their relative values (areas/volumes), in defects were similar among 4 groups; however, significantly greater values were noted in central, but not peripheral zone in the groups with PCL (PCL and PRF+PCL groups) than those without PCL (defect control and PRF groups). By histology, the bones formed in the spaces between PCL struts; however, there was no bones-struts contact observed. Histometry showed that the tissue areas were significant greater in the groups with PCL than that without, particularly in central zone, in spite of the intervals. In week 8, similar findings were observed, including the bone and connective tissue areas. Similar areas for PCL residuals were observed in the PCL and the PRF+PCL groups. (太長) Conclusions: In the critical-sized calvarial defect of rat, our results showed the bones formed within the spaces supported by the computer-designed 3D-printed PCL scaffold but no contact with PCL struts. Strategy of using the customized scaffold for supporting spaces in augmenting bone formation is therefore suggested.