Дисертації з теми "Calcium Metabolism"
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Eraso, Pichot Abel. "Adaptive regulation of calcium excitability and energy metabolism by CREB-dependent transcription in astrocytes: study of the mechanisms governing astrocyte plasticity." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664170.
An increasing body of evidence suggests that astrocytes participate in higher-brain functions, controlling from synaptic transmission to global brain waves and learning and memory processes. Different mechanisms have been proposed to mediate these astrocyte-dependent processes, astrocytic lactate release and calcium-dependent gliotransmission being the main known effectors. The existence of control of brain functions by astrocytes suggests that astrocytes may shape brain functions in response to experience as much as neurons, thus constituting the phenomenon of astrocyte plasticity. In neurons, the transcription factor CREB is the best known coordinator of synaptic and intrinsic plasticity. The fact that, in astrocytes, CREB activation is also activity-dependent, positions CREB as an ideal target to promote plasticity-related changes in astrocytes, too. In this thesis, we have analyzed the effect of the activation of CREB-dependent transcription in astrocytes, specifically regarding calcium signals and metabolism. We have demonstrated that activation of CREB-dependent transcription reduces cytosolic calcium events via mitochondria and increases in lactate release, which may have impact on synaptic transmission. An important contribution of the study is the molecular analysis of astrocytic mitochondria, which has revealed that astrocytes may use fuels other than glucose such as fatty acids to meet basic energy metabolic demands. Taken together, our results establish astrocytic CREB as a hub in astrocyte-plasticity and shed light on the interplay between plasticity and energy metabolism in astrocytes; these findings constitute a conceptual and mechanistic advance in the knowledge of astrocytic biology and how these cells may control learning and memory.
Johnson, John Drysdale. "Stimulation of mitochondrial metabolism by calcium." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315046.
Redmond, Jean Patricia. "Ethnic differences in calcium, phosphate and bone metabolism." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708405.
O'Loughlin, Peter Damian. "Effects of growth and oophorectomy on calcium balance /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pho516.pdf.
Mody, Istvan. "Calcium regulation in long-term changes of neuronal excitability in the hippocampal formation." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25929.
Medicine, Faculty of
Cellular and Physiological Sciences, Department of
Graduate
Barbosa, Erika Grasiela Marques de Menezes [UNESP]. "Perfil metabólico de cálcio e ósseo de pacientes soropositivos para HIV em uso ou não da terapia antirretroviral." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/88689.
A potência e a eficácia das terapias antirretrovirais (TARV) aumentaram a expectativa de vida dos pacientes infectados pelo vírus da imunodeficiência humana. Entretanto, resultados de vários estudos sugerem que estas terapias também podem produzir modificações metabólicas, tais como as doenças ósseas. O objetivo do presente estudo foi avaliar a qualidade óssea e marcadores de formação e reabsorção óssea em pacientes infectados pelo HIV em uso ou não da TARV. Foi realizado um estudo transversal, com 50 homens adultos, em tratamento ou não com antirretrovirais. Foram aplicados métodos de avaliação do consumo alimentar, medidas antropométricas e avaliação da composição corporal e óssea utilizando a dual energy x-ray absorptiometry (DXA). Para a avaliação bioquímica foram utilizados os marcadores: hormônio do folículo estimulante (FSH), hormônio luteinizante (LH), paratormônio (PTH), testosterona, cálcio total, fósforo, magnésio, albumina, cálcio 24h, creatinina, uréia, fator 1 de crescimento semelhante a insulina (IGF-I), 25 hidroxivitamina D, osteocalcina e deoxipiridinolina urinária. Os resultados obtidos foram escritos na forma de artigo científico, sendo que o primeiro abordou a influência do tempo de uso da TARV na densidade mineral óssea e mostrou uma redução na massa óssea na maioria dos participantes avaliados e o consumo de cálcio foi adequado apenas no Grupo B1 em tratamento há mais de dois anos com antirretrovirais. O segundo artigo abordou o impacto da TARV nos marcadores do metabolismo ósseo e mineral e mostrou valor aumentado no marcador de reabsorção óssea em todos os grupos do estudo. Concluímos que a maioria dos participantes apresentou uma desmineralização óssea, principalmente com maior tempo de uso da TARV da classe de inibidores de transcriptase reversa...
The potency and efficacy of antiretroviral therapies (ART) have increased the life expectancy of HIV-infected patients. However, the results of various studies suggest that these therapies may also produce metabolic modifications such as bone diseases. The objective of the present study was to evaluate the bone quality and the markers of bone formation and reabsorption in HIV-seropositive patients using or not ART. A cross-sectional study was conducted on 50 adult men treated or not with ART. Methods for the evaluation of food consumption were applied, as well as anthropometric measurements and the evaluation of body and bone composition using dual energy x-ray absorptiometry (DXA). The following markers were used for biochemical evaluation: follicle stimulating hormone (FSH), luteinizing hormone (LH), parathormone (PTH), testosterone, total calcium, phosphorus, magnesium, albumin, 24h calcium, creatinine, urea, insulin-like growth factor 1 (IGF-I), 25 hydroxyvitamin D, osteocalcin, and urinary deoxypyridinoline. The results obtained were presented in the form of scientific articles. The first concerned the influence of the time of ART use on bone mineral density and showed a reduction of bone mass in most of the participants evaluated, with calcium consumption being adequate only in Group B1 under treatment with ARVs for more than two years. The second concerned the impact of ART on the markers of bone and mineral metabolism and showed an increase in the bone resorption marker in all study groups. We conclude that most of the volunteers presented bone demineralization, especially after a longer time of use of ART of the nucleoside reverse transcriptase inhibitor class. The increased bone remodeling indicates a greater... (Complete abstract click electronic access below)
Pasanisi, F. "Clinical pharmacology of calcium antagonists." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381477.
Lirvall, Margareta. "Dynamics and gene expression of growth factor receptors in human cultured skin cells : effects of UV radiation and calcium on EGF- and PDGF-receptors /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med674s.pdf.
Efanov, Alexander. "Stimulation of insulin secretion independently from changes in cytosolic free Ca²⁺-concentration : studies with imidazolines and inositol polyphosphates /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3876-8/.
Tsai, Jon A. "Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4174-2.
Madrick, Tracy L. "The availability of calcium from various commercial sources of calcium carbonate and fortified food products." Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/53228.
Master of Science
Beggs, Louise Alice. "Evaluation of the problem solving method in nutrition education." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26164.
Education, Faculty of
Curriculum and Pedagogy (EDCP), Department of
Graduate
Gomes, Rocha Agostinho Manuel. "Calcium regulation in chloroplasts and the role of calcium-dependent phosphorylation of transketolase in carbon metabolism." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-153326.
Ruschkowski, Sharon Rose. "Ovulation and calcium metabolism in white leghorn hens (Gallus gallus)." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29810.
Land and Food Systems, Faculty of
Graduate
Dawes, Michael W. "The formulation and validation of mathematical models of calcium metabolism." Thesis, City University London, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237825.
Takasugi, Satoshi. "The effects of excess calcium on mineral metabolism in rats." Kyoto University, 2009. http://hdl.handle.net/2433/126539.
0048
新制・論文博士
博士(農学)
乙第12384号
論農博第2719号
新制||農||975(附属図書館)
学位論文||H21||N4493(農学部図書室)
27319
UT51-2009-K693
(主査)教授 松井 徹, 教授 久米 新一, 教授 廣岡 博之
学位規則第4条第2項該当
Scheffler, Tracy Leigh. "AMP-activated protein kinase and muscle metabolism." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/38829.
Ph. D.
Fujiwara(Tomita), Kyoko. "Clinical studies of the effect of food components on calcium or lipid metabolism." Kyoto University, 2014. http://hdl.handle.net/2433/193552.
Sampath, Vanitha. "The effects of calcium supplementation on adipocyte metabolism in overweight women /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
Campbell, Karen. "The relationship between calcium and metabolism in mouse eggs at fertilisation." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54106/.
Mohammed, Samir M. M. "Calcium metabolism in sickle cell disease : possible link with sicklaemic osteoporosis." Thesis, University of Salford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292910.
Outila, Terhi. "The effect of vitamin D status on calcium and bone metabolism." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/maa/skemi/vk/outila/.
Martino, Paul F. "The effects of dantrolene on post exercise glucose uptake." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1020145.
School of Physical Education
Batts, Timothy W. "Effects of Reduced Muscle Glycogen on Sarcoplasmic Reticulum (SR), Muscle and Exercise Performance." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/27244.
Ph. D.
Barbosa, Erika Grasiela Marques de Menezes. "Perfil metabólico de cálcio e ósseo de pacientes soropositivos para HIV em uso ou não da terapia antirretroviral /." Araraquara :, 2013. http://hdl.handle.net/11449/88689.
Banca: Alcyone Artioli Machado
Banca: Flavia Queiroga de Almeida
Resumo: A potência e a eficácia das terapias antirretrovirais (TARV) aumentaram a expectativa de vida dos pacientes infectados pelo vírus da imunodeficiência humana. Entretanto, resultados de vários estudos sugerem que estas terapias também podem produzir modificações metabólicas, tais como as doenças ósseas. O objetivo do presente estudo foi avaliar a qualidade óssea e marcadores de formação e reabsorção óssea em pacientes infectados pelo HIV em uso ou não da TARV. Foi realizado um estudo transversal, com 50 homens adultos, em tratamento ou não com antirretrovirais. Foram aplicados métodos de avaliação do consumo alimentar, medidas antropométricas e avaliação da composição corporal e óssea utilizando a dual energy x-ray absorptiometry (DXA). Para a avaliação bioquímica foram utilizados os marcadores: hormônio do folículo estimulante (FSH), hormônio luteinizante (LH), paratormônio (PTH), testosterona, cálcio total, fósforo, magnésio, albumina, cálcio 24h, creatinina, uréia, fator 1 de crescimento semelhante a insulina (IGF-I), 25 hidroxivitamina D, osteocalcina e deoxipiridinolina urinária. Os resultados obtidos foram escritos na forma de artigo científico, sendo que o primeiro abordou a influência do tempo de uso da TARV na densidade mineral óssea e mostrou uma redução na massa óssea na maioria dos participantes avaliados e o consumo de cálcio foi adequado apenas no Grupo B1 em tratamento há mais de dois anos com antirretrovirais. O segundo artigo abordou o impacto da TARV nos marcadores do metabolismo ósseo e mineral e mostrou valor aumentado no marcador de reabsorção óssea em todos os grupos do estudo. Concluímos que a maioria dos participantes apresentou uma desmineralização óssea, principalmente com maior tempo de uso da TARV da classe de inibidores de transcriptase reversa... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The potency and efficacy of antiretroviral therapies (ART) have increased the life expectancy of HIV-infected patients. However, the results of various studies suggest that these therapies may also produce metabolic modifications such as bone diseases. The objective of the present study was to evaluate the bone quality and the markers of bone formation and reabsorption in HIV-seropositive patients using or not ART. A cross-sectional study was conducted on 50 adult men treated or not with ART. Methods for the evaluation of food consumption were applied, as well as anthropometric measurements and the evaluation of body and bone composition using dual energy x-ray absorptiometry (DXA). The following markers were used for biochemical evaluation: follicle stimulating hormone (FSH), luteinizing hormone (LH), parathormone (PTH), testosterone, total calcium, phosphorus, magnesium, albumin, 24h calcium, creatinine, urea, insulin-like growth factor 1 (IGF-I), 25 hydroxyvitamin D, osteocalcin, and urinary deoxypyridinoline. The results obtained were presented in the form of scientific articles. The first concerned the influence of the time of ART use on bone mineral density and showed a reduction of bone mass in most of the participants evaluated, with calcium consumption being adequate only in Group B1 under treatment with ARVs for more than two years. The second concerned the impact of ART on the markers of bone and mineral metabolism and showed an increase in the bone resorption marker in all study groups. We conclude that most of the volunteers presented bone demineralization, especially after a longer time of use of ART of the nucleoside reverse transcriptase inhibitor class. The increased bone remodeling indicates a greater... (Complete abstract click electronic access below)
Mestre
Taylor, Megan Sands. "Calcium and Phosphorus Metabolism in Jersey and Holstein Cows During Early Lactation." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/29118.
Ph. D.
Crouch, Michael Francis. "Inositol phospholipid turnover and pancreatic exocrine secretion /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phc9519.pdf.
James, Andrew. "Metabolic regulation of the plasma membrane calcium pump in pancreatic ductal adenocarcinoma." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/metabolic-regulation-of-the-plasma-membrane-calcium-pump-in-pancreatic-ductal-adenocarcinoma(0533b59c-e6ee-41fb-ad32-cb4784eadfa1).html.
Alomaim, Haya. "Effects of Dietary Calcium on Body Composition and Lipid Metabolism in Rats." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37602.
Takagi, Hiroshi. "Effects of manipulating dietary cation-anion balance on calcium metabolism in sheep." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75683.
Clifton-Bligh, Phillip. "Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18554.
Allen, Bruce Gordon. "Studies on the reaction cycle of the calcium transport atpase from human erythrocytes." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24458.
Pharmaceutical Sciences, Faculty of
Graduate
Koenig, Vicki C. "Effect of calcium level and source on plasma total and lipoprotein cholesterol in men under controlled dietary conditions." Thesis, Virginia Polytechnic Institute and State University, 1987. http://hdl.handle.net/10919/64565.
Master of Science
Hagström, Emil. "Metabolic disturbances in relation to serum calcium and primary hyperparathyroidism /." Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6893.
Challa, J. "Phosphorus and calcium metabolism in growing calves with special emphasis on phosphorus homeostasis." Thesis, University of Reading, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371434.
Шапкін, Вадим Евгенійович, and V. E. Shapkin. "Calcium metabolism changes as a formation mechanism of diabetic foot in geriatric patients." Thesis, ХНМУ, 2017. http://repo.knmu.edu.ua/handle/123456789/15813.
Huo, Jiuzhou. "Regulation of Mitochondrial Calcium Dynamics in Striated Muscle Function." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595846761184679.
Yip, Ming Fai Freddy Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "The role of Myo1c phosphorylation in GLUT4 translocation." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/43648.
Raposo, João Filipe Cancela Santos. "A regulação endócrina dos balanços de cálcio." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2004. http://hdl.handle.net/10362/5523.
Thatcher, Nicola M. "Cerebral metabolism, calcium and zinc during excitotoxic challenge : a multinuclear magnetic resonance spectroscopy study." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260992.
Matsui, Tohru. "The Nutritional and Physiological Role of Calcitonin on Calcium and Phosphorus Metabolism in Sheep." Kyoto University, 1985. http://hdl.handle.net/2433/77697.
Message, Chris. "The effect of modified waxy maize starch on calcium bioavailability, with special reference to the rat." Thesis, Oxford Brookes University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262170.
Andrade, Carolina de Matos Figueiredo de [UNESP]. "Análise do consumo de extato hidrossolúvel de soja na qualidade do tecido ósseo de ratos jovens adultos." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/132935.
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A soja é uma leguminosa rica em proteínas, fonte de cálcio e isoflavonas. Um dos possíveis efeitos das isoflavonas é de reduzir a perda óssea quando há uma deficiência de estrogênio. A proposta desse estudo foi analisar a influência da dieta suplementada com extrato hidrossolúvel de soja (EHS) na massa óssea de ratos adultos jovens de ambos os sexos. Foram utilizados 40 ratos Novergicus Albinus linhagem Wistar adultos jovens e saudáveis, aleatoriamente separados em quatro grupos: macho controle (MC), macho suplementado (MS), fêmea controle (FC) e fêmea suplementada (FS) que permaneceram por 11 semanas em gaiola comum recebendo 500 mL de água e 300g de ração diariamente, os grupos suplementados (MS e FS), ao qual foi oferecido além de água e ração, 500 ml de EHS, durante o mesmo período experimental do controle. O consumo de ração e a ingestão de líquidos foram mensurados, bem como a massa dos animais. Ao final do período os animais foram eutanasiados. Os ossos foram submetidos à densitometria óssea– DXA (osso inteiro e região cortical) e ensaio mecânico, para avaliação da densidade mineral óssea - DMO (g/cm2), Força Máxima (N) e Rigidez (kN/m). Na análise de grau de mineralização foi utilizado as cinzas para quantificar de concentração de cálcio e fósforo. O consumo de EHS provocou diminuição da DMO no grupo MS, porém não houve alteração nas propriedades biomecânicas, força máxima e rigidez. A concentração de cálcio e fósforo nas cinzas dos fêmures do grupo MS foi significantemente menor que o grupo controle. Conclui-se assim, que o extrato hidrossolúvel de soja influenciou negativamente o conteúdo mineral ósseo de ratos machos jovens adultos diminuindo a mineralização, sem alterar as características mecânicas.
Soybeans are a rich legume protein, a source of calcium and isoflavones. One of the possible effects of isoflavones is to reduce bone loss when it was estrogen deficiency. The purpose of this study was to analyze the influence of diet supplemented with soybean’s hydro soluble extract (SHE) in bone mass in young adults rats of both genders. Were used 40 rats Novergicus Albinus Wistar young and healthy, randomly separated into four groups: male control (MC) and female control(FC), which remained for 11 weeks in common cage receiving 500 ml of water and 300 g of feed daily, and the others supplemented groups; male supplemented (MS) and female supplemented, that was offered in addition to water and feed 500ml of SHE. During the experimental period, feed intake and intake of liquids were measured as well as the mass of animals. At the end, the animals were euthanized. The bones underwent bone densitometry – DXA(whole bone and cortical area) and mechanical testing for bone mineral density - BMD (g / cm 2) Maximum Strength (N) and stiffness (kN / m), respectively. To analyze the mineralization degree was used bone ashes to quantify calcium and phosphorus concentration. The consumption of SHE caused decreased of BMD in MS group, but there were no changes in the bone biomechanical properties, maximum strength and rigidity. Concluding that the water extract of soy beans negatively affected the bone mineral content of young adult males rats decreasing the mineralization degree without changing the mechanical characteristics.
Andrade, Carolina de Matos Figueiredo de. "Análise do consumo de extato hidrossolúvel de soja na qualidade do tecido ósseo de ratos jovens adultos /." Araçatuba, 2016. http://hdl.handle.net/11449/132935.
Banca: Paulo César Ciarlini
Banca: Cáris Maroni Nunes
Resumo: A soja é uma leguminosa rica em proteínas, fonte de cálcio e isoflavonas. Um dos possíveis efeitos das isoflavonas é de reduzir a perda óssea quando há uma deficiência de estrogênio. A proposta desse estudo foi analisar a influência da dieta suplementada com extrato hidrossolúvel de soja (EHS) na massa óssea de ratos adultos jovens de ambos os sexos. Foram utilizados 40 ratos Novergicus Albinus linhagem Wistar adultos jovens e saudáveis, aleatoriamente separados em quatro grupos: macho controle (MC), macho suplementado (MS), fêmea controle (FC) e fêmea suplementada (FS) que permaneceram por 11 semanas em gaiola comum recebendo 500 mL de água e 300g de ração diariamente, os grupos suplementados (MS e FS), ao qual foi oferecido além de água e ração, 500 ml de EHS, durante o mesmo período experimental do controle. O consumo de ração e a ingestão de líquidos foram mensurados, bem como a massa dos animais. Ao final do período os animais foram eutanasiados. Os ossos foram submetidos à densitometria óssea- DXA (osso inteiro e região cortical) e ensaio mecânico, para avaliação da densidade mineral óssea - DMO (g/cm2), Força Máxima (N) e Rigidez (kN/m). Na análise de grau de mineralização foi utilizado as cinzas para quantificar de concentração de cálcio e fósforo. O consumo de EHS provocou diminuição da DMO no grupo MS, porém não houve alteração nas propriedades biomecânicas, força máxima e rigidez. A concentração de cálcio e fósforo nas cinzas dos fêmures do grupo MS foi signific... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Soybeans are a rich legume protein, a source of calcium and isoflavones. One of the possible effects of isoflavones is to reduce bone loss when it was estrogen deficiency. The purpose of this study was to analyze the influence of diet supplemented with soybean's hydro soluble extract (SHE) in bone mass in young adults rats of both genders. Were used 40 rats Novergicus Albinus Wistar young and healthy, randomly separated into four groups: male control (MC) and female control(FC), which remained for 11 weeks in common cage receiving 500 ml of water and 300 g of feed daily, and the others supplemented groups; male supplemented (MS) and female supplemented, that was offered in addition to water and feed 500ml of SHE. During the experimental period, feed intake and intake of liquids were measured as well as the mass of animals. At the end, the animals were euthanized. The bones underwent bone densitometry - DXA(whole bone and cortical area) and mechanical testing for bone mineral density - BMD (g / cm 2) Maximum Strength (N) and stiffness (kN / m), respectively. To analyze the mineralization degree was used bone ashes to quantify calcium and phosphorus concentration. The consumption of SHE caused decreased of BMD in MS group, but there were no changes in the bone biomechanical properties, maximum strength and rigidity. Concluding that the water extract of soy beans negatively affected the bone mineral content of young adult males rats decreasing the mineralization degree without c... (Complete abstract click electronic access below)
Mestre
Santini, Olivier. "Effects of copper on calcium metabolism and detoxification mechanisms in freshwater bivalve species of "Anodonta." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0397/document.
Copper (Cu) belongs to the major metals causing environmental contamination in European fresh water ecosystems. Filter feeding bivalves have a high bioaccumulation potential for heavy metals as Cu, which at high concentration can cause serious metabolic, physiological impairments. The objectives of this thesis are to acquire knowledge about toxic effects and detoxification mechanisms of Cu in Anodonta cygnea and Anodonta anatina, two mussels species widely distributed in continental waters. Because calcium (Ca) plays a fundamental role in numerous biological processes, Cu effect was studied first on cellular calcium transport which is known to be disturbed by Cu in molluscs. In a second step, investigations have been carried out on Cu detoxification mechanisms by thiol compounds known to be involved in homeostasis of essential trace metals and in metals cell detoxification. Cu inhibited plasma membrane Ca2+-ATPase (PMCA) activities upon 4 days of exposure was obtained. Total recovery was observed at day 7 in kidneys and gills under exposure to environmental Cu concentration but not at higher level of exposure. PMCA inhibition may entail disturbance of osmo-regulations and calcium renal re-uptake in mussels and lead to continuous under-supply of Ca. Recovery of the enzyme function suggests that metal-detoxification is induced. Our results showed the presence of a cysteine-rich peptide different from glutathione, detected in the digestive gland and the gills from controls and Cu exposed bivalves. This peptide, observed in absence of metal exposure in both organs, increased significantly in gills after Cu exposure suggesting its implication in Cu detoxification mechanisms
Anderson, Paul Hamill. "The regulation of Vitamin D metabolism in the kidney and bone." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09pha5486.pdf.
Li, Yiming. "Ryanodine receptors in calcium signaling pathways." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/710.
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