Дисертації з теми "Calcium-deficient"
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Zhou, Huan. "Multi-Functions of Carbonated Calcium Deficient Hydroxyapatite (CDHA)." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1332947663.
Повний текст джерелаHauser, Holly. "Attempts to create rickets in mice using a calcium deficient diet." Connect to resource, 2007. http://hdl.handle.net/1811/24829.
Повний текст джерелаTitle from first page of PDF file. Document formatted into pages: contains 11 p.; also includes graphics. Includes bibliographical references (p. 10-11). Available online via Ohio State University's Knowledge Bank.
Cifelli, Carlo. "Impairment of force development in K(ATP) channel deficient skeletal muscle involves calcium ion influx through L-type calcium ion channels." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27342.
Повний текст джерелаTin, Ekun. "Changes in Iron, Calcium, Magnesium, Copper and Zinc Levels in Different Tissues of Riboflavin Deficient Rats." Kyoto University, 1997. http://hdl.handle.net/2433/202193.
Повний текст джерелаAksu, Ceren. "The Role Of Calcium Ion On Activated Sludge Biochemical And Physical Properties In Phosphorus Deficient Growth Medium." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612580/index.pdf.
Повний текст джерелаZhang, Joachim Yaxin [Verfasser]. "Calcium regulation in normal and dystrophin-deficient muscle and the role of TRP channels / Joachim Yaxin Zhang." Greifswald : Universitätsbibliothek Greifswald, 2016. http://d-nb.info/1106150414/34.
Повний текст джерелаAkiyama, Norihiro. "Difference between Dogs and Rats with regard to Osteoclast-like Cells in Calcium-deficient Hydroxyapatite-Induced Osteoinduction." Kyoto University, 2011. http://hdl.handle.net/2433/142091.
Повний текст джерелаChaistitwanich, Rachaneeporn. "The Effect of Dietary Calcium and Phosphorus Levels on Audiogenic Seizure Susceptibility and Brain Neurotransmitters in Magnasium Deficient Rats." DigitalCommons@USU, 1986. https://digitalcommons.usu.edu/etd/5330.
Повний текст джерелаPicard, Quentin. "Biomatériaux hybrides : tissu de fibres de carbone / phosphates de calcium : synthèse, caractérisation et biocompatibilité." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2073/document.
Повний текст джерелаThis work is focused on the synthesis of a novel hybrid biomaterial made of carbon fibers cloth (CFC)/ calcium phosphates (CaP) using the sono-electrochemical technique and the study of the influence of experimental parameters on the chemical composition, microtexture and structure of CaP deposits and on in vitro biocompatibility. Current density is shown to be a crucial parameter. Specifically, at high current densities ((≥ 100 mA/g), the fast water electrolysis rate leads to a needle-like deposit consisting in a major phase of carbonated calcium deficient hydroxyapatite (CaD-HAP) mixed with a calcium carbonate phase. At low current densities (≤ 50 mA/g), the slow water electrolysis rate generates a plate-like carbonated CaD-HAP phase, coming from the in situ hydrolysis of a former octacalcium phosphate phase. Whatever the experimental conditions, particles of the deposits consists in a carbonated CaD-HAP core showing an ordered structure, surrounded by a hydrated and disordered carbonated CaD-HAP surface layer which results of the formation of oversaturated domains during CaP precipitation. Sono-electrodeposition is shown to be a versatile process able to control the nature of CaP phases. Especially, at low current density a biomimetic CaP deposit is obtained, similar to the mineral part of bones produced during natural osteogenesis. In vitro biologic tests using primary human osteoblasts showed that the nano-porosity and hydrophilicity of the carbon fibers do not affect the biocompatibility and that fiber precursor, sizing and lobe shaped fibers seems to favor adhesion and proliferation of human cells
Chandler, Catherine. "Spectroscopy of exotic f - p - g nuclei using projectile fragmentation and fusion evaporation reactions." Thesis, University of Surrey, 1999. http://epubs.surrey.ac.uk/843034/.
Повний текст джерелаSandulache, Diana Maria. "Renal function of kinase deficient mice." [S.l. : s.n.], 2007.
Знайти повний текст джерелаSouza, Diego Clemente de. "Biocompósitos eletrofiados de PLLA com alto conteúdo de partículas de fosfatos de cálcio funcionalizados para regeneração óssea." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-14122017-134506/.
Повний текст джерелаThis work aimed at the generation of scaffolds for cellular growth constituted by poly(L-lactide) (PLLA) and several types of calcium phosphate (CaP). Calcium deficient hydroxyapatite (HAD) and octacalcium phosphate (OCP) were synthesized in submicrometer sizes. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) were purchased from Sigma-Aldrich. A mixture of HAD:β-TCP (7:3) also was prepared. In order to improve the dispersion of the mineral phase in a PLLA polymeric matrix, lauroyl chloride was used to functionalize the surface of CaP. Infrared spectra and thermal gravimetric analysis confirmed the presence of laurate on the surface of CaP particles. Neat HA particles were also functionalized with lauryl chloride for comparative purposes. Composites of PLLA/CaP-laurate were fabricated by electrospinning method. The functionalization of CaP surfaces resulted in significant improvement of the dispersion of CaP particles into the polymeric matrix, allowing inclusion of up to 40% of mineral phase without compromising its mechanical properties. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed to investigate the morphology of the fibers. The mass loss and calcium release of the scaffolds during degradation in phosphate buffered saline (PBS) were measured. HAD and OCP are more soluble than HA and HAD:β-TCP (7:3). The bioactivity of the composites was investigated by immersing the fibers in a simulated body fluid (SBF) at 37°C and pH 7.4. Although all PLLA/CaP-laurate can form apatite precipitation on their surface after exposition to SBF, the results demonstrate a significant enhancement in the mineralization when HAD, OCP and HAD:β-TCP (7:3) are the mineral phase in the composite instead of HA. Furthermore, mats obtained from PLLA/CaP-laurate electrospun fibers favored the mouse fibroblast cells (NIH-3T3) and stem cells from human exfoliated deciduous teeth (SHED) attachment and proliferation. Finally, PLLA/HAD-laurate and PLLA/OCP-laurate meshes showed better performance in accelerate the calcium phosphate mineralization on its surface as a result of the in vitro osteoinduction of SHEDs and calvaria derived mouse preosteoblastic cells (MC3T3-E1) if compared of those containing HA and HAD:β-TCP (7:3). These new materials are proposed as fast degradation CaP biocomposites to be used in bone regeneration applications in orthodontics and orthopedics.
Olivier, Florian. "Elaboration, caractérisation, dopages et évaluations in vitro et in vivo de matériaux hybrides : Tissus de fibres de carbone / Phosphates de calcium." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2052/document.
Повний текст джерелаOptimization of the synthesis of calcium phosphates (CaP) on carbon fiber cloths (TFC) was performed in using sono-electrodeposition process in order to obtain uniform coatings. The electrochemical potential applied and the electrolyte temperature during the synthesis were determined as being key parameters. For a constant potential of -1 V at 70 ° C, a controlled water electrolysis regime results in the deposit of plate-like calcium-deficient apatite (CDA). This plate-like particles (from a few tens to hundreds of nm in length) consist in an ordered structure of carbonated CDA in their core and in a disordered structure in the hydrated surface, a typical organization of biomimetic apatites. The hybrid material was doped with strontium, resulting in a carbonated CDA coating where the Ca²+ ions are controllably substituted by Sr²+ ions, leading to new properties for a bone regeneration application. This work has also shown the possibility of selectively adsorb targeted active molecules (tetracycline, naproxen, aspirin) in each component of the hybrid material. The desorption curves revealed two modes of release depending on the active molecule.A biological evaluation of the different hybrid materials was carried out. The in vitro study investigated the viability and proliferation of human osteoblasts at the surface of hybrid materials, demonstrating their biocompatibility. The interest of a doping (Sr²+, aspirin and naproxen) on osteoblast activity was demonstrated. An in vivo pilot experiment was conducted, through the creation of a bone defect in rat thighbones to study the influence of TFC/CaP biomaterials on the quantitative and qualitative evolutions of bone regeneration
Berna, Erro Alejandro. "Generation and Characterization of Stromal Interaction Molecule 2 (STIM2)-deficient Mice." kostenfrei, 2009. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-47301.
Повний текст джерелаKozel, Peter J. "HEARING IMPAIRMENTS IN MICE DEFICIENT IN PLASMA MEMBRANE Ca 2+ - ATPASE ISOFORM 2." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin991749321.
Повний текст джерелаColonese, André. "Avaliação de propriedades mecânicas e térmicas de compósito à base de polietileno de alta densidade e hidroxiapatita deficiente de cálcio." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8492.
Повний текст джерелаIn this work, composites of high density polyethylene HDPE with calciumdeficient hydroxyapatite were synthesized in order to obtain materials with good mechanical properties and bioactivity. The addition of calcium-deficient hydroxyapatite resulted in an increase in elastic modulus (high rigidity), lower impact resistance and lower HDPE crystallinity degree, promoting, in these materials, a higher bioactivity. Scanning thermal analysis (non-isothermal system) was carried out by differential scanning calorimetry (DSC), and it was evaluated the calcium phosphate content added and the screw speed in the processing. In non-isothermal crystallization studies it was observed a decrease in crystallization temperature as the cooling rate was increased for all produced materials. The activation energy of crystallization was evaluated by Kissinger and Ozawa methods. The sample with 5 wt.% of calcium-deficient hydroxyapatite and processed at 200 rpm screw speed showed the lower value of activation energy (262 kJ/mol) and the lower deviation from linearity. Calcium-deficient hydroxyapatite does not promote the crystallization process due to the high activation energy determined by the described methods. Probably the screw speed promotes the dispersion of the filler in the HDPE matrix and hinders the crystallization process. Correlation coefficients in Osawa-Avrami method indicated loss in the linear correlation. These losses might be associated with a small percentage of secundary crystallization and/or the temperatures chosen to determine the crystallization rate. The parameters obteined from Mo method, the lower percentages of crystallization showed a great deviation from linearity, with correlation coefficient much smaller than 1, when increasing the percentage of crystallization, the deviation from linearity decreases, getting closer to 1.The results of Mo and Osawa-Avrami models were not able to set the kinetic behavior of the materials produced in this study.
Selvin, David. "Regulation of Myoplasmic Ca2+ During Fatigue in KATP Channel Deficient FDB Muscle Fibres." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26174.
Повний текст джерелаHutchens, Stacy. "Characterization of a Biomimetic Calcium-Deficient Hydroxyapatite-Bacterial Cellulose Composite." 2007. http://etd.utk.edu/2007/HutchensStacy.pdf.
Повний текст джерелаHutchens, Stacy. "Synthesis and initial characterization of a calcium-deficient hydroxyapatite-bacterial cellulose composite." 2004. http://etd.utk.edu/2004/HutchensStacy.pdf.
Повний текст джерелаTitle from title page screen (viewed May 14, 2004). Thesis advisor: Richard Jendrucko. Document formatted into pages (ix, 77 p. : ill. (some col.)). Vita. Includes bibliographical references (p. 68-74).
Ping-ChouHsieh and 謝秉舟. "Evaluation of tetracycline loaded calcium deficient hydroxyapatite for integrated anti-microbial activity." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/99u3cf.
Повний текст джерела國立成功大學
口腔醫學研究所
106
Peri-implantits is a major risk factor for late dental implants failures. Traditional remedy usually failed to eliminate pathogens completely due to biofilm covering the titanium surface. In this study, we developed a nano calcium-deficient hydroxyapatite (CDHA) carrier intended for extended tetracycline (TC) release to disrupt biofilm on the implant surface while simultaneously enhance new bone regeneration for peri-implantitis treatment. The tetracycline-loaded CDHA nanoparticles (TC-CDHA) were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and dynamic light scattering (DLS). The TC-CDHAs were then evaluated for anti-bacteria potency by determine their minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of pathogens. The TC-CDHA presented as round, less than 100nm rod shape particles under SEM and TEM. The crystalline size measured by Scherrer’s formula is about 10.8nm x 4.62nm. We discovered that the loading capacity of TC was 86.23%. Tetracycline is well embedded in the CDHA as revealed by EDS examination. Anti-bacterial assay showed that the MIC of the drug loaded nanoparticles are comparable to that of the freeform TC (86.25% for TC vs. 89.47% for TC-CDHA) when both were at TC concentration of 0.1ug/ml. This study revealed that the as prepared TC-CDHA has similar potency as freeform TC while may harbor additional advantages for stimulating bone regeneration. Such nanomedicine holds a promising future for peri-implantitis treatment.
Li, Jo-Hao, and 李若豪. "The physical properties and drug permeation of nanosize Calcium-deficient Hydroxyapatite/Chitosan composites." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/vjcgw2.
Повний текст джерелаWei, Tzu-Hsuan, and 魏子軒. "SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES LOADED EUROPIUM DOPING CALCIUM-DEFICIENT HYDROXYAPATITE NANOROD for IMAGING and TARGETED DELIVERY." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/u4a5pb.
Повний текст джерела大同大學
材料工程學系(所)
107
Development of biocompatible and multifunctional nanovehicle has recently attracted much attention for cancer theranostics. In this study, super paramagnetic iron oxide nanoparticle (SPION) nanorod clusters coated with europium doping calcium-deficient hydroxyapatite- polyethylenimine (Eu:de-HAP-PEI) are synthesized through co-precipitation process to form core/shell nanostructure. The luminescent SPION@Eu:de-HAP-PEI nanorods are explored for the loading and controlled delivery of drugs. The photoluminescence (PL) intensity of SPION@Eu:de-HAP-PEI nanorods can be adjusted by varying Eu3+ concentrations. The magnetic property of SPION@Eu:de-HAP-PEI nanorods increase with the increase of SPION weight ratio. More importantly, the SPION@Eu:de-HAP-PEI nanorods show high drug encapsulation capacity and sustained drug release profile, which is governed by diffusion phenomenon. The SPION@Eu:de-HAP-PEI nanorods exhibit magnetic-targeted characteristic, high drug loading content, high toxicity to tumor cells, low side effects to normal cells, and PL imaging functions. These findings prove that the SPION@Eu:de-HAP-PEI nanorods have great potential as novel tumor-targeting theranostic agents for simultaneous PL imaging and efficient anti-tumor treatment.
Wu, Fan. "Development of biocomposite scaffolds and injectable biocement for bone regeneration." Thesis, 2013. http://hdl.handle.net/2440/80624.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Chemical Engineering, 2013
AN, WU LI, and 吳禮安. "Role of Reactive Oxygen Species (ROS) and Mitochondria Calcium Overloading on the Folic Acid Deprivation-Triggered Apoptosis of Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Human Foreskin Fibroblasts." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51443919650091922411.
Повний текст джерела長庚大學
醫學生物技術研究所
94
Glucose-6-phosphate dehydrogenase (G6PD) is involved in the generation of NADPH for the proper maintenance of the cellular redox balance, G6PD deficiency predispose human fibroblasts (HFF) to retarded growth and accelerated cellular senescence. Thus far, the pivotal role of a micronutrient, such as folic acid, on the cellular functions of the normal and G6PD-deficient HFF have never been investigated. The objectives of the present research are two-fold: (1) To explore the possibility that folic acid deficiency can trigger the occurrence of apoptotic cell death in G6PD-deficient as well as G6PD-normal HFFs. Emphasis will be to elucidate if folate deficiency-induced apoptosis involves reactive oxygen species (ROS)-mediated mitochondrial calcium overload pathway; (2) Real time analysis of living intact cell in single cell level to address the questions if glutathione (GSH) depletion and lipid peroxidation are involved in the very early responses of both HFF-1 and HFF-3 fibroblasts to folate deficiency-induced apoptosis using probe-based confocal fluorescence imaging technique. Furthermore, the possibility as to whether or not the mitochondria calcium overload plays a pivotal role in arbitrating apoptotic process will be addressed in this project. Using DCF-DA as the fluorescence probe, we first monitored the production of mitochondrial ROS (mROS) in both types of fibroblasts cultivated under folate-deficiency condition. Our data indicated that HFF-1 cells (G6PD-deficient cells) produced substantially higher amounts of mROS than their folate-sufficient counterparts (HFF-3 cells) cultivated under folate-deficiency condition seven days. Next, using CMF-DA and BODIPY as the probes, we can able to attest that the folate-deficiency condition (7th day) could elicit GSH depletion and lipid peroxidation in the very early response of both types of fibroblasts to folate-induced oxidative stress situation. Using Fluo-4 (for cytosolic Ca++ probe ) and Rhod-2 (for mitochondrial Ca++ probe) as the probes, we also measured the temporal and spatial distribution of Ca++. In this study, we found that only HFF-1 cells had had increased quantity of Ca++ accumulation as reflected by the increased exhibition of the Rhod-2-mediated orange colored fluorescence. These data attested that mitochondrial calcium overload (mCa++) was the major contributing factor for increased susceptibility of HFF-1 cells to folate deficiency-induced apoptosis as compared to their folate-sufficient counterparts. In parallel, we also found out that increased mCa++ levels correlated with the loss of mitochondrial membrane potential (Δψm). Taken together, our data indicated folate-deficient fibroblasts was mediated via early ROS-evoked GSH depletion and lipid peroxidation and lipid peroxidation resulting in membrane damages. This was followed by a sudden inflex of Ca++ into mitochondria and thus Δψm changed leading to the eventual occurrence of apoptosis. G6PD-deficeincy rendered fibroblasts more prone to folate deficiency-induced apoptosis because of the double stresses situation imposed on these cells.
Erro, Alejandro Berna. "Generation and Characterization of Stromal Interaction Molecule 2 (STIM2)-deficient Mice." Doctoral thesis, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-47301.
Повний текст джерелаDer Anstieg des cytosolischen Ca2+-Spiegels ([Ca2+]i) ist ein Schlüsselereignis, das vielen Signalkaskaden, durch extrazellulären Stimulus ausgelöst werden, nachgeschalten ist, und eine große Reihe zellulärer Prozesse reguliert, z.B. die Aktivierung von Blutplättchen. Eukaryotische Zellen erhöhen ihren basalen ([Ca2+]i) durch Einstrom von extrazellulärem Ca2+ in die Zelle hinein, was durch verschiedene Mechanismen geschehen kann. Store-operated Ca2+-entry (SOCE), wird als der Hauptmechanismus für den Einstrom von extrazellulärem Ca2+ in nicht elektrisch-erregbaren Zellen sowie Plättchen angesehen und beinhaltet einen initialen Ca2+-Ausstrom aus intrazellulären Speichern der dem Ca2+-Einstrom aus der Extrazellulärraum vorrausgeht. Obwohl die Beziehung zwischen Ca2+-Ausstrom aus intrazellulären Speichern und extrazellulärem Ca2+-Einstrom über die Plasmamembran viele Jahre bekannt war, so blieb doch das beide Ereignisse verknüpfende Element unbekannt. Im Jahre 2005 jedoch wurde Stromal Interaction Molecule 1 (STIM1) als Ca2+-Sensor des endoplasmatischen Retikulums (ER) und als essentieller Bestandteil für inositol(1,4,5)-triphosphat (IP3)-vermittelten SOCE in vitro identifiziert. Die Funktion seines Homologs, STIM2, in der Ca2+ Homeostase blieb jedoch unklar. Aus diesem Grund generierten wir STIM2-defiziente (Stim2-/-) Mäuse um die Funktion dieses Proteins in Blutplättchen und Immunzellen untersuchen zu können. Bis zum Erwachsenenalter entwickelten sich Stim2-/- Mäuse normal in Bezug auf Größe und Gewicht und waren fertil. Jedoch sterben die Tiere spontan aus unbekannten Gründen, beginnend ab einem Alter von 8 Wochen. Unerwarteter Weise, zeigten Stim2-/- Mäuse keine maßgeblichen Funktionsunterschiede in Plättchen, was eine essentielle Funktion von STIM2 in diesen Zellen ausschließt. Jedoch scheint STIM2 in die Entwicklung der Brustdrüsen während der Schwangerschaft involviert und essentiell für die Brustdrüsenfunktion während der Säugephase zu sein. Darüberhinaus zeigten STIM2 defiziente CD4+ T-Zellen einen verminderten SOCE. Weiter deuten unsere Daten auf eine spezifische Funktion von STIM2 im Immunsystem hin, mit einem Einfluss auf die frühen Phasen und das Fortschreiten der Experimentellen Autoimmun-Enzephalomyelitis (EAE). Stim2-/- Neuronen wiesen ebenso wie CD4+ T-Zellen einen gestörten SOCE auf. Desweiteren belegen unsere Ergebnisse, dass STIM2 überrascherweise an den Neuronen zerstörenden Mechanismen nach ischämischen Ereignissen des Gehirns mitwirkt. Dies ist die erste Studie, die von einer Beteiligung von SOCEan ischämischen neuronalen Schäden berichtet. Diese Entdeckungen können vielleicht als Basis für die Entwicklung neuer neuroprotektiver Medikamente bei ischämischen Schlaganfall dienen - und möglicherweise auch bei anderen neurodegenerativen Erkrankungen, bei denen Störungen der zellulären Ca2+ Homöostase als hauptsächliche pathophysologische Komponente angesehen werden