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Дисертації з теми "Calcium channel drugs"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 31 липня 2025

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1

Young, Lois-May. "Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration / Young L." Thesis, North-West University, 2012. http://hdl.handle.net/10394/7591.

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Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events that lead to apoptotic and/or necrotic cell death. Increases in the intracellular free calcium concentration ([Ca2+]i) may be the result of Ca2+ influx from the extracellular environment or Ca2+ release from intracellular Ca2+ stores such as the endoplasmic reticulum (ER). Influx from the extracellular environment is controlled predominantly by voltage gated calcium channels (

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2

Zhang, Changfeng. "Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model." Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/142.

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There is significant interest in the field of neuroscience to gain a better understanding of how neurons die in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. We have used the neuronal cell line NG115-401L with unique calcium signaling characteristics to test the hypothesis that improving calcium loading into the endoplasmic reticulum (ER) to increase ER calcium levels acts as a possible neuroprotective response. We approached this problem using both pharmacological and genetic approaches targeting the central mediator of calcium uptake in the ER localized sarco/endop

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3

Kannancheri, Puthooru Dheeraj. "Calcium Channels in Prostate Cancer Drug Resistance." Electronic Thesis or Diss., Université de Lille (2022-....), 2025. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2025/2025ULILS100.pdf.

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Malgré des avancées scientifiques significatives, la guérison du cancer reste une question complexe. Cela est dû non seulement à l'hétérogénéité des tumeurs, mais aussi à l'émergence d'une résistance à la plupart, sinon tous les traitements anticancéreux. Le cancer de la prostate (PCa), qui représente le deuxième cancer le plus fréquent chez les hommes, n'est pas différent: les thérapies conventionnelles, y compris l'hormonothérapie et la chimiothérapie, échouent face à des tumeurs réfractaires. Cette situation rend nécessaire l'élaboration de nouvelles stratégies pour lutter contre ce problèm

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4

Ruchala, Iwona. "EXPANDING MONOAMINE TRANSPORTERS PHARMACOLOGY USING CALCIUM CHANNELS." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5032.

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Research in drug development meets many challenges including lengthy, complex and costly procedures to identify novel pharmacotherapies. In our lab, we developed a method for fast screening of small molecules that interact with monoamine transports – dopamine and serotonin (DAT, SERT). These membrane proteins play important roles in brain neurotransmission responsible for cognition, motion and pleasure. Dysfunction in dopaminergic and serotonergic systems result in neurological disorders such as depression, Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia and addiction. DAT and S

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5

Dowell, Margaret Anne. "Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications." Columbus, Ohio : Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1030118543.

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Анотація:

Thesis (M.S.--Ohio State University, 2002.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 173 p.: ill. Includes abstract and vita. Co-advisors: Craig A. Pedersen, Dept. of Pharmacy; Anne Scheck McAlearney, School of Public Health. Includes bibliographical references (p. 169-173).

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6

Herzinger, Thomas Andreas. "Effects of the Cardioprotective Drugs Dexrazoxane and ADR-925 on Doxorubicin Induced Ca2+ Release from the Sarcoplasmic Reticulum." PDXScholar, 1996. https://pdxscholar.library.pdx.edu/open_access_etds/5069.

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The sarcoplasmic reticulum is the intramuscular organelle responsible for the regulation of cytoplasmic calcium levels in muscle. This thesis investigates the effects of the cardioprotective drug, dexrazoxane, and its metabolite ADR-925 on doxorubicin induced calcium release from skeletal sarcoplasmic reticulum. Doxorubicin is a widely used antineoplastic agent. One of the major side effects of doxorubicin usage is chronic cardiotoxicity. Doxorubicin is a potent activator of the calcium release mechanism from the SR. The interaction between doxorubicin and the calcium release channel has been

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7

Whittington, Miles A. "The ethanol withdrawal syndrome : a role for dihydropyridine-sensitive calcium channels in neural hyperexcitability states." Thesis, University of Bristol, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279774.

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8

Brown, Jason Peter. "The novel antiepileptic drug, gabapentin (Neurontin), binds to the α₂δ subunit of a voltage-dependent calcium channel". Thesis, University of Cambridge, 1996. https://www.repository.cam.ac.uk/handle/1810/252157.

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9

Florent, Romane. "Intérêt de la modulation pharmacologique des voies de signalisation calcique pour restaurer le contrôle de l'apoptose dans les cancers ovariens chimiorésistants Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BclxL strategies through Mcl-1 down-regulation Drug Repositioning of the α1-Adrenergic Receptor Antagonist Naftopidil: A Potential New Anti-Cancer Drug? Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib". Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC413.

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Анотація:

Le sombre pronostic du cancer de l’ovaire s’explique notamment par une fréquence importante de résistance à la chimiothérapie conventionnelle présentée par les patientes. La mise en place de stratégies thérapeutiques alternatives à la chimiothérapie, mais aussi la découverte de biomarqueurs prédictifs de la réponse à ce traitement, représentent donc un enjeu majeur pour améliorer la prise en charge de cette pathologie. La chimiorésistance des cellules cancéreuses ovariennes s’explique principalement par leur résistance à l’apoptose, résultant d’un déséquilibre entre les membres pro- et anti-ap

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10

Olah, Mark E. "Effects of calcium channel blockade and intracellular calcium antagonism on endothelium-dependent responses of the isolated rat aorta and influence of the endothelium on drug action /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487590702989006.

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11

Zhang, Yi. "Potential impact of breast cancer resistance protein on drug disposition during pregnancy /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7970.

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12

Selvey, Christine Enid. "Comparative effects of calcium channel antagonism and beta-1 selective blockade on exercise performance in physically active hypertensive patients." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26736.

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Анотація:

The current recommendations by the American Heart Association for health promotion are that all persons should partake in regular physical activity in order to reduce the risk of cardiovascular disease. Regular physical exercise reduces blood pressure and is an important component of the management of hypertension. It is therefore important that patients with hypertension participate in habitual physical exercise. Many hypertensive patients who exercise will require anti-hypertensive medication. However, some antihypertensive agents cause fatigue during exercise. In order for patients to gain

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13

Wynne, Patricia M. "Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/399.

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BK channels are well studied targets of acute ethanol action. They play a prominent role in neuronal excitability and have been shown to play a significant role in behavioral ethanol tolerance in invertebrates. The focus of my work centers on the effects of alcohol on the BK channel and comprises studies that examine how subcellular location affects acute ethanol sensitivity and how duration of acute alcohol exposure impacts the development of rapid tolerance. My results also provide potential mechanisms which underlie acute sensitivity and rapid tolerance. I first explore BK channel sensitivi

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14

Feinberg-Zadek, Paula Leslie. "Alcohol Modulation of Human BK Channels Evidence for β-Subunit Dependent Plasticity in Functional Ethanol Tolerance: A Dissertation". eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/195.

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Alcoholism is responsible for more than 6% of deaths internationally per annum. The development of acute tolerance to ethanol (EtOH) is a critical component of alcoholism. Previous studies identified large conductance calcium-activated potassium (BK) channels as potential EtOH targets in a variety of species and cells. In order to elucidate mechanisms underlying tolerance development, I used inside-out patch clamp techniques to measure EtOH induced changes in channel activity (measured as open probability) of hSlo, hSlo+β1, and hSlo+β4 channels exogenously expressed in HEK 293 cells. I show th

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15

Assadian, Sarah. "Rodent FDG-PET imaging for the pre-clinical assessment of novel glioma therapies." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101836.

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The rapid discovery of novel therapeutic agents, targeting the specific mechanism of cancer progression, invasion and angiogenesis, necessitates the development and validation of efficient techniques to assess the therapeutic efficacy of these drugs in vivo. Recently the development of dedicated PET scanners for the imaging of small animals, such as the microPET system (CTI Concorde R4), has allowed for the high-resolution functional and molecular imaging of murine and rodent models of disease. This study, investigates the ability of microPET imaging, using the 18F labelled 2-fluoro-2-deoxyglu

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16

Chao, Su-Hui, and 趙素慧. "Photosensitivity drugs(I) Photodegradation of calcium channel blockers(II) Photoproducts of NSAIDs and their anti-inflammatory activities." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/89841605521014148399.

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博士<br>臺北醫學大學<br>藥學研究所<br>95<br>Photosensitivity is a commonly adverse effect of drugs. The purpose of the first part of this study is focus on the photodegradation of nicardipine. When nicardipine was exposed to the Hg lamp, eight photoproducts of nicardipine were identification by LC/MS. The main degraded product was a pyridine analogue (NIC-7). Nicardipine apparently undergoes a series of nitro group photo-reduction pathways under irradiation leading to a complex formation of mainly the reduced products. A reaction scheme of nicardipine was proposed. The second part, gives a study on the ph

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17

Tong, Clement Tsz-Ming. "Comparison of drug blockade of a neuronal calcium-activated potassium channel with cardiac repolarizing potassium channels by potential class III agents." Thesis, 1994. http://hdl.handle.net/2429/5546.

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The aim of the study was to examine the use of a repolarizing calcium dependent potassium current K(Ca) in neurons to describe the actions of a group of novel compounds with potential Class ifi actions on cardiac cells. This was accomplished by determination of the correlation between potency of the agents to block single channel K(Ca) and potency to prolong effective refractory period (ERP) in heart. If a positive correlation could be established then elucidation of mechanisms of drug actions on single channel K(Ca) could have utility in the description of drug actions on repolarizing

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18

Guan, Wendy. "Domain II (S5-P) region in Lymnaea T-type calcium channels and its role in determining biophysical properties, ion selectivity and drug sensitivity." Thesis, 2014. http://hdl.handle.net/10012/8507.

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Invertebrate T-type calcium channels cloned from the great pond snail, Lymnaea Stagnalis (LCav3) possess highly sodium permeant ion channel currents by means of alternative splicing of exon 12. Exon 12 is located on the extracellular turret and the descending helix between segments 5 and segments 6, upstream of the ion selectivity filter in Domain II. Highly-sodium permeant T-type channels are generated without altering the selectivity filter locus, the primary regulatory domain known to govern ion selectivity for calcium and sodium channels. Comparisons of exon 12 sequences between invert

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19

Mahmoud, Sherif. "Drug-disease interaction: effect of inflammation on the pharmacological response to calcium channel blockers." Phd thesis, 2010. http://hdl.handle.net/10048/1540.

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The present research is focused on the topic of inflammation-drug interaction. Inflammation complicates many human diseases and conditions ranging from obesity to cancer. Therefore, the study of the effect of inflammation on drug pharmacokinetics and pharmacodynamics is pivotal. First, we tested the hypothesis that controlling inflammation using valsartan can restore the previously reported altered verapamil pharmacokinetics and pharmacodynamics. Such an effect is expected due to the anti-inflammatory properties of angiotensin II inhibition. Inflammation resulted in L-type calcium channel targ

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20

"Modulation by extracellular ATP of L-type Calcium channel currents in guinea-pig single sinoatrial nodal cells." 1997. http://library.cuhk.edu.hk/record=b6073002.

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by Ai-Dong Qi.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1997.<br>Includes bibliographical references (p. 219-256).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.

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21

Pan, Hung-Fang, and 潘虹方. "Correlation Study between Calcium Channel Antagonists-Macrolides Drug Interaction with Hypotension, Shock and Acute Kidney Injury." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/44812119808367474872.

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碩士<br>高雄醫學大學<br>藥學系碩士在職專班<br>103<br>Background: Previous case reports revealed that concomitant therapy with calcium channel blockers and macrolides resulted in hypotension. In 2012, the U.S. FDA issued a warning to remind physicians that the combination of clarithromycin and calcium channel blockers may cause severe hypotension. Drug-drug interactions not only affect the effectiveness, but also cause adverse effects, especially in cardiovascular drugs. Because a lot of cardiovascular drugs are metabolized by cytochrome P450 enzyme systems, simultaneous use with CYP 3A4 inhibitors or inducers

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22

Wang, Xueping. "Properties of drug blockade of a large conductance calcium-activated potassium channel in cultured rat hippocampal neurons." Thesis, 1992. http://hdl.handle.net/2429/3226.

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The objective of these experiments was to investigate the actions of a number of novel putative class III antiarrhythmic agents on the large conductance calcium-activated potassium channel (BK ) in cultured hippocampal neurons. The experiments were carried out in three steps. In the first set of experiments (BK)ca channel, isolated from cultured rat hippocampal CA1 neuronal somatic membrane, was first identified and its physiological and pharmacological properties were characterized at a single channel level. This (BKca ) channel had an average single channel conductance of 80 pS with p

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23

"The role of calcium ions in tumor necrosis factor-α-induced proliferation in C6 glioma cells". 2000. http://library.cuhk.edu.hk/record=b5895852.

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Kar Wing To.<br>Thesis submitted in: December 1999.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 200-223).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.i<br>List of Abbreviations --- p.ii<br>Abstract --- p.v<br>撮要 --- p.viii<br>List of Tables --- p.x<br>List of Figures --- p.xi<br>Contents --- p.xv<br>Chapter CHAPTER 1 --- INTRODUCTION<br>Chapter 1.1 --- The General Characteristics of Glial Cells --- p.1<br>Chapter 1.1.1 --- Astrocytes --- p.1<br>Chapter 1.1.2 --- Oligodendrocytes --- p.5<br>Chapter 1.1.3

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24

Longpré-Lauzon, Ariane. "Étude moléculaire des mécanismes d’action de potentiateurs du canal CFTR sur le canal KCa3.1." Thèse, 2009. http://hdl.handle.net/1866/4054.

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Анотація:

Les cellules épithéliales des voies aériennes respiratoires sécrètent du Cl- via le canal CFTR. La fibrose kystique est une maladie génétique fatale causée par des mutations de ce canal. La mutation la plus fréquente en Amérique du Nord, ∆F508, met en péril la maturation de la protéine et affecte les mécanismes d’activation du canal. Au cours des dernières années, plusieurs molécules ont été identifiées par criblage à haut débit qui peuvent rétablir l’activation de protéines CFTR mutées. Ces molécules sont nommées potentiateurs. Les canaux K+ basolatéraux, dont KCa3.1, jouent un rôle bien docu

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25

Krishnan, Harish Ravikumar 1975. "Molecular and genetic mechanisms of ethanol tolerance in the fruit fly." Thesis, 2007. http://hdl.handle.net/2152/3727.

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