Добірка наукової літератури з теми "C-terminal loop"
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Статті в журналах з теми "C-terminal loop"
MONLEÓN, Daniel, Vicent ESTEVE, Helena KOVACS, Juan J. CALVETE, and Bernardo CELDA. "Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMR." Biochemical Journal 387, no. 1 (March 22, 2005): 57–66. http://dx.doi.org/10.1042/bj20041343.
Повний текст джерелаHarouaka, Djamila, and Gail W. Wertz. "Mutations in the C-Terminal Loop of the Nucleocapsid Protein Affect Vesicular Stomatitis Virus RNA Replication and Transcription Differentially." Journal of Virology 83, no. 22 (September 2, 2009): 11429–39. http://dx.doi.org/10.1128/jvi.00813-09.
Повний текст джерелаBurkhart, Michael D., Paul D'Agostino, Samuel C. Kayman, and Abraham Pinter. "Involvement of the C-Terminal Disulfide-Bonded Loop of Murine Leukemia Virus SU Protein in a Postbinding Step Critical for Viral Entry." Journal of Virology 79, no. 12 (June 15, 2005): 7868–76. http://dx.doi.org/10.1128/jvi.79.12.7868-7876.2005.
Повний текст джерелаQiao, Renping, Florian Weissmann, Masaya Yamaguchi, Nicholas G. Brown, Ryan VanderLinden, Richard Imre, Marc A. Jarvis, et al. "Mechanism of APC/CCDC20 activation by mitotic phosphorylation." Proceedings of the National Academy of Sciences 113, no. 19 (April 25, 2016): E2570—E2578. http://dx.doi.org/10.1073/pnas.1604929113.
Повний текст джерелаTakemoto, D. J., L. J. Takemoto, J. Hansen, and D. Morrison. "Regulation of retinal transducin by C-terminal peptides of rhodopsin." Biochemical Journal 232, no. 3 (December 15, 1985): 669–72. http://dx.doi.org/10.1042/bj2320669.
Повний текст джерелаRen, Chunguang, Satoshi Nagao, Masaru Yamanaka, Hirofumi Komori, Yasuhito Shomura, Yoshiki Higuchi, and Shun Hirota. "Oligomerization enhancement and two domain swapping mode detection for thermostable cytochrome c552via the elongation of the major hinge loop." Molecular BioSystems 11, no. 12 (2015): 3218–21. http://dx.doi.org/10.1039/c5mb00545k.
Повний текст джерелаBury, Loredana, Emanuela Falcinelli, Haripriya Kuchi Bhotla, Anna Maria Mezzasoma, Giuseppe Guglielmini, Alexander Tischer, Laurie Moon-Tasson, Matthew Auton та Paolo Gresele. "A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD". Blood Advances 6, № 7 (1 квітня 2022): 2236–46. http://dx.doi.org/10.1182/bloodadvances.2021005463.
Повний текст джерелаUesugi, Y., J. Arima, M. Iwabuchi, and T. Hatanaka. "C-terminal loop of Streptomyces phospholipase D has multiple functional roles." Protein Science 16, no. 2 (December 22, 2006): 197–207. http://dx.doi.org/10.1110/ps.062537907.
Повний текст джерелаYano, Yoshiaki, Takuya Shimbo, Yukihiko Sugimoto та Katsumi Matsuzaki. "Intracellular third loop–C-terminal tail interaction in prostaglandin EP3β receptor". Biochemical and Biophysical Research Communications 371, № 4 (липень 2008): 846–49. http://dx.doi.org/10.1016/j.bbrc.2008.04.180.
Повний текст джерелаGoch, G., H. Kozłowska, A. Wójtowicz, and A. Bierzyński. "A comparative CD and fluorescence study of a series of model calcium-binding peptides." Acta Biochimica Polonica 46, no. 3 (September 30, 1999): 673–77. http://dx.doi.org/10.18388/abp.1999_4139.
Повний текст джерелаДисертації з теми "C-terminal loop"
Guo, Xiangxue. "Biochemical and Bioinformatics Analysis of CVAB C-Terminal Domain." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/3.
Повний текст джерелаReincke, Momsen [Verfasser]. "Inactivation and anion selectivity of volume-regulated anion channels depend on C-terminal residues of the first extracellular loop / Momsen Reincke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140486772/34.
Повний текст джерелаLin, Po-Yu, and 林柏宇. "Role of the SWI5 C-terminal loop in SWI5-SFR1c complex interaction with RAD51." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/95275546855885361965.
Повний текст джерела國立清華大學
生物資訊與結構生物研究所
104
SWI5-SFR1 protein complex (S5S1) has been proven as an accessory factor of homologous recombination repair, which can restore the DNA double strands break (DSB). When DNA double strands break (DSB) happen, RAD51 recombinases (RAD51) as a key protein form a presynaptic filament via binding to a single-stranded DNA. Then, ATP would bind to RAD51 to stabilize the RAD51-DNA complex and induce single-stranded DNA exchange. Due to the hydrolytic activity of RAD51, ATP would be hydrolyzed to ADP and the activity of RAD51-DNA complex will decrease, and S5S1 can promote the ADP releasing rate by interaction between RAD51. Recently, two active sites, F83 and L85, on the C-terminus of SWI5 (S5) have been reported to participate in the interaction between S5S1 and RAD51. In order to investigate their interaction, we use molecular modeling with the template “S5S1c from yeast (which has a known crystal structure, PDB code: 3VIQ)” to construct the model, we found that S5F83 and S5L85 are located in the hydrophobic core in the ending of S5 and faced inside the core. Hence, we speculate the two positions would expose and attach to RAD51 when the bundle structure on the S5 C-terminal alpha-helix was separated. To validate our hypothesis, first, we fix the C-terminal loop by creating the disulfide bond S5D89C-S1C53 on the complex. In addition, to prevent the other disulfide bond take place in the molecular, we also replaced the S1C59 to Ser. Next, we compared the secondary and tertiary structure by circular dichroism (CD) and small-angle X-ray scattering (SAXS). CD analysis showed that both S5S1c and S5D89CS1cC59S presented mainly alpha-helical structure, and their secondary structure compositions are similar by analyzed on the DichroWEB website. For SAXS experiment, we determined the structure characteristic of S5S1c and mutant, and constructed the ab initio model of them. The results showed no huge difference between S5S1c and mutant. Finally, the binding ability was determined by pull-down assay. We compared S5S1c, loop-fixed and unfixed S5D89CS1cC59S (without and with 2-ME treatment) The results showed that, compare to S5S1c, loop-fixed S5D89CS1cC59S cannot interact to RAD51, and it restored partially binding ability when freed the loop which indicate S5F83 and S5L85 could expose and bind to RAD51. In conclusion, we speculate the opening of S5 C-terminal loop is essential when S5S1c interact to RAD51. Our study provide information regarding to S5S1c binding to RAD51.
Hsu, Po-Hung, and 徐鉑泓. "Use Proximity-dependent biotinylation to identify C-terminal interacting proteins of mouse Cryptochrome 1 and to characterize their roles in the regulation of transcription-translation feedback loop of circadian clock." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5107005%22.&searchmode=basic.
Повний текст джерела國立中興大學
生物化學研究所
107
CRY is an important transcriptional regulator in the transcription-translation feedback loop of circadian rhythm. In mammalian cells, CRY transcription is activated by the CLOCK::BMAL1 transcription factor, and the production protein CRY can alone or form a heterodimer with another protein PER to repress the transcriptional activty of the circadian rhythm core proteins CLOCK and BMAL1 to achieve the feedback mechanism. CRY is one of a photolyase/cryptochrome family protein. The main difference from other member proteins is the sequence and length of the C-terminus. The major different from CRY1 and CRY2 in mouse and human is also the sequence at the C-terminus. It is known that the deletion of the C-terminal sequence does not affect the ability of CRY to repress CLOCK::BMAL1 complex, but its research is very limited. We hope to utilize the identification C-terminal interaction proteins to explore their effects on CRY1. The Biotin Labeling System (BioID) uses engineered biotin ligase to activate biotin to label surrounding proteins. The advantage is that the affinity of biotin and avidin enables the interacting proteins to be purified under the stronger conditions. In HEK293T cells, we expressed this biotin ligase at the C-terminus of CRY1 and Confirm the biotin ligase activity of the fusion protein. Then using the Dual-Luciferase Assay to confirm the CRY1 maintained the activity of repressing CLOCK::BMAL1 after BioID binding to C-terminus. And then using this fusion protein to express in the CPN_KO cells which deficient in CRY, PER and NR1D genes to rule out possible indirect affects. By using the detection of biotin-labeled proteins and qPCR to analysis the CLOCK: BMAL downstream gene Dbp expression to confirmed that the mark of the intracellular fusion protein and the activity of the transcriptional repressor still exist. At present, it is possible to label peripheral proteins near to CRY1 using BioID method by cell nuclear fraction treatment, and to distinguish many different kinds and sizes of proteins with a certain binding ability. And then, this protein will be further analyzed and purified as a target, and analyzed by mass spectrometry to study the interaction of its protein with CRY1 and its identity.
Wang, Chih-Chieh, and 王志傑. "NMR Study of Streptopain: The role of the catalytic and C-terminal Loops in its Inhibitor Binding and Protease Activity." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/46708686670521161731.
Повний текст джерела國立成功大學
生物化學研究所
94
Streptopain (streptococcal pyrogenic exotoxin B; SPE B) is an extracellular cysteine protease expressed by the pathogenic bacterium Streptococcus pyogenes. SPE B is initially expressed as a 42-kDa zymogen and subsequently converted to a 28-kDa active protease by autocatalysis or proteolysis. Many reports have shown that SPE B is an important virulence factor in streptococcal infection such as the dissemination, colonalization, invasion of bacteria, and inhibition of wound healing. To understand why SPE B has broad substrate specificity and to design the drugs for SPE B, we used NMR spectroscopy to determine the 3D structure and dynamics of the SPE B/inhibitor complex. Comparisons of NMR chemical shift differences between the SPE B/inhibitor complexes and the C47S mutant showed that six regions, including Y15-G18, T45-A51, S135-S141, G188-F197, W212-W214, and A231-A246, were involved in the binding of inhibitors to SPE B. The result suggests that the A231-A246 loop, which is unobserved in the crystal structure, may play important roles in substrate binding and recognition. Dynamics analysis of the SPE B/E-64, SPE B/E-64c, and SPE B/IAA complexes showed that the catalytic (G188-F197) and C-terminal (A231-G240) loops were the most flexible regions with motions on the ms/ms and ps/ns timescales. In contrast to the complexes with inhibitors containing carboxylic acid moiety, these loops of the C47S mutant and the SPE B/IAAm complex were less flexible. 3D structures of C47S mutant and SPE B/E-64 complex were determined by NMR spectroscopy. The distances between C-terminal and the catalytic loops of the C47S mutant and the SPE B/E-64 complex were 5.94 and 11.62 Å, respectively. This is consistent with NOE analysis that interactions between residues in H195 and A231, and in V192 and A238 were observed in the C47S mutant. Our mutagenesis study also showed that mutations on V189, the residue of the catalytic loop, and on G239, the residue of the C-terminal loop, caused an 11- to 61-fold decrease in activity, suggesting that they were important for the substrate binding. In this study, we found that not only the catalytic loop but also the C-terminal loop play and an important role in the substrate binding and enzyme catalysis of SPE B. We also found that the S135-S141 and W212-W214 loops, the conserved regions in the papain superfamily, have conformational exchange with high Rex values. Based on 15N/13C-edited and -filtered experiments, the NOE interactions indicated that G136 of the S135-S141 loop interacts with the inhibitor, E-64. The conformation of E-64 will be docked into 3D structure of SPE B with the observed intermolecular NOEs. These finding indicates that the C-terminal and the catalytic loops of SPE B play an important role in its substrate binding, and the results will facilitate rational drug design of SPE B.
Baalmann, Elisabeth. "Physiologische und strukturelle Untersuchungen zur Redoxmodulation, Aggregation/Dissoziation und Coenzymspezifität der NAD(P)(H)-Glycerinaldehyd-3-Phosphat Dehydrogenase." Doctoral thesis, 2004. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2004070814.
Повний текст джерелаЧастини книг з теми "C-terminal loop"
Inglis, Adam S., John F. K. Wilshire, Franca Casagranda, and Robert L. Laslett. "C-terminal Sequencing: A New Look at the Schlack-Kumpf Thiocyanate Degradation Procedure." In Methods in Protein Sequence Analysis, 137–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73834-0_18.
Повний текст джерелаOpella, S. J., and L. E. Chirlian. "A Solid-State NMR Approach to Structure Determination of Membrane-Associated Peptides and Proteins." In Biological NMR Spectroscopy. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195094688.003.0017.
Повний текст джерелаDrijfhout, Jan W., and Peter Hoogerhout. "Methods of preparing peptide—carrier conjugates." In Fmoc Solid Phase Peptide Synthesis. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637256.003.0014.
Повний текст джерелаТези доповідей конференцій з теми "C-terminal loop"
Hijikata-Okunomiya, A., S. Okamoto, R. Kikumoto, and Y. Tamao. "STEREOGEOMETRY OP THE ACTIVE SITES OF SERINE ENZYMES GATHERED FROM SYNTHETIC THROMBIN-INHIBITORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644606.
Повний текст джерелаpolyphemus, Limulus, T. Muta, T. Miyata, F. Tokunaga, T. Nakamura, and S. Iwanaga. "PRIMARY STRUCTURE OF ANTI-LIPOPOLYSACCHARIDE FACTOR ISOLATED FROM AMERICAN HORSESHOE CRAB." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644608.
Повний текст джерелаVerhagen, Joris, Etienne Heymans, Darko Gjorgjievski, Arjan Voogt, and Frederik Van Nuffel. "Eemshaven LNG - Repurposing an FSRU Built for Tropical Conditions to Operate in the North Sea." In Offshore Technology Conference. OTC, 2023. http://dx.doi.org/10.4043/32586-ms.
Повний текст джерелаDahiback, Bjorn, Ake Lundwall, Andreas Hillarp, Johan Malm, and Johan Stenflo. "STRUCTURE AND FUNCTION OF VITAMIN K-DEPENDENT PROTEIN S, a cofactor to activated protein C which also interacts with the complement protein C4b-binding protein." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642960.
Повний текст джерелаSoares, Luigi, and Fernando Magno Quintão Pereira. "Memory-Safe Elimination of Side Channels." In Concurso de Teses e Dissertações. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/ctd.2023.229445.
Повний текст джерелаSoukup, Todd J., and Vincent P. Heuring. "Implementation of a Fiber Optic Delay Line Memory." In Optical Computing. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/optcomp.1991.me14.
Повний текст джерелаЗвіти організацій з теми "C-terminal loop"
Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, January 2008. http://dx.doi.org/10.32747/2008.7695862.bard.
Повний текст джерела