Дисертації з теми "C–H Bond - Maleimides"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "C–H Bond - Maleimides".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Torkelson, Jeffrey Robert. "C-H bond activation and C-C bond formation at adjacent metals." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ34848.pdf.
Повний текст джерелаGuo, Xiangyu. "Ruthenium-catalyzed C-C bond formation via functional-group directed C-H bond activation." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110570.
Повний текст джерелаRésuméRuthenium-Catalyzed C-C Bond Formation via Functional-Group Directed C-H Bond ActivationXiangyu GuoSuperviseur: Prof. Chao-Jun LiUniversité McGillCette thèse est le résultat de la recherche sur la formation de liaisons carbone-carbone (C-C), catalysé par le ruthénium. La première partie de cette thèse expose les résultats sur la formation de liaison carbone-carbone (C-C) par la réaction de couplage oxydant par déshydrogénation. La synthèse de composés biaryl par l'utilisation d'un catalyseur de ruthénium a permis la dimérisation des dérivés de la 2-phénylpyridine en présence de chlorure de fer (III) comme oxydant terminal. En outre, l'oxydative cross-coupling entre arènes et cycloalcanes, a montrer une notable, para-sélectivité. La seconde partie de cette thèse, décrit les résultats obtenue sur la réaction d'oléfination decarbonylative entre un aldéhyde et un alcyne vrai, catalyser par le ruthénium. En partant d'aldéhydes aromatiques ou aliphatiques et par l'utilisation de deux systèmes catalytiques, la synthèse chemioselective de double liaison C=C conjuguée ou isolée ont pu être réalisé. Cette réaction fournit ainsi, une intéressante alternative à la synthèse de doubles liaisons C=C par la directe addition de liaison C-H sur une triple liaison.
Laren, Martijn Wouter van. "Palladium-catalyzed C-H and C-N bond formation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75422.
Повний текст джерелаVastine, Benjamin Alan. "Understanding mechanisms for C-H bond activation." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2679.
Повний текст джерелаWiley, Jack Scott. "C-H bond activation in iridium complexes /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8510.
Повний текст джерелаTruscott, Fiona Rosemary. "Transition metal catalysed C-C bond formation via C-H functionalisation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6a1ef296-8d63-470d-96bd-3e01a887c81f.
Повний текст джерелаCatino, Arthur John. "Oxidative C-H and C-C bond functionalization catalyzed by dirhodium caprolactamate." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/4188.
Повний текст джерелаThesis research directed by: Chemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Gao, Longhui. "C-H bond activation catalyzed by Ruthenium nanoparticles." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS348/document.
Повний текст джерелаDeuterated and tritiated compounds are widely used in numerous applications in chemistry, biology and material science. In the drug discovery and development process, ADME studies require quick access to labelled molecules, otherwise the drug development costs and timeline are significantly impacted. The rapid development of metabolomics has also increased the need for isotopically labelled compounds. In particular, deuterated molecules are used as internal standards for quantitative LC-MS/MS analysis of metabolites in biological fluids and tissues. In this context, a general method allowing the deuterium and tritium labelling of bioactive thioethers using a HIE reaction is described in the first chapter. From a fundamental point of view, this transformation is the first example of (Csp³)-H activation directed by a sulfur atom. In terms of application, this new reaction has been proved to be useful for the preparation of deuterated LC-MS/MS reference materials and tritiated pharmaceuticals owning high specific activity.In the second chapter of this manuscript, the development of a method allowing the cross-dehydrogenative homocoupling of 2-arylpyridines catalyzed by Ru/C is developed. Various substrates with different substituents were efficiently coupled to give the desired dimers in good yield. In terms of application, a series of pyridine-boron complexes derived from the phenyl pyridine dimers were also synthesized and their photophysical properties were studied.In the third chapter, a regioselective palladium catalyzed intramolecular arylation reaction allowing the synthesis of pyridine containing polycyclic compounds is described
Ebe, Yusuke. "Iridium-Catalyzed Carbon-Carbon Bond Formation Reactions via C-H Bond Activation." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225417.
Повний текст джерелаLocati, Abel Jean Serge. "Computational study of c-h bond cleavage and c-c bond formation processes catalyzed by transition metal complexes." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/79120.
Повний текст джерелаThe first part of the thesis is mainly devoted to the mechanism of a C-H activation reaction by a niobium complex. The mechanism of C-H bond activation of benzene by the TpMe2NbCH3-(c-C3H5)-(MeCCMe) complex was rationalized. The key intermediate is an unusual 2-cyclopropene complex. We rationalized the selectivities obtained for the activation of several alkylaromatics by the 2-cyclopropene niobium complex. The intriguing role of the alkyne ligand of the same complex, and its possible role in the migration processes, was investigated. In the second part of the thesis, we focused on the silicon based cross-coupling. The results suggest than the transmetalation is easier after phosphine dissociation, and in presence of the bromide ligand on the palladium. The beneficial effect of dibenzylideneacetone on the coupling was clarified.
Ho, Kelvin. "Rapid increase of molecular complexity through C–H and C–C bond activation." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2006222/.
Повний текст джерелаRousseaux, Sophie. "Palladium-Catalyzed C(sp2)-C(sp3) Bond Formation." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23058.
Повний текст джерелаBahgat, Sofi-Rosamelia. "Beta-diketiminato copper complexes in C-H bond amination." Connect to Electronic Thesis (CONTENTdm), 2010. http://worldcat.org/oclc/646165084/viewonline.
Повний текст джерелаWang, Lianhui. "Carboxylate-Assisted Ruthenium-Catalyzed Direct C-H Bond Functionalizations." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5E47-2.
Повний текст джерелаCorreia, Camille. "Oxidative C-C bond formation via metal-catalyzed coupling of two C-H bonds." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114441.
Повний текст джерелаCette thèse décrit la formation de nouvelles liaisons C-C par activation oxydative directe de deux liaisons C-H grâce à l'utilisation de métaux de transition comme catalyseurs. La première partie présentera trois différentes réactions de Cross-Dehydrogenative-Coupling (CDC) oxydantes. Dans un premier temps, sera présentée dans le chapitre 2, la réaction d'alkylation de liens C-H benzylique par 1,3-dicarbonyles et cétones. Ce system a démontré son efficacité sur une large variété de substrats contenant des liaisons C-H enolysable. De plus il a été rendu possible, grâce à l'utilisation d'un co-catalyseur organique, le N-Hydroxyphthalimide (NHPI), d'utiliser l'oxygène moléculaire comme oxydant terminal. Dans un second temps, nous étudierons l'utilisation du 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) comme médiateur pour l'alkynylation de liaisons sp3 C-H. Une nouvelle CDC réaction catalysée par le triflate de cuivre (I) sera présentée dans le chapitre 3, entre un alcyne et une liaison C-H benzylique. Le chapitre 4 présentera le développement de cette réaction à l'alcynation d'éthers benzyliques en présence d'une quantité catalytique de triflate d'argent (I). Ces deux procédures sont seulement applicables pour les alcynes vrais aromatiques. Finalement, le chapitre 6 portera sur la réaction de Minisci catalysée par le palladium. Le peroxyde radical α-hydroxyalkyl généré lors de la réaction est capable de réagir avec les azines. La quantité stœchiométrique d'acide nécessaire lors de la traditionnelle réaction de Minisci, a été remplacée par une quantité catalytique de dichloro palladium.
Poater, Teixidor Albert. "Isomerism and C-H, C-C, O-O, C-O bond activation studies by transition metals." Doctoral thesis, Universitat de Girona, 2006. http://hdl.handle.net/10803/7939.
Повний текст джерелаThis thesis shows that the cooperation between experimental and theoretical groups gives as a result the achievement of aims impossible working independently. From DFT calculations inorganic and organometallic problems related to great biological and industrial processes can be explained. This thesis is especially focused on the study of mononuclear and binuclear copper complexes, where a C-H, C-C, and O-O bond activation takes place. The study of octahedral ruthenium complexes has allowed carrying out isomeric studies and the rationalization of spectroscopic properties. Furthermore, other little studies related to copper clusters, the Pawson-Khand reaction, Pt-Pt bond interaction in trimer platinum complexes, and isomerism of Ni and Pt complexes.
Holthausen, Michael H., Tayseer Mahdi, Christoph Schlepphorst, Lindsay J. Hounjet, Jan J. Weigand, and Douglas W. Stephan. "Frustrated Lewis pair-mediated C–O or C–H bond activation of ethers." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A35977.
Повний текст джерелаDuin, Marcel Adrianus. "Nucleophilic and electrophilic platinum compounds for C-H bond activation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75218.
Повний текст джерелаDiers, Emelyne. "Ruthenium-Catalyzed Synthesis of Biaryls through C–H Bond Functionalizations." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BC4E-F.
Повний текст джерелаBlack, Stephen Ian. "Synthetic and mechanistic studies related to C-H bond activation." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/46966.
Повний текст джерелаLi, Bin. "Ruthenium(II) catalyzed C-H bond functionalization and hydrosilylation reactions." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1S114.
Повний текст джерелаIn this research doctoral thesis, we have shown that imines, 2-phenylpyridine, 2-phenyloxazoline, phenylpyrazole, benzo[h]quinoline led to cyclometallated ruthenium(II) complexes from [RuCl2(p-cymene)]2 and KOAc via sp2 C-H bond activation. [RuCl2(p-cymene)]2 /KOAc/PPh3 is an efficient catalytic system for diarylation of imines and 2-phenyloxazolines in water, which gave higher activity than in organic solvents. Bulky amines were then synthesized through sequential catalytic C-H arylation and hydrosilylation of imines using [RuCl2(p-cymene)]2 catalyst. Challenging selective mono arylation of 2-pyridyl arylketones, leading to six-membered ruthenacycle intermediate, difficult to perform, was achieved with in situ generated Ru(O2CC6H4CF3)2(p-cymene) catalyst. The direct dehydrogenative oxidative alkenylation of aryloxazolines with styrenes and acrylates was catalyzed by [RuCl2(p-cymene)]2/BNPAH (1,1′-binaphthyl-2,2′- diylhydrogenophosphate) catalytic system in the presence of Cu(OAc)2.H2O as an oxidant in air. Tandem catalytic oxidation of 2-pyridylmethanols and selective sp3 C-H (mono or di) α-alkylation of 2-pyridyl ketones with functional alkenes was performed by using [RuCl2(p-cymene)]2 complex in the presence of Cu(OAc)2.H2O in DCE or toluene. In the second part, it is shown that, [RuCl2(p-cymene)]2 is a very efficient catalyst for the hydrosilylation of imines and primary amides. A wide range of aldimines and ketimines were successfully reduced to corresponding amines in high chemoselectivity by using PMHS as greener silane in ethanol at RT. Moreover, challengingly, primary amides could be selectively converted by hydrosilylation to the secondary amines under solvent free conditions
Grupe, Sabine [Verfasser]. "The Iron App: Reductive Iron-Catalyzed C-H and C-C Bond Formations / Sabine Grupe." München : Verlag Dr. Hut, 2013. http://d-nb.info/1047035731/34.
Повний текст джерелаBarday, Manuel. "Rapid access to heterocycles using transition-metal catalysed C-H and C-C bond activation." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3029020/.
Повний текст джерелаCrépin, Damien. "Rhodium-catalysed C-H and C-C bond activation towards the formation of medium-sized rings." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569765.
Повний текст джерелаGallardo, Donaire Juan. "Synthesis of phthalides and benzolactones via catalytic C-H functionalization/C-O bond-forming." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/276960.
Повний текст джерелаThe main objective of this Thesis has been the activation of inert C-H bonds catalytically for the construction of C-O bonds. The fist project developed consisted on the activation of C(sp3)-H bonds for the direct synthesis of phthalides catalyzed by Pd, employing simple benzoic acids as starting materials. Continuing in the same research line, the second project described deals with the utilization of cheaper and easy to handle Cu salts as catalyst for the functionalization of C(sp2)-H bonds towards the formation of C-O bonds for the synthesis of benzolactones. Finally, the last project discovered handles a metal-free C-H functionalization approach for the synthesis of benzolactones by using simple iodoarenes as catalyst, thus
Coxon, Thomas. "Investigating rhodium-catalysed hydroacylation and carbon-carbon bond activation." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:26111304-1563-4c18-956e-67636b87983a.
Повний текст джерелаFallon, Brendan. "Cobalt-catalyzed bond activation : C-H functionalization, hydrosilylation and coupling reactions." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066411/document.
Повний текст джерелаThis thesis has focused on the use of well-defined low-valent cobalt complexes of the family RCo(PMe3)4 for a variety of bond activation (C–H, Si–H, C–X). We aimed to develop a catalytic system that could compete with the previously reported bimetallic systems of Yoshikai and expensive rhodium catalysis. To this end, we successful demonstrated that Co(PMe3)4 and HCo(PMe3)4 are efficient catalysts for the hydroarylation of a broad variety of alkynes and alkenes. In addition, we carried out extensive mechanistic investigations using deuterium labelling experiments and theoretical studies namely DFT. The main finding of these studies was that the C–H bond activation proceeded via a ligand-to-ligand hydrogen transfer mechanism. Following on from this study we then showed that it was possible to carry out the regio- and stereoselective hydrosilylation of internal alkynes with a broad variety of hydrosilanes. During this study we successfully isolated an interesting cobalt(III) intermediate which we believe plays a crucial role in the reaction mechanism. Finally, we report on the ability of these catalysts to efficiently catalyze the homocoupling of benzyl halides in the presence of dimethylzinc. Initial mechanistic investigations suggest that the reaction takes via two single electron transfers and that dimethylzinc act to regenerate the catalyst
Pearson, Stephen. "High oxidation state carbene complexes for C-H bond activation catalysis." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/7570.
Повний текст джерелаKossen, Hanno. "Exploration of Brønsted base catalysis for formal C–H bond activations." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23598.
Повний текст джерелаTeskey, Christopher. "Strategic use of transition metals for selective C-H bond functionalisation." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/strategic-use-of-transition-metals-for-selective-ch-bond-functionalisation(496828e4-75db-428e-afb5-0138d55c3258).html.
Повний текст джерелаToh, Qiao Yan. "Organocatalysis in total synthesis and C-H bond arylation of aldehydes." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648134.
Повний текст джерелаGu, Yiting. "C-H & C-O Functionalization by Silicon-Heteroatom Interelement Linkage." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668961.
Повний текст джерелаLa química sintética es casi inimaginable sin tres elementos principales del grupo, a saber, boro, silicio y estaño. Cuando se unen a un átomo de carbono de cualquier hibridación, estos grupos funcionales sirven como linchpins excepcionalmente versátiles en síntesis, transformándose selectivamente en una enorme variedad de enlaces C-C y C-X, por lo tanto, descubren nuevos métodos para forjar el valor agregado C-Si, Los bonos C-B y C-Sn siempre tienen una gran demanda. En línea con el interés de la investigación en el grupo de Martín de la activación de enlaces o moléculas inertes, esta tesis doctoral se centra en el desarrollo de nuevas técnicas para hacer uso del enlace de interelemento de silicio-heteroátomo para funcionalizar el enlace inerte C-O & C-H a través de catálisis de níquel o sistema sin transición de metal. Hemos desarrollado tres nuevos métodos para la funcionalización de enlaces inertes C-O y C-H mediante el uso de enlaces de interelemento basados en silicio. Todas las transformaciones anteriores muestran un excelente perfil de quimioselectividad en condiciones suaves. Se realizan estudios y debates mecanicistas preliminares para comprender cómo y por qué se produjeron estas reacciones. Las transformaciones realizadas contribuyen a la comprensión del uso más prolífico de enlaces químicos inertes a los compuestos de valor agregado de síntesis.
Synthetic chemistry is almost unimaginable without three main group elements, namely, boron, silicon, and tin. When attached to a carbon atom of any hybridization, these functional groups serve as exceptionally versatile linchpins in synthesis, selectively transforming into an enormous breadth of C-C and C-X bonds, thus, discover new methods to forge value added C-Si, C-B and C-Sn bonds are always in highly demand. In line with the research interest in Martín’s group of activating inert bonds or molecules, this doctoral thesis focuses on the development of novel techniques to make use of silicon-heteroatom interelement linkage to functionalize inert C-O & C-H bond via either nickel catalysis or transition metal free system. We have developed three new methods towards the functionalization of inert C-O & C-H bonds by using silicon-based interelement linkages. All the above transformations display excellent chemoselectivity profile under mild conditions. Preliminary mechanistic studies and discusses are carried out to understand how and why these reactions proceeded. The transformations realized contribute to the understanding of more prolific use of inert chemical bonds to the synthesis value added compounds. We believe these protocols would definitely contribute to a systematic utilization of silicon-heteroatom reagent in the arena of inert chemical bond functionalization.
Wang, Chang-Sheng. "Selective catalytic C(sp²)–H and C(sp³)–H bond functionalizations for the synthesis of phosphorus and nitrogen containing molecules." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1S106/document.
Повний текст джерелаIn the first chapter, we have developed an efficient approach for the fast modification of arylphosphine oxides using ruthenium(II)-catalyzed C–H bond functionalization with alkenes. Interestingly, we have found that the selectivity of the reaction, namely alkylation versus alkenylation, is depending on the reaction pH. The reduction of the phosphine oxide allows the formation of aryl phosphines bearing a flexible pendent carboxylate. In the second objective, a copper-catalyzed oxidative C(sp3)–H/N–H coupling of NH-heterocycles with affordable (cyclo)alkanes was developed. This protocol involved C(sp3)–N bond formation via a radical pathway generated by a homolytic cleavage of di-tert-butyl peroxide and trapping of the radical(s) by copper catalyst.In a third part, benzylic C(sp3)–H acyloxylation of 2-alkylpyridine, 2-alkylpyrazine and 2-alkylthiazole compounds was achieved using simple aldehydes via a copper-catalyzed tandem reaction, involving oxidative esterification followed by O-atom transfer. Finally, pyridin-2-ylmethyl tosylate derivatives are obtained in high yields from 2-alkylpyridine N-oxides via a [3,3]-sigmatropic rearrangement of the adduct between 2-alkylpridine N-oxides with benzenesolfonyl chlorides. Moreover, alkylnitrones also underwant [3,3]-sigmatropic rearrangement to give α-tosylated ketones after hydrolysis
Raghuvanshi, Keshav. "Ruthenium(II)-Catalyzed C-N, C-O and C-C Formations by C-H Activation." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://hdl.handle.net/11858/00-1735-0000-002B-7D4C-2.
Повний текст джерелаHofmann, Nora. "Carboxylate-Assisted Ruthenium-Catalyzed C-H Bond meta-Alkylations and Oxidative Annulations." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://hdl.handle.net/11858/00-1735-0000-0014-D4A4-1.
Повний текст джерелаZhao, Liang. "Functionalization of the C-H bond adjacent to a secondary nitrogen atom." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86795.
Повний текст джерелаA copper-mediated oxidative coupling between glycine derivatives (including short peptides) and nucleophiles (including malonates, aryl alkynes, arylboronic acids and indoles) were developed. Later, a chiral chlorosilane induced asymmetric indolation of imino amides was also studied. In addition, a study on the α-arylation of tetrahydroisoquinoline with iodobenzene was presented. The reaction was proposed to undergo via palladium catalyzed β-hydride elimination, imine insertion pathway.
This thesis also described a three-component coupling reaction of aldehyde, alkyne and alkyl hydroxylamine catalyzed by CuCl/bipy complex to synthesize β-lactam was presented.
In the end of the thesis, a collaboration work with the Department of Biochemistry on the study of thioxothiazolidinone derivatives as the cellular inhibitor of protein tyrosine phosphatase 1B was presented. The thioxothiazolidinone derivatives were synthesized and the bioactivities were studied.
Cette thèse a pour sujet le développement de nouvelles méthodes pour la fonctionnalisation directe de composés possédant des amines secondaires via l'oxydation de liaisons C-H.
Dans la première partie de cette thèse, un couplage oxydant au cuivre entre des dérivés de la glycine (incluant des peptides de petite taille) et des nucléophiles est présenté. L'indolisation asymétrique d'amides aminés induit par une silicone chlorée est également étudiée. Cette partie se termine par une étude de l'arylation-alpha de la tetrahydroisoquinoline avec de l'iodobenzène. Une voie mécanistique catalysée par le palladium, faisant intervenir une β-H élimination suivie d'une insertion d'imine est proposée. fr
Dans la deuxième partie de cette thèse, est présenté une réaction de couplage à trois composés entre aldéhydes, alcynes et hydroxylamines alkyles, catalysée par un complexe CuCl/bipy, pour la synthèse de β-lactames. fr
Dans la dernière partie de cette thèse, est présenté un travail en collaboration avec le département de biochimie sur l'étude de dérivés de thioxothiazolidinone comme inhibiteurs cellulaires de la protéine tyrosine phosphatase 1B. Ces dérivés de thioxothiazolidinone furent synthétisés et leurs activités biologiques furent étudiées. fr
Berg, Tieme Adriaan van den. "Iron catalyzed oxidation chemistry from C-H bond activation to DNA cleavage /." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/315029242.
Повний текст джерелаSong, Weifeng. "Cobalt- and Nickel-Catalyzed Functionalization of Unactivated C–Hal, C–O and C–H Bonds." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BC70-0.
Повний текст джерелаZhang, Zhuan. "Late Stage Modifications of Phosphines using Transition-Metal-Catalyzed C–H Bond Functionalization." Thesis, Rennes, Ecole nationale supérieure de chimie, 2020. http://www.theses.fr/2020ENCR0067.
Повний текст джерелаThe main objective of this PhD thesis deals with the preparation of polyfunctional phosphines by late-stage diversification of commercially available ligands. We have developed rhodium(I)-catalyzed ortho’- C–H bond alkylation of biarylphosphines. This new methodology provides a straightforward access to a large library of multifunctionalized phosphines. Some of these modified ligands outperformed commercially available phosphines in the Pd-catalyzed carboxylation of aryl bromides with carbon dioxide in the presence of a photoredox catalyst. To improve the diversity of biarylphosphines, we have also perfected the P(III)-directed C−H bond alkenylation of (dialkyl)- and (diaryl)biarylphosphines using internal alkynes. Chloride-free [Rh(OAc)(COD)]2 acts as a better catalyst than [RhCl(COD)]2. Conditions were developed to control the mono- and difunctionalization. One of these novel bisalkenylated (dialkyl)biarylphosphines was employed for the preparation of a palladium(II) complex, and some of these functionalized ligands outperformed their corresponding unfunctionalized phosphines in Pd-catalyzed amidation of sterically hindered aryl chlorides. Finally, we have also explored a novel protocol C–H bond alkylation of phosphines via 5- or 7- membered ring cyclometallated phosphineruthenium intermediates. These functionalized phosphines have potential to improve crosscoupling reactions of sterically hindered aryl (pseudo)halides
To, Wai-pong, and 杜偉邦. "Transition metal catalysed photo-induced oxidative C-H bond functionalization and water oxidation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193012.
Повний текст джерелаpublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Tanji, Yutaka. "Steric Effect of Carboxylate Ligands on Pd-Catalyzed C-H Bond Arylation Reactions." Kyoto University, 2020. http://hdl.handle.net/2433/253293.
Повний текст джерелаBheeter, Charles Beromeo. "Palladium-catalysed C-H bond activation for simpler access to ArSO₂R derivatives." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1S171.
Повний текст джерелаDuring this Ph.D. period, we were interested in the C-H bonds activation catalysed by palladium catalysts for the preparation of biaryls units bearing SO₂R group. Many biological compounds present a SO₂R function and thus we chose to activate this family of substrates. This method is considered as cost effective and environmentally attractive compared to other types of couplings such as Suzuki, Stille, or Negishi. First, we demonstrated that it is possible to apply C-H bond activation method for the direct arylation of thiophene derivatives bearing a SO₂R substituent. We then established palladium-catalysed system for the selective C2 arylation of N-tosylpyrrole derivatives. We found that N-tosylpyrrole is more reactive than free NH-pyrrole. We also studied the direct arylation of heteroarenes using bromobenzenes bearing SO₂R substituents either at C2 or C4 via palladium-catalysed C-H activation. This method provides a simpler access to substituted SO₂R derivatives. Finally we developed the first palladium-catalysed dehydrogenative sp³ C-H bond functionalization/activation of N-alkyl-benzenesulfonamides to produce N-alkenyl-benzenesulfonamides. The reaction proceeds with easily accessible ligand-free Pd(OAc)₂ catalyst for aryl bromides bearing electron-withdrawing groups or PdCl(C₃H₅)(dppb) catalyst for aryl bromides with electron-donating substituents. We found that the reaction tolerates a variety of substituents both on nitrogen and on the bromobenzene moiety
Zhao, Liqin. "Palladium-catalyzed direct arylation via sp² and sp³ C-H activation of hetero(aromatics) and hydrocarbons for C-C bond formation." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S038/document.
Повний текст джерелаDuring this thesis, we were interested in the sp² and sp³ C-H bond activation catalyzed by palladium catalysts for the preparation of (hetero)aryl-aryls and biaryls. This method is considered as cost effective and environmentally attractive compared to the classical couplings such as Suzuki, Heck, or Negishi. First we described the palladium-catalyzed direct C2-arylation of benzothiophene in the absence of phosphine ligand with high selectivity. We also demonstrated that it is possible to active both C2 and C5 C-H bonds for access to 2,5-diarylated compounds in one step, and also to non-symmetrically substituted 2,5-diarylpyrroles via sequential C2 arylation followed by C5 arylation. We also studied the reactivity of polychlorobenzenes via palladium-catalyzed C-H activation. We finally examined the palladium-catalysed selective sp² and sp³ C-H bond activation of guaiazulene. The selectivity depends on the solvent and base: sp² C2-arylation (KOAc in ethylbenzene), sp² C3-arylation (KOAc in DMAc) and sp³ C4-Me arylation (CsOAc/K₂CO₃ in DMAc). Through this method, a challenging sp³ C-H bond was activated
Fenner, Sabine [Verfasser], Lutz [Akademischer Betreuer] Ackermann, and Ulf [Akademischer Betreuer] Diederichsen. "Sustainable Strategies for Site-Selective C−VC Bond Formations through Direct C−H Bond Functionalizations / Sabine Fenner. Gutachter: Lutz Ackermann ; Ulf Diederichsen. Betreuer: Lutz Ackermann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1043767320/34.
Повний текст джерелаZhao, Qun. "Palladium-catalyzed directed introduction of α-CF3-vinyl and SCF3 groups by C-H bond functionalization". Thesis, Normandie, 2017. http://www.theses.fr/2017NORMIR15.
Повний текст джерелаRecent years have witnessed a great development of the organofluorine chemistry field. In particular, the introduction of emergent fluorinated moieties onto various scaffolds has attracted attention of the scientific community because of their special properties. Besides, transition metal-catalyzed directed C-H bond functionalization strategy has brought a revolution in the development of original synthetic methodologies, since it allows straightforward and more atom-economical processes. Thus, the design of new synthetic approaches for the introduction of fluorinated moieties by transition metal-catalyzed C-H bond functionalization pathway is particularly appealing. Therefore, in this Ph.D. thesis, we focused on the development of new methodologies for the direct introduction of fluorinated moieties onto arenes and olefins by transition metal catalyzed directed C(sp2)-H bond functionalization. In particular, we turned our attention to the 2-bromo-3,3,3-trifluoropropene (BTP), an inexpensive fluorinated reagent coming from industry waste, used as a potential halon replacement for fire suppression and as a fluorinated building block in organic synthesis (Chapter 1). The first part of this Ph.D. thesis was dedicated to the development of new methodologies for the direct introduction of a CF3- vinyl moiety onto arenes and olefins by a Pd-catalyzed directed C(sp2)-H bond functionalization with BTP. Then, this approach was extended to the functionalization of α,β-unsaturated esters, although a different reaction pathway is probably involved (Chapter 2). In the second part of this Ph.D. thesis, we developed a new methodology for the direct introduction of the SCF3 group onto arenes and olefins by Pd-catalyzed directed C(sp2)-H bond functionalization using the Munavalli reagent (Chapter 3)
Borràs, Noguera Carlota. "Sustainable and cost-effective development of chiral metal-catalysts for C-H and C-X bond forming reactions." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/664741.
Повний текст джерелаLa obtención de compuestos enantioméricamente puros se ha convertido una necesidad que ha conducido a un importante progreso en la catálisis asimétrica, principalmente usando compuestos organometalicos quirales. Entre las diferentes estrategias en la optimización de los catalizadores para conseguir elevadas selectividades y actividades, el diseño y la correcta selección de ligandos quirales, modificando sus propiedades es fundamental y la más utilizada. Que un ligando sea fácil de sintetizar a partir de compuestos de partida accesibles y que estos ligandos sean estables y fáciles de manipular, tienen un elevado interés en la industria. En este contexto, el principal objetivo de esta tesis es la síntesis de distintas familias de ligandos quirales, cumpliendo con los requisitos previamente mencionados, y su posterior aplicación en distintas reacciones asimétricas de alto interés industrial: hidrogenación de alquenos funcionalizados y no funcionalizados catalizados por Rh y Ir, hidrogenación de cetonas catalizada por Ir, reacciones de substitución alílica catalizada por Pd y reacciones de substitución propargílica catalizada por Cu. Se han sintetizado diferentes familias de ligandos Fosfito/fosfinito-tioéter/selenoéter, carbeno-tioéter, amino-fosfito/fosfinito/fosfina, y varias familias de ligandos tridentados.
The obtaining of enantiomerically pure compounds has become a need that led to an important progress in asymmetric catalysis, mainly using organometallic chiral compounds. Among different strategies to optimize catalysts in order to obtain high selectivities and activities, the design and the correct selection of chiral ligands, modifying their properties, is fundamental and the most used strategy. Ligands easy to synthesize from readily accessible starting material and stable and easy to manipulate ligands, have a high interest in the industry. In this context, the main objective of this thesis is the synthesis of different chiral ligand families, according to the previously mentioned requirements, and their application in different asymmetric reactions with high industrial interest: Rh- and Ir-catalyzed hydrogenation of functionalized and minimally functionalized olefins; Ir-catalyzed hydrogenation of simple ketones; Pd-catalyzed asymmetric substitution of allylic acetates and Cu-catalyzed propargylic substitution. There have been synthesized different phosphite/phosphinite-thioether/selenoether, carbene-thioether, amino-phosphite/phosphinite/phosphine and various tridentated ligand families.
Baslé, Olivier. "Oxidative generation of reactive iminium-intermediates: A powerful strategy for C-H bond functionalization." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86908.
Повний текст джерелаIn the first part of this thesis, a copper-catalyzed oxidative alkylation of sp3 C-H bond adjacent to a nitrogen atom is described. This environmentally respectful process used molecular oxygen as oxidant and water as solvent.
In the second part of the thesis, an aerobic sp3 C-H bond phosphonation reaction is presented. This process catalyzed by copper(I) bromide using dialkylphosphites as nucleophiles offered direct C-P bond formation via direct oxidative coupling of C-H and P-H bonds.
In the third part of the thesis, a copper-catalyzed sp3 C-H bond arylation with boronic acids in absence of directing group is described. The oxidative arylation reaction provided easy access to biologically active tetrahydroisoquinoline derivatives and can either use peroxide or molecular oxygen as oxidant.
In the last part of the thesis, the aerobic and electrochemical Cross-Dehydrogenative-Coupling in ionic liquids is presented. Ionic liquids have demonstrated high efficiency when applied as solvent and electrolyte solvent for the oxidative nitro-Mannich carbon-carbon bond formation.
Cette thèse est une investigation sur la génération et la réactivité de carbocations adjacents à un atome d'azote trisubstitué (iminium).
Dans la première partie de cette thèse, une alkylation d'une liaison sp3 C-H adjacente à un atome d'azote catalysée au cuivre est décrite. Ce procédé respectueux de l'environnement utilisa l'oxygène comme oxydant et l'eau comme solvant.
Dans la deuxième partie de cette thèse, une réaction aérobique de phosphonation de liaison sp3 C-H est présentée. Ce procédé catalysé par un sel de bromure de cuivre(I) et utilisant des bis-alkylphosphites comme nucléophiles permit la synthèse directe de liaisons C-P via le couplage oxydant de liaisons carbone-hydrogène et phosphore-hydrogène.
Dans la troisième partie de cette thèse, une réaction d'arylation de liaison sp3 C-H, catalysée par le cuivre, avec des acides boroniques en absence de groupement directeur est décrite. Cette réaction d'arylation, utilisant soit un peroxyde soit l'oxygène comme oxydant, donna des dérivés de la tétrahydroisoquinoline biologiquement actifs.
Dans la dernière partie de cette thèse, le couplage croisé déshydrogénant aérobique et électrochimique en liquides ioniques est présenté. Les liquides ioniques ont démontré une grande efficacité pour la formation de liaisons C-C (nitro-Mannich oxydante) lors de leurs utilisations comme solvant et solvant électrolyte.
Carreon-Macedo, Jose-Luis. "Computational studies of spin-forbidden organometallic chemistry : ligand binding and C-H bond activation." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432972.
Повний текст джерелаParveen, Riffat. "Computational Studies of C-H Bond Activation and Ethylene Polymerization Using Transition Metal Complexes." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1505131/.
Повний текст джерелаYuan, Kedong. "Palladium-catalyzed sp² C-H bond functionalization : construction of photoswitches and desulfitative cross-couplings." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S136/document.
Повний текст джерелаDuring this thesis, we were interested in the synthesis of organic photo-switches [DAE, di(hetero)arylethenes] via palladium catalyzed sp2 C-H bond activation of heteroaromatics. The previously established catalysts system for direct arylation, Pd(OAc)₂/KOAc/DMA, was found to be suitable for the new desired transformations. This method allows the straightforward access to a wide variety of useful photo-switchable molecules in a few steps. Moreover, during the course of further developments of C-H bond functionalization of heteroaromatics, we found that a phosphine free catalytic system, Pd(CH₃CN)₂Cl2/Li ₂CO₃/dioxane, promotes the coupling of thiophenes and arylsulfonyl chlorides to afford unexpected β-arylated products. This new catalytic system can also be utilized in conjugate addition reaction by using enones and arylsulfonyl chlorides as coupling partners. Finally, we describe PdCl2/CuBr co-catalyzed formation of 4-aryl-1,2,3,4-tetrahydroquinolines via cascade desulfitative Heck/sp² C-H activation sequence