Добірка наукової літератури з теми "Branched peptide"
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Статті в журналах з теми "Branched peptide"
Eggimann, Gabriela A., Emilyne Blattes, Stefanie Buschor, Rasomoy Biswas, Stephan M. Kammer, Tamis Darbre, and Jean-Louis Reymond. "Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells." Chem. Commun. 50, no. 55 (2014): 7254–57. http://dx.doi.org/10.1039/c4cc02780a.
Повний текст джерелаGudlur, Sushanth, Xiao Yao, Yasuaki Hiromasa, Takeo Iwamoto, and John M. Tomich. "Peptide Nanovesicles: Supramolecular Assembly of Branched Amphipathic Peptides." Biophysical Journal 100, no. 3 (February 2011): 388a. http://dx.doi.org/10.1016/j.bpj.2010.12.2304.
Повний текст джерелаYang, Dongsik, Hongjian He, and Bing Xu. "Enzyme-instructed morphological transition of the supramolecular assemblies of branched peptides." Beilstein Journal of Organic Chemistry 16 (November 4, 2020): 2709–18. http://dx.doi.org/10.3762/bjoc.16.221.
Повний текст джерелаSPETZLER, JANE C., and JAMES P. TAM. "Unprotected peptides as building blocks for branched peptides and peptide dendrimers." International Journal of Peptide and Protein Research 45, no. 1 (January 12, 2009): 78–85. http://dx.doi.org/10.1111/j.1399-3011.1995.tb01570.x.
Повний текст джерелаPlaué, S., S. Muller, and M. H. van Regenmortel. "A branched, synthetic octapeptide of ubiquitinated histone H2A as target of autoantibodies." Journal of Experimental Medicine 169, no. 5 (May 1, 1989): 1607–17. http://dx.doi.org/10.1084/jem.169.5.1607.
Повний текст джерелаWang, Jian-Xun, Yi-Xiao Zhang, Jiang-Lan Li, Xiao-Ding Xu, Ren-Xi Zhuo, and Xian-Zheng Zhang. "Branched peptide fibers self-assembled from gemini-like amphiphilic peptides." Soft Matter 8, no. 37 (2012): 9523. http://dx.doi.org/10.1039/c2sm26136g.
Повний текст джерелаGudlur, Sushanth, Pinakin Sukthankar, Jian Gao, L. Adriana Avila, Yasuaki Hiromasa, Jianhan Chen, Takeo Iwamoto, and John M. Tomich. "Peptide Nanovesicles Formed by the Self-Assembly of Branched Amphiphilic Peptides." PLoS ONE 7, no. 9 (September 18, 2012): e45374. http://dx.doi.org/10.1371/journal.pone.0045374.
Повний текст джерелаKersten, Roland D., and Jing-Ke Weng. "Gene-guided discovery and engineering of branched cyclic peptides in plants." Proceedings of the National Academy of Sciences 115, no. 46 (October 29, 2018): E10961—E10969. http://dx.doi.org/10.1073/pnas.1813993115.
Повний текст джерелаLe, Zhiping, Wei Huang, Xiaobo Tian, Pengqiu Yu, and Yubo Tang. "Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides." Synlett 28, no. 15 (June 29, 2017): 1966–70. http://dx.doi.org/10.1055/s-0036-1588870.
Повний текст джерелаPini, Alessandro, Ylenia Runci, Chiara Falciani, Barbara Lelli, Jlenia Brunetti, Silvia Pileri, Monica Fabbrini, et al. "Stable peptide inhibitors prevent binding of lethal and oedema factors to protective antigen and neutralize anthrax toxin in vivo." Biochemical Journal 395, no. 1 (March 15, 2006): 157–63. http://dx.doi.org/10.1042/bj20051747.
Повний текст джерелаДисертації з теми "Branched peptide"
Gudlur, Sushanth. "Peptide nanovesicles: supramolecular assembly of branched amphiphilic peptides." Diss., Kansas State University, 2012. http://hdl.handle.net/2097/13445.
Повний текст джерелаDepartment of Biochemistry
John M. Tomich
Peptide-based delivery systems show great potential as safer drug delivery vehicles. They overcome problems associated with lipid-based or viral delivery systems, vis-a-vis stability, specificity, inflammation, antigenicity, and tune-ability. We have designed and synthesized a set of 15 and 23-residue branched, amphiphilic peptides that mimic phosphoglycerides in molecular architecture. They undergo supramolecular self-assembly and form solvent-filled, bilayer delineated spheres with 50-150 nm diameters (confirmed by TEM and DLS). Whereas weak hydrophobic forces drive and sustain lipid bilayer assemblies, these structures are further stabilized by β-sheet hydrogen bonding and are stable at very low concentrations and even in the presence of SDS, urea and trypsin as confirmed by circular dichroism spectroscopy. Given sufficient time, they fuse together to form larger assemblies and trap compounds of different sizes within the enclosed space. They are prepared using a protocol that is similar to preparing lipid vesicles. We have shown that different concentrations of the fluorescent dye, 5(6)-Carboxyfluorescein can be encapsulated in these assemblies and delivered into human lens epithelial cells and MCF-7 cells grown on coverslips. Besides fluorescent dyes, we have delivered the plasmid (EGFP-N3, 4.7kb) into N/N 1003A lens epithelial cells and observed expression of EGFP (in the presence and absence of a selection media). In the case of large molecules like DNA, these assemblies act as nanoparticles and offer some protection to DNA against certain nucleases. Linear peptides that lacked a branching point and other branched peptides with their sequences randomized did not show any of the lipid-like properties exhibited by the branched peptides. The peptides can be chemically decorated with target specific sequences for use as DDS for targeted delivery.
Bryson, David Irby. "Targeting RNA Structures with Multivalent Branched Peptide Libraries." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77327.
Повний текст джерелаPh. D.
Zhang, Wenyu. "Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/56731.
Повний текст джерелаPh. D.
Mandarini, Elisabetta. "Decoding the role of HSPGs in tumor onset and progression through use of branched peptide probe." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1094789.
Повний текст джерелаCastiglia, Francesca. "The antimicrobial peptide SET-M33. Strategies to improve the manufacturing procedures and production of back-up molecules as novel antibiotics." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1142986.
Повний текст джерелаSukthankar, Pinakin Ramchandra. "Biophysical characterization of branched amphiphilic peptide capsules and their potential applications in radiotherapy." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18174.
Повний текст джерелаDepartment of Biochemistry and Molecular Biophysics
John M. Tomich
Branched Amphiphilic Peptide Capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble in water to form bilayer delimited poly-cationic capsules capable of trapping solutes. We examined the lipid-like properties of this system including assembly, fusion, solute encapsulation, and resizing by membrane extrusion as well as their capability to be maintained at a specific size by storage at 4˚C. These studies along with earlier work from the lab (Gudlur et al. (2012) PLOS ONE 7(9): e45374) demonstrated that the capsules, while sharing many properties with lipid vesicles, were much more robust. We next investigated the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs. We demonstrated that the BAPCs are readily taken up by epithelial cells in culture, escape or evade the endocytotic pathway, and accumulate in the peri-nuclear region where they persist without any apparent degradation. The stability and persistence of the capsules suggested they might be useful in delivering radionuclides. The BAPCs encapsulated alpha particle emitting radionuclides without any apparent leakage, were taken up by cells and were retained for extended periods of time. Their potential in this clinical application is being currently pursued. Lastly we studied the temperature dependence of capsule formation by examining the biophysical characteristics of temperature induced conformational changes in BAPCs and examined the structural parameters within the sequences that contribute to their remarkable stability. A region in the nine-residue sequence was identified as the critical element in this process. The ability to prepare stable uniform nano-scale capsules of desired sizes makes BAPCs potentially attractive as delivery vehicles for various solutes/drugs.
Wynn, Jessica Elaine. "Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82227.
Повний текст джерелаPh. D.
Martin, Julie. "Design and direct synthesis of peptide-branched polysiloxane. Towards new generation of hybrid biomaterials." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS093.
Повний текст джерелаThe purpose of this PhD work was the design and synthesis of new hybrid biomaterials based on a polysiloxane backbone. To do so, several biomolecules were silylated, in order to be incorporated in a multifunctional silicone backbone by a bottom-up strategy. Indeed, in contrast to post-grafting approaches, we set up the direct copolymerization of hybrid biomolecule macromonomers presenting a methyldihydroxysilyl moiety, with the dichlorodimethylsilane (DCDMS). Different types of biomolecules have been silylated: peptides, drugs and imaging probes, each of them affording specific properties to the final bioorganic silicone material. Three main applications are described: (i) the design and synthesis of bioactive PDMS cross-linked materials, (ii) silicone-based nanoparticules (NPs) and (iii) silicone-based polyplexes. PDMS materials with biological properties, either antimicrobial or cell adhesion, were obtained by copolymerization of hybrid peptide macromonomer with DCDMS, vinyl and silane reagents followed by hydrosilylation. Silicone-based NPs resulted from the introduction of several hydrophilic macromonomers at 0.5 to 1 mol% compared to DCDMS. Hybrid peptide ligands targeting cancer cell receptors, PEG and a drug model (Methotrexate) were prepared and copolymerized. At last, we investigated the preparation of siRNA polyplexes involving LysHis-based hybrid peptide macromonomers by an in situ polymerization method
Prencipe, G. "Newly tailored peptide nucleic acids (PNA) and PNA-modified magnetic nanoparticles for DNA targeting. PEG branched polymer chains functionalization of nano-systems for biocompatibility." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/180593.
Повний текст джерелаLindström, Fredrick. "Biological membrane interfaces involved in diseases : a biophysical study." Doctoral thesis, Umeå universitet, Kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-806.
Повний текст джерелаЧастини книг з теми "Branched peptide"
Hudecz, Ferenc, Gábor Dibó, Gábor Mező, Péter Kovács, Judit Kajtár, Gyula Szókán, and Mária Szekerke. "Chemical characterization of biodegradable branched polypeptides with polylysine backbone." In Peptide Chemistry 1992, 79–83. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_23.
Повний текст джерелаMezö, Gábor, and Ferenc Hudecz. "Synthesis of Linear, Branched, and Cyclic Peptide Chimera." In Peptide Synthesis and Applications, 63–76. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-877-3:063.
Повний текст джерелаKates, S. A., S. B. Daniels, N. A. Solé, G. Barany, and F. Albericio. "Automated allyl chemistry for solid-phase peptide synthesis: Applications to cyclic and branched peptides." In Peptides, 113–15. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_32.
Повний текст джерелаBobrova, I., N. Abissova, and A. Eremeev. "Synthesis of enkephalin analogues with linear, cyclic and branched structure of peptide chain." In Peptides 1990, 626–27. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_259.
Повний текст джерелаLi, Shun-Cheng, and Charles M. Deber. "Downward modulation of peptide helicity in membrane environments by Gly and β-branched residues." In Peptides 1992, 93–94. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_31.
Повний текст джерелаSabatier, Jean-Marc, Maxime Moulard, Emmanuel Fenouillet, Hervé Rochat, Jurphaas Van Rietschoten, and Kamel Mabrouk. "A multiple branch peptide construction derived from a conserved sequence of the envelope glycoprotein gp41 inhibits human immunodeficiency virus infection." In Peptides Frontiers of Peptide Science, 781–82. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/0-306-46862-x_340.
Повний текст джерелаKirby, D. A., S. C. Koerber, and J. E. Rivier. "High affinity, truncated, cyclic and branched analogs of Neuropeptide Y." In Peptides, 508–10. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_168.
Повний текст джерелаHudecz, F., M. J. Embleton, J. A. Clegg, J. Kajtár, M. V. Pimm, M. Szekerke, and R. W. Baldwin. "Branched polypeptide-daunomycin conjugates: Synthesis, conformation, cytotoxicity and biodistribution." In Peptides 1990, 806–7. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_334.
Повний текст джерелаHudecz, Ferenc. "Branched polymeric polypeptides with poly[Lys]." In Amino Acids, Peptides and Proteins, 44–90. Cambridge: Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781788013857-00044.
Повний текст джерелаHone, Neal D., Siri Ram Chhabra, Weng C. Chan, and Barrie W. Bycroft. "Novel Nε-lysine protection for the continuous flow SPPS of branched peptides." In Peptides 1992, 290–91. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_120.
Повний текст джерелаТези доповідей конференцій з теми "Branched peptide"
Brunetti, Jlenia, Lorenzo Depau, Chiara Falciani, Giulia Riolo, Elisabetta Mandarini, Alessandro Pini, and Luisa Bracci. "Abstract 3899: Preclinical development of tetra-branched NT4 peptide theranostics." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3899.
Повний текст джерелаAbel, Sabine, Bernhard Geltinger, Dirk Schwarzer, and Michael Beyermann. "Strategy for the Synthesis of Isotope-Labeled Branched Protein Mimics." In The Twenty-Third American and the Sixth International Peptide Symposium. Prompt Scientific Publishing, 2013. http://dx.doi.org/10.17952/23aps.2013.214.
Повний текст джерелаPark, Inkyung Angie, Steven Cwirla, Alice Bakker, Ronald Barrett, Michael Needels, Praechompoo Pongtornpipat, Blake Williams, Prarthana Joshi та William Dower. "1097 MDK1654: a branched synthetic peptide that activates both the IL-7 receptor and the βγc form of the IL-2/15 receptor". У SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1097.
Повний текст джерелаHudecz, Ferenc. "Immunorecognition of epitope peptides modified by flanking or conjugation to branched polypeptide carrier." In VIIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2001. http://dx.doi.org/10.1135/css200104007.
Повний текст джерелаFalciani, Chiara, Jlenia Brunetti, Barbara Lelli, Luisa Lozzi, Alessandro Pini, Niccolò Ravenni, Lapo Bencini, Stefano Menichetti, Renato Moretti, and Luisa Bracci. "Abstract A20: Tumor selective delivery of chemotherapeutics via branched peptides." In Abstracts: AACR International Conference on Translational Cancer Medicine--; Mar 21–24, 2010; Amsterdam, The Netherlands. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1078-0432.tcme10-a20.
Повний текст джерелаBracci, Luisa, Chiara Falciani, Alessandro Pini, Jlenia Brunetti, Barbara Lelli, Antonella Accardo, Diego Tesauro, and Giancarlo Morelli. "Abstract 2319: Target selective drug delivery through liposomes labeled with tetra-branched neurotensin peptides." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2319.
Повний текст джерелаBracci, Luisa, Chiara Falciani, Barbara Lelli, Jlenia Brunetti, Luisa Lozzi, Alessandro Pini, Chiara Pagliuca, et al. "Abstract 2582: Branched neurotensin peptides for the selective targeting of human colon and pancreas carcinoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2582.
Повний текст джерелаBrunetti, Jlenia, Lorenzo Depau, Chiara Falciani, Elisabetta Mandarini, Giulia Riolo, Giulia Roscia, Alessandro Pini, and Luisa Bracci. "Abstract 5350: Targeting Heparan Sulfated Proteoglycans by branched peptides for selective cancer imaging and therapy." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5350.
Повний текст джерела