Дисертації з теми "Brain wiring"
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Murphy, Alexander James. "RNA and Protein Networks That Locally Control Brain Wiring During Development." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467385.
Повний текст джерелаMedical Sciences
Espinosa, Juan Sebastian. "Genetic mosaic analysis of lineage and activity in wiring the mouse brain /." May be available electronically:, 2009. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Повний текст джерелаKhandelwal, Avinash 1987. "The wiring diagram of antennal lobe and mapping a brain circuit that controls chemotaxis behavior in the Drosophila larva." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/663806.
Повний текст джерелаLas larvas de Drosophila ofrecen una oportunidad única para el mapeo anatómico y funcional de su sistema nervioso debido a propiedades como la simplicidad numérica de neuronas que componen su sistema nervioso y su habilidad de exhibir comportamientos cuantificables como la quimiotaxis. En este estudio hemos mapeado el lóbulo antenal de la larva de Drosophila con uno de sus circuitos responsable de controlar la transformación sensorial-motora en el asta lateral (LH) (cerebro superior) a través de una sola neurona descendiente usando la reconstrucción 3D para microscopia electrónica. Hemos presentado, en el lóbulo antenal, un circuito canónico con proyecciones neuronales uniglomerulares (uPNs) responsables de transmitir aumentos controlados de actividad desde sus ORN* hasta centros superiores del cerebro como el cuerpo fungiforme y el asta lateral del protocerebro. Hemos descubierto también un circuito paralelo formado por neuronas con proyecciones multiglomerulares (mPNs) y neuronas locales (Lns), organizadas jerárquicamente, que integran selectivamente señales desde múltiples ORNs a nivel de primera sinapsis con conectividad LN-LN implementando aparentemente un mecanismo de aumento de control que potencialmente puede intercambiar señales olfativas distintas computacionalmente a través de inhibición panglomerular permitiendo al sistema responder a olores vagamente aversivos en un ambiente rico en fuertes olores apetitosos. También hemos reconstruido y estudiado uno de los circuitos olfativos que conectan con el LH conocido por influenciar la quimiotaxis de la larva a través de un sola neurona cerebral descendiente, la PVM027. Hemos descubierto que dicha neurona es la responsable de controlar la respuesta stop en el comportamiento de quimiotaxis. La reconstrucción por EM revela su conexión con una variedad de sistemas motores así como neuronas descendientes SEZ en el VNC. Observamos dichas conexiones gracias al circuito de propagación de onda peristáltica de la larva, y descubrimos que la PVM027 implementa la señal de stop terminando e interrumpiendo el origen de la onda peristáltica.
Eichler, Katharina [Verfasser]. "Mnemonic architecture of a mini-brain : determining the wiring diagram of the larval mushroom body of Drosophila melanogaster using EM reconstruction / Katharina Eichler." Konstanz : Bibliothek der Universität Konstanz, 2017. http://d-nb.info/1142788571/34.
Повний текст джерелаHasche, Anja. "Bindung von ATP an die Neurotrophine NGF und BDNF als Voraussetzung für ihre neuroprotektive Wirkung." Münster Schüling, 2008. http://d-nb.info/989241386/04.
Повний текст джерелаPruskil, Susanne. "Die neurotoxische Wirkung der Zytostatika Cyclophosphamid und Thiotepa im infantilen Gehirn der Ratte." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15439.
Повний текст джерелаSurvival rates for children with cancer have increased dramatically over the past few decades. The expanded use of older agents, the development of new chemotherapeutic agents, the introduction of high dose chemotherapy and stem cell transplantation regimen have had a major impact on this improvement. These positive results have also focused increased attention on post-therapeutic effects of anticancer drugs. To investigate whether common cytotoxic drugs cause neurotoxic effects in the developing rat brain the following alkylated agents were administered to 7-day-old rats: cyclophosphamide (200–600mg/kg IP) and thiotepa (15– 45mg/kg IP). The brains were analysed at 4 to 24 hours. Quantitation of brain damage was performed in De Olmos cupric silver-stained sections using the stereological dissector method. Furthermore electron microscopy on plastic sections, TUNEL staining and immunohistochemistry for activated caspase 3 and Fas receptor was performed. Statistical analysis was performed by means of Student´s t test or one-way analysis of variance with subsequent pairwise comparison (Scheffé-test). Cytotoxic drugs produced widespread lesions within cortex, thalamus, hippocampal dentate gyrus, and caudate nucleus in a dose-dependent fashion. Early histological analysis demonstrated dendritic swelling and relative preservation of axonal terminals, which are morphological features indicating excitotoxicity. After longer survival periods, degenerating neurons displayed morphological features consistent with active cell death. These results demonstrate that anticancer drugs are potent neurotoxins in vivo; they activate excitotoxic mechanisms but also trigger active neuronal death.
Miksa, Michael. "N-Methyl-D-Aspartat-Antagonisten induzierten apoptotische Zelluntergänge im Gehirn junger Ratten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15030.
Повний текст джерелаThe predominant excitatory neurotransmitter glutamate plays a major role in certain aspects of neural development. However, whether developing neurons depend on glutamate for survival remains unknown. To investigate if deprivation of glutamate stimulation in the immature mammalian brain causes neuronal cell death (apoptosis), rat pups aged 0 to 30 days were treated for 24 hours with dizocilpine maleate (MK801), an N-methyl-D-aspartate-(NMDA) glutamate receptor antagonist. Density of neural degeneration was evaluated by a stereological dissector method in cupric-silver and TUNEL-stained brain slices. Groups were compared by ANOVA and significance considered at p
Braun, Ariane [Verfasser], Michael Gutachter] Bucher, Oliver [Gutachter] Thews, and Markus A. [Gutachter] [Weigand. "Die Wirkung selektiver Cyclooxygenase-1- und Cyclooxygenase-2-Inhibition auf die Expression renaler Transporter für organische Anionen und die Nierenfunktion nach Ischämie und Reperfusion im Rattenmodell / Ariane Braun ; Gutachter: Michael Bucher, Oliver Thews, Markus A. Weigand." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-1981185920-331968.
Повний текст джерелаBraun, Ariane [Verfasser], Michael [Gutachter] Bucher, Oliver [Gutachter] Thews, and Markus A. [Gutachter] Weigand. "Die Wirkung selektiver Cyclooxygenase-1- und Cyclooxygenase-2-Inhibition auf die Expression renaler Transporter für organische Anionen und die Nierenfunktion nach Ischämie und Reperfusion im Rattenmodell / Ariane Braun ; Gutachter: Michael Bucher, Oliver Thews, Markus A. Weigand." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://d-nb.info/1210727382/34.
Повний текст джерелаMantovani, Michela [Verfasser], and Rolf [Akademischer Betreuer] Schubert. "Modulation of neocortical neurotransmissions by antidepressants and neuromodulatory drugs in human and rodent brain tissue and effect of electrical high-frequency stimulation in human neocortex = Modulation der Neokortikalen Neurotransmissionen durch Antidepressiva und Neuromodulatorische Substanzen im Hirngewebe von Menschen und Nagetieren und Wirkung der elektrischen Hochfrequenzstimulation im menschlichen Neokortex." Freiburg : Universität, 2012. http://d-nb.info/1123472971/34.
Повний текст джерелаMillett, David. "Wiring the brain : from the excitable cortex to the EEG, 1870-1940 /." 2001. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3006538.
Повний текст джерелаLin, Chih-Yung, and 林志勇. "A Comprehensive Wiring Diagram of the Protocerebral Bridge for Visual Information Processing in the Drosophila Brain." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/87753952395475441268.
Повний текст джерела國立清華大學
生物科技研究所
101
How the brain perceives sensory information and generates meaningful behavior depends critically on its underlying circuitry. The protocerebral bridge (PB) is a major part of the insect central complex (CX), a pre-motor center may be analogous to the human basal ganglia. Here, by deconstructing hundreds of PB single neurons and reconstructing them into a common 3D framework, we have constructed a comprehensive map of PB circuits with labeled polarity and predicted directions of information flow. Our analysis reveals a highly-ordered information processing system that involves directed information flow among CX subunits through 194 distinct PB neuron types. Circuitry properties such as mirror, convergence, divergence, tiling, reverberation and parallel signal propagation were observed; their functional and evolutional significances were discussed. This layout of PB neuronal circuitry may provide guidelines for further investigations on transformation of sensory (e.g. visual) input into locomotion command in fly brains.
Ng, David. "Wiring the brain with Neto1: A multivalent NMDA receptor interacting CUB domain protein with essential roles in axon guidance, synaptic plasticity, and hippocampal-dependant spatial learning and memory." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=449915&T=F.
Повний текст джерелаMahn, Brian [Verfasser]. "Untersuchungen zur Wirkung der Phenylacetylsäure auf die iNOS- Expression bei chronisch niereninsuffizienten Patienten / von Brian Mahn." 2006. http://d-nb.info/985017791/34.
Повний текст джерелаBraun, Andrea [Verfasser]. "Die Wirkung von Benzocain auf die Perzeption intraluminaler Dehnungsreize im menschlichen Rektum / vorgelegt von Andrea Braun." 2003. http://d-nb.info/970626940/34.
Повний текст джерела