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Готові списки джерел за темами / Brain microvascular endothelium / Дисертації

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Дисертації з теми "Brain microvascular endothelium"

Автор: Grafiati

Опубліковано: 11 березня 2023

Оновлено: 31 липня 2025

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1

Cerutti, Camilla. "Role of microRNAs in leukocyte adhesion to human brain microvascular endothelium." Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606835.

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MicroRNAs (miRs) are small non-coding regulatory RNAs that act through repression of protein translation and/or mRNA degradation at the post-transcriptional level. MiRs are critical players in the pathogenesis of many diseases, including 'neuroinflammatory disorders such as multiple sclerosis (MS), MS is characterized by leukocyte adhesion and infiltration subsequently leading to demyelination of nerve fibres. Leukocyte adhesion on brain endothelial cells (BEC) - the main cellular constituent of the blood-brain barrier (BBB) - is a complex multi-step process where activated BEC overexpress che

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2

Wang, Shiyang. "The role of TRKB receptors in regulation of coronary microvascular endothelial cell angiogenesis /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1543605071&sid=5&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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3

Genes-Hernandez, Luiza I. "Development of a microfluidic based microvascular model towards a complete blood brain barrier (BBB) mimic /." Diss., Connect to online resource - MSU authorized users, 2008.

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4

Al-sandaqchi, Alaa. "Interaction of Toxoplasma gondii with human brain microvascular endothelial cells in vitro." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37837/.

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Background: The brain is the most commonly affected organ during Toxoplasma gondii infection but the mechanisms utilized by this protozoan parasite for disrupting the brain's endothelial cells lining the blood–brain barrier (BBB) and moving to invade the brain are not yet understood. In the present study, we investigated the cellular pathogenicity of T. gondii infection in human brain microvascular endothelial cells (HBMECs), a fundamental component of the BBB. Methods: Intracellular development of T. gondii tachyzoites within HBMECs was characterized by using Acridine Orange (AO) staining. Th

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5

Pennucci, Roberta. "CDK5 : new insights into its biological function in human brain microvascular endothelial cells." Thesis, Manchester Metropolitan University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496791.

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Ischaemic stroke is a leading cause of death and disability worldwide Successful therapies reside in a precise knowledge of brain function and pathology. Towards this end, previous work in the MMU laboratory used cDNA microarrays to examine gene expression in an experimental rat model of ischaemic stroke - permanent MCAO - and for the first time in human brain tissue from ischaemic stroke patients. Novel deregulated genes were identified. This study was intended to confirm the reproducibility of the in vivo data in vitro. The results showed that human foetal (cerebral cortical) neurons (HFN),

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6

Casellato, Alessandro. "C2 Fragment from Neisseria meningitidis Antigen NHBA Disassembles Adherence Junctions of Brain Microvascular Endothelial Cells." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423368.

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Neisseria meningitidis is the major cause of meningitis and sepsis, two kind of diseases that can affect children and young adults within a few hours, unless a rapid antibiotic therapy is provided. The meningococcal disease dates back to the 16th century. The first description of the disease caused by this pathogen was stated by Viesseux in 1805 as 33 deaths occurred in Geneva, Switzerland [1]. It took about seventy years before two Italians (Marchiafava and Celli) in 1884 identified micrococcal infiltrates within the cerebrospinal fluid [2]. The worldwide presence of meningococcal serogroup

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7

Thomas, Sangeetha Mary. "An in-vitro study of intermedilysin toxin on human brain microvascular endothelial and other targets cells." Thesis, Queen Mary, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535840.

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8

Chao, Ying Sheng. "Development of quantitative real time PCR to assess human brain microvascular endothelial cell susceptibility to HIV-1 infection." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1450192.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed April 7, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 64-70).

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9

Loh, Lip Nam. "Eschericha coli Kl interactions with human brain microvascular endothelial cells, a primary step in the development of neonatal meningitis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://researchonline.lshtm.ac.uk/923208/.

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Escherichia coli (E. coli) Kl is one of the commonest Gram negative bacteria causing neonatal bacterial meningitis in both developed and developing countries. Haematogenous spread is a key step in E. coli Kl meningitis; however, it is not clear how bacteria cross the brain endothelium to gain entry into the central nervous system. Previous studies have focussed mainly on the identification of bacterial virulence factors, as well as the signalling pathways that are activated for the recruitment of actin cytoskeleton to the bacterial adhesion site on the apical surface of human brain microvascul

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10

ZUCCOLO, ESTELLA. "DIFFERENT PATTERNS OF Ca2+ SIGNALING DRIVE ACETYLCHOLINE AND GLUTAMATE INDUCED-NO RELEASE IN MOUSE AND HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELLS." Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1214896.

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Acetylcholine (Ach) and glutamate (Glu) are two of the major excitatory neurotransmitters in the brain which increase cerebral blood flow by releasing nitric oxide (NO) from postsynaptic neurons and astrocytes and causing vasorelaxationin adjacent microvessels. An increase in intracellular Ca2+ concentration recruits a multitude of endothelial Ca2+-dependent pathways, such as Ca2+/Calmodulin endothelial NO synthase (eNOS). Surprisingly, the Ca2+-dependent mechanisms whereby Ach induces NO synthesis in brain endothelial cells (ECs) is still unclear. On the other hand, Glu stimulates NMDA recept

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11

Holland, Kevin W. "Characterization and Application of Peanut Root Extracts." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/40264.

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Lipid oxidation is one of the leading causes of food quality degradation. Manufacturers typically add antioxidants or purge a productâ s package of oxygen to inhibit oxidation and the resulting off-flavors. Synthetic antioxidants (e.g. BHT, BHA) and some natural antioxidants (e.g. Î±-tocopherol) have found widespread use in this application. Unfortunately, the public views synthetic additives in a negative light and the current natural antioxidants have been unable to match the protection afforded by the synthetic antioxidants. The search for underutilized and natural antioxidants has led

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12

Ballard, Tameshia Shaunt'a. "Optimizing the Extraction of Phenolic Antioxidant Compounds from Peanut Skins." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28349.

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Peanut skins are a low-value byproduct of peanut blanching operations. They have been shown to contain significant levels of phenolic compounds with demonstrated antioxidant properties. The effects of two types of extraction methods: solid-liquid extraction (SLE) and microwave-assisted extraction (MAE) on the recovery of phenolic compounds from peanut skins were investigated. Response surface methodology was used to optimize extraction conditions based on total phenolic content (TPC), ORAC (oxygen radical absorbance capacity) activity and <i>trans</i>-resveratrol content. The protective effect

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13

Rennel, Emma. "Molecular Mechanisms in Endothelial Cell Differentiation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4059.

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14

Halle, Annett. "Streptococcus pneumoniae induziert Apoptose in zerebralen Endothelzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15193.

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Die bakterielle Meningitis ist trotz der Anwendung modernster Antibiotika mit einer hohen Letalität und neurologischen Spätkomplikationen verbunden. Ein entscheidendes Ereignis ist dabei der Zusammenbruch der Blut-Hirn-Schranke (BHS). Die genauen Mechanismen, die zu ihrer Schädigung führen, sind bis heute unklar. In dieser Arbeit wurde untersucht, ob lebende Pneumokokken in einem Zellkulturmodell der BHS zu einer apoptotischen Zellschädigung von zerebralen Endothelzellen, als wichtigstem zellulären Bestandteil der BHS, führen und damit zu ihrer strukturellen Schädigung beitragen. Mittels versc

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15

Sehmsdorf, Ute-Stephani. "Einfluss von "Calcitonin Gene-Related Peptide" und "Substance P" auf die mRNA-Expression und Freisetzung von Zytokinen aus zerebralen Endothelzellen bei Kostimulation mit Pneumokokkenzellwänden." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/14660.

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Die bakterielle Meningitis (BM) ist trotz antibiotischer Therapie eine Erkrankung mit einer hohen Mortalität und Morbidität. Kopfschmerzen und Meningismus sind Hauptsymtome und ein klinischer Hinweis für die Aktivierung trigeminaler Fasern. Ziel dieser Arbeit war es zu prüfen ob die freigesetzten Neuropeptide einen proinflammatorischen Effekt auf zerebrale Endothelzellen, einen wesentlichem Bestandteil der Blut-Hirn-Schranke haben. Wir verwendeten primär kultivierte zerebrale Kapillarendothelzellen (BMEC) der Ratte und als Stimulus Neuropeptide und/oder Pneumokokkenzellwände (PCW). Beide Neur

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16

Radu, Beatrice Mihaela. "Brain microvessels and neuronal excitability: who is exciting who?" Doctoral thesis, 2017. http://hdl.handle.net/11562/967633.

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The working hypothesis is that any stimulus acting on brain microvascular endothelium, might activate the neurovascular unit by intercellular crosstalk, and consequently could increase neuronal hyperexcitability. The first chapter presents the concept of neurovascular unit. Interactions between neurovascular unit components are also discussed, and their involvement in ictogenesis. The second chapter describes the aim of the thesis, the main objectives and the principal technical approaches used in the study. The third chapter is dedicated to the elusive interaction between Qtracker®800 vascula

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17

Lai, Ching-Yi, and 賴慶憶. "Japanese encephalitis virus infection activates brain microvascular endothelial cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/38819858991501058287.

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博士<br>國立中興大學<br>生命科學系所<br>101<br>Currently, the underlying mechanisms and the specific cell types associated with Japanese encephalitis-associated leukocyte trafficking are not understood. Brain microvascular endothelial cells represent a functional barrier and could play key roles in leukocyte central nervous system trafficking. We found that cultured brain microvascular endothelial cells were susceptible to Japanese encephalitis virus (JEV) infection with limited amplification. This type of JEV infection had negligible effects on cell viability and barrier integrity. Instead, JEV-infected en

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18

Pong, Sovannarath. "Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report." Thesis, 2020. https://hdl.handle.net/2144/41156.

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Disruption of the blood-brain barrier (BBB) is hypothesized to play an important role in the disease biology of schizophrenia (SZ). Brain microvascular endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which collectively contribute to maintaining proper BBB function. While previous studies have provided some insights into the role of the BBB in SZ pathophysiology, there is a significant gap in our understanding of the cellular-molecular underpinnings of its major component, BMECs. Human induced pluripotent

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19

CHEN, YIN-CHEN, and 陳吟貞. "To Evaluate the Effect and Mechanism of Natural Products on Brain Microvascular Endothelial Cell-Dependent Brain Inflammation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/36vy3j.

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碩士<br>長庚科技大學<br>健康產業科技研究所<br>107<br>As the population of the world ages, the elderly population and aging-related disorders are also increasing. Therefore, in recent years, most studies have focused on the aging-related disorders, the central nervous system (CNS) degenerative diseases particularly. These CNS disorders include traumatic brain injury, stroke, neuroinflammation, and neurodegeneration. It is known that endothelial cells of Blood-Brain-Barrier (BBB) in patients with neurodegenerative diseases usually have an inflammatory state, but the mechanisms are still unclear. Here, we use the

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20

"Paradoxical Effects Of Nitric Oxide Synthase Isoforms In Brain Microvascular Endothelial Cells And Neurons." Tulane University, 2018.

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archives@tulane.edu<br>Experimental stroke in endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) knockout mice showed diverse effects on brain injury. nNOS and eNOS have been shown to uncouple in pathological conditions to produce superoxide. Oxidative stress is believed to be the underlying cause of several cardiovascular diseases including ischemic stroke. However, the role of eNOS and nNOS uncoupling in ischemic stroke is not well studied. Our objective of the study was to determine the effect of eNOS and nNOS inhibition on reactive oxygen species (ROS), NO,

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21

Lee, Chin-Lung, and 李景隆. "A Further Representative In Vitro Human Blood-Brain Barrier Model: Human Brain Microvascular Endothelial Cells Regulated By Human Brain Vascular Pericytes And Human Astrocytes." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/hxftty.

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碩士<br>國立中正大學<br>化學工程研究所<br>100<br>We constructed in vitro human blood-brain barrier (BBB) model using pericyte-condition medium (PCM) and astrocyte-condition medium and different ratio between human brain vascular pericytes (HBVPs) and human astrocytes (HAs) (1: 1, 1: 2, 1: 6) co-culture with human brain microvascular endothelial cells (HBMECs). After 7 days of co-culture of HBMECs, HBVPs, HAs (HBVPs:HAs=1: 2), PCM2, ACM2 (PCM: ACM= 1: 1), the transendothelial electrical resistance (TEER) increased to 319±16.67 Ω×cm2, reduced permeability of propidium iodide (PI) about 39 %. The activity of P-

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22

Nikulin, Joanna. "Untersuchungen zu intrazellulären Folgereaktionen von Neisseria meningitidis und Escherichia coli K1 in HBMEC (human brain microvascular endothelial cells)." Doctoral thesis, 2005. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-16552.

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Neisseria meningitidis ist einer der wichtigsten Erreger bakterieller Meningitiden und gefürchtet für das Potential Epidemien auszulösen. Die Meningokokken-Meningitis bleibt bis heute auch in Industrieländern mit hoher Mortalität verbunden. Um eine Meningitis verursachen zu können, müssen Meningokokken die Blut-Hirn/Liquor-Schranke überqueren. Dies erfolgt vermutlich über den transzellulären Weg durch die Endothelzellbarriere der Gehirnkapillare. Ereignisse unmittelbar vor der bakteriellen Internalisierung sind vielfach untersucht, noch wenig erforscht sind jedoch die in der Endothelzelle durc

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23

Lo, Yeung Y. "In-vitro characterization of human brain microvascular endothelial cells infected with West Nile virus to study tight junction integrity." Thesis, 2008. http://hdl.handle.net/10125/20444.

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24

Chang, Ching I., and 張靜怡. "15-Deoxy-Delta-12,14-prostaglandin J2 induces HO-1 expression and its anti-inflammatory effect in mouse brain microvascular endothelial cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/3zaaab.

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碩士<br>長庚大學<br>生物醫學研究所<br>104<br>Endothelial cells (ECs) exist in all the organ systems and regulate the flow of diverse nutrient substances and biologically active molecules. The brain is lined by continuous ECs connected by tight junctions that help to maintain the blood-brain barrier (BBB). The abnormal function(s) of bEnd.3Cs, causing by inflammation, oxidative stress or other kinds of diseases, will result in malfunction of BBB. HO-1 catalyzes the cleavage of heme molecule to produce carbon monoxide (CO), bilirubin and iron. The HO-1-catalyzed heme degradation also plays a critical role in

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25

Nikulin, Joanna [Verfasser]. "Untersuchungen zu intrazellulären Folgereaktionen von Neisseria meningitidis und Escherichia coli K1 in HBMEC (human brain microvascular endothelial cells) / vorgelegt von Joanna Nikulin." 2006. http://d-nb.info/978285395/34.

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26

Lin, Che-Wei, and 林哲緯. "Effect of Electromagnetic Field on the Electrophoretic Mobility and the Electrophoretic Softness of SLN, R-SLN, and Human Brain Microvascular Endothelial Cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/74329821313577110080.

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碩士<br>國立中正大學<br>化學工程所<br>95<br>The study aims to the electrophoretic mobility and the softness of solid lipid nanoparticles (SLN) composed of cocoa butter and tripalmitin as lipid phase, L-arginine loaded SLN (R-SLN), and human brain microvascular endothelial cells (HBMECs) were investigated under the influences of electromagnetic field with various power. The size of SLN and R-SLN were measured by zetasizer and confirmed by the images of FE-SEM and TEM. The softness, fixed charge density, and Donnan potential were estimated from the electrophoretic mobility of capillary electrophoresis and th

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27

Bleau, Christian. "Rôle des cellules endothéliales dans l’immunité innée précoce induite lors d’infections par des coronavirus murins." Thèse, 2015. http://hdl.handle.net/1866/13913.

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Les cellules endothéliales (EC) constituent une première barrière physique à la dissémination de virus pléiotropiques circulant par voie hématogène mais leur contribution à la défense innée anti-virale est peu connue. Des dysfonctions des EC de la barrière hémato-encéphalique (BMEC) et des sinusoïdes hépatiques (LSEC) ont été rapportées dans des neuropathologies et des hépatites aiguës ou chroniques d’origine virale, suggérant que des atteintes à leur intégrité contribuent à la pathogenèse. Les sérotypes de coronavirus de l’hépatite murine (MHV), se différenciant par leur capacité à induire de

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28

Puscas, Ina. "Développement d’un modèle in vitro de la barrière hémato-encéphalique." Thesis, 2019. http://hdl.handle.net/1866/24000.

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La barrière hémato-encéphalique (BHE) est une structure retrouvée au niveau des capillaires cérébraux. Elle représente un véritable obstacle pour les actifs qui doivent se rendre au cerveau pour y exercer un effet pharmacologique. Durant les étapes du développement du médicament, des modèles cellulaires in vitro sont utilisés pour l’évaluation de la perméabilité au cerveau des nouveaux médicaments. Le modèle assemblé avec des cellules endothéliales (CEs) isolées des capillaires des cerveaux de souris présente un intérêt particulier pour la recherche en raison de sa facilité d’obtention et sa p

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