Дисертації з теми "Brain-derived neurotropic factor"
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Khundakar, Ahmad Adam. "The effect of antidepressant treatment on brain-derived neurotropic factor expression in the rat hippocampus." Thesis, De Montfort University, 2004. http://hdl.handle.net/2086/13266.
Повний текст джерелаAgerman, Karin. "Specificity of neurotrophins in the nervous system : a genetic approach to determine receptor engagement by neurotrophins /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-730-4/.
Повний текст джерелаLinnarsson, Sten. "Neurotrophic factors and neuronal plasticity /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4618-3/.
Повний текст джерелаGunther, Erik Christian. "Molecular mechanisms of brain derived neurotrophic factor secretion and action /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5086.
Повний текст джерелаMartinez, Humberto Jose. "Nerve growth factor actions on the brain /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744572291&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаWu, Linyan, and wu0071@flinders edu au. "BRAIN DERIVED NEUROTROPHIC FACTOR TRANSPORT AND PHYSIOLOGICAL SIGNIFICANCE." Flinders University. Medicine, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20071204.113001.
Повний текст джерелаPalm, Kaia. "Regulation of neuronal gene expression /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980612palm.
Повний текст джерелаAndroutsellis-Theotokis, Andreas. "The release and distribution of brain derived neurotrophic factor in brain." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266203.
Повний текст джерелаKawamoto, Yasuhiro. "Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain." Kyoto University, 1997. http://hdl.handle.net/2433/202181.
Повний текст джерелаRoeding, Ross L., Marla K. Perna, Elizabeth D. Cummins, Daniel J. Peterson, Matthew I. Palmatier, and Russell W. Brown. "Sex Differences in Adolescent Methylphenidate Sensitization: Effects on Glial Cell-Derived Neurotrophic Factor and Brain-Derived Neurotrophic Factor." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/952.
Повний текст джерелаZhu, Shun-Wei. "Brain neurotrophin levels and mouse behavior : relationship to environmental influences /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-843-6/.
Повний текст джерелаGoggi, Julian Luke. "Brain-derived neurotrophic factor and modulation of synaptic output." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399537.
Повний текст джерелаAlqudah, Mohammad. "Characterization of the neurotrophic factor Brain-Derived Neurotrophic Factor (BDNF) in intestinal smooth muscle cells." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3095.
Повний текст джерелаChen, Hui. "Neuronal Glucocorticoid Receptor Regulation of Brain Derived Neurotrophic Factor Expression." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS242/document.
Повний текст джерелаIn the central nervous system (CNS), the hippocampus is a structure of major importance for cognitive and behavioral functions. The brain-derived neurotrophic factor (BDNF), a key player in such neuronal functions is highly expressed in the hippocampus. Rodent Bdnf gene structure is relatively complex, composed of 8 noncoding exons (I to VIII), each one with a specific promoter (1 to 8), and one common coding exon IX. Glucocorticoids (GC) exert pleiotropic actions on neuronal processes by binding to and activating the glucocorticoid receptor (GR), as well as the mineralocorticoid receptor (MR). GR functions as a transcription factor, directly by interacting to glucocorticoid response elements or indirectly by interacting with other transcription factors, leading to the regulation of target gene transcription. It has been suggested that Bdnf expression is regulated by stress and high GC concentrations. However, it remains to define whether Bdnf is a GR target gene and what are the underlying molecular mechanisms. Herein, we demonstrate that high GC levels downregulate total Bdnf mRNA expression via GR in various in vitro neuron-like cellular models. In primary cultures of mouse hippocampal neurons and BZ cells, BDNF IV- and VI-containing transcripts are involved in this regulatory mechanism. Moreover, in transient transfections, promoter 4 activity was reduced by activated GR. Furthermore, ChIP analysis and mutagenesis experiments demonstrate that the GR-induced repression on Bdnf expression and transcriptional activities occurs through GR binding to a small 74 bp promoter sequence upstream of exon IV. The exact GR binding site on DNA and its putative transcription factor partners are currently under investigation. Altogether, these findings contribute to a better understanding of the mechanisms by which GR represses BDNF expression. Our study brings new insights into the molecular interactions between GC signaling and BDNF signaling in neurons, both important pathways in the pathophysiology of the CNS
Advani, Tushar M. "Brain derived neurotrophic factor deficient mouse a putative model of allostatic overload : a dissertation /." San Antonio : UTHSC, 2008. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1588771861&sid=7&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Повний текст джерелаRobinson, Amy Ann. "Quantification of brain-derived neurotrophic factor expression in the aging monkey brain." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11035.
Повний текст джерелаWhile early studies of normal aging largely focused on the loss of neurons as a basis of cognitive aging, current studies of both aging humans and the rhesus monkey model of normal aging demonstrate that forebrain neurons are largely preserved. Instead, MRI and electron microscopic analyses show that age-related changes in the white matter are good predictors of cognitive impairment. White matter changes include an increase in damaged myelin sheaths as well as a loss of myelinated fibers. To explore potential causes of the white matter alterations, the expression of genes related to myelination and axonal survival were examined revealing age-related alterations in the expression of 9 genes in grey matter and 7 in subcortical white matter of the inferior parietal lobule (IPL). Four were selected for further analysis. Of these, brain-derived neurotrophic factor (BDNF) had a statistically significant decrease in expression in the cortical grey matter of the IPL at both the level of gene expression and of protein expression. In 27 male and female rhesus monkeys ranging from young to old, the precursor form of BDNF (proBDNF) was significantly decreased while the mature form was preserved. In order to understand the localization of the age-related decline in proBDNF, immunohistochemical reactivity was quantified in the IPL and in the hippocampus. In the IPL there was a significant decrease in total immunohistochemical reactivity. Further analysis showed that there was an increase in the number of proBDNF positive somata while there was no change in the smaller extrasomal puncta. This increase in cell bodies expressing proBDNF despite the age-related decrease in total proBDNF immunohistochemical density suggests disruption of post-translational processing and/or transport out into the processes. In contrast to the IPL, there was no change in proBDNF density in the hippocampus with age. However, in the hippocampus but not the IPL, proBDNF immunohistochemical reactivity was sexually dimorphic with higher levels in the female monkeys compared to males. While the significance of the change in proBDNF levels for myelin damage is unclear, alteration in this neurotrophin may play a role in the axon loss that accompanies myelin degradation.
Klein, Inna. "Einfluss des Brain-derived neurotrophic factor auf Schizophrenie und Gedächtnisleistungen." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-162685.
Повний текст джерелаBalog, Brian Michael. "Brain-Derived Neurotrophic Factor Mediates Recovery from Stress Urinary Incontinence." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1602113592326106.
Повний текст джерелаWardle, Rinda A. "Modulation of inhibitory synaptic transmission by brain-derived neurotrophic factor /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3094613.
Повний текст джерелаTraver, Kyle Leann. "Environmental Enrichment-Mediated Neuroprotection Against Traumatic Brain Injury:Role of Brain-Derived Neurotrophic Factor." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1307129480.
Повний текст джерелаHing, Benjamin. "Investigating differential regulation of BDNF promoter IV activity by upstream polymorphic evolutionary conserved regions : implications for mood disorders and cognitive disfunction." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185597.
Повний текст джерелаHasche, Anja. "Bindung von ATP an die Neurotrophine NGF und BDNF als Voraussetzung für ihre neuroprotektive Wirkung." Münster Schüling, 2008. http://d-nb.info/989241386/04.
Повний текст джерелаLam, Chi-tat. "Identification of brain-derived neurotrophic factor (BDNF) as a novel angiogenic factor in tumor angiogenesis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290355.
Повний текст джерелаBerghuis, Paul. "Brain-derived neurotrophic factor and endocannabinoid functions i GABAergic interneuron development /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-125-8/.
Повний текст джерелаVon, dem Bussche Mary. "The role of brain-derived neurotrophic factor in cortical motor learning." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3284226.
Повний текст джерелаTitle from first page of PDF file (viewed January 11, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
REIBEL, FOISSET SOPHIE. "Role du brain-derived neurotrophic factor dans l'epileptogenese chez le rat." Université Louis Pasteur (Strasbourg) (1971-2008), 1999. http://www.theses.fr/1999STR13037.
Повний текст джерелаTsuchida, Atsushi. "Action Mechanism of Brain-Derived Neurotrophic Factor in Regulating Glucose Metabolism." Kyoto University, 2002. http://hdl.handle.net/2433/149508.
Повний текст джерелаIngram, James David. "The identification of inhibitors of nerve growth factor and brain-derived neurotrophic factor." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/422241/.
Повний текст джерелаZhou, Xiangdong. "Brain-derived Neurotrophic Factor in Autonomic Nervous System: Nicotinic Acetylcholine Receptor Regulation and Potential Trophic Effects." Connect to full-text via OhioLINK ETD Center, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1130160629.
Повний текст джерела"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Joseph F. Margiotta. Includes abstract. Document formatted into pages: iii, 226 p. Title from title page of PDF document. Bibliography: pages 80-92,130-139,149-225.
Angelucci, Francesco. "Antidepressive and antipsychotic treatments : effects on nerve growth factor and brain-derived neurotrophic factor in rat brain /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-226-4.
Повний текст джерелаWissman, Anne Marie. "Neurotrophins and seasonal plasticity in the avian song control system /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10661.
Повний текст джерелаWang, Shiyang. "The role of TRKB receptors in regulation of coronary microvascular endothelial cell angiogenesis /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1543605071&sid=5&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаMontag, Christian. "Die revidierte reinforcement sensitivity theory eine experimentell-biologische Überprüfung." Hamburg Kovač, 2008. http://d-nb.info/993570275/04.
Повний текст джерелаLiu, Ping. "Blood brain-derived neurotrophic factor (BDNF) expression in normal humans and schizophrenic patients." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31352121.
Повний текст джерелаHansson, Anita Christiane. "Gluco- and mineralocorticoid receptor regulation of regional brain neurotrophism /." Stockholm : Karolinska institutets bibl, 2002. http://diss.kib.ki.se/2002/91-7349-280-9.
Повний текст джерелаBerk, Benjamin-Andreas. "Brain-derived neurotrophic factor-induzierte neuroprotektive Osmoregulation der Müller-Gliazelle der Rattenretina." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170385.
Повний текст джерелаIntroduction: Tissue edema is a major blinding complication of ischemic-hypoxic and inflammatory retinal diseases. In addition to the hyperpemeability of the blood-retinal barrier, water accumulation in retinal cells resulting in cellular swelling may contribute to the development of retinal edema. Müller glial cells regulate the retinal ion and water homeostasis by allowing transcellular ion and water fluxes. During neuronal activity Müller cells control the extracellular space volume by autocrine inhibition of cellular swelling caused by the reduction of extracellular osmolarity. However, under pathological conditions, Müller cells are not capable to regulate their volume so that they swell rapidly under hypoosmolarity. The osmotic swelling of Müller glial cells and the glutamate induced swelling of retinal neurons contribute to the development of cytotoxic retinal edema. Various neuroprotective factors including brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF) stimulate the survival of retinal neurons and thus delay the retinal degeneration. Objective: The objective of the study is to determine whether BDNF inhibits the osmotic swelling of Müller and bipolar cells of the rat retina. Material and Methods: Retinal slices and freshly isolated Müller and bipolar cells of 55 adult Long-Evans rats (in average 8-15 cells per trial) were used. Osmotic swelling of Müller and bipolar cells was induced by superfusion of retinal slices or isolated cells with a 60% hypoosmotic extracellular solution in the absence or presence of barium chloride. The maximal cross-sectional area of Müller and bipolar cell somata was recorded before and after a four minute-long superfusion by using a laser scanning microscope. To determine the extent of cell soma swelling, the cross-sectional area of the cell body extent after superfusion was related to the former averaged cross-sectional area. Results were given as means with standard error as percent values. Statistical analysis was made with Prism (Graphpad) and the significance was determined by the One-way ANOVA test followed by Bonferroni\'s multiple comparison test and the Mann-Whitney U test, respectively. Results: We found that BDNF inhibits dose-depending the osmotic swelling of Müller cells in retinal slices and of isolated cells. BDNF also inhibited dose-depending the osmotic swelling of bipolar cells in retinal slices; however, it did not inhibit the osmotic swelling in isolated bipolar cells. In slices of postischemic retinas, BDNF inhibited the swelling of Müller cells but not the swelling of bipolar cells. The BDNF induced signal transduction cascade was examined by simultaneous administration of blocking agents with the receptor agonists in the hypoosmotic solution. The BDNF-induced inhibition of the osmotic Müller cell swelling was mediated by activation of TrkB. Activation of TrkB in Müller cells results in transactivation of FGF receptors and in an activation of a glutamatergic-purinergic signal transduction cascade which is known to inhibit the osmotic swelling of the cells. Since bFGF also inhibits the osmotic swelling of Müller cells, it can be assumed that the transactivation of FGF receptors is mediated by a BDNF-induced release of bFGF from Müller cells. The results suggest that the effect of BDNF on bipolar cells is indirect by inducing a subsequent release of glial factor from Müller cells such as bFGF. Conclusion: The results show that BDNF inhibits the osmotic swelling of Müller and bipolar cells. The inhibition of cytotoxic cell swelling may contribute to the neuroprotective action of BDNF in the retina. While BDNF acts directly in Müller cells, the BDNF-induced inhibition of the bipolar cell swelling is indirect and mediated by the release of glial factors such as bFGF from Müller cells. The abrogation of the BDNF-induced inhibition of the osmotic bipolar cell swelling in the postischemic retina could be explained with the impairment of the release of glial factors by Müller cells. The abrogation of the Müller cell-mediated regulation of the bipolar cell volume could contribute to the neuronal degeneration in the ischemic retina
Peterson, Daniel J., Elizabeth D. Cummins, Stephen B. Griffin, and Russell W. Brown. "Methylphenidate Conditioned Place Preference: Role of D1 Receptors and Brain-derived Neurotrophic Factor." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/961.
Повний текст джерела歐穎嫻 and Wing-han Au. "Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinaseB (TRKB) signaling in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557947.
Повний текст джерелаLam, Chi-tat, and 林知達. "Identification of brain-derived neurotrophic factor (BDNF) as a novel angiogenic factor in tumor angiogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290355.
Повний текст джерелаAu, Wing-han. "Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TRKB) signaling in ovarian cancer." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557947.
Повний текст джерелаLiu, Ping, and 劉苹. "Blood brain-derived neurotrophic factor (BDNF) expression in normal humans and schizophrenic patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31352121.
Повний текст джерелаLang, Susanne. "Imaging brain-derived neurotrophic factor-mediated calcium signaling and plasticity in developing neurons." Diss., [S.l.] : [s.n.], 2007. http://edoc.ub.uni-muenchen.de/archive/00006770.
Повний текст джерелаPfaffenseller, Bianca, Flavio Kapczinski, Amelia L. Gallitano, and Fábio Klamt. "EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder." FRONTIERS MEDIA SA, 2018. http://hdl.handle.net/10150/627052.
Повний текст джерелаRay, Sutapa Jones Kevin R. "Brain-derived neurotrophic factor is required for normal peripheral nerve development and regeneration." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/dissertations/fullcit/3165831.
Повний текст джерелаLeavesley, Rachel Claire. "Expression and regulation of brain-derived neurotrophic factor in rat dorsal root ganglia." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409124.
Повний текст джерелаCurrie, James. "Blood concentration of brain-derived neurotrophic factor (BDNF) and physical activity in humans." Thesis, Oxford Brookes University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543844.
Повний текст джерелаSzabo, Ashley J. "Brain-Derived Neurotrophic Factor Genotype and Cognitive Functioning in Individuals with Cardiovascular Disease." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1278634648.
Повний текст джерелаBergin, Stephen Michael. "Hypothalamic brain-derived neurotrophic factor regulates lymphocyte immunity, energy balance, and cancer progression." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487669797216355.
Повний текст джерелаOkano, Takayuki. "Cell-gene delivery of brain-derived neurotrophic factor to the mouse inner ear." Kyoto University, 2008. http://hdl.handle.net/2433/135804.
Повний текст джерелаMerrill, David A. "Mechanisms underlying age-related cognitive decline and sensitivity to brain-derived neurotrophic factor /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3059907.
Повний текст джерела