Статті в журналах з теми "Bower manuscript"
Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Bower manuscript.
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 статей у журналах для дослідження на тему "Bower manuscript".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.
1
Leonti, Marco, and Laura Casu. "Soma, food of the immortals according to the Bower Manuscript (Kashmir, 6th century A.D.)." Journal of Ethnopharmacology 155, no. 1 (August 2014): 373–86. http://dx.doi.org/10.1016/j.jep.2014.05.029.
Повний текст джерела
2
Clanchy, Michael. "Images of Ladies with Prayer Books: What do they Signify?" Studies in Church History 38 (2004): 106–22. http://dx.doi.org/10.1017/s042420840001576x.
Повний текст джерелаАнотація:
Monastic illumination of manuscripts gave to writings a force and prestige which was unprecedented. Throughout the millennium of western monasticism (500-1500 A.D.), the rich founded monasteries so that monks might pray and worship on their behalf. The monks displayed the fruit of their labours to their patrons in their churches and other works of art, particularly in their books. When with growing prosperity from about 1250 onwards the demand for individual prayer reached down to the middle class of knights and burgesses, they began to want wonderworking books of their own. They could not afford to buy a chantry chapel or a jewelled reliquary, but a small illuminated manuscript came within their means as the first step towards the purchase of paradise. Ladies in particular took to reciting the Latin Psalter and treasuring illuminated Books of Hours. In fifteenth-century depictions of the Annunciation, Mary is often shown seated in a sunlit bower with an open Book of Hours on her lap or displayed on a lectern. Likewise she is sometimes depicted with the Child Jesus on her knee, showing him a Book of Hours. The habit of possessing books might never have reached the laity if writing had not been so luxurious and so covetable. Illumination introduced the laity to script through images which could not fail to attract the eye. The children of the prosperous were introduced to the Psalter by their mothers or a priest for the purpose both of learning to read and of beginning formal prayer. To own a Psalter was therefore an act of familial as well as public piety.These words were written twenty years ago, for a conference at the Library of Congress in 1980 on ‘Literacy in historical perspective’. Since then, these themes have been addressed in several lectures and research papers at conferences, and I would stand by the main ideas expressed in that passage. Monks had indeed given extraordinary prestige to books and in particular to the illuminated liturgical book, which is a medieval invention. By the thirteenth century such books were being adapted for lay use and ownership, typically in Books of Hours. However, it is mistaken to say that lay use ‘began’ then, as the aristocracy – particularly in Germany – had been familiar with prayer books for centuries. In the twelfth century, Hildegard of Bingen was said to have learned only the Psalter ‘as is the custom of noble girls’. A Psalter for lay use dating from c.1150, which belonged to Clementia von Zähringen, has been preserved. It contains a full-page portrait of a lady – presumably Clementia herself – at folio 6v between the end of the Calendar and the Beatus page beginning the Psalms. This book has 126 folios in its present state (possibly one folio is missing at the end) and it measures 11 cm X 7 cm, no larger than a woman’s hand. The biography of Marianus Scotus, the eleventh-century Irish hermit who settled at Regensburg, describes how he wrote for poor widows and clerics ‘many little books and many Psalter manuals’ (‘multos libellos multaque manualia psalteria’). The diminutive form ‘libellos’ and the adjective ‘manualia’ emphasise that these manuscripts were small enough to hold in the hand, like Clementia von Zähringen’s book.
3
Garcia, Francisco A. R., and Joel M. Childers. "Laparoscopic Bowel Injuries Among Gynecologic Patients." Diagnostic and Therapeutic Endoscopy 3, no. 4 (January 1, 1997): 241–47. http://dx.doi.org/10.1155/dte.3.241.
Повний текст джерелаАнотація:
Bowel injury is an uncommon but recognized risk of operative laparoscopy. Because of the significant morbidity that can occur with this complication, it is important that clinicians be aware of its incidence, presentation, and management. This manuscript outlines the common causes of bowel injury, including herniation and traumatic bowel perforation. Management of laparoscopic bowel injuries is discussed and recommendations are made for avoidance of such complications.
4
Bokova, Elizaveta, Wendy Jo Svetanoff, John M. Rosen, Marc A. Levitt, and Rebecca M. Rentea. "State of the Art Bowel Management for Pediatric Colorectal Problems: Functional Constipation." Children 10, no. 6 (June 19, 2023): 1078. http://dx.doi.org/10.3390/children10061078.
Повний текст джерелаАнотація:
Background: Functional constipation (FC) affects up to 32% of the pediatric population, and some of these patients are referred to pediatric surgery units to manage their constipation and/or fecal incontinence. The aim of the current paper is to report the recent updates on the evaluation and management of children with FC as a part of a manuscript series on bowel management in patients with anorectal malformations, Hirschsprung disease, spinal anomalies, and FC. Methods: A literature search was performed using Medline/PubMed, Google Scholar, Cochrane, and EMBASE databases and focusing on the manuscripts published within the last 5–10 years. Results: The first step of management of children with FC is to exclude Hirschsprung disease with a contrast study, examination under anesthesia, anorectal manometry (AMAN). If AMAN shows absent rectoanal inhibitory reflex, a rectal biopsy is performed. Internal sphincter achalasia or high resting pressures indicate botulinum toxin injection. Medical management options include laxatives, rectal enemas, transanal irrigations, and antegrade flushes. Those who fail conservative treatment require further assessment of colonic motility and can be candidates for colonic resection. The type of resection (subtotal colonic resection vs. Deloyer’s procedure) can be guided with a balloon expulsion test. Conclusion: Most of the patients with FC referred for surgical evaluation can be managed conservatively. Further studies are required to determine an optimal strategy of surgical resection in children unresponsive to medical treatment.
5
Novichkov, Aleksei Valer'evich, and Aleksei Anatol'evich Reznikov. "MILITARY-STRATEGIC PREPARATION OF GREAT BRITAIN DURING THE SECOND ANGLO-BOER WAR." Manuscript, no. 4 (May 2018): 55–58. http://dx.doi.org/10.30853/manuscript.2018-4.11.
Повний текст джерела
6
Kajdańska, Aleksandra. "Transkulturowe znaczenie ksiąg ubioru na przykładzie hiszpańskiego Boxer Codex w nowożytnej Europie." Gdańskie Studia Azji Wschodniej, no. 24 (December 2023): 215–36. http://dx.doi.org/10.4467/23538724gs.23.033.19028.
Повний текст джерелаАнотація:
The transcultural significance and the significance for costuming of a book on dress: The Boxer Codex in early-modern Europe The Boxer Codex is a Spanish manuscript dated approximately to 1590. It was written in the Philippines in Manila, having been commissioned by the contemporary governor of Manila, Gomez Pérez Desmariñas. The document is called after the name of the last private owner of the codex, Charles R. Boxer, a historian and specialist on the history of colonialism in Asia. It contains illustrations showing figures in costumes representing peoples living in areas colonized by the Spaniards in Asia (The Philippines) and neighbouring lands, such as China, Japan, the Spice Islands (the Moluccas), Brunei, Java, Siam (Thailand), Northern and Central Vietnam, and others. Alongside the illustrations are texts describing the geography and customs of the minorities who live there; these, research shows, may be copies from the work of Martin de Rada, Miguel Rojo de Brito, and other anonymous authors. This article examines the manuscript from the perspective of costume studies. Because of the very extensive material in the manuscript, the author has selected several illustrations connected with Chinese dress in order to show its richness and the first European view of Chinese culture on the threshold of modern times. The author juxtaposes these with the already well-known accounts of the Polish sinologist Michał Boym (1612-1659). Boym’s accounts of Chinese dress (and not just of that) form a supplement to the illustrations from The Boxer Codex. This manuscript is also one of the first documents relating to the so-called volumes of costumes, which were put together both in Europe and in the Far East, and which made it possible to learn about still undiscovered countries and their inhabitants.
7
Rawat, Rajneesh, Manik Gedam, Jyoti Baghel, and Shalini Baghel. "A rare association of uterine leiomyoma with mesenteric vein thrombosis and bowel gangrene: case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 4 (March 24, 2021): 1721. http://dx.doi.org/10.18203/2320-1770.ijrcog20211167.
Повний текст джерелаАнотація:
Uterine fibroids are the most common benign pelvic tumors in women. There are many complications reported with fibroids. However, mesenteric vein thrombosis and small bowel gangrene caused by a uterine fibroid are rare. This manuscript reports a rare case of 40 year female with a large uterine fibroid associated with mesenteric vein thrombosis and bowel ischemia. She underwent exploratory laparotomy in which resection of gangrenous bowel including jejunum and ileum was done along with left sided jejunostomy and right sided ileostomy. Total abdominal hysterectomy with bilateral salpingooophorectomy was done followed by jejunoileal anastomosis 6 weeks later. Hence, in patients presenting with acute abdomen and uterine fibroids, bowel gangrene must be included in the differential diagnosis.
8
Bokova, Elizaveta, Wendy Jo Svetanoff, Joseph J. Lopez, Marc A. Levitt, and Rebecca M. Rentea. "State of the Art Bowel Management for Pediatric Colorectal Problems: Anorectal Malformations." Children 10, no. 5 (May 8, 2023): 846. http://dx.doi.org/10.3390/children10050846.
Повний текст джерелаАнотація:
Up to 79% of patients with anorectal malformations (ARMs) experience constipation and/or soiling after a primary posterior sagittal anoplasty (PSARP) and are referred to a bowel management program. We aim to report the recent updates in evaluating and managing these patients as part of the manuscript series on the current bowel management protocols for patients with colorectal diseases (ARMs, Hirschsprung disease, functional constipation, and spinal anomalies). The unique anatomic features of ARM patients, such as maldeveloped sphincter complex, impaired anal sensation, and associated spine and sacrum anomalies, indicate their bowel management plan. The evaluation includes an examination under anesthesia and a contrast study to exclude anatomic causes of poor bowel function. The potential for bowel control is discussed with the families based on the ARM index calculated from the quality of the spine and sacrum. The bowel management options include laxatives, rectal enemas, transanal irrigations, and antegrade continence enemas. In ARM patients, stool softeners should be avoided as they can worsen soiling.
9
López Ruiz, María del Carmen. "David Hamidovič, Claire Clivaz, Sarah Bowen Savant (eds.), in coll. with Alessandra Marguerat, Ancient Manuscripts in Digital Culture. Visualization, Data Mining, Communication, Brill, Leiden–Boston 2019 (Digital Biblical Studies, 3), PP. XVI + 28." Mediterranea. International Journal on the Transfer of Knowledge 6 (March 31, 2021): 357–60. http://dx.doi.org/10.21071/mijtk.v6i.13012.
Повний текст джерелаАнотація:
Review of:
David Hamidovič, Claire Clivaz, Sarah Bowen Savant (eds.), in coll. with Alessandra Marguerat, Ancient Manuscripts in Digital Culture. Visualization, Data Mining, Communication, Brill, Leiden–Boston 2019 (Digital Biblical Studies, 3), PP. XVI + 28
10
Nair, Jayasree, and Akhil Maheshwari. "Non-coding RNAs in Necrotizing Enterocolitis- A New Frontier?" Current Pediatric Reviews 18, no. 1 (February 2022): 25–32. http://dx.doi.org/10.2174/1573396317666211102093646.
Повний текст джерелаАнотація:
Abstract: With the recognition that only 2% of the human genome encodes for a protein, a large part of the “non-coding” portion is now being evaluated for a regulatory role in cellular processes. These non-coding RNAs (ncRNAs) are subdivided based on the size of the nucleotide transcript into microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), but most of our attention has been focused on the role of microRNAs (miRNAs) in human health and disease. Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis affecting preterm infants, has a multifactorial, unclear etiopathogenesis, and we have no specific biomarkers for diagnosis or the impact of directed therapies. The information on ncRNAs, in general, and particularly in NEC, is limited. Increasing information from other inflammatory bowel disorders suggests that these transcripts may play an important role in intestinal inflammation. Here, we review ncRNAs for definitions, classifications, and possible roles in prematurity and NEC using some preliminary information from our studies and from an extensive literature search in multiple databases including PubMed, EMBASE, and Science Direct. miRNAs will be described in another manuscript in this series, hence in this manuscript we mainly focus on lncRNAs.
11
Gimeno-García, Antonio Z., Federica Benítez-Zafra, David Nicolás-Pérez, and Manuel Hernández-Guerra. "Colon Bowel Preparation in the Era of Artificial Intelligence: Is There Potential for Enhancing Colon Bowel Cleansing?" Medicina 59, no. 10 (October 15, 2023): 1834. http://dx.doi.org/10.3390/medicina59101834.
Повний текст джерелаАнотація:
Background and Objectives: Proper bowel preparation is of paramount importance for enhancing adenoma detection rates and reducing postcolonoscopic colorectal cancer risk. Despite recommendations from gastroenterology societies regarding the optimal rates of successful bowel preparation, these guidelines are frequently unmet. Various approaches have been employed to enhance the rates of successful bowel preparation, yet the quality of cleansing remains suboptimal. Intensive bowel preparation techniques, supplementary administration of bowel solutions, and educational interventions aimed at improving patient adherence to instructions have been commonly utilized, particularly among patients at a high risk of inadequate bowel preparation. Expedited strategies conducted on the same day as the procedure have also been endorsed by scientific organizations. More recently, the utilization of artificial intelligence (AI) has emerged for the preprocedural detection of inadequate bowel preparation, holding the potential to guide the preparation process immediately preceding colonoscopy. This manuscript comprehensively reviews the current strategies employed to optimize bowel cleansing, with a specific focus on patients with elevated risks for inadequate bowel preparation. Additionally, the prospective role of AI in this context is thoroughly examined. Conclusions: While a majority of outpatients may achieve cleanliness with standard cleansing protocols, dealing with hard-to-prepare patients remains a challenge. Rescue strategies based on AI are promising, but such evidence remains limited. To ensure proper bowel cleansing, a combination of strategies should be performed.
12
Alexander, Karen M., Sherwin S. Chan, Erin Opfer, Alain Cuna, Jason D. Fraser, Shazia Sharif, and Minesh Khashu. "Implementation of bowel ultrasound practice for the diagnosis and management of necrotising enterocolitis." Archives of Disease in Childhood - Fetal and Neonatal Edition 106, no. 1 (May 12, 2020): 96–103. http://dx.doi.org/10.1136/archdischild-2019-318382.
Повний текст джерелаАнотація:
Necrotising enterocolitis (NEC) is a serious inflammatory bowel disease of prematurity with potentially devastating complications and remains a leading cause of morbidity and mortality among premature infants. In recent years, there has been accumulating data regarding benefits of using bowel ultrasound (BUS) in the diagnosis and management of NEC. Despite this, adoption of robust BUS programmes into clinical practice has been slow. As BUS is a relatively new technique, many barriers to implementation exist, namely lack of education and training for sonographers and radiologists, low case volume and unfamiliarity by clinicians regarding how to use the information provided. The aim of this manuscript is to provide a framework and a roadmap for units to implement BUS in day-to-day practice for NEC diagnosis and management.
13
VAN DE VEN, HANS. "Robert Hart and Gustav Detring during the Boxer Rebellion." Modern Asian Studies 40, no. 3 (July 2006): 631–62. http://dx.doi.org/10.1017/s0026749x06002058.
Повний текст джерелаАнотація:
This article focuses on Robert Hart during the Boxer Rebellion. My reconstruction of his activities is based on a recently discovered file in the archives of the Chinese Maritime Customs Service held at the Second Historical Archives in Nanjing. While it has long been known that Hart corresponded with Qing officials during the Siege itself and while a few letters have been published, the file contains more than one hundred exchanges between Hart and Qing officials written after the end of the Siege of the Legations. I have further relied on a box of documents dealing with the Boxer Rebellion in the Hart Manuscript Collection at the Queen's University of Belfast, including Hart's notes on his meetings with Qing officials. These materials provide insight into the way Hart was able to persuade the Qing and foreign countries to begin negotiations and illustrate the critical role he played in fashioning the Boxer Protocol signed on 7 September 1901.
14
CROSSLEY, JOHN N. "The Early History of the Boxer Codex." Journal of the Royal Asiatic Society of Great Britain & Ireland 24, no. 1 (September 4, 2013): 115–24. http://dx.doi.org/10.1017/s1356186313000552.
Повний текст джерелаАнотація:
AbstractIn 1950 this journal published Charles Boxer's description of the Codex that bears his name and is now in the Lilly Library in Bloomington, Indiana. In this article I shed light on a number of questions about the volume that he left unanswered. The plan of the essay is as follows. First, I recapitulate the nature, composition and contents of the Codex, and its associations with Chinese artists. Next, I turn to evidence that the explorer Quíros saw the manuscript in the court in Madrid no later than 1610; in particular I compare the text of his Summary relation with part of the Boxer Codex. Finally, an examination of the binding shows the Codex was only bound in Madrid, strongly suggesting how and when it got to Spain.
15
Krajewski, Piotr K., Maria Tsoukas, and Jacek C. Szepietowski. "Pathological and Therapeutical Implications of Pyroptosis in Psoriasis and Hidradenitis Suppurativa: A Narrative Review." Current Issues in Molecular Biology 46, no. 1 (January 11, 2024): 663–76. http://dx.doi.org/10.3390/cimb46010043.
Повний текст джерелаАнотація:
This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic pathways involving the unbalanced interaction between the adaptive and innate immune systems. This review focuses on the molecular changes in psoriatic and HS skin, emphasizing the activation of dendritic cells, secretion of interleukins (IL-17, IL-22, and TNF-α), and the involvement of inflammasomes, particularly NLRP3. This manuscript discusses the role of caspases, especially caspase-1, in driving pyroptosis and highlights the family of gasdermins (GSDMs) as key players in the formation of pores leading to cell rupture and the release of proinflammatory signals. This study delves into the potential therapeutic implications of targeting pyroptosis in psoriasis and HS, examining existing medications like biologics and Janus kinase inhibitors. It also reviews the current limitations and challenges in developing therapies that selectively target pyroptosis. Additionally, the manuscript explores the role of pyroptosis in various inflammatory disorders associated with psoriasis and HS, such as inflammatory bowel disease, diabetes mellitus, and cardiovascular disorders. The review concludes by emphasizing the need for further research to fully elucidate the pathomechanisms of these dermatoses and develop effective, targeted therapies.
16
KOTZE, Lorete Maria da Silva, Paulo Gustavo KOTZE, Luiz Roberto KOTZE, and Renato NISIHARA. "MICROSCOPIC COLITIS: CONSIDERATIONS FOR GASTROENTEROLOGISTS, ENDOSCOPISTS, AND PATHOLOGISTS." Arquivos de Gastroenterologia 60, no. 2 (June 2023): 188–93. http://dx.doi.org/10.1590/s0004-2803.20230222-143.
Повний текст джерелаАнотація:
ABSTRACT Microscopic colitis is a chronic inflammatory bowel disease characterized by non-bloody diarrhea that can range from mild to severe. It is difficult to attribute up to 10-20% of chronic diarrhea to microscopic colitis. The three determinants factors of the diagnosis are characteristic clinical symptoms, normal endoscopic picture of the colon, and pathognomonic histological picture. This manuscript aimed to update considerations and recommendations for professionals involved (gastroenterologist, endoscopists and pathologist) in the diagnosis of MC. In addition, a short recommendation about treatment.
17
Zareshahrabadi, Zahra, Mojtaba Shafiekhani, Hamed Nikoupour, Hasti Nouraei, Hamid Morovati, and Kamiar Zomorodian. "Emerging of Fatal Colitis with Multidrug-Resistant Candida glabrata after Small Bowel Transplantation." Case Reports in Transplantation 2021 (September 9, 2021): 1–6. http://dx.doi.org/10.1155/2021/9995583.
Повний текст джерелаАнотація:
Background. Small bowel transplantation is a potential option for patients with intestinal-failure, and the incidences of infections caused by Candida species that are more resistant to antifungal drugs are increasing in these patients. In this manuscript, we reported a case of fatal colitis after small bowel transplantation induces by multidrug-resistant (MDR) Candida glabrata. Case Presentation. A 52-year-old man has undergone an extensive small bowel resection with the length of the remaining bowel which was less than 40 cm who became a candidate for transplantation. Four months after transplantation, the patient experienced severe bloody diarrhea with abdominal distension. Ileoscopy and colonoscopy did not show neither pathological change and rejection nor cytomegalovirus (CMV) infection posttransplantation. Abdomen computed tomography showed diffuse moderate small bowel wall thickening. After detection of budding yeast in the stool samples, stool culture was positive for Candida, DNA was extracted, and ITS1-5.8s-ITS2 region of the fungal agent was amplified. Sequencing analysis of PCR and antifungal susceptibility testing revealed that this isolate was multidrug-resistant C. glabrata. Besides, there was no evidence for other pathogens known to cause infection in various laboratory tests. Immediate antifungal treatments with caspofungin remained unsuccessful, and on the eighteenth day of admission, the patient expires with septic shock. Conclusion. These findings highlight the challenging management of candidiasis in patients with small bowel transplantation. Infectious diseases due to MDR organisms have emerged as a vital clinical problem in this patient population.
18
Zarco Arreola, Karla I., and Guadalupe G. Yañez Herrera. "Gallstone ileus an uncommon cause of bowel obstruction." International Journal of Research in Medical Sciences 10, no. 8 (July 27, 2022): 1759. http://dx.doi.org/10.18203/2320-6012.ijrms20221990.
Повний текст джерелаАнотація:
Gallstone ileus is caused by the impaction of one or more gallstones within the gastrointestinal tract leading to mechanical obstruction. Thomas Bartholin described the first case in 1654 during an autopsy. This manuscript describes a case of gallstone ileus in a 39-year-old woman who presented data of intestinal occlusion and hemodynamic instability, being managed with intestinal resection for a 7 cm stone and entero-entero anastomosis, achieving an adequate post-surgical evolution. It is a rare complication of cholelithiasis and is found in 2 to 3% of all cases associated with recurrent episodes of cholecystitis, it occurs predominantly in women. In elderly patients (>65 years) it accounts for 25% of all cases of small bowel obstruction and carries a fivefold increased risk of morbidity (20 to 57%) compared to other causes of small bowel obstruction.
19
Tefas, Cristian, and Marcel Tanțău. "Clinical Applications of Raman Spectroscopy in Inflammatory Bowel Diseases. A Review." Journal of Gastrointestinal and Liver Diseases 27, no. 4 (December 31, 2018): 433–38. http://dx.doi.org/10.15403/jgld.2014.1121.274.app.
Повний текст джерелаАнотація:
Background & Aims: Inflammatory bowel diseases are still difficult to diagnose and differentiate in some cases despite the serological, imaging, endoscopic and histopathological armamentarium. Raman spectroscopy is a technique that could help with these shortcomings. The aim of this paper is to present the accuracy of Raman spectroscopy in the diagnosis and monitoring of patients with inflammatory bowel diseases.Methods: We identified the published manuscripts and abstracts up to the 31st of December 2017 by a systematic search of Medline, Embase, Cochrane and other trial registries.Results: Eight publications were found, showing sensitivities and specificities of Raman spectroscopy in diagnosing and differentiating inflammatory bowel diseases ranging from 82 to 99% and 57 to 99%, respectively, and accuracies of up to 95%.Conclusion: The technique has so far proven its potential in the positive and differential diagnosis of Crohn’s disease or ulcerative colitis, allowing for very rapid results with high sensitivity and specificity.
20
Timm, Torsten, and Andreas Schinner. "Review of The linguistics of the Voynich manuscript by Claire Bowern and Luke Lindemann." Cryptologia 45, no. 5 (May 7, 2021): 434–38. http://dx.doi.org/10.1080/01611194.2021.1911875.
Повний текст джерела
21
Bagley, Carlos A., and Ziya L. Gokaslan. "Cauda equina syndrome caused by primary and metastatic neoplasms." Neurosurgical Focus 16, no. 6 (June 2004): 1–18. http://dx.doi.org/10.3171/foc.2004.16.6.3.
Повний текст джерелаАнотація:
Cauda equina syndrome (CES) is defined as the constellation of symptoms that includes low-back pain, sciatica, saddle anesthesia, decreased rectal tone and perineal reflexes, bowel and bladder dysfunction, and variable amounts of lower-extremity weakness. There are several causes of this syndrome including trauma, central disc protrusion, hemorrhage, and neoplastic invasion. In this manuscript the authors reviewed CES in the setting of both primary and secondary neoplasms. They examined the various primary tumor types in this region as well as those representative of metastatic spread. Both surgical and nonsurgical management in this setting were studied.
22
Jeep, John M. "The Fables of Ulrich Bonerius (ca. 1350): Masterwork of Late Medieval Didactic Literature. Translated by Albrecht Classen. Newcastle Upon Tyne, Cambridge Scholars Publishing, 2020, XXXII, 264 pp., 4 unpaginated colors illustrations between pp. 106/107." Mediaevistik 34, no. 1 (January 1, 2021): 466–68. http://dx.doi.org/10.3726/med.2021.01.117.
Повний текст джерелаАнотація:
Abstract: This very welcome, first translation of the one-hundred fables (with preface and afterword) by Ulrich Bonerius – known in German as Boner – represents a noteworthy contribution to English language medieval studies. Bonerius called his collection Edelstein (‘gemstone’), the meaning of which is explained in his Preface and exemplified in the first, well-known fable, where a rooster fails to identify and hence is unable to appreciate the precious object. In addition to five color illustrations from the Heidelberg University Library, Cod. Pal. germ. 794, Classen has provided 10 black and white images from the same fine manuscript, and one personal photograph (to illustrate fable no. 83, “Of an Oak Tree and a Reed”). The apparent lack of interest in Bonerius in the English-speaking world can be illustrated by the fact that there are merely eight entries in the MLA International Bibliography (search: Ulrich Boner, or his Edelstein; Bonerius yielded no entries; accessed Jan. 7, 2022).
23
Bokova, Elizaveta, Ninad Prasade, John M. Rosen, Irene Isabel P. Lim, Marc A. Levitt, and Rebecca M. Rentea. "State of the Art Bowel Management for Pediatric Colorectal Problems: Spinal Anomalies." Children 10, no. 9 (September 15, 2023): 1558. http://dx.doi.org/10.3390/children10091558.
Повний текст джерелаАнотація:
Background: Patients with spinal abnormalities often struggle with fecal and/or urinary incontinence (up to 87 and 92%, respectively) and require a collaborative approach to bowel management in conjunction. Methods: To define existing approaches and propose state-of-the-art bowel management, a literature search was performed using Medline/PubMed, Google Scholar, Cochrane, and EMBASE databases and focusing on the manuscripts published July 2013 and July 2023. Results: Patients with spinal anomalies have impaired innervation of the rectum and anal canal, decreasing the success rate from laxatives and rectal enemas. Thus, transanal irrigations and antegrade flushes are widely utilized in this group of patients. Based on spinal MRI, the potential for bowel control in these children depends on age, type, and lesion level. On referral for bowel management, a contrast study is performed to assess colonic motility and evacuation of stool, followed by a series of abdominal X-rays to define colonic emptying and adjust the regimen. The options for management include laxatives, rectal enemas, transanal irrigations, antegrade flushes, and the creation of a stoma. Approximately 22–71% of patients achieve social continence dependent on the type and level of the lesion. Conclusion: Patients with spinal anomalies require a thorough assessment for continence potential and stool burden prior to initiation of bowel management. The optimal treatment option is defined according to the patient’s age, anatomy, and mobility. The likelihood of independent bowel regimen administration should be discussed with the patients and their caregivers.
24
Valvano, Marco, Annalisa Capannolo, Nicola Cesaro, Gianpiero Stefanelli, Stefano Fabiani, Sara Frassino, Sabrina Monaco, Marco Magistroni, Angelo Viscido, and Giovanni Latella. "Nutrition, Nutritional Status, Micronutrients Deficiency, and Disease Course of Inflammatory Bowel Disease." Nutrients 15, no. 17 (August 31, 2023): 3824. http://dx.doi.org/10.3390/nu15173824.
Повний текст джерелаАнотація:
During the disease course, most Inflammatory Bowel Disease patients present a condition of malnutrition, undernutrition, or even overnutrition. These conditions are mainly due to suboptimal nutritional intake, alterations in nutrient requirements and metabolism, malabsorption, and excessive gastrointestinal losses. A suboptimal nutritional status and low micronutrient serum levels can have a negative impact on both induction and maintenance of remission and on the quality of life of Inflammatory Bowel Disease patients. We performed a systematic review including all the studies evaluating the connection between nutrition, nutrition status (including undernutrition and overnutrition), micronutrient deficiency, and both disease course and therapeutic response in Inflammatory Bowel Disease patients. This systematic review was performed using PubMed/MEDLINE and Scopus. Four main clinical settings concerning the effect of nutrition on disease course in adult Inflammatory Bowel Disease patients were analyzed (induction of remission, maintenance of remission, risk of surgery, post-operative recurrence, and surgery-related complications). Four authors independently reviewed abstracts and manuscripts for eligibility. 6077 articles were found; 762 duplicated studies were removed. Out of 412 full texts analyzed, 227 were included in the review. The evidence summarized in this review showed that many nutritional aspects could be potential targets to induce a better control of symptoms, a deeper remission, and overall improve the quality of life of Inflammatory Bowel Disease patients.
25
Bettag, Jeffery, Loren Po, Cassius Cunningham, Rahul Tallam, Kento Kurashima, Aakash Nagarapu, Chelsea Hutchinson, et al. "Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome." Nutrients 14, no. 21 (November 4, 2022): 4660. http://dx.doi.org/10.3390/nu14214660.
Повний текст джерелаАнотація:
Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut–brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.
26
Michel, Hilary K., Ross M. Maltz, Brendan Boyle, Amy Donegan, and Jennifer L. Dotson. "Applying Telemedicine to Multidisciplinary Pediatric Inflammatory Bowel Disease Care." Children 8, no. 5 (April 21, 2021): 315. http://dx.doi.org/10.3390/children8050315.
Повний текст джерелаАнотація:
Multidisciplinary care is essential to the delivery of comprehensive, whole-person care for children and adolescents with inflammatory bowel disease (IBD). Team members may include medical, psychosocial, and ancillary providers as well as patient and family advocates. There is significant variability in how this care is delivered from center to center, though prior to the COVID-19 pandemic, most care occurred during in-person visits. At the onset of the pandemic, medical systems world-wide were challenged to continue delivering high quality, comprehensive care, requiring many centers to turn to telemedicine technology. The aim of this manuscript is to describe the process by which we converted our multidisciplinary pediatric and adolescent IBD visits to a telemedicine model by leveraging technology, a multidisciplinary team, and quality improvement (QI) methods. Finally, we put our experience into context by summarizing the literature on telemedicine in IBD care, with a focus on pediatrics and multidisciplinary care.
27
Donesky, Barry W. "The role of laparoscopic ovarian electrocautery in the new millennium." Reproductive Medicine Review 7, no. 2 (July 1999): 111–29. http://dx.doi.org/10.1017/s0962279999000241.
Повний текст джерелаАнотація:
With the introduction of bilateral ovarian wedge resection (BOWR) in 1935, Stein and Leventhal were the first to describe an effective treatment for the chronic anovulation and associated infertility resulting from what was later to become known as polycystic ovary syndrome (PCOS). Since that time, many less invasive methods of ovulation induction and enhancement have been developed. While the success of medical ovulation induction led to the almost complete replacement of BOWR by the late 1970's, the presence of a group of women who are not optimally treated by medical methods has maintained the interest in surgical approaches. Surgical and nonsurgical methods of treatment for anovulatory women have continued to be refined. This manuscript reviews this literature and attempts to provide a framework for the role that modern surgical methods of ovulation induction might play in the current scheme of treatment for anovulatory infertility in women with PCOS.
28
Malter, Lisa B., Amanda Israel, and David T. Rubin. "Proposal to Update the Curriculum in Inflammatory Bowel Diseases for Categorical Gastroenterology Fellows." Inflammatory Bowel Diseases 25, no. 9 (May 22, 2019): 1443–49. http://dx.doi.org/10.1093/ibd/izz107.
Повний текст джерелаАнотація:
Abstract Education in inflammatory bowel disease (IBD) varies widely between categorical gastroenterology (GI) programs and is largely related to the presence of expert clinicians, patient population, and the presence of an IBD center. The treatment of IBD is becoming increasingly complex at a rapid pace, widening this educational divide. This manuscript outlines all the current US educational offerings in IBD for GI fellows, including how to obtain supplemental education during the 3-year training period and beyond. It reviews how to assess trainee knowledge in the field of IBD and proposes 8 clinically anchored, entrustable professional activities that should help prioritize important aspects of IBD management to incorporate during categorical GI training.
29
Li, J., M. Hu, M. A. Scaffidi, N. Gimpaya, R. Bansal, Y. Verma, K. Elsolh, R. Khan, and S. C. Grover. "A104 PREVALENCE OF GHOST-AUTHORSHIP IN INDUSTRY-SPONSORED CLINICAL TRIALS." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (March 1, 2021): 80–81. http://dx.doi.org/10.1093/jcag/gwab002.102.
Повний текст джерелаАнотація:
Abstract Background Ghost-authorship involves the exclusion of individuals who have made substantial contributions to the article from the author byline. Previous studies have found that ghost-authorship is highly prevalent in industry-sponsored clinical trials. Its prevalence, however, has yet to be investigated in trials of biologics in the management of inflammatory bowel disease (IBD). Aims To determine the prevalence of ghost-authorship in IBD biologic industry-sponsored clinical randomized controlled trials (RCTs). Methods Biologic medications indicated for ulcerative colitis (UC) or for Crohn’s disease (CD) were identified using the Food and Drug Agency (FDA) database. We identified the clinical trials on clinicaltrials.gov corresponding to the data presented at the time of FDA approval. Specifically, we included the first publication for each trial to report study results for our analysis. Two authors independently identified the presence of ghost-authorship, which we defined as the exclusion on the author byline of the included RCT publication of any individuals who assisted in the writing of the trial manuscript and/or performed the data analyses. Results We identified a total of 28 relevant RCTs on biologic medications (10 for UC and 18 for CD), which were matched to 20 publications. We found ghost-authorship in 70% of publications (n=14); 40% (n=8) involved manuscript and protocol writing assistance from sponsor staff; 35% (n=7) involved medical writers from external companies; 15% (n=3) involved both sponsor staff and medical writers assisting in manuscript writing; and 20% (n=4) involved individuals performing data analysis or interpretation. Conclusions We found that ghost-authorship in industry-sponsored IBD biologic clinical trials has a moderately high prevalence, with the most common being manuscript or protocol writing assistance. A lack of transparency regarding sponsor-affiliated and/or external contributors may negatively affect the trust placed in medical research. One limitation is that data was only extracted from publications. Further evidence on ghost-authorship may be found in study protocols and registrations, which will be investigated in the future. Funding Agencies None
30
Bokova, Elizaveta, Wendy Jo Svetanoff, Marc Aaron Levitt, and Rebecca Maria Rentea. "Pediatric Bowel Management Options and Organizational Aspects." Children 10, no. 4 (March 28, 2023): 633. http://dx.doi.org/10.3390/children10040633.
Повний текст джерелаАнотація:
A bowel management program (BMP) to treat fecal incontinence and severe constipation is utilized for patients with anorectal malformations, Hirschsprung disease, spinal anomalies, and functional constipation, decreasing the rate of emergency department visits, and hospital admissions. This review is part of a manuscript series and focuses on updates in the use of antegrade flushes for bowel management, as well as organizational aspects, collaborative approach, telemedicine, the importance of family education, and one-year outcomes of the bowel management program. Implementation of a multidisciplinary program involving physicians, nurses, advanced practice providers, coordinators, psychologists, and social workers leads to rapid center growth and enhances surgical referrals. Education of the families is crucial for postoperative outcomes, prevention, and early detection of complications, especially Hirschsprung-associated enterocolitis. Telemedicine can be proposed to patients with a defined anatomy and is associated with high parent satisfaction and decreased patient stress in comparison to in-person visits. The BMP has proved to be effective in all groups of colorectal patients at a 1- and 2-year follow-up with social continence achieved in 70–72% and 78% of patients, respectively, and an improvement in the patients’ quality of life. A transitional care to adult program is essential to maintain the same quality of care, and continuity of care and to achieve desired long-term outcomes as the patient reaches adult age.
31
Oliveira, Diego Brandão, Naiara Salgado Carvalho, Gabriele Alves dos Anjos, and Genoile Oliveira Santana Silva. "PATHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME IN PATIENTS WITH QUIESCENT INFLAMMATORY BOWEL DISEASE." Inflammatory Bowel Diseases 29, Supplement_1 (January 26, 2023): S72. http://dx.doi.org/10.1093/ibd/izac247.137.
Повний текст джерелаАнотація:
Abstract BACKGROUND The presence of symptoms compatible with irritable bowel syndrome (IBS) in patients with inflammatory bowel disease (IBD) in remission is very common, affecting approximately one third of this population, with a negative impact on quality of life. It’s pathophysiology is still unclear, and it may be due to a subclinical inflammatory activity of IBD or a superimposed “true” IBS. Understanding the origin of this condition can help with the management, reducing withdrawals and reducing the chances of mistakes in the therapeutic escalation. AIMS To understand the pathophysiology of IBS manifestations in patients with quiescent IBD. METHODS Narrative literature review, based on relevant scientific publications, systematic reviews and expert opinions when applicable. DISCUSSION Some manuscripts have shown higher levels of fecal calprotectin and TNF-α, supporting the hypothesis that symptoms are due to subclinical activity of IBD. Other data corroborate the theory that the two diseases coexist, such as the higher prevalence in female sex and in patients with mood disorders, even if they are in endoscopic and histologic remission. Contrary to this manichaeism, a third hypothesis emerges with an expanded pathophysiological spectrum, with complementary characteristics of both diseases, considering bowel permeability and differentiated immune activation, with typical cytokines of IBD and IBS, resulting in sensorimotor dysfunction of brain-gut axis. CONCLUSION Based on recent cellular and molecular studies, the hypothesis that unites the pathophysiological processes of the two diseases gains strength, where the intestinal damage caused by IBD, with loss of the epithelial barrier and microinflammation creates a favorable environment for the development of symptoms after symptoms of IBS triggers, such as stress, anxiety, and infections.
32
Wang, S. Keisin, Andres Fajardo, Raghu L. Motaganahalli, and Alok K. Gupta. "Successful Treatment of an Infected Zenith Fenestrated Endograft Without Explantation." Vascular and Endovascular Surgery 52, no. 7 (May 7, 2018): 569–72. http://dx.doi.org/10.1177/1538574418774663.
Повний текст джерелаАнотація:
Current surgical dogma for infected aortic endografts consists of complete explantation concurrent with revascularization via extra-anatomic bypass or in situ infection-resistant conduit. However, this treatment paradigm is associated with high rates of postoperative mortality and major morbidity. Therefore, patients with prohibitive operative risk are often not offered surgical intervention. In the following manuscript, we report the successful treatment of an 85-year-old gentleman with a fenestrated aortic endograft (Cook Medical, Bloomington, Indiana) infected secondary to the formation of an aortoenteric fistula with primary bowel repair, washout, and lifelong antibiotics and followed for nearly 2 years after intervention. Therefore, this nonexplantation approach can be considered for patients who may otherwise have no surgical recourse.
33
Smith, Sadie, and Jill Eckert. "Interventional Pain Management and Female Pelvic Pain: Considerations for Diagnosis and Treatment." Seminars in Reproductive Medicine 36, no. 02 (March 2018): 159–63. http://dx.doi.org/10.1055/s-0038-1676104.
Повний текст джерелаАнотація:
AbstractChronic pelvic pain (CPP) is a recurring and/or constant pain of at least six months duration that has resulted in either functional or psychological disability that can require interventional treatments. Chronic pelvic pain can be visceral, somatic, neuropathic, or a combination. Patients with CPP often suffer from concurrent bowel or bladder dysfunction, sexual dysfunction, depression, and anxiety. The complexity of chronic pelvic pain can be challenging to treat, which can lead to frustration for both patients and their physicians. Treatment should involve a comprehensive and multi-modal approach involving psychosocial support, counseling, physical therapy, medication management, and interventional procedures. This manuscript will focus both on the etiologies and the interventional treatment options for chronic pelvic pain.
34
Guzmán-Mejía, Fabiola, Marycarmen Godínez-Victoria, Daniel Efrain Molotla-Torres, and Maria Elisa Drago-Serrano. "Lactoferrin as a Component of Pharmaceutical Preparations: An Experimental Focus." Pharmaceuticals 16, no. 2 (January 31, 2023): 214. http://dx.doi.org/10.3390/ph16020214.
Повний текст джерелаАнотація:
Lactoferrin is an 80 kDa monomeric glycoprotein that exhibits multitask activities. Lactoferrin properties are of interest in the pharmaceutical field for the design of products with therapeutic potential, including nanoparticles and liposomes, among many others. In antimicrobial preparations, lactoferrin has been included either as a main bioactive component or as an enhancer of the activity and potency of first-line antibiotics. In some proposals based on nanoparticles, lactoferrin has been included in delivery systems to transport and protect drugs from enzymatic degradation in the intestine, favoring the bioavailability for the treatment of inflammatory bowel disease and colon cancer. Moreover, nanoparticles loaded with lactoferrin have been formulated as delivery systems to transport drugs for neurodegenerative diseases, which cannot cross the blood–brain barrier to enter the central nervous system. This manuscript is focused on pharmaceutical products either containing lactoferrin as the bioactive component or formulated with lactoferrin as the carrier considering its interaction with receptors expressed in tissues as targets of drugs delivered via parenteral or mucosal administration. We hope that this manuscript provides insights about the therapeutic possibilities of pharmaceutical Lf preparations with a sustainable approach that contributes to decreasing the resistance of antimicrobials and enhancing the bioavailability of first-line drugs for intestinal chronic inflammation and neurodegenerative diseases.
35
Kovacs, David. "PINDAR AS LAVDATOR EQVORVM IN HORACE, CARMINA 4.2.17–20 AND ARS POETICA 83–5." Classical Quarterly 67, no. 2 (October 12, 2017): 659–62. http://dx.doi.org/10.1017/s0009838817000635.
Повний текст джерелаАнотація:
At Carm. (Odes) 4.2.17–20 Horace's catalogue of Pindar's poetry reaches his victory odes:siue quos Elea domum reducitpalma caelestis pugilemue equumuedicit et centum potiore signismunere donat; 20The text, transmitted without variants in our manuscripts, means ‘(Pindar deserves the laurel wreath whether he writes bold dithyrambs or sings of gods and heroes) or tells of those escorted home as gods by the Elean palm-branch, whether boxer or horse, and bestows on them a gift more valuable than a hundred statues’. The two italicized expressions are more difficult than the commentators seem willing to admit. I discuss them separately.
36
Bokova, Elizaveta, Ninad Prasade, Sanjana Janumpally, John M. Rosen, Irene Isabel P. Lim, Marc A. Levitt, and Rebecca M. Rentea. "State of the Art Bowel Management for Pediatric Colorectal Problems: Hirschsprung Disease." Children 10, no. 8 (August 20, 2023): 1418. http://dx.doi.org/10.3390/children10081418.
Повний текст джерелаАнотація:
After an initial pull-though, patients with Hirschsprung disease (HD) can present with obstructive symptoms, Hirschsprung-associated enterocolitis (HAEC), failure to thrive, or fecal soiling. This current review focuses on algorithms for evaluation and treatment in children with HD as a part of a manuscript series on updates in bowel management. In constipated patients, anatomic causes of obstruction should be excluded. Once anatomy is confirmed to be normal, laxatives, fiber, osmotic laxatives, or mechanical management can be utilized. Botulinum toxin injections are performed in all patients with HD before age five because of the nonrelaxing sphincters that they learn to overcome with increased age. Children with a patulous anus due to iatrogenic damage of the anal sphincters are offered sphincter reconstruction. Hypermotility is managed with antidiarrheals and small-volume enemas. Family education is crucial for the early detection of HAEC and for performing at-home rectal irrigations.
37
Usai-Satta, Paolo, Mariantonia Lai, and Francesco Oppia. "Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence." Nutrients 14, no. 3 (January 28, 2022): 584. http://dx.doi.org/10.3390/nu14030584.
Повний текст джерелаАнотація:
Background. Lactose malabsorption (LM) is a frequent clinical problem associated with several digestive and extra-digestive diseases. The aim of this manuscript was to clarify the real clinical impact of LM on these disorders. Methods. A literature search for digestive and extra-digestive disorders related to LM was carried out using PubMed, Medline and Cochrane. Results. A transient lactase deficiency is present in celiac disease (CD) on a normal diet. The persistence of symptoms in CD on a gluten-free diet may be instead, in part, attributed to a primary LM. Similar circumstances are present in inflammatory bowel diseases (IBD), in which LM can be responsible for a part of persistent symptoms in IBD on clinical remission. LM and irritable bowel syndrome (IBS) are instead independent conditions. On the other hand, a lactose-restricted diet may be useful for some IBS patients. A reduced lactose intake can lead to low bone mass and limited risk of fragility fractures. Finally, the absorption of levothyroxine could be conditioned by LM. Conclusions. LM can be responsible for persistent symptoms in CD and IBD. The association with IBS seems to be casual. Bone mass and levothyroxine absorption can be affected by LM.
38
Tempel, David G., Daniel S. Balk, Jesse M. Schafer, and Beatrice Hoffmann. "A brief review of diagnostic properties of point-of-care ultrasound for adult bowel intussusception: Making the case for ultrasound." Journal of Ultrasonography 23, no. 93 (April 28, 2023): 90–96. http://dx.doi.org/10.15557/jou.2023.0016.
Повний текст джерелаАнотація:
Undifferentiated abdominal pain in adults is a common chief complaint in acute care clinics and emergency departments worldwide, representing up to 10% of visits to emergency departments. Many patients have a non-specific presentation and an initial workup with labwork, urine analysis or X-ray might not reveal a specific diagnosis. Although bowel intussusception is a primarily pediatric disease, adult intussusception is a recognized but rare cause of bowel obstruction often requiring surgical intervention. However, recent data from advanced multi-detector computed tomography imaging shows that milder or recurring cases in adults have been underrecognized. Multi-detector computed tomography is still the imaging gold standard for detecting intussusception in adults, but new data showed that sonographers with basic training using the point-of-care ultrasound approach have a reasonable accuracy in detecting this pathology. As the point-of-care ultrasound for undifferentiated abdominal pain is an emerging core skill in the acute care setting, knowledge of sonographic signs of intestinal intussusception should be included in the skill set of physicians. Sonographic findings in adults mimic pediatric cases, but different location patterns and higher malignancy rates exist in adults. In this manuscript, we will review the current literature on adult intussusception and summarize key knowledge of intestinal intussusception in adults. We will present four adult patients diagnosed with different types of adult acute bowel intussusception using the point-of-care ultrasound and describe a focused scanning approach with typical sonographic findings.
39
Sinopoulou, Vassiliki, Morris Gordon, Gordon William Moran, Abdullah Mohammed Abousaleh ma Egiz, Sanjana Phlananthachai, Aditi Rane, and Ahmed Hussein Ali Al-Tameemi. "Prepublication abstract-only reports compared with full-text manuscripts for randomised controlled trials in inflammatory bowel disease: a systematic review." BMJ Open Gastroenterology 11, no. 1 (March 2024): e001334. http://dx.doi.org/10.1136/bmjgast-2023-001334.
Повний текст джерелаАнотація:
IntroductionRandomised controlled trials (RCTs) of key therapies in inflammatory bowel disease (IBD) are often presented and available as abstracts for significant periods of time prior to full publication, often being employed to make strategic and clinical prescribing decisions. We compared the concordance of prepublication abstract-only reports and their respective full-text manuscripts.MethodsPairs of full-text manuscripts and their respective prepublication abstract-only reports for the same RCT outcomes, at the same time point of analysis were included. The RCTs were on treatments for IBD with full-text manuscripts published between 2010 and 2023.ResultsWe found 77 pairs of full-text manuscripts and their prepublication abstract-only reports. There were significant mismatches in the reporting of stated planned outcomes (65/77 matched, p<0.001) and primary outcomes reported in their results sections (67/77, p<0.001); trial registrations (34/65, p<0.001); the number of randomised participants (49/77, p=0.18); participants reaching end of study (21/71, p<0.001) and primary outcome data (40/73, p<0.001). Authors conclusions matched (75/77, p=0.157). Authors did not provide explicit or implied justifications for the absence or non-concordance for any of the above items.ConclusionsAbstract-only reports have consistent issues with both limited reporting of key information and significant differences in data when compared with their later full-text publications. These are not related to further recruitment of patients or word count limitations and are never explained. As abstracts are often used in guidelines, reviews and stakeholder decision-making on prescribing, caution in their use is strongly suggested. Further work is needed to enhance minimum reporting standards in abstract-only works and ensure consistency with final published papers.
40
Ramesh, Gautam, Dana Gerstbacher, Jenna Arruda, Brenda Golianu, John Mark, and Ann Yeh. "Pediatric Integrative Medicine in Academia: Stanford Children’s Experience." Children 5, no. 12 (December 12, 2018): 168. http://dx.doi.org/10.3390/children5120168.
Повний текст джерелаАнотація:
Pediatric integrative medicine is an emerging field which, to date, has not been described in detail in academic medical centers in the United States. Early research of pediatric integrative medicine modalities shows promise for the treatment of common pediatric conditions such as irritable bowel syndrome, acute and chronic pain, headache, and allergy, among others. In light of the growing prevalence of pediatric illnesses and patient complexity, it is crucial to emphasize the patient’s overall well-being. As academic centers around the world start to develop pediatric integrative medicine programs, the aim of this manuscript is to briefly highlight evidence of effective integrative treatments in pediatric subspecialties, to describe the establishment of our integrative medicine program, to summarize its early efforts, and to discuss potential barriers and keys to success.
41
Storck, Lena J., Reinhard Imoberdorf, and Peter E. Ballmer. "Nutrition in Gastrointestinal Disease: Liver, Pancreatic, and Inflammatory Bowel Disease." Journal of Clinical Medicine 8, no. 8 (July 25, 2019): 1098. http://dx.doi.org/10.3390/jcm8081098.
Повний текст джерелаАнотація:
Liver, pancreatic, and inflammatory bowel diseases are often associated with nutritional difficulties and necessitate an adequate nutritional therapy in order to support the medical treatment. As most patients with non-alcoholic fatty liver disease are overweight or obese, guidelines recommend weight loss and physical activity to improve liver enzymes and avoid liver cirrhosis. In contrast, patients with alcoholic steatohepatitis or liver cirrhosis have a substantial risk for protein depletion, trace elements deficiency, and thus malnutrition. Patients with chronic pancreatitis and patients with inflammatory bowel disease have a similar risk for malnutrition. Therefore, it clearly is important to screen these patients for malnutrition with established tools and initiate adequate nutritional therapy. If energy and protein intake are insufficient with regular meals, oral nutritional supplements or artificial nutrition, i.e., tube feeding or parenteral nutrition, should be used to avoid or treat malnutrition. However, the oral route should be preferred over enteral or parenteral nutrition. Acute liver failure and acute pancreatitis are emergencies, which require close monitoring for the treatment of metabolic disturbances. In most patients, energy and protein requirements are increased. In acute pancreatitis, the former recommendation of fasting is obsolete. Each disease is discussed in this manuscript and special recommendations are given according to the pathophysiology and clinical routine.
42
Bhat, Shubha, Toni Zahorian, Regine Robert, and Francis A. Farraye. "Advocating for Patients With Inflammatory Bowel Disease: How to Navigate the Prior Authorization Process." Inflammatory Bowel Diseases 25, no. 10 (February 8, 2019): 1621–28. http://dx.doi.org/10.1093/ibd/izz013.
Повний текст джерелаАнотація:
Abstract In an effort to manage health care costs and avoid improper medication use, prior authorizations (PAs) have become a standard stipulation required by payers in the determination of medication coverage. For gastroenterologists managing patients, especially those with inflammatory bowel disease (IBD), the PA process is time-consuming and further complicated by 2 additional factors: step therapy requirements and failure of payers to recognize updated IBD treatment pathways. These factors often lead to PA denials and cause treatment delays, which in turn can lead to disease progression, ongoing patient suffering, and ultimately an increase in both direct and indirect total costs. In this manuscript, the PA process, PA models, tips and available resources to navigate the PA process, and future advocacy efforts are discussed with the intent to help gastroenterology practices optimize PA outcomes and improve the care provided to patients with IBD and other gastrointestinal disorders.
43
Gálvez, Marisol, Angel Zarate, Hector Espino, Fátima Higuera-de la Tijera, Richard Awad, and Santiago Camacho. "A short telephone-call reminder improves bowel preparation, quality indicators and patient satisfaction with first colonoscopy." Endoscopy International Open 05, no. 12 (November 21, 2017): E1172—E1178. http://dx.doi.org/10.1055/s-0043-117954.
Повний текст джерелаАнотація:
Abstract Background and study aims Addition of a reminder program to conventional indications improves colonoscopy. The aim of this study was to evaluate the effectiveness of a short telephone call reminder (STCR) on a patient’s first colonoscopy. Patients and methods One day before colonoscopy, we made a STCR of < 10 minutes to 141 randomly selected patients of 258 recruited. The STCRs informed patients about the procedure date, indications for taking laxatives, and dietetic requirements. Questions were clarified only when patients asked directly. We evaluated bowel preparation, quality indicators, and patient satisfaction. Data were expressed as mean ± SD and percentages. Statistical differences were evaluated by Student’s t and Chi squared tests; alpha = 0.05. All authors had access to the study data and reviewed and approved the final manuscript. Results The STCR group had better bowel preparation which was demonstrated by higher completion frequency (97.16 % vs. 82.05 %), in less time (4.52 ± 3.06 vs. 5.38 ± 3.03 hours) intake of laxative, and higher Boston’s scale (7.66 ± 2.42 vs. 5.2 ± 1.65). Quality indicators of colonoscopy were better in patients that received a STCR [cecal intubation rate: 100.00 % vs. 87.18 %; polyp detection: 42.55 % vs. 9.4 %; and cecal arrival time (min): 12.09 ± 3.62 vs. 15.09 ± 5.02]. STCR patients were more satisfied (97.87 % vs. 55.56 %) and would repeat colonoscopy (21.99 % vs. 11.11 %). Conclusions A simple additional step such as a STCR improves quality of bowel preparation, quality indicators, and satisfaction of patients undergoing their first colonoscopy. Clinical trial registry in Mexico City General Hospital: DI/16/107/3/108.
44
García Fernández, Roberto Eduardo. "El <em>sūtra</em> budista <em>Mahāmāyūrīvidyārājñī</em> en el <em>Manuscrito Bower</em>." Estudios de Asia y África 57, no. 3 (July 29, 2022): 657–76. http://dx.doi.org/10.24201/eaa.v57i3.2736.
Повний текст джерелаАнотація:
Se ofrece la primera traducción al castellano de la sección VI del Manuscrito Bower, una colección en sánscrito de los siglos IV a VI que incluye obras de medicina, adivinación y protección. La sección presentada contiene una de las versiones más antiguas del texto budista de principios de la era común conocido como Mahāmāyūrīvidyārājñīsūtra, El sūtra de la Reina de los Encantamientos, la Grandiosa Pava Real. Esta obra sintetiza distintos textos apotropaicos budistas, enmarcados en una narrativa de protección contra el veneno de las serpientes y coronados por una fórmula de poder, una dhāraṇī, presentada como instrumento sonoro capaz de ejercer control sobre distintos tipos de seres. En conjunto, es un ejemplo del interés de los budistas por afirmar su soberanía, no solamente sobre los ámbitos del conocimiento y la liberación, sino también sobre las potencias del mundo en su conjunto.
45
Garfinkle, Richard, Carmen G. Loiselle, Jason Park, Julio F. Fiore Jr, Liliana G. Bordeianou, A. Sender Liberman, Nancy Morin, et al. "Development and evaluation of a patient-centred program for low anterior resection syndrome: protocol for a randomized controlled trial." BMJ Open 10, no. 5 (May 2020): e035587. http://dx.doi.org/10.1136/bmjopen-2019-035587.
Повний текст джерелаАнотація:
IntroductionLow anterior resection syndrome (LARS) is described as disordered bowel function after rectal resection that leads to a detriment in quality of life, and affects the majority of individuals following restorative proctectomy for rectal cancer. The management of LARS includes personalised troubleshooting and effective self-management behaviours. Thus, affected individuals need to be well informed and appropriately engaged in their own LARS management. This manuscript describes the development of a LARS patient-centred programme (LPCP) and the study protocol for its evaluation in a randomised controlled trial.Methods and analysisThis will be a multicentre, randomised, assessor-blind, parallel-groups, pragmatic trial evaluating the impact of an LPCP, consisting of an informational booklet, patient diaries and nurse support, on patient-reported outcomes after restorative proctectomy for rectal cancer. The informational booklet was developed by a multidisciplinary LARS team, and was vetted in a focus group and semistructured interviews involving patients, caregivers, and healthcare professionals. The primary outcome will be global quality of life (QoL), as measured by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire—Core 30 (QLQ-C30), at 6 months after surgery. The treatment effect on global QoL will be modelled using generalised estimating equations. Secondary outcomes include symptom change, patient activation, bowel function measures, emotional distress, knowledge about LARS and satisfaction with the LPCP.Ethics and disseminationThe Research Ethics Committee (REC) at the Integrated Health and Social Services Network for West-Central Montreal (health network responsible for the Jewish General Hospital) is the overseeing REC for all Quebec sites. They have granted ethical approval (MP-05-2019-1628) for all Quebec hospitals (Jewish General Hospital, McGill University Health Center, CHU de Quebec) and have granted full authorisation to begin research at the Jewish General Hospital. Patient recruitment will not begin at the other Quebec sites until inter-institutional contracts are finalised and feasibility/authorisation for research is granted by their respective REC. The results of this study will be presented at national and international conferences, and a manuscript with results will be submitted for publication in a high-impact peer-reviewed journal.Trial registration numberNCT03828318Pre-results.
46
Subramanian, Arunkumar, Afrarahamed Jahabardeen, Tamilanban Thamaraikani, and Chitra Vellapandian. "More on the interplay between gut microbiota, autophagy, and inflammatory bowel disease is needed." World Journal of Gastroenterology 30, no. 27 (July 21, 2024): 3356–60. http://dx.doi.org/10.3748/wjg.v30.i27.3356.
Повний текст джерелаАнотація:
The concept of inflammatory bowel disease (IBD), which encompasses Crohn’s disease and ulcerative colitis, represents a complex and growing global health concern resulting from a multifactorial etiology. Both dysfunctional autophagy and dysbiosis contribute to IBD, with their combined effects exacerbating the related inflammatory condition. As a result, the existing interconnection between gut microbiota, autophagy, and the host’s immune system is a decisive factor in the occurrence of IBD. The factors that influence the gut microbiota and their impact are another important point in this regard. Based on this initial perspective, this manuscript briefly highlighted the intricate interplay between the gut microbiota, autophagy, and IBD pathogenesis. In addition, it also addressed the potential targeting of the microbiota and modulating autophagic pathways for IBD therapy and proposed suggestions for future research within a more specific and expanded context. Further studies are warranted to explore restoring microbial balance and regulating autophagy mechanisms, which may offer new therapeutic avenues for IBD management and to delve into personalized treatment to alleviate the related burden.
47
Zarubina, E. D. "A term “minyan” in Venetian Hevrat Shomerim la-Boker minute book (16–17th centuries)." Orientalistica 3, no. 5 (December 29, 2020): 1269–79. http://dx.doi.org/10.31696/2618-7043-2020-3-5-1269-1279.
Повний текст джерелаАнотація:
Research on the early modern Italian Jewish communities shows that this period witnessed a decline of rabbinic authority. From our point of view, one of the signs of this process is the widened scope of situations in which terms previously bound mostly to ritual contexts appear. The article deals with the usage and meaning of the term “minyan” (a quorum of ten men who have reached the age of the religious adulthood necessary for public liturgy) in the first part of the Hevrat Shomerim la-Boker minute book manuscript. Hevrat Shomerim la-Boker is one of the voluntary communal associations of the Venetian Jewish community that was active in the 16–17th centuries. The article examines textual contexts from both chapter and dated notes that contain the term as well as the broader historical context in which these formulae exist. In the first part of the minute book, the term is mentioned five times, three times at the dated notes, two times in the chapter. The analysis of the usage contexts of the term “minyan” revealed that this meaning starts to appear at a wider scope, namely, in administrative contexts. The term also became a part of an idiom that the compiler of the dated notes or scribe used to highlight that a certain procedure was carried out according to the procedural norm and its results are legitimate and accurate.
48
Lebedinski, Ester. "The travels of a tune: Purcell’s ‘If love’s a sweet passion’ and the cultural translation of 17th-century English music." Early Music 48, no. 1 (February 2020): 75–90. http://dx.doi.org/10.1093/em/caaa003.
Повний текст джерелаАнотація:
Abstract The travels of a tune: Purcell’s ‘If love’s a sweet passion’ and the cultural translation of 17th-century English music This article discusses Henry Purcell’s theatre song ‘If love’s a sweet passion’ (from The Fairy Queen, 1692) and its journey into various contexts in England and abroad. The article analyses the song’s appearance in printed songbooks, broadside ballads and single-sheet engravings, and in the Dutch manuscript songbook Finspång 9096:7 (now in Norrköping, Sweden), to show how the song was adapted to various contexts and conventions. The appearance of ‘If love’s a sweet passion’ in Finspång 9096:7 further suggests that there was greater reciprocity in the exchanges between England and continental Europe than hitherto thought. I nuance this claim by arguing that such exchanges were dependent on translation and mediation by musicians such as John Abell (1653–after 1716) or translators such as Abel Boyer (?1667–1729). Boyer used ‘If love’s a sweet passion’ in his Compleat French-Master (1694) and his French lyrics appear in Finspång 9096:7. The article shows the variety of uses and adaptations of ‘If love’s a sweet passion’ in English and French-language contexts. This both challenges notions of ‘elite’ and ‘popular’ music as entirely separate, and invites scholars and performers to imagine Purcell’s theatre songs performed and consumed in new ways.
49
Terraza-Aguirre, Claudia, Mauricio Campos-Mora, Roberto Elizondo-Vega, Rafael A. Contreras-López, Patricia Luz-Crawford, Christian Jorgensen, and Farida Djouad. "Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells." Cells 9, no. 7 (July 10, 2020): 1660. http://dx.doi.org/10.3390/cells9071660.
Повний текст джерелаАнотація:
Mesenchymal stem cells (MSCs) exhibit potent immunoregulatory abilities by interacting with cells of the adaptive and innate immune system. In vitro, MSCs inhibit the differentiation of T cells into T helper 17 (Th17) cells and repress their proliferation. In vivo, the administration of MSCs to treat various experimental inflammatory and autoimmune diseases, such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, and bowel disease showed promising therapeutic results. These therapeutic properties mediated by MSCs are associated with an attenuated immune response characterized by a reduced frequency of Th17 cells and the generation of regulatory T cells. In this manuscript, we review how MSC and Th17 cells interact, communicate, and exchange information through different ways such as cell-to-cell contact, secretion of soluble factors, and organelle transfer. Moreover, we discuss the consequences of this dynamic dialogue between MSC and Th17 well described by their phenotypic and functional plasticity.
50
Shenoy, Santosh. "Synchronous gastric and colon cancers: Important to consider hereditary syndromes and chronic inflammatory disease associations." World Journal of Gastrointestinal Oncology 16, no. 3 (March 15, 2024): 571–76. http://dx.doi.org/10.4251/wjgo.v16.i3.571.
Повний текст джерелаАнотація:
In this editorial we comment on the manuscript, describing management and surveillance strategies in synchronous and metachronous, gastric and colon cancers. Synchronous or metachronous primary malignancies at different sites of the gastrointestinal tract pose a unique diagnostic and therapeutic challenge. Multidisciplinary services and strategies are required for the management of multiple site primary malignancies, to provide the best oncological outcomes. Although this study highlights the dual cancers in 76 sporadic cases, the authors excluded 55 patients due to combination of factors which includes; incomplete clinical data, genetic syndrome, gastric stump cancers. In addition, the authors did not elaborate if any patients presented with signet ring cell morphology, E-cadherin mutations or presence of inflammatory bowel disease. Genetic and mutational errors and epithelial field defects from chronic inflammatory diseases of the gastrointestinal tract are important when considering synchronous gastric and colonic cancers. We will briefly discuss these in this editorial.