Добірка наукової літератури з теми "Bone anabolism"
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Статті в журналах з теми "Bone anabolism"
Ruan, Feng, Qiang Zheng, and Jinfu Wang. "Mechanisms of bone anabolism regulated by statins." Bioscience Reports 32, no. 6 (September 14, 2012): 511–19. http://dx.doi.org/10.1042/bsr20110118.
Повний текст джерелаMartin, T. "Uncoupling anabolism from bone resorption." Bone 44 (June 2009): S203. http://dx.doi.org/10.1016/j.bone.2009.03.016.
Повний текст джерелаHariri, Hadla, Martin Pellicelli, and René St-Arnaud. "New PTH Signals Mediating Bone Anabolism." Current Molecular Biology Reports 3, no. 2 (April 22, 2017): 133–41. http://dx.doi.org/10.1007/s40610-017-0060-z.
Повний текст джерелаKlein, Gordon L. "The Role of Bone in Muscle Wasting." International Journal of Molecular Sciences 22, no. 1 (December 31, 2020): 392. http://dx.doi.org/10.3390/ijms22010392.
Повний текст джерелаTu, Xiaolin, Jesus Delgado-Calle, Keith W. Condon, Marta Maycas, Huajia Zhang, Nadia Carlesso, Makoto M. Taketo, David B. Burr, Lilian I. Plotkin та Teresita Bellido. "Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone". Proceedings of the National Academy of Sciences 112, № 5 (20 січня 2015): E478—E486. http://dx.doi.org/10.1073/pnas.1409857112.
Повний текст джерелаHorcajada, Marie-Noelle, and Elizabeth Offord. "Naturally Plant-Derived Compounds: Role in Bone Anabolism." Current Molecular Pharmacology 5, no. 2 (May 1, 2012): 205–18. http://dx.doi.org/10.2174/1874467211205020205.
Повний текст джерелаKramer, Ina, Hansjoerg Keller, Olivier Leupin, and Michaela Kneissel. "Does osteocytic SOST suppression mediate PTH bone anabolism?" Trends in Endocrinology & Metabolism 21, no. 4 (April 2010): 237–44. http://dx.doi.org/10.1016/j.tem.2009.12.002.
Повний текст джерелаTorre, Elisa. "Molecular signaling mechanisms behind polyphenol-induced bone anabolism." Phytochemistry Reviews 16, no. 6 (August 31, 2017): 1183–226. http://dx.doi.org/10.1007/s11101-017-9529-x.
Повний текст джерелаCheng, Su-Li, Jian-Su Shao, Jun Cai, Oscar L. Sierra, and Dwight A. Towler. "Msx2 Exerts Bone Anabolism via Canonical Wnt Signaling." Journal of Biological Chemistry 283, no. 29 (May 15, 2008): 20505–22. http://dx.doi.org/10.1074/jbc.m800851200.
Повний текст джерелаTowler, Dwight A. "Skeletal anabolism, PTH, and the bone-vascular axis." Journal of Bone and Mineral Research 26, no. 11 (October 21, 2011): 2579–82. http://dx.doi.org/10.1002/jbmr.523.
Повний текст джерелаДисертації з теми "Bone anabolism"
Fu, Xuekun. "The role of osteocyte Kindlin-2 in the anabolic actions of PTH in bone." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/741.
Повний текст джерелаSoon, Grace Ing. "The bone anabolic potential of dietary lysine and phytochemicals." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613967.
Повний текст джерела李振華. "Bone anabolic effect of flavonoids from Herba Epimedii in zebrafish and medaka." Thesis, University of Macau, 2010. http://umaclib3.umac.mo/record=b2454948.
Повний текст джерелаMiao, Dengshun. "Studies on the actions of bone anabolic drugs in vivo and in vitro." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300362.
Повний текст джерелаMatthies, Levi [Verfasser], and Eric [Akademischer Betreuer] Hesse. "The Role of Tgif1 in Bone Anabolic Signal Transduction / Levi Matthies ; Betreuer: Eric Hesse." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/116227526X/34.
Повний текст джерелаLiang, Chao. "Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA Interference-based bone anabolic strategy." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/325.
Повний текст джерелаMarcu, Jahan Phillip. "Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/233543.
Повний текст джерелаPh.D.
Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In this report, modeling studies identified residue K373, in the extracellular (EC)-3 loop, in charged interactions with D2.63. We investigated this possibility by performing reciprocal mutations and biochemical studies. D2.63176A, K373A, D2.63176A-K373A, and the reciprocal mutant with the interacting residues juxtaposed, D2.63176K-K373D were characterized using radioligand binding and guanosine 5'-3-O-(thio)triphosphate functional assays. None of the mutations resulted in a significant change in the binding affinity of CP55,940 or SR141716A. Computational results indicate that the D2.63176-K373 ionic interaction strongly influences the conformation(s) of the EC-3 loop, providing a structure-based rationale for the importance of the EC-3 loop to signal transduction in CB1. Specifically, the putative ionic interaction results in the EC-3 loop pulling over the top (extracellular side) of the receptor; this EC-3 loop conformation may serve protective and mechanistic roles. These results suggest that the ionic interaction between D2.63176 and K373 is crucial for CB1 signal transduction. This work may help to aide drug design efforts for the effective treatment of different diseases. The cannabinoid receptors of osteoblasts may represent a target for the treatment of bone disorders such as osteoporosis. Our research demonstrates that cannabinoids can affect important signaling molecules in osteoblasts. In MC3T3-E1 osteoblastic cells, the CB1 antagonist, AM251, has been reported to induce increases in Runx2 mRNA, mineralized bone nodule formation, and activation of signaling molecules such as ERK and AKT (Wu et al., 2011). Studies from our lab characterizing mice in which both CB1 and CB2 receptors were inactivated by homologous recombination have demonstrated increased bone mass coupled with enhanced osteoblast differentiation of bone marrow stromal cells in culture (manuscript in preparation). We explored the effect of antagonizing CB1 and CB2 cannabinoid receptors in osteoblastic cells to gain insights into molecular pathways that may help to explain the effects of the endocannabinoid system (ECS) in bone development. Our data was generated by running time course experiments with MC3T3-E1 cells under the influence of SR141716A, SR144528 or both in combination. The cells were harvested with a lysis buffer at specific time points and analyzed by western blot analysis. Quantification of protein activation was calculated using LiCor imaging equipment and software. Within 15 minutes, treatment with the CB1 receptor antagonist SR141716A resulted in several fold increases in pERK, pSMAD158, and pAKT. SR144528, a CB2 receptor antagonist, caused increases in pERK and pSMAD158, but not pAKT. When both antagonists were applied together, pERK and pSMAD158 levels increased, while pAKT signaling was diminished compared to SR141716A alone. The finding that cannabinoid receptor antagonists alter the activity of the SMAD158 complex is a novel finding, which suggests that cannabinoids can influence bone morphogenic signaling pathways, and therefore play a significant role in osteoblast differentiation and function.
Temple University--Theses
Jay, Freya [Verfasser], and Marlon [Akademischer Betreuer] Schneider. "Role of amphiregulin in mediating the bone anabolic actions of parathyroid hormone / Freya Jay ; Betreuer: Marlon Schneider." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1117473953/34.
Повний текст джерелаAschenberg, Sophie [Verfasser], and Georg [Akademischer Betreuer] Schett. "Catabolic and anabolic periarticular bone changes in patients with rheumatoid arthritis: a computed tomography study on the role of age, disease duration and bone markers / Sophie Aschenberg. Gutachter: Georg Schett." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1075741653/34.
Повний текст джерелаGuimarães, Ana Paula Franttini Garcia Moreno. "Decanoato de nandrolona, qualidade óssea e calo ósseo em fratura do fêmur de rato." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17142/tde-29032018-100618/.
Повний текст джерелаThere has been a great interest in investigating systemic substances that can positively act on the musculoskeletal system to improve the bone quality thus avoiding osteoporotic fractures. The anabolic androgenic steroids have an important influence on general metabolism and can increase the bone resistance and bone mass. On muscle, it improves sarcopenic conditions. However, there is no consistent investigation of a possible action of these substances on bone callus. Thus, the aim of this study was to evaluate the effect of decanoate of nandrolone on fracture healing and bone quality of young adult male Wistar rats. One hundred animals were divided into 04 groups and 02 subgroups (14 and 28 days). A control group consisted of animals without any intervention (n=17). In the second group, a femoral shaft fracture was performed (n=26). In the third group, the animals received only decanoate of nandronole (n=23). In the fourth group, a fracture in the femoral shaft was performed and associated with administration of the same dose of decanoate of nandrolone (n=26). The fracture created in the femur was obtained by closed method and achieved with the aid of a blunt blade guillotine. After that, the fracture was fixed with a 1.0 mm thick Kirschner wire that was inserted into the medullary canal, and the limb was X-rayed in profile. Ten mg/kg of body mass of decanoate of nandrolone was administered intramuscularly, 02 times a week for 14 or 28 days, depending on the subgroup. After euthanasia, the right femurs were dissected and had the length measured. Bone mineral density and bone mineral content were determined by the dual-energy x-ray absorptiometry method (DXA). The mechanical properties maximum force and stiffness were determined by the twopoint bending test. The bone callus was evaluated microscopically in sections stained with hematoxylin and eosin and examined under ordinary light microscope to calculate the volume of bone callus by the morphometric technique. Other sections were stained in picrosirius red and examined under polarized light for quantification of type I collagen. The statistical significance was set at 5%. There was no significant difference between the animals treated and not treated with nandrolone decanoate for bone mass density, bone mineral content, mechanical resistance and type I collagen, both for the intact bone and for the bone callus. However, the body mass was higher in the groups that received nandrolone decanoate, although without statistical significance. The femur length was greater in the 28th day in the group treated with nandrolone decanoate. Callus mass also had significant increase at 28 days for animals that received nandrolone decanoate. Based on the results and under the experimental conditions and methods of evaluation, the decanoate of nandrolone did not cause significant benefit or harmfull effects both on callus and on bone qualities.
Книги з теми "Bone anabolism"
Whitfield, James F. Growing bone. 2nd ed. Austin, Tex: Landes Bioscience, 2007.
Знайти повний текст джерелаWhitfield, James F. Growing bone. 2nd ed. Austin, Tex: Landes Bioscience, 2007.
Знайти повний текст джерелаWhitfield, James F. Growing bone. 2nd ed. Austin, Tex: Landes Bioscience, 2007.
Знайти повний текст джерелаC, Farach-Carson Mary, and United States. National Aeronautics and Space Administration., eds. Round 1 progress report: Anabolic vitamin D analogs as countermeasures to bone loss. [Washington, DC: National Aeronautics and Space Administration, 1997.
Знайти повний текст джерелаPrinciples Of Bone Regeneration. Springer, 2012.
Знайти повний текст джерелаWhitfield, James F. Growing Bone. Landes Bioscience, 2005.
Знайти повний текст джерелаWhitfield, James F. Growing Bone. Taylor & Francis Group, 2007.
Знайти повний текст джерелаWhitfield, James F. Growing Bone. Taylor & Francis Group, 2007.
Знайти повний текст джерелаBoonstra, Johannes. Gi Phase Progression. Eurekah.Com Inc, 2004.
Знайти повний текст джерелаЧастини книг з теми "Bone anabolism"
Rosen, Clifford J. "Bone Anabolic Agents." In Atlas of Osteoporosis, 195–207. London: Current Medicine Group, 2003. http://dx.doi.org/10.1007/978-1-4757-4561-0_17.
Повний текст джерелаBab, Itai A. "Anabolic Agents in Bone Repair." In Principles of Bone Regeneration, 51–58. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-2059-0_4.
Повний текст джерелаGeusens, P., D. Vanderschueren, and S. Boonen. "Androgens and Anabolic Steroids." In Management of Fractures in Severely Osteoporotic Bone, 462–73. London: Springer London, 2000. http://dx.doi.org/10.1007/978-1-4471-3825-9_33.
Повний текст джерелаChambers, Tim J., Jade Wei Mun Chow, Jennifer M. Lean, and Jonathan H. Tobias. "The Anabolic Action of Estrogen on Rat Bone." In Sex Steroids and Bone, 19–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-03043-1_2.
Повний текст джерелаOlgun, Z. Deniz, Arianna Gianakos, Jonathan E. Jo, and Joseph M. Lane. "Bisphosphonates, Denosumab, and Anabolic Agents in the Treatment of Metastatic Bone Disease." In Metastatic Bone Disease, 121–29. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-5662-9_12.
Повний текст джерелаRamchand, Sabashini K., and Ego Seeman. "Reduced Bone Modeling and Unbalanced Bone Remodeling: Targets for Antiresorptive and Anabolic Therapy." In Bone Regulators and Osteoporosis Therapy, 423–50. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/164_2020_354.
Повний текст джерелаBilezikian, John P., and Natalie E. Cusano. "Combination Anabolic and Antiresorptive Therapy for Osteoporosis." In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 444–47. Ames, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118453926.ch53.
Повний текст джерелаKrstenansky, J. L., T. L. Ho, Z. Avnur, D. Leaffer, J. P. Caulfield, and B. H. Vickery. "RS-66271: Molecular design and in vivo bone anabolic activity." In Peptides 1994, 133–34. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_50.
Повний текст джерелаRemer, Thomas, and Lars Libuda. "Bone-Anabolic Impact of Dietary High Protein Intake Compared with the Effects of Low Potential Renal Acid Load, Endogenous Steroid Hormones, and Muscularity in Children." In Nutritional Influences on Bone Health, 187–96. London: Springer London, 2010. http://dx.doi.org/10.1007/978-1-84882-978-7_27.
Повний текст джерелаSoper, David Lindsey, Yili Wang, Biswanath De, Mitchell Anthony deLong, Michelle Jeanine Dirr, Michele Elaine Soehner, Mark Walden Lundy, Glen Edward Mieling, and John August Wos. "The Design and Synthesis of Selective Prostaglandin Analogs As Bone Anabolic Agents for the Potential Treatment of Osteoporosis." In Advances in Experimental Medicine and Biology, 303–7. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0193-0_46.
Повний текст джерелаТези доповідей конференцій з теми "Bone anabolism"
Askew, Michael J., Gary B. Schneider, Kristina J. Grecco, Jason Hsu, Emily Mugler, and Donald A. Noe. "Effect of Pharmaceutical Bone Growth Stimulation With Novel Anabolic Peptides: Biomechanical and Bone Density Measurements in a Rat Model." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43044.
Повний текст джерелаUddin, Sardar M. Zia, and Yi-Xian Qin. "Anabolic Effects of Ultrasound as Countermeasures of Simulated Microgravity in In-Vitro and In-Vivo Functional Disuse Models." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53796.
Повний текст джерелаCoughlin, Thomas R., Laoise M. McNamara, Peter E. McHugh, and Glen L. Niebur. "Shear Stress Within Trabecular Bone Marrow due to Low Magnitude High Frequency Vibration." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53803.
Повний текст джерелаAltman, Allison R., Beom Kang Huh, Abhishek Chandra, Wei-Ju Tseng, Ling Qin, and X. Sherry Liu. "3D In Vivo Bone Dynamic Imaging of PTH’s Anabolic Action." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14671.
Повний текст джерелаHart, Stephen A., and Marcelo J. Dapino. "Accelerated Bone Growth Remotely Induced by Magnetic Fields and Smart Materials." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175966.
Повний текст джерелаVallapuri, Teja, Colin Crean, John Chirgwin, G. David Roodman, and Attaya Suvannasankha. "Abstract 693: Effects of a bone-anabolic agent on metastatic bone cancer growth." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-693.
Повний текст джерелаYanoso, Laura, Justin Jacobson, Tulin Dadali, David Reynolds, and Hani Awad. "Evaluation of Polylactic Acid/Beta-Tricalcium Phosphate Scaffolds as Segmental Bone Graft Substitutes." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192978.
Повний текст джерелаFields, Aaron J., Susan M. Millard, Jeannie F. Bailey, Dylan O’Carroll, Jeffrey C. Lotz, and Robert A. Nissenson. "Bone Biomechanical Behavior in Adult Mice is Regulated by Osteoblast Gi Signaling in a Sex- and Site-Specific Manner." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53773.
Повний текст джерелаQin, Yi-Xian, Tamara Kaplan, and Hoyan Lam. "Anabolic Fluid Flow as Dependent on It Dose and Frequency in Bone Formation and Inhibition of Bone Loss." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61388.
Повний текст джерелаQin, Yi-Xian, Hoyan Lam, and Murtaza Malbari. "The Effects of Loading Rate and Duration on Mitigation of Osteopenia by Dynamic Muscle Stimulation." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206685.
Повний текст джерелаЗвіти організацій з теми "Bone anabolism"
Xiao, Guozhi. ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone. Fort Belvoir, VA: Defense Technical Information Center, July 2008. http://dx.doi.org/10.21236/ada499647.
Повний текст джерелаXiao, Guozhi. ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone. Fort Belvoir, VA: Defense Technical Information Center, July 2010. http://dx.doi.org/10.21236/ada541206.
Повний текст джерелаXiao, Guozhi. ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone. Fort Belvoir, VA: Defense Technical Information Center, July 2009. http://dx.doi.org/10.21236/ada508520.
Повний текст джерелаXiao, Guozhi. ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone. Fort Belvoir, VA: Defense Technical Information Center, July 2011. http://dx.doi.org/10.21236/ada550617.
Повний текст джерелаXiao, Guozhi. ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone. Fort Belvoir, VA: Defense Technical Information Center, January 2012. http://dx.doi.org/10.21236/ada558869.
Повний текст джерелаQin, Weiping. Anabolic Steroids as a Novel Therapeutic Strategy for the Prevention of Bone Loss after Spinal Cord Injury: Animal Model and Molecular Mechanism. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada591955.
Повний текст джерела