Дисертації з теми "Blood cell imaging"
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Eilken, Hanna. "Blood Generation from Hemogenic Endothelium Proven by Continuous Single Cell Imaging." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-98438.
Повний текст джерелаLim, Brian. "Modeling ultrasound imaging of red blood cell aggregation in shear flow." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0006/NQ41213.pdf.
Повний текст джерелаNunez, Munoz Juan Antonio. "Utilising high resolution imaging to interrogate blood vessel and bone cell interactions." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/422899/.
Повний текст джерелаMiller, Brandon Lee. "Quantitative, Multiparameter Analysis of Fluorescently Stained, Negatively Enriched, Peripheral Blood from Cancer Patients." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1386005404.
Повний текст джерелаChen, Miao. "Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96188.
Повний текст джерелаPHD
PILLAI, Vinoshene. "Intravital two photon clcium imaging of glioblastoma mouse models." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/109211.
Повний текст джерелаChinchilla, Lenin. "Quantitative ultrasound techniques to characterize soft tissue anisotropy." Thesis, Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0154.
Повний текст джерелаQuantitative ultrasound techniques based on the parameterization of the backscatter coefficient (BSC) generally assume that the tissue under investigation is homogeneous and isotropic. However, some tissues such as flowing red blood cell (RBC) aggregates, myocardium or bicep muscles exhibit angle-dependent acoustic properties (BSC and/or attenuation coefficient). The objective of this thesis was to incorporate anisotropy in tissue backscatter analysis. First, an ultrasonic backscattering model is proposed and evaluated numerically to characterize the anisotropic structures of RBC aggregates. Then, an experimental procedure was evaluated to measure BSC anisotropy in tissue-mimicking phantoms. More specifically, a performance comparison is carried out between a capacitive micromachined ultrasonic transducer probe and a commercial piezoelectric probe to measure backscatter anisotropy by using the focused beam steering imaging strategy
Nazerzadeh-Yazdi, Arvin. "Lensless imaging of red blood cells using coherent soft x-ray scattering." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/32151.
Повний текст джерелаScience, Faculty of
Physics and Astronomy, Department of
Graduate
Dhaya, Ibtihel. "Study of the blood-brain interface and glial cells during sepsis-associated encephalopathy : from imaging to histology." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0966/document.
Повний текст джерелаSepsis-associated encephalopathy (SAE) refers to central nervous system dysfunction during the systemic inflammatory response to infection. In septic patients with encephalopathy MRI has indicated both gray and white matter abnormalities that were associated with worse cognitive outcome including delirium. To improve our understanding of sepsis-associated hemodynamic, metabolic, and structural changes, different MRI sequences were performed in rats that either underwent an i.p injection of saline or bacterial lipopolysaccharide (LPS) 2.5h earlier or cecal ligation and puncture (CLP) 24h earlier. After ip LPS, phase contrast MRI was performed to study anterior and middle cerebral arteries flow and Arterial Spin Labeling (ASL) to study perfusion of white and grey matter brain structures. Diffusion Weighted Imaging (DWI) sequences was used to assess structural changes. After CLP surgery, ASL was used to study microcirculation changes. T2-Weighted Imaging, Diffusion Tensor Imaging (DTI) and tract-based spatial statistics (TBSS) were performed to characterize structural events in different brain structures. After imaging, animals were sacrificed and their brains processed for histology to detect the vasoactive prostaglandin-synthesizing enzyme cyclooxygenase-2 (COX-2) and the astrocytic aquaporin-4 water channel (AQP4) the expression of which can be upregulated during inflammation, to assess the presence of perivascular immunoglobulins (Ig) indicating blood-brain barrier (BBB) leakage and to study glia cell morphology as both microglia and astrocytes are known to change their morphology in inflammatory conditions. Magnetic resonance rat brain imaging indicated no hemodynamic changes in the grey matter after ip LPS administration while an increased CBF was shown in corpus callosum white matter as indicated by ASL. DTI indicated increased water diffusion parallel to fibers of the corpus callosum white matter. These changes were accompanied by BBB breakdown in the white matter and adjacent cortical and striatal grey matter as indicated by the perivascular presence of IgG, but no major changes in vascular COX-2 or white matter glia cell morphology. CLP induced sepsis-associated CNS dysfunction resulted in higher T2-weighted contrast intensities in the cortex, striatum and base of the brain, decreased blood perfusion distribution to the cortex and increased water diffusion in the corpus callosum and ventral striatum compared to sham surgery. These changes were associated in the white matter with modifications in glia cells morphology and in the grey matter with lower expression of constitutive COX-2 expression and AQP4 in the cerebral cortex. The comparison between CLP that underwent or not MRI under isoflurane anesthesia indicated reduced inflammatory response as indicated by COX-2 expression, reduced glia activation and reduced BBB damage in CLP that underwent MRI under isoflurane anesthesia. Collectively, our results suggest that hemodynamic changes may occur in the absence of altered flow in forebrain irrigating arteries. Then, altered white matter structure is an early step in SAE pathogenesis that may result either from BBB breakdown or glial cells activation. This study underlies the deleterious effects of a single exposure to isoflurane anesthesia that may be mitigated by a second exposure in sham-operated rats and the effects of CLP-induced systemic inflammation on glial cells that can be attenuated by imaging under isoflurane anesthesia
Mauricio, Claudio Roberto Marquetto. "Contador de células vermelhas baseado em imagens para múltiplas espécies de animais silvestres e domésticos." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2314.
Повний текст джерелаA RBC count plays an important role in the diagnostic of wild and domestic animals. Despite the many technologies available in different automated hematology analyzers, when it comes to blood of wild animals it is still difficult to find an easy and affordable solution for multiple species. This study aims to develop an automatic red blood cell counter. Blood samples (1 ocelot - Leopardus pardalis, 1 monkey - Cebus apella, 1 coati - Nasua nasua, 62 dogs - Canis familiaris and 5 horses - Equus caballus) were analyzed using three methods: 1-manual count, 2automatic count by image and 3-semi-automatic count by image; blood from dogs and horses were also analyzed by a fourth method: 4-automatic count by impedance. The counts of methods 2 and 3 were produced by the proposed red blood cell counter. Results were compared using Pearson’s correlation and plots with different methods as the criterion standard. RBC counts of methods 1, 2 and 3 correlated very well with those on the method 4 (r ≥ 0.94). RBC counts produced by method 2 were highly correlated with method 3 (r = 0.998). The results indicate that the proposed method can be used as an automatic or semi-automatic counting method in clinics that are currently using the manual method for RBC assessment.
Anderl, Ines. "Activation of the Cellular Immune Response in Drosophila melanogaster Larvae." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106981.
Повний текст джерелаLedford, Benjamin. "Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/93593.
Повний текст джерелаPHD
Henninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.
Повний текст джерелаBertoni, Lélia. "Évaluation du potentiel thérapeutique des cellules souches mésenchymateuses dans un modèle d'arthropathie expérimentale induite chez le cheval Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1 Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization Evaluation of allogeneic bone-marrow-derived and umbilical cord blood-derived mesenchymal stem cells to prevent the development of osteoarthritis in an equine model Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC417.
Повний текст джерелаOsteoarthritis is a common cause of pain and economic loss in both humans and horses. There is currently no curative treatment for osteoarthritis, because of the lack of spontaneous regenerative capacity of the articular cartilage. Mesenchymal stem cells (MSC) based regenerative medicine comes across as a promising strategy given their pro-regenerative and anti-inflammatory potential. The first objective of this study was to evaluate the safety of umbilical cord blood (UCB) and bone marrow (BM) derived MSC in healthy joints. The blind controlled study conducted on 12 experimental horses showed that the injection of BM-MSC caused significantly more signs of inflammatory reaction than the injection of UCB-MSC, and that the injection of MSC, regardless of their origin, caused a discrete to moderate inflammatory reaction, greater than that of the placebo, with great individual variability in sensitivity to the same cell line. The second objective was to evaluate the efficacy of BM-MSC and UCB-MSC in a model of induced osteoarthritis. The blind controlled study conducted on 8 experimental horses showed a significant reduction in the progression of osteoarthritis associated signs with imaging techniques after injection of allogeneic BM-MSC compared to placebo. These promising results, to be considered in light of the limitations of the studies, indicate a beneficial effect of allogeneic BM-MSC in the management of osteoarthritis in horses. They underline the need for further research to confirm these results, and to optimize the effects of MSC through their combination with a vector or through an acellular approach with administration of the nanovesicles they secrete that ared considered to be responsible for their therapeutic effects
Eilken, Hanna [Verfasser]. "Blood generation from hemogenic endothelium proven by continuous single cell imaging / submitted by Hanna Eilken." 2008. http://d-nb.info/993862152/34.
Повний текст джерелаGangadhar, Eluru. "Novel Micro fluidic Techniques for Point-of-Care Diagnostics." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/4469.
Повний текст джерелаKataria, Kartik. "Transport of Intensity Equation based Quantitative Phase Imaging of Red Blood Cells." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5799.
Повний текст джерела"A Simple Microfluidic Device for Automated, High-Throughput Measurement of Morphology of Stored Red Blood Cells." Tulane University, 2013.
Знайти повний текст джерелаacase@tulane.edu
Traoré-Dubuis, Ali. "De la modélisation à la quantification par ultrasons de l'agrégation érythrocytaire." Thèse, 2013. http://hdl.handle.net/1866/10298.
Повний текст джерелаMany studies have reported that an enhanced level of red blood cell aggregation is associated with the presence of hemorheological disorders. Pathological aggregation has been characterized by quantitative ultrasound based on the backscattering coefficient. In order to describe the interaction between the incident ultrasound and the interrogated biological tissues, mathematical models are used. Mathematical modeling is known to be the optimal way to describe the interaction occurring between ultrasound and tissues at the cellular level. The structure factor model (SFM), considered as the exact scattering model has been developed to predict the backscattering coefficient from blood. However, the numerical SFM cannot be applied in real time for practical measurements and does not provide aggregate size to assess the level of aggregation. Therefore, we come up with a new model based on the effective medium theory in order to tackle this difficulty. The effective medium theory combined with the structure factor model (EMTSFM) can be applied in real time and contrary to the SFM provides two indices of the aggregate state in vivo: aggregate size and compactness. Based on a 3D simulation study, the backscattering coefficients (BSCs) predicted by the effective medium theory combined with the Structure Factor Model (EMTSFM) are compared to the BSCs computed with SFM. Our aim here is to assess the accuracy of the EMTSFM against the SFM by comparing their BSC in the framework of a forward problem, i.e., the calculation of the BSC from the known acoustic and structure aggregate parameters. This was done in order to validate the proposed model. To simulate aggregates, RBCs are stacked following a hexagonal close packing scheme. The influences of the aggregate radius and compactness on the BSC are studied as well. The results showed good agreement between the SFM and the EMTSFM based on our simulated microstructure of RBC aggregates. Our work provides thus the theoretical background to assess locally the aggregation level for diagnosis purposes.
Le travail a été réalisé en collaboration avec le laboratoire de mécanique acoustique de Marseille, France. Les simulations ont été menées avec les langages Matlab et C. Ce projet s'inscrit dans le champ de recherche dénommé caractérisation tissulaire par ultrasons.
Sebali, Jennifer. "Role of MCAM+ Regulatory T cells in multiple sclerosis." Thesis, 2020. http://hdl.handle.net/1866/24533.
Повний текст джерелаIn multiple sclerosis (MS), autoreactive T cells upregulate cellular adhesion molecules (CAMs) to cross the blood brain barrier (BBB), enter the central nervous system (CNS) and mediate damage to myelin. Regulatory T cells (Treg) are one of the key components of immune tolerance, protecting against autoimmune reactions. However, Treg's entry and function in the CNS remains largely unknown. Our lab has demonstrated the contribution of several CAMs, including melanoma cell adhesion molecule (MCAM), in the migration of pathogenic lymphocytes across the BBB. The goal of this study is to determine whether Treg migrate into the inflamed CNS using MCAM and exert anti-inflammatory functions, possibly dampening CNS inflammation. The expression of MCAM and Treg functional markers and chemokine receptors (CTLA-4, CCR6, CCR5,), as well as cytokine secretion (IL-10, GrzmB, TGF-ß, IFN-γ, TNF α, GM-CSF, IL-17a), were studied on MS patients and healthy individuals (HC) Treg from the peripheral blood, cerebrospinal fluid (CSF), and in vitro culture, by flow cytometry, in corroboration with qPCR and ELISA. Moreover, the presence of MCAM+ Treg in the CNS was assessed by immunohistofluorescence (CD4, CD25, Foxp3, MCAM, nuclei) on experimental autoimmune encephalomyelitis (EAE) affected mice. Our data showed an increase in the expression of MCAM on Treg during relapse-remitting MS patients (RRMS) compared to HC. We observed a trend for a higher frequency of MCAM+ Treg cells in the CSF versus the peripheral blood of MS patients, suggesting that MCAM might play an important role in the migration of Treg. These MCAM+ Treg seem to have a more functional and anti-inflammatory phenotype than their MCAM- counterparts. Moreover, we found higher levels of MCAM+ Treg in periods of EAE remission, underlining their involvement during this disease phase. Overall, our data depicts MCAM as an essential CAM for Treg homing to the CNS.
Banoth, Earu. "Absorption Flow-Cytometry for Point-of-Care Diagnostics." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/3620.
Повний текст джерелаBanoth, Earu. "Absorption Flow-Cytometry for Point-of-Care Diagnostics." Thesis, 2017. http://etd.iisc.ernet.in/2005/3620.
Повний текст джерела